Lentils Antioxidants in Reduced ROS Over Expression in Induction of Acute and Chronic Inflammatory Diseases

Kyle J. Norton

Lentils may have a potential effect in inhibited free radicals expression in reduced risk and treatment of acute and chronic inflammatory diseases, some researcher opinionated.
Lentil is a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber, is a bushy annual plant of genus Lens to the Fabaceae family, native to Middle East.

Antioxidants are types of chemical compound inhibited the expression of reactive oxygen and nitrogen species to protect the body against oxidative damage.

Reactive oxygen species (ROS) are key signaling molecules played an important role in generation by polymorphonuclear neutrophils (PMNs) to induce progression of inflammatory disorders and  cytotoxicity in tumor cells. Over expression of ROS and decreased antioxidant persistence also may cause endothelial dysfunction and tissue injury in the inflammatory sites.

According to the investigation of  lentil (Morton) extract protective effect on cardiac hypertrophy,  one of the most significant sequelae of cardiovascular diseases suggested that high phenolic compounds (43.4 mg of GAE/g), including thirteen phenolic acid and two flavonoids found in the acetone/water/acetic acid lentil extract express a significant effect in attenuated Ang II-induced rat in elevated contraction of blood vessels to cause hypertension and human cardiomyocytes hypertrophy, the loss of contractile mass from prior infarction through activated antioxidant activities in  decreased intracellular ROS levels.

ROS elevation and in decreased levels of antioxidant have shown to increase oxidative stress in stimulated lipid peroxidation in induction of endothelial cells damage and promoted lipid accumulated in the inner wall of arteries, through their effects on inflammation, disturbed blood flow and arterial wall remodeling.

Lentils antioxidant properties in the experiment of measurement of injection effects of  2,2-diphenyl-1-picrylhydrazyl (DPPH) in reduced antioxidant power in oxygen radical absorbing capacity, in vitro  containing different groups of phenolic compounds also exerted the ability to inhibit the formation of reactive oxygen species, superoxide anion through chelating metal ions or inhibiting ROS -related enzyme expressions.

Further more, the analysis of free redical scavegening activities of methanolic extracts of the seed coat and the cotyledon of two varieties of lentils (Lens culinaris L.) and two varieties of dark peas (Pisum sativum L.), suggested that the deed coat of lentils scored a huge antioxidant capacities
in compared to the cotyledon in lentils and peas through the significantly higher levels of phenolic compounds with flavonoid structure.

More interestingly, the evaluation of phenolic extracts from 20 Canadian lentil cultivars (Lens culinaris) for total phenolic contents and composition, antioxidant activities (DPPH, FRAP, ORAC), and inhibitory properties against α-glucosidase and pancreatic lipase suggested that phenolic compounds identified including the majority being flavonoids, kaempeferol glycosides, catechin/epicatechin glucosides and procyanidins not only demonstrate significantly antioxidant activities, but also express a strong inhibition of of α-glucosidase and lipase activities associated with glucose and lipid metabolism in the intestine.

Dr. Florinda Fratiannia, in the study of phenolic contents and antioxidant activities of grass pea (Lathyrus sativus), lentil (Lens culinaris), and chickpea (Cicer arietinum) cultivars from the Campania region of Southern Italy, postulated, "Lentils (cv Colliano and San Gerardo) demonstrated the highest antioxidant activity, (EC50 not higher than 2.3 mg/g), confirming that lentils are an excellent antioxidant food" and " these legumes can be considered therapeutic functional foods due to their significant content of functional proteins and carbohydrates and their extraordinary reserve of secondary metabolites and bioactive constituents that are beneficial for managing and preventing several chronic illnesses in humans".

People who are susceptible or at higher risk of infection may want to add some portions of lentils into

their diet to ameliorated ROS precipitation of inflammation.

The information findings suggested that lentils with huge numbers of phytochemicals may be considered as a function food in stimulated antioxidant expression through immune system in fighting against foreign invasion and prevented ROS over production in induction of acute and chronic inflammatory diseases.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Assessment of in vitro antioxidant capacity of the seed coat and the cotyledon of legumes in relation to their phenolic content by M.DueñasT.HernándezI.Estrella(Science direct)
(2) Polyphenol composition and antioxidant activity of different grass pea (Lathyrus sativus), lentils (Lens culinaris), and chickpea (Cicer arietinum) ecotypes of the Campania region (Southern Italy)
Florinda Fratiannia, Federica Cardinalea, Autilia Cozzolinoa, Tiziana Granesea, Donatella Albaneseb, Marisa Di Matteob, Massimo Zaccardellic, Raffaele Coppolaa, Filomena Nazzaroa(Science direct)(3) Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase by Zhang B1, Deng Z2, Ramdath DD3, Tang Y4, Chen PX5, Liu R3, Liu Q3, Tsao R6.(PubMed)
(4) Review Polyphenol-Rich Lentils and Their Health Promoting Effects Kumar Ganesan ID and Baojun Xu (The International journal of molecular sciences)
(5) Morton lentil extract attenuated angiotensin II-induced cardiomyocyte hypertrophy via inhibition of intracellular reactive oxygen species levels in vitro by Yao FR1, Sun CW, Chang SK.(PubMed)

Food Therapy: Lentils (Legumes) Intake in Improvement of Diet Quality

Kyle J. Norton

Intake of lentils frequently and daily may have a substantial and positive effect in improved diet quality, recent recommendation and guidance suggested.

Lentil, a type of pulse or tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens to the Fabaceae family, native to Middle East.

The differentiation of lentils in improvement of diet quality may be observed through several different aspects and implications.

According to the review of published medical literature online of MEDLINE, EMBASE, CINAHL, and the Cochrane Library for relevant controlled trials of >or=7 days, dietary non-oil-seed pulses (chickpeas, beans, peas, lentils, etc.) are a good source of slowly digestible carbohydrate, fibre and vegetable protein and a valuable means of lowering the glycaemic-index (GI) of the diet.

Further examination of the selected trials and studies satisfied the criteria and guideline of 41 trials (39 reports), found that studies using pulses alone (11 trials demonstrated a significant effect in reduced fasting blood glucose (FBG)  and improved insulin levels, in compared to pulses in low-GI diets (19 trials) in lowered glycosylated blood proteins (GP), expressed blood glucose to the red blood cells, observed by HbA(1c)  in measurement of three-month average plasma glucose concentration or fructosamine, in measurement of glucose levels over the previous 2-3 week and pulses in high-fibre diets (11 trials) lowered FBG and GP.

Observation of the  outcomes of the trials and studies obtained indicated a significant effect of pulses in high-fibre diets in reduced risk of over expression of glucose levels in the tested subjects in compared to other 2 groups.

After taking into account of other con founders such as high inter-study quality and unexplained outcomes, Dr. Mitchell DC, the lead author said, "Pooled analyses demonstrated that pulses, alone or in low-GI or high-fibre diets, improve markers of longer term glycaemic control in humans, with the extent of the improvements subject to significant inter-study heterogeneity".

According to the recommendation of The US Department of Agriculture's (New) MyPyramid guidelines, in doubling dietary intake for vegetables, particularly, in subgroups of vegetables, including dry beans, peas and lentils.

Even through, dry beans, peas and lentils were found to contain a rich source of nutrients and phytochemicals that have been shown to have beneficial health effects by numbers of respectable institutes and recommended by health advocates, but consumption levels in the United States are quite low. 

The review from the National Health and Nutrition Examination Study (NHANES) found that only 0.9% of adolescents, 2.2% of adult men, and 3.5% of adult women met their dietary guidelines for both fruits and vegetables in compared to the EU-28, with average a third (34.4 %) of the population aged 15 or over did not consume any fruit or vegetables in a day; half (51.4 %) the population ate daily from 1 to 4 portions of fruit and vegetables, while the residual 14.1 % consumed more than 5 portions a day.

In the study to assess nutrient and food group intakes of dry bean and pea consumers compared to non consumers using data of dietary intake from the 1999-2002 of National Health and Nutrition Examination Survey for adults aged > or =19 years, researchers surprisingly found that only 7.9% of adults are consuming dry beans and peas everyday. Dry beans or peas intake showed a significant biber, protein, folate, zinc, iron, and magnesium levels and lowering saturated fat and total fat consumption.

Most Mexican Americans or other Hispanics are more likely to be consumers than non consumers.

After in depth differentiation of the data, Dr.Mitchell DC, the lead scientist said, "These data support the specific recommendation for dry beans and peas as part of the overall vegetable recommendation" and "Increased consumption of dry beans and peas-economical and nutrient-rich foods-could improve the diet quality of Americans".

Taken together, there is no doubt that lentil and other dry beans and peas diet may have a substantial effect in improved diet quality to population in all nations.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Lentil is a type of pulse. It is a bushy annual plant of genus Lens the Fabaceaefamily, native to Middle East. It is also tiny legumes that can be cooked quickly and rich in protein and fiber.

Source
(1) Effect of non-oil-seed pulses on glycaemic control: a systematic review and meta-analysis of randomised controlled experimental trials in people with and without diabetes by Sievenpiper JL1, Kendall CW, Esfahani A, Wong JM, Carleton AJ, Jiang HY, Bazinet RP, Vidgen E, Jenkins DJ.(PubMed)
(2) Consumption of dry beans, peas, and lentils could improve diet quality in the US population by Mitchell DC1, Lawrence FR, Hartman TJ, Curran JM.(PubMed)
(3) Increasing Fruit and Vegetable Consumption: Challenges and Opportunities by Sandeep Sachdeva, Tilak R Sachdev, and Ruchi Sachdeva(PMC)
(4) The fruit and vegetable sector in the EU - a statistical overview, Data extracted in July and August 2016. Most recent data: Further Eurostat information, Main tables and Database.

Herbal Therapy: Green Tea Bioactive Polyphenols In Reduced Weight Gain and Promoted Weight Loss

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea polyphenols may have a therapeutic effect in reduced weight gain through decreased hormone expression with function direct influence of excess energy deposit, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Weight gain is an increase in body weight, involved an increase in muscle mass, fat deposits, excess fluids.

In the compared green tea, polyphenols [epigallocatechin gallate (EGCG), epigallocatechin (EGC)] in decoction of green tea leaves versus usual green tea extracts to evaluate the effect in weigh gain in obese animal models fed with high fat diet, researchers after taking into account of other con-founders suggested that green tea decoction  acute administration of GTD with 2/3 EGCG+1/3 EGC inhibited SGLT-1 activity involved distinct and complementing glucose homeostasis through absorbing glucose from the diet in the small intestine and by reabsorbing the filtered glucose in the tubular system of the kidney, thus reducing access energy being converted to glycogen or fat and deposit in liver, muscles and fat cells. 

Additionally, green tea decoction not only improved glucose tolerance but also demonstrated a significant increase GLUT2 protein in facilitated glucose movement across cell membranes in the regulation of glucose absorption in distribution of dietary sugar to tissues to induce calorie restriction.

Chronic administration of green tea decoction GTD for 6 weeks, in the same experiment models also displayed a huge reduction of body weight gain, circulating triglycerides and cholesterol and improved glucose tolerance, through significantly reduced SGLT-1 as seen in acute application and and increased GLUT2 mRNA levels in the jejunum mucosa with function in increase the surface area of tissue available to absorb nutrients from ingested foodstuffs for decreased fat accumulation and glucose in liver.

Dr. Snoussi C, the lead auhtor said, "GTD-treated rats for 6 weeks display significantly reduced SGLT-1 and increased GLUT2 mRNA levels in the jejunum mucosa". This result showed that green tea decoction with polyphenols such as epigallocatechin gallate (EGCG), epigallocatechin (EGC) may have a certain effect in reduced weight gain through decreased fat deposit in the liver and promoted calorie restriction.

Further analysis of C57BL/6J mice fed a high-fat/high-sucrose diet (HF/HS, 32% energy from fat; 25% energy from sucrose) or the same diet supplemented with 0.25% GTP or BTP or a low-fat/high-sucrose (LF/HS, 10.6% energy from fat, 25% energy from sucrose) diet for 4 weeks showed that treatment with decaffeinated green tea (GT)  polyphenols inhibited weight gain in mice fed an obesogenic diet as indicated above, through the rearrange the relative proportions of Blautia, Bryantella, Collinsella, Lactobacillus, Marvinbryantia, Turicibacter, Barnesiella, and Parabacteroides in correlated with weight loss by a decrease of cecum Firmicutes and increase in Bacteroidetes in the gastrointestinal tract.

In deed, GTP not only induced weight loss in association with alteration of the gut microbiota but also increased hepatic AMPK in reaction in sugar metabolism, and energy storage and release.

Interestingly, according to the START Clinic for the Mood and Anxiety Disorders, oral administration of green tea extract induced an unexpected decrease in total body fat mass, a decrease in body fat percentage and an increase in lean body mass in patients with weight gain induced by psychotropic medications.

Taken together, green tea, bioactive active polyphenols epigallocatechin gallate (EGCG), epigallocatechin (EGC) may be used as functional food in reduced weight gain induced by all sources and increased weigh loss through regulation of energy metabolism in fat accumulation.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice by Henning SM1, Yang J2, Hsu M2, Lee RP2, Grojean EM2, Ly A2, Tseng CH3, Heber D2, Li Z2.(PubMed)
(2) Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet by Snoussi C1, Ducroc R2, Hamdaoui MH3, Dhaouadi K4, Abaidi H3, Cluzeaud F2, Nazaret C2, Le Gall M2, Bado A5.(PubMed)
(3) Weight gain and psychiatric treatment: Is there a role for green tea and conjugated linoleic acid? by Katzman MA1, Jacobs L, Marcus M, Vermani M, Logan AC.(PubMed)

Food Therapy: Lentils' Lectin as Bio-makers and Potential Target in Risk and Treatment of Prostate Cancer

Kyle J. Norton

Lectin isolated from lentils and other sources may have a substantial effect used for treatment of cancers and as a new type of potential biomarkers and therapeutic targets to detect the state and progression of prostate cancer, some scientists suggested.

Lentil, a type of pulse or tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens the Fabaceaefamily, native to Middle East.

Prostate cancer is a chronic and medical condition characterized by cell growth irregularly in the prostate tissues.

Use of lectins with properties of recognizing specific carbohydrate moieties of glycoconjugates (for
carbohydrates covalently linked with other chemical species such as proteins, peptides, lipids and saccharides) as cancer screening technique and biomarkers to indicate altered structural changes of glycans in complex bodily fluids and tissues of cancer have been under extensive research.

According to the Indian Institute of Chemical Biology 4, in a designed to distinguish prostate cancer and benign prostate hyperplasia by lectin-prostate specific antigen (PSA) binding found that lectin-prostate specific antigen (PSA) binding may be an effective tool in reduced performance of biopsies in men with total PSA value between 4.0 to 10.0 micog/ml, through examine the carbohydrate content after binding of Con A (lectin) with serum PSA of prostate cancer.

In other words, the detection of a serum value <3.0 microg/ml of the carbohydrate content of Con A-PSA expression was an strong indication of benign prostate hyperplasia with suspicion for prostate cancer and this cut off level in compared to prostate cancer rate of over 4.0 micog/ml.

The evaluate lectins role in influence the cell growth of several types of normal and neoplastic tissues, particularly in prostate cancer cells with numbers of lectins, such as peanut (PNA), wheat germ (WGA), Concanavalin A (Con A),Griffonia simplicifolia (GSA-IA4), and Phaseolus vulgaris(PHA-L) agglutinins, on the cell proliferation of one androgen-sensitive (LNCaP) and two androgen-insensitive (PC-3 and DU 145) human prostate cancer cell lines cultured in either 10% or 1% fetal bovine serum (FBS)-supplemented media, at the joint study lead by the Free University of Brussels, showed that all 5 experiment lectins expressed a globally significant effect in inhibited all tested prostate cancer cell lines proliferation in dose-dependent toxicity.

However, further examination also found that application of low doses of GSA-IA4 and PHA-L demonstrated a contradictory result in significantly increased cell proliferation of confluent PC-3 cells and increasing the FBS from 1% to 10% in the culture media significantly antagonized lectin-induced toxicity in the three prostate cell lines, according to the measurement of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.

The  contradictory results in influence on prostate cancer cell proliferation, probably was attributed to types of lectin isolated and doses exposure.

After taking into account of other con-founders, Dr. Isabelle Camby, the lead author concerned, "because lectins are present in our diet, and are able to pass into the systemic circulation and thus reach the prostate, the present results suggest that some lectins might exert an influence on prostate cancer growth under clinical conditions".

Taken together, lectins isolated from lentils and other sources may be considered as screen technique in detect the state of progression of cancer through levels of total lectin-prostate specific antigen (PSA) concentration and used as biomarkers and therapeutic target for treatment of prostate cancer.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Lectin-induced alterations on the proliferation of three human prostatic cancer cell lines by Isabelle Camby, Thierry Janssen, Robert De Decker, Michel Petein, Gil Raviv, Jean-Lambert Pasteels, Robert Kiss, André Danguy(Sprinker link)
(2) Lectin and serum-PSA interaction as a screening test for prostate cancer by Basu PS1, Majhi R, Batabyal SK.(PubMed)

Alternative Therapy:Yoga In Reduced Psychological symptoms in HIV-1 Infected Patients

Kyle J. Norton 

Yoga may be used as an integrated form of exercise in reduced psychological symptoms of anxiety and depression.in patients with Human immunodeficiency virus (HIV) infected individuals, randomized controlled pilot studies suggested.

Yoga, the ancient practical technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

Human immunodeficiency virus (HIV) is a lentivirus with function in induced acquired immunodeficiency syndrome, if not treated.

According to the Yoga Anusandhana Samsthana (SVYASA) University study with an aim to contribute towards the understanding the therapeutic benefits of specific yoga modulation in HIV-1 infected subjects, yoga participated group displayed an indirect effect of HIV-1 induced hematopoietic inhibition of CD34+ progenitor stem cells, a hematopoietic progenitor cells found in bone marrow and cord blood with loss of human hematopoietic precursor cell function, via the CD4+ T lymphocytes in signalling immune response to destroy the infectious particle.

In other words, yoga practice normalized the inhibition of replication and enhancement of levels of hematopoiesis in HIV-1 infected subjects, through infected of CD34+ progenitor stem cells by activated immune action.

The hematopoietic stem cell has long been hypothesized to be a target of human immunodeficiency virus type-1 (HIV) infection.

Additionally, Yoga participant also showed to improve the self renewal capacity of numbers of cycles of cell division while maintaining the undifferentiated state to differentiate into CD34+ progenitor cells, through STAT5 gene in activatedhematopoietic cytokines in modulates cytokine responses, including nterleukin-2 and 15,  transforming growth factor-β (TGF-β) and tumor necrosis factor-α (TNF-α) in development of Tregs in immune regulation.

CD34+, undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells.

Transforming growth factor-β (TGF-β) is a secreted protein in regualted cellular process including the control of cell growth, cell proliferation, cell differentiation and apoptosis.

Tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling cytokine involved in systemic inflammation in the acute phase infection.

Interleukin-2 and 15 are cell signaling proteins in the immune system in regulated the activities of white blood cells of the immunity.

More interesting, in psychological aspects, yoga induced hematopoietic inhibition in HIV-1 infection was contributed by the role of reduced stress involved sycho-neuro-immunological axis (PNI), the interaction between psychological processes and the nervous and immune systems of the human body in induction of psychological symptoms, such as anxiety and depression and quality of life

In deed, physical postures (asanas), breathing practices (pranayama), relaxation techniques, and meditation have shown to bring back consciousness in the present moment and increased the ability to maintain or positive feelings to minimize or regulate stress feelings or letting them go, thus decreasing stress effect in suppressed body's immune system and neuro-humoral actions in transmitting information from cells to cells, thereby affecting normal psychological state.

Additionally, researchers at the study also said, "Yoga therapy is introduced and its effectiveness in terms of evidence in relevant area is reviewed. Further, the basic principles of Integrated Approach of Yoga Therapy [IAYT] are described and depending on the potential mechanisms through which yoga therapy may act, both modern scientific research and ancient "scriptural" evidence are provided at all the five levels of existence (body, life force, emotional, intellectual and bliss)" and "This will enable to design comprehensive yoga modules that may intervene in this indirect inhibition of hematopoiesis in HIV-1 infected individuals and potentially restore normal levels of hematopoiesis".

Further more, in a study of 44 HIV-1 infected individuals from two HIV rehabilitation centers of Manipur State of India randomized into two groups: Yoga (n = 22; 12 males) group received IY intervention, which included physical postures (asanas), breathing practices (pranayama), relaxation techniques, and meditation,  given 60 min/day, 6 days a week for 1 month and Control group (n = 22; 14 males), followed daily routine during this period, researchers found that yoga group showed a significant reduction in depression scores along with non significant increment in CD4 counts in surface of the immune cells but non-significant reduction in anxiety scores in compared to control group.

An at the end of the experiment, researchers concluded that short term yoga participated may have a positive effect in reduced depression and improved immunity in HIV-1 infected adults.

Taking altogether, Yoga intervention as an adjunct therapy may have a profound effect in reduced  psychological symptoms and treatment of inhibited hematopoiesis in HIV-1 infected individuals by regulating the immune function in restore normal function of hematologists in production of blood cells and platelets.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of Integrated Yoga (IY) on psychological states and CD4 counts of HIV-1infected patients: A randomized controlled pilot study by Naoroibam R1, Metri KG1, Bhargav H1, Nagaratna R2, Nagendra HR1(PubMed)
(2) Potential yoga modules for treatment of hematopoietic inhibition in HIV-1 infection by Bhargav H1, Raghuram N, Rao NH, Tekur P, Koka PS.(PubMed)

Herbal Therapy: Green Tea and Green Tea Bioactive Catechins and Epigallocatechin Gallate in Reduced Risk and Progression and Treatment of Kidney Cancer

Kyle J. Norton

Green tea may have a substantial and sustainable effect in reduced risk and treatment of renal cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Kidney cancer is medical condition characterized by irregular cell growth in the issues of kidney. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, kidney cancer is very uncommon in people younger than age 45 and among the 10 most common cancers in both gender.

Investigation of green tea effect in risk of renal cancer was found to associate to different implications involved numbers of mechanisms, particularly, in green tea bioactive components.

According to the evaluated 250 newly diagnosed, histo-logically confirmed Clear cell renal cell carcinoma (CCRCC) cases and 299 sex-, age-matched healthy controls provided complete information by face-to-face interview in Shanghai between 2007 and 2009, application of green tea at dose of ≥500 ml/d demonstrated a significantly inverse association to risk of CCRCC.

In deed, green tea consumption of lower than the said volume such as 8 oz (237 ml) or more cups/day was also associated to decrease renal cell cancer risk, in compared to non drinkers, according to the report of Brigham and Women's Hospital and Harvard Medical School.

Further analysis also found that interactions with the environmental exposures association to polymorphisms of the xenobiotic-metabolizing enzymes in induced CCRCC risk, also inhibited by green tea extract through increasing serum and liver antioxidant capacity and strengthening stability of microsomal and lysosomal membranes of healthy cells in compared to control.

In free radical aspect, the examine Wistar rats induced renal cancer pre-treated with N-ethyl-N-hydroxyethylnitrosamine (EHEN) by oral injection of drinking water for 2 weeks, also found that administration of green tea extract catechin ( 0.1% polyphenon-60) over 30 weeks of period of treatment exhibits a significant effect in decreased the incidence of renal cell tumors greater than 3 mm in diameter but not tumors that are less than 3 mm in diameter, through over expression of antioxidant in suppression of reactive oxygen species (ROS) induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) pre-treatment.

Importantly, in alternated gene expression in increased prevalence of cancer in human subjects,
application of green tea polyphenol, catechins have been reported to reverse change of DNA methylation in contributed to the tumor repressive gene of RGS2 (regulator of G-protein signaling 2) in modulated expression of cancers and increased the regulation of conversion of DNA to RNA (transcription) of these genes in ameliorated risk of renal and other cancer(s).

Further more, application of the combination of green tea extract bioactive catechins and epigallocatechin gallate also showed to modulate DNA methylation by attenuating the effect of DNA methyltransferase 1 (DNMT1) to ensure the fidelity of replication of inherited epigenetic patterns.

Aberrant DNA methylation patterns are associated with increased prevalence of  renal and other tumor(s).

Taken together, Green Tea and its polyphenols bioactive compound catechins and epigallocatechin gallate may have a potential and therapeutic effect in reduced risk and treatment of renal cancer through antioxidants and anti gene alternative activities.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study by Wang G1, Hou J, Ma L, Xie J, Yin J, Xu D, Chang W, Tan X, Su T, Zhang H, Cao G.(PubMed)
(2) [Effects of green tea extract and its components on antioxidant status and activities of xenobiotic metabolizing enzymes of rats] by [Article in Russian](PubMed)
Kravchenko LV, Trusov NV, Aksenov IV, Avren'eva LI, Guseva GV, Lashneva NV, Tutel'ian VA.

(3) Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies byLee JE1, Hunter DJ, Spiegelman D, Adami HO, Bernstein L, van den Brandt PA, Buring JE, Cho E, English D, Folsom AR, Freudenheim JL, Gile GG, Giovannucci E, Horn-Ross PL, Leitzmann M, Marshall JR, Männistö S, McCullough ML, Miller AB, Parker AS, Pietinen P, Rod riguez C, Rohan TE, Schatzkin A, Schouten LJ, Willett WC, Wolk A, Zhang SM, Smith-Warner SA.(PubMed)
(4) Effect of polyphenon-60 on the development of renal cell tumors in rats treated with N-ethyl-N hydroxyethylnitrosamine byYoshioka N1, Hiasa Y, Cho M, Kitahori Y, Hirao K, Konishi N, Kuwashima S.(PubMed)
(5) Targeting DNA Methylation with Green Tea Catechins by Yiannakopoulou E.C.(Karger)

Herbal Therapy: Green Tea Bioactive Epigallo-catechin-3-gallate (EGCG) in Reduced Risk, Progression and Treatment of and Neuro-Degenerative Diseases

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea is found to consist a substantial and respectful effect in reduced risk, progression and treatment of neuro-degenerative diseases, some scientists opinionated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Neuro degenerative diseases are a class of conditions characterized by deteriorating neurons and accumulated plaque in blocking the neuro transmitters of the brain and spinal cords in performance of normal functions.

According to the statistic, approximately, 5 million Americans suffer from Alzheimer's disease, 1 million from Parkinson's and 400,000 from multiple sclerosis (MS) today, inducing overwhelming social, economic and health care burden on society.

The differentiation of green tea bioactive constituents in risk of neuro-degenerative diseases was found to associate to numbers of mechanism through many different aspects.

The investigation of green tea bioactive epigallocatechin-gallate (EGCG) activities in lipopolysaccharide- (LPS-) mediated systemic inflammation in induction of neurodegenerative diseases suggested that application of green tea chemical constituent demonstrated a significant effect in ameliorated LPS induced expression of proinflammatory cytokines of tumor necrosis factor alphaTNF-α, a cell signalling protein involved in systemic inflammation in the acute phase of infection, and interleukin 1 beta (IL1β), an cytokine with function in the regulation of immune and inflammatory responses to infections or sterile insults and interleukin 6 (IL-6) involved in inflammation and infection responses, particularly, in the inhibition of the expressions of inflammatory cytokines in the mononuclear blood cells (PBMCs), consisting lymphocytes (T cells, B cells, NK cells) with function to clear away of debris in the infection site.

The activation of inflammatory cytokines expression caused by lipopolysaccharide- (LPS) injection can trigger neurotoxicity, leading to neurons brains progressive degeneration, resulting in elevated risk of neuro degenerative diseases.

Application of  green tea bioactive epigallocatechin-gallate (EGCG) was found not only inhibited LPS in precipitation of toxicity in resolved inflammation and mediated neuroprotection but also exerted anti toxicity through its antioxidant activity in decreased expression of reactive oxygen species in triggered brain cell apoptosis.

Interleukin 6 (IL-6) acts as both pro-inflammatory cytokines and an anti-inflammatory mytokines with function involved inflammation responses at sites of acute and chronic infection.

Further analysis of green tea Epigallo-catechin-3-gallate (EGCG) in the aspect of ROS in risk of neuro-degeneration in the dentate gyrus, part of the hippocampus and/or hippocampal formation of C57Bl/6 mice, suggested that the application promoted neural precursor cell, (a partially differentiated cell) proliferation, without changes at the level of immature and mature new neurons.

Interestingly, in adult hippocampal neurogenesis in male Balb/C mice, injection of green tea bioactive compounds in different doses also expressed a strong implication of increased cells survival without affecting cell proliferation but decreasing apoptotic cells.

The increased production of neuro precursor cell in stimulated neuro generation and increased cell survival from green tea was attributed to the green tea antioxidants acted as free radical scavengers to ameliorate chain reaction stimulated by reactive oxygen species (ROS).

Further more, green tea treatment was found to promote production of more elaborated dendritic (structures on the neuron that receive electrical messages) trees in young DCX-positive neurons with function in acquisition of spatial learning, as well as reversal learning, but not the retrieval of stored long-term memories.

Implication of green tea bio compounds EGCG also significantly increased net growth and development of nervous tissue in the adult hippocampus and hippocampal levels of phospho-Akt.in regulated multiple cellular processes, including glucose metabolism, apoptosis, cell proliferation, transcription and cell migration by re-establishing the function of PI3K in intracellular signaling pathway.

Dr. Neha Atulkumar Singh, the lead author in the article of "Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)",said, "there is a need to identify a class of drug capable of reversing neural damage and preventing further neural death" and "assesses the reliability of the neuroprotective benefits of epigallocatechin-gallate (EGCG) by shedding light on their biological, pharmacological, antioxidant and metal chelation properties, with emphasis on their ability to invoke a range of cellular mechanisms in the brain".

Taken together, green bioactive compound, EGCG may represent a potent and useful neuroprotective agent for inflammation-mediated neurological disorders and be considered as useful principle in modulated brain plasticity.

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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(2) Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG).
Singh NA1, Mandal AK2, Khan ZA3.(PubMed)

(*) Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity by Liu JB1, Zhou L1, Wang YZ2, Wang X2, Zhou Y2, Ho WZ3, Li JL2.(PubMed)

(*) Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro by Ortiz-López L1, Márquez-Valadez B2, Gómez-Sánchez A1, Silva-Lucero MD3, Torres-Pérez M1, Téllez-Ballesteros RI1, Ichwan M4, Meraz-Ríos MA5, Kempermann G6, Ramírez-Rodríguez GB7.(PubMed)