8 Delicious Vegetables That Kill Breast Cancer Cells in Vivo and Vitro, Researchers Suggest

Kyle J. Norton

The prevalence of breast cancer has been acknowledged in the scientific community worldwide.

Breast cancer widespread in women in Southeast Asian as a result of over 2 decades of economic prosperity caused by unhealthy diet is a major concern.

The findings for effective treatments are ongoing with some successes, but the discovery of effective ingredients for the prevention and treatment of breast cancer with little or no side effects have proven difficult.

According to statistic, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Detection of tumorigenesis through self-observation is still the best approach to discover breast cancer in an early stage.

According to the statistic provided by the American Breast Cancer Foundation, The 5 years and 10 years survival rate of breast cancer detected in the early stage is 100%.

But the reduction of the mortality at the late stage of breast cancer diagnosed has not been accounted, even with extensively modern technology in the field of diagnosis and insurance protection in the Western world.

Truly, The American Cancer Society (ACS) statistic states in women diagnosis at the late stage, "the five-year survival rate after diagnosis for people with stage 4 breast cancer is 22, percent. This percentage is considerably lower than at earlier stages".

Some scientists suggested that healthy diet with plenty vegetables and fruits(1)(2)(3) accompanied with the change of lifestyle(4)(5)(6) may be the only choice for women to reduce the risk of the disease.

In fact, certain vegetables(7)(8), fruits(9)(10) and bioactive phytochemicals found in foods(23)(24) and herbs(33)(34) have been found to induce apoptosis and anti-proliferation of breast cancer cells by blocking the energy sources to the tumor site and suppressing the promoted cancers genes.

1. Cruciferous vegetables
Cruciferous vegetables are the group of vegetable belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.

Isothiocyanate (ITC), one of the major chemical constituent found in cruciferous vegetables has been studied extensively over the past three decades against breast cancer in pre-clinical models.

Benzyl isothiocyanate, the derivative of isothiocyanate displayed an significant efficacy in inhibited carcinogen metabolism and signaling pathways relevant to tumor progression and invasion(11) against MDA-MB-231(breast cancer cell line), human breast cancer xenografts(mutation tissues)(12) by suppressing X-linked inhibitor of apoptosis (XIAP) protein expression of cancer cell line MCF-7 and reduced levels of mutations of p53(antigens) protein level(13).

Loss of normal function of p53 gene was associated with over 50% of cancer patients and mutation p53 gene may have an oncogenic potential.

P53, is a protein that regulates the cell cycle and functions of tumor suppression.
In Her-2 positive (a most aggressive case of breast cancer), indole-3-carbinol, a naturally occurring compound found in cruciferous vegetables, used combination with paclitaxel (a mitotic inhibitor) synergistically inhibited growth of Her2/neu human breast cancer cells by cancer cells cycle arrest in the G2(pre-mitotic phase) and M(nuclear division) phase and induced apoptosis/necrosis(14).

I3C used alone also inhibited Her-2breast cancer cell growth in a dose-dependent manner through increasing production of Bax(an apoptosis promoter) and decreasing expression of Bcl-2(an apoptosis inhibitor) and, thereby, increasing the ratio of Bax to Bcl-2 in favoring apoptosis(15).

2. Tomatoes
Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America.

Because of its health benefits, the tomato is grown worldwide for commercial purpose and often in the greenhouse.

Lycopene, a major carotenoid component of tomato has been known in the research community with the property to attenuate the risk of breast cancer.

In a time and doses dependent, the compound showed an anti-proliferative activity against ER(estrogen receptor)/PR(progesterone receptor) positive MCF-7, HER2-positive SK-BR-3 and triple-negative MDA-MB-468 cell lines by arresting cell cycle at the G0 /G1phase(interphase together - chromosomes replicate in preparation for cell division) at physiologically achievable concentrations(range) found in human plasma(16)

Lycopene also Inhibited the ER-positive MCF-7 through cell cycle progression, ER-negative MDA-MB-231 cells through G1 phase cell cycle-arrest(17).

Application of lycopene not only restored the GSTP1 expression but also at 2 microM, once per week for 2 weeks induced demethylation of RARbeta2 (tumor suppressor gene) and the HIN-1(a cell growth inhibitor)) genes in the noncancer MCF10A fibrocystic breast cells(18).

3. Figs
N-hexane insoluble fraction (HIF) found in figs may be lesser known for its efficacy in breast cancer cell suppressive activity.

The combination of HIF and doxorubicin exerted a greater inhibition on cell growth in (Human ductal breast epithelial tumor cell line) T47D cells and increased the incidence of cells undergoing apoptosis, compared to doxorubicin alone(19).

The soluble fraction (Ethyl acetate soluble fraction (EASF)) in fig leave was also found to enhance the cytotoxic effect of doxorubicin by changing the inhibition of cell cycle G(2)/M to G(1) phase(20).

And Acetone extract of Ficus religosa leaf (FAE) demonstrated an irreversible inhibition of breast cancer cell growth with moderate toxicity by stimulating the loss of mitochondrial membrane potential in multiple breast cancer cell lines and accelerated cell death through the photosensitizing effect(21).

4. Garlic
Garlic is a natural superfood with antibiotic antiviral, antifungal, anticoagulant, and antiseptic properties.

Diallyl trisulfide(DAS), a derived organosulfur compounds (OSCs) suppressed the a ratio of viable cells in the culture of (Human breast cancer cell line) MCF-7 and MCF-12a (a non-tumorigenic epithelial cell line) by decreasing the percent of cancer cells in phase G(2)/M and induced apoptotic cell death through stimulated function of Bax protein and p53(cellular tumor antigen) protein expression(22).

Application of DAS also enhanced the effect of eicosapentaenoic acid, a breast cancer suppressor, and decreased the effect of linoleic acid, a breast cancer enhancer and reduced the side effects caused by anti-cancer agents(23).

The protein fraction from garlic was effective in inhibiting tumor growth more efficiently than garlic extract in enhancing the CD8(+) T-cell infiltration into the tumor site(24).

5. Spinach
Spinach, an edible flowering plant in the genus Spinacia, belongings to the family of Amaranthaceae, is considered a healthy plant, containing various vitamins and minerals, native to central and southwestern Asia.

Consuming spinach was found to exhibit a significantly protective effect on breast cancer among premenopausal women(25).

Eating carrots or spinach more than twice weekly, compared with no intake, was associated with an odds ratio of 0.56 but did not distinguish among several potential explanations for the protective association, observed between intake of carrots and spinach and risk of breast cancer(26).

It is said that included supplementation of A. gangeticus aqueous extract of red spinach at 10% reduced progression of in breast cancer in the rat model(27).

6. Kelp
Kelps are large seaweeds (algae) growth under shallow in underwater of oceans belongings to the class Phaeophyceae in the order Laminariales, used for food in many cultures.

Laminaria, a brown kelp seaweed containing the antibiotic substance, 1-3 beta glucan, was effective inactivated host-mediated immune response in prevented the initiation of breast cancer(28).

Japanese seaweed (Laminaria angustata) extracts were also found to exert its antimutagenic effects in certain breast and colon carcinogen(29).

L-tryptophana substances isolated from the kelp rhizoid, may play an important role in the inhibition of breast cell proliferation(30)(31).

7. Chili pepper
Chili pepper is the fruit of the plant from the genus Capsicum, belongings to the nightshade family, Solanaceae, used in human history for spices and cultivated for commercial profits.

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a chemical constituent of chili peppers used in many cultures as anticancer agent, inhibited the growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, reduced 50% the size of MDA-MB231 breast cancer tumors(32), through inducing cellular apoptosis via a caspase-independent pathway in MCF-7 cells(33).

In the comparison of Dohevanil, researchers found that both vanilloids, precursor of capsaicin and dohevanil inhibited the growth of DNA fragmentation in MCF-7 cells(34).

8. Carrot
Carrot is root vegetable with orange color normally, a sub spice of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Intake of cruciferous vegetable and carrot are inversely associations with risk of estrogen receptor-negative/progesterone receptor-negative breast cancer(35).

Wild carrot or Daucus carota L. ssp. carota (Apiacea) oil extract, used in traditional medicine in Lebanon and different regions throughout the world, was found to inhibit human colon (HT-29, Caco-2) and breast (MCF-7, MDA-MB-231) cancer cell lines, through apoptotic and antiproliferative activities(36).

The information findings once again emphasized the importance of a healthy diet with plenty of vegetables and fruits and change of lifestyle in breast cancer risk.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Life style and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC. (PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA. (PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME. (PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice. by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(11) Benzyl isothiocyanate: double trouble for breast cancer cells by Rao CV. (PubMed)
(12) Inhibition of human breast cancer xenograft growth by cruciferousvegetable constituent benzyl isothiocyanate by Warin R, Xiao D, Arlotti JA, Bommareddy A, Singh SV. (PubMed)
(13) p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression by Kim SH, Singh SV. (PubMed)
(14) 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells by McGuire KP, Ngoubilly N, Neavyn M, Lanza-Jacoby S.(PubMed)
(15) Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells by Rahman KM, Aranha O, Glazyrin A, Chinni SR, Sarkar FH.(PubMed)
(16) Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines by Takeshima M, Ono M, Higuchi T, Chen C, Hara T, Nakano S.(PubMed)
(17) [Effect of lycopene on the proliferation of MCF-7 and MDA-MB-231 cells].
[Article in Chinese] by Wang AH, Zhang LS. (PubMed)
(18) Modulation of gene methylation by genistein or lycopene in breast cancer cells, by King-Batoon A, Leszczynska JM, Klein CB. (PubMed)
(19) Combinational effects of hexane insoluble fraction of Ficus septica Burm. F. and doxorubicin chemotherapy on T47D breast cancer cells by Nugroho AE, Hermawan A, Putri DD, Novika A, Meiyanto E, Kawaichi M.(PubMed)(20) Synergistic effects of ethyl acetate fraction of Ficus septica Burm. f. and doxorubicin chemotherapy on T47D human breast cancer cell line by Nugroho AE, Hermawan A, Putri D P, Meiyanto E, Hakim L.(PubMed)
(21) Bax translocation mediated mitochondrial apoptosis and caspase-dependent photosensitizing effect of Ficus religiosa on cancer cells by Haneef J, Parvathy M, Thankayyan R SK, Sithul H, Sreeharshan S.(PubMed)
(22) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A, El-Saadani M, Sultan AS.(PubMed)
(23) Anticancer effects of garlic and garlic-derived compounds for breast cancer control.
Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K.(PubMed)(24) Purified Protein Fraction of Garlic Extract Modulates Cellular Immune Response against Breast Transplanted Tumors in BALB/c Mice Model by Ebrahimi M, Mohammad Hassan Z, Mostafaie A, Zare Mehrjardi N, Ghazanfari T.(PubMed)
(25) Food sources of phytoestrogens and breast cancer risk in Mexican women by Torres-Sánchez L, López-Carrillo L, López-Cervantes M, Rueda-Neria C, Wolff MS.(PubMed)
(26) Intake of carrots, spinach, and supplements containing vitamin A in relation to risk of breast cancer by Longnecker MP, Newcomb PA, Mittendorf R, Greenberg ER, Willett WC(PubMed)
(27) Potential anticancer effect of red spinach (Amaranthus gangeticus) extract by Sani HA, Rahmat A, Ismail M, Rosli R, Endrini S.(PubMed)
(28) The dietary intake of Laminaria, a brown seaweed, and breast cancer prevention by Teas J.(PubMed)
(29) Effect of Japanese seaweed (Laminaria angustata) extracts on the mutagenicity of 7,12-dimethylbenz[a]anthracene, a breast carcinogen, and of 3,2'-dimethyl-4-aminobiphenyl, a colon and breast carcinogen by Reddy BS, Sharma C, Mathews L.(PubMed)
(30) Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells.
Travers MT, Gow IF, Barber MC, Thomson J, Shennan DB. (PubMed)
(31) [Substance isolated from the kelp rhizoid identified as L-tryptophan shows high inhibition of breast cancer].[Article in Japanese] by Takahashi N, Ojika M, Dogasaki C, Nishizawa M, Fukuoka H, Sahara H, Sato N, Mori M, Kikuchi K.(PubMed)
(32) Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway by Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP. (PubMed)
(33) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway by Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR.(PubMed)
(34) Apoptosis induction by dohevanil, a DHA substitutive analog of capsaicin, in MCF-7 cells by Tuoya, Baba N, Shimoishi Y, Murata Y, Tada M, Koseki M, Takahata K.(PubMed)
(35) Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health Study. by Boggs DA, Palmer JR, Wise LA, Spiegelman D, Stampfer MJ, Adams-Campbell LL, Rosenberg L.(PubMed)
(36) The antioxidant and anticancer effects of wild carrot oil extract by Shebaby WN, El-Sibai M, Smith KB, Karam MC, Mroueh M, Daher CF. (PubMed)

Eggplant, The Night Shape Veggie Which Blocks Melanoma Cells From Spreading, in Vivo and Vitro, Scientists Show

By Kyle J. Norton, Master of Nutrition


Eggplant may have a potential and substantial effect in reducing risk and treating melanoma, some scientists suggested.

Melanoma is a type of skin cancer characterized by irregular cell growth in the pigment-containing cell.

At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

the exact causes of Melanoma are unknown. However, some researchers suggested that it is likely caused by a combination of factors.

Truly, certain risk factors, such as environmental and genetic factors, exposure to ultraviolet (UV) radiation from the sun are associated with increased risk of the disease.

According to statistic, approximately 87,110 new cases of invasive melanoma were diagnosed in the U.S. in 2017.

The American Cancer association single out mutation of tumor suppressor genes such as CDKN2A and CDK4 that preventing them from doing their normal job of controlling cell growth is one of the major causes of melanoma.

If you experience some of the symptoms of sores that do not heal. Pigment, spreading redness or swelling, persistent itchiness, tenderness or pain,.... and bleeding from an existing mole. Please check with your doctor to rule out the possibility.

The 5 years survival rate of early diagnosis of Melanoma is about 97% and The 10-year survival is around 95%.

Eggplant is a species of S. melongena with deep purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

In the evaluation of the effect of glycoalkaloids, the nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants in numbers of cancer cell lines, researchers showed that the isolated phytochemicals express a significant effect of inhibition of the process of the early stage of various types of cancer occurrence through inducing cancer cells apoptosis.

Further analysis, glycoalkaloids efficacy was attributed to the derived phytochemical compound solamargine inactivation of antioxidant activity against the formation of skin cancer through expression several biomarkers and signaling pathways.

In primary melanoma cell lines WM239 and WM115, application of solamargine with half inhibitory concentration IC50 demonstrated a profound effect of inhibited the growth of metastatic cancer cells and initiated apoptosis, through overexpression of lysosomal membrane permeabilization induced by leaky lysosomes during cell death, detected by lysosomalgalectin puncta assay, without causing damage to normal and benign skin cells, namely, WM35.


Observation of the cellular necrosis also indicated that solamargine's anti-skin cancer effect was confirmed by overexpression of cathepsin B which is considered as a biomarker of malignant lesions and various cancers by triggering extrinsic mitochondrial death pathway function in activated cellular apoptosis through the release of cytochrome c from mitochondria during the early stages of apoptosis and apoptotic tumor necrosis factor receptor-1(TNFR1).

Moreover, injection of the derivative solamargine also disrupted the intrinsic apoptosis pathway
through reduced expression of hILP/XIAP, an inhibitor of apoptotic cell death by blocking tumor cells proliferation.

Additional differentiation also suggested that the derivative solamargine also blocked the
expression of TNF receptor associated with tumors proliferation, survival, and differentiation to increase expression of proteins Bcl-xL, and Bcl2 that regulate anti-apoptosis, anti-cell cycle arrest.

Unlike other phytochemicals such as green tea EGCG inhibited apoptosis through both intrinsic and extrinsic apoptosis pathways, eggplant derivative solamargine selectively triggered melanoma cancer cells death through only death receptors.

After taking account of other confounders, Dr, Sana S. said, " Solamargine showed high efficacy in vitro particularly against the vertical growth phase (forming a true tumor) melanoma cells".

Taken together, eggplant with abundant glycoalkaloids may be considered as a functional food to ameliorated risk, progression, and treatment of melanoma. Intake of eggplant supplement should be taken with special care and only prescribed by experts.

However, additional data collection on large example size and multi-centers studies performed with human consumption of the eggplant whole food during the course of the disease will be necessary to complete the picture of the night shape veggie's anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1(PubMed)
(1) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber, and Sirin A. Adham(PMC)
(3) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway by Sana S. Al Sinani, Elsadig A Eltayeb, Brenda L. Coomber and Sirin A. Adham(Cancer cell international)
(4) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Brahma N. Singh,1 Sharmila Shankar,2 and Rakesh K. Srivastava*(PMC)

How to Boost Your Bone Health Beyond the Age of 50

Kyle J. Norton

Carrots may have a profound and positive effect of improving bone health, some scientists suggested.

Osteoporosis is a bone disease characterized by the inability of the body to produce bone to make up bone loss, leading the loss of bone density over a long period of time.

People with low bone density are susceptible to fracture, break from a fall due to bone weakening.

The exact causes of osteoporosis are unknown.  However, researchers do know that certain preventable risk factors such as smoking, low calcium intake, physical inactivity, excessive alcohol consumption and unpreventable risk factors such as aging, family history, genders, race, body frame size,... and sedentary works are associated to increase the onset of the disease.

Some researchers also suggested that loss of bone density due to age, medications used to treat breast cancer, arthritis, asthma and certain chronic diseases such as Crohn's disease and Addison's disease and hyperthyroidism, hypopituaritism and eating disorders are also considered as some major risk factors of osteoporosis.

According to the statistic provided by the National Osteoporosis Foundation, over 10 million Americans are affected by osteoporosis and 34 million more have low bone mass, called osteopenia.

Most common symptoms of osteoporosis include back pain, as a result of a fractured or collapsed vertebra, loss of height and a stooped posture.

Many patients with osteoporosis also experience symptoms of a bone fracture.

If you experience some of the symptoms of above, you may have osteoporosis.

Conventional medicine such as Bisphosphonates: Fosamax, Actonel, Boniva, Zoledronic Acid  Bisphosphonates may be effective on reduced risk of fracture, decelerated bone loss and ameliorate pain. However, they may induce some adverse effects, including impaired thinking, fainting, and feeling light-headed, rapid heart rate,.... and gastrointestinal discomforts.

If you are taking one of those medicines, please make sure you discuss the side effects with your doctor.

Carrot, a root vegetable with an orange color is a sub spice of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.


Nutrients
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C
13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium



In the reaffirm the antioxidant activity in protection of osteoporotic women, researchers at the University of Wisconsin (UW)-Madison launched an investigation of carotenoids in human serum effect of promotion of bone health among postmenopausal women.

In a total of 59 postmenopausal women participated, researchers found that
* Intake of carotenoids scores a significant effect of protecting the bone density, observed by the dual-energy x-ray absorptiometry and osteoporosis diagnosis was based upon T-scores.

* Serum lycopene and beta-cryptoxanthin measured by 0.03 and 0.006, respectively in participants were correlated to the total intake of fruits and vegetables.

* However, serum alpha-carotene concentration was strongly associated with carrot intake.

Researchers, after taking into account of other co and confounders suggested that carotenoids intake may have beneficial skeletal effects in women with osteoporosis.

Additionally, in vitro and in vivo studies suggest that carotenoids may have strong protective effect of inhibited bone resorption, according to researchers at the Jean Mayer USDA HNRCA at Tufts University in a differentiation of associations of total and individual carotenoid intake (alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein + zeaxanthin) with incident hip fracture and nonvertebral osteoporotic fracture.

Furthermore, in a total of 370 men and 576 women (mean age, 75 +/- 5 yr) from the Framingham Osteoporosis Study completed a food frequency questionnaire (FFQ) in 1988-1989 and followed for hip fracture until 2005 and nonvertebral fracture until 2003, researchers showed that

* Highest tertile of total carotenoid intake had a lower risk of hip fracture (p = 0.02).

* Higher lycopene intake had lower risk of hip fracture (p =0.01) and nonvertebral fracture (p = 0.02).

* However, total beta-carotene was associated with a weak protective trend for hip fracture alone and NO significant associations were observed with alpha-carotene, beta-cryptoxanthin, or lutein + zeaxanthin.

These results suggested that only lycopene was found to have a clinical effect on protection of bone health in all aspects in compared to other bioactive compounds isolated from carrot.

And several members in carotenoids may play a protective role in bone health in older adults.

Moreover, in the reassessed the carotenoids bone protective effect in inhibited bone resorption and stimulate proliferation and differentiation of osteoblasts, in 334 men and 540 women (mean +/- SD age: 75 +/- 5 y) in the Framingham Osteoporosis Study, researchers at the Tufts University showed that intake of lycopene may protect the mean of bone density in both genders
* Carotenoid and lycopene intake exerted a 4-y change in lumbar spine BMD for women, and

* Total carotenoids, beta-carotene, lycopene and lutein+zeaxanthin with 4-y change in trochanter BMD in men.

DR. Sahni S, the lead scientists said, "Carotenoids showed protective associations against 4-y loss in trochanter BMD in men and in the lumbar spine in women" and " These results support a protective role of carotenoids for BMD in older men and women".

Taken together, carrot and its bioactive compound lycopene may be considered as functional foods in reduced risk of osteoporosis, including inhibited bone resorption and proliferation and differentiation of osteoblasts,... in both older men and women.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis by Yang Z1, Zhang Z, Penniston KL, Binkley N, Tanumihardjo SA.(PubMed)
(2) Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study by Sahni S1, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL.(PubMed)
(3) Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study by Sahni S1, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL.(PubMed)

Herbal Cinnamon, The Kitchen Spice in Prevention and Treatment of Alzheimer's Diseases

By Kyle J. Norton, Master of Nutrition

Adding spicy cinnamon into your diet may have a significant effect of blocking the onset of Alzheimer's Diseases, a new study suggested.

 Although cinnamon is best known for its anti-diabetic effect, The spices also consist of certain chemical constituents associated to prevent insulin resistance(2).

The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).

Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life.

Alzheimer's gets worse over time, and it is fatal.

According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.

The exact causes of Alzheimer's disease are unknown. However, some researchers suggested that certain risk factors such as cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity) are associated to the onset of the disease(10).

Some researchers suggested that people who are following lifelong intake of Western diet and at higher risk due to family history should be aware of some early signs and symptoms such as memory loss, the difficulty of planning and solving problems, completing familiar tasks, determining time or place, finding the right words, misplacing items often. ... and difficulty making decisions.

If you experience some signs and symptoms above, please make sure to check with your doctor to rule out the possibility.

In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), researchers found that injection of cinnamon (CN) alleviates the increases of mRNA associated with Alzheimer's such as PTEN, Tau, and amyloid precursor protein, through its neuroprotective activity associated with improved whole-body insulin sensitivity and related changes in the brain.(4).

Cinnamon aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protecting tau from abnormal modifications, according to the University of California(5).

PTEN, is a tumor suppressor gene involved in the regulation of the cell cycle.

Tau protein found in neurons of the central nervous system, un-stabilize microtubules have been found in patients with Alzheimer's Diseases.

Amyloid precursor protein plays an important role in the formation of synapses between neurons in the nervous system, showed to generate beta-amyloid (Aβ) in patients with Alzheimer's diseases

In cognitive impairment in Alzheimer's disease animal models, caused by the accumulation of soluble oligomeric assemblies of the β-amyloid polypeptide (Aβ), oral administration of cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques and improvement in cognitive behavior(6).

Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).

Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndromes such as obesity and diabetes.

According to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and burning sensation in the mouth with a large amount. According to traditional Chinese medicine, overdoses of cinnamon can be toxic and damaged to the liver(1)(7).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ. (PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS. (PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL. (PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)

16 Remarkable Health Benefits of Herbal Aloe Vera, Scientists Revealed

By Kyle J. Norton, Master of Nutrition

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.

The herb has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

It is also one of many popular herbs studied in scientific ways with some conflicting results.

The Ingredients
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

1. Acne Vulgaris
There are many types of skin diseases in this world, the most common one is acne.

Most people know acne is caused by dirt in oily skin pores, but little is known that acne is also caused by the system of toxins in the body.

If our liver and kidney can not cleanse all toxins in the body, then our skin become the third source for cleansing the remainder of toxins.


Ance vulgaris, one of the skin diseases with areas of scaly red skin with seborrhea, blackheads, and whiteheads.

Aloe vera one of many herbs has been studied and researched in the pharmaceutical world, because of the common problem to the young ages and commercial profits.

The study to compare the efficacy and safety of the combination of tretinoin (TR) cream (0.05%) and Aloe vera topical gel (50%) with TR and vehicle, has been well tolerated and significantly more effective than TR and vehicle for the treatment of mild to moderate acne vulgaris and with less side effects.

Other researchers in the observation of traditional medicines of many cultures used to treat skin diseases, indicated that certain ingredients, including aloe vera, have been identified in the treatment of psoriasis and atopic dermatitis,



2.  Skin diseases
Skin diseases are defined as a condition of skin damage and classified according to each pathogenic causes of diseases.

In the systematic review of Aloe vera's clinical effectiveness, topical application of aloe vera is not an effective preventative for radiation-induced skin injuries, but might be effective for genital herpes and psoriasis.

In support to the above, the study by Feily A, Namazi MR. indicated that topical application of aloe vera is not effective in sunburn or suntan protection, but might be effective in treating genital herpes, psoriasis, human papillomavirus, seborrheic dermatitis, aphthous stomatitis, xerosis, lichen planus, frostbite, burn, wound healing and inflammation.


3. Aloe vera and Irritable bowel syndrome
Irritable bowel syndrome is defined as a condition, if a patient is diagnosed with abdominal pain or discomfort, bloating, and alteration of bowel habits at least three times a month for the last 3 months without preexistence of other diseases.

Aloe vera (AV) has long been suggested by herbal medicine in treating irritable bowel syndrome (IBS) symptoms.

In the comparison of the effectiveness of a mixture of Aloe vera (AV) and Matricaria recutita (German chamomile, GC) in treating Irritable bowel syndrome, GC inhibited only small bowel transit while the AV/GC mixture delayed gastric emptying at the doses of 150 and 300 mg/kg. The AV/GC mixture also reduced colonic transit and small bowel transit at the dose of 150 mg/kg.

In other randomized double-blind placebo-controlled trial of to test the effects of aloe vera for irritable bowel syndrome, researchers found that there is no evidence that AV benefits patients with IBS and superior to placebo in improving quality of life in irritable bowel syndrome patients.

But in 49 completed the protocol to 1 month and 41 to 3 months studies, aloe vera (AV) is effective in eleven of thirty-one (35%) AV patients and 6 of 27 (22%) placebo patients responded at 1 month (p = 0.763).

Diarrhoea-predominant patients showed a trend towards a response to treatment at 1 month (10/23 V 2/14, p = 0.07).


4. Psoriasis
Psoriasis is a chronic condition of inflammatory skin disease, affecting the joints and mostly happens to people who are obese are predisposed to diabetes and heart disease.


Many herbal extracts have been used as topical management of plaque psoriasis, including Aloe vera based on multiple studies.

Aloe vera gel is used in alternative medicine over the century for the treatment of skin diseases, including psoriasis.

And a recent study showed that ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness and an overall antipsoriatic activity of high effective rate.

In the comparison of comparison to evaluate the efficacy of topical aloe vera (AV) and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque psoriasis, AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis.

Unfortunately, in diverse dermatologic conditions, even though there are some promising results with the use of aloe vera, but the clinical effectiveness of oral and topical aloe vera may require further studies, according to the study of Dr. Feily A, and Dr. Namazi MR.


5. Gingivitis
Gingivitis is defined as a condition of Inflammation of Gum Diseases.

Aloe Vera anti-inflammatory property may be the result of the plant used in the treatment of gum diseases.

In the study of 45 patients diagnosed with plaque-induced gingivitis were included, aloe mouthwash is proven to be the most potential in a reduction of gingival inflammation caused by plagues.

In the randomized, controlled, and double-blind study, a total of 148 systemically healthy subjects, showed a statistically significant decrease in PI, MGI, and BI scores after the rinse regimen began in comparison with the use of chlorhexidine.

But Dr. de Oliveira SM and the research team in comparison of Aloe vera and fluoridated dentifrice found that there was a significant reduction on plaque and gingivitis in both groups, but no statistically significant difference was observed among them (p>0.01).

Aloe vera did not show any additional effect on plaque and gingivitis control compared to the fluoridated dentifrice.



6. Gastric Ulcers
Gastric ulcer is a condition of a localized tissue erosion in the lining the stomach. as a result of bacteria Helicobacter pylori (H pylori) in most cases.

Some people with gastric ulcers may be not experiencing any symptoms at all, while others may experience burning pain, severe nausea, and vomiting.

In the comparison of the effects of aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels, and gastric ulcer healing, researchers showed that aloe vera reduces leukocyte adherence and TNF-alpha level, elevate IL-10 level and promotes gastric ulcer healing.

Because of its anti-inflammatory effects, treatment of A. vera processes the enhancement in leukocyte-endothelium interaction associated with a reduction in TNF-alpha level.

In the study of acute gastric mucosal lesions induced by 0.6 M HCl and acid output, scientists indicated that aloe vera is endowed with gastric acid anti-secretory activity and could protect the gastric mucosa at low concentrations against injurious agents.

Other components of aloe vera, the polymer fraction (Avpf; molecular weight cut-off ≥50 kDa; 150 mg/kg body weight, p.o.), reduces 50% of the mRNA expressions of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS), according to the study.


7. Wound Healing
Wound healing is the natural process of skin repair after it was damaged

In a systematic review, there is cumulative evidence support that aloe vera might be an effective intervention used in burn wound healing for first to second-degree burns as the use of aloe vera shortens the healing time.

In acute and chronic wounds, although there is an absence of high-quality clinical trial evidence to support the use of Aloe vera topical agents or Aloe vera dressings as treatments for acute and chronic wounds, but some studies found the reduction in healing time with Aloe vera was noted after haemorrhoidectomy (RR 16.33 days, 95% CI 3.46 to 77.15) and application of Aloe vera cream on the surgical site is effective in reducing postoperative pain both on resting and during defecation.

In a study of a herbal gel of Aloe vera extract containing Carbopol 93, shows a promising effect on the wound healing process.


8.  Immunity
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

It does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.

In the study to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. In the pharmacological study of Aloe arborescens Miller leaf components,

The Aloe extract (1.2 mg ml(-1)) acted as a powerful immune stimulant in LPS- or poly I:C-activated SAF-1 cells, inducing a synergic effect on interconnected genes that are expected to be involved in different aspects of the immune responses.

Aloe polymannose, a chemical compound found in Aloe Vera, also enhances the cognitive and immune functioning in patients of Alzheimer's disease by decreasing tumor necrosis factor-α, vascular endothelial growth factor, and interleukins-2 and-4.

9. Aloe Vera and Type II Diabetes
Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

As a popular herbal remedy in the United Kingdom, oral administration of aloe vera might be a useful adjunct application for lowering blood glucose in diabetic patients as well as reducing blood lipid levels in patients with hyperlipidemia.

In another study of Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus, oral administration of PAG for 8 weeks was found to balance circulating blood glucose concentrations to a normal level in these DIO mice.

The herbal leaf is also found to be useful for treating diabetes. A study said A. vera leaf pulp extract showed hypoglycemic activity on type I (IDDM) and type II (NIDDM) diabetic rats, in comparison with glibenclamide.

On the contrary, A. vera leaf gel extract showed hyperglycaemic activity on NIDDM rats.

10. Aloe Vera and Cancers
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

Aloe-Emodi, a chemical compound found in Aloe vera, specifically suppresses breast cancer cell proliferation by targeting ER α protein stability through distinct mechanisms may be used as a possible application of anthraquinones in preventing or treating breast cancer in the future.

Also in another study, Aloe-Emodi is considered as a potential value for the treatment of gastric cancer and cervical cancer because of its mechanisms of inducing cell cycle interruption, differentiation.

Radiotherapy is most often used to treat head and neck cancer patients. In a study of Aloe Vera, Dr. Ahmadi A. found that oral Aloe vera mouthwash not only prevents radiation-induced mucositis but also reduces oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.


11. Aloe Vera and Skin Aging
Aloe Vera Supplementation has long been used to promote anti-skin aging by cosmetic industrials.

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cells, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA, etc., leading to aging of the organisms,

The widespread od skin damage is a result of free radical inducing a set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.

Free radicals oxidative effects can also speed up the skin aging process.

30 healthy female subjects over the age of 45 in the study were given 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin, researchers found that the facial wrinkles improve significantly (p<0.05) in both groups, and facial elasticity also improve in the lower-dose group.

In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group.

In UVB-induced skin photoaging in vitro, aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect in blocking UVB rays in normal human dermal fibroblasts (NHDFs).

As an anti-inflammatory agent, aloe vera, has been identified as beneficial in the treatment of psoriasis and atopic dermatitis.

12. Aloe Vera and Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), male pattern hair development, acne, irregular period or absence of period, weight gain and effecting fertility.

The syndrome affects over 5% of women population or 1 in 20 women.

According to the study by Desai BN, Maharjan RH, Nampoothiri LP. almost 70% of PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.

 Several classes of pharmacological agents have been used to manage dyslipidemia. However, studies have shown adverse effects associated with these drugs.

Aloe Vera may be a potential herb for treating Polycystic Ovarian Syndrome by enhancing the reductions of plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol or by restoring the ovarian steroid status.

According to the study of PCOS was induced in Charles Foster female rats by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days), AVG treated PCOS rats exhibited significant reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol.

The Aloe Vera gel treatment also induces reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities, bringing them to normal.

Another study also indicated that Aloe vera gel formulation exerts a protective effect against the PCOS phenotype by restoring the ovarian steroid status and altering key steroidogenic activity.

Dr.Pérez YY and the research team in the study of the effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice also indicated that the gel decreases significantly both body weight (p < 0.008) and blood glucose levels.

Also in the confirmation of above result, the study of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models, vera leaf pulp extract showed hypoglycemic activity on IDDM and NIDDM rats.

 The effectiveness is in comparison with glibenclamide.

13. Aloe vera and breast cancer
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases that breast cancer may start in other areas of the breast.

 In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.


Aloe-Emodin, chemical components found in Aloe-vera and other herbs such as rhubarb, have been researched for treatment of certain kinds of diseases, including cancers.

The efficacy of the components is found to inhibit breast cancer cell proliferation by downregulating ER α protein levels, thereby suppressing ER α transcriptional activation.

In the study of another constituent, a natural anthracycline from Aloe plant found to exhibit the cytotoxic activity against two human breast cancer cell lines; without (MCF-7) and with (SKBR-3) erbB-2-topoIIalpha amplification.

14. Aloe vera and prostate cancer
Prostate cancer is a condition in which the cells of the prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Aloe-emodin, an anthraquinone presented in aloe latex from the aloe plant has been found to suppress breast cancer cell proliferation through ER α Inhibition.

 In prostate cancer study, the phytochemical inhibited both proliferation and anchorage-independent growth of PC3 cells by targeting mTORC2 as mTORC2 which plays an important role in PC3 androgen-refractory prostate cell proliferation and anchorage-independent growth.

15. Aloe vera and colon cancer
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.

Aloe-emodin (AE), found in Aloe vera has been suggested to have antiproliferative activity in various cancer cell lines in many studies.

 In the study of colon cancer, AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6, depending on caspase-

Another study on colon cancer also showed an efficacy of AE in suppressed the nuclear translocation and DNA binding of NF-κB, which is an important transcription factor for controlling MMP-2/9 and VEGF gene expression.

16. Aloe vera and lung cancer
Lung cancer is a condition characterized by abnormal growth of the cells in the lung's tissue.

The most common form of primary lung cancers is derived from epithelial cells.

 In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.

Aloe-emodin has been studied extensively through the scientific community for their effects against cancer by induced apoptosis in lung carcinoma cell lines CH27 (human lung squamous carcinoma cell) and breaking of DNA strands (DNA ladders and sub-G(1) formation) and regulating of the expression of Bcl-2 family proteins (a suppressor of apoptosis).

In the study of the effects of aloe-emodin-induced cell death in the human lung nonsmall cell carcinoma cell line H460, aloe-emodin exerts a significant activity in regulating apoptotic cell death through the class of mitogen-activated protein kinases(p38).

These results suggested that aloe-emodin found in Aloe Vera may be a potential agent for preventing and treating lung cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. by Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A.(PubMed)
(4) Innovations in natural ingredients and their use in skin care. by Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(5) Oral aloe vera-induced hepatitis(PubMed)
(6) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(7) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(8) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(9) Aloe vera: a systematic review of its clinical effectiveness by Vogler BK, Ernst E. (PubMed)
(10) Aloe vera in dermatology: a brief review. by Feily A, Namazi MR (PubMed).
(11) Oral aloe vera-induced hepatitis(PubMed)
(12) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)

(13) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)

(14) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(15) Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects by Asadi-Shahmirzadi A, Mozaffari S, Sanei Y, Baeeri M, Hajiaghaee R, Monsef-Esfahani HR, Abdollahi M.(PubMed)
(16) Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome.
Davis K, Philpott S, Kumar D, Mendall M.(PubMed)
(17) A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life by Hutchings HA, Wareham K, Baxter JN, Atherton P, Kingham JG, Duane P, Thomas L, Thomas M, Ch'ng CL, Williams JG.(PubMed)
(18) Oral aloe vera-induced hepatitis(PubMed)
(19) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(20) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(21) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(22) Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis. by Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, Vadivelan R.(PubMed)
(23)A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis by Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P.(PubMed)
(24) Aloe vera in dermatology: a brief review by Feily A, Namazi MR.(PubMed)
(25) Oral aloe vera-induced hepatitis(PubMed)(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(26) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(27) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(28) Aloe vera: It's effect on gingivitis by Ajmera N, Chatterjee A, Goyal V.(PubMed)
(29) A randomized, double-blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse by Chandrahas B, Jayakumar A, Naveen A, Butchibabu K, Reddy PK, Muralikrishna T.(PubMed)
(30) Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans by de Oliveira SM, Torres TC, Pereira SL, Mota OM, Carlos MX.(PubMed)
(31) Oral aloe vera-induced hepatitis(PubMed)(8) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(32) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(33) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(34) Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats, by Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D.(PubMed)
(35) Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats by Prabjone R, Thong-Ngam D, Wisedopas N, Chatsuwan T, Patumraj S.(PubMed)
(36) The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats by Yusuf S, Agunu A, Diana M.(PubMed)
(37) Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions.
Park CH, Nam DY, Son HU, Lee SR, Lee HJ, Heo JC, Cha TY, Baek JH, Lee SH.(PubMed)
(38) Oral aloe vera-induced hepatitis(PubMed)
(39) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)

(40) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)

(41) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(42) The efficacy of aloe vera used for burn wound healing: a systematic review.
Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)
(43) Aloe vera for treating acute and chronic wounds. by Dat AD, Poon F, Pham KB, Doust J.(PubMed)
(44) Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study, by Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O.(PubMed)
(45) Formulation development, optimization and evaluation of aloe vera gel for wound healing.
Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J.(PubMed)
(46) Oral aloe vera-induced hepatitis(PubMed)
(47) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(48) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(49) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(50) The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. by Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R, Ferro VA.(PubMed)
(51) Immune modulatory effects of Aloe arborescens extract on the piscine SAF-1 cell line. by Picchietti S, Bernini C, Belardinelli MC, Ovidi E, Taddei AR, Guerra L, Abelli L, Fausto AM.(PubMed)
(52) The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease. by Lewis JE, McDaniel HR, Agronin ME, Loewenstein DA, Riveros J, Mestre R, Martinez M, Colina N, Abreu D, Konefal J, Woolger JM, Ali KH.(PubMed)
(53) Oral aloe vera-induced hepatitis(PubMed)
(54) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(55) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(56) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(57) Aloe vera: a systematic review of its clinical effectiveness. by Vogler BK, Ernst E.(PubMed)
(58) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. by Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.(PubMed)
(59) Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models.
Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N.(PubMed)
(60) Oral aloe vera-induced hepatitis(PubMed)
(61) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(62) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(63) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(64) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(65) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(66) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J, Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(67) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH.(PubMed)
(68) Oral aloe vera-induced hepatitis(PubMed)
(69) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(70) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(71) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(72) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH.(PubMed)
(73) A Comparative Study of Baby Immature and Adult Shoots of Aloe Veraon UVB-Induced Skin Photoaging in vitro. by Hwang E, Kim SH, Lee S, Lee CH, Do SG, Kim J, Kim SY.(PubMed)
(74) Innovations in natural ingredients and their use in skin care.
Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(75) Oral aloe vera-induced hepatitis(PubMed)
(76) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(77) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(78) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(79) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model (PubMed)
(80) Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice (PubMed)
(81) Oral aloe vera-induced hepatitis(PubMed)
(82) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(83) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(84) Cytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: topoisomerase IIalpha coamplification by Esmat AY, Tomasetto C, Rio MC.(PubMed)
(85) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)
(86) Oral aloe vera-induced hepatitis(PubMed)
(87) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(88) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double-blind placebo-controlled study(PubMed)
(89) Oral aloe vera-induced hepatitis(PubMed)
(90) Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2) by Lin SY, Yang JH, Hsia TC, Lee JH, Chiu TH, Wei YH, Chung JG. (PubMed)
(91) Aloe-emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells by Suboj P, Babykutty S, Srinivas P, Gopala S.(PubMed)
(92) Aloe-emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB, and VEGF via reduced DNA binding activity of NF-κB by Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S.(PubMed)
(93) Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
Lee HZ, Hsu SL, Liu MC, Wu CH. (PubMed)
(94) Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. by Yeh FT, Wu CH, Lee HZ(PubMed)

The Bioactive Phytochemical Allyl isothiocyanate Which Stops Prostate Cancer Cells From Proliferating

By Kyle J. Norton, Master of Nutrition

Phytochemicals may be next potential sources of new medications for the treatment of diseases with little or no side effects, some scientists suggested.

Phytochemicals, the natural chemical constituents formed the plants outer's color protect the plants against environmental threats like predator insects, pollution and disease.

Although they are important to sustain plants life, phytochemicals are truly non-essential nutrients.

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in cruciferous vegetables, horseradish, mustard, wasabi, etc.

Prostate cancer is a chronic and medical characterized by cells growth disorderly and irregularly in the prostate tissue. In most cases, change of DNA starts in the cells on prostate surface.

At the advanced stage, cancerous cells can travel a distance away from the original site to infect other healthy cells of the tissue and organs through fluid and blood circulation.

Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

In an aim to reaffirm the effects of allyl isothiocyanate (AITC), a constituent of cruciferous vegetables inhibiting survival of PC-3 and LNCaP human prostate cancer cells in culture, researchers at the University of Pittsburgh School of Medicine launched an investigation to examine whether allyl isothiocyanate (AITC) administration retard growth of human prostate cancer xenografts in vivo.

Bolus i.p. injection of 10 micromol AITC, three times per week (Monday, Wednesday and Friday) to experimental human prostate cancer xenografts beginning the day of tumor cell implantation was carried out for 26 days.

At the final report of the study, researchers found that

* The application exerts a significant effect to inhibit the growth of PC-3 xenograft

* Mice treated with AITC shows a statistically significant increase in the number of apoptotic bodies, using the histological analysis of tumors excised at the termination of the experiment.

* AITC-treated mice induces approximately 70% reduction in the levels of anti-apoptotic protein Bcl-2 in the tumor lysate, compared with that of control mice, according to Western blot analysis.

After taking into account of other co and confounders, researchers wrote, " (AITC shows a) Statistically significant reduction in the expression of several proteins that regulate G2/M progression".

Furthermore, in cultured PC-3 (androgen-independent) and LNCaP (androgen-dependent) human prostate cancer cells, the injection of allyl isothiocyanate (AITC), also significantly inhibits proliferation of all cancer cell lines in a dose-dependent manner with an IC(50) of approximately 15-17 micro M.

Moreover, researchers also discovered that survival of a normal prostate epithelial cell line (PrEC) was minimally affected by AITC even at concentrations that were highly cytotoxic to the prostate cancer cells and AITC reduces proliferation of PC-3 as well as LNCaP cells correlated with accumulation of cells in G(2)/M phase and induction of apoptosis. 

These results suggested that AITC, and possibly other ITCs, may find use in the treatment of human prostate cancers.

Taken altogether, phytochemical allyl isothiocyanate (AITC) found abundantly from the cruciferous vegetables, horseradish, mustard, wasabi may be considered as function supplement for treatment of prostate cancer, pending to the results of further large sample size and multi-center studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV. (PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis by Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV. (PubMed)

Fennel, The Best Herbal Remedy Which Detoxes Your Kidneys Through Promoting Excess Fluids Secretion, Public Medical Library Revealed

By Kyle J. Norton

Fennel may have a potential and positive effect of eliminating excess water and toxin from our body, some scientists suggested.

Diuresis is a medicine with a function to stimulate increased production of urine.

Detoxification is a process of eliminated toxin accumulation from our body. In some cases, the function may only target some specific organs, such as kidneys, liver,..... and lung.

According to traditional medicine, detoxification is a necessary process to enhance and optimize the functions of our body by cleansing away substances which may reduce or cause harm to our body organs and tissue.

According to the Tao of Wellness in the address of the importance of detoxification of Traditional Chinese Medicine wrote,  " Our body is automatically programmed to cleanse itself daily. However, with our fast-paced modern lifestyle and exposure to an increasing number of harmful and toxic substances, our body’s natural cleansing ability has become overworked and compromised" and "Many signs and symptoms attributed to stress are now being linked to exposure from harmful substances such as PCBs, pesticides, herbicides, antibiotics, growth hormones, and mercury in food and liquids as well as dioxins and formaldehyde in the air".

Truly, harmful and toxic substances not removed from our body may have substantially negative implication to cause of many serious illnesses, such as cancer, neurodegenerative diseases,..... and reproductive ailments.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herb or food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...


Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.

In animal model, according to the John Wiley & Sons, Ltd. in the evaluation of the re-toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, researchers found that application of the extract exerts a significant activity in flushing out of excess water and toxin from the body through increased kidney function in secretion of fluids.

The result of these properties was observed by an increase in urine flow and urinary sodium excretion.

The efficacy in the cleansing body was also found linearly in dose depending manner.

Continuously, in further examine the efficacy of fennel powder, extract and oil on gentamicin-induced nephrotoxicity through a study of total 35 adult female Sprague Dawley rats classified into five groups with the first group kept on the standard diet all over the period of the experiment. and the other groups administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either control (+ve) group or treated groups with fennel powder, extract and oil for 45 days, at the end of the study, researchers found that

* Injected gentamicin group served as control exhibited a strong nephrotoxicity manifested by increasing levels of kidney function indicator, serum nitric oxide (NO) and kidney malondialde(MDA) however, this group of rats also exerted a significant decrease in weight gain.

Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severe oxidative stress caused by imbalanced of the ratio of ROS and antioxidants in the host.

* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improve the levels of urea and uric acid in comparing to control (+ve) and displayed an improvement of antioxidant enzymes, serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.

These results addressed the important antioxidant effect of fennel extracts.

Furthermore, the applications not only inhibited the levels of free radical and theirs' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.

* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with normal group and other treatment groups.

Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account of other co and confounders said, "fennel powder, extract and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats".

Clearly, fennel oil exhibited the greatest effect in stimulated kidney function to detox the body toxins through increased secretion of urine compared to other experimental groups.

The results of this study clearly indicate that fennel powder, extract and oil are potent antioxidants which ameliorate the levels of gentamicin-induced nephrotoxicity in rats.

Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduces hypertension through Foeniculum increased water, sodium and potassium excretion in compared to no effect of Marrubium treated group.

Additionally, in compared to Marrubium extract reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.

Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.

Taken together, fennel and its extracts may be considered as a kidney detoxed functional food in getting rid of body toxins through its diuretic activities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N(PubMed)