Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Saturday, 6 October 2018

Green Tea and Its Bioactive EGCG Which Process Anti Bacterial Activity Against the Onset of Atypical Pneumonia, Scientist Find

Kyle J. Norton

Green tea may have a therapeutic and positive effect in protecting the lung against bacterias that cause atypical pneumonia, some scientists suggested.

Atypical pneumonia is an infection of the lower respiratory tract. The disease is accounted for 7%‐20% of community‐acquired pneumonia (CAP).

Most cases of atypical pneumonia are caused by the Streptococcus pneumonia. However, Other bacteria such as Mycoplasma pneumonia, Chlamydia pneumonia, Chlamydia psittaci, and Legionella pneumophila are also found in some patients with atypical pneumonia.

Conventional medicine used for the treatment of typical pneumonia, such as Macrolide antibiotics: Macrolide drugs are the preferred treatment for children and adults. Macrolides include azithromycin(Zithromax®) and clarithromycin may be effective. However, they can induce certain side effects including gastrointestinal discomforts.

The article of Popular Antibiotics May Carry Serious Side Effects BY JANE E. BRODY, in the explanation of a patient who just took on dose of antibiotic, wrote," After just one dose, he developed widespread pain and weakness." and " (He is) unable to walk uphill, climb stairs or see clearly, his symptoms included dry eyes, mouth, and skin; ringing in his ears; delayed urination; uncontrollable shaking; burning pain in his eyes and feet; occasional tingling in his hands and feet; heart palpitations; and muscle spasms in his back and around his eyes".

If you are currently taking antibiotics for the treatment of a disease, please make sure that you discuss the side effects with your doctor.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

With an aim to find the natural solution with antibacterial potential, researchers at the University of Duisburg-Essen conducted a study to examine whether green tea processes antibacterial activity against the onset of infectious diseases.

at the final report of the experiment researcher wrote, the minimum inhibitory concentrations against bacteria were 10–100-fold higher compared to the antiviral property with the same volume.

EGCG used alone or in combination with different antibiotics exerts a significant activity against a number of bacteria including multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus Stenotrophomonas maltophilia, the group of bacteria that cause atypical pneumonia.

The additional analysis suggested that EGCG displays the efficacy in inhibiting bacteria by binding to lipid membranes and affecting the folic acid metabolism of bacteria and fungi by inhibiting the cytoplasmic enzyme dihydrofolate reductase.

Dihydrofolate reductase, or DHFR, an enzyme that reduces hydrofolic acid to tetrahydrofolic acid, plays an essential role in the building of DNA of the cells.

Furthermore, in an aim to find a natural anti antibacterial remedy in replacing the ineffective antibiotics as well as the concerns over the toxicity of the mainstay of treatment against Stenotrophomonas maltophilia, a main cause of atypical pneumonia, researchers at the Barts & The London NHS Trust conducted a study to examine the effect of Epigallocatechin-3-gallate (EGCG), the major catechin found in green tea,against a number of bacteria.

In a total of 40 clinical isolates of S. maltophilia used in the experiment, scientists found that EGCG exerts a promising in vitro antimicrobial activity against S. maltophilia. At the dose of 512 mg/ L., EGCG inhibited bacteria in the range of 50% and 90%.

Moreover, in the examination of tea leaves organic compounds involved in the defense of the plants against invading pathogens including insects, bacteria, fungi, and viruses, researchers showed that tea flavonoids and teas exert great antimicrobial effects against foodborne and other pathogenic bacteria, virulent protein toxins produced by some of the bacteria, virulent bacteriophages, pathogenic viruses, and fungi.

Taken all together, green tea and its bioactive ingredient EGCG may be considered a functional food and supplement respectively in protecting the human body against bacteria, particularly, Streptococcus pneumonia in the initiation of the onset of bacterial infection and infectious diseases, including atypical pneumonia.

Sources
(1) Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea by J Steinmann,1 J Buer,1 T Pietschmann,2 and E Steinmann(PMC)
(2) Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia by Gordon NC1, Wareham DW(PubMed)

(3) Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas Mendel Friedman

Coffee, The Beverage Which Protects Human Cells DNA Against Mutagenesis, Scientists Suggested

By Kyle J. Norton, Master of Nutrition

Caffeinated and decaffeinated coffee intake may have a profound effect in protecting the human healthy cell against mutagens in alternating cell DNA transcripts, some studies suggested.

Mutagenicity is an action characterized by the alternation of the DNA chemically or physically.

In most cases, mutagenicity, in human expressed by mutagens are associated with the onset of irregular cells growth, causing various types of cancer.

Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to the tropical Africa and Madagascar.

In the study of caffeine effect in mutagenesis, coffee and caffeine showed a significant effect in gene mutation in bacteria and fungi, but in high concentrations, they can also express a similarly mutagenic influence to mammalian cells.

In other words, the application of coffee and caffeine can induce the change of the DNA of bacteria, virus, and fungi and human cultured cells

In the microbial environment, the change of DNA sometimes can increase the survival of the microorganisms in adapting to the change of environment. The results can make them more lethal than the previous form.

The findings suggested the duo effect of coffee and caffeine, on one hand, inhibited the gene mutation but on the hand displayed a significant mutagenic DNA damage to living organisms, but less in the human even with a moderated drinking habit.

Also in bacterial experiments, according to the observation from bacteria mutation assays, trigonelline, found in caffeine alone or in combination with most of the single amino acids found in caffeine and mixtures of amino acids, showed a potent mutagenic activity in Salmonella typhimurium strains.

The mutagenic activity of caffeine can be observed through its potentiation in inducing chromosomal aberrations through transforming sublethal damage of mutagenic agents into lethal damage.

Furthermore, the study also revealed that chemically reactive components such as aliphatic dicarbonyls from the caffeine were some of the culprits attributed to this mutagenic exhibition.

But conversely, according to the Chinese Academy of Agricultural Science, intake of caffeinated coffee demonstrated a protective effect in inhibiting these mutagenic activities through theirs' numerous chemicals depending on the time consumption in the presence of the mutagenic agent.

Dr. Wu X, the lead author said, "Trigonelline and amino acids are natural components in green coffee beans. Model systems mimicking coffee roasting were used to produce heated samples of trigonelline, amino acids, and glucose".

Additionally, according to the coffee producing company, Nestlé Research Center, coffee intake has shown a strong effect in the exhibition of the function of enzymes involved in xenobiotic detoxification processes and primary hepatocytes.

In animal study, the experiment also found that coffee induces the mRNA and protein expression of enzymes involved in the promotion of cellular antioxidant defenses.

More importantly, coffee also exhibited chemoprotective effects of against toxic Aflatoxin B1 in the induction of genotoxicity in either human liver cell line and primary hepatocytes.

The in-depth comparison of all studies above suggested caffeine has an effect in the contribution of gene mutation in microorganisms, while intake of caffeinated coffee expresses an opposite effect in the protection of gene in human.

Taking all together, caffeinated and decaffeinated coffee may be considered a functional beverage for protection of our body cells against alternation of DNA transcription in the initiation of cancers.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

Sources
(1) Potential genotoxic, mutagenic and antimutagenic effects of coffee: a review by Nehlig A1, Debry G.(PubMed)
(2) Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee? by Wu X1, Skog K, Jägerstad M.(PubMed)
(3) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)

Friday, 5 October 2018

Coffee, The Potent Functional Beverage Which Blocks the Onset of Metabolic Syndrome, Studies Found

By Kyle J. Norton, Master of Nutrition

Coffee consumed daily and regularly may have a substantial and potential effect in blocking the inset of metabolic syndrome, some scientists suggested.

Metabolic Syndrome is a group of risk factors associated with the development of cardiovascular disease and type 2 diabetes, including high blood pressure, abnormally high blood cholesterol and triglyceride levels,.....

According to the statistic, about a quarter of the US population have metabolic syndrome and the numbers are increased at an alarming rate.

The Western diet with a high on saturated and trans, refine sugar, and salt and processed foods, is associated with the early onset of the condition.

Dr. Christos Pitsavos, in the evaluation of the effect of diet in the risk metabolic syndrome, wrote, "People with the metabolic syndrome may benefit from intensive lifestyle modifications including dietary changes and adopting a physically more active lifestyle".

These statements suggested that everyone can prevent the development of the syndrome through modification their daily diet accompanied by a change to a healthy lifestyle.

The doctor continued, " During the last decades increasing scientific evidence has emerged that protective health effects can be obtained from diets that are rich in fruits, vegetables, legumes, and whole grains, and which include fish, nuts, and low-fat dairy products. Such diets need not be restricted in total fat intake as long as energy intake does not exceed caloric expenditure and if they emphasize predominantly vegetable oils that have a low content of saturated fats and partially hydrogenated oils".

Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the searching of database of PubMed and the China National Knowledge Infrastructure (CNKI) for relevant articles published between 1 January 1999 and 31 May 2015, including 11 published reports and 13 studies with a total of 159,805 participants eligible for our meta-analysis, the relative odd risk ratio of metabolic syndrome between the highest vs lowest category of coffee consumption was 0.872

The review also observed a nonlinear relationship between coffee and coffee caffeine consumption in the amelioration of risk of metabolic syndrome, by dose-response analysis.

Additionally, in a cross-sectional population-based survey of 8,821 adults (51.4% female) conducted in Krakow, Poland. to evaluate the coffee and tea consumption and risk of metabolic syndrome, using food frequency questionnaires, researchers after the observation of the questionnaire returned from participants expressed that there is an interesting association between high coffee consumption of 3 cups and the clusters of lower BMI, waist circumference, systolic and diastolic blood pressure, triglycerides, and higher HDL cholesterol compared to those drinking less than 1 cup/day.

The study apparently indicated that people drinking 3 cups of coffee daily and regularly have a favorably ameliorated risk of metabolic syndrome even after adjusting for potential confounding factors.

More importantly, the study also pointed out that high coffee consumption was negatively associated with waist circumference, hypertension, and triglycerides in women but not in men.

Furthermore, in animal evaluation of the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats including Diabetic Zucker rats with metabolic syndrome and control Zucker rats, researchers at the Fluminense Federal Institute showed that animals received daily doses of coffee by gavage for 30 days express a substantially decreased risk of metabolic syndrome by reducing serum glucose, total cholesterol, and triglycerides, compared to non treatment group.

Dr. Abrahão SA, the lead researchers said, "The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2".

The findings from the above studies suggested that coffee drinking daily and regularly have a favorably profound effect in decreasing the risk of metabolic syndrome, particularly in women.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Coffee consumption and risk of the metabolic syndrome: A meta-analysis by Shang F1, Li X1, Jiang X2.(PubMed)
(2) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)
(3) Diet, Exercise and the Metabolic Syndrome by Christos Pitsavos, Christos Pitsavos, Demosthenes Panagiotakos,, Michael Weinem, and Christodoulos Stefanadis. (PMC)

Yoga, The Integrate Form of Exercise In the Prevention and Treatment of Maternal Anxiety

Yoga may be used as a potential treatment in reduced anxiety in maternal women, a study by the Centre Hospitalier Universitaire de Québec suggested.

Maternal anxiety is a condition which appears during pregnancy characterized by a state of excessive uneasiness and apprehension, typically with compulsive behavior or panic attacks.

Some researchers suggested that anxiety may be attributed to the overreaction of the sympathetic nervous system that has a function to prepare our body for emergency and the conscious or even unconscious mind in cases of a need for defense.

The reaction sympathetic nervous system causes overproduction of certain hormones which in turn, induce the imbalance of the stress hormones in the body such as adrenaline and cortisol, and the precursor hormone DHEA, affecting a person psychological wellbeing in the initiation of anxiety.

Researchers do not know why some people are susceptible to the risk of anxiety, while others do not. However, they do know certain factors such as gene inherited from the parents, family history, gender and people with stressful and traumatic life experiences and people who are drugs abusers are associated with increased risk of anxiety.

Most symptoms of maternal anxiety include feeling unable to cope. very alone and frightened. depressed. disconnected from self and/or the baby. anxious about the baby. and seeing everything as stressful. particularly a feeling of not able to “let go” and relax.

In some women, irreparable effects of anxiety during pregnancy can change pregnancy into an unpleasant event of women’s life, affecting some serious effects in the offspring’s health.

Yoga, the ancient technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture.....

The technique has been well known for people in the Western world and some parts in Asia, due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the review of literature posted in Cochrane Pregnancy and Childbirth Group's Trials Register (30 November 2010), MEDLINE (1950 to 30 November 2010), EMBASE (1974 to 30 November 2010), the National Center for Complementary and Alternative Medicine (NCCAM) (1 December 2010), ClinicalTrials.gov (December 2010) and Current Controlled Trials (1 December 2010) involving pregnant women of any age at any time from conception to one month after birth, researchers found that

* In compared with usual care, yoga and other techniques with mind-body interventions in one study with 133 women expressed a positive effect on anxiety during labor decreasing anxiety at the early and middle stages of labor.

* Another study also suggested that yoga and other techniques with mind-body interventions had a positive effect on anxiety and depression in the immediate postpartum period

Dr. Marc I, the lead author said, "Mind-body interventions might benefit women's anxiety during pregnancy" and " there is some but no strong evidence for the effectiveness of mind-body interventions for the management of anxiety during pregnancy".

Even with these favorable outcomes, researchers in the review still concern of the small number of studies per intervention and to the diversity of outcome measurements with no meta-analysis.

Other, also in the review of literature from in four major electronic databases: CINAHL, PubMed, PsycINFO, and EMBASE using Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines with 13 publications met inclusion criteria and selected. researchers indicated that most studies expressed a generally effective in reducing anxiety in pregnant women participated in yoga class.

Not only that, Dr. Sheffield KM, the lead author said, " The use of yoga in the perinatal period shows promise in improving mental health and well-being for women and infants".

Truly, yoga meditation and mindfulness only calm the nervous system in the modulation of hormones production without inducing overexpression of certain hormones which may cause anxiety but also
bring the prenatal mother back to the present and deal the situation in a thoughtful way.

These results may restore the feeling of joy, connection with the baby, the happiness that the baby will bring, the pleasure to have a baby and a feeling of comfort in the belly that carries the baby, etc.

In support of the above analysis, a joint study conducted by the University of Manchester in 59 primiparous, low-risk pregnant women completed questionnaires assessing state (State-Trait Anxiety Inventory; STAI-State), trait (STAI-Trait), and pregnancy-specific anxiety (Wijma Delivery Expectancy Questionnaire; WDEQ) and depression (Edinburgh Postnatal Depression Scale; EPDS) before randomization (baseline) to either an 8-week course of antenatal yoga or treatment-as-usual (TAU); both groups repeated the questionnaires at follow-up, showed that
* Compared to the control group, yoga participated group in one single class showed to reduce both subjective and physiological measures of state anxiety (STAI-S and cortisol), and

* This single class-induced reduction remained through the final session of the intervention

* Yoga group also improved the reduction in WDEQ score

After adjusting to other risk factors, researchers said, " Antenatal yoga seems to be useful for reducing women's anxieties toward childbirth and preventing increases in depressive symptomatology".

Taking all together, there is no doubt that yoga may be considered a potential and therapeutic treatment in reducing risk and symptoms and treatment of anxiety maternally.

Sources
(1) Mind-body interventions during pregnancy for preventing or treating women's anxiety byMarc I1, Toureche N, Ernst E, Hodnett ED, Blanchet C, Dodin S, Njoya MM. (PubMed)
(2) Efficacy, Feasibility, and Acceptability of Perinatal Yoga on Women's Mental Health and Well-Being: A Systematic Literature Review by Sheffield KM1, Woods-Giscombé CL2.(PubMed)
(3) Effects of antenatal yoga on maternal anxiety and depression: a randomized controlled trial by Newham JJ1, Wittkowski A, Hurley J, Aplin JD, Westwood M.(PubMed)

Herbal Arnica, The Functional Herb Which Stops the Onset of Chronic Diseases Associated with Oxidative Stress, Researchers Found

Arnica may have a profound and therapeutic effect in reducing the risk of diseases associated with overexpression oxidative stress, some scientist suggested.

The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Dr. Ercal N, the lead author in the study of the relation of toxic metals and oxidative stress, wrote, "antioxidants may play an important role in abating some hazards of heavy metals. In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress".

There is no single cause of oxidative stress. Some researchers suggested that numbers of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

By changing diet and lifestyle, oxidative stress can be managed or avoided, Dr. Seungyoun Jung, the lead author in the study of Healthy Dietary Patterns and Oxidative Stress suggested, "Healthy diets may lower oxidative stress and risk of chronic diseases" and "Among specific food groups that contribute to these diet scores, significantly positive associations were observed with legumes and vegetables for FlOP_360, vegetables and fruits for FlOP_320, and legumes and alcohol for FlOP_400".

Where fluorescent oxidation products (FlOP) is a global marker of oxidative stress

Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The Herbal medicine used in herbal medicine for centuries to treat strains, sprains, and bruises.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the analysis of the effect of Arnica Arnica on mitochondrial oxidative stress induced by Ca(2+) plus inorganic phosphate and/or Fe(2+)-citrate-mediated lipid peroxidation through changes in oxygen consumption rates in adult male Wistar rat, researchers found that application of Arnica at dose of 6cH, 12cH, 30cH or succussed 30% ethanol (control) for 21 days, exert a strong activity in reduced expression of lipid peroxidation of mitochondrial membranes through inhibiting the antimycin-A, a toxic chemical with function in initiated production of free radicals.

Under oxidative stress conditions caused by injection of Ca(2+) and inorganic phosphate, tested group with a dose of Arnica 30cH demonstrated the effect in decreasing mitochondrial O(2), an indication of lesser expression of free radicals presented in the mitochondrion, through the herbal antioxidant activity.

In liver tissues, administration of Anise at dose 30cH in the tested group also protected the hepatic mitochondrial membrane permeabilization by inhibited ROS on the induction of lipid peroxidation and precipitated fragmentation of proteins.

Further evaluation of the study showed that these results of free radical inhibitory effect were attributed to levels of antioxidant from the herb and the herb in the stimulated production of antioxidants of the tested host.

Additionally, in the investigate the therapeutic effects and mechanism of action of A. Montana flower methanol extract (AMME) against both inflammation and oxidative stress in a collagen-induced arthritis (CIA) rat model, scientists suggested that oral administration of AMME reduces clinical signs and improves the histological and radiological status of the hind limb joints, through reducing overexpression of levels of nitric oxide, tumor necrosis factor-α, interleukins (IL-1β, IL-6 and IL-12) and titer of anti-type II collagen antibody activated by high levels of oxidative stress.

This inhibitory effect of AMME against overproduction inflammatory factors not only reverses the disturbed antioxidant levels and peroxidative damage but also inhibits the overproduction of inflammatory cytokines in facilitated cell damage and healthy cell death at the site of infection.

Moreover, according to the gas chromatography/mass spectrometry (GC/MS) analysis, the function of Arnica in the alleviation of arthritis by ameliorating ROS expression was attributed to the combined action of phenolic and flavonoid compounds.

Dr. Sharma S, the lead author said, " The study also shed some light on mechanisms involved in the diminution of inflammatory mediators and free radical-generating toxicants and enhancement of the antioxidant armory, thereby preventing further tissue damage, injury and synovial hyperproliferation in arthritis".

The above differentiation was supported by the National Institute of Research and Development for Biological Sciences study of A. montana and A. absinthium ethanolic extracts antioxidant activity and protective effect against H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.

According to the final assessment, researchers suggested that both A. absinthium and A. montana extract showed a strong antioxidant capacity but lesser in A. montana, compared to A. absinthium.

At the doses of the range of 10-100 mg/L and A. montana and 10-500 mg/L A. absinthium, both extracts exhibited a significant oxygen radical absorbance capacity and 2,2-diphenyl-1-picrylhydrazyl free radical-scavenging activity and protected fibroblast cells against hydrogen peroxide-induced oxidative damage, depending on the levels of flavonoids and phenolic acids contents presented in the extracts.

According to the neutral red and lactate dehydrogenase assays, pretreatment with 10 mg/L A. montana and 10-300 mg/L A. absinthium was considered the best protection against the early onset of ROS production in H2O2-induced oxidative stress in a mouse fibroblast-like NCTC cell line.

Importantly, pre-treatment with A. montana and A. absinthium extracts also restored the proportion of cells in each phase of the cell cycle through inhibiting oxidative stress in the induction of cytotoxicity.

Taken together, Arnica and its bioactive chemical may be considered a functional food in reduced inflammatory-related diseases caused by overexpression of oxidative stress. However, intake of Arnica supplement should be taken with extreme care for the prevention of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress by de Camargo RA1, da Costa ED, Catisti R.(PubMed)
(2) Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress by Sharma S1, Arif M1, Nirala RK1, Gupta R2, Thakur SC(PubMed)
(3) Evaluation of antioxidant and cytoprotective activities of Arnica montana L. and Artemisia absinthium L. ethanolic extracts by Craciunescu O1, Constantin D, Gaspar A, Toma L, Utoiu E, Moldovan L.(PubMed)
(4) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage by Ercal N1, Gurer-Orhan H, Aykin-Burns N.(PubMed)
(5) Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study by Seungyoun Jung,1,2,3,* Stephanie A. Smith-Warner,1,2 Walter C. Willett,1,2,4 Molin Wang,2Tianying Wu,5 Majken Jensen,2,4 Susan E. Hankinson,4,6 and A. Heather Eliassen. (PMC)

Yoga Therapy In the Prevention and Treatment of Chronic Inflammatory Diseases

By Kyle J. Norton (Master of Nutrients, All right reserved)

Yoga therapy may have a strong impact in reducing the risk of inflammation by significantly decreased expression of pro-inflammatory cytokines, a US university study suggested.

Inflammation is a natural response of the immune system in the stimulation of the production of inflammatory cytokines with an aim to protect our body against infectious agents in the acute phase of bodily injury and tissue damage.

However, in many instances, overexpression of pro-inflammatory cytokines can cause cells death and tissue damage, leading to irreversible organs damage with large scars formation.

For example, overexpression of pro-inflammatory cytokines in the healing of hepatitis virus infection can lead to liver scars.

Furthermore, inflammation that lasts more than 3 months may be considered chronic inflammation, a leading cause of chronic diseases.

Chronic inflammation occurs when the immune system no longer has the ability to kill off all the infectious agents, during the onset of acute infection.

Moreover, chronic inflammation also happens in people with the autoimmune disorder. In this case, the immune system attacks the bodily normal healthy tissue, by mistaking them for foreign pathogens that cause disease.

Yoga, the ancient technique for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture.....

The practice has been well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a randomized controlled 3-month trial conducted with two post-treatment assessments of 200 breast cancer survivors assigned to either 12 weeks of 90-minute twice per week hatha yoga classes or a wait-list control researchers at The Ohio State University showed that
* Yoga demonstrated significantly reduced proteins in the production of pro-inflammatory expression, namely IL-6, TNF-α, and IL-1β in compared to the control group.

* Inflammation induced lower levels of energy also reduced such as fatigue and improved vitality after 3 months of engagement but not at the beginning of the class.

Dr. Kiecolt-Glaser JK, the led author said, "Chronic inflammation may fuel declines in physical function leading to frailty and disability. If yoga dampens or limits both fatigue and inflammation".

Truly, yoga practice calms the central nervous system against the onset of psychological stress which in turn, decrease the production of stress hormones in compromising the immune system.

Yoga practice has a direct impact on the calming of the nervous system in turn, improves the immune system in the correct differentiation of its response against foreign pathogens. thus, reducing the risk of autoimmune disease and overproduction of inflammatory cytokines in initiating chronic inflammatory diseases.

Other researchers in the concerns of global obesity prevalence and overexpression of tissue and circulating inflammatory biomolecules in these group of the population may cause vascular inflammation and atherogenesis, and subsequently, cardiovascular disease developing postulated that yoga-based lifestyle intervention may be used as a promising option,
* In reducing the weight of obesity that decreases the risk of onset of inflammatory diseases.

* In reducing the risk of chronic diseases as inflammation may be prevented and managed through a change of lifestyle

The study also emphasized that yoga therapy is simple to follow and cost-effective with high compliance. therefore, it may be recommended as a secondary treatment combined with the standard application.

Furthermore, Dr. Sarvottam K, the led author said, "The efficacy of such lifestyle intervention programmes is multifaceted and is achieved via a reduction in weight, obesity-related inflammation on and stress, thereby culminating into risk reduction towards several chronic diseases including CVD".

By bringing back the presence and dealing it in a positive way, long-term yoga participants may choose to improve immune function through the change of diet and lifestyle to combat chronic inflammatory diseases.

More interestingly, in a proposed study of 16 breast cancer survivors with persistent cancer-related fatigue randomized to a 12-week Iyengar yoga intervention (n=16) or a 12-week health education control condition (n=15), researchers indicated that
* Yoga treatment group expressed a reduced production of pro-inflammatory transcription including, nuclear factor kappa B (NF-κB), and increased activity of the anti-inflammatory cytokines such as glucocorticoid receptor.... compared to control.

* All inflammatory markers, such as soluble tumor necrosis factor receptor type II (sTNF-RII) were lower in yoga therapy group compared to the increase in the educational group.

Dr. Bower JE the led author opinionated, Yoga participated improved the lower level of energy caused by inflammation-related gene expression in breast cancer survivors with persistent probably through enhancing behavioral and physical health after 12 weeks.

Taking all together, Yoga may be considered as an integrated form of exercise in reduced risk and treatment of inflammation-inducing poor behavioral and physical activities.

Sources
(1) Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial by Kiecolt-Glaser JK1, Bennett JM, Andridge R, Peng J, Shapiro CL, Malarkey WB, Emery CF, Layman R, Mrozek EE, Glaser R.(PubMed)
(2) Obesity-related inflammation & cardiovascular disease: efficacy of a yoga-based lifestyle intervention by Sarvottam K, Yadav RK1.(PubMed)
(3) Yoga reduces inflammatory signaling in fatigued breast cancer survivors: a randomized controlled trial by Bower JE1, Greendale G2, Crosswell AD3, Garet D4, Sternlieb B5, Ganz PA6, Irwin MR7, Olmstead R8, Arevalo J9, Cole SW10. (PubMed)

Green Tea and Its' Polyphenols (GTPs) That Protect Our Bodily Skin Against the Onset of Cancer, Scientists Say

By Kyle J. Norton, Master of Nutrition

Green tea may have a strong and positive effect in reduced risk and treatment of skin cancer, some scientists suggested.

Skin cancer is a medical condition characterized by irregular cell growth in the issues of skin.

At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, approximately, 87,110 new cases of invasive melanoma are diagnosed in the U.S every year.

The exact causes of skin cancer are unknown. Researchers believed that there are a set of factors that can have the substantial effect to initiate the onset of skin cancer.

Truly, according to the studies, people who have fair skin, regardless of skin color, a history of sunburns, excessive sun exposure, including occupations which are required to work outside during Summar months, moles, family history of skin cancer. and previous and personal history of skin cancer is at the increased risk of skin cancer or recurrence of skin cancer.

The American Institute for Cancer Research, certain lifestyle habits can increase the risk of skin cancer, such as drinking too much coffee, excessive alcohol drinking and long-term intake of certain medications in suppressing the immune system.

Green tea a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.

The evaluation of green tea effect in overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) which has been found to increase risk of the development of melanoma and non-melanoma skin cancers in mice model showed that oral administration of green tea polyphenols (GTPs) in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in tested subjects.

Particularly, (-)-Epigallocatechin-3-gallate (EGCG), the major and most photoprotective polyphenolic component of green tea also exhibited a protective activity against UV in induction of skin cancer, through induction of immunoregulatory cytokine interleukin (IL) 12 in differentiation of naive T cells into Th1 cells and acted as T cell-stimulating factor in stimulate the growth and function of T cells.

Moreover, interleukin (IL) 12 also demonstrated a significant effect as an antagonist against immunosuppression induced by solar/ultraviolet (UV) radiation by restoring immune responses and also stimulating DNA repair.

Further analysis also indicated that green tea (-)-Epigallocatechin-3-gallate (EGCG) also inhibited UV in the induction of skin tumors; the angiogenetic effect in the stimulated production of new blood vessels to
provide nutrients and oxygen for cancer cells proliferation and survivals and initiated cytotoxic T lymphocyte cells in induced cancer and infectious and damage cells apoptosis.

Interestingly, additional study of green tea polyphenols (GTPs) in prevention of UVB irradiated (80 mJ/cm(2)) 3 times each week for 24 wk in induced skin cancer in mice divided in to group consumed water and group fed with water containing 2 g/L GTPs, showed that group treated with GTPs displayed a significantly reduced UVB-induced tumor incidence by 35%, tumor multiplicity by 63%, and tumor growth by 55% in compared to non treatment group.

Group treated with GTPs+UVB also demonstrated a reduced expression of the matrix metalloproteinases (MMP)-2 and MMP-9, which are activator associated with progression from benign to advanced cancer and enhanced expression of specific endogenous tissue inhibitors of metalloproteinases (TIMPs), tissues inhibitor of MMP in skin tumors in compared to mice treated with UVB alone.

Furthermore, GTPs+UVB group also reduced expressions of CD31 and vascular endothelial growth factor, inactivated development of new blood vessel to nourish skin tumor cells proliferation and site expansion and inhibited expression of proliferating cell nuclear antigen, a key factor in DNA replication and cell cycle regulation in skin cancer in compared to UVB group.

More importantly, mice treated with GTPs+UVB group also showed more cytotoxic CD8(+) T cells in the tumors in compared to UVB group by exhibited greater activation of caspase-3 expression in induced apoptosis of the tumor cells.

The information findings suggested a potential and therapeutic effect of green tea and its bioactive polyphenols (GTPs) in attenuated risk, progression, and treatment of melanoma and non-melanoma skin cancers.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Prevents Skin Cancer by Two Mechanisms by Navid Bouzari, Yvonne Romagosa, Robert S. Kirsner(PubMed)
(2) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK. (PubMed)
(3) Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors by Mantena SK1, Meeran SM, Elmets CA, Katiyar SK. (PubMed)