Herbal Calendula, the Potent Anti Edema Functional Remedy

By Kyle J. Norton

Herbal Calendula may have a potential effect in reducing risk and treatment of edema, some scientists suggested.

Edema is a condition characterized by an abnormal accumulation of fluid in certain tissues within the body due to injury or inflammation.

In most cases, edema occurs under the surfaces of the skin in the leg and ankle. However, fluids can also be accumulated in the lungs (pulmonary edema).

Without the assistance of diagnosis, researchers can not pinpoint the exact causes of edema.

There are numbers of risk factor associated with the onset of the swellings, such as low levels of albumin that keeps the blood in the vessels, allergic reaction, blood clots. Some medical conditions such as congestive heart failure, kidney diseases and long-term intake medicine such as NSAIDs and calcium channel blockers also increased the risk of edema.

Some researchers suggested that under normal conditions, medicine that removes excess fluid and reduces intake salt can be effective. However, if the condition of edema is caused by underlying disease, separated medicine treatment may be required.

If you are experiencing symptoms of heavy leg and ankle and shortness of breath, please check with your doctor to rule out the edema possibility.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.


Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

In the study to examine the anti-inflammatory effect of Calendula officinalis flower extract against paw edema, researchers at the Amala Cancer Research Centre, launched an investigation in the paw edema of animals induced by carrageenan and dextran.

Oral injection of 250 and 500 mg/kg body weight of Calendula extract exerted a significant inhibition (50.6 and 65.9% respectively) in paw edema of animals by 41.9% in the carrageenan group and 42.4% in the dextran group, respectively through the anti-inflammatory activity.

In chronic inflammatory model induced by injection of formalin, administration of 250 and 500 mg/kg body weight of Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls.

Further examination also found that proinflammatory cytokines activated by macrophage of the immune system in the response to infection are also reduced significantly.

Other proinflammatory proteins such as IL- 1beta, IL-6, TNF-alpha and IFN-gamma and acute phase protein, C- reactive protein (CRP) in edema mice produced by LPS injection were inhibited significantly by the extracts in different doses. 

These results suggested that herbal Calendula inhibits edema caused by inflammation through its anti-inflammatory expression.

Additionally, in the study to reaffirm the efficacy of Calendula anti-inflammation against the progression of edema, researchers at the niversità di Trento conducted a differentiation on the anti-inflammatory chemical constituents of the herb.

13 out of 15 terpenoids from Calendula were found to process topical anti-inflammatory activities with respect to the inhibition of croton oil-induced ear edema in the mouse.

Three derivatives of Rings A, D, and E of faradiol, the C(16) benzyl ether 15, the C(30) aldehyde 24, and the C(30) primary alcohol 25 isolated from the herb also showed a significantly improved anti-inflammatory potency.

Taken altogether, herbal Calendula with the abundant anti-inflammatory bioactive compounds may have a potential effect in the prevention and treatment of inflammatory edema.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Phytochemical Constituents and PharmacologicalActivities of Calendula officinalis Linn (Asteraceae): A Review by BP Muley, SS Khadabadi and NB Banarase (Tropical Journal of Pharmaceutical Research)
(2)Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action by Preethi KC, Kuttan G, Kuttan R.(PubMed)
(3) Improved anti-inflammatory activity of three new terpenoids derived, by systematic chemical modifications, from the abundant triterpenes of the flowery plant Calendula officinalis by Neukirch H, D'Ambrosio M, Sosa S, Altinier G, Della Loggia R, Guerriero A.(PubMed)

Arctostaphylos uva-ursi, the Herbal Remedy Which Kills Bladder Cancer Cells in Vitro, Scientists Say

By Kyle J. Norton

Herbal Arctostaphylos uva-ursi may have a potential in the prevention and treatment of bladder cancer, some scientists suggested.

Bladder cancer is a medical and chronic condition characterized by cell growth uncontrollably and disorderly in the tissue of the bladder.

Most bladder cancer starts first on the surface of the inner lining tissue of the bladder. As the cancer progress to the advanced stage, the malignant cells can infect other healthy tissue through the circulation of blood and fluid.

Bladder cancer that spreads to other parts of the body is known as metastatic bladder cancer.

According to the statistic, every year, approximately, over 80,000 adults, including 62,380 men and 18,810 women in the United States are diagnosed with bladder cancer, causing the of deaths of 12,520 men and 4,720 women.

 The 5-year relative survival rate of all stages of bladder cancer is about 77%. However, the 5-year relative survival rate for people diagnosed with stage 0 of bladder cancer is about 98%,

The statistic strongly suggested, if bladder cancer is diagnosed in the early stage, it is treatable.

The exact causes of bladder cancer are unknown. However, the age of 50 and over, men, smoking, long-term exposure to harmful chemicals are associated with the increased risk of the disease,

Some researchers suggested certain medical conditions such as diabetes, previous treatment of radiotherapy and chemotherapy and early menopause are also some of the prevalent risk factors that may increase the early onset of bladder cancer.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

The Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides and flavonoids.

In the reaffirm of traditional medicine use of herbal Arctostaphylos uva-ursi for treatment of various types of cancer, researchers at the Chung-Ang University College of Medicine launched an investigation to examine the effects of Arbutin, a glycosylated hydroquinone extracted from the bearberry plant (Arctostaphylos species) on TCCSUP human bladder carcinoma cell.

At the dose at concentrations of < 500 microg/ml, Arbutin did not exhibit any cytotoxic effects in TCCSUP cells.

In different concentrations that are higher than 500microg/ml, Arbutin significantly decreased TCCSUP cell proliferation in a time-dependent manner.

According to the cell cycle analysis, arbutin strongly disrupted the cell cycle also in a time-dependent manner.

Furthermore, arbutin led to the inactivation of the extracellular signal-regulated kinase (ERK), which is known to critically regulate cell proliferation.

The in-depth analysis also found that arbutin markedly increases the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1)which is considered a key mediator of p53-dependent cell cycle arrest.

Where p53, also known as TP53, is a protein which processes a function in regulating the cell cycle division and hence functions as a tumor suppression.

Dr. Li H, the lead author, after taking into account of co and confounders, said, " arbutin inhibits TCCSUP cell proliferation via ERK inactivation and p21 up-regulation".

Abnormal activation of ERK was found to in human cancer due to DNA mutation. The combination of ERK pathway inhibitors (cytostatic agents) and conventional anticancer drugs (cytotoxic agents) are an excellent basis for scientists to develop new chemotherapeutic strategies against cancer.

Taken altogether, herbal Arctostaphylos uva-ursi containing a high volume of Arbutin may be considered a functional herb for the prevention and combined with conventional medicine for treatment of bladder cancer,

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Arctostaphylos uva-ursi anti-bladder cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Arbutin inhibits TCCSUP human bladder cancer cell proliferation via up-regulation of p21 By Li H, Jeong YM, Kim SY, Kim MK, Kim DS.(PubMed)

Purple Carrot, the Functional Veggie Which Protects Us Against the Onset of Metabolic Syndrome

By Kyle J. Norton, Master of Nutrition

Scientists may have found a juice which processes a potential effect in reducing the risk of metabolic syndrome, the major cause of heart disease, diabetes, and stroke, some studies found.

Metabolic syndrome is a cluster of at least three of the five following medical conditions including high blood pressure and sugar, central obesity, abnormally high levels of blood cholesterol or triglyceride levels.

In the US, approximately, a quarter of the adult population has metabolic syndrome. 

Some researchers suggested, metabolic syndrome is likely associated with a genetic preposition 

However, Dr. Stančáková A, the lead author at the University of Eastern Finland in the research of the linkage of genetics in risk of metabolic syndrome, said, "GWA studies for the individual components of the MetS have reported several loci having pleiotropic effects on multiple MetS-related traits" and "Genetic studies have provided only limited evidence for a common genetic background of the MetS".

Other risk factors such as an unhealthy diet and lifestyle, increases with age, with racial and ethnic minorities are also associated with the onset of the condition.

Truly, in the study conducted by the joint study lead by the Leighton Hospital, wrote, "... there was a high prevalence of poor diet, smoking, and inadequate exercise. Many did not follow national recommendations for dietary intake of fruit and vegetables and daily exercise. These factors probably contribute to the high prevalence of metabolic syndrome".

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe. 

In the differentiation of the effect of purple vegetable in the risk of metabolic syndrome in the animal model, the University of Guelph conducted an evaluation to examine the effect of substitution of the majority of carbohydrate in a high-fat diet with purple potatoes (PP) or purple carrot (PC), for 8 weeks in obese Zucker rats.

After 8 weeks, according to the assay used in the studies, the substitution of PC improved insulin resistance and hypertension, major components of metabolic syndrome, compared to the control.

Dr, the lead author said, "incorporation of purple vegetables in functional food products may provide metabolic/cardiovascular benefits in the background of a high-fat diet that promotes obesity" However, "The bioactives in the vegetables responsible for blood pressure and glucose homeostasis could be different, and their effects could be independent of each other. The specific bioactives of each vegetable and their molecular targets remain to be identified".

This bioactive compound was found to be anthocyanins, a major component in the purple carrot juice.

In the evaluate whether anthocyanins, phenolic acids, and carotenoids, the predominant phytochemicals presented in purple carrots may be used in the treatment of the metabolic syndrome, researchers at the The University of Queensland launched an investigation to examine the activity of anthocyanins in rats fed a high-carbohydrate, high-fat diet as a model of the metabolic syndrome induced by diet.

Before injection with carrots juice, high-carbohydrate, high-fat diet-fed rats were found to develop many conditions associated the similarity to those of metabolic syndrome, including hypertension, cardiac fibrosis, increased cardiac stiffness, endothelial dysfunction, impaired glucose tolerance, increased abdominal fat deposition, altered plasma lipid profile, liver fibrosis and increased plasma liver enzymes together with increased plasma markers of oxidative stress and inflammation as well as increased inflammatory cell infiltration.

Application of purple juice at the end of the experiment attenuated or reversed all the changes while β-carotene isolated from the juice did not reduce oxidative stress, cardiac stiffness or hepatic fat deposition.

Further analysis of the concentration of the purple carrot juice, researchers wrote, "the juice itself contained low concentrations of carotenoids, it is likely that the anthocyanins are responsible for the antioxidant and anti-inflammatory properties of purple carrot juice to improve glucose tolerance as well as the cardiovascular and hepatic structure and function".

These result suggested that anti-metabolic syndrome of purple carrot juice was attributed to the effect of a single bioactive compound, namely, anthocyanins.

Taken altogether, purple carrot juice containing a high amount of anthocyanins may be considered a functional food and secondary therapy  for the prevention and treatment of metabolic syndrome without inducing any side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparison of purple carrot juice and β-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome by Poudyal H1, Panchal S, Brown L.(PubMed)
(2) The Effect of Anthocyanin-Rich Purple Vegetable Diets on Metabolic Syndrome in Obese Zucker Rats by Ayoub HM1, McDonald MR2, Sullivan JA2, Tsao R3, Platt M1, Simpson J1, Meckling KA1.(PubMed)
(3) Genetics of metabolic syndrome by Stančáková A1, Laakso M.(PubMed)
(4) Lifestyle factors and the metabolic syndrome in Schizophrenia: a cross-sectional study by Adrian Heald,1,2 John Pendlebury,3 Simon Anderson,4 Vinesh Narayan,3 Mark Guy,5Martin Gibson,2 Peter Haddad,3 and Mark Livingston. (PMC)

@Herbal Chamomile, The Potential Anti Acute and Chronic Dermatitis Remedy With No Side Effects

By Kyle J. Norton, Master of Nutrition

Scientists may have found a herbal medicine in the treatment of dermatitis, without inducing any side effects, some studies suggested.

Dermatitis or eczema is a group of diseases characterized by the inflammation of the skin.

There is no single cause of eczema, anything that we face every day can trigger a dermatitis flare, including stress, irritants, climate change, and sweating. However, infection and allergens.are considered the most common causes of the disease.

In the study "Diet and Dermatitis: Food Triggers,  Dr. Rajani Katta, and colleagues at the Baylor College of Medicine, wrote, "Research has found that dietary factors can indeed exacerbate atopic dermatitis or cause dermatitis due to systemic contact dermatitis. In atopic dermatitis, dietary factors are more likely to cause an exacerbation among infants or children with moderate-to-severe atopic dermatitis relative to other".

This statement indicated a significant effect of foods that can trigger rapidly the immunoglobulin E-mediated hypersensitivity reactions,  leading to the late eczematous reaction.

The symptoms of the disease include itchiness, red skin, and a rash. However, long-term dermatitis can cause skin thickening

Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

In the study to reaffirm the traditional use of German chamomile (GC) oil for the treatment of skin disorders, researchers at the Howon University launched an investigation of BALB/c mice sensitized twice a week with 100 microL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice the following week with 100 microL of 0.2% DNCB for atopic dermatitis induction before applying 3% GC oil daily (70 microL, 6 times week) on the dorsal skin for 4 weeks.

Saline or jojoba oil was used for the control mice.

Blood examples collected at 2 and 4 weeks after initiating oil application, researchers found that
* Serum IgE levels were significantly lowered in the GC oil application group at the end of the 4-week application period compared to control groups.

* The GC oil application for 4 weeks results in serum IgG1 level compared with that after 2-week application.

* The GC oil application group showed a significantly lower serum histamine level than the control group 2 weeks after oil application.

* Symptoms of scratching frequency of the GC oil application group was significantly lower than either control groups.

These results suggested that GC oil's immunoregulatory potential for alleviating atopic dermatitis through the influencing of Th2 cell in the inflammatory response.

Additionally, in the examination of concomitant desire to use natural products to treat skin conditions, researchers launched an investigation to review the scientific and clinical studies in the evaluating composition and clinical usefulness of natural products in the treatment of inflammatory skin dermatoses.

Chamomile is found to process a significant effect in erythema induced by ultraviolet light, rosacea, atopic dermatitis, sensitive and irritated skin, drug-induced skin eruptions, and psoriasis, compared to
colloidal oatmeal, feverfew, licorice, aloe vera, chamomile, and turmeric

Dr. Wu at the final report, said, "These products may be particularly well suited as alternatives to pharmacologic therapies in chronic conditions for which long-term use is required".

Taken altogether, Chamomile processed  anti-inflammatory activity may be particularly well suited as alternatives to pharmacologic therapies in chronic dermatitis for which long-term use is required

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.by Lee SH1, Heo Y, Kim YC.(PubMed)
(2) Anti-inflammatory ingredients by Wu J.(PubMed)
(3) Diet and Dermatitis: Food Triggers by Rajani Katta, MD and Megan Schlichte, BSc(PMC)

Herbal Catnip, the Herbal Remedy Which Improves Memory Naturally

By Kyle J. Norton, Master of Nutrition

Herbal Catnip (Nepeta cataria) may process a significant effect in improving memory, some scientists suggested.

Memory is the faculty in which information is stored and processed.

About 90% of all the brain’s neurons are located in the cerebral cortex, mainly in the "grey matter", including the prefrontal cortex, which plays an important role in processing short-term memories and retaining longer term memories.

Short-term memory is a capacity to hold a short information in mind in an active, ready to be used for a short period of time.

Longer term memories are held in the brain indefinitely. 

The most causes of memory loss are associated with physical injury to the brain and neurodegenerative diseases, including Alzheimer's or Huntington's disease.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation stimulates sweating, promote menstruation, etc..

In the aim to reaffirm the statement that plants and vegetables with antioxidant activity can reduce oxidative damages in the brain and improve cognitive functions, researchers at the Qom University of Medical Sciences conducted an examination of the effects of Nepeta (Catnip) menthoides aqueous extract on memory retention and retrieval of mice by using passive avoidance apparatus.

By doses: 100, 200, 400 and 800 mg kg(-1), Nepeta menthoides aqueous extract significantly increased memory retention and retrieval.

The best response to memory retention and retrieval was achieved by a dose of 800 mg kg(-1) of Nepeta extract,

Further analysis suggested that the effects of Nepeta extract, in enhancing memory were attributed to the antioxidant activity of its components such as rosmarinic acid, caffeic acid, and phenolic acids.

Additionally, in the study to evaluate the nootropic activity of essential oil of Nepeta cataria (EONC)  in  scopolamine (0.4 mg/kg, i.p.) induced amnesia in mice, using elevated plus maze and passive avoidance paradigm to observe the learning and memory parameters, researchers found that

* Application of the essential oil (1gm/kg) significantly attenuated memory deficits induced by scopolamine (0.4 mg/kg, i.p.) and natural aging. 

* Also, treated aging mice exhibited a decreased transfer latencies and increased step down latencies significantly.

* The anti memory deficits effect of Nepeta cataria were attributed to the influence on central cholinergic activity, including arousal, attention, memory, and motivation, by estimating the whole brain acetylcholinesterase activity in the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters.

Dr. Sease. Satish S. at the final report said, " essential oil of Nepeta cataria might prove to be a useful memory restorative agent in the treatment of dementia seen in elderly".

Taken altogether, herbal Catnip and its essential oil may be considered a secondary therapy for improvement of memory or combined with conventional medicine for prevention of the progressive loss of memory in elderly with neurodegenerative disease.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)
(3) Studies on Therapeutic Potential of Essential Oils of Nepeta Cataria in Treatment of Alzheimer’s Disease by Satish S. (Asian Journal of Biomedical and Pharmaceutical Science)

Herbal Calendula (Calendula officinalis), May Process the Potency for Chronic Blepharitis

By Kyle J. Norton

Herbal Calendula may have a potential effect in reducing risk and treatment of chronic blepharitis, some scientists suggested.

Blepharitis is a condition caused by the eye inflammation of the eyelids or parts of the eyelids as a result of clogging of tiny oil glands located near the base of the eyelashes, affecting people of all ages.

Blepharitis can be classified into 2 types

1. Acute blepharitis is referred to eyelid infection by bacterial, viral, or parasitic pathogens.

2. Chronic blepharitis or lid inflammation is caused by staphylococcal, seborrheic, and meibomian gland dysfunction (MGD) that lasts more than 3 months.

According to researchers, chronic blepharitis is difficult to treat due to persistently low-grade inflammation.

The most common causes of blepharitis are the bacterial infection. However, the condition also can be caused by a skin condition, such as scalp dandruff or rosacea.

If you experience symptoms of itchiness, redness, flaking, and crusting of the eyelids, burning sensation, irritation, tearing, and red eyes, you may have acute blepharitis, please check with your doctor.

Untreated chronic blepharitis can lead to permanent alterations to the eyelid margin or vision loss from superficial keratopathy (abnormality of the cornea), corneal neovascularization, and ulceration.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.


Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

In the findings of the natural ingredient with a potential for treatment of chronic blepharitis without inducing any adverse effects, Dr. Prozornaia LP and Dr. Brzhevskiĭ VV.launched an investigation to examine the herbal Calendula anti chronic blepharitis activity.

In the total of 110 patients aged from 3 to 42 years old were examined to estimate the efficacy of chronic blepharitis treatment, 50 patients are with chronic blepharitis and dry eye syndrome (DES), 28 are with DES due to computer vision syndrome and 32 are with isolated chronic blepharitis.

All patients received eyelid massage and a complex of hygienic procedures was performed using phytoproducts ("Geltec-Medika", Russia): blepharoshampoo, blepharolotion, blepharogel 1 and 2.

After all the procedures were finished, moist warm pads (with blepharolotion and calendula extraction) were applied on the eyelids in 25 patients.

In compared to massage, moist warm pads treatment exerts a significant effect in the improved efficacy of background therapy in patients with meibomian gland hypofunction but the insignificant effect in patients with excessive meibomian gland secretion.

These result suggested that Herbal Calendula may be effective in the treatment of chronic blepharitis caused by meibomian gland hypofunction if it is used in conjunction with eyelid hygiene.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) [Efficacy of physiotherapy and hygienic procedures in the treatment of adults and children with chronic blepharitis and dry eye syndrome].[Article in Russian] by Prozornaia LP, Brzhevskiĭ VV.(PubMed)
(2) Interventions for chronic blepharitis by Kristina Lindsley,1 Sueko Matsumura,1 Elham Hatef,2 and Esen K Akpek. (PubMed)

Green Tea Polyphenols (GrTPs), the Bioactive Ingredient Which Protects Sperm Quality and Integrity Against Infertility, Scientists Find

By Kyle J. Norton, Master of Nutrition

Scientists may have found a beverage bioactive compound that protects the sperm quality and integrity, without inducing any side effects, some studies found,

Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who cannot carry the pregnancy to term are also considered as infertile.

According to the statistic, approximately 10% of women in their reproductive years are having the difficulty of conceiving or carrying the pregnancy to term. 

Most common causes of infertility in men are low sperm count, sperm motility and abnormal sperm.

What causes the abnormal sperm production is unknown. Researchers do not know why people with the same health conditions and family history, some are having abnormal sperm production while others do not.  

However, researchers do not that certain prevalent risk factors including physical and medical condition, such as undescended testicle and diabetes long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance such as testosterone deficiency are associated with abnormal sperm production.

Genetic preposition such as chromosomal conditions that affect sperm production also plays a major role in elevating the onset of abnormal sperm production.

Age, obesity, use of the illicit drug, excessive alcohol drinking and long-term exposure to chemicals are the common causes of abnormal sperm production.

In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and men's fertility: does diet affect sperm quality?" wrote, "men may be encouraged to use antioxidant supplements and to follow dietary patterns favoring the consumption of seafood, poultry, nuts, whole grains, fruits, and vegetables. Evidence is strongest for recommending the use of antioxidant supplements to men in couples undergoing infertility treatment-although the specific antioxidants and doses remain unclear-and increasing consumption of omega-3 fatty acids from fish and nuts".

These results suggested that men who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food and less in fruits, nuts and vegetables are at the higher risk of sperm abnormality.

In the concerns of highly sensitive of sperm cells to reactive oxygen species (ROS), which are produced during cellular oxidation, researchers at the joint study led by the Anhui Agricultural University launched an investigation to examine the green tea polyphenols (GrTPs) effect in the protection of the integrity of the sperm.

Before application of green tea s (GrTPs) researchers found that oxidative stress has numerous effects, in the increased apoptosis, reduced motion parameters, and sperm integrity in the tested subjects with overexpression of free radicals.

The increased ROS levels probably are the results of antioxidants enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.

Oral administered green tea polyphenols (GrTPs), showed to restore and increase the quality of male gametes, mostly via the capability of catechins in the reduction of ROS production.

Further analysis also suggested that GrTPs processed antioxidant properties that not only restores the abnormal sperm production caused by overexpression of ROS but also improves major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality.

These unique properties of green tea catechins in improving the male reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in reducing the risk of abnormal sperm quality in many parameters.

Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".

Additionally, in the concerns of the reactive oxygen species (ROS) presented in high concentrations in the genital tracts of males that affects compromised vitality, increased morphological defects and decreased sperm motility, researchers launched an investigation to examine whether green tea catechins protect the sperm quality and integrity over the expression of ROS.

After taking into account levels of oxidative stress before and after application of green tea catechin, researchers wrote,

* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS through its strong antioxidant activity.

* Green tea catechins potentially improve the sperm quality and integrity.

Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".

Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the male reproductive sperm quality and integrity against the onset of infertility.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources

(1) Diet and men's fertility: does diet affect sperm quality? by Nassan FL1, Chavarro JE2, Tanrikut C. (PubMed)

(2) Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review by Rahman SU1, Huang Y2, Zhu L3, Feng S4, Khan IM5, Wu J6, Li Y7, Wang X8.(PubMed)

(3) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)