The holistic Prevention, Management and Treatment of Dementia induced by Toxins - TCM Herbal Xiu Hui Xiang (Fennel)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.


   TCM Treatment of Dementia Induced by toxins - Shui Fei Zi or Milk thistle (Silybum marianum)

Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.5. Chinese Herbal medicine for toxins elimination
2. Xiu Hui Xiang (Fennel)
Xiu Hui Xiang, the acrid and warm herb, is also known as fennel, native to Mediterranean, used in traditional Chinese medicine as anti microbal(1232)(1233), antioxidant(1234)(1235), emmenagogue(1236), estrogenic(1244) and androgenic(1245) agents and to prevent bone loss in postmenopausal osteoporosis(1237)(1238), treat hepatic fibrosis(1239), gastro intestine disorder(1240)(1241), decrease hair thickness(1243) and increase flow of breast milk(1242) by enhancing function of liver, kidney, spleen, stomach channels(1231).

Phytoshemicals
1. Linoleic acid
2. Palmitic acid
3. Arachidic acid
4. Behenic acid
5. Quercetin
6. Phytosteryl b-fructofuranoside
7. 7-hydroxycoumarin
8. 6,7-dihydroxycoumarin
9. Oleanolic acid
10. Sitosterol
11. Fenchone
12. α-pinene
13. Limonene
14. β-Pinene
15. β-Myrcene
16. α-Phellandrene
17. P-Cymol
18. Etc.


Xiu Hui Xiang (Fennel) used in the treatment of symptoms of neurodegenerative disorder, including age-related mental problems of Alzheimer's disease(1246)) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in acetylcholinesterase inhibition(1246) and anti inflammation(1247) through suppression of the nuclear factor-kappaB activation pathway(1247) involved stress, cell signaling, free radicals, oxidized LDL activities(1248)(1249)(1250)(1251).

2.1. In anxiolytic activity
Anxiety is a condition of neurodisorder of unpleasant state of inner turmoil with fear of the presence and future, according to Diagnostic and Statistical Manual of Mental Disorders American Psychiatric Association, effecting patients with dementia, included familial Alzheimer's disease(1252) and other neuropsychiatric disorders(1254). Fennel, a medical herb used in many cultures, has shown effectively in treating anxiety, epidemiologically. In adult Swiss albino male mice, oral administration 100 and 200 mg/kg doses of fennel essential oil significantly increased percent number of entries and time spent in open arms in elevated plus maze (EPM) test(1255).


2.2. In learning and memory
Fennels, the most widely used herbal plant in the world(1256) used in traditional Iranian medicine and modern phytotherapy for memoryenhancing(1257). In Alzheimer's disease, induced a decline of cognitive abilities in mice model, fennel extract successfully ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and aging- induced memory deficits in 8 days in dose-depend manner, through increased step-down latency and acetylcholinesterase inhibition(1258).

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References
(1232) Benefit of supplements in functional dyspepsia after treatment of Helicobacter pylori. by Pellicano R1, Ribaldone DG, Saracco GM, Leone N, De Angelis C, Arrigoni A, Morello E, Sapone N, Cisarò F, Astegiano M.(PubMed)
(1233) Antimicrobial activity of plant essential oils against bacterial and fungal species involved in food poisoning and/or food decay. by Lixandru BE1, Drăcea NO, Dragomirescu CC, Drăgulescu EC, Coldea IL, Anton L, Dobre E, Rovinaru C, Codiţă I.(PubMed)
(1234) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare).by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM.(PubMed)
(1235) Assessment of free radical scavenging potential and oxidative DNA damage preventive activity of Trachyspermum ammi L. (carom) and Foeniculum vulgare Mill. (fennel) seed extracts. by Goswami N1, Chatterjee S1.(PubMed)
(1236) Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy. by Rahimi R1, Ardekani MR.(PubMed)
(1237) Potent inhibitory effect of Foeniculum vulgare Miller extract on osteoclast differentiation and ovariectomy-induced bone loss. by Kim TH1, Kim HJ, Lee SH, Kim SY.(PubMed)
(1238) Effects of Foeniculum vulgare ethanol extract on osteogenesis in human mecenchymal stem cells by Mahmoudi Z1, Soleimani M2, Saidi A1, Khamisipour G3, Azizsoltani A4.(PubMed)
(1239) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX.(PubMed)
(1240) Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells by Zaidi SF1, Muhammad JS, Shahryar S, Usmanghani K, Gilani AH, Jafri W, Sugiyama T.(PubMed)
(1241) Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. by Picon PD1, Picon RV, Costa AF, Sander GB, Amaral KM, Aboy AL, Henriques AT.(PubMed)
(1242) Fennel and anise as estrogenic agents by Albert-Puleo M.(PubMed)
(1243) The effect of fennel (Foeniculum vulgare) gel 3% in decreasing hair thickness in idiopathic mild to moderate hirsutism, A randomized placebo controlled clinical trial by Akha O1, Rabiei K2, Kashi Z1, Bahar A1, Zaeif-Khorasani E1, Kosaryan M3, Saeedi M4, Ebrahimzadeh MA5, Emadian O6.(PubMed)
(1244)
(1245) Antihirsutism activity of Fennel (fruits of Foeniculum vulgare) extract. A double-blind placebo controlled study. by Javidnia K1, Dastgheib L, Mohammadi Samani S, Nasiri A.(PubMed)(1246) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn. by Joshi H1, Parle M(PubMed)
(1247) Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning by Aggarwal BB1, Shishodia S.(PubMed)
(1248) Introduction to NF-B: players, pathways, perspectives by T D Gilmore1(Oncogene)
(1249) The NF-κB regulatory network by Allan R. Brasier(Springer link)
(1250) The Rel/NF-kappaB signal transduction pathway: introduction. by Gilmore TD1.(PubMed)
(1251) Integrating cell-signalling pathways with NF-κB and IKK function by Neil D. Perkins(Nature view)

(1252) Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network by Ringman JM1, Liang LJ2, Zhou Y3, Vangala S2, Teng E4, Kremen S3, Wharton D3, Goate A5, Marcus DS6, Farlow M7, Ghetti B8, McDade E9, Masters CL10,Mayeux RP11, Rossor M12, Salloway S13, Schofield PR14, Cummings JL15, Buckles V6, Bateman R6, Morris JC6; Dominantly Inherited Alzheimer Network.(PubMed)
(1253) The course of neuropsychiatric symptoms in dementia: a 3-year longitudinal study. by Brodaty H1, Connors MH2, Xu J2, Woodward M3, Ames D4; PRIME study group.(PubMed)
(1254) Neuropsychiatric symptoms, APOE ε4, and the risk of incident dementia: a population-based study. by Pink A1, Stokin GB1, Bartley MM1, Roberts RO1, Sochor O1, Machulda MM1, Krell-Roesch J1, Knopman DS1, Acosta JI1, Christianson TJ1, Pankratz VS1,Mielke MM1, Petersen RC1, Geda YE2.(PubMed)
(1255) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Mesfin M, Asres K, Shibeshi W1.(PubMed)
(1256) Foeniculum vulgare Mill: a review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology by Badgujar SB1, Patel VV1, Bandivdekar AH1.(PubMed)
(1257) Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy by Rahimi R1, Ardekani MR.(PubMed)

The holistic Prevention, Management and Treatment of Dementia due to Blood Stasis -TCM Herbal Polygonum multiflorum (He shou wu)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.


   TCM Treatment of Dementia Induced by Blood Stasis -TCM Herbal  Polygonum multiflorum (He shou wu)

Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.4. Dementia due to Blood Stasis
According to Chinese medical literaure over 3000 years of history, blood stasis may be caused by spleen qi deficiency, but in most cases, it is due to heart qi deficiency cause of inability in transport nutrients to the body organs and cells, including the brain. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting or death of neurons, cognitive impairments(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842). Blood statsis induced by cold(1142), emotional disorder(1143), aging(1144),chronic illnesses and consumptive disease(1145), can overload the heart capacity, contributing to long-term hypertension(1146) due to decreased or impeded blood flow(1147) causes of hypo-perfusion in cerebral blood flow or acute focal stroke in memory-related cerebral parenchyma induced progression of cognitive decline(*).

2. Polygonum multiflorum (He shou wu)
He Shu Wu or Ye Jiao Teng or Shu Wu is also known as Fleece flower root or Fo-ti.
a. The prepared herb is astringent with some sweetness, mildly warm
b. The raw herb is bitter, sweet and neutral
used in TCM to treatment of hyperlipemia(1173), neurasthenia(1174), split personality(1174), promoted hair grown(1175) and prevent hair loss(1176) due to aging, skin rash due to inflammation(1177), etc., as it tonifies and benefits the essence and blood, expels toxins, moistens the intestines, etc. by enhancing the (The prepared herb) liver and kidney channels and (The raw herb) liver, heart and large intestine channels(1178).

Phytochemicals
1. Polygoacetophenoside
2. Chrysophanol
3. Emodin
4. Rhein
5. Emodin-6
6. Physcion
7. Chrysophanic acid
8. Anthrone
9. beta-sitosterol
10. 2,3,5,4′-tetrahydroxystibene-2O-b-D-glucoside
11. Quercetin-3-O-galactoside
12. Querctin-3-O-arabinoside
13. Lecithin
14. Etc.

2.1. In Alzheimer's disease
Polygonum multiflorum extract, significantly improved AD patients with total effective rate of 93.33% in clinical trial, according to Third XiangyaHospital(1179). In rat model, induced Alzheimer's disease by injecting Abeta 1-40, the herb exhibited improvement of learning and memory ability, through expression of the fluidity of mitochondria membrane and the activity of mitochondrial COX(1180) and ameliorated hippocampal synapses count and synaptophysin expression(1181). In cognitive deficits induced by Abeta25-35,Polygonum multiflorum water extract, also significantly ameliorated the cognitive deficits, probably due to its antioxidant properties(1182).

2.2. In Parkinson disease
Strong evidences suggested that agricultural chemicals and environment toxins, such as dithiocarbamate fungicides, impacted dopamine systems has shown to associate to the development of Parkinson's disease,(1184)(1185). In nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice model, ethanol-soluble PME (PME-I) water extracts from Polygonum multiflorum, improved locomotor activity, motor incoordination, and declines of dopamine level, probably through phytochemicals, in the ethanol-soluble fraction(1183).

2.3. In neuroprotective effects
In focal cerebral ischemia mice, hexane extracts of Polygonum multiflorum, exhibited its neuroprotective effects though significantly decreased infarct size and improved neurological and motor function, (1186) and attenuated glutamate-induced neurotoxicity in a concentration-dependent manner and prevented apoptosis of cortical neurons(1187), in HT22 hippocampal cells(1188), probably through it antioxidant activity. According to Xuanwu Hospital of Capital Medical University, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) extract from Polygonum multiflorum, also improved mitochondrial function, decreased oxidative stress and inhibited apoptosis against induced cytotoxicity in human dopaminergic neuroblastoma SH-SY5Y cells(1188).

2.4. In learning and memory
Dietary supplementation with either ethanol or water extracts of Polygonummultiflorum have shown to reduce brain pathological changes and promote learning and memory ability(1191)(1192). In male Sprague-Dawley rats, injected with beta amyloid (Aβ), tetrahydroxystilbene glucoside, an active chemical constituent of extract from Polygonum multiflorum, significantly improved the learning and memory, through protecting synaptic structure and function(1189) and learning and/or memory ability of aged rats by increasedBeta-secretase 1 (BACE1), a beta-site amyloid precursor protein cleaving enzyme 1 and decreased ADAM10 (metallopeptidase domain 10), a protein associated to the development of Alzheimer's disease(1190).

B.5. According to TCM philosophy, dementia is also to be induced by the combination/or of Kidney essence vacuity and toxin (turbid phlegm).
C.5.1. Dementia due to toxins accumulation
Toxins accumulation in internal organs disturbed the balance of immunity(1213)(1214) may cause impairment of food intake regulation(1215), exhibition of phlegm(1208)(1208)(1210), retention of fluid(1211)(1212) and blood statsis(1209) induced early the onset of dementia, in aging population with depletion of kidney-essence(1208)(1209), according to traditional Chinese medicine.

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References
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)
(1173) [Blood lipid-regulation of stilbene glycoside from polygonum multiflorum].[Article in Chinese] by Gao X1, Hu YJ, Fu LC.(PubMed)
(1174) Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice by Chan YC1, Wang MF, Chang HC.(PubMed)
(1175) In vivo hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice by Begum S1, Gu LJ, Lee MR, Li Z, Li JJ, Hossain MJ, Wang YB, Sung CK.(PubMed)
(1176) [Impact of 2, 3-dihydrocyclopentacoumarins to growth of transgenic hairy roots of Polygonum multiflorum and accumulation of stilbene glucosides].[Article in Chinese] by Liu L1, Zhou L, Zhang M, Yu R.(PubMed)
(1177) [Treatment of chronic primary glomerulopathy patients of Shen deficiency and dampness heat syndrome by yishen qingli granule combined low-dose Tripterygium wilfordii multiglycoside tablet: a clinical efficacy observation].[Article in Chinese] by Sheng MX1, Sun W2, Xing CY3, Yuan FH4, Tang SF5, Xiong PH6, Ma JP7, Zhou D2, Gao K2, Jiang Y2, Chen JH2, Mao HJ3, Mou J4, Luo YZ5, Wei MG6, Liu CX7.(PubMed)
(1178) HE SHOU WU (Complementary and Alternative Healing University)
(1179) [Effect of compound Polygonum multiflorum extract on Alzheimer's disease].[Article in Chinese] by Chen L1, Huang J, Xue L.(PubMed)
(1180) Effect of polygonum multiflorum on the fluidity of the mitochondria membrane and activity of COX in the hippocampus of rats with Abeta 1-40-induced Alzheimer's disease. by Hou DR1, Wang Y, Xue L, Tian Y, Chen K, Song Z, Yang QD.(PubMed)
(1181) Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats by Wang R1, Tang Y, Feng B, Ye C, Fang L, Zhang L, Li L.(PubMed)
(1182) Protective effect of Polygonum multiflorum Thunb on amyloid beta-peptide 25-35 induced cognitive deficits in mice by Um MY1, Choi WH, Aan JY, Kim SR, Ha TY.(PubMed)
(1183) Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice by Li X1, Matsumoto K, Murakami Y, Tezuka Y, Wu Y, Kadota S.(PubMed)
(1184) The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease by Thiruchelvam M1, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA(PubMed)
(1185) Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? by Cicchetti F1, Drouin-Ouellet J, Gross RE.(PubMed)
(1186) Hexane extracts of Polygonum multiflorum improve tissue and functional outcome following focal cerebral ischemia in mice by Lee SV1, Choi KH1, Choi YW2, Hong JW1, Baek JU1, Choi BT1, Shin HK1.(PubMed)
(1187) Hexane extract from Polygonum multiflorum attenuates glutamate-induced apoptosis in primary cultured cortical neurons by Jang JY1, Kim HN, Kim YR, Choi YW, Choi YH, Lee JH, Shin HK, Choi BT.(PubMed)
(1188) Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity by Sun FL1, Zhang L, Zhang RY, Li L.(PubMed)
(1189) Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β(₁₋₄₂)-injected rats and may be connected to synaptic changes in the hippocampus by Zhou L1, Hou Y, Yang Q, Du X, Li M, Yuan M, Zhou Z.(PubMed)
(1190) Tetrahydroxystilbene glucoside improves learning and (or) memory ability of aged rats and may be connected to the APP pathway by Hou Y1, Yang Q, Zhou L, Du X, Li M, Yuan M, Zhou Z, Li Z.(PubMed)
(1191) Beneficial effects of different Polygonum multiflorum Thunb. extracts on memory and hippocampus morphology by Chan YC1, Cheng FC, Wang MF.(PubMed)
(1192) Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice. by Chan YC1, Wang MF, Chang HC.(PubMed)
(1193) Milk thistle (Silybum marianum) for the therapy of liver disease by Flora K1, Hahn M, Rosen H, Benner K.(PubMed)
(1194) Milk thistle in liver diseases: past, present, future by Abenavoli L1, Capasso R, Milic N, Capasso F.(PubMed)
(1195) Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. by Gharagozloo M1, Javid EN, Rezaei A, Mousavizadeh K.(PubMed)
(1196) Silibinin reverses drug resistance in human small-cell lung carcinoma cells by Sadava D1, Kane SE.(PubMed)
(1197) Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer. by Forghani P1, Khorramizadeh MR, Waller EK.(PubMed)
(1198) Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells. by Fan L1, Ma Y1, Liu Y1, Zheng D2, Huang G3.(PubMed)
(1199) Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production by Gharagozloo M1, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A.(PubMed)
(1200) Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application by Wu JW1, Lin LC, Hung SC, Chi CW, Tsai TH.(PubMed)
(1201) Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. by Khoshnoodi M1, Fakhraei N, Dehpour AR.(PubMed)
(1202) Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials by Yang Z1, Zhuang L2, Lu Y1, Xu Q1, Chen X1.(PubMed)
(1203) Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial by Fried MW1, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, Doo E, Meyers CM, Reddy KR; Silymarin in NASH and C Hepatitis (SyNCH) Study Group.(PubMed)
(1204) Shui fei ji(Complementary and Alternative Healing University)
(1205) The clinical utility of milk thistle (Silybum marianum) in cirrhosis of the liver by Boerth J1, Strong KM.(PubMed)
(1206) Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production by Gharagozloo M1, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A.(PubMed)
(1207) Systematic review of the efficacy of herbal galactogogues by Mortel M1, Mehta SD.(PubMed)
(1208) Effect of reinforcing kidney-essence, removing phlegm, and promoting mental therapy on treating Alzheimer'sdisease. by Liu P1, Kong M, Liu S, Chen G, Wang P.(PubMed)
(1209) Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: a randomized, double-blind and parallel-controlled trial by Miao YC1, Tian JZ, Shi J, Mao M.(PubMed)
(1210) Effects of acupuncture on Chinese medicine syndromes of vascular dementia. by Shi GX1, Liu CZ, Guan W, Wang ZK, Wang L, Xiao C, Li ZG, Li QQ, Wang LP.(PubMed)
(1211) Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-amyloid 42: a cross-validation study against amyloid positron emission tomography by Palmqvist S1, Zetterberg H2, Blennow K2, Vestberg S3, Andreasson U2, Brooks DJ4, Owenius R5, Hägerström D6, Wollmer P7, Minthon L8, Hansson O8.(PubMed)
(1212) Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease by Lautner R1, Palmqvist S2, Mattsson N3, Andreasson U1, Wallin A1, Pålsson E1, Jakobsson J1, Herukka SK4, Owenius R5, Olsson B1, Hampel H6, Rujescu D7,Ewers M8, Landén M9, Minthon L2, Blennow K1, Zetterberg H10, Hansson O2; Alzheimer’s Disease Neuroimaging Initiative.(PubMed)
(1213) Immunity factors for two related tRNAGln targeting killer toxins distinguish cognate and non-cognate toxic subunits by Klassen R1, Kast A, Wünsche G, Paluszynski JP, Wemhoff S, Meinhardt, F. (PubMed)
(1214) Non structural protein of avian influenza A (H11N1) virus is a weaker suppressor of immune responses but capable of inducing apoptosis in host cells. by Mukherjee S1, Majumdar S, Vipat VC, Mishra AC, Chakrabarti AK.(PubMed)
(1215) The anorexia of aging in humans by Hays NP1, Roberts SB.(PubMed)

The holistic Prevention, Management and Treatment of Dementia due to Blood Stasis -TCM Herbal Safflower (Hong Hua)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.


   TCM Treatment of Dementia Induced by Blood Stasis -TCM Herbal Safflower (Hong Hua)

Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.4. Dementia due to Blood Stasis
According to Chinese medical literaure over 3000 years of history, blood stasis may be caused by spleen qi deficiency, but in most cases, it is due to heart qi deficiency cause of inability in transport nutrients to the body organs and cells, including the brain. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting or death of neurons, cognitive impairments(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842). Blood statsis induced by cold(1142), emotional disorder(1143), aging(1144),chronic illnesses and consumptive disease(1145), can overload the heart capacity, contributing to long-term hypertension(1146) due to decreased or impeded blood flow(1147) causes of hypo-perfusion in cerebral blood flow or acute focal stroke in memory-related cerebral parenchyma induced progression of cognitive decline(*).



1. Wolfberry (Gou qi)
Gou Qi, the sweet and neutral herb is also known as wolfberry, used in TCM as anti cancers(1148)(1149), antioxidative(1150)(1151) and anti aging(1156)(1157) agent and to treat back, leg, and stomach pain(1152), hypopigmentation(1154), improve vision(1153)(1154), diabetes(1155), premature aging(1156), enhance immune system(1157), lower blood lipids(1158), elevate level of testosterone(1159), simulate estrogen and anti estrogen effect through different estrogen receptor mechanisms(1160) etc., as it nourishes and tonifies Liver and Kidneys, moistens the Lungs, etc., by enhancing the functions of liver, lung and kidney channels(1161).

Phytochemicals
1. Betaine
2. β-sitosterol
3. Linoleic acid
4. Physalien
5. Cryptoxanthin
6. Atropine
7. Hyoscyamine
8. Scopoletin
9. Amino acids
10. Physalein
11. Zeaxanthin
12. Dipalmitate
13. Carotene
14. Etc.

1.1. In Alzheimer's disease(AD)
Elevated plasma homocysteine (Hcy) levels have shown to associate to increased the risk of Alzheime's disease (AD), epidemiologically and clinically. Polysaccharides, phytochemicals derived from wolfberry (LBA) not only inhibited Abeta accumulation but also reduced risk of other factors induced AD(1162). According to the University of Hong Kong, the chemical olysaccharides, also ameliorated glutamate excitotoxicity involved in many neurodegenerative diseases including Alzheimer's disease (AD)(1163). The herbal alkaline extract was found to exhibit neuroprotection, through inhibiting Abeta-peptides induced apoptosis and neuronal cell death(1164).

1.2. In neuroprotective effects
Lycium barbarum polysaccharide (LBP), on focal cerebral ischemic injury in mice model, inhibited neuronal morphological damage and attenuated the neuronal apoptosis through mitochondrial apoptosis pathway(1165). In ischemia-reperfusion-induced damage, chemical Lycium barbarum polysaccharides (LBP), reduced apoptosis and decreasednumber of viable cells in the ganglion cell layer (GCL) and inner nuclear layer (INL), through its antioxidant activity(1166), In PC12 cell, Lycium arbarum extracts inhibited neurotoxin induced Parkinson's disease-like syndrome, through increased intracellular Ca (2+) level and significantly cell viability and cellular ATP levels(1167).

1.3. In cognitive impairment
In prenatal stress-induced cognitive impairment of offspring rats, Lyciumbarbarum showed to inhibit brain oxidative mitochondrial damage andcognitive dysfunction, through its scavenged hydroxyl and superoxide radicals(1168). Kyung-Ok-Ko (KOK), a traditional herbal prescription, containing Lycium, showed to enhance neuroprotective effects in attenuation of memory impairment, probably through its anti-inflammatory activities(1169).

1.4. In learning and memory
Lycium barbarum polysaccharides, scopolamine (SCO-induced cognitive and memory deficits in rats model, ameliorated and suppressed oxidative stress in hippocampus, and neurons apoptosis(1170). On transgenic mouse model of Alzheimer's disease, Gou qi extracts at 10 mg/kg improved the performance of the learning and the memory in rieval phases of tested models, through reduced levels of Aβ(1-42) in hippocampal tissue(1171). According toKyung Hee University, Lycium chinense fruit, in trimethyltin (TMT)-induced neuronal and cognitive impairment rats model, improved learning and memory deficit in impaired learning and memory scores(1172).

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References
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)

(1142) Network-based biomarkers for cold coagulation blood stasis syndrome and the therapeutic effects of shaofu zhuyu decoction in rats by Su S1, Duan J, Cui W, Shang E, Liu P, Bai G, Guo S, Qian D, Tang Y.(PubMed)
(1143) Blood, Blood Stasis, and Blood Path Disorders by Heiner Fruehauf(Classical Chinese medicine)
(1144) Aging & Blood Stasis: A New Tcm Approach to Geriatrics = Shuai Lao Ho Yu Hsueh
by Te-Hsin Yen, Te-Hsin Yen(Good reads)
(1145) A Look at Blood Stasis by Ronald Koh DVM, MS, CVA, CVCH, CVFT. FL USA(Chi Institute)
(1146) Constructing protein-protein interaction network of hypertension with blood stasis syndrome via digital gene expression sequencing and database mining by Lian YH1, Fang MX1, Chen LG2.(PubMed)
(1147) Blood stasis syndrome of coronary heart disease: A perspective of modern medicine. by Yu G1, Wang J.(PubMed)
(1148) Characterization of Lycium barbarum polysaccharide and its effect on human hepatoma cells. by Zhang M1, Tang X, Wang F, Zhang Q, Zhang Z.(PubMed)
(1149) [Inhibition the growth of human leukemia cells by Lycium barbarum polysaccharide].[Article in Chinese] by Gan L1, Wang J, Zhang S.(PubMed)
(1150) Supercritical fluid extract of Lycium chinense Miller root inhibition of melanin production and its potential mechanisms of action. by Huang HC, Huang WY, Tsai TC, Hsieh WY, Ko WP, Chang KJ, Chang TM1.(PubMed)
(1151) Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of Lycium barbarum and Their Antioxidant Activities. by Gao K1, Ma D, Cheng Y, Tian X, Lu Y, Du X, Tang H, Chen J.(PubMed)
(1152) Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. by Oh YC1, Cho WK, Im GY, Jeong YH, Hwang YH, Liang C, Ma JY.(PubMed)
(1153) Reversal of the Caspase-Dependent Apoptotic Cytotoxicity Pathway by Taurine from Lycium barbarum (Goji Berry) in Human Retinal Pigment Epithelial Cells: Potential Benefit in Diabetic Retinopathy. by Song MK1, Roufogalis BD, Huang TH.(PubMed)(1154) Goji berry effects on macular characteristics and plasma antioxidant levels. by Bucheli P1, Vidal K, Shen L, Gu Z, Zhang C, Miller LE, Wang J.(PubMed)
(1155) Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes by Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, Lu H, Guo F, Han C, Sun G1.(PubMed)
(1156) wolfberry aging (PubMed)
(1157) An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. by Cheng J1, Zhou ZW2, Sheng HP3, He LJ4, Fan XW5, He ZX6, Sun T7, Zhang X8, Zhao RJ9, Gu L10, Cao C2, Zhou SF11.(PubMed)
(1158) Anti-obesity and hypolipidemic effects of Lycium chinense leaf powder in obese rats. by Kang MH1, Park WJ, Choi MK.(PubMed)
(1159) Antagonistic effects of Lycium barbarum polysaccharides on the impaired reproductive system of male rats induced by local subchronic exposure to 60Co-γ irradiation by Luo Q1, Cui X, Yan J, Yang M, Liu J, Jiang Y, Li J, Zhou Y.(PubMed)
(1160) Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism. by Li G1, Sepkovic DW, Bradlow HL, Telang NT, Wong GY.(PubMed)
(1161) Qi zi(Complementary and Alternative Healing University)
(1162) Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. by Ho YS1, Yu MS, Yang XF, So KF, Yuen WH, Chang RC.(PubMed)
(1163) Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons by Ho YS1, Yu MS, Yik SY, So KF, Yuen WH, Chang RC.(PubMed)
(1164) Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on beta-amyloid peptide neurotoxicity. by Ho YS1, Yu MS, Lai CS, So KF, Yuen WH, Chang RC.(PubMed)
(1165) Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice by Wang T1, Li Y2, Wang Y1, Zhou R1, Ma L3, Hao Y1, Jin S1, Du J1, Zhao C4, Sun T3, Yu J5.(PubMed)
(1166) Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage by He M1, Pan H1, Chang RC2, So KF3, Brecha NC4, Pu M1.(PubMed)
(1167) Neuroprotective effects of Lycium chinense Miller against rotenone-induced neurotoxicity in PC12 cells by Im AR1, Kim YH, Uddin MR, Chae S, Lee HW, Kim YS, Lee MY.(PubMed)
(1168) A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro by Feng Z1, Jia H, Li X, Bai Z, Liu Z, Sun L, Zhu Z, Bucheli P, Ballèvre O, Wang J, Liu J.(PubMed)
(1169) Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils by Cai M1, Shin BY, Kim DH, Kim JM, Park SJ, Park CS, Won do H, Hong ND, Kang DH, Yutaka Y, Ryu JH.(PubMed)
(1170) Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats by Chen W1, Cheng X2, Chen J3, Yi X2, Nie D4, Sun X5, Qin J2, Tian M2, Jin G2, Zhang X2.(PubMed)
(1171) The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease by Zhang Q1, DU X, Xu Y, Dang L, Xiang L, Zhang J.(PubMed)
(1172) Neuroprotective Effect of Lucium chinense Fruit on Trimethyltin-Induced Learning and Memory Deficits in the Rats by Park HJ1, Shim HS, Choi WK, Kim KS, Bae H, Shim I.(PubMed)

The holistic Prevention, Management and Treatment of Dementia Induced by Toxin - TCM Herbal Milk thistle(Shui Fei Zi)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.


   TCM Treatment of Dementia Induced by Toxin - Shui Fei Zi or Milk thistle (Silybum marianum)

Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.5. Chinese Herbal medicine for toxins elimination
1. Shui Fei Zi or Milk thistle (Silybum marianum)
Shui fei zi, the bitter and cold herb, is also known as milk thistle, native to Western Europe and northern Africa, used in traditional Chinese medicine to improve liver function(1193)(1194)(1210), promote the flow of breast milk(1207), bile secretion(1200), anti depression(1201) and anti tumors(1196)(1197)(1198), inhibit allergic effects(1195)(1199), treat hepatitis C(1202)(1203), cirrhosis(1205) and liver fibrosis(1206), by enhancing function of liver and gallbladder channels(1204)

Phytochemicals
1. Flavonoid
2. Fumaric acid
3. Silymarin
4. Isosilybin,
5. Dehydrosilybin,
6. Silydianin
7. Silychristin
8. Cinnamic acid
9. Myristic acid
10. Palmitelaidic acid
10. Arachidic acid
11. Etc.

Shui Fei Zi or Milk thistle used in the treatment and prevention ofdementia(1218) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals Silymarin and Silibinin in ameliorated amyloid pathology(1216) and oxidative stress(1216)(1217) through attenuated levels of lipid peroxidation (malondialdehyde) and antioxidant (glutathione) in the hippocampus(1217).

1.1. In Alzheimer's disease
Alzheimer disease (AD). a neurodegenerative disorders is the most prevalent diseases in the United States, in aging population(1219). Silymarin, a phytochemical found abundantly in milk thistle, in age related disorders like neurodegenerative diseases improved locomotion rate, higher response to stimuli and tolerance to stress, in C.elegans Alzheimer's Model, through delayed paralysis via enhanced resistance to oxidative stress(1220). In rat induced Alzheimer's disease model, the phytochemical also inhibited amyloid formation(1222) and suppressed amyloid protein precursor (APP) expression(1222)and reduced neurotoxicity in PC12 cells(1222) in improvement memory(1223) and learning function(1221).

1.2. In Parkinson disease
In a mouse model of Parkinson's disease, causes of mitochondrial dysfunction and selective cells death of dopaminergic neurons, silibinin, derivative of silymarin, protected mitochondria through attenuated motor deficit and dopaminergic neuronal loss(1224) and anti oxidative and anti inflammatory pathways(1225).

1.3. In neuroprotective effects
In focal cerebral ischemia, silymarin (SM), a mixture of flavonolignans extracted from the milk thistle exerted it neuroprotective effects, in upregulating the antioxidant status and lowering the apoptotic response in slowing down the progression of neurodegeneration(1226) and preventing inflammation-related neurodegenerative disease(1227) and ROS causs of oxidative damage to macromolecules in the brain(1230).

1.4. In cognitive impairment
In cognitive deficit mice model, silibinin exhibited its anti cognitive impairment effects through amelioration of decreases in dopamine and serotonin levels in the prefrontal cortex and hippocampus, (1228). In amyloid beta peptide-induced memory impairment, the chemicals also improved cognitive memory deficits through attenuated the Abeta(25-35)- accumulation of malondialdehyde and depletion of glutathione in the hippocampus(1229).

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References
(1193) Milk thistle (Silybum marianum) for the therapy of liver disease by Flora K1, Hahn M, Rosen H, Benner K.(PubMed)
(1194) Milk thistle in liver diseases: past, present, future by Abenavoli L1, Capasso R, Milic N, Capasso F.(PubMed)
(1195) Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. by Gharagozloo M1, Javid EN, Rezaei A, Mousavizadeh K.(PubMed)
(1196) Silibinin reverses drug resistance in human small-cell lung carcinoma cells by Sadava D1, Kane SE.(PubMed)
(1197) Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer. by Forghani P1, Khorramizadeh MR, Waller EK.(PubMed)
(1198) Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells. by Fan L1, Ma Y1, Liu Y1, Zheng D2, Huang G3.(PubMed)
(1199) Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production by Gharagozloo M1, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A.(PubMed)
(1200) Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application by Wu JW1, Lin LC, Hung SC, Chi CW, Tsai TH.(PubMed)
(1201) Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. by Khoshnoodi M1, Fakhraei N, Dehpour AR.(PubMed)
(1202) Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials by Yang Z1, Zhuang L2, Lu Y1, Xu Q1, Chen X1.(PubMed)
(1203) Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial by Fried MW1, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, Doo E, Meyers CM, Reddy KR; Silymarin in NASH and C Hepatitis (SyNCH) Study Group.(PubMed)
(1204) Shui fei ji(Complementary and Alternative Healing University)
(1205) The clinical utility of milk thistle (Silybum marianum) in cirrhosis of the liver by Boerth J1, Strong KM.(PubMed)
(1206) Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production by Gharagozloo M1, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A.(PubMed)
(1207) Systematic review of the efficacy of herbal galactogogues by Mortel M1, Mehta SD.(PubMed)
(1208) Effect of reinforcing kidney-essence, removing phlegm, and promoting mental therapy on treating Alzheimer'sdisease. by Liu P1, Kong M, Liu S, Chen G, Wang P.(PubMed)
(1209) Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: a randomized, double-blind and parallel-controlled trial by Miao YC1, Tian JZ, Shi J, Mao M.(PubMed)
(1210) Effects of acupuncture on Chinese medicine syndromes of vascular dementia. by Shi GX1, Liu CZ, Guan W, Wang ZK, Wang L, Xiao C, Li ZG, Li QQ, Wang LP.(PubMed)
(1211) Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-amyloid 42: a cross-validation study against amyloid positron emission tomography by Palmqvist S1, Zetterberg H2, Blennow K2, Vestberg S3, Andreasson U2, Brooks DJ4, Owenius R5, Hägerström D6, Wollmer P7, Minthon L8, Hansson O8.(PubMed)
(1212) Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease by Lautner R1, Palmqvist S2, Mattsson N3, Andreasson U1, Wallin A1, Pålsson E1, Jakobsson J1, Herukka SK4, Owenius R5, Olsson B1, Hampel H6, Rujescu D7,Ewers M8, Landén M9, Minthon L2, Blennow K1, Zetterberg H10, Hansson O2; Alzheimer’s Disease Neuroimaging Initiative.(PubMed)
(1213) Immunity factors for two related tRNAGln targeting killer toxins distinguish cognate and non-cognate toxic subunits by Klassen R1, Kast A, Wünsche G, Paluszynski JP, Wemhoff S, Meinhardt, F. (PubMed)
(1214) Non structural protein of avian influenza A (H11N1) virus is a weaker suppressor of immune responses but capable of inducing apoptosis in host cells. by Mukherjee S1, Majumdar S, Vipat VC, Mishra AC, Chakrabarti AK.(PubMed)
(1215) The anorexia of aging in humans by Hays NP1, Roberts SB.(PubMed)
(1216) Silibinin: a novel inhibitor of Aβ aggregation by Yin F1, Liu J, Ji X, Wang Y, Zidichouski J, Zhang J.(PubMed)
(1217) Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice. by Lu P1, Mamiya T, Lu LL, Mouri A, Zou L, Nagai T, Hiramatsu M, Ikejima T, Nabeshima T.(PubMed)
(1218) Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer'sdisease mouse model by Murata N1, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.(PubMed)
(1219) Is lithium a neuroprotective agent? by Vo TM1, Perry P, Ellerby M, Bohnert K.(PubMed)
(1220) Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model by Kumar J, Park KC, Awasthi A, Prasad B1.(PubMed)
(1221) Silymarin effect on amyloid-β plaque accumulation and gene expression of APP in an Alzheimer's disease rat model by Yaghmaei P1, Azarfar K, Dezfulian M, Ebrahim-Habibi A.(PubMed)
(1222) Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer'sdisease mouse model by Murata N1, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.(PubMed)
(1223) Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice by Lu P1, Mamiya T, Lu LL, Mouri A, Niwa M, Hiramatsu M, Zou LB, Nagai T, Ikejima T, Nabeshima T.(PubMed)
(1224) Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease via mitochondrial stabilization by Lee Y1, Park HR, Chun HJ, Lee J.(PubMed)
(1225) Silibinin attenuates MPP⁺-induced neurotoxicity in the substantia nigra in vivo by Jung UJ1, Jeon MT, Choi MS, Kim SR.(PubMed)
(1226) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(1227) Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation. by Hou YC1, Liou KT, Chern CM, Wang YH, Liao JF, Chang S, Chou YH, Shen YC.(PubMed)
(1228) Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment by Lu P1, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou LB, Nagai T, Yamada K, Ikejima T, Nabeshima T.(PubMed)
(1229) Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice. by Lu P1, Mamiya T, Lu LL, Mouri A, Zou L, Nagai T, Hiramatsu M, Ikejima T, Nabeshima T.(PubMed)

The holistic Prevention, Management and Treatment of Dementia due to Spleen Qi deficiency - TCM Herbal Cinnamon bark (Rou gui)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.


   TCM Treatment of Dementia Induced by Spleen Qi deficiency - TCM Herbal Cinnamon bark (Rou gui)

Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.1. Deficiency of Qi, mainly due to
B.3.3. Spleen Qi deficiency
Spleen is a vital organ, according to traditional Chinese medicine, with function in absoring nutrients and transporting them to body's organs and cells. Spleen Qi deficiency is a condition of the inability of the spleen in maximized transportation of nutrients to body organs, including the brain. Prolong period of malnutrition of brain cells may induce abnormal functions in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842).



4. Cinnamon bark (Rou gui)
Rou gui, an acrid, sweet, very hot herb, is also known as Cinnamon bark, used in TCM as anti-spasmodic(1110), antibiotic(1111), antigastric ulcers(1112), anti impotent and anti diabetic(1113)(1114) agents and to treat hepatitis(1115), flatulence(1116), weak digestion(1116), pain in solar plexus(1110), breast cancer(1117)(1118), tuberculosis(1119)(1120), etc., as it drains the liver heat, eliminates Qi accumulation, disperses nodules, reduces stagnation, etc.by enhancing the functions of heart, lung, bladder channels(1121).

Ingredients
1. Cinnamic aldehyde
2. Cinnamyl acetate
3. Eugenol
4. Aldehyde
5. Pinene
6. Coumarin
7. Cinnamyl alcohol
8. Cinnamic acid
9. Cinnzeylanol
10. Cinnzeylanine
11. Etc.

Cinnamon bark (Rou gui) used in the treatment of symptoms of neurological impairment(1108)(1109) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals, including major constituent cinnamaldehyde (CA) and epicatechin (EC)(1122) in exertion of its neuroprotective effects(1123)(1123), through anti oxidative stress(1125), anti inflammatory(1124)) activities, against β-amyloid (Aβ) accumulation(1126) induced neurotoxicity causes of Alzheimer's disease.(1126)(1127) and neurodegeneration(1128).

4.1. In Alzheimer's disease
Cinnamon, a multifaceted medicinal plant have shown to consist activities against neurological disorders, including Alzheimer's diseases(1129) by blocking and reversing tau modification and aggregation(1131)(1130) and ischemic stroke induced cell swelling(1130). In β-amyloid polypeptide (Aβ), associated to the development of Alzheimer's disease(AD) mouses model, oral administration of cinnamon extract exhibited neuroroprotective effects in enhancing the fully recover of locomotion defects and totally abolished tetrameric species of Aβ in their brain(1132). In a high fat/high fructose diet induced Alzheimer's disease(AD) symptoms, cinnamon (CN) ameliorated enzyme phosphatase and proteins tensin homolog (PTEN), tau and amyloid precursor, associated to Alzheimer's disease(AD), through improved insulin sensitivity and related changes in the brain(1133).
According to The Business and Technology Center, West Lafayette, Chinesecinnamon, is one of the tested herb with potential for prevention and treatment of early onset of Alzheimer's disease(AD)(1134).

4.2. In Parkinson's disease
In a mice model, oral administration of cinnamon (Cinnamonum verum) powder upregulaed and/or maintained the level of Parkin/DJ-1, a beneficial proteins associated to degeneration progression of Parkinson's disease(1135). through protection of dopaminergic neurons(1136). In oligomeriztion of α-synuclein (α-syn) formation associated with the symptoms of Parkinson's Disease, cinnamon extract precipitation (CEppt), inhibited oligomeric and fibrillar forms of α-syn through ameliorated aggregation of β-amyloid polypeptide(1137).

4.3. In neuroprotective effects
Oxidative stress has shown to associate to brain damage due to its high consumption of oxygen.
Cinnamon polyphenols, during oxidative stress, exhibited neuroprotective effects in glial cells by reduced overexpression of the proinflammatory factors(1138) and enhanced prosurvival proteins protein levels (sirtuin 1, 2, and 3, deacetylases) associated to glioma cells survival(1139). Cinnamaldehyde, a major chemical found in cinnamon, inhibited uncontrolled activation of microglia contributing to neuroinflammation involved in the development of neurodegenerative diseases(1140). The herbal water extract, also exerted neuro protective effect against glutamate-induced neuronal death through the inhibition of Ca(2+) influx(1141).

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)

(1010) The protective effect of peony extract on acute myocardial infarction in rats by Mo X1, Zhao N, Du X, Bai L, Liu J.(PubMed)
(1011) Paeoniflorin protects against concanavalin A-induced hepatitis in mice. by Chen M1, Cao L2, Luo Y3, Feng X4, Sun L5, Wen M6, Peng S7.(PubMed)
(1012) [Treatment of irritable bowel syndrome by Chinese medicine and pharmacy: an analysis of data mining on experiences of experts].[Article in Chinese] by Zhang BH1, Gao R, Li ZH, Li BS, Wang FY, Tang XD.(PubMed)
(1013) Antioxidant and anti-inflammatory effects of Schisandra and Paeonia extracts in the treatment of asthma by Chen X1, Huang Y1, Feng J1, Jiang XF1, Xiao WF1, Chen XX1.(PubMed)
(1014) The effect of a traditional Chinese prescription for a case of lung carcinoma by Kamei T1, Kumano H, Iwata K, Nariai Y, Matsumoto T.(PubMed)
(1015) [Effect of a peony root preparation on the status of the insulin and hemostatic system in animals during development of alloxan diabetes].[Article in Russian] by Ul'ianov AM, Tarasov IuA, Liapina LA, Pastorova VE, Uspenskaia MS.(PubMed)
(1016) Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice by Kim JJ1, Choi J1, Lee MK2, Kang KY3, Paik MJ3, Jo SK4, Jung U4, Park HR4, Yee ST5.(PubMed)
(1017) Shao Yao(Complementary and Alternative Healing University)
(1018) Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin by Liu J1, Wang JS, Kong LY.(PubMed)
(1019) A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo by Fujiwara H1, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M,Yaegashi N, Kase Y, Arai H.(PubMed)
(1020) Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists by Liu DZ1, Xie KQ, Ji XQ, Ye Y, Jiang CL, Zhu XZ.(PubMed)
(1021) Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells by Wang D1, Tan QR, Zhang ZJ.(PubMed)
(1022) Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway.by Dong H1, Li R2, Yu C1, Xu T1, Zhang X1, Dong M3.(PubMed)
(1023) Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling by Liu MH1, Lin AH1, Lee HF2, Ko HK3, Lee TS1, Kou YR1.(PubMed)
(1024) [Advance in studies on effect of paeoniflorin on nervous system].[Article in Chinese] by Hu ZY1, Xu L, Yan R, Huang Y, Liu G, Zhou WX, Zhang YX.(PubMed)
(1025) Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease by Zhou J1, Zhou L, Hou D, Tang J, Sun J, Bondy SC.(PubMed)
(1026) Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task by Ohta H1, Matsumoto K, Shimizu M, Watanabe H.(PubMed)
(1027) [Effects of total paeony glucosides on mRNA expressions of Toll receptors and interleukin-33 in the brain tissue of D-galactose induced aging rats: an experimental research].[Article in Chinese] by Zhang HY1, Liu ZJ, Chen ZW.(PubMed)
(1028) [Advance in studies on effect of paeoniflorin on nervous system].[Article in Chinese] by Hu ZY1, Xu L, Yan R, Huang Y, Liu G, Zhou WX, Zhang YX.(PubMed)
(1028a) Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists by Liu DZ1, Xie KQ, Ji XQ, Ye Y, Jiang CL, Zhu XZ.(PubMed)
(1029) Mechanism of 6-hydroxydopamine neurotoxicity by Glinka Y1, Gassen M, Youdim MB.(PubMed)
(1030) Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway by Dong H1, Li R2, Yu C1, Xu T1, Zhang X1, Dong M3.(PubMed)
(1031) Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease by Kim HG1, Park G2, Piao Y3, Kang MS4, Pak YK3, Hong SP1, Oh MS5.(PubMed)
(1032) Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway by Sun R1, Wang K, Wu D, Li X, Ou Y.(PubMed)
(1033) Polyphenols and neuroprotection against ischemia and neurodegeneration. by Lin B1.(PubMed)
(1034) Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy by Chia-Chen Liu,1 Takahisa Kanekiyo,2 Huaxi Xu,1 and Guojun Bu1(PMC)
(1035) Increased A beta 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene by Ishii K1, Ii K, Hasegawa T, Shoji S, Doi A, Mori H.(PubMed)
(1036) Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease by Lippa CF, Nee LE, Mori H, St George-Hyslop P.(PubMed)
(1037) Peoniflorin attentuates Abeta((1-42))-mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats by Zhong SZ1, Ge QH, Li Q, Qu R, Ma SP.(PubMed)
(1038) A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia by Metzler-Baddeley C1.(PubMed)
(1039) Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats. by Lan Z1, Chen L2, Fu Q1, Ji W1, Wang S1, Liang Z1, Qu R3, Kong L4, Ma S5.(PubMed)
(1040) Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats by Liu J1, Jin DZ, Xiao L, Zhu XZ.(PubMed)
(1041) Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats by Xiao L1, Wang YZ, Liu J, Luo XT, Ye Y, Zhu XZ.(PubMed)

The holistic Prevention, Management and Treatment of Dementia due to Spleen Qi deficiency - TCM Herbal Safflower (Hong Hua)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.


   TCM Treatment of Dementia Induced by Spleen Qi deficiency - TCM Herbal Safflower (Hong Hua)

Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.1. Deficiency of Qi, mainly due to
B.3.3. Spleen Qi deficiency
Spleen is a vital organ, according to traditional Chinese medicine, with function in absoring nutrients and transporting them to body's organs and cells. Spleen Qi deficiency is a condition of the inability of the spleen in maximized transportation of nutrients to body organs, including the brain. Prolong period of malnutrition of brain cells may induce abnormal functions in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842).



3. Safflower (Hong Hua)
Safflower, is an acrid, warm herb in nature, used in tradition Chinese medicine as anti-bacterial(1070), anti viral(1068)(1069), analgesic(1071), diabetic(1072)(1073), immune stimulant(1074), anti-inflammatory(1071), anti-spasmodic(1075) agents. As a blood tonic in Chinese medicine, the herb is effective in treating dysmenorrhea(1075), amenorrhea(1075), by breaking up blood stagnation|(1077)(11078), improving blood flow(15) through warm-pungent-liver efficiency network(1079) and regulation of female reproductivehormone(1080) via liver, heart channels(1076).

Phytochemicals
1. Neocarthamin
2. Carthamin
3. Carthamone
4. Carthamidin
5. Saffloryellow
6. Saffloryellow-A
7. Apalmitic acid
8. Myristic acid
9. Lauric acid
10. Etc.

Herbal Safflower (Hong Hua) used in the treatment of symptoms of degenerative diseases(1091) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals, including major constituent hydroxy-safflor yellow A(1081)baicalin, baicalein, wogonin(1088), in exertion of its neuroprotective effects(1082)(1083), through anti oxidative stress(1086), anti inflammatory(1084))(1085) activities, against β-amyloid (Aβ) accumulation(1081) induced neurotoxicity causes of Alzheimer's disease.(1087)(1089) and neurodegeneration(1090).

3.1. In Alzheimer's disease
Neuroinflammation has shown to be a major contribution to the development of Alzheimer's disease (AD)(1092). Hydroxy-safflor yellow A (HSYA), isolated from safflower, inhibited Aβ 1-43₁ induced inflammation(1096) through anti microglia-mediated neurotoxicity activity(1094). In PC12 cells induced by β-amyloid neurotoxicity, the phytochemical also inhibited cell viability, glutathione level, through ameliorated enzymes found extensively in body tissues, formation of DNA fragmentation, levels of reactive oxygen species(1095) and reduced pro-inflammatory mediators(1097).


3.2. In Neuroprotective effects(1098)
Hydroxy-safflor yellow A (HSYA) at the molecular level, showed to inhibite energy metabolism disruption, excitatory amino acid toxicity, oxidative stress caused by impaired metabolism in rats with ischemia, through suppressing proinflammatory and upregulating anti-inflammatory mechanism(1099). According to Tianjin Medical University General Hospita, the herb also exerted its neuroprotective effects by inhibiting the accumulation of amyloid-β peptide (Aβ), a major protein component of senile plaques induced neurotoxicity via decreased production of reactive oxygen and nitrogen species(1101), ROS marker, malondialdehyde, and increased the level of glutathione, stabilized mitochondrial membrane(1100) and protected against excitotoxic neuronal death(1102).

3.3. In memory dysfunction
Intake of safflower oil has shown to improve learning and memory ability in n-3 fatty acid deficient male mice(1103) and in an age-related neuro deteriorative mouse model(1106), probably through modulated physiological properties of entorhinal cortex neurons(1104) and the balance of ratio of brain phospholipid(1107), respectively. Nicotiflorin, a natural flavonoid extracted from safflower, in cerebral multi-infarct dementia in rats model, showed to enhance spatial memory through reducd ROS production(1105).

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Using Holistic Ancient Chinese Medicine

References
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)

(1070) Possibility of fighting food borne bacteria by egyptian folk medicinal herbs and spices extracts by Tayel AA1, El-Tras WF.(PubMed)
(1071) Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L by Wang Y1, Chen P1, Tang C1, Wang Y1, Li Y1, Zhang H2.(PubMed)
(1072) Dietary treatments enriched in olive and safflower oils regulate seric and placental matrix metalloproteinases in maternal diabetes. by Martinez N1, Sosa M, Higa R, Fornes D, Capobianco E, Jawerbaum A.(PubMed)

(1073) Folic acid and safflower oil supplementation interacts and protects embryos from maternal diabetes-induced damage by Higa R1, Kurtz M, Mazzucco MB, Musikant D, White V, Jawerbaum A.(PubMed)
(1074) [Effects of Hengyan medicinal recipe on the regulation of immunity in patients with severe sepsis: a prospective clinical trial].[Article in Chinese] by Zhang ZH1, Zhou G, Gong X, Zhang R, Qu XG, Zeng C, Liu JL.(PubMed)
(1075) Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: a phytochemical and pharmacological review by Zhou X1, Tang L1, Xu Y1, Zhou G1, Wang Z2.(PubMed)
(1076) Hong Hua(Complementary and Alternative Healing University)
(1077) [Effect of jiantai liquid on expression of estrogen and progesterone receptors in uterus of mice with embryo implantation dysfunction induced by mifepristone].[Article in Chinese] by Liu YJ1, Huang GY, Yang MW, Gong P, Lu F.(PubMed)
(1078) [A clinical study of Safflower Yellow injection in treating coronary heart disease angina pectoris with Xin-blood stagnation syndrome].[Article in Chinese by Zhang Q1, Peng JH, Zhang XN.(PubMed)
(1079) [Analysis on anti-hepatoma effect of medicine invigorating blood circulation and eliminating blood stasis based on warm-pungent-liver efficiency network].[Article in Chinese] by Gu H, Ma L, Yuan B, Zhang YL, Wang Y, Qiao YJ.(PubMed)
(1080) Huangqi-Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats by Cao J1, Chen Z2, Zhu Y1, Li Y1, Guo C1, Gao K1, Chen L1, Shi X1, Zhang X1, Yang Z3, Wen A4.(PubMed)
(1081) Huangqi-Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats by Cao J1, Chen Z2, Zhu Y1, Li Y1, Guo C1, Gao K1, Chen L1, Shi X1, Zhang X1, Yang Z3, Wen A4.(PubMed)
(1082) Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats by Huang JL1, Fu ST, Jiang YY, Cao YB, Guo ML, Wang Y, Xu Z.(PubMed)
(1083) Protective effects of hydroxysafflor yellow A on β-amyloid-induced neurotoxicity in PC12 cells by Kong SZ1, Xian YF, Ip SP, Lai XP, Shi XG, Lin ZX, Su ZR.(PubMed)
(1084) Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ₁₋₄₂ in BV-2 cells by Zhang Z1, Wu Z2, Zhu X2, Hui X3, Pan J2, Xu Y4.(PubMed)
(1085) Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation by Li J1, Zhang S, Lu M, Chen Z, Chen C, Han L, Zhang M, Xu Y.(PubMed)
(1086) Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl(4)-induced liver damage in rats via the Nrf2 pathway by Wu S1, Yue Y, Tian H, Li Z, Li X, He W, Ding H.(PubMed)
(1087) Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease by Calon F1, Lim GP, Morihara T, Yang F, Ubeda O, Salem N Jr, Frautschy SA, Cole GM.(PubMed)
(1088) Polyphenols and neuroprotection against ischemia and neurodegeneration by Lin B1.(PubMed)
(1089) Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease by Park SY1, Kim MJ2, Kim YJ2, Lee YH3, Bae D4, Kim S4, Na Y5, Yoon HG1.(PubMed)
(1090) Timing of neurodegeneration and beta-amyloid (Abeta) peptide deposition in the brain of aging kokanee salmon by Maldonado TA1, Jones RE, Norris DO.(PubMed)
(1091) Polyphenols and neuroprotection against ischemia and neurodegeneration by Lin B1.(PubMed)
(1092) Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors by Liu C1, Cui G2, Zhu M3, Kang X4, Guo H5(PubMed)
(1093) The evolving biology of microglia in Alzheimer's disease by Malm TM1, Jay TR, Landreth GE.(PubMed)
(1094) Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ₁₋₄₂ in BV-2 cells by Zhang Z1, Wu Z2, Zhu X2, Hui X3, Pan J2, Xu Y4.(PubMed)
(1095) Protective effects of hydroxysafflor yellow A on β-amyloid-induced neurotoxicity in PC12 cells by Kong SZ1, Xian YF, Ip SP, Lai XP, Shi XG, Lin ZX, Su ZR.(PubMed)
(1096) Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation. by Li J1, Zhang S, Lu M, Chen Z, Chen C, Han L, Zhang M, Xu Y.(PubMed)
(1097) Hydroxy-safflor yellow A attenuates Aβ₁₋₄₂-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway by Zhang ZH1, Yu LJ2, Hui XC3, Wu ZZ2, Yin KL2, Yang H4, Xu Y5.(PubMed)
(1098) Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats by Xu RA1, Xu ZS2, Ge RS3.(PubMed)
(1099) A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by 1H NMR-Based Metabonomics and the NF-κB Pathwa by Yuanyan Liu, 1 , 2 Zeqin Lian, 1 Haibo Zhu, 1 Yinghong Wang, 1 ,* Shishan Yu, 1 ,* Tingting Chen, 1 Jing Qu, 1 Jianbei Li, 1Shuanggang Ma, 1 and Xianhong Chen 1(PMC)
(1100) Protective effect of isorhynchophylline against β-amyloid-induced neurotoxicity in PC12 cells by Xian YF1, Lin ZX, Mao QQ, Ip SP, Su ZR, Lai XP.(PubMed)
(1101) Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: inhibition of protein oxidation/nitration, 12/15-lipoxygenase and blood-brain barrier disruption by Sun L1, Yang L, Xu YW, Liang H, Han J, Zhao RJ, Cheng Y.(PubMed)
(1102) Neuroprotective effects of hydroxysafflor yellow A against excitotoxic neuronal death partially through down-regulation of NR2B-containing NMDA receptors by Yang Q1, Yang ZF, Liu SB, Zhang XN, Hou Y, Li XQ, Wu YM, Wen AD, Zhao MG.(PubMed)
(1104) Dietary intake of unsaturated fatty acids modulates physiological properties of entorhinal cortex neurons in mice by Arsenault D1, Julien C, Chen CT, Bazinet RP, Calon F.(PubMed)
(1105) Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats by Huang JL1, Fu ST, Jiang YY, Cao YB, Guo ML, Wang Y, Xu Z.(PubMed)
(1106) Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM) by Umezawa M1, Ohta A, Tojo H, Yagi H, Hosokawa M, Takeda T.(PubMed)
(1107) High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice by Umezawa M1, Kogishi K, Tojo H, Yoshimura S, Seriu N, Ohta A, Takeda T, Hosokawa M.(PubMed)

The holistic Prevention, Management and Treatment of Dementia due to Spleen Qi deficiency - TCM Herbal Chain Hu (Bupleurum)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.


   TCM Treatment of Dementia Induced by Spleen Qi deficiency - TCM Herbal Chain Hu (Bupleurum)

Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.1. Deficiency of Qi, mainly due to
B.3.3. Spleen Qi deficiency
Spleen is a vital organ, according to traditional Chinese medicine, with function in absoring nutrients and transporting them to body's organs and cells. Spleen Qi deficiency is a condition of the inability of the spleen in maximized transportation of nutrients to body organs, including the brain. Prolong period of malnutrition of brain cells may induce abnormal functions in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842).



2. Chai Hu (Bupleurum)
Chai Hu, the bitter, slightly cold herb is also known as bupleurum root, used in TCM as antitrypanosomal, antimicrobial and antiviral, such as cold and influenza, alternated chill and fever, malaria(1047), cytotoxic(1045) and anti-cancer agents(1046) and to treat irregular menses, prolapse of uterus and rectum(1048), etc., as it regulates and clears heat, improves liver function, raises Yang(1048) and resolves depression and stagnation, etc. by enhancing the functions of liver, gall bladder, pericardium, triple burner channels.

Phytochemicals
1. β-terpinene
2. imonene
3. β-fenchene
4. ulegone
5. Isoborneol
6. β-terpineol
7. α-copaene
8. Humulene
9. A-farnesene10. Aromadendrene
11. Cis-caryophyllene
12. β-elemene,13. Gamma-muurolene
14. Patchoulane
15. Pootkatone
16. Ledol
17. Etc.

Herbal chai hu used in the treatment and prevention of dementia(1049)(1050) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in exertion of its neuroprotective effects(1051) through its cytoprotection of neuron, and neuroprotective mechanisms(1052), against apoptosis of neurons(1051) due to Aβ oligomer-induced neuronal damage(1060) in concentration of corticosterone on hippocampal neurons(1059) in a dose-dependent manner.
Yokukansan, a popular herbal combination in Japan and China, containing chai hu, may be the next potential herbal formula used for treatment of Alzheimer's disease, Lewy body disease, Parkinson's disease, especially for the behavioral and psychiatric symptoms of dementia BPSD)(1064)(1065)(1066).

2.1. In dementia symptoms
In dementia, Yokukansan, also known as TJ-54, composed of sev Angelica acutiloba, Atractylodes lancea, Bupleurum falcatum, Poria cocos, Glycyrrhiza uralensis, Cnidium officinale and Uncaria rhynchophylla,(1052)showed to ameliorate the memory disturbance, anxiety-like behavior, aggressive behaviors, decrease in social behaviors, learning deficits and non-cognitive defects(1055) through improvement of neuronal and astroglial cells, via inhibit glutamate-mediated excitotoxicity(1053)(1054). According to 1KeimeiMemorial Hospital in Japan, the formula also showed to improve behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD)(1056).

2.2. In Alzheimer's disease and dementia with Lewy bodies
In Alzheimer's disease, Yokukansan improved psychological symptoms of dementia (BPSD)(1058), such as hallucinations, agitation, anxiety, irritability or abnormal behavior(1057) in elderly patients1056). In patients with dementia with Lewy bodies, Kampo medicine, yokukansan (YKS), including chai hu, also improved behavioural and psychological symptoms of dementia (BPSD), through neuropsychiatric Inventory scores(1061).

2.3. In Parkinson's disease
In neuropsychiatric symptoms in patients with Parkinson's disease, yokukansan, containing Chai hu, using the Unified PD Rating Scale part III (UPDRS-III) and Hoehn and Yahr scale, showed effectively in ameliorated symptoms of delusions, agitation, depression, euphoria, disinhibition with aberrant motor activity but irritability(1062). In behavioral and psychological symptoms, the herbal formula, also exhibited improvements of these symptoms, without worsening cognitive function, ability to perform activities of daily living, or parkinsonism, after 4 weeks(1063). Yokukansankachimpihange, another formula containing chai hu, showed to exhibit anti hallucinate effects, through its major phytochemical atractylenolide III and β-eudesmol, via its antagonistic activity against serotonin receptors induced non-motor symptom of Parkinson's disease and various forms of dementias(1067).

According to traditional Chinese medicine, the effectiveness of a herbal formula, is not results of single ingredient or single herb itself, but the combination of all ingredients of all herbs in the formula, even some herbs in the formula may show significant efficacies in Western studies and clinical trials.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)
(1045) Anti-infective and cytotoxic properties of Bupleurum marginatum by Ashour ML, El-Readi MZ, Hamoud R, Eid SY, El Ahmady SH, Nibret E, Herrmann F, Youns M, Tahrani A, Kaufmann D, Wink M1.(PubMed)
(1046) Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells by Wang Q1, Zheng XL, Yang L, Shi F, Gao LB, Zhong YJ, Sun H, He F, Lin Y, Wang X.(PubMed)
(1047) Ethnoveterinary plant remedies used by Nu people in NW Yunnan of China by Shen S1, Qian J, Ren J.(PubMed)
(1048) Chai Hu(Complementary and Alternative Healing University)
(1049) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review by de Caires S1, Steenkamp V.(PubMed)
(1050) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(1051) Neuroprotective effects of total saikosaponins of Bupleurum yinchowense on corticosterone-induced apoptosis in PC12 cells by Li ZY1, Guo Z, Liu YM, Liu XM, Chang Q, Liao YH, Pan RL.(PubMed)
(1052) Ethanol extract of Bupleurum falcatum Linne and saikosaponins inhibit neuroinflammation via inhibition of NF-κB by Park WH1, Kang S1, Piao Y1, Pak CJ1, Oh MS2, Kim J3, Kang MS1, Pak YK4.(PubMed)
(1053)
(1054) Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells by Kawakami Z1, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, Kase Y.(PubMed)
(1055) Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease by Tabuchi M1, Yamaguchi T, Iizuka S, Imamura S, Ikarashi Y, Kase Y.(PubMed)
(1056) Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease by Okahara K1, Ishida Y, Hayashi Y, Inoue T, Tsuruta K, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Yoshida K, Noda S, Tomita S, Fujimoto M,Hosomi J, Mitsuyama Y.(PubMed)
(1057) Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice. by Hayashi Y1, Ishida Y, Inoue T, Udagawa M, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Sameshima T, Kawahara T, Goto I, Shudo K, Kurayama S, Nakamura J, Okahara K, Mitsuyama Y.(PubMed)
(1058) Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine by Rodda J1, Morgan S, Walker Z.(PubMed)
(1059) Neuroprotective effect of yokukansan against cytotoxicity induced by corticosterone on mouse hippocampal neurons. by Nakatani Y1, Tsuji M2, Amano T3, Miyagawa K4, Miyagishi H4, Saito A4, Imai T4, Takeda K4, Ishii D4, Takeda H2.(PubMed)
(1060) Glycyrrhiza and Uncaria Hook contribute to protective effect of traditional Japanese medicine yokukansan against amyloid β oligomer-induced neuronal death. by Kanno H1, Kawakami Z, Iizuka S, Tabuchi M, Mizoguchi K, Ikarashi Y, Kase Y.(PubMed)
(1061) Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine.
Iwasaki K1, Kosaka K, Mori H, Okitsu R, Furukawa K, Manabe Y, Yoshita M, Kanamori A, Ito N by Wada K, Kitayama M, Horiguchi J, Yamaguchi S, Takayama S,Fukuhara R, Ouma S, Nakano S, Hashimoto M, Kinoshita T.(PubMed)
(1062) An exploratory study of the efficacy and safety of yokukansan for neuropsychiatric symptoms in patients with Parkinson's disease. by Hatano T1, Hattori N, Kawanabe T, Terayama Y, Suzuki N, Iwasaki Y, Fujioka T; Yokukansan Parkinson’s Disease Study Group.(PubMed)
(1063) Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia by Kawanabe T1, Yoritaka A, Shimura H, Oizumi H, Tanaka S, Hattori N.(PubMed)
(1064) New possibility of traditional Chinese and Japanese medicine as treatment for behavioral and psychiatric symptoms in dementia by Kung FC1, Ishii R, Liu HC, Takeda M.(PubMed)
(1065) A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia by Mizukami K1, Asada T, Kinoshita T, Tanaka K, Sonohara K, Nakai R, Yamaguchi K, Hanyu H, Kanaya K, Takao T, Okada M, Kudo S, Kotoku H, Iwakiri M, Kurita H, Miyamura T, Kawasaki Y, Omori K, Shiozaki K, Odawara T, Suzuki T, Yamada S, Nakamura Y, Toba K.(PubMed)
(1066) Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions. by Okamoto H1, Iyo M2, Ueda K3, Han C3, Hirasaki Y3, Namiki T3.(PubMed)
(1067) Pharmacological effects of "jutsu" (Atractylodis rhizome and Atractylodis lanceae rhizome) on 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head twitch response in mice (I).

Murayama C1, Wang CC2, Michihara S3, Norimoto H4.(PubMed)