Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Friday, 11 August 2017

The Best Diet Suggestions to Healthy Life and Longevity for A Serve Chronic Ill Patient

2. High vegetable and fruit intake may reduce the risk of non-Hodgkin lymphoma (NHL) as vegetables and fruit are rich in antioxidants to target the immune system and lymphoma
(https://www.ncbi.nlm.nih.gov/pubmed/19423521)

3. The risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR=0.49, 95% CI 0.23-1.02).
(https://www.ncbi.nlm.nih.gov/pubmed/17443415)

Fruits suggestions
1. Avocado( check the health benefits ( https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-avocado.html)

2. Blue or black berry
(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-blueberries.html)

3. Strawberries(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-aarden-strawberries.html)

4 Orange(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-oranges-citrus.html)

5. Pineapple(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-pineapple-ananas.html)

6. Apricot(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-apricot-prunus.html)

7. Apple(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-fruits-apple-malus.html)

Beverages suggestion
1, Black Tea, Tea saponin can markedly inhibit the proliferation and invasiveness of T-lymphoma (EL4) cells, possibly due to TNF-α- and NF-κB-mediated regulation of MAPK signaling pathway(https://www.ncbi.nlm.nih.gov/pubmed/24754510)(https://www.ncbi.nlm.nih.gov/pubmed/10942245)

2. Coffee with dairy only
A minor influence of coffee on the frequency of apoptotic cells induced by the test compounds, rendering an increase in sensitivity for apoptosis as a reason for the reduced genomic damage an unlikely or at least incomplete explanation.( https://www.ncbi.nlm.nih.gov/pubmed/15242187)

3. Water

White meats suggestion
1. Turkey
For a source of CLAs are the only natural fatty acids accepted by the National Academy of Sciences of USA as exhibiting consistent antitumor properties (https://www.ncbi.nlm.nih.gov/pubmed/14498991) and tryptophan for better sleep (http://www.ncbi.nlm.nih.gov/pubmed/3090582)

2. Chicken breast
Source of nutrient 14% of total dietary energy, 37% of protein, 13% to 32% of selected B vitamins and iron, 20% of fat, and 34% of cholesterol) https://www.ncbi.nlm.nih.gov/pubmed/1552132)

3. Deep sea fish
With same source of nutrients with plenty of omega-3 fatty acids with a lot of health benefit (https://kylejnorton.blogspot.ca/2013/11/phytochemicals-in-foods-19-health.html)

10% Others
1. Potatoes (https://kylejnorton.blogspot.ca/2013/11/healthy-foods-potatoes-solanum.html)

2. Yam(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-yams-dioscorea.html)

3. Brown Rice(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-whole-grain-brown-rice-or.html)

4. Whole Gain Cereal(https://www.ncbi.nlm.nih.gov/pubmed/27301975) and (https://www.ncbi.nlm.nih.gov/pubmed/26062574)

5. Nuts and seeds
Almonds (Prunus Dulcis)(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-nuts-seeds-almonds-prunus.html)

Walnuts (Juglans).(https://kylejnorton.blogspot.ca/2013/11/healthy-foods-nuts-seeds-walnuts-juglans.html)

You can also substitute these, excepted nuts and seeds with whole gain breads.

Moderate exercise suggestion
Regular walking about 20-40 minutes daily at your own pace to improved blood circulation, digestive absorption and immune system(https://kylejnorton.blogspot.ca/p/blog-page_31.html)

Cooking methods:
Steam and boiling vegetables over raw, boiling may reduce nutrients but does not cause problem to long term intakers.
Prefer steam or boiling in meat to reduced risk of harmful chemical and increased free radical induced risk of cancer and weakened immune expression
Topical black pepper and virgin olive oil right after steam and boiling with a little salt for taste.

Other cooking methods may induce production of cancerous chemicals and free radical expression in domino’s effects(reduced antioxidant levels and promoted chronic diseases, including cancers

Not canned foods, please
(Most of them contain some kinds of harmful chemicals for preservation).

Please make sure you talk to a dietitian before implementing. Hope you well and good luck.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Food Therapy: Cruciferous Vegetable- The Best Whole Food Medicine in Anti Inflammatory Effects

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Intake of cruciferous vegetable may be inversely correlated with circulating of proinflammatory levels of in women.

In a total of 1,005 middle-aged Chinese women study, consumption of cruciferous vegetable regularly is associated to lower circulating concentrations of proinflammatory cytokins.

Proinflammatory cytokines, also known as Interleukin (IL) and tumor necrosis factor (TNF), secreted by immune system to protect out body in inducing fever, inflammation, tissue destruction, etc.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, b roccoli etc.

Further to the study, Sulforaphane (SFN) and Diallyl disulfide(DAFDs), the naturally occurring isothiocyanate found in cruciferous vegetables, in the highly metastatic B16F-10 melanoma cells exhibited the induction of apoptosis in the cancer cell line, through involvement of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin.

Dr. Pratheeshkumar P, the lead author of the study suggested, DADS induces caspase-dependent apoptosis through a induced cell death pathway in B16F-10 melanoma cells by activating...... and suppressing pro-inflammatory cytokines.

Other phytochemical found the vegetables, such as 3,3'-diindolylmethane (DIM) , a derivative of indole-3-carbinol, also expressed anti proinflammayroy effect through interleukin (IL)-1beta, IL-6 and tumor necrosis factor.

In fact, chemical compounds found in the vegetable, not only inhibited the pro infammatory cytokins in expression of chronic diseases and caners, but also involved in other aspects, such as environment airborne particulate pollutants, according to the East Campus - Laurentian University.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women by Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G.(PubMed)
(2) Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells by Hamsa TP1, Thejass P, Kuttan G.(PubMed)
(3) The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis by Lin CH1, Chen PS, Kuo SC, Huang LJ, Gean PW, Chiu TH.(PubMed)
(4) Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice by Kim EJ1, Shin M, Park H, Hong JE, Shin HK, Kim J, Kwon DY, Park JH.(PubMed)
(5) Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract by Ritz SA1, Wan J, Diaz-Sanchez D.(PubMed)

Herbal Therapy: Alfalfa, the Neuroprotective Natural Whole Food

Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.

Neuroprotection is the action to preserve neuronal structure and/or function of the brain, particular in delay of neurodegenatve diseases and enhanced integrity of neurons.

According to the L.R. Institute of Pharmacy, methanol extract of Medicago sativa (MS) induced neuroprotective effect through antioxidant and anti-inflammatory activities against ischemia and reperfusion-induced cerebral injury in mice as free radicals expression are elevated with deletion of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD) and total tissue sulfhydryl (T-SH) groups.

Indeed, mice treated with Medicago sativa (MS) exhibited significantly scavenged free radicals activity against a stable radical 1,1-diphenyl-2-picrylhydrazyl and O(•-) (2) and also inhibited XD/XO conversion and resultant O(•-) (2) production.

Dr. Bora KS, the lead researchers said, " treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity".

Further more, in the review of 117 references compiled from major databases as Chemical Abstracts, Science Direct, SciFinder, PubMed, Dr. Dukes Phytochemical and Ethnobotany, CIMER, and InteliHealth, M. sativa seems to hold great potential for various biological activities, including heat disease and neuro protective effects, attributed to some major classes of phytoconstituents, including
saponins, flavonoids, phytoestrogens, coumarins, alkaloids, amino acids, phytosterols, vitamins, digestive enzymes and terpenes.

With all the available scientific literature indicated above, alfalfa may attract the attention of natural product researchers to focus on the unexplored therapeutic potential of M. sativa, particular in neuro protective area.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult by Bora KS1, Sharma A.(PubMed)
(2) Phytochemical and pharmacological potential of Medicago sativa: a review by Bora KS1, Sharma A.(PubMed)

Herbal Therapy: Green Tea Reduce Symptoms Expression and Complications of Rheumatoid Arthritis

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Green tea exhibited anti inflammatory effect in reduced symptoms and progression of
Rheumatoid Arthritis, a renowned institute study suggested

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body after the ages of 40 and causing diminished quality of life of many elder.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including dizziness, low energy, weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the joint study lead by Washington State University College of Pharmacy, green tea (EGCG, EGC, and EC) showed to ameliorate the expression of pro-inflammatory mediators including (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs), through the effects of its phytochemical compounds of EGCG and EGC antioxidant activities.

Dr. Fechtner S, the lead researcher said," EGCG is the most effective catechin at inhibiting downstream inflammatory signaling, its effectiveness could be hindered by the presence of (epicatechin) EC".

In the investigation of the anti-inflammatory activity of green versus black tea aqueous extract in a rat model with orally/daily distilled water as placebo, indomethacin (1.0 mg/kg body weight; a non-steroidal/anti-inflammatory drug), or tea aqueous extracts (for 28 or 14 consecutive days administrated from day 0 or 14 of arthritis induction, respectively), group treated with high dose of GTE (from day 0) significantly alleviated (P < 0.05-0.001) the progression and all complications induced by rheumatoid arthritis in compared placebo.

More importantly, Researchers also found that the expression of anti-arthritic activity of the high dose of GTE (from day 0) mediated by significantly decreasing the systemic production of pro-inflammatory cytokines and the expression of chemokine receptor-5, a protein in activated immune activities in the in synovial tissues,was comparable (P > 0.05) with that of indomethacin (12.9-53.8 vs. 9.5-48.4%, respectively).
Furthermore, the anti-arthritic potency of tea aqueous extracts was doses dependent in the order of high dose of GTE > low dose of GTE ≥ high dose of BTE > low dose of BTE.

Other study suggested that green tea extract in reduced symptoms and riak of complication probably are the result in regulating chemokine(a family of cytokines secreted by cells) production in immune reaction and chemokine receptor expression in interaction with proimflammatory cytokines of human RA synovial fibroblasts in rat adjuvant-induced arthritis (AIA).

Taking together, green tea nay be served as a functional food to reduce symptoms and risk of complication for patients with rheumatoid arthritis.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts by Fechtner S1, Singh A1, Chourasia M2, Ahmed S3.(PubMed)
(2) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(3) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)

Thursday, 10 August 2017

Herbal Therapy: Chaste Tree Berry Reduced Symptoms of Pain in Severe Primary Dysmenorrhea

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the Nenehatun Hospital, In animal models, Chaste tree berry treatment significantly reduced symptoms of severe primary dysmenorrhea in the the end of third month of therapy.

In a total of total of 60 women with severe primary dysmenorrhea and 30 healthy women (control) included in this study. 30 patients treated with ethinyl estradiol 0.03 mg/drospirenone (group 1) and another 30 treated with Fructus agni casti (group 2) during three menstrual cycles using the visual analog scale (VAS) scores, pulsatility index (PI), herbal plant treated group showed a higher mean PI and RI values in patients with severe primary dysmenorrhea in compared control groups on the first day of the first menstrual cycle (P < 0.0001) but the means of both values were significantly lower after the treatment in both groups compared to before values (P < 0.001 for both),

Additionally, researchers also found an increased uterine blood flow but no significant differences in terms of Doppler findings between group 1 and 2, as women with severe symptoms of primary dysmenorrhea exhibited normally a high impedance to blood flow in uterine arteries with a preserved cyclic pattern throughout the whole cycle.

Dr. Aksoy AN, the lead author in the study said, "The effectiveness of Fructus agni casti was similar to that of ethinyl estradiol/drospirenone in patients with primary dysmenorrhea"

Other researchers also insisted that the efficacy of Chaste tree berry in reduced pain may be associated to the antinociceptive and analgesic activities, according to the petroleum ether fraction (PEF) from the aqueous ethanol extract of Vitex negundo Linn. (Verbenaceae) seeds injection into mice study conducted by the Second Military Medical University.

More importantly, other member of the Vitex group such as Vitex doniana extract may also have an effect in reduced uterine pain through regulating the hormone production of prostaglandins, ergometrine and oxytocin which are found to have a direct involvement of uterine muscle contractions.

Taking together, Chaste tree berry may be a potential herbal medicine for treatment of painful symptoms in women with severe primary dysmenorrhea involved many mechanisms, including the antinociceptive, analgesic, hormone regulated properties.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Evaluation of the efficacy of Fructus agni casti in women with severe primary dysmenorrhea: a prospective comparative Doppler study by Aksoy AN1, Gözükara I, Kabil Kucur S.(PubMed)
(2) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)
(3) Activity of aqueous extract of the bark of Vitex doniana on uterine muscle response to drugs by Ladeji O1, Udoh FV, Okoye ZS.(PubMed)

Wednesday, 9 August 2017

Herbal Therapy: Green Tea, The Best Functional Food In Reduced Risk and Treatment of Breast Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Green tea may be next generation of in expensive herbal medicine for reduced risk and treatment of breast cancer, a renowned institute study suggested

Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the joint study lead by the Xinyang Normal UniversityHenan, Epigallocatechin-3-gallate (EGCG), a bioactive compound in green tea inhibited risk of breast cancer through many mechanisms involving primarily in cell death and survival.

The study also insisted the efficacy of Epigallocatechin-3-gallate (EGCG) in reduced risk of breast cancer probably due to main function in induced cancer cell cycle arrest in interference of cell division.

In MDA-MB-231 breast cancer cell line, Epigallocatechin gallate isolated from green tea induced apoptosis and inhibited tumorigenesis through expression of multiple signaling pathways in breast cancer cells.

Also, EGCG decreased MDA-MB-231 cell viability and significantly downregulated the expression of β-catenin in regulated the coordination of cell–cell adhesion and gene transcription, according to Western blot analysis as patients with breast cancer is found to associate to high levels of β-catenin in breast cancer tissue than in normal tissue.

Dr. Hong OY, the lead author said, "EGCG inhibits the growth of MDA-MB-231 cells through the inactivation of the β-catenin signaling pathway. Based on these promising results, EGCG may be a potential treatment for triple negative breast cancer patients.".

In polychlorinated biphenyls (PCBs) accumulated in human breast cancer tissue induced the growth of estrogen-sensitive tumors, EGCG inhibited the early onset of breast cancer through modifying estrogenic activity against cell proliferation in a dose-dependent manner.

Furthermore, at dose of at 25 μM, EGCG also exerted antiproliferative and pro-apoptotic action in the activation of ERβ receptor.

With all the information collected above, green tea, containing rich sources of anti malignant and non malignant tumors phytochemicals, may be considered as a functional food in reduced risk and treatment of breast cancer.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green TeaCompound Epigallocatechin-3-Gallate Against Breast Cancer by Song X1,2, Zhang M3, Chen L1, Lin Q2.(PubMed)
(2) Epigallocatechin gallate inhibits the growth of MDA-MB-231 breast cancer cells via inactivation of the β-catenin signaling pathway by Hong OY1, Noh EM2, Jang HY1, Lee YR2, Lee BK3, Jung SH3, Kim JS1, Youn HJ3.(PubMed)
(3) Green Tea Catechin, EGCG, Suppresses PCB 102-Induced Proliferation in Estrogen-Sensitive Breast Cancer Cells by Baker KM1, Bauer AC2.(PubMed)

Herbal Therapy, Chaste Tree Berry in Reduced Risk and Treatment of Colon Cancer

Vitex agnus-castus fruit is found to process an anti irregular cell growth, the early stage of cancer development in colon, a university study suggested.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Colon cancer is a medical condition of the abnormal proliferation of cells in large intestine.

According to the Tokyo University of Pharmacy & Life Sciences, treatment with chaste tree berry induced apoptosis of cancer cells not by the presence of antioxidant but expression of anti body gene HO-1 in regulating oxidative stress.

Dr. Imai M, the lead researcher said. "Vitex treatment activates a pathway associated with HO-1 gene activation, resulting in the induction of apoptosis in COLO 201, (the colon cancer cell line)".

Additionally, in a novel strategy with biological approach for synthesis of silver nanoparticles (AgNPs), a toxic substance, using sodium para-hydroxybenzoate tetrahydrate (SPHT) isolated from Vitex negundo leaves, treatment of sodium para-hydroxybenzoate tetrahydrate (SPHT) improved the hydroxyl and carboxylic functional groups mediators in edhibited a stronger ability towards synthesis of AgNPs which indicated the apoptotic effect on human colon cancer cell lines.

The study also insisted that the extract displays a anti colon cancer activity confirmed by colorimetric assay, annexin V/Dead Cell Apoptosis and cell cycle analysis.

Furthermore, casticin, one of the major components of the fruits of chaste tree, showed a significantly induced apoptosic effect in of HT-29, HCT-116, SW480 and Caco-2 cells, reduced accumulation of reactive oxygen species (ROS) and increased the protein levels in regulation of cancer cell apoptosis and B-cell lymphoma activation of cell death of HT-29 cells, a colon cancer cell line.

Collectively, casticin also promoted Cell Death in cell division with the same mechanisms in other cancer cell lines, including HCT-116, SW480 and Caco-2 cells.

Taking together, chaste tree berry may be next therapeutic treatment for reduced risk and treatment of colon cancer, but injection of large quantity should only prescribed by related field specialists.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: a potential natural anti-cancer substance by Imai M1, Kikuchi H, Denda T, Ohyama K, Hirobe C, Toyoda H.(PubMed)
(2) Synthesis and characterization of silver nanoparticles using crystal compound of sodium para-hydroxybenzoate tetrahydrate isolated from Vitex negundo. L leaves and its apoptotic effect on human colon cancer cell lines by Durai P1, Chinnasamy A2, Gajendran B1, Ramar M1, Pappu S3, Kasivelu G4, Thirunavukkarasu A5.(PubMed)
(3) Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells by Qu L1, Liu FX1, Cao XC2, Xiao Q2, Yang X2, Ren KQ2.(PubMed)