Saturday, 12 December 2015

Most Common Diseases of elder: The Clinical Trials and Studies of Musculo-Skeletal disorders: Osteoporosis Treatment : Life style modification herbal and traditional Chinese medicine perspective

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                Osteoporosis

Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. It is a widespread degenerative disease of skeletal joints and often associated with senescence in vertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(6).


                               The Treatment

B. In herbal  and traditional Chinese medicine perspective
B.1. Life style modification according herbal and TCM medicine specialist
Life style modification has shown to be beneficiary for patients with osteoarthritis, osteoporosis and rheumatoid arthritis to improve musculoskeletal and bone health and reduce disability, according to the University of Tasmania(383). Modern herbal and TCM medicine specialists may suggest the following
1. Maintain proper weight
Lean women and women with abnormal weight change are found to associate the risk factors and risk of proximal femur bone loss(384).
According to the joint study lead by the David Geffen School of Medicine at University of California, Los Angeles, Postmenopausal weight change such as weight gain, weight loss, and intentional weight loss are associated with increased incidence of fracture, including upper limbs, lower limbs, and central body; hip fracture,...(385). 

2. Physical activity
Exercise, today is less popular leisure-time activity in many countries throughout the Western world, especially in the youth due to promotion of information collection through mobile phone. According to study, moderate exercise, has found to prevent and ameliorated the risk of osteoporosis(389). A physically active women has found to associate to reduce risk of osteoporosis (384) in compared with physically inactive women(386). According to the Federal University of São Paulo, physical exercise is an important stimulus for osteoporosis, as it improves bone microarchitecture, bone density and bone strength, as well as increasing physical function(387), through the stimulation of bone tissue, muscle strength and muscle contraction(387).
6-month whole body vibration training, in older women reduced risk factors for falls and fractures, the Faculteit Lichamelijke Opvoeding en Kinesitherapie suggested(388).

Exercise training showed to  reduce bone turnover, improve hip bonemineral density despite decline in bone-active hormones in in obese hormone decreased aging adults(390).

3. Stop smoking
Smoking, a behavioral risk factor has long been known for its negative effects on over health, causing 3.3 billions pounds of unnecessary burden to the health care system on UK alone(428).
The 2003/2004 South African Demographic and Health Survey, suggested that smoking is positively associated with osteoporosis and lifetime use of both snuff and cigarettes may increase risk osteoporosis among women who are 40 years and older(429). DR. Kim KH, and the research team at the Seoul National University College of Medicine in the study of second hand smoke said " postmenopausal never-smoking Korean women, exposure to SHS was positively associated with osteoporosis". Postmenopausal Women who are exposured to SMS are found to associate to increased occurrences for lumbar and femoral neck osteoporosis if hercohabitant smokers consumed ≥20 cigarettes/day(430). 
In fact, the researchers at the Catholic University of Korea in the study of smoking relationship between smoking and bone mineral density (BMD) showed that urinary continence level is directly related to the BMD at femur neck, total femur, and lumbar spine among postmenopausal females in dose depend-manner(431).

4. Alcoholism
Moderate alcohol drinking has long been associated to over all health and longevity. In dose depent-manner, alcohol intake among menopausal women are highly significant correlated with osteoporosis, causing the quantity and quality of BMD declines gradually or even rapidly(432). A radiographic survey of 96 fully ambulatory male patient with chronic alcoholism between age ranged from 24 to 62 year showed that osteoporosis is found in most of the patient regardless of age. Bone loss has also found in patient relatively young from age 31 to 45 years(427).
The joint study lead by State University of Sao Paulo also insisted that chronic alcoholism may affect bones in general through induced apoptosis of osteoblasts and osteocytes and bone cells(433).


Ovarian Cysts And PCOS Elimination

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References
(1) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study by Dai SM1, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM.(PubMed)
(2) Musculoskeletal Disorders in the Elderly by Ramon Gheno, Juan M. Cepparo, Cristina E. Rosca,1 and Anne Cotten(PMC)
(3) Osteoporosis(Life extension)
(5) Growth hormone and bone by Ohlsson C1, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC.(PubMed)
(6) GH and bone--experimental and clinical studies by Isaksson OG1, Ohlsson C, Bengtsson BA, Johannsson G.(PubMed)
(383) Lifestyle modifications to improve musculoskeletal and bone health and reduce disability--a life-course approach by Jones G1, Winzenberg TM2, Callisaya ML3, Laslett LL4.(PubMed)
(384) Bone loss, physical activity, and weight change in elderly women: the Dubbo Osteoporosis Epidemiology Study by Nguyen TV1, Sambrook PN, Eisman JA.(PubMed)
(385) Postmenopausal weight change and incidence of fracture: post hoc findings from Women's Health Initiative Observational Study and Clinical Trials by Crandall CJ1, Yildiz VO2, Wactawski-Wende J3, Johnson KC4, Chen Z5, Going SB6, Wright NC7, Cauley JA8.(PubMed)
(386) Independent predictors of all osteoporosis-related fractures among healthy Saudi postmenopausal women: the CEOR Study by Rouzi AA1, Al-Sibiani SA, Al-Senani NS, Radaddi RM, Ardawi MS.(PubMed)
(387) Physical exercise and osteoporosis: effects of different types of exercises on bone and physical function ofpostmenopausal women by Moreira LD1, Oliveira ML1, Lirani-Galvão AP1, Marin-Mio RV1, Santos RN1, Lazaretti-Castro M1.(PubMed)
(388) Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control inpostmenopausal women: a randomized controlled pilot study by Verschueren SM1, Roelants M, Delecluse C, Swinnen S, Vanderschueren D, Boonen S.(PubMed)
(389) Physical activity in the prevention and amelioration of osteoporosis in women : interaction of mechanical, hormonal and dietary factors by Borer KT1.(PubMed)
(390) Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bonemineral density induced by weight loss despite decline in bone-active hormones by Shah K1, Armamento-Villareal R, Parimi N, Chode S, Sinacore DR, Hilton TN, Napoli N, Qualls C, Villareal DT.(PubMed)
(391) Osteoporosis and inflammation by Mundy GR1.(PubMed)
(392) An association between abnormal bone turnover, systemic inflammation, and osteoporosis in patients with chronic pancreatitis: a case-matched study by Duggan SN1, Purcell C1, Kilbane M2, O'Keane M2, McKenna M2, Gaffney P3, Ridgway PF1, Boran G3, Conlon KC4.(PubMed)
(393) [Regulation of bone metabolism in osteoporosis : Novel drugs for osteoporosis in development].[Article in German]by Jakob F1, Genest F2, Baron G2, Stumpf U3, Rudert M2, Seefried L2.(PubMed)
(394) The effect of garlic tablet on pro-inflammatory cytokines in postmenopausal osteoporotic women: a randomized controlled clinical trial by Mozaffari-Khosravi H1, Hesabgar HA, Owlia MB, Hadinedoushan H, Barzegar K, Fllahzadeh MH.(PubMed)
(395) Role of peritoneal macrophages and lymphocytes in the development of hypogonadal osteoporosis in an ovariectomized rat model: possible phytoestrogenic efficacy of oil extract of garlic to preserve skeletal health by Mukherjee M1, Das AS, Das D, Mukherjee S, Mitra S, Mitra C.(PubMed)
(396) Role of oil extract of garlic (Allium sativum Linn.) on intestinal transference of calcium and its possible correlation with preservation of skeletal health in an ovariectomized rat model of osteoporosis by Mukherjee M1, Das AS, Das D, Mukherjee S, Mitra S, Mitra C.(PubMed)
(397) Effects of garlic oil on postmenopausal osteoporosis using ovariectomized rats: comparison with the effects of lovastatin and 17beta-estradiol by Mukherjee M1, Das AS, Das D, Mukherjee S, Mitra S, Mitra C.(PubMed)
(398) Prevention of bone loss by oil extract of garlic (Allium sativum Linn.) in an ovariectomized rat model ofosteoporosis by Mukherjee M1, Das AS, Mitra S, Mitra C.(PubMed)
(399) Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) by Chainani-Wu N1.(PubMed)
(400) Antioxidant and anti-inflammatory properties of curcumin by Menon VP1, Sudheer AR.(PubMed)
(401) A diarylheptanoid phytoestrogen from Curcuma comosa, 1,7-diphenyl-4,6-heptadien-3-ol, accelerates human osteoblast proliferation and differentiation by Tantikanlayaporn D1, Robinson LJ, Suksamrarn A, Piyachaturawat P, Blair HC.(PubMed)
(402) Bone sparing effect of a novel phytoestrogen diarylheptanoid from Curcuma comosa Roxb. in ovariectomized rats by Tantikanlayaporn D1, Wichit P, Weerachayaphorn J, Chairoungdua A, Chuncharunee A, Suksamrarn A, Piyachaturawat P.(PubMed)
(403) Curcumin: getting back to the roots by Shishodia S1, Sethi G, Aggarwal BB.(PubMed)
(404) The acute effects of green tea and carbohydrate coingestion on systemic inflammation and oxidative stress during sprint cycling by Suzuki K1, Takahashi M1, Li CY2, Lin SP3, Tomari M1, Shing CM4, Fang SH5.(PubMed)
(405) Green tea polyphenols change the profile of inflammatory cytokine release from lymphocytes of obese and lean rats and protect against oxidative damage by Molina N1, Bolin AP1, Otton R2.(PubMed)
(406) Green tea supplementation benefits body composition and improves bone properties in obese female rats fed with high-fat diet and caloric restricted diet by Shen CL1, Han J2, Wang S3, Chung E4, Chyu MC5, Cao JJ6(PubMed)
(407) Epigallocatechin-3-gallate (EGCG) as a pro-osteogenic agent to enhance osteogenic differentiation of mesenchymal stem cells from human bone marrow: an in vitro study by Jin P1, Wu H, Xu G, Zheng L, Zhao J.(PubMed)
(408) Dietary patterns and osteoporosis risk in postmenopausal korean women by Park SJ1, Joo SE, Min H, Park JK, Kim Y, Kim SS, Ahn Y.(PubMed)
(409) A natural formulation (imoviral™) increases macrophage resistance to LPS-induced oxidative and inflammatorystress in vitro by Menghini L1, Leporini L1, Pintore G2, Ferrante C1, Recinella L1, Orlando G1, Vacca M1, Brunetti L1.(PubMed)
(410) Dietary calcium and vitamin D2 supplementation with enhanced Lentinula edodes improves osteoporosis-like symptoms and induces duodenal and renal active calcium transport gene expression in mice by Lee GS1, Byun HS, Yoon KH, Lee JS, Choi KC, Jeung EB.(PubMed)
(411) The association between onion consumption and bone density in perimenopausal and postmenopausal non-Hispanic white women 50 years and older by Matheson EM1, Mainous AG 3rd, Carnemolla MA.(PubMed)
(412) [Osteoporosis diet].[Article in German] by Morselli B1, Neuenschwander B, Perrelet R, Lippuner K.(PubMed)
(413) Water solution of onion crude powder inhibits RANKL-induced osteoclastogenesis through ERK, p38 and NF-kappaB pathways by Tang CH1, Huang TH, Chang CS, Fu WM, Yang RS.(PubMed)
(360)
(416) Salmon calcitonin (Miacalcic) nasal spray in prevention and treatment of osteoporosis by Gennari C1.(PubMed)
(417) A randomized trial of nasal spray salmon calcitonin in men with idiopathic osteoporosis: effects on bone mineral density and bone markers by Trovas GP1, Lyritis GP, Galanos A, Raptou P, Constantelou E.(PubMed)
(418) Effects of salmon calcitonin treatment on serum and synovial fluid bone formation and resorption markers inosteoporosis patients by Atbinici H1, Sipahioğlu S2, Aksoy N3, Baykara İ2, Işıkan UE2.(PubMed)
(419) Salmon calcitonin in the treatment of elderly women with type 2 diabetes complicated with osteoporosis by Dexue L1, Yueyue Z2.(PubMed)
(420) Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial by Binkley N1, Bone H, Gilligan JP, Krause DS.(PubMed)
(421) A systematic review of omega-3 fatty acids and osteoporosis by Tonya S. Orchard,1 Xueliang Pan,2 Fern Cheek,3 Steven W. Ing,4 and Rebecca D. Jackson4(PMC)
(422) SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: Effects on cellular stress, inflammatory markers and fatty acid elongation by Ralston JC1, Metherel AH2, Stark KD3, Mutch DM4.(PubMed)
(423) Levels of bioactive lipids in cooking oils: olive oil is the richest source of oleoyl serine by Bradshaw HB, Leishman E.(PubMed)
(424) Stereological study of the effect of black olive hydroalcoholic extract on osteoporosis in vertebra and tibia in ovariectomized rats by Noorafshan A1, Dabbaghmanesh MH, Tanideh N, Koohpeyma F, Rasooli R, Hajihoseini M, Bakhshayeshkaram M, Hosseinabadi OK.(PubMed)
(425) Olive oil effectively mitigates ovariectomy-induced osteoporosis in rats by Saleh NK1, Saleh HA.(PubMed)
(426) Olive oil in the prevention and treatment of osteoporosis after artificial menopause by Liu H1, Huang H1, Li B1, Wu D1, Wang F1, Zheng Xh1, Chen Q1, Wu B1, Fan X1.(PubMed)
(427) Chronic alcoholism. Frequently overlooked cause of osteoporosis in men by Spencer H, Rubio N, Rubio E, Indreika M, Seitam A.(PubMed)
(428) The economic burden of ill health due to diet, physical inactivity, smoking, alcohol and obesity in the UK: an update to 2006-07 NHS costs by Scarborough P1, Bhatnagar P, Wickramasinghe KK, Allender S, Foster C, Rayner M.(PubMed)
(429) Epidemiological association between osteoporosis and combined smoking and use of snuff among South African women by Ayo-Yusuf OA1, Olutola BG.(PubMed)
(430) Secondhand smoke exposure and osteoporosis in never-smoking postmenopausal women: the Fourth Korea National Health and Nutrition Examination Survey by Kim KH1, Lee CM, Park SM, Cho B, Chang Y, Park SG, Lee K.(PubMed)
(431) Dose-related effect of urinary cotinine levels on bone mineral density among Korean females by Myong JP1, Kim HR, Choi SE, Koo JW.(PubMed)
(432) Prevalence and risk factors associated with osteoporosis in women attending menopause clinic at Hat Yai Regional Hospital by Jarupanich T1.(PubMed)
(433) Alcoholic and isocaloric diet, but not ovariectomy, influence the apoptosis of bone cells within the alveolar bone crest of rats by Marchini AM1, Gonçalves LL2, Salgado MC1, do Prado RF1, Marchini L3, Carvalho YR1, da Rocha RF1.(PubMed)

Friday, 11 December 2015

Most Common Diseases of elder: The Clinical Trials and Studies of Musculo-Skeletal disorders: Osteoporosis Treatment in Conventional Medicine Perspective

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                Osteoporosis

Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. It is a widespread degenerative disease of skeletal joints and often associated with senescence in vertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(6).



                                The Treatments


A. In conventional medicine perspective
The osteoporosis Canada suggested the following treatment for patient with osteoporosis depending to differentiation(350).
A.1. Bisphosphonates
1. Including Alendronate (Fosamax), Risedronate (Actonel, Atelvia), Ibandronate (Boniva), Zoledronic acid (Reclast, Zometa), etc..Bisphosphonates are antiresorptive medications widely prescribed for treatment of osteoporosis. The drugs, used most common treatment for osteoporotic patients, regardless to intravenous and oral alendronate administration(351) have shown to significantly reduce the risk of osteoporotic fractures(356). Higher risk patients should be treated bynonbisphosphonate for 10 yr, have a holiday of no more than a year or two(353), but drug holidays should be considered for low-risk patients and in select patients at moderate risk of fracture after 3 to 5 years of therapy(352).
It is suggested that patient under treatment of bisphosphonates therapy should also diet with rich of calcium and vitamin D.

2. Side effects are not limit to
2.1. Nausea
2.2. Abdominal pain
2.3. Difficulty swallowing
2.4. Risk of an inflamed esophagus or esophageal ulcers(354) and Esophageal Cancer(357)
2.5. Fever, myalgias, and arthralgias(357)
2.6.  Musculoskeletal pain(357)
2.7. Hypocalcium(357)
2.8. Risk of sclerosis and a variety of ocular side effects(355)(357)
2.9. Atrial Fibrillation(357)
2.10. Severe Suppression of Bone Turnover(357)
2.11. Subtrochanteric Femoral Fractures

A.2. Hormone therapy
1. Hormone Therapy (HT) or estrogen/progesterone therapy, is commonly used to relieve the symptoms of menopause, especially for women in pre-menopause state with low lower progesterone-to-estrogen level of that induced more negative changes in bone (358). According to the, treatment with estrogen/progesterone in post menopause women showed a protective effect against significant changes in BMD and follow-up BMD(359) against loss of ovarian function due to aging induced increasing risk of osteoporosis(360).
 Estrogen/progesterone therapy with no intention to replace  the loss of these hormones due to post menopause, but to supplement these hormones to the lowest level required to prevent bone loss.

2. Hormone replacement therapy can help to maintain bone density for menopause women, but it increases
2.1. The risk of breast cancer and heart disease(361)
2.2. The risk for venous thromboembolism(362)
2.3. The risk of (Nonmelanoma Skin Cancers) NMSC.(363)
2.4. The risk of stroke(364)
2.5. Other side effects may also include arthralgia and mucosal dryness(365),

A.3. Estrogen replacement therapy
3.1.  Estrogen therapy HT, most used in menopausal women for relieving symptoms such as hot flash, night sweats, mood and sleep disturbances, vaginal dryness and pain with intercourse, insomnia or problems sleeping, frequent urination or urinary incontinence etc.(367).
 Estrogen production in women before menopause plays such an important role in maintaining bone density by balancing the bone turn over through stimulating the calcium absorption and serum vitamin D metabolites against osteoporosis(366). According to the Yale University study, low-dose estrogen therapy may be a better choice for prevention of osteoporosis in menopausal women due to its benefits of significant increased bone mineral density and reductions in markers of bone turnover with no increased risk of endometrial hyperplasia or other side effects(368).

3.2. Adverse effects
Side effects of estrogen replacement therapy are swelling of the ankles and legs, loss of appetite, weight changes, retention of water, nausea, vomiting, abdominal cramps, and feeling of bloatednes(369) and not limit to risk of breast cancer, liver cancer, stroke, gall-bladder disease, thromboembolism(370)(372), cardiovascular disease(371).

A.4. Bone Metabolism Regulator
4.1. Bone Metabolism Regulator including Osteoprotegerin (OPG) are types of human monoclonal antibody medicine used  to prevent RANKL-RANK interaction in bone metabolism through inhibiting osteoclast formation(376)(377), through their effects in reverses osteoporosis(376)(377).
Deficiency of Osteoprotegerin (OPG) reduce function of regulator of postnatal bone mass, decrease in total bone density and induced significant risk of osteoporosis(375).

4.2. Adverse effects of bone metabolism regulator are not limit to pain in the muscles, arms, legs or back and a skin condition with itching, redness and/or dryness. and to the risks of
arterial stiffness(373)(374) and cardiovascular diseases(373) such as atherosclerosis(374)

A.5.  Parathyroid hormone (PTH)
5.1. Parathyroid hormone (PTH) is a hormone released by the parathyroid gland with the function in raising levels of calcium in the blood stream.
In postmenopausal osteoporosis, abaloparatide, a human parathyroid hormone-related peptide analog increased BMD of the lumbar spine, femoral neck, and total hip in a dose-dependent manner, according to the study lead by the Harvard Medical School(378). Once-daily injections of parathyroid hormone have a prominat result in patient with osteoporosis, according to the research team lead by DR. Neer RM., decreased the risk of vertebral and nonvertebral fractures and increased vertebral, femoral, and total-body bone mineral density(379) as well as significantly improved BMD of lumbar spine, total hip, and femoral neck(380).

5.2. Adverse effects are not limit to dizziness, nausea and leg cramps and the risk of hypercalcemia, worsen secondary hyperparathyroidism (SHPT)(381), bone tumors(382).


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study by Dai SM1, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM.(PubMed)
(2) Musculoskeletal Disorders in the Elderly by Ramon Gheno, Juan M. Cepparo, Cristina E. Rosca,1 and Anne Cotten(PMC)
(3) Osteoporosis(Life extension)
(4) Hormone and bone by Francisco Bandeira1, Marise Lazaretti-Castro2, John P. Bilezikian3
(5) Growth hormone and bone by Ohlsson C1, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC.(PubMed)
(6) GH and bone--experimental and clinical studies by Isaksson OG1, Ohlsson C, Bengtsson BA, Johannsson G.(PubMed)
(350) Drug treatment(Osteoporosis Canada)
(351) A comparative study between intravenous and oral alendronate administration for the treatment of osteoporosis by Horikawa A1, Miyakoshi N2, Shimada Y2, Sugimura Y1, Kodama H1.(PubMed)
(352) Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays by Brown JP1, Morin S, Leslie W, Papaioannou A, Cheung AM, Davison KS, Goltzman D, Hanley DA, Hodsman A, Josse R, Jovaisas A, Juby A, Kaiser S, Karaplis A, Kendler D, Khan A, Ngui D, Olszynski W, Ste-Marie LG, Adachi J.(PubMed)
(353) Long-term use of bisphosphonates in osteoporosis by Watts NB1, Diab DL(PubMed)
(354) Safety of bisphosphonates by Orozco C1, Maalouf NM.(PubMed)
(355) Ocular side effects associated with bisphosphonates by Fraunfelder FW1.(PubMed)
(356) Do bisphosphonates reduce the risk of osteoporotic fractures? An evaluation of the evidence to date by Hodsman AB1, Hanley DA, Josse R.(PMC)
(357) Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays.
Brown JP1, Morin S, Leslie W, Papaioannou A, Cheung AM, Davison KS, Goltzman D, Hanley DA, Hodsman A, Josse R, Jovaisas A, Juby A, Kaiser S, Karaplis A, Kendler D, Khan A, Ngui D, Olszynski W, Ste-Marie LG, Adachi J.(PubMed)
(358) Negative spinal bone mineral density changes and subclinical ovulatory disturbances--prospective data in healthy premenopausal women with regular menstrual cycles.
Li D1, Hitchcock CL, Barr SI, Yu T, Prior JC.(PubMed)
(359) Timing of follow-up densitometry in hormone replacement therapy users for optimal osteoporosis prevention by Checa MA1, Del Rio L, Rosales J, Nogués X, Vila J, Carreras R.(PubMed)
(360) Oral versus transdermal hormone replacement therapy by Stevenson JC1, Crook D, Godsland IF, Lees B, Whitehead MI.(PubMed)
(361) Ten reasons to be happy about hormone replacement therapy: a guide for patients by Studd J1.(PubMed)
(362) Hormone therapy and risk of venous thromboembolism among postmenopausal women by Canonico M1, Scarabin PY.(PubMed)
(363) Does hormone replacement therapy and use of oral contraceptives increase the risk of non-melanoma skin cancer? by Birch-Johansen F1, Jensen A, Olesen AB, Christensen J, Tjønneland A, Kjær SK.(PubMed)
(364) Hormone therapy administration in postmenopausal women and risk of stroke by Renoux C1, Suissa S.(PubMed)
(365) Complementary medicine on side-effects of adjuvant hormone therapy in patients with breast cancer by Beuth J1, van Leendert R, Schneider B, Uhlenbruck G.(PubMed)
(366) Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis by Gallagher JC, Riggs BL, DeLuca HF.(PubMed)
(367) Vasomotor symptoms in menopause: physiologic condition and central nervous system approaches to treatment by Rapkin AJ1.(PubMed)
(368) Low-dose estrogen therapy for prevention of osteoporosis: working our way back to monotherapy by Richman S1, Edusa V, Fadiel A, Naftolin F.(PubMed)
(370) Adverse effects of estrogen therapy in a subset of women with ITP by Onel K, Bussel JB.(PubMed)
(371) Adverse effects during endocrine therapy for prostatic carcinoma with a high dose of estrogen by Shinkawa T, Ohfuji T, Osada Y, Ishisawa N.(PubMed)
(372) Oral contraceptives and menopausal hormone therapy: relative and attributable risks of cardiovascular disease,cancer, and other health outcomes by Bassuk SS1, Manson JE2.(PubMed)
(373) Bone metabolism regulators and arterial stiffness in postmenopausal women by Albu A1, Fodor D, Bondor C, Crăciun AM.(PubMed)
(374) Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease by Tousoulis D1, Siasos G, Maniatis K, Oikonomou E, Kioufis S, Zaromitidou M, Paraskevopoulos T, Michalea S, Kollia C, Miliou A, Kokkou E, Papavassiliou AG,Stefanadis C.(PubMed)
(375) osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification by Bucay N1, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, Simonet WS.(PubMed)
(376) Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis by Min H1, Morony S, Sarosi I, Dunstan CR, Capparelli C, Scully S, Van G, Kaufman S, Kostenuik PJ, Lacey DL, Boyle WJ, Simonet WS.(PubMed)
(377) Osteoprotegerin: a physiological and pharmacological inhibitor of bone resorption by Kostenuik PJ1, Shalhoub V.(PubMed)
(378) Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density inpostmenopausal women with osteoporosis by Leder BZ1, O'Dea LS, Zanchetta JR, Kumar P, Banks K, McKay K, Lyttle CR, Hattersley G.(PubMed)
(379) Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis by Neer RM1, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH(PubMed)
(380) Single and combined use of human parathyroid hormone (PTH) (1-34) on areal bone mineral density (aBMD) inpostmenopausal women with osteoporosis: evidence based on 9  RCTs by Song J1, Jin Z1, Chang F1, Li L1, Su Y1.(PubMed)
(381) Effects of Denosumab and Calcitriol on Severe Secondary Hyperparathyroidism in Dialysis Patients With Low Bone Mass by Chen CL1, Chen NC1, Liang HL1, Hsu CY1, Chou KJ1, Fang HC1, Lee PT1.(PubMed)
(382) MiR-125b inhibits stromal cell proliferation in giant cell tumor of bone by targeting parathyroid hormone 1 receptor by Wu PF1, Liang JY1, Yu F1, Zhou ZB1, Tang JY1, Li KH1(PubMed)

Thursday, 10 December 2015

Most Common Diseases of elder: The Clinical Trials and Studies of Musculo-Skeletal disorders: Osteoporosis - The Natural Plantbased Phytochemicals

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                Osteoporosis

Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. It is a widespread degenerative disease of skeletal joints and often associated with senescence in vertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(6).



                               The Prevention and Management 
The prevention and management of osteoporosis are always important due to the prevalent of the diseases in  in all populations and all ages(221), especially to elder, causing a significant physical, psychosocial, and financial consequences(220).

The  Phytochemicals
Phytochemicals found in plants, especially on their skins, play an important and biological role in human health protection and against many forms of diseases(333). According to the animal and cellular studies by Royal Botanic Gardens, phytochemicals found in dried plum and citrus and berry fruits and dietary phytochemicals exhibited a positive association of reduced risk of osteoporosis(334) through improved BMD, microarchitecture integrity, and bone strength(334).
1. Flavonoid
 Flavonoid, a group of phytochemicals, including catechin, and the main ingredient of green tea, have found to process certtain anti diseases and health protective effects, including cardiovascular disease (CVD), cancer and diabetes, epidemiologically(335). (-)-Epigallocatechin, epigallocatechin found in Drynariae rhizoma improved bone metabolism, anti-osteoporiotic activities(336) and resorptive action in bone cells(337).through extraction efficacy of polyphenolic compounds in antioxidant activity(336), the Health Care Products Research Laboratories and Dongguk University College of Oriental Medicine(337) suggested.
In deed, the reduction of oxidative stress or chronic low-grade inflammation by phytochemicals such as flavonoids is associated positively between total dietary intake and bone mineral density(338).

2. Phenolics
Phenolics found abundantly in fruits, especially in the skin, including anthocyanins and stilbenoids,.. may be a potential phytochemicals in decreased the imbalance of bone turn over on bone metabolism induced risk of osteoporosis(339). According to the Guangdong Medical College study, phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis, exhibited anti-osteoporosis effects through reduction of oxidative stress involved bone formation by osteoblastic cells(340) in rat.
In comparison between pre- and postmenopausal women for effectiveness of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract the Safety and Bioactivity of Plant Foods suggested that intake of olive phenolics mayprevent age-related and oxidative stress-related osteoporosis(341),

4. Curcumin
Curcumin a diarylheptanoid of turmeric, is a member of the ginger family (Zingiberaceae) and best known for its antioxidant effects in enhancing the immune system for fighting of the forming of free radicals and foreign invasion of that induced acute and chronic diseases(342). Some researcher has suggested to use curcumin for treatment of various musculoskeletal disorders, such as osteoarthritis, osteoporosis, musculocartilaginous disorders,... due to its efficacy as antioxidant with a significant medicinal properties, such as anti-inflammatory and anti-neoplastic activities(344).
In glucocorticoid-induced osteoporosis, administration of curcumin in dose dependent-manner promote over all bone health by increased BMD and bone-alkaline phosphatase, decreased carboxy-terminal collagen cross links, enhanced bone mechanical strength, and improved trabecular microstructure, according to Shengjing Hospital of China Medical University in rat study(343).
The analytic study of the combination of conjugated GNPs (CGNPs), which can form inclusion complexes with curcumin (CUR-CGNPs) has also found to process a significantly improved bone density and prevented bone loss activities through inhibiting osteoclast (OC) formation and osteoclastogenesis in bone marrow-derived macrophages(345).
 
5. Phloridzin
Phloridzin, another antioxidant found mainly in apple has found to process anti high blood glucose levels and improve lipids metabolism in animal model(346). According to the Unité des Maladies Métaboliques et Micronutriments, in aging induced change of sex hormones related of that lead to inflammatory and oxidant condition, phloridzin prevented imflammatory condition in ovariectomy-induced bone loss, and improved bone resorption(347).

6. Pectin
Pectin, is a structural heteropolysaccharide found mainly in the in the primary cell walls of  terrestrial plants. Pectin Rhamnogalacturonan-Is (RG-Is) isolated from potato and apple may be an important phytochemical in increased osteoprotective effects mediated via antioxidant or anti-inflammatory pathways and their downstream signaling mechanisms(349), such as in increased mineralized matrix formation of osteoblastic cells through production of high amount of galactan in vitro, according to joint study lead by Copenhagen University Hospital Glostrup(348).

Due to proven effects of phytochemicals  in bone health, there is a suggestion in determination of scientist to provide the effective doses of phytochemicals and their metabolites in improving bone mass, microarchitecture integrity, and bone strength of that may reduce the occurrence of osteoporosis(349).

Ovarian Cysts And PCOS Elimination

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References
(1) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study by Dai SM1, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM.(PubMed)
(2) Musculoskeletal Disorders in the Elderly by Ramon Gheno, Juan M. Cepparo, Cristina E. Rosca,1 and Anne Cotten(PMC)
(3) Osteoporosis(Life extension)
(5) Growth hormone and bone by Ohlsson C1, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC.(PubMed)
(6) GH and bone--experimental and clinical studies by Isaksson OG1, Ohlsson C, Bengtsson BA, Johannsson G.(PubMed)
(205) New advances in imaging osteoporosis and its complications by Griffith JF1, Genant HK.(PubMed)
(207) Severe osteoporosis: diagnosis of non-hip non-vertebral (NHNV) fractures by Giovanni D’Elia,1 Giuliana Roselli,1 Loredana Cavalli,2 Paolo Innocenti,1 and Maria Luisa Brandi2(PubMed)
(208) Whole bone geometry and bone quality in distal forearm fracture by Parkinson IH1, Fazzalari NL.(PubMed)
(209) Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density inosteoporosis by Shiraki M1, Shiraki Y, Aoki C, Miura M.(PubMed)
(210) Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase ofbone turnover in postmenopausal osteoporosis: a randomized prospective study by Shiraki M1, Itabashi A.(PubMed)
(211) Association of Body Weight and Body Mass Index with Bone Mineral Density in Women and Men from Kosovo by Rexhepi S1, Bahtiri E2, Rexhepi M1, Sahatciu-Meka V3, Rexhepi B1.(PubMed)
(212) Should we prescribe calcium or vitamin D supplements to treat or prevent osteoporosis? by Bolland MJ1, Grey A1, Reid IR1.(PubMed)
(333) The role of phytochemicals as micronutrients in health and disease by Howes MJ1, Simmonds MS.(PubMed)
(334) Fruits and dietary phytochemicals in bone protection by Shen CL1, von Bergen V, Chyu MC, Jenkins MR, Mo H, Chen CH, Kwun IS.(PubMed)
(335) The role of phytochemicals as micronutrients in health and disease by Howes MJ1, Simmonds MS.(PubMed)
(336) In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts. by Kang SN1, Lee JS2, Park JH3, Cho JH4, Park JH5, Cho KK6, Lee OH7, Kim IS8.(PubMed)
(337) Inhibitory activity of Drynariae rhizoma extracts on cathepsin having bone resorption activity.by Jeong JC1, Yoon CH, Jeong CW, Lee YC, Chang YC, Kim CH.(PubMed)
(338) The effects of flavonoids on bone by Welch AA1, Hardcastle AC.(PubMed)
(339) In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts by Kang SN1, Lee JS2, Park JH3, Cho JH4, Park JH5, Cho KK6, Lee OH7, Kim IS8.(PubMed)
(340) The phenolics from the roots of Livistona chinensis show antioxidative and obsteoblast differentiation promoting activity by Zeng X1, Tian J2, Cui L3, Wang Y4, Su Y5, Zhou X6, He X7.(PubMed)
(341) Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre- and postmenopausal women by García-Villalba R1, Larrosa M, Possemiers S, Tomás-Barberán FA, Espín JC.(PubMed)
(342) Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases by Bengmark S1.(PubMed)
(343) Curcumin alleviates glucocorticoid-induced osteoporosis by protecting osteoblasts from apoptosis in vivo and in vitro by Chen Z1, Xue J2, Shen T1, Ba G1, Yu D1, Fu Q1.(PubMed)
(344) Role of Curcumin in Common Musculoskeletal Disorders: a Review of Current Laboratory, Translational, and Clinical Data by Peddada KV1, Peddada KV2, Shukla SK3, Mishra A3, Verma V4.(PubMed)
(345)Inhibition of osteoclast differentiation by gold nanoparticles functionalized with cyclodextrin curcumincomplexes by Heo DN1, Ko WK, Moon HJ, Kim HJ, Lee SJ, Lee JB, Bae MS, Yi JK, Hwang YS, Bang JB, Kim EC, Do SH, Kwon IK.(PubMed)
(346) Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats by Najafian M1, Jahromi MZ, Nowroznejhad MJ, Khajeaian P, Kargar MM, Sadeghi M, Arasteh A.(PubMed)
(347) Prevention of bone loss by phloridzin, an apple polyphenol, in ovariectomized rats under inflammation conditions by Puel C1, Quintin A, Mathey J, Obled C, Davicco MJ, Lebecque P, Kati-Coulibaly S, Horcajada MN, Coxam V.(PubMed)
(348) Osteoblastic response to pectin nanocoating on titanium surfaces by Gurzawska K1, Svava R2, Yihua Y3, Haugshøj KB3, Dirscherl K4, Levery SB5, Byg I6, Damager I7, Nielsen MW8, Jørgensen B6, Jørgensen NR9, Gotfredsen K10.(PubMed)
(349) Fruits and dietary phytochemicals in bone protection by Shen CL1, von Bergen V, Chyu MC, Jenkins MR, Mo H, Chen CH, Kwun IS.(PubMed)

Wednesday, 9 December 2015

Most Common Diseases of elder: The Clinical Trials and Studies of Musculo-Skeletal disorders: Osteoporosis - The antioxidant enzymes

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                Osteoporosis

Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. It is a widespread degenerative disease of skeletal joints and often associated with senescence in vertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(6).



                               The Prevention and Management 
The prevention and management of osteoporosis are always important due to the prevalent of the diseases in  in all populations and all ages(221), especially to elder, causing a significant physical, psychosocial, and financial consequences(220).

                                 Antioxidants and Osteoporosis

Oxidative stress can induce impairment of bone mass and fragility fractures through its effects in causing apoptosis in osteoblasts, due to continuously generated of reactive oxygen species (ROS), such as H2O2-induced oxidative damage-implications(246) involved lipid peroxidation, protein damage, and DNA lesions of that exhibit the increased risk of osteoporosis(245)(248).
Antioxidant enzymes, including superoxide dismutase, glutathione peroxidase, and catalase reduced the excessive production of free radicals in the organism, and the imbalance between the concentrations of these and the antioxidant defenses have found to attenuate the risk of osteoporosis (OP) in postmenopausal women, according to the study by the Adnan Menderes University School of Medicine(247). Further more, decrease antioxidant defenses due to aging may also may contribute to this process(250).
Dietary and endogenous antioxidants were consistently lower in patients with osteoporosis, according to University of Perugia, of that can lead to decrease antioxidant defenses and promoting pathogenesis of osteoporosis(249).

The antioxidant enzymes
1. Superoxide dismutase
Superoxide dismutase, an antioxidant enzyme used minerals as cofactors and named accordingly such as Cu-Zn-SOD, Cu-SOD, Fe-SOD, Mn-SOD have played an important role in reduced oxidative stress form of osteoporosis(326). According to the Sun Yat-sen University, SOD-1 inhibited reactive oxygen species (ROS),promoted the osteogenic differentiation and Improved osteogenic ability(327) and SOD-2, according to the joint study lead by Chiba University Graduate School of Medicine, induce osteocytes causes of age-related bone loss through rescued the impairment of canalicular networks and bone metabolism(328).
Manganese superoxide dismutase(Mn-SOD), in the study by the joint study lead by The Fourth Military Medical University, improved bone homeostasis by maintaining the balance of osteoblasts (OBs) and osteoclasts (OCs)(329).

2. Glutathione peroxidase 
Glutathione peroxidase plays a biological role against oxidative damage may be effective in reduced risk of osteoporosis when usedconjunction with lycopene and other antioxidant enzymes(309). Deterioration of antioxidant enzymes, including glutathione peroxidase, due to aging have found to associate to increased oxidative stress inducing post menopausal osteoporosis(330).

c. Catalase
Catalase like many other antioxidant enzymes found in all living species with a function in reduced damage caused by reactive oxygen species (ROS)(331) may held a keys in preventing the loss of bone mineral density and decreased oxidative stress causes of osteoporotic menopausal women(331).
According to the study by King Abdulaziz University,catalase used conjunction with other antioxidant enzymes and lycopepe showed to suppress bone turnover to restore bone strength(309) of that may reduce risk of bone minerald density loss(309).


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study by Dai SM1, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM.(PubMed)
(2) Musculoskeletal Disorders in the Elderly by Ramon Gheno, Juan M. Cepparo, Cristina E. Rosca,1 and Anne Cotten(PMC)
(3) Osteoporosis(Life extension)
(4) Hormone and bone by Francisco Bandeira1, Marise Lazaretti-Castro2, John P. Bilezikian3
(5) Growth hormone and bone by Ohlsson C1, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC.(PubMed)
(6) GH and bone--experimental and clinical studies by Isaksson OG1, Ohlsson C, Bengtsson BA, Johannsson G.(PubMed)
(221) Osteoporosis prevention, diagnosis, and therapy by [No authors listed](PubMed)
(245) Protein Phosphatase 2A Mediates Oxidative Stress Induced Apoptosis in Osteoblasts by Huang CX1, Lv B1, Wang Y1.(PubMed)
(246) Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis by Xu ZS1, Wang XY, Xiao DM, Hu LF, Lu M, Wu ZY, Bian JS.(PubMed)
(247) Antioxidant status in patients with osteoporosis: a controlled study by Sendur OF1, Turan Y, Tastaban E, Serter M.(PubMed)
(248) Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis by Ozgocmen S1, Kaya H, Fadillioglu E, Aydogan R, Yilmaz Z.(PubMed)
(249) Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study by Maggio D1, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A.(PubMed)
(250) Alterations of antioxidant enzymes and oxidative stress markers in aging by Kasapoglu M1, Ozben T.(PubMed)
(222) Eating Guidelines to Prevent Osteoporosis - It's Never Too Late! by dietitian of Canada


(273) Influence of the forms and levels of dietary selenium on antioxidant status and oxidative stress-related parameters in rainbow trout (Oncorhynchus mykiss) fry by Fontagné-Dicharry S1, Godin S2, Liu H1, Antony Jesu Prabhu P1, Bouyssière B2, Bueno M2, Tacon P3, Médale F1, Kaushik SJ1.(PubMed)
(274) The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus by Biller-Takahashi JD1, Takahashi LS2, Mingatto FE3, Urbinati EC4.(PubMed)
(275) Selenium combined with vitamin E and vitamin C restores structural alterations of bones in heparin-inducedosteoporosis by Turan B1, Can B, Delilbasi E(PubMed)
(276) Dietary products consumption in relation to serum 25-hydroxyvitamin D and selenium level in Saudi children and adults by Al-Daghri NM1, Al-Attas O1, Yakout S1, Aljohani N2, Al-Fawaz H3, Alokail MS1.(PubMed)
(277) Simultaneous subchronic exposure to selenium and diazinon as possible risk factor for osteoporosis in adult male rats by Martiniaková M, Boboňová I, Omelka R, Grosskopf B1, Chovancová H, Spanková J, Toman R.(PubMed)
(278) Structural changes in femoral bone tissue of rats after subchronic peroral exposure to selenium by Martiniaková M1, Boboňová I, Omelka R, Grosskopf B, Stawarz R, Toman R.(PubMed)
(279) The protective effect of calcium on bone mass in postmenopausal women with high selenium intake by Pedrera-Zamorano JD1, Calderon-García JF, Roncero-Martin R, Mañas-Nuñez P, Moran JM, Lavado-Garcia JM.(PubMed)
(280) In vitro degradability, bioactivity and primary cell responses to bone cements containing mesoporousmagnesium-calcium silicate and calcium sulfate for bone regeneration by Ding Y1, Tang S1, Yu B2, Yan Y3, Li H3, Wei J4, Su J5.(PubMed)
(281) In vitro degradability, bioactivity and primary cell responses to bone cements containing mesoporous magnesium–calcium silicate and calcium sulfate for bone regeneratio by Yueting Ding, Songchao Tang, Baoqing Yu, Yonggang Yan, Hong Li, Jie Wei, Jiacan Su(The Royral Society)
(282) Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study by Orchard TS1, Larson JC, Alghothani N, Bout-Tabaku S, Cauley JA, Chen Z, LaCroix AZ, Wactawski-Wende J, Jackson RD.(PubMed)
(283) Bone. Maximizing bone health--magnesium, BMD and fractures by Nieves JW1.(PubMed)
(284) [Nutrition and bone health. Magnesium and bone].[Article in Japanese] by Ishimi Y1.(PubMed)
(285) The standardized creation of a lumbar spine vertebral compression fracture in a sheep osteoporosis model induced by ovariectomy, corticosteroid therapy and calcium/phosphorus/vitamin D-deficient diet by Eschler A1, Röpenack P2, Herlyn PK2, Roesner J3, Pille K2, Büsing K4, Vollmar B5, Mittlmeier T2, Gradl G6.(PubMed)
(286) Low vitamin D, and bone mineral density with depressive symptoms burden in menopausal and postmenopausalwomen by Bener A1, Saleh NM2.(PubMed)
(287) Calcium and vitamin D nutrition and bone disease of the elderly by Gennari C1.(PubMed)
(288) Prevention of hip fractures by correcting calcium and vitamin D insufficiencies in elderly people. by Meunier P1.(PubMed)
(289) Screening for Vitamin D Deficiency: Systematic Review for the U.S. Preventive Services Task Force Recommendation [Internet] by LeBlanc E, Chou R, Zakher B, Daeges M, Pappas M.(PubMed)
(290) Vitamin D and intestinal calcium absorption by Christakos S1, Dhawan P, Porta A, Mady LJ, Seth T.(PubMed)
(291) Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women by Mahdavi-Roshan M1, Ebrahimi M2, Ebrahimi A3.(PubMed)
(292) Magnesium, zinc and copper status in osteoporotic, osteopenic and normal post-menopausal women by Mutlu M1, Argun M, Kilic E, Saraymen R, Yazar S.(PubMed)
(293) Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis by Zheng J1, Mao X, Ling J, He Q, Quan J.(PubMed)
(294) Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis. Can magnesium play a key role in osteoporosis? by Odabasi E1, Turan M, Aydin A, Akay C, Kutlu M.(PubMed)
(295) Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies by Samsel A1, Seneff S2.(PubMed)
(296) Effects of manganese deficiency on the microstructure of proximal tibia and OPG/RANKL gene expression in chicks by Liu R1, Jin C, Wang Z, Wang Z, Wang J, Wang L.(PubMed)
(297) Higher Dietary Acidity is Associated with Lower Bone Mineral Density in Postmenopausal Iranian Women, Independent of Dietary Calcium Intake by Shariati-Bafghi SE1, Nosrat-Mirshekarlou E, Karamati M, Rashidkhani B.(PubMed)
(298) Role of nutritional zinc in the prevention of osteoporosis by Yamaguchi M1.(PubMed)
(299) Nutritional factors and bone homeostasis: synergistic effect with zinc and genistein in osteogenesis by Yamaguchi M1(PubMed)
(300) Implications of compromised zinc status on bone loss associated with chronic inflammation in C57BL/6 mice by Chongwatpol P1, Rendina-Ruedy E1, Stoecker BJ1, Clarke SL1, Lucas EA1, Smith BJ1.(PubMed)
(301) Zinc deficiency exaggerates diabetic osteoporosis by Fushimi H1, Inoue T, Yamada Y, Horie 
(302) Sodium fluoride therapy of postmenopausal osteoporosis. by Kleerekoper M1, Mendlovic DB.(PubMed)
(303) Comparison of nonrandomized trials with slow-release sodium fluoride with a randomized placebo-controlled trial in postmenopausal osteoporosis by Pak CY1, Adams-Huet B, Sakhaee K, Bell NH, Licata A, Johnston C, Rubin B, Bonnick S, Piziak V, Graham H, Ballard J, Berger R, Fears W, Breslau N, Rubin C.(PubMed)
(304) Slow-release sodium fluoride in the management of postmenopausal osteoporosis. A randomized controlled trial by Pak CY1, Sakhaee K, Piziak V, Peterson RD, Breslau NA, Boyd P, Poindexter JR, Herzog J, Heard-Sakhaee A, Haynes S, Adams-Huet B, Reisch JS.(PubMed)
(305) Treatment of postmenopausal osteoporosis with slow-release sodium fluoride. Final report of a randomized controlled trial by Pak CY1, Sakhaee K, Adams-Huet B, Piziak V, Peterson RD, Poindexter JR.(PubMed)