The holistic Prevention, Management and Treatment of Dementia - The Antioxidant Metals binding proteins Ceruloplasmin

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                           The Antioxidant Metals binding proteins Ceruloplasmin


The expression of metal-binding proteins or peptides in microorganisms and plants in order to enhance heavy metal accumulation and/or tolerance has great potential, according to Dr. Malin Mejárea, Leif Bülow in the study of Metal-binding proteins and peptides in bioremediation and phytoremediation of heavy metals, leading to reduced oxidative stress defence in plants.


2. Ferritin
Ferritin, the protein produced by almost all living organisms, acts as a component to fight against iron deficiency and iron overload(233)(234). In a soluble and non-toxic form, the protein is transported to the body needs, including organs(236) for enhancement of the immune system in the presence of an infection(237), against proliferation of lymphoid and myeloid cells(235), cancer(238) and prevention of the infectious agent in attempt of binding iron to form free radicals(239) in most cellular oxidation reactions(239).


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The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(233) Sulforaphane reduces the alterations induced by quinolinic acid: modulation of glutathione levels. by Santana-Martínez RA1, Galván-Arzáte S2, Hernández-Pando R3, Chánez-Cárdenas ME1, Avila-Chávez E4, López-Acosta G1, Pedraza-Chaverrí J5,Santamaría A6, Maldonado PD7.(PubMed)
(234) Ferritin in the red cells of normal subjects and patients with iron deficiency and iron overload. by Cazzola M, Arosio P, Barosi G, Bergamaschi G, Dezza L, Ascari E.(PubMed)
(235) New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. by Recalcati S1, Invernizzi P, Arosio P, Cairo G.(PubMed)
(236) CoCl2-induced biochemical hypoxia down regulates activities and expression of super oxide dismutase and catalase in cerebral cortex of mice. by Rani A1, Prasad S.(PubMed)
(237) Transferrin and ferritin response to bacterial infection: the role of the liver and brain in fish. by Neves JV1, Wilson JM, Rodrigues PN.(PubMed)
(238) The significance of ferritin in cancer: anti-oxidation, inflammation and tumorigenesis. by Alkhateeb AA1, Connor JR.(PubMed)
(239) The iron-binding protein Dps2 confers peroxide stress resistance on Bacillus anthracis. by Tu WY1, Pohl S, Gizynski K, Harwood CR.(PubMed)

The holistic Prevention, Management and Treatment of Dementia - The Antioxidant Metals binding proteins Ceruloplasmin

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

      The Antioxidant Metals binding proteins Ceruloplasmin


The expression of metal-binding proteins or peptides in microorganisms and plants in order to enhance heavy metal accumulation and/or tolerance has great potential, according to Dr. Malin Mejárea, Leif Bülow in the study of Metal-binding proteins and peptides in bioremediation and phytoremediation of heavy metals, leading to reduced oxidative stress defence in plants.

1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood, plays a role iniron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of superoxide anion radicals(231) and iron overload in the brain, liver, pancreas, and other organs(232).


Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(227) Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. by Ariza J1, Steward C2, Rueckert F2, Widdison M2, Coffman R2, Afjei A2, Noctor SC3, Hagerman R4, Hagerman P5, Martínez-Cerdeño V6.(PubMed)
(228) Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease byYoo MH1, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL.(PubMed)
(229) Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. by Kono S1, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H.(PubMed)
(230) Ceruloplasmin-ferroportin system of iron traffic in vertebrates. by Musci G1, Polticelli F1, Bonaccorsi di Patti MC1.(PubMed)
(231) Ceruloplasmin: an acute phase reactant that scavenges oxygen-derived free radicals. by Goldstein IM, Kaplan HB, Edelson HS, Weissmann G.(PubMed)
(232) Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice by Antunes MS1, Goes AT1, Boeira SP1, Prigol M1, Jesse CR2.(PubMed)

The holistic Prevention, Management and Treatment of Dementia - The Antioxidant enzymes Super oxide dismutase (both Cu-Zn and Mn)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                 The Antioxidant enzymes Super oxide dismutase (both Cu-Zn and Mn)


Antioxidant enzymes, chemical substances found in plants, protect the body from damage of free radicals by terminating the chain reactions through removing free radical intermediates and inhibiting oxidation reactions.

4. Super oxide dismutase (both Cu-Zn and Mn)
Super oxide dismutase is an important antioxidant and immune defence(224) in nearly all cells exposed to oxygen by converting superoxide into oxygen and hydrogen peroxide, depending on the metal cofactor such as both Cu-Zn and Mn(225), probably through the attenuation of superoxide dismutases (SODs) and catalases (CATs)(225) in enhanced protection of biochemical/molecular/neurobiological function(226).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


References
(233) Sulforaphane reduces the alterations induced by quinolinic acid: modulation of glutathione levels. by Santana-Martínez RA1, Galván-Arzáte S2, Hernández-Pando R3, Chánez-Cárdenas ME1, Avila-Chávez E4, López-Acosta G1, Pedraza-Chaverrí J5,Santamaría A6, Maldonado PD7.(PubMed)
(234) Ferritin in the red cells of normal subjects and patients with iron deficiency and iron overload. by Cazzola M, Arosio P, Barosi G, Bergamaschi G, Dezza L, Ascari E.(PubMed)
(235) New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. by Recalcati S1, Invernizzi P, Arosio P, Cairo G.(PubMed)
(236) CoCl2-induced biochemical hypoxia down regulates activities and expression of super oxide dismutase and catalase in cerebral cortex of mice. by Rani A1, Prasad S.(PubMed)

The holistic Prevention, Management and Treatment of Dementia - The Antioxidant Glutathione reductase

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                           The Antioxidant enzymes Catalase


Antioxidant enzymes, chemical substances found in plants, protect the body from damage of free radicals by terminating the chain reactions through removing free radical intermediates and inhibiting oxidation reactions.

3. Glutathione reductase
Glutathione reductase, an antioxidant enzyme capable to regenerate Gglutathione (GSH) levels at 24h(233), and reduced pair of sulfur atoms glutathione to a organosulfur compound form of antioxidant (consisting of three amino acids joined by peptide bonds) may play an important role in prevention of damage of important cellular components induced neurodegenerative diseases such as PD(231)(232), caused by free radicalsand peroxides. probably through its antioxidant and anti-inflammatory properties(231)


Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


(231) Ceruloplasmin: an acute phase reactant that scavenges oxygen-derived free radicals. by Goldstein IM, Kaplan HB, Edelson HS, Weissmann G.(PubMed)
(232) Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice by Antunes MS1, Goes AT1, Boeira SP1, Prigol M1, Jesse CR2.(PubMed)
(233) Sulforaphane reduces the alterations induced by quinolinic acid: modulation of glutathione levels. by Santana-Martínez RA1, Galván-Arzáte S2, Hernández-Pando R3, Chánez-Cárdenas ME1, Avila-Chávez E4, López-Acosta G1, Pedraza-Chaverrí J5,Santamaría A6, Maldonado PD7.(PubMed)

The holistic Prevention, Management and Treatment of Dementia - The Antioxidant enzymes Glutathione peroxidase

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

          The Antioxidant enzymes  Glutathione peroxidase


Antioxidant enzymes, chemical substances found in plants, protect the body from damage of free radicals by terminating the chain reactions through removing free radical intermediates and inhibiting oxidation reactions.

2. Glutathione peroxidase
The function of glutathione peroxidase is to protect the organism from oxidative damage and induced neurodegenerative diseases, such as Alzheimer's disease(228) by removing lipid hydroperoxides(227), causes of oxidation of lipid cell membranes. probably through its major cellular peroxide scavenging enzyme(228) and maintaining the oxidative phosphorylation system and protecting mitochondria(229) and oxidative injury and amyloid toxicity of cortical neurons(230).


Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


(227) Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. by Ariza J1, Steward C2, Rueckert F2, Widdison M2, Coffman R2, Afjei A2, Noctor SC3, Hagerman R4, Hagerman P5, Martínez-Cerdeño V6.(PubMed)
(228) Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease byYoo MH1, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL.(PubMed)
(229) Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. by Kono S1, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H.(PubMed)
(230) Ceruloplasmin-ferroportin system of iron traffic in vertebrates. by Musci G1, Polticelli F1, Bonaccorsi di Patti MC1.(PubMed)

Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References

The holistic Prevention, Management and Treatment of Dementia - The Antioxidant enzymes Catalase

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                           The Antioxidant enzymes Catalase

Antioxidant enzymes, chemical substances found in plants, protect the body from damage of free radicals by terminating the chain reactions through removing free radical intermediates and inhibiting oxidation reactions.

1. Catalase
Catalase is an enzyme, found in most living organisms exposed to oxygen for action of converse hydrogen peroxide (free radicals)(226) to water and oxygen. The antioxidants showed to protect cells against the toxic effects of hydrogen peroxide in pathogenesis of oxidative stress-related diseases(222) inducted early stages of aggregation of the amyloid peptides(225), including neurodegeneration(224) such as Alzheimer's diseas(223).


Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

(222) Human catalase, its polymorphisms, regulation and changes of its activity in different diseases. by Kodydková J1, Vávrová L1, Kocík M1, Žák A1.(PubMed)
(223) Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment. by Cervellati C1, Romani A1, Seripa D2, Cremonini E1, Bosi C3, Magon S3, Bergamini CM1, Valacchi G4, Pilotto A5, Zuliani G3.(PubMed)
(224) Neurodegeneration through oxidative stress: monitoring hydrogen peroxide induced apoptosis in primary cells from the subventricular zone of BALB/c mice using field-effect transistors. by Koppenhöfer D1, Kettenbaum F1, Susloparova A1, Law JK1, Vu XT1, Schwab T1, Schäfer KH1, Ingebrandt S2.(PubMed)
(225) Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia. byTabner BJ1, El-Agnaf OM, Turnbull S, German MJ, Paleologou KE, Hayashi Y, Cooper LJ, Fullwood NJ, Allsop D.(PubMed)
(226) Development of a new catalase activity assay for biological samples using optical CUPRAC sensor. by Bekdeşer B1, Özyürek M1, Güçlü K2, Alkan FÜ3, Apak R1.(PubMed)

The holistic Prevention, Management and Treatment of Dementia - The Complications

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                          The Complications

According to physical complications of patients with dementia occurred in the 12 months from April 2007 to March 2008 recorded in Ichinomiya CityHospital, Ichinomiya, the physical complications can be divided into two categories:
** Serious emergencies occurred with a possible high risk of mortality within a few days (e.g. pneumonia and upper airway obstruction); and
**Life-threatening complications arising required diagnosis and treatment by specialists from other medical departments (e.g. bone fracture andcancer)(202).

1. Pneumonia
Pneumonia is common among patients with advanced dementia, especially toward the end of life, due to microbial infection, according to Beth IsraelDeaconess Medical Center(203).

2. Obstructive Sleep Apnea Syndrome (OSAS)
The prevalence of OSAS increased with aging, occurring in up to 25% of older adults and up to 48% in patients with Alzheimer's disease, showed to induce symptoms of hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage, due to reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss(204)

3. Bone fracture
Bone mass and dementia in elderly hip fracture patients may be associated to levels of different aluminium concentrations in water supplies in the areas affecting the negative calcium balance of age-related osteoporosis together predispose to senile dementia.(205)

4. Urinary incontinence
Urinary incontinence is a common problem in dementia. Almost invariably, the person with dementia will develop incontinence as the diseaseprogresses. However, the primary reasons for incontinence are often not because of any significant pathology in the urinary system. Rather, it is due to factors outside the urinary system, including insertion of tube in assisting urinary flow(206)

5. Venous thromboembolism
Venous thromboembolism (VTE), caused by a blood clot breaking loose and traveling in the blood, in patients with dementia had a high incidence of fatal pulmonary embolism (PE) and fatal bleeding, according to the study of 37988 patients with 1316 (3.5%) having dementia(207).

6. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine


References
(202) Physical complications for elderly inpatients with senile dementia in the Imaise Branch of Ichinomiya City Hospital by Ukai K1, Mizuno Y.(PubMed)
(203) Survival and comfort after treatment of pneumonia in advanced dementia. b Givens JL1, Jones RN, Shaffer ML, Kiely DK, Mitchell SL.(PubMed)
(204) [Obstructive sleep apnea and cognitive impairment in the elderly].[Article in French]by Onen F1, Onen H.(PubMed)
(205) Bone mass and dementia in hip fracture patients from areas with different aluminium concentrations in water supplies.by Wood DJ1, Cooper C, Stevens J, Edwardson J.(PubMed)
(206) Urinary incontinence in dementia - a practical approach. by Yap P1, Tan D.(PubMed)
(207) Venous thromboembolism in immobilized patients with dementia. Findings from the RIETE registry. by Nuñez MJ, Villalba JC, Cebrián E, Visoná A, Lopez-Jimenez L, Núñez M, Szwebel TA, Luque JM, Jaras MJ, Monreal M; RIETE Investigators.(PubMed)