Phytochemical Polysulfides, the Natural and Potential Chemo- Therapeutic Agent for colon Cancer with No Side Effects

By Kyle J. Norton

Phytochemical Polysulfides may be considered a functional supplement in reducing the risk and treatment of colon cancer.

Colon cancer is a very slowly growing medical condition characterized by irregular cell growth in the colonic tissue.

At the advanced stage, cancerous cells can travel a distance away from the colon to infect other healthy tissue and organ through lymph and blood.

The colon is a part of the digestive system involved the absorption of water from the small bowel contents and broken down of certain materials of the feces into substances of which some of them to be reabsorbed and reused by the body.

According to the statistics,  in Canada, every year approximately over 17,000 new cases of colorectal cancer are diagnosed causing over 6500 death

Colorectal cancer ranks third overall in the number of both new cancer cases and cancer deaths in Canada.

The causes of colon cancer are unknown. however, people who are obese, follow the Western diet and long-term exposure to ionizing radiation due to occupation are some of the most prevalent risk factors that cause colon cancer.

The “Western” diet, characterized by high intakes of saturated fat and trans fat, red and processed meats, sweets, refined grains, and desserts increased the risk and recurrent risk of colon cancer, according to the study published on the Aug. 15 issue of the Journal of the American Medical Association.

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Dr. the lead scientist in the comparison of diet pattern said, " Compared to the Western-Southern pattern, the fruit-vegetable and metropolitan patterns were associated with more healthful dietary behaviors (e.g., higher vegetable intake and lower red meat consumption), and demographic/lifestyle characteristics typically correlated with low colon cancer risk, for example, lower BMI, higher education, and higher NSAID use".

Therefore, by changing diet pattern from the Western diet to traditional diet with more fruits and vegetable, reducing weight and actively engaging in a healthy lifestyle, risk of colon cancer are decreased substantially.

If you have a sudden change of bowel habits such as diarrhea or constipation that last more than 3 to 4 weeks, persistent blood in the stool and abdominal cramps, gas or pain, accompanied fatigue with no reason and unexplained weight loss, please check with your doctor right the way to rule out the possibility of colon cancer.

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group ofOrganosulfides found abundantly in an oxidized product, including beer, wine, whiskey, garlic oil, etc.

In the finding, the new anti-colon cancer drug with the same effect of diallyl polysulfides are well known as anticancer drugs with no side effects, researchers at the University of the Saarland conducted an experiment to examine the effect of the combined coumarins with polysulfides in the form of di-coumarin polysulfides in HCT116 colorectal cancer cell line.

Application of combination reduced cell viability of cancer cells in a time and concentration-dependent manner.

The combined coumarins with polysulfides exerted apoptosis through the G(2)/M phase of the cell cycle.

The apoptosis activity was attributed to the effect of the combined coumarins with polysulfides in the activation of the proteins that program cell death.

In the comparison of these new coumarin compounds with the well-known diallyl polysulfides, researchers found that the coumarin disulfides are more active than the corresponding diallyl disulfides.

Dr. Saidu NE, the lead author in the final report said, "coumarin polysulfides also down-regulated the level of Cell Division Cycle 25C,(cdc25C), which also contributed to the arrest in the G(2)-phase of the cell cycle".

Futhermore, in the evaluation of the garlic-derived organosulfur compounds such as diallyl sulfide, a member of polysulfides, researchers revealed that the compound exerts a significant influence on cell viability, cell cycle arrest and induction of apoptosis in HCT116 human colon cancer cells.

Diallyl trisulfide is even more efficiently diallyl tetrasulfide treatment of HCT116 cells that lead to a reduced cell viability, cell cycle arrest, and apoptosis.

Additional analysis suggested that the efficacy of the compound was attributed to the function in inhibition of the redox state of the cell, and its anti-oxidants that prevent sulfide-induced apoptosis.

The growth arrest and induction of apoptosis are associated with a considerable reduction of the level of cdc25C similar to those of the previous study.

Taken together, the bioactive polysulfides may be considered a functional phytochemical for the prevention of colon cancer and combined with primary therapy for the treatment of colon cancer.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells by Saidu NE1, Valente S, Bana E, Kirsch G, Bagrel D, Montenarh M.(PubMed)
(2) Diallylpolysulfides induce growth arrest and apoptosis by Busch C1, Jacob C, Anwar A, Burkholz T, Aicha Ba L, Cerella C, Diederich M, Brandt W, Wessjohann L, Montenarh M.(PubMed)
(3) Dietary Patterns and Colon Cancer Risk in Whites and African Americans in the North Carolina Colon Cancer Study by Jessie A. Satia, Marilyn Tseng, Joseph A. Galanko, Christopher Martin, and Robert S. Sandler. (PubMed)

Phytochemical Tartaric Acid Improves the Digestive Absorption and Feces Secretion

By Kyle J. Norton

Tartaric acid, an organic phytochemical may process a significant effect in improving the digestive function in the absorption of nutrients and fluids from foods intake, some scientists found.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.

In human, the digestive system consists of a set of accessory organs of digestion and the gastrointestinal tract, involving in the breakdown of food into smaller and smaller components, until they can be absorbed and assimilated into the body.

There is no single cause of the digestive disorder. the disorder can be induced by multiple factors including bacterial infection, viral infection, inflammation, lactase deficiency, intake of some difficulty digesting certain foods.

In severe cases, the digestive disorder can be caused by poor circulation to the intestines or other organs and complication of other medical conditions such as muscle dysfunction, gallstones, stress, and side effects of certain medications including the anti-inflammatory drugs.

Other common diseases that cause digestive disorder also include irritable bowel syndrome and disease, heartburn.

Most common acute symptoms of digestive disorders are bloating, diarrhea, gas, stomach pain, and stomach cramps.

Lifestyle has been found to associate with the onset of digestive disorders. Dr. Hall EH, the lead scientist in the digestive disorders team in the investigation of the effects of environmental and lifestyle on disorders of the large and small intestine, wrote, "External factors including obesity, lack of physical exercise, and tobacco consumption also impact diseases of the luminal gastrointestinal (GI) tract" and : new treatment options for celiac disease reflect the complex interaction of diet, genetic factors, and the host immune response, the implications for treatment of many conditions of the large and small intestine that arise from environmental and lifestyle are as basic as ensuring adequate nutrition, regular exercise, and cessation of tobacco use".

This statement suggested, by following a healthy diet and lifestyle with moderate exercise is one of the best methods that reduce substantially the risk of digestive disorders.

Tartaric acid is a phytochemical of the organic acid found abundantly in nuts, apricots, apples, sunflower, avocado, grapes, etc.

In the study to examine the effects of D-tartaric acid (TA) on intestinal drug absorption under both in situ and in vitro experimental conditions, researchers found that
* TA improved paracellular drug transport by changes the integrity of the epithelial tight junctions in rat colon at low pH conditions.

* Application of TA (20 mM) increased the absorption of Rho123, a chemical compound and a dye in both ileum and colon but not in the jejunum.

* TA (20 mM) also increased the absorption of daunorubicin in the ileum, but TA (20 mM) did not change the expression level of P-glycoprotein (P-gp) which processes a function in pumping foreign substances out of cells.

* TA (20 mM) significantly inhibited excretion of i.v.-administered Rho123 and daunorubicin into the ileal lumen.

These results suggested that TA increases the intestinal absorption of P-gp substrates Rho123 and daunorubicin, a chemotherapy medication used to treat cancer, by modulating the P-gp function without changing the expression level of P-gp in the rat intestine.

Futhermore, in the evaluation of the new starch preparations produced by thermolysis of potato starch in the presence of inorganic (hydrochloric) and organic (citric and tartaric) acids under controlled conditions to examine whether the new starch effect in intestinal absorption.

Dextrin D3, obtained by heating starch acidified with hydrochloric and tartaric acids exerted a strong effect in breaking down foods into simpler chemical compounds. and absorbed by the digestive tract.

The presence of high concentration of the tartaric acid at had a significantly stronger influence on chemical breakdown of a compound due to reaction with water compared to on citric acid.

The results confirmed the possibility of applying dextrins, prepared under specific conditions, as soluble dietary fiber in the promotion of colon feces movement.

Taken altogether, the Tartaric acid may be considered a function supplement in improving the digestive system in breaking down foods for absorption of nutrients and fluids for the body need and

promoting the colon feces secretion.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid by Iida A, Tomita M, Idota Y, Takizawa Y, Hayashi M.(PubMed)
(2) New starch preparations resistant to enzymatic digestion by Jochym K, Kapusniak J, Barczynska R, Sliżewska K.(PubMed)
(3) Environmental and lifestyle influences on disorders of the large and small intestine: implications for treatment by Hall EH1, Crowe SE.(PubMed)

Phytochemical Allyl isothiocyanate, the Potential Anti Bladder Cancer Functional Remedy

By Kyle J. Norton, Master of Nutrition

Allyl isothiocyanate, a phytochemical found abundantly in the horseradish may have a strong effect in reducing risk and treatment of bladder cancer, some studies suggested.

Human bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is a medical condition characterized by irregular cell growth in the bladder tissue due to the alternation of DNA.

Most cases of primary bladder cancer start on the cell in the surface of the inner lining. However, after growing large enough, the cancerous call can spread to other regions in the body through the circulation of fluids and blood.

According to the statistic. 90% of bladder cancer were diagnosed in people who are older than 55. and the average age people are diagnosed with bladder cancer is 73.

Every year, the disease causes over 17,000 deaths and bladder cancer is the eighth most common cause of cancer death in men.

Out of the many causes of bladder cancer, researchers found that lifelong smoking, aging, and chronic bladder inflammation are some of the most common prevalent risk factors of bladder cancer cases found in the Western world.

Dr. Neal D Freedman, the lead author in the study "Association between smoking and risk of bladder cancer among men and women" clearly stated, "the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".

" Over the last 30 years, incidence rates have remained stable in the United States (men: 123.8/100,000 person-years to 142.2/100,000 person-years; women: 32.5/100,000 person-years to 33.2/100,000 person-years)".

The study suggested if you quit smoking today, re\gardless of now many years that you have been smoking, your risk bladder cancer is reduced compared to those do not.

In chronic bladder inflammation patients, Dr. Michaud DS, in the review the relation among patients in Egypt with a chronic bladder infection and inflammation in the risk bladder cancer suggested inflammation is likely to have an important role in bladder carcinogenesis in developed countries probably associated with the genetic susceptibility to inflammatory pathways that cause persistent inflammation in damaging the cells in the bladder.

In some cases, the persistent inflammation can lead to the alternation of the cells DNA.

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

In the study to reaffirm the effect of Allyl isothiocyanate (AITC)in the inhibition of the urinary bladder cancer growth and progression, researchers at the Department of Chemoprevention.launched
an investigation to examine the effect of the phytochemical used combination with the conventional medicine Celecoxib, a selective Cox-2 inhibitor against bladder cancer in the animal model.

Injection of the combination of AITC and celecoxib at low dose levels (AITC at 1 mg/kg and celecoxib at 10 mg/kg) in a syngeneic rat model of orthotopic bladder cancer showed to increased or perhaps synergistic inhibition of bladder cancer growth and muscle invasion, compared with each agent used alone.

Furthermore, the combination regime was also more effective than every single agent in inhibiting microvessel formation and stimulating microvessel maturation in the promotion of the growth of cancer in the tumor tissues.

The results of the efficacy of the combination was associated with the inhibition of the levels of prostaglandin E2 which not only plays an important role in the promotion of tumor growth but also is a  key downstream signaling molecule of Cox-2, caspase activation in the induction of cancer cell proliferation in solid tumors and downregulation of vascular endothelial growth factor in facilitating the growth of new blood vessels to the tumor tissues.

Dr. the lead author said, at the final report said, "ITC and celecoxib complement each other for inhibition of bladder cancer and provide a novel combination approach for potential use for prevention or treatment of human bladder cancer".

Additionally, in the human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells injection of NAC-AITC at 15 μM results in significant inhibition of cell growth and proliferation, together with cell cycle arrest and apoptosis.

Where AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl) cysteine, more commonly known as the N-acetylcysteine conjugate (NAC-AITC).

In an orthotopic rat bladder cancer model, NAC-AITC administered orally at 10 μmol/kg body wt inhibits cancer growth by 40% and muscle invasion by 49%.

The anticancer activity of NAC-AITC is associated with the modulation of several important molecular targets, including downregulation of both α-tubulin and β-tubulin which are correlated with increased tumorigenesis, tumor invasiveness, activation of caspase-3 in the promotion of cancer apoptosis and downregulation of vascular endothelial growth factor in the establishment of new blood vessels for the bladder cancer to grow and proliferate..

These results are coincidently similar to those shown previously for AITC and are consistent with the understanding that NAC-AITC is a carrier of AITC.

After taking into account of all co and confounds and the result of the previous study, Dr.Bhattacharya A the lead author once again said, "comparison of the pharmacokinetic and physical properties of NAC-AITC with those of AITC suggests that NAC-AITC is superior to AITC for potential use for prevention and therapy of bladder cancer".

Taken altogether, Phytochemical Allyl isothiocyanate may be considered a functional phytochemical in the prevention of bladder cancer and combined with primary therapy for the treatment of bladder cancer, depending to the large and multi-center in the human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
1. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination by Bhattacharya A, Li Y, Shi Y, Zhang Y(PubMed)
(2) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer by Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y.(PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
(4) Chronic inflammation and bladder cancer by Michaud DS. (PubMed)

Herbal Anise, The Herbal Remedy Which Protects Our Body Against Viral Infectious Diseases

By Kyle J. Norton

Herbal Anise may be the next potential target to identify the single ingredient medicine for the treatment of viral infection, some scientists suggested.

Infection is a condition caused the invasion of stimuli and micro pathogens, including the viral infection.

Viral infection is a disease caused by the successful entering and multiplying of a virus in the body.

Anti-viral effects is an act of certain substances to cause the destruction of a virus.

In the acute phase of viral infection, depending on the types of virus, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,

The viral infection o\has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.

The white blood cells in the systematic immune response in the acute phase of infection stimulate the production of the proinflammatory cytokines to the site of infection with an aim to protect our body by killing off the invaders.

The battle between the immune white blood cell and viral invaders in most cases an in the flavor of the side of the immune system, the invaders are killed and the infection is healed.

However, if the immune system can not kill off the invaders with 3 - 8 weeks, it then will adapt to the change, leading chronic inflammatory and infectious diseases.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.

The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.

Besides the main ingredient Anethole, herbal Anise also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the finding a natural antiviral ingredient or whole without inducing any side effects, researchers examined 3 antiviral and immunostimulating substances (LC1, LC2 and LC3) isolated from a hot water extract of seeds of Pimpinella anisum (herbal Anise).
The isolated substances were found to significantly anti antiviral activities against herpes simplex virus types 1 and 2 (HSV-1 and -2), human cytomegalovirus (HCMV) and measles virus.

Application of LCs interfered with virus adsorption to the host cell surface and directly inactivate viruses.

The result indicated that the isolated compound protected the cell membrane against the penetration of the virus in the initiation of the first phase of infection.

Furthermore, injection of LCs also prevents the overexpression of protein associated with macrophages infected. In other words, PCs protects the white blood cells associated with the first line of the immune response against the viral invasion.

The results also inhibited the overproduction of the inflammatory cytokines in the acute phase of infection.

Dr. Lee JB, the lead author said, " lignin-carbohydrate-protein complexes from P. anisum possessed potency as functional food ingredients against infectious diseases".

Moreover, the University of Heidelberg investigated the effect of anise oil, dwarf-pine oil and chamomile oil against different thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinase-negative (aciclovir-resistant) herpes simplex virus type 1 (HSV-1) strains also suggested that essential oil from herbal Anise displays a strong effect against tested viruses.

At maximum noncytotoxic concentrations of the Anise essential oils, significantly reduced the plaque formation by 96.6-99.9% when herpesviruses were preincubated with drugs before attachment to host cells.

Adding essential oil during the replication phase completely wiped out the possibility of viral infectivity.

Compared to the conventional medicine aciclovir, which is effective after attachment inside the infected cells, anise oil affected the virus by interrupting adsorption of herpesviruses and in a different manner.

The findings suggested that herbal Anise essential oils are capable of exerting a direct effect on HSV and might be useful in the treatment of drug-resistant viruses.


Taken all together, herbal anise may be considered a functional herb for the prevention and an adjunct therapy combined with primary medicine for diseases associated with viral infection.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum. by Lee JB, Yamagishi C, Hayashi K, Hayashi T.(PubMed)
(2)Efficacy of anise oil, dwarf-pine oil and chamomile oil against thymidine-kinase-positive and thymidine-kinase-negative herpesviruses by Koch C, Reichling J, Kehm R, Sharaf MM, Zentgraf H, Schneele J, Schnitzler P.(PubMed)

Herbal Catnip, The Potential Anti Chronic inflammatory Diseases Remedy

By Kyle J. Norton

Scientists may have found a natural ingredient in reducing the risk and treatment of chronic inflammatory diseases, some studies suggested.

Inflammation is a systematic immune response caused by the production of proinflammatory cytokine activated by the white blood cells in the immune system responsible for the first line of defense.

In the early phase of bodily injury and damage, the reaction of the immune system also encompasses a wide range of pathophysiological responses to minimize tissue damage while enhancing the repair process.

Inflammation also can be caused by viruses and bacteria, some of the most common stimuli of inflammation by either entering or destroying the host body cells or producing endotoxins, respectively.

Malfunctioning immunological responses attack the body tissue can incite an inappropriate and chronic inflammation.

Believe or not, tissues die from a lack of oxygen or nutrients can also cause inflammation.

Chronic inflammation in another hand, caused by the immune response that can not kill off all infectious agents in the acute phase of infection. 

Some researchers argued that the evolution of the immune system is to kill off all infectious stimuli or pathogen within 3 - 8 weeks, otherwise, the immune system will adapt to their existence, in another word, chronic inflammation.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The plant has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation stimulates sweating, promote menstruation, etc.

Besides the major constituent of terpenoid nepetalactone, herbal catnip also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Thymol, Nepetalactone, Nepetalactone, etc.

On finding an effective anti-inflammatory natural ingredient or whole food with little or side effects, researchers at the Bangabandhu Sheikh Mujib Medical University examined herbal Catnip antinociceptive and anti-inflammatory activities.

A total of 24 male Wister rats weighing 225 ± 25 gm were included in the study, the experimental groups. were randomly injected with essential oil of NP intraperitoneally at the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg with control rats received equal volume (2 ml/kg) of normal saline.

All the doses of essential oil of herbal Catnip showed a strong antinociceptive activity compared to the control.

The highest dose of 200 mg/kg reduced the pain sensation in the tail flick (p <0.01), according to the formalin test.

Injection of the dose at 100 and 200 mg/kg significantly reduced the inflammation in tested subjects paw edema.

These results suggested that the natural ingredient of herbal Catnip essential oil may minimize both the acute and chronic forms of nociception and may have a potential role against inflammation.

Furthermore, the study by the Tarbiat Modares University to evaluate the similar effect of Catnip filed a similar result.

Using the tail-flick and formalin test pain models and the paw edema model of inflammation similar those of the above study in the male Wistar rats, application of essential oil dose-dependently produced analgesia in the acute pain models, including the tail-flick and the first phase of the formalin test.

In the late phase of the formalin test, as a model of chronic pain, the essential oil significantly reduced the pain-induced behavior.

Injection of essential oil exerted a potent anti-inflammatory effect found in the in the formalin-induced paw inflammation model and significant reduction of the paw edema in all applied doses.

The efficacy of herbal Catnip essential oil inhibited both the acute pain and chronic pain and inflammation probably were attributed to its interaction with both central and peripheral nervous system.

Taken altogether, Herbal Catnip may be considered an anti-inflammatory herbal medicine for the prevention and combined with the primary therapy for the treatment of chronic inflammatory disease without inducing any side effect.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)

Herbal Calendula, the Natural and Potent Neuroprotective Functional Herb

By Kyle J. Norton

Herbal Calendula may have a potential and profound effect in protecting the neurons integrity against the onset of neuroprotective effects.

Neuroprotective effect is a protection against the damage of the brain cells.

The nerve system is a complex network including the brain and spinal cord with a unique function in transmitting information or signals from and to the brain and spinal cord from different parts of the body.

The nerve system in the human has evolved over thousands of the year to enhance the survivals of the human species by the rapid response to the change of the environmental factors and adapting to the change of environment.

The causes of neuro diseases are associated with the damage or dysfunction of the central nervous system (CNS), including the brain, brainstem, and spinal cord.

However, some of the most common causes of neuro diseases are associated with neurotoxicity, the term which refers to damage to the brain or spinal cord caused by exposure to natural or man-made toxic substances, leading to gradual loss of neurons that interfere with the function of the nerve system in transmitting information to other parts of the body.

There are many factors associated with the onset of neurotoxicities, such as characteristics of the neurotoxin, the doses of exposure, and the ability to metabolize and excrete the toxin.

Accumulation of toxic chemicals over the long-term in the nerve system can overwhelm the protective factors, leading to neurotoxic symptoms of paralysis or weakness in the limbs. altered sensation, tingling, and numbness in the limbs, prolonged headache, and vision loss, depending on the brain area of toxicity.

In elderly, the neuro-toxicity is also found to speed up the onset of neurodegenerative diseases, leading to symptoms of loss of memory and cognitive dysfunction, such as Alzheimer's disease.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herbal plant has been used in traditional medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

In the concern that oxidative stress (OS) and nitric oxide mechanisms proposed in 3-nitropropionic acid (3-NP)-induced neurotoxicity, scientists at the Sree Siddaganga College of Pharmacy examined the antioxidant, anti-inflammatory and estrogenic effects of Calendula officinalis Linn. flower extract (COE) neuroprotective against the experimental model.

The study included numbers of rat induced neurotoxicity by the injection of  3-NP.

Observing behavioral changes, OS and striatal damage in rat brain suggested that neurotoxic rat was accompanied by significant alterations in animal behavior, oxidative defense system evidenced by raised levels of LPO and nitrite concentration, and depletion of antioxidant levels.

These examinations showed that 3-NP caused a significant damage to the rat brain by increasing expression of free radicals and suppressing production of antioxidant enzymes by the host body.

The injection also enhanced the production of inflammatory cytokines which have a strong effect in the blood vessels constriction and the loss of neuronal cells in the striatal region

Application of the herbal extract significantly attenuated behavioral alterations, oxidative damage and striatal neuronal loss in 3-NP-treated animals.

These results showed that COE is protective against 3-NP-induced neurotoxicity in rats through its antioxidant, anti-inflammatory and estrogenic properties.

With an aim to determine the effect of Calendula officinalis Linn. flower extract (COE) in the inhibition of excess monosodium glutamate (MSG), a popular flavor enhancer used in food industries in the induction of neurotoxicity, researchers conducted an experiment to evaluate the neuroprotective effect of COE on MSG-induced neurotoxicity in rats.


Adult Wistar rats selected to the study were administered systemically for 7 days with MSG and after one h of MSG injection before treated with COE (100 and 200 mg/kg) orally.

Before treated with COE, infected rat showed a significant alteration in animal behavior, oxidative defense (raised levels of LPO, nitrite concentration, depletion of antioxidant levels) and hippocampal neuronal histology.

These result indicated that MSG displays similar effects to those of 3-NP in facilitating the imbalance of the ratio of the free radicals and antioxidant enzymes in the tested rats.

Observation of the result after injection of COE, researchers found that COE only restores the balance of the free radicals and antioxidant ratio but also inhibits the death of neuron cells in the brain.

The neuroprotective effect of COE was attributed to the antioxidant and anti-inflammatory properties, suggested by Dr. Shivasharan BD, the lead scientist.

Taken altogether, Herbal Calendula may be considered a functional herb for the prevention of neurotoxicity and an adjunct therapy combined with the primary medicine for the treatment of neuro diseases induced by toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats by Shivasharan BD1, Nagakannan P, Thippeswamy BS, Veerapur VP, Bansal P, Unnikrishnan MK(PubMed)
(2) Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats by Shivasharan BD, Nagakannan P, Thippeswamy BS, Veerapur VP(PubMed)

Apricot, the Most Prominent Fruit for the Prevention and Treatment of Pancreatic Cancer

By Kyle J. Norton, Master of Nutrition

Apricot may have a potential for the cure of pancreatic cancer without inducing any side effects, some scientists suggested.

Pancreatic cancer is a chronic condition caused by irregular cell growth in the tissue of the pancreas.

Most primary pancreatic cancer starts with the alternated DNA cells on the surface of the inner lining of the pancreas organ.

At the advanced stage, the malignant cells in the pancreas can travel a distance way to infect other tissue and organ through lymph and blood.

Including all the stages, the 5 years survival rate of pancreatic cancer is 7% and it is considered the most rapidly fatal cancer.
Most people at the early stage of pancreatic cancer do not experience any symptoms. However, at the later stage, as the tumor has grown large enough, it can suppress the nearby tissue and nerve cells, leading to localized symptoms and severe pain.

The exact causes of pancreatic cancer are unknown. Age, gender, race, family history. and inherited genetic syndromes were found to associate to the risk factor of the onset of the disease, epidemiologically.

Some researchers suggested that the most common risk factors that cause the development of pancreatic cancer are found in patients associated with a history of tobacco use and obesity.

Dr. Alguacil J in the study to examine the association between noncigarette tobacco use (i.e., cigars, pipes, smokeless tobacco) and pancreatic cancer risk among nonsmokers of cigarettes, said, "Cigarette smoking is an important and well-established cause of pancreatic cancer." and "Long-term use of smokeless tobacco (i.e., >20 years) was also associated with a nonsignificant increased risk" and "heavy use of smokeless tobacco, and to a lesser extent, cigar smoking may increase the risk of pancreatic cancer among nonsmokers of cigarettes".

These result suggested cigarettes and noncigarette smoking are associated with the increased risk of pancreatic cancer in a type-dependent manner.

In the obesity front, Dr, Michaud DS in the study "Obesity and Pancreatic Cancer" said, "obesity early in adulthood is strongly associated with future risk of pancreatic cancer and that abdominal obesity is an independent risk factor. There is increasing evidence suggesting long-standing diabetes type 2 and insulin resistance are important etiological factors of this disease, providing a strong mechanistic link to obesity".

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae.

Apricot is classified with the family of the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

The chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.

The research team on cancer program at the Shimane University showed that MK615 produced from Japanese apricot and contains several cyclic triterpenes, such as oleanolic and ursolic acids may have an effect in the inhibition of pancreatic cancer.

The experiments were performed on several human cancer cell lines exposed to MK615 for 7 days and in vivo growth of human pancreatic cancer MIAPaCa-2 cells.

Application of MK615 inhibited the growth of several human cancer cell lines in a concentration-dependent way.

Pancreatic cancer MIAPaCa-2 cells were highly sensitive to the growth-inhibiting effects of MK615. 

Treatment with MK615 preferentially induced cell death in human cancer cells without causing harm to the nearby cells such as human umbilical vein endothelial cells (HUVEC) and mouse bone marrow cells.

MIAPaCa-2 cells incubated with MK615 in the presence of antioxidant, growth-inhibition was significantly reduced.

MK615 induced the accumulation of reactive oxygen species in the exertion of cytotoxicity to the cancer cells but not in HUVEC. 

Finally, researchers also found that MK615, in both the presence and absence of gemcitabine, significantly inhibited the growth of human pancreatic cancer cells as xenografts without apparent adverse effects.

The findings suggested that MK615, a supplement produced from Japanese apricot, processes a potential and therapeutic value in treating pancreatic cancers through a reactive oxygen species-dependent mechanism.

The study was published on the National Institutes of Health

Taken altogether, Apricot with abundant bioactive compounds such as oleanolic and ursolic acids may be considered a functional fruit for the prevention and an adjunct therapy combined with primary medicine for the treatment of pancreatic cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



(1) Antitumor effect of Japanese apricot extract (MK615) on human cancercells in vitro and in vivo through a reactive oxygen species-dependent mechanism by Hattori M1, Kawakami K, Akimoto M, Takenaga K, Suzumiya J, Honma Y. (PubMed)
(2) Smokeless and other noncigarette tobacco use and pancreatic cancer: a case-control study based on direct interviews by Alguacil J1, Silverman DT. (PubMed)
(3) Obesity and Pancreatic Cancer by Michaud DS. (PubMed)