Food therapy: Chickpeas Lectin in reduced Risk and Treatment of Oral cancer

Kyle J. Norton


Ckickpeas lectin may have a profound effect in ameliorated risk and treatment of oral cancer, some scientists suggested.

Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to Middle East.

Oral cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the mouth region. At the later stage, the cancerous cell may travel a distance away from the original site to infect healthy tissues and organs.

Investigation of the process of chickpea lectin in reduced oral cell proliferation and tumor expansion
may involve expression of several aspects and mechanism.

According to the All India Institute of Medical Sciences, chickpeas reduced the cell proliferation of human oral carcinoma cells at the concentration of 37.5 μg/mL (IC50) and no toxic effect.

Further analysis, chickpeas anti cancer activity probably is a result the pro apoptotic effect induced by  phychemical agent lectin found abundantly in the legume.

Lectin are types of protein with important function of binding to cell membranes and influence cell-cell interaction.

In oral cancer cell line, injection of lectin showed a significant effect in inhibition of the p38α MAP kinase activated under cellular stresses as well as in response to inflammatory cytokines and involved function in the control of many other aspects of the physiology of the cell, such as control of cell cycle or cytoskeleton remodelling,.. for cell survival of the cancer in presence of substrate (ATP). 

By blocking the physiological expression of cancer cell, lectin reduced the cell proliferation and subsequently, shrinking the cancer site.

Further more, plytochemical lectin isolated from chickpeas also demonstrated a binding affinity with p38α in regulated the production of certain inflammatory cytokines which may have certain effect in induction of cancer growth.

The kinase p38α MAPK (p38α) plays a pivotal role in many biological processes including to protect cell in responses to inflammation and injury,

Specifically, in the influence of the production of inflammatory cytokines by p38α, lectin regulated the potent pro-inflammatory cytokine produced by cells of the innate immune system IL-1β in induction of tumor growth and metastasis in cells under prolong period of inflammation. According to general belief, many cancers have found to arise from sites of infection, chronic irritation and inflammation.

In tumor necrosis factor alpha TNF-α, application of chemical lectin to oral cancer site suppressed the inflammatory expression of the protein in induced cell survival and proliferation and promoted the pro apoptotic function of TNF-α in program of cell death and cell cycle arrest.

Tumor necrosis factor alpha TNF-α, is cell signal protein with function in induced inflammation in the acute phrase of injure and in numbers of cellular process, including cell survival, proliferation, differentiation, and death.

Importantly, the binding of kinase p38α MAPK also activated the function of IL-6, in inhibited the factors in induced production of inflammatory cytokines which have been found to have a negative impact in oral cell oncogenesis and enhanced the expression of boosting T cell trafficking to to tumor sites to induced cytotoxic effect to cause apoptosis.

IL-6, an interleukin with duo functions in both a pro-inflammatory cytokines and an anti-inflammatory myokines,

Taken together, chickpea lectin may have a therapeutically potential in reduced risk and considered as an adjunct therapy used combination with standard chemo-drugs for treatment of oral cancer

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antifungal and antiproliferative protein from Cicer arietinum: a bioactive compound against emerging pathogens by Kumar S1, Kapoor V2, Gill K1, Singh K1, Xess I3, Das SN2, Dey S1(PubMed)
(2) Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells by Shetty P1,2, Bargale A3,4, Patil BR5, Mohan R6, Dinesh US7, Vishwanatha JK8, Gai PB9, Patil VS3,4, Amsavardani TS10.(PubMed)
(3) Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms by Ochoa-Alvarez JA1, Krishnan H1, Pastorino JG1, Nevel E1, Kephart D1, Lee JJ1, Retzbach EP1, Shen Y1, Fatahzadeh M2, Baredes S3, Kalyoussef E3, Honma M4, Adelson ME5, Kaneko MK6, Kato Y6, Young MA1, Deluca-Rapone L1, Shienbaum AJ1, Yin K1, Jensen LD7, Goldberg GS1.(PubMed)

Food Therapy: Chick pea Pulses and Fibers in Reduced Risk of Metabolic Syndrome

Kyle J. Norton

Chickpea may have a profound effect in activated gut microbiota host energy homeostasis in modulated risk of metabolic syndrome, some studies suggested.

Garbanzo bean also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to Middle East.

Metabolic syndrome is a set of conditions, including high blood pressure and blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels which may contribute to the onset of cardiovascular disease and diabetes.

The effect of chickpea in reduced risk of metabolic syndrome has been investigated extensively through numbers of aspect and mechanism.

α-galactooligosaccharides (α-GOS) isolated from fermentable soluble fibers extracted of chickpea on high-fat-diet (HFD)-induced metabolic syndrome and gut bacterial dysbiosis in animal model, displayed a significant improvement of parameters which have a direct influence to the initiate risk of CVD, including deceased levels of blood glucose, total cholesterol, triglyceride, glycated serum protein, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of mice in compared to control after 4 weeks of experiment.

Injection of α-galactooligosaccharides (α-GOS) showed a restrictive activity in reduced high-fat-diet (HFD)-induced metabolic syndrome in inhibited the content of all bacteria, such as Bacteroides in breaking down food and producing valuable nutrients and energy that the body needs and Lactobacillus with function in glucose metabolism and protect against over growth of pathogens in the digestive tract.

These illustration indicated that α-galactooligosaccharides (α-GOS) have a potential used as a probiotic to improve digestive health by balancing the levels of gut bacteria through colonic fermentation.

Furthermore, the extract also induced the production of short-chain fatty acids such as propionic acid with function in reduced acidity and butyric acids with function in reduced inflammation and improve overall gastrointestinal health through colonic bacterial fermentation.

Short-chain fatty acids has been extensively promoted as prebiotics and probiotics with an aimed at improving colonic and systemic health.

The finding information suggested that α-galactooligosaccharides (α-GOS) isolated from fermentable soluble fibers extracted of chickpea may affect the metabolic disorders and gut bacterial ecosystem in a positive way.

Additionally, 14 days of 2 single-center, double-blind, randomized, placebo-controlled trials, 88 overweight adults [50% men and 50% women; 18-60 y old; body mass index (in kg/m(2)): 25-28] were supplemented for 14 d with tea contained α-GOSs with different α-GOS dosages (6, 12, or 18 g α-GOSs/d), formulas (12 g α-GOSs/d with >80% of molecules with a degree of polymerization of 2, 3, or 4), or a control substance (glucose syrup), also suggested that regardless to the composition, tea contained α-GOSs treatment group demonstrated a significant in reduced appetite, reduced energy intake during lunch and dinner in compared to control.

In other word, injection of α-GOSs daily and regularly may have a long-term effect in induced weight loss and mitigated metabolic disorders.

Similarly, the investigation of the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils), in compared with counselling to reduce energy intake by 2093 kJ/d (500 kcal/d), on risk factors of the MetSyn in two groups (nineteen and twenty-one subjects, respectively) of overweight or obese (mean BMI 32·8 kg/m2) adults
2017], also found that at the end of the experiment, both diets expressed a reductions in energy intake, waist circumference, systolic blood pressure, glycosylated Hb (HbA1c) and glucose AUC and homeostasis model of insulin resistance (HOMA-IR) following a 75 g oral glucose load at weeks 1 and 8 with levels of HDL and C-peptide increased by 4·5 and 12·3 %, respectively in compared to decreased by 0·8 and 7·6 %, respectively, in the energy-restricted group.

C-peptide is a proinsulin molecule produced by the beta cells in the pancreas.

Interestingly, insulin area under curve was found to decrease in both females and males on the energy-restricted diet by 24·2 and 4·8 %, respectively, but on the pulse diet it decreased by 13·9 % in females and increased by 27·3 % in males.

After taking into account of other con founder, Dr.Mollard RC, the lead author said, "frequent consumption of pulses,...reduced risk factors of the metabolic syndrome and these effects were equivalent, and in some instances stronger, than counselling for dietary energy reduction".

Taken together, the information findings, suggested that chick pea with abundant fibers with direct effect in improved gut health and reduced high blood pressure, high blood sugar, abnormal cholesterol or triglyceride levels and promoted weigh loss through decrease appetite may be considered as a function food in ameliorated risk of metabolic syndrome, thus lowering the risk of heart disease, stroke and diabetes.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effects of α-Galactooligosaccharides from Chickpeas on High-Fat-Diet-Induced Metabolic Syndrome in Mice by Dai Z1, Lyu W2, Xie M1, Yuan Q1, Ye H1, Hu B1, Zhou L1, Zeng X1.(PubMed)
(2) Regular consumption of pulses for 8 weeks reduces metabolic syndrome risk factors in overweight and obese adults by Mollard RC1, Luhovyy BL, Panahi S, Nunez M, Hanley A, Anderson GH.(PubMed)
(3) α-Galacto-oligosaccharides Dose-Dependently Reduce Appetite and Decrease Inflammation in Overweight Adults by Morel FB1, Dai Q2, Ni J3, Thomas D4, Parnet P5, Fança-Berthon P6.(PubMed)

Alternative Therapy, Yoga, an Integrated Form of Physical Exercise in Ameliorated Psychological Health in Women with Stillbirth

Kyle J. Norton 

Yoga may be used as integrated form of intervention in improved mental and physical health of  women who lost their babies due to stillbirth, some studies suggested.

Stillbirth is one of the tragic event to the mother characterized by the the death or loss of a baby before or during delivery.

Yoga, the ancient practice for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In the study to evaluate women in ages 19 and 45 experienced stillbirth within one year of the study, through online survey related to 1) pregnancy and family information (i.e., time since stillbirth, weight gain during pregnancy, number of other children) 2) physical activity participation, 3) depressive symptomatology, and 4) demographics, researchers found that over 88% reported of depression with score of >10 on depression scale and 23% stillbirth mothers who participated yoga  practice displayed an improvement of greater than 58% in reduction in depression.

In compared to control, decreased symptoms of depression also were observed in the group engaging to yoga exercise.

The findings indicated that yoga practice may serve as an unique opportunity to help women to cope with the multiple mental sequelae after stillbirth.

Additionally, in the concern of increased risk of post-traumatic stress disorder (PTSD) and depressive symptoms in women who experience stillbirth, researchers at the Arizona State University conducted a study to investigate whether yoga as a strategy can help to cope with PTSD symptoms of  women who have experienced the death of their baby. Out of 26 women in each group completed randomly assigned to either > 3 wks of yoga, or < 3 wks of yoga) researchers found that regardless to the periods of participation, 75% of women in both groups expressed that yoga intervention was very enjoyable or enjoyable, and very helpful or helpful to cope with grief.

Truly, yoga breathing exercise induced  deep relaxation and meditation showed to induce a state of consciousness to cope with psychological stress caused by grief and unfortunate of present event by facing the loss with the positive feelings in reduced anger and increased more compassion towards the body and mind. Physically, the mental expression in the right direction in yoga intervention  eventually induced the returning of proper hormone secretion.

Karla Helbert, LPC. Therapist, Certified Yoga instructor, in the article of Yoga for Grief & Loss. recommended yoga asanas and practices for the relief and release of grief opening poses such as mountain pose, sun salutation, yogic eye movements to help to "establish a ritual and energize the body and mind", "counteract feelings of depletion and sadness" and "(encounter) processing thoughts and memories of traumatic grief".

In deed, women in both groups of the study also indicated a higher levels of satisfaction and perceptions

More importantly, participation of 6-week and 12-month follow-up assessments among women with a history of stillbirth (N = 22) also indicated an improvement of negative psychosocial symptoms and reduced levels of perinatal grief in four of the five facets of mindfulness.

Impressively, mindfulness-based stress reduction (MBSR) is an yoga intervention which has been found to exert a significant effect in increased functional self-insight and quality of life, improved emotional balance and coping with distress, induced decreased state and trait anxiety, depression  total mood disturbance, particularly in restored balance between affective and sensory neural networks.

Dr. Roberts LR, the led author said after taking second look of the results, " Yoga mindfulness was significant mental health needs,......... following stillbirth, (as the program) successfully addressed by a promising MBI with potential scalability and sustainability"

Taking altogether, yoga as a safe and low cost may be considered as an integrated form of physical and mental exercise used conjunction with primary treatment  in reduced psychological symptoms in women after having stillbirth.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Physical activity and depressive symptoms after stillbirth: informing future interventions by Huberty J1, Leiferman JA2, Gold KJ3,4, Rowedder L5, Cacciatore J6, McClain DB7.(PubMed)
(2) Experiences of women who participated in a beta-test for an online-streamed yoga intervention after a stillbirth by Huberty JL1, Matthews J1, Leiferman J2, Cacciatore J3.(PubMed)
(3) Mindfulness-Based Intervention for Perinatal Grief in Rural India: Improved Mental Health at 12 Months Follow-Up by Roberts LR1, Montgomery SB2.(PubMed)
(4) Mindfulness-based Intervention for Perinatal Grief after Stillbirth in Rural India by Lisa R. Roberts, DrPH, MSN and Susanne B. Montgomery, PhD, MPH(PubMed)

Food Therapy: Chickpeas Isoflavones Genistein In Reduced Risk and Treatment of Prostate Cancer

Kyle J. Norton


Chickpeas with abundant isoflavones genistein may have a therapeutic and profound effect in reduced risk and treatment of prostate cancer, some scientists suggested.

Garbanzo bean also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to Middle East.

Prostate cancer is a medical condition characterized by cells growth uncontrollably in the prostate tissues. At the later stage, the cancerous may infect the tissues and organs distance away from the site of origin.

The investigation of the effects of isoflavone genistein isolated from chickpeas in prostate cancer risk was found to associate to various expressions and mechanisms.

Reactive oxygen species ROS was studied intensively for the duo effects in inhibited cancer development and induced cancer cell apoptosis through cytotoxicty.

On one hand, over expression of ROS with low antioxidant levels may cause cellular damage and induce alternation of DNA transcript being transmitted by mRNA through a complex passage to initiate irregular cell growth, the early stage of cancer development.

On the other hand, over expression of ROS can cause cytotoxicity to the target cancer site in induction of cells death and apoptosis.

Isoflavone genistein isolated from chickpeas was found to exert significantly antioxidant effects on human cells, thus ameliorated oxidative damage to cellular DNA in initiation of cancer development.

Injection of isoflavone genistein to normal cell acted as free radical scavengers not only improved the antioxidants status in inhibited the ROS activity in inauguration and progression of multistage carcinogenesis but also reduced the expression of oxidative stress-response related genes.

Interestingly, such injection also enhanced the over expression ROS function in causing toxicity to cancer cells without harming the nearby healthy cells, thus increasing cancer cells degradation, subsequently in cells death.

In fact, isoflavone genistein, best known as natural tyrosine kinase inhibitor (TKIs) are a class of chemo-medicine with function in inhibited, or blocked, the enzyme tyrosine kinase in induction of apoptosis in several different types of cancers, including prostate cancer.

Further analysis of the effect of isoflavone genistein adminitration also indicated that the phytochemicals induced cancer cell apoptosis by increased expression of Bax protein in suppressed the production of pro apoptotic activity in the cancerous site.

Additionally, isoflavone genistein also demonstrated a significant effect in stimulated the p21, a potent cyclin-dependent kinase inhibitor (CKI) expression in promoted cancer cell cycle arrest.

Application of the phytochemicals also decreased anti apoptotic activities of Bcl-2 and BclXL by blocking the release of mitochondrial contents for enhanced cell division.

More importantly, in the regulation of cellular apoptosis, isoflavone genistein also activated the PARP protein and caspases enzyme with functions to programmed cell death.

Moreover, further evaluation of cancer cell apoptosis due to injection of isoflavone genistein, researchers at the Second Affiliated Hospital of Xi'an Jiaotong University postulated that in the process in induced cancer cell apoptosis, isoflavone genistein also inhibited NF-κB protein in regulated and controlled transcription of DNA, and cell survival in numbers of cancer, examined by the electrophoresis mobility shift assay (EMSA)

In fact, the expression of NF-κB protein in reduced cancer cell proliferation and site expansion was attributed to the activation of hydrogen peroxide H2O2, with function of cytotoxicity to the tumor and tumor necrosis factor (TNF-α), a cell signaling protein with function to initiate cellular apoptosis.

Taken together, isoflavones genistein may be effective in reduced risk and treatment of prostate cancer depending to some factors involving having or not having equol converting bacteria in the intestine, specific polymorphic variation in the region of the associated gene.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways by Yiwei Li, Dejuan Kong, Bin Bao, Aamir Ahmad, and Fazlul H. Sarkar(PMC)
(1) Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro by Magee PJ1, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(2) Protease inhibitors: possible anticarcinogens in edible seeds by Troll W, Wiesner R.(PubMed)
(4) Isoflavones and Prostate Cancer: A Review of Some Critical Issues by Hong-Yi Zhang,1,2 Jie Cui,3 Ye Zhang,2 Zhen-Long Wang,1 Tie Chong,1 and Zi-Ming Wang1(PMC)
(5) Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways by Yiwei Li, Dejuan Kong, Bin Bao, Aamir Ahmad, and Fazlul H. Sarkar(PMC)

24 Exceptional Health Benefits of Beet or Beet Root

By Kyle J. Norton

Beet, best known as the beetroot or garden beet  is a perennial plant with leafy stems growing to 1–2 m tall, belongings to the amaranth family,

24 Health Benefits of Beet or Beet Root
1. Beet (Beta vulgaris) and Cancers
2. Beet (Beta vulgaris) and Type 2 diabetes
3. Beet (Beta vulgaris) and Hypertension
4. Beet (Beta vulgaris) as antioxidants
5. Beet (Beta vulgaris) and Cardiovascular diseases
6. Food Therapy: Beet Juice, the Best Beverage for Reduced Risk and Treatment of Breast Cancer
7. Food Therapy: Beet, the Best in Balancing Endothelial Function
8. Food Therapy: Beet, A Potent in Attenuated Risk and Anti Skin Cancer Biomedical Whole Food
9. Food Therapy, Beet, the Potent Anti Platelet Aggregation Whole Food Medicine
10. Food Therapy: Beet, in Prevention and Treatment of Colon Cancer
11. Food Therapy: Beet, a functional Food in Reduced Risk and Treatment of Parkinson's disease(PD)
12. Food Therapy: Beet, The Best Anti Liver Cancer Natural Functional Food
13. Food Therapy: Beet, the Best functional Food in Exhibited Hepatoprotective Effects
14. Food Therapy: Whole food Beet or Beet Juice In Promotion of Brain Health
15.***** Foot Therapy: Beet, The Best Anti Hypertension Functional Food
16. Food Therapy: Beet or Dietary Nitrate-rich Beetroot Juice in Reduced Risk of Hyperlipidemia
17. Food Therapy: Beet, The Best in Prevention and Treatment of Bladder Cancer
18. Food Therapy: Beet or Beetroot, A Function Food in Reduced Risk and Treatment of Inflammatory Bowel Disease
19. Food Therapy: Beet or Beet Root, The Best Anti Inflammatory Functional Food
20. Food Therapy: Beet or Beet Root, the Function Food in Prevention and Treatment of Prostate Cancer
21. Food Therapy: Beet or Beet Root, The Best in Ameliorated Oxidative Stress
22. Dietary Nitrate-Rich Beetroot Juice Improved Vascular Function In Reduced Risk of Heart Disease
22. Food Therapy: Beet Juice May be Potent Function Foods For Reduced Risk and Treatment of Pharynx Cancer
23. Food Therapy: Beet, The Best anti inflammatory functional Food
24. Food Therapy: Beet, Reduces Risk of Insulin Resistance and Early Onset of Diabetes

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Food Therapy: Beet, Reduces Risk of Insulin Resistance and Early Onset of Diabetes

Kyle J. Norton


Beet juice containing phytochemicals may alter postprandial glucose and insulin responses in prediabetics, some scientists postulated.

Insulin resistance, a condition of not providing enough insulin to counter the rise of blood glucose is considered as the early progression of onset of diabetes.

Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family,

Investigation of the efficacy of beet in ameliorated risk of insulin resistance may be associated different aspects involved numbers of mechanisms.

In a total of sixteen healthy individuals recruited, with consumed test meals in a controlled single-blind cross-over design, intake of beet juice showed a remarkable in countering the glucose uptake of glucose.

Tested subject reveled a significant lowering of the postprandial insulin response in the early phase and a significantly lower glucose response in the 0–30 min phase in compared to control fed with control beverage matched for macronutrient content (MCON).

Further analysis indicated that beet juice attenuated rise of glucose in the blood stream may be attributed to constituent of betacyanin betalain pigments which have been found to process anti glucose uptake and insulin resistance in patients with diabetes and other metabolic diseases and function of phytochemical polyphenols in stimulated insulin secretion and reduced hepatic glucose output by inhibited α-amylase, α-glucosidase and glucose absorption in the intestine.

α-Amylase is a protein enzyme having a function to convert hydrolysis of starch into sugars.
α-glucosidase is glucosidase in the small intestine with function to break down starch and disaccharides to sugars.

Additionally, in the homeostasis model assessment-insulin resistance index, dietary nitrate from beet juice also showed a lower insulin resistance in test subjects in compared to control through regulation of glucose homeostasis and insulin signaling pathway, improvement of insulin resistance and lipid homeostasis, inflammation, and endothelial function.

Dr. Peter C, the lead researcher said, "Betalains, polyphenols and dietary nitrate found in the beetroot juice may each contribute to the observed differences in the postprandial insulin concentration".

Interestingly, in comparison the effect of ingredients of combined 100 ml black tea, beetroot juice or control (water) in 16 obese, insulin-resistant males, beetroot juice plus black tea and beet juice treated groups exhibited a decreased postprandial peripheral vascular resistance (VR) in resistance vessels, but lesser than black tea, in compared to other groups.

According to further examination, the efficacy of beet juice and black tea expressed a significant in attenuated insulin resistance was attributed to increased postprandial blood flow in induced glucose disposal and decreased postprandial insulin response by 29 %..

More profoundly, in standardized breakfasts with or without beet-fibre given, in random order, to non-insulin-dependent diabetics study, beet fiber intake individuals expressed a strong effect in rate of glucose decrease after the meal.with blood glucose levels monitored continuously and hormonal responses determined at regular intervals for 3 hr.

Both tested subjects did not exert notable differences with regard to the plasma levels of insulin, C-peptide or glucagon in regulated levels of blood glucose,

C-peptide is a substance involved proinsulin molecule produced by the beta cells in the pancreas.

According to the study, the over expression of levels of somatostatin, a growth hormone–inhibiting hormone induced by beet-fibre intake.may contribute to a potential effect in diminished glycemic response through reduced glucose absorption and a delayed gastrointestinal transit time.

The collective findings may provide a footage of using beet juice as a functional food in ameliorated risk of insulin resistance and prevented early onset of diabetes.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteer by Peter C. Wootton-Beard,1 Kirsten Brandt,2 David Fell,3 Sarah Warner,1,2 and Lisa Ryan1,4,*(PMC)
(2) Impact of flavonoid-rich black tea and beetroot juice on postprandial peripheral vascular resistance and glucose homeostasis in obese, insulin-resistant men: a randomized controlled trial by Fuchs D1, Nyakayiru J2, Draijer R1, Mulder TP1, Hopman MT2, Eijsvogels TM2, Thijssen DH3.(PubMed)
(3) Reduced glycemic response to beet-fibre meal in non-insulin-dependent diabetics and its relation to plasma levels of pancreatic and gastrointestinal hormones by Hagander B, Asp NG, Efendić S, Nilsson-Ehle P, Lungquist I, Scherstén B.(PubMed)
(4) Purified Betacyanins from Hylocereus undatus Peel Ameliorate Obesity and Insulin Resistance in High-Fat-Diet-Fed Mice by Song H1, Chu Q1, Xu D1, Xu Y1, Zheng X1.(PubMed)
(5) Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications by Bahadoran Z1, Ghasemi A2, Mirmiran P3, Azizi F4, Hadaegh F5.(PubMed)

Food Therapy: Beet, The Best anti inflammatory functional Food

Kyle J. Norton

Intake of beet juice may have a reduced effect of inflammation through suppressing production of pro inflammatory cytokines produced by immunity.

Inflammation is the reaction of immune system in protected our body against foreign invasion cause of infection or tissues damage.

Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family,

Intake of raw beet juice (RBJ) and cooked beet (CB) on BP of hypertensive subjects, showed a significant improvement of inflammation through regulating the cell signal protein in initiation of systemic inflammation involved in acute phase of inflammatory cytokine tumor necrosis factor alpha (TNF-α) and reducing high-sensitivity level of C-reactive protein (hs-CRP) which have a major effect in the onset of cardiovascular risk in both tested groups.

Although the reduced blood pressure is not sustainable in tested subjects after creasing intake of raw beet juice (RBJ) and cooked beet (CB), the improvement of endothelial function as a result of the presence of nitric oxide and systemic inflammation during the test are remarkable.

Endothelial dysfunction is a major risk factor of cardiovascular disease and precedes the development of atherosclerosis.

In muscle damage following a marathon of 30 recreationally active males, using a double blind, independent group design with doses of beetroot juice (H-BT; 250 ml), a lower dose of beetroot juice (L-BT; 125 ml), or an isocaloric placebo (PLA; 250 ml) immediately (×3 servings), oral administered beet juice groups, showed a faster recovery of muscle damage at 48 hours in compared control.

Further analysis, application of beetroot juice in any dose enhanced over expression of antioxidants induced recover of muscle damage not only was attributed to the juice function in reduced high-sensitivity level of C-reactive protein (hs-CRP) but also increased modulation of enzyme creatine kinase (CK) responsible in expression by various tissues and cell types during muscle damage.

The antioxidant effects of beet juice also displayed a significant activity in reduced gene interleukin-6 (IL-6) secreted by T cells and macrophages in production of pro inflammatory cytokine to induce the acute phase of inflammation caused by muscle damage and exhibited anti inflammatory mytokines in fighting against infection.

Additionally, administration of beetroot juice inhibited the release of neutrophils and regulated gene interleukin-8 (IL-8), a chemoattractant cytokine produced by a variety of tissue and blood cells in expression of inflammation in the site of damage.

Neutrophils is a type of immune cells released to site of infection by immunity. Over expression of  neutrophils normally are an indication of acute infection.

Taking altogether, beet juice and products may have a remarkable effect in reduced risk of over inflammatory expression of immune system when come to muscle damage and infection caused by microorganisms.

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Author biography

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Improvement of hypertension, endothelial function and systemic inflammation following short-term supplementation with red beet (Beta vulgaris L.) juice: a randomized crossover pilot study by Asgary S1, Afshani MR2, Sahebkar A3,4, Keshvari M1, Taheri M5, Jahanian E6, Rafieian-Kopaei M7, Malekian F8, Sarrafzadegan N1.(PubMed)
(2) The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise by Clifford T1, Bell O2, West DJ2, Howatson G2,3, Stevenson EJ2.(PubMed)