The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine: TCM Spleen Qi deficiency - Herbal Peony (Chi Shao)

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Treatments in Traditional Chinese Herbal Medicine

B.3.3. Spleen Qi deficiency
Spleen is a vital organ, according to traditional Chinese medicine, with function in absoring nutrients and transporting them to body's organs and cells. Spleen Qi deficiency is a condition of the inability of the spleen in maximized transportation of nutrients to body organs, including the brain. Prolong period of malnutrition of brain cells may induce abnormal functions in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842) and changes in brain tissues and behavior patterns(843)(842).

Herbal medicine for Spleen Qi deficiency
1. Peony (Chi Shao)
Chi Shao or Chi Shao Yao with bitter, sour taste and cool in nature is also known as Peony Root, used in TCM as antispasmodic(1000)(1001), anti-inflammatory(1002)(1003), anti allergic(1004) antibiotic(1005), anticonvulsant(1006), analgesic(1007), anxiolytic(1008) agents and to lower blood pressure(1009), dilate peripheral blood vessels, coronary arteries against heart attack(1010), treat viral hepatitis(1011), chronic constipation(1012), asthma(1013), whooping cough(1014), diabetes(1015)(1016), etc., as it clears heat, cools blood, eliminates blood accumulation, calms paindilates, etc., by enhancing the functions of liver and spleen channels(1017).
Phytochemicals
1. Essential oil
2. Resin
3. Paeoniflorin
4. Paeonol
5. Paeonin
6. Albiflorin
7. Triterpenoids
8. Sistosterol
9. Oxypaeoniflorin
10. Benzoylpaeoniflorin
11. Benzoic acid
12. β sitosterol
13. Gallotannin
14. Pedunculagin
15. 1-O-Galloylpedunculagin
16. Eugeniin
17. Tannin acid
18. Etc.

Herbal shao yao used in traditional Chinese medicine for treatment and prevention of dementia(1018)(1019), may be due to its effectiveness of phytochemicals, including major constituent paeoniflorin, in exertion of its neuroprotective effects(1020)(1021) through anti oxidative stress(1022), anti inflammatory(1023), improved neural synapse plasticity(1024) mechanisms, against β-amyloid (Aβ) accumulation(1025) induced senile dementia and aging-induced cognitive dysfunction(1026).

1.1. Parkinson's disease PD
Strong evidences suggested that peony, possesses wide pharmacological effects in nervous system(1027)(1028). Paeoniflorin, a phytochemical isolated from peony, in PC12 cells induced by 6-OHDA found in patient with Parkinson's disease(1030), showed to suppress mitochondria apoptosis, through its antioxidant capability in increasing glutathione (GSH)(1032), by inhibiting reactive oxygen species (ROS)(1031). In Parkinson's disease (PD) progressive loss of dopaminergic neurons involved movement and in mouse model with mitochondrial dysfunction, peony significantly inhibited mitochondria-mediated apoptosis, via the regulation of expression of immunity, inhibition of cytochrome C associated with the inner membrane of the mitochondrion. release and caspase-3, a protein encoded by in CASP3gene, activation(1031). According to University of Miami, polyphenols of bai shao, included baicalin, baicalein, wogonin (in scutellaria) paeonol, paeonoside, and paeoniflori, exerted neuroprotective efficacy, probably through improving cerebral blood circulation, involved alleviation of the symptoms of degenerative diseases, Alzheimer's disease (AD) andParkinson's disease (PD)(1033).

1.2. In Alzheimer's disease AD
Abeta42 deposition in hippocampus has shown to induce brain inflammation causes of early onset of Alzheimer's disease AD(1034)(1035). Paeonol(2'-hydroxy-4'-methoxyacetophenone;1-(2-hydroxy-4-methoxyphenyl)ethan-1-one), found in peony, not only protected the nervous system against accumulation of amyloid peptide, Aβ1-42, through its anti-inflammatory and free radical scavenging properties, but also slowed down and regulated the pathogenic processes associated with AD, through morphological, biochemical and behavioral activities(1036). Aqueous extract of the dry root ofPeony in Abeta((1-42))-induced rats, also inhibited Abeta-induced neurotoxicity, through ameliorated cognitive deficit, cell apoptosis in dose-dependent manner(1037).

1.3. In cognitive impairment
Cognitive impairment is common in patients with the neurodegenerative disease, including Alzheimer's disease (AD) and Parkinson's disease (PD, Paeoniflorin, isolated from the aqueous extract of peony, in rat model, not only showed to promote the cognitive ability, exhibited anti-depressant-like effect and reduced toxicity, but also attenuated the oxidative stress induced Aβ(1-42) by regulating choline acetyltrasferase and the activity of acetylcholine esterase in the hippocampus of Aβ(1-42)(1038)(1039). In Chronic cerebral hypoperfusion, associated with the cognitive deficits of AD, the phytochemical also attenuated cognitive deficit and brain damage through ameliorated astrocytes(star-shaped glial cells in CNS) and microglias(glial cell in CNS) in hippocampus(1040). According to Shanghai Institute of Materia Medica, on cerebral infarction induced neurological symptoms, paeoniflorin (PF) significantly reduced the infarct volume causes of cognitive impairment(1041).

1.4. In learning and memory
Supplementation of paeonol extracted from peony, in d-galactose (D-gal)-induced aging mice, significantly improved the learning and memory ability through reduction of oxidative stress, cognitive impairment and neurotoxicity, according to China Pharmaceutical University(1042). Danggui-Shaoyao-San (DSS), the herbal formula containing peony and 5 other herbs, used to treat gynecological disorders and neural dysfunctions, in the same model study, showed effectively in improved cognitive ability, through ameliorating oxidative stress induced neuronal apoptosis in the brain(1043). Paeoniflorin, a major constituent of peony, also exhibited its beneficial effect on learning and memory impairment in rodents, by reversed the suppressible effects of adenosine as shown on passive avoidance test and inhibition of long-term potentiation (LTP)(1044).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)

(1002) Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inflammation by Fu PK1, Yang CY, Tsai TH, Hsieh CL.(PubMed)

(1003) Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activity by Li H1, Dai M, Jia W.(PubMed)

(1004) Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. by Lee B1, Shin YW, Bae EA, Han SJ, Kim JS, Kang SS, Kim DH.(PubMed)

(1005) Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori by Ngan LT1, Moon JK, Shibamoto T, Ahn YJ.(PubMed)

(1006) Peony root extract upregulates transthyretin and phosphoglycerate mutase in mouse cobalt focus seizure by Kajiwara K1, Sunaga K, Tsuda T, Sugaya A, Sugaya E, Kimura M.(PubMed)

(1007) Clinical efficacy of aconitum-containing traditional Chinese medicine for diabetic peripheral neuropathic pain by Feng L1, Liu WK, Deng L, Tian JX, Tong XL.(PubMed)

(1008) Anxiolytic-like effect of paeonol in mice. by Mi XJ1, Chen SW, Wang WJ, Wang R, Zhang YJ, Li WJ, Li YL.(PubMed)

(1009) [Effects of yishenjiangyafang on blood pressure and protecting renal function in RPH rats].[Article in Chinese] by Chen ML1, Liu WJ, Wang CY, Zhu XM, Yin JF, Wang DX, Liu P.(PubMed)

(1010) The protective effect of peony extract on acute myocardial infarction in rats by Mo X1, Zhao N, Du X, Bai L, Liu J.(PubMed)

(1011) Paeoniflorin protects against concanavalin A-induced hepatitis in mice. by Chen M1, Cao L2, Luo Y3, Feng X4, Sun L5, Wen M6, Peng S7.(PubMed)

(1012) [Treatment of irritable bowel syndrome by Chinese medicine and pharmacy: an analysis of data mining on experiences of experts].[Article in Chinese] by Zhang BH1, Gao R, Li ZH, Li BS, Wang FY, Tang XD.(PubMed)

(1013) Antioxidant and anti-inflammatory effects of Schisandra and Paeonia extracts in the treatment of asthma by Chen X1, Huang Y1, Feng J1, Jiang XF1, Xiao WF1, Chen XX1.(PubMed)

(1014) The effect of a traditional Chinese prescription for a case of lung carcinoma by Kamei T1, Kumano H, Iwata K, Nariai Y, Matsumoto T.(PubMed)

(1015) [Effect of a peony root preparation on the status of the insulin and hemostatic system in animals during development of alloxan diabetes].[Article in Russian] by Ul'ianov AM, Tarasov IuA, Liapina LA, Pastorova VE, Uspenskaia MS.(PubMed)

(1016) Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice by Kim JJ1, Choi J1, Lee MK2, Kang KY3, Paik MJ3, Jo SK4, Jung U4, Park HR4, Yee ST5.(PubMed)

(1017) Shao Yao(Complementary and Alternative Healing University)

(1018) Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin by Liu J1, Wang JS, Kong LY.(PubMed)

(1019) A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo by Fujiwara H1, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M,Yaegashi N, Kase Y, Arai H.(PubMed)

(1020) Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists by Liu DZ1, Xie KQ, Ji XQ, Ye Y, Jiang CL, Zhu XZ.(PubMed)

(1021) Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells by Wang D1, Tan QR, Zhang ZJ.(PubMed)

(1022) Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway.by Dong H1, Li R2, Yu C1, Xu T1, Zhang X1, Dong M3.(PubMed)

(1023) Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling by Liu MH1, Lin AH1, Lee HF2, Ko HK3, Lee TS1, Kou YR1.(PubMed)

(1024) [Advance in studies on effect of paeoniflorin on nervous system].[Article in Chinese] by Hu ZY1, Xu L, Yan R, Huang Y, Liu G, Zhou WX, Zhang YX.(PubMed)

(1025) Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease by Zhou J1, Zhou L, Hou D, Tang J, Sun J, Bondy SC.(PubMed)

(1026) Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task by Ohta H1, Matsumoto K, Shimizu M, Watanabe H.(PubMed)

(1027) [Effects of total paeony glucosides on mRNA expressions of Toll receptors and interleukin-33 in the brain tissue of D-galactose induced aging rats: an experimental research].[Article in Chinese] by Zhang HY1, Liu ZJ, Chen ZW.(PubMed)

(1028) [Advance in studies on effect of paeoniflorin on nervous system].[Article in Chinese] by Hu ZY1, Xu L, Yan R, Huang Y, Liu G, Zhou WX, Zhang YX.(PubMed)

(1028a) Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists by Liu DZ1, Xie KQ, Ji XQ, Ye Y, Jiang CL, Zhu XZ.(PubMed)

(1029) Mechanism of 6-hydroxydopamine neurotoxicity by Glinka Y1, Gassen M, Youdim MB.(PubMed)

(1030) Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway by Dong H1, Li R2, Yu C1, Xu T1, Zhang X1, Dong M3.(PubMed)
(1031) Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease by Kim HG1, Park G2, Piao Y3, Kang MS4, Pak YK3, Hong SP1, Oh MS5.(PubMed)
(1032) Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway by Sun R1, Wang K, Wu D, Li X, Ou Y.(PubMed)
(1033) Polyphenols and neuroprotection against ischemia and neurodegeneration. by Lin B1.(PubMed)
(1034) Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy by Chia-Chen Liu,1 Takahisa Kanekiyo,2 Huaxi Xu,1 and Guojun Bu1(PMC)
(1035) Increased A beta 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene by Ishii K1, Ii K, Hasegawa T, Shoji S, Doi A, Mori H.(PubMed)
(1036) Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease by Lippa CF, Nee LE, Mori H, St George-Hyslop P.(PubMed)
(1037) Peoniflorin attentuates Abeta((1-42))-mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats by Zhong SZ1, Ge QH, Li Q, Qu R, Ma SP.(PubMed)
(1038) A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia by Metzler-Baddeley C1.(PubMed)
(1039) Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats. by Lan Z1, Chen L2, Fu Q1, Ji W1, Wang S1, Liang Z1, Qu R3, Kong L4, Ma S5.(PubMed)
(1040) Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats by Liu J1, Jin DZ, Xiao L, Zhu XZ.(PubMed)
(1041) Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats by Xiao L1, Wang YZ, Liu J, Luo XT, Ye Y, Zhu XZ.(PubMed)
(1042) Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice by Zhong SZ1, Ge QH, Qu R, Li Q, Ma SP.(PubMed)
(1043) Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice by Lan Z1, Liu J, Chen L, Fu Q, Luo J, Qu R, Kong L, Ma S.(PubMed)
(1044) Ameliorative effects of paeoniflorin, a major constituent of peony root, on adenosine A1 receptor-mediated impairment of passive avoidance performance and long-term potentiation in the hippocampus by Tabata K1, Matsumoto K, Murakami Y, Watanabe H.(PubMed)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine: TCM Treatment of Dementia Induced by Heart (Yang) Qi deficiency: Herbal Sang shen

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Treatments in Traditional Chinese Herbal Medicine

B.2. Heart (Yang) Qi deficiency
Heart Qi deficiency is a condition of the inability of the heart in transportation of nutrients to body organs, including the brain through blood circulation. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842), changes in brain tissue and behavior patterns(843)(842).
2.4. Sang shen
Sang Shen also known as Mulberry or Morus Fruit, the sweet, sour and cold herb has been used in TCM as antioxidant(968)(969), antiinflammatory(969), anti ageing(991) and neuroprotective(968)(970) agents and to treat vertigo, tinnitus, insomnia, atherosclerosis(971)(973), vascular smooth muscle cells(972), lipid accumulation(974), weak digestion, premature white hair, thirst(967), diabetes(967), diarrhea, etc., as it nourishes Yin, and Blood, promotes generation of Body Fluid, moistens the Intestines, etc. by enhancing the functions of heart, liver and kidney channels(975).

Phytochemicals
1. Resveratrol
2. Anthocyanosides
3. Carotene
4. Thiamine
5. Ribflavin
6. Vtamin C
7. Vannin
8. Linoleic acid
9. Stearic acid
10. Etc.

Herbal sang shen used in the treatment and prevention of dementia(977) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in exertion of its neuroprotective effects(968)(970) through anti oxidative stress(968)(969), anti inflammatory(969) and anti excitotoxic (involved Alzheimer's disease) mechanisms(978) against cell membrane damage and mitochondrial function induced by oxygen-glucose deprivation (OGD) and glutamate-induced cell death(977).

1. In aging Alzheimer's disease(ADs)
Decreased the levels of serum aspartate aminotransferase caused by oxidative stress(979), alanine aminotransferase(980), triglyceride(981) and total cholesterol(982) due to ageing have shown to involve in the development of Alzheimer's disease. In ageing animals, mulberry extracts (ME), rich in phenolics and anthocyanins, significantly demonstrated less amyloid beta protein and improved learning and memory ability through its antioxidant enzymes and reduction of oxidative damage(983).
Cyanidin-3-glucoside (C3G) fraction extracted from sang shen effectively protected primary cortical neurons in 7 days, against glutamate-induced cell death cause of dementia, including Alzheimer's disease(ADs(978) in rat model(984).

2. In Parkinson's disease
Parkinson's disease (PD), is one of the most common neurodegenerative disorders as results of dopaminergic deafferentation of the basal ganglia)(985) and oxidative stress(986)(987).
According to Kyung Hee University, 70 % ethanol extract of mulberry fruit(ME), in dose-dependent manner, in vitro and in vivo PD models showed to prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neuronal damage(999), through its antioxidant and anti-apoptotic effects, in regulating reactive oxygen species and NO generation(988).

3. Neuroprotective effects
Cyanidin-3-O-beta-d-glucopyranoside (C3G) found abundantly in the mulberry fruits exerted significantly exhibited its cytoprotective effect on PC12 cells(derived from a pheochromocytoma of the rat adrenal medulla) under oxidative stress induced neuro-degenerative diseases(983)(989). In neurological disorders, including Alzheimer's and Parkinson's diseases, caused by cerebral ischemia, mulberry leaves (ML) exhibited neuroprotectiveactions in reduced the cytotoxicity in the PC12 cells against oxygen glucose deprivation with enhanced accumulation of gamma-aminobutyric acid (GABA)(990).

4. In memory improvement
In mice model, mulberry fruits extract, significantly increased pre- and post-synapse formation(992), acetylcholine synthesisation(993), neuronal cell differentiation(994), neurite outgrowth(995) and neuronal cell proliferation(996) in the hippocampus, against loss of memory through its antioxidant in protecting or enhanced neuronal functions mediated by neurotrophic factors, such as nerve growth factor (NGF)(991). According to National Chung Hsing University, in memory deterioration in ageing animals, phenolics and anthocyanins, from mulberry fruits, inhibited amyloid beta protein(998) and improved learning and memory ability through induced higher antioxidant enzyme activity and less lipid oxidation in both the brainand liver(997).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References

(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)

(968) Mulberry extracts alleviate aβ 25-35-induced injury and change the gene expression profile in PC12 cells. by Song N1, Yang H2, Pang W3, Qie Z3, Lu H4, Tan L3, Li H3, Sun S3, Lian F5, Qin C6, Jiang Y3.(PubMed)
(969) Combined treatment of mulberry leaf and fruit extract ameliorates obesity-related inflammation and oxidative stress in high fat diet-induced obese mice by Lim HH1, Yang SJ, Kim Y, Lee M, Lim Y.(PubMed)
(970) [Primary study on protective effect of mulberry extracts on Abeta25-35-induced PC12 cells injury].[Article in Chinese] by Song N1, Pang W, Yang H, Tan L, Fu J, Li H, Jiang Y.(PubMed)
(971) Mulberry water extracts inhibit rabbit atherosclerosis through stimulation of vascular smooth muscle cell apoptosis via activating p53 and regulating both intrinsic and extrinsic pathways by Chan KC1, Ho HH, Lin MC, Wu CH, Huang CN, Chang WC, Wang CJ.(PubMed)
(972) Impact of polyphenolic components from mulberry on apoptosis of vascular smooth muscle cells by Chan KC1, Ho HH, Lin MC, Huang CN, Huang HP, Wang CJ.(PubMed)
(973) Effects of Panax notoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells by Xu L1, Liu JT, Liu N, Lu PP, Pang XM.(PubMed)
(974) Blueberry and mulberry juice prevent obesity development in C57BL/6 mice by Wu T1, Tang Q, Gao Z, Yu Z, Song H, Zheng X, Chen W.(PubMed)
(975) Sang Shen(Complementary and Alternative Healing University)
(976) Mulberry Fruit Extract Protects against Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia by Kaewkaen P1, Tong-Un T, Wattanathorn J, Muchimapura S, Kaewrueng W, Wongcharoenwanakit S.(PubMed)

(977) The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation by Bhuiyan MI1, Kim HB, Kim SY, Cho KO.(PubMed)

(978) Slow excitotoxicity in Alzheimer's disease. by Ong WY1, Tanaka K, Dawe GS, Ittner LM, Farooqui AA.(PubMed)

(979) Serum elevated gamma glutamyltransferase levels may be a marker for oxidative stress in Alzheimer's disease. by Yavuz BB1, Yavuz B, Halil M, Cankurtaran M, Ulger Z, Cankurtaran ES, Aytemir K, Ariogul S.(PubMed)

(980) Increased aspartate aminotransferase activity in cerebrospinal fluid and Alzheimer's disease

(981) Effects of caprylic triglyceride on cognitive performance and cerebral glucose metabolism in mild Alzheimer's disease: a single-case observation by Farah BA1.(PubMed)

(982) Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. by Tan ZS1, Seshadri S, Beiser A, Wilson PW, Kiel DP, Tocco M, D'Agostino RB, Wolf PA.(PubMed)

(983) Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease. by Shih PH1, Chan YC, Liao JW, Wang MF, Yen GC.(PubMed)(984) The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation by Bhuiyan MI1, Kim HB, Kim SY, Cho KO.(PubMed)
(985)  Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder by Garrett E. Alexander, MD; PhD*(PMC)
(986) The role of oxidative stress in Parkinson's disease by Dias V1, Junn E, Mouradian MM.(PubMed)
(987) Oxidative stress in Parkinson's disease by Jenner P1.(PubMed)
(988) Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models by Kim HG1, Ju MS, Shim JS, Kim MC, Lee SH, Huh Y, Kim SY, Oh MS.(PubMed)
(989) Neuroprotective effects of the cyanidin-3-O-beta-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia by Kang TH1, Hur JY, Kim HB, Ryu JH, Kim SY.(PubMed)
(990) Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage by Kang TH1, Oh HR, Jung SM, Ryu JH, Park MW, Park YK, Kim SY.(PubMed)
(991) Memory-enhancing effect of Mori Fructus via induction of nerve growth factor by Kim HG1, Oh MS.(PubMed)
(992) Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration, Carlos A Saura1, Se-Young Choi2, Vassilios Beglopoulos1, Seema Malkani1, Dawei Zhang1, 2, B.S.Shankaranarayana Rao3, Sumantra Chattarji3, Raymond J Kelleher III4,Eric R Kandel5, Karen Duff6, Alfredo Kirkwood2, Jie Shen, 1, (Science direct)
(993) Lost memories might be able to be restored, new UCLA study indicates(UCLA Newsroom)
(994) Neural stem cells improve memory in an inducible mouse model of neuronal loss. by Yamasaki TR1, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM.(PubMed)
(995) Abeta(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins by Tohda C1, Matsumoto N, Zou K, Meselhy MR, Komatsu K.(PubMed)

(996) The effects of bilateral vestibular loss on hippocampal volume, neuronal number, and cell proliferation in rats by Zheng Y1, Balabhadrapatruni S, Baek JH, Chung P, Gliddon C, Zhang M, Darlington CL, Napper R, Strupp M, Brandt T, Smith PF.(PubMed)

(907) Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease by Shih PH1, Chan YC, Liao JW, Wang MF, Yen GC.(PubMed)

(998) An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss. by Lombino F1, Biundo F, Tamayev R, Arancio O, D'Adamio L.(PubMed)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine: TCM Heart (Yang) Qi deficiency herbal Xi Yang Shen

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Treatments in Traditional Chinese Herbal Medicine

B.2. Heart (Yang) Qi deficiency
Heart Qi deficiency is a condition of the inability of the heart in transportation of nutrients to body organs, including the brain through blood circulation. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842), changes in brain tissue and behavior patterns(843)(842)..

Herbal medicine for Heart Qi deficiency
3. Xi yang shen(946),
Yin in nature, the sweet, slightly bitter, cool herb has been used in TCM to treat fatigue(947)(948), diabetes(949), cardiovascular diseases(950)(951) and atopic diseases(952), promote saliva, quench thirst(949)(950), due to yang deficiency of lungs, by enhancing the lung and spleen qi, through increasing the digestive system in absorbing vital energy and reducing the heat causes of qi stagnation through Heart, Lung, Kidney channels.

Phytochemicals
1. Resin
2. Pinene
3. α Phellandrene
4. β Phellandrene
5. α-amyrone,
6. α-amyrinone
7. α-amyrin
8. β-amyrin
8. Viridiflorol
9. Insensole
10. Insensole oxide
11. Ginseng Saponins: ginsenoside -R0, -Rb1, -Rb2, -Rb3, -Rc, -Rd, -Re, -Rf, -Rg1, -Rg2, -Rg3, -Rh1, -RA0, quinquenoside R1, gypenoside X1, F3, F11.
12. Etc.

Herbal xi yang shen used in the treatment and prevention of dementia(953) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in ameliorated amyloid pathology(953) causes of neuro cells apoptosis(954) and related cognitive deficits(955).

3.1. In Alzheimer's disease
In Alzheimer's disease cell model, induced by Abeta25-35, water extracts ofAmerican Ginseng (WEAG), exerted neuroprotective effects of SH-SY5, a human derived cell line against cells apoptosi(954). Pseudoginsenoside-F11 (PF11), a main component found in American ginseng, in Alzheimer's disease (AD) mice model, induced by scopolamine, morphine and methamphetamine, significantly mitigated learning and memory impairment in 15 days, through inhibited the expressions of β-amyloid precursor protein (APP) and Aβ1-40 in the cortex and hippocampus, restored the activities of antioxidants in decreased the production of malondialdehyde (MDA), a indicators of lipid peroxidation (953).

3.2. In Huntington’s disease and Parkinson’s disease
In neurodegeneration-like Huntington's disease and Parkinson's disease rat model, induced by 3-nitropropionic acid (3-NP). preparation of American ginseng leaves and stems significantly reduced brain degeneration through its active phytochemicals, ginsenosides, Rb1, Rb3 and Rd(958), according to Baylor College of Medicine and Austin State University(957). Ginsengsaponins, an active ingredients found in ginseng species, including American ginseng also exerted beneficial effects on aging, central nervous system (CNS) disorders, and neurodegenerative diseases through mediated protective mechanisms, including attenuated free radicals(959)(960).

3.3. In Neuroprotective effects
Pseudoginsenoside-F11 (PF11), a phytochemical of Panax quinquefolism (American ginseng) showed to exhibit its neuroprotective effect against impraired locomotor(962) on methamphetamine (MA)-induced behavioral and neurochemical toxicities in mice(964) and in Parkinson's disease (PD) of rat model, by evoked neuronal excitability and mediated the increased release of glutamate(962), motor balance, coordination, and apomorphine-induced rotation, through inhibiting free radical formation and stimulating endogenous antioxidant release(961). According to the State Key Laboratory of Chinese Medicine and Molecular Pharmacology, water extracts of American Ginseng(WEAG) also exerted its neuroprotective effect on SH-SY5Y cells apoptosis induced by Abeta25-35, in Alzheimer's Disease cellular model(963).

3.4. In Cognitive impairment
Amyloid β (Aβ) accumulation, elevated oxidative stress, and apoptosis of the neurons have shown to induce the progression of Alzheimer's disease (AD), Pseudoginsenoside-F11 (PF11) found abundantly in American ginseng, exhibited recognitive improvement effect in mouse model, through its antioxidant status in inhibition of amyloidogenesis and oxidative stress and enhancement of neuronal functions(965) as well as ameliorated cognitiveimpairment, neuroinflammation, and biochemical alterations caused by accumulation of intercellular messenger, nitric oxide (NO)(966).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(946) American Ginseng, xi yang shen(Complementary and Alternative Healing University)
(947) Anti-fatigue effects of proteins isolated from Panax quinquefolium. by Qi B1, Liu L1, Zhang H1, Zhou GX1, Wang S1, Duan XZ1, Bai XY1, Wang SM1, Zhao DQ2.(PubMed)
(948) American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study. by Kim E1, Cameron M, Lovera J, Schaben L, Bourdette D, Whitham R.(PubMed)
(949) American Ginseng Extract (Panax quinquefolius L.) Is Safe in Long-Term Use in Type 2 Diabetic Patients. by Mucalo I1, Jovanovski E2, Vuksan V3, Božikov V4, Romić Z5, Rahelić D4.(PubMed)
(950) Therapeutic potential of ginseng in the management of cardiovascular disorders by Karmazyn M1, Moey M, Gan XT.(PubMed)
(951)North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension by Stavro PM1, Woo M, Heim TF, Leiter LA, Vuksan V.(PubMed)
(952) Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo by Ebeling C1, Wu Y, Skappak C, Gordon JR, Ilarraza R, Adamko DJ.(PubMed)
(953) Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease by Wang CM1, Liu MY, Wang F, Wei MJ, Wang S, Wu CF, Yang JY.(PubMed)
(954) [Neuroprotective effects of water extracts of American Ginseng on SH-SY5Y cells apoptosis induced by Abeta25-35].[Article in Chinese] by Hu SQ1, Yu HM, Liu TS, Yang DJ, Chen XZ, He CJ.(PubMed)
(955) HT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled study by Chen EY1, Hui CL.(PubMed)
(956) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations by Rinwa P1, Kumar A.(PubMed)
(957) Ginseng compounds may fight Huntington’s disease, Parkinson’s disease(Northest Parkinson foundation)
(958) Ginseng Substances Fight Brain Disease In Rats(Bio space)
(959) Plants and phytochemicals for Huntington's disease by Sunayna Choudhary1, Puneet Kumar2, Jai Malik1(Phamarcognosy Review)
(960) Use of ginseng in medicine with emphasis on neurodegenerative disorders by Radad K1, Gille G, Liu L, Rausch WD.(PubMed)
(961) Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine by Wang JY1, Yang JY1, Wang F1, Fu SY1, Hou Y1, Jiang B1, Ma J1, Song C1, Wu CF1.(PubMed)
(962) Ginseng derivative ocotillol enhances neuronal activity through increased glutamate release: a possible mechanism underlying increased spontaneous locomotor activity of mice by Wang ZJ1, Sun L, Peng W, Ma S, Zhu C, Fu F, Heinbockel T.(PubMed)
(963) [Neuroprotective effects of water extracts of American Ginseng on SH-SY5Y cells apoptosis induced by Abeta25-35].[Article in Chinese] by Hu SQ1, Yu HM, Liu TS, Yang DJ, Chen XZ, He CJ.(PubMed)
(964) Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice. by Wu CF1, Liu YL, Song M, Liu W, Wang JH, Li X, Yang JY.(PubMed)
(965) Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease. by Wang CM1, Liu MY, Wang F, Wei MJ, Wang S, Wu CF, Yang JY.(PubMed)
(966) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations by Rinwa P1, Kumar A.(PubMed)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine: TCM herbal Ren shen (Ginseng)Treatment of Dementia Induced by Heart (Yang) Qi deficiency

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Treatments in Traditional Chinese Herbal Medicine

B.2. Heart (Yang) Qi deficiency
Heart Qi deficiency is a condition of the inability of the heart in transportation of nutrients to body organs, including the brain through blood circulation. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842), changes in brain tissue and behavior patterns(843)(842)..

Herbal medicine for Heart Qi deficiency
2. Ren shen (Ginseng)
Ren Shen is a smells aromatic, tastes sweet and slightly warm herbs, also known as Gingshen, used in TCM as improved immune system(868)(869), Anti Cancer(870)(871), Anti aging(872)(873), Anti stress(874)(875), antiErectile dysfunction(876)(877), etc. agents and to generates fluids, reduces thirst, treats symptoms of diabetes(878)(879), for xinqixu (heart qi deficient) related coronary heart disease (CHD)(880)(881), anxiety(882)(883), insomnia(884)(885), depression(886)(887), neurodegenertive disorders(888)(889)(890), bleeding in the vagina not during period(891), seizures(892)(893), chronic fatigue(894)(895), etc. as it strongly tonifies Original Qi, the Spleen and the Lungs, promotes generation of Body Fluids, calms thirst and the Mind,(896) etc. by enhancing the functions of spleen and lung channels(897).

Phytochemicals
1. Saponins
2. Panaxynol
3. Ginsenyne
4. Alpha pansinsene
5. Beta pansinsene
6. Beta farnesene
7. Bicyclogermacrene
8. Beta elemene
9. Gama elemene
10. Alpha neodovene
11. Beta neodovene
12. Alpha humulene
13. Beta humulene
14. Ccaryophyllene
15. Beta gurjunene
16. Alpha gurjunene
17. Alpha selinene
18. Beta selinene
19. Gama selinene
20. Selin-4, alpha guaiene
21. Gama cubebene
22. Beta patchoulene
23. Hepatadecanol-1
24. Etc.

Herbal ren shen used in the treatment and prevention of dementia(898) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in ameliorated amyloid pathology(899)(900) and related cognitive deficits(901). In aging related dementia, based on the history of use, and pharmacological investigation, ren shen showed a strong evidence in cognitive improvement, through cholinesterase inhibitory activity and cholinergic function(902). According to Beijing University of Chinese Medicine, combination extract of Renshen (Panax Ginseng), Yinyanghuo (Herba Epimedii Brevicornus), Yuanzhi (Radix Palygalae) and Jianghuang (Rhizoma Curcumae Longae) (GEPT) exhibited neuroprotecting mechanism for preventing and treating of AD(903).

2.1. In Alzheimer's disease
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. The disease destroys brain cells involved inflammation, mitochondrial dysfunction or oxidative stress(904), causing problems with thinking and behavior severe(904) enough to affect language communication(905), memory(906), lifelong hobbies or social life(907).
Ginseng extracts, in Alzheimer's disease (AD) patients significantly attenuated amyloid plaque deposition in short- and long-term memory impairment. through its phytochemical gintonin effect via the mediation in promotion of non-amyloidogenic processing(908). In amyloid β peptide induced AD cell model, ginsenoside Rg1, the main chemical constituent of ginseng, improved the memory impairment associated with Alzheimer's disease (AD), through suppressing the signaling transduction pathways and decreasing the inflammation factors(909)(910); increasing cell viability, reducing oxidative damage (including apoptosis), restoring mitochondrial membrane potential(911). According to the join 17-months old male APP/PS1 mice study by University of Michigan and Yunnan University of Traditional Chinese Medicine, total saponin in leaves of Panax notoginseng (LPNS) attenuated reactive oxygen species (ROS) accumulation and cell death in brain cells through activation of Nrf2 (nuclear translocation) and upregulation of downstream antioxidant systems(912).
Unfortunately, according to the review over 20 databases from the inception to January 2009 and included all randomized clinical trials (RCTs) from Korea Institute of Oriental Medicine, the use of ginseng for treatments of Alzheimer's disease is scarce and inconclusive(913).

2.2. In Parkinson's and Huntington's diseases
Parkinson's disease is a progressive disorder of the nervous system, affecting movement of muscles(917)(918), speech(919), poster, balance, auto functioning(920), etc., with disease's symptoms worsen over time. According to a multicenter study, phosphorylated forms, pS129 is associated to the severity and progression of Parkinson diseases(914). NFE2L2 gene, an important regulator of the cellular protection against oxidative stress, if defects can contribute to the pathogenesis of the disease(915)(916). In the pathogenesis of Parkinson's disease (PD), Ginsenoside Rb, effectively inhibited or reversed the aggregation process and may represent a viable therapeutic strategy against PD and related disorders, through anti-amyloidogenic and antineurotoxical effects(921). Its water extract in induced cytotoxicity of SH-SY5Y human neuroblastoma cells, also exhibited significant protective effects possibly through the suppression of ROS generation(922). According to Russian Academy of Medical Sciences, use of ginseng and other herbs, such as eleutherococcus, Rhodiola rosea, etc., in a complex therapy for Parkinson's disease, may be due to theirs normalized immune, antioxidant, and hormonal parameters(923).
In Huntington's disease, Ginsenosides, the main chemical constituents of ginseng, showed to exert its neuroprotective effect against neurons from glutamate-induced apoptosis in vitro(924).

2.3. In cognitive impairment
Klotho Gene Deficiency has been found to associate with oxidative stress related cognitive impairment(925). In aging mice model, ginseng exhibited anti oxidative stress in ameliorated lipid peroxidation, restored antioxidant capacity(926), and reduced accumulation of intercellular messenger, nitric oxide (NO)(927) activities, may be used as a potential treatment of herbal medicine for cognitive impairment(927). Ginsenoside Rb1, a major chemical constituent found in ginseng, showed to inhibit cognitive impairment caused by diabetes, through GSK3β, (a negative regulator in the hormonal control of glucose homeostasis)-mediated endoplasmic reticulum(ER) stress due tophysiological and pathological insults, in high glucose-treated hippocampal neurons(928).

2.4. In neuroprotective effects
In high glucose-induced neurotoxicity in primary cultured rat hippocampal neurons, Ginsenoside Rb1  exerted a wide variety of neuroprotective effects by inhibiting CHOP signaling pathway involved in apoptosis signal in ER stress- and CHOP-mediated apoptosis(940), oxidative stress(926), mitochondrial dysfunction(929)(941) and neuroinflammation(941). According to University Complutense of Madrid, Ginseng and its major constituents as potential neuroprotective agents against progression of Parkinson's disease(943), may be due to its effectiveness in inhibition of oxidative stress(926), neuroinflammation(941), toxins-induced apoptosis(944) and regulation of channels and receptors activity(945)(942).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(868) Immune system effects of echinacea, ginseng, and astragalus: a review by Block KI1, Mead MN.(PubMed)
(869) Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity and immune system under mental arithmetic stress. by Zheng A1, Moritani T.(PubMed)

(870) Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer by Wang CZ1, Zhang Z2, Wan JY3, Zhang CF4, Anderson S5, He X6, Yu C7, He TC8, Qi LW9, Yuan CS10.(PubMed)

(871) Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil human colorectal cancer cells. by Li XL1, Wang CZ, Mehendale SR, Sun S, Wang Q, Yuan CS.(PubMed)

(872) Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. by Zhu J1, Mu X1, Zeng J2, Xu C1, Liu J1, Zhang M1, Li C1, Chen J3, Li T3, Wang Y1.(PubMed)

(873) Hormesis-based anti-aging products: a case study of a novel cosmetic by Rattan SI1, Kryzch V, Schnebert S, Perrier E, Nizard C.(PubMed)

(874) Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study by Rai D1, Bhatia G, Sen T, Palit G.(PubMed)

(875) Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease by Kaneko H1, Nakanishi K.(PubMed)

(876) Ginsenoside Rg3 improves erectile function in streptozotocin-induced diabetic rats. by Liu T1, Peng YF, Jia C, Yang BH, Tao X, Li J, Fang X.(PubMed)
(877) Second look at the potential use of ginseng berry extract for treating erectile dysfunction by Watson DC1.(PubMed)

(878) Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin by Liu Z1, Li W, Li X, Zhang M, Chen L, Zheng YN, Sun GZ, Ruan CC.(PubMed)

(879) Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. by Liu Z1, Wang LJ, Li X, Hu JN, Chen Y, Ruan CC, Sun GZ.(PubMed)

(880) [Effect of renshen jianxin capsule for alleviating insulin resistance in patients with coronary heart disease and glucose tolerance impairment].[Article in Chinese] by Li AM1, Zhao J.(PubMed)(881) [Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality].[Article in Chinese] by Zhang Y1, Lu S, Liu YY.(PubMed)
(882) The nootropic properties of ginseng saponin Rb1 are linked to effects on anxiety by Churchill JD1, Gerson JL, Hinton KA, Mifek JL, Walter MJ, Winslow CL, Deyo RA.(PubMed)
(883) Chronic oral administration of ginseng extract results in behavioral change but has no effects in mice models of affective and anxiety disorders by Einat H1.(PubMed)
(884) Effects of Korean red ginseng (Panax Ginseng Meyer) on bisphenol A exposure and gynecologic complaints: single blind, randomized clinical trial of efficacy and safety. vt Yang M1, Lee HS, Hwang MW, Jin M.(PubMed)
(885) Hypnotic effects and binding studies for GABA(A) and 5-HT(2C) receptors of traditional medicinal plants used in Asia for insomnia by Cho SM1, Shimizu M, Lee CJ, Han DS, Jung CK, Jo JH, Kim YM.(PubMed)
(886) The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression by Xiang H1, Liu Y, Zhang B, Huang J, Li Y, Yang B, Huang Z, Xiang F, Zhang H.(PubMed)
(887) Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. by Dang H1, Chen Y, Liu X, Wang Q, Wang L, Jia W, Wang Y.(PubMed)
(888) Potential neuroprotective activity of Ginseng in Parkinson's disease: a review by González-Burgos E1, Fernandez-Moriano C, Gómez-Serranillos MP.(PubMed)
(889) Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease by Van Kampen JM1, Baranowski DB2, Shaw CA3, Kay DG4.(PubMed)
(890) Effects of Panax ginseng in Neurodegenerative Diseases. by Cho IH1.(PubMed)
(891) Ginseng and vaginal bleeding by Greenspan EM.(PubMed)
(892) Anticonvulsant activity of ginseng on seizures induced by chemical convulsants by Lian XY1, Zhang ZZ, Stringer JL.(PubMed)
(893) Anticonvulsant and neuroprotective effects of ginsenosides in rats by Lian XY1, Zhang Z, Stringer JL.(PubMed)
(894) Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study by Etemadifar M1, Sayahi F, Abtahi SH, Shemshaki H, Dorooshi GA, Goodarzi M, Akbari M, Fereidan-Esfahani M.(PubMed)
(895) Can ginseng alleviate cancer-related fatigue? by Viale PH.(PubMed)
(896) REN SHEN(TCM assistant)
(897) ren shen (ginseng)(Complementary and Alternative Healing University)
(898) Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia by Zhang G1, Liu A, Zhou Y, San X, Jin T, Jin Y.(PubMed)
(899) Ginsenoside Rh2 promotes nonamyloidgenic cleavage of amyloid precursor protein via a cholesterol-dependent pathway.by Qiu J1, Li W2, Feng SH3, Wang M3, He ZY4.(PubMed)
(900) Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease. by Rockenstein E1, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.(PubMed)
(901) Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses by Chu S1, Gu J2, Feng L3, Liu J4, Zhang M5, Jia X5, Liu M6, Yao D7.(PubMed)
(902) Comparative study of korean white, red, and black ginseng extract on cholinesterase inhibitory activity and cholinergic function. by Lee MR1, Yun BS, In OH, Sung CK.(PubMed)
(603) A combination extract of Renshen (Panax Ginseng), Yinyanghuo (Herba Epimedii Brevicornus), Yuanzhi (Radix Palygalae) and Jianghuang (Rhizoma Curcumae Longae) decreases glycogen synthase kinase 3beta expression in brain cortex of APPV7171 transgenic mice by Shi J1, Tian J, Zhang X, Zeng C, Wei M, Wang P, Wang Y.(PubMed)
(904) Cell cycle re-entry in Alzheimer's disease: a major neuropathological characteristic? by Lopes JP1, Oliveira CR, Agostinho P.(PubMed)
(905) Speech-language interventions in Alzheimer's disease. A functional communication approach. by Glickstein JK1, Neustadt GK.(PubMed)
(906) Designer receptors enhance memory in a mouse model of Down syndrome by Fortress AM1, Hamlett ED1, Vazey EM1, Aston-Jones G1, Cass WA2, Boger HA1, Granholm AC3.(PubMed)
(907) Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice by Huang H1, Wang L1, Cao M1, Marshall C1, Gao J1, Xiao N1, Hu G1, Xiao M2(PubMed)
(908) Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing by Hwang SH1, Shin EJ, Shin TJ, Lee BH, Choi SH, Kang J, Kim HJ, Kwon SH, Jang CG, Lee JH, Kim HC, Nah SY.(PubMed)
(909) Effects of ginsenoside Rg1 on the expression of toll-like receptor 3, 4 and their signalling transduction factors in the NG108-15 murine neuroglial cell line by Zhao BS1, Liu Y2, Gao XY3, Zhai HQ4, Guo JY5, Wang XY6.(PubMed)
(910) Ginsenoside Rg1 attenuates lipopolysaccharide-induced inflammatory responses via the phospholipase C-γ1 signaling pathway in murine BV-2 microglial cells by Zong Y1, Ai QL, Zhong LM, Dai JN, Yang P, He Y, Sun J, Ling EA, Lu D.(PubMed)
(911) Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation by Ma B1, Meng X1, Wang J1, Sun J1, Ren X2, Qin M1, Sun J1, Sun G3, Sun X4.(PubMed)
(912) Antioxidative effects of Panax notoginseng saponins in brain cells by Zhou N1, Tang Y2, Keep RF3, Ma X4, Xiang J5.(PubMed)
(613) Ginseng for cognitive function in Alzheimer's disease: a systematic review. by Lee MS1, Yang EJ, Kim JI, Ernst E.(PubMed)
(914) Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity. by Stewart T, Sossi V, Aasly JO, Wszolek ZK, Uitti RJ, Hasegawa K, Yokoyama T, Zabetian CP, Leverenz JB, Stoessl AJ, Wang Y, Ginghina C, Liu C, Cain KC,Auinger P, Kang UJ, Jensen PH, Shi M, Zhang J.(PubMed)
(915) Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson's disease - a multicenter study by von Otter M, Bergström P, Quattrone A, De Marco EV, Annesi G, Söderkvist P, Wettinger SB, Drozdzik M, Bialecka M, Nissbrandt H, Klein C, Nilsson M,Hammarsten O, Nilsson S, Zetterberg H.(PubMed)
(916) Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease. by von Otter M1, Landgren S, Nilsson S, Celojevic D, Bergström P, Håkansson A, Nissbrandt H, Drozdzik M, Bialecka M, Kurzawski M, Blennow K, Nilsson M,Hammarsten O, Zetterberg H.(PubMed)
(917) Voluntary control of facial musculature in Parkinson's disease. by Marneweck M1, Hammond G2.(PubMed)
(918) Discrimination and recognition of facial expressions of emotion and their links with voluntary control of facial musculature in Parkinson's disease by Marneweck M1, Palermo R1, Hammond G1.(PubMed)
(919) The intrinsic resting state voice network in Parkinson's disease by New AB1, Robin DA, Parkinson AL, Eickhoff CR, Reetz K, Hoffstaedter F, Mathys C, Sudmeyer M, Grefkes C, Larson CR, Ramig LO, Fox PT, Eickhoff SB.(PubMed)
(920) Effects of Stochastic Vestibular Galvanic Stimulation and LDOPA on Balance and Motor Symptoms in Patients With Parkinson's Disease by Samoudi G1, Jivegård M1, Mulavara AP2, Bergquist F3.(PubMed)
(921) Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils. by Ardah MT1, Paleologou KE2, Lv G3, Menon SA1, Abul Khair SB1, Lu JH4, Safieh-Garabedian B5, Al-Hayani AA6, Eliezer D3, Li M7, El-Agnaf OM8(PubMed)
(922) Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells by Hu S1, Han R, Mak S, Han Y.(PubMed)
(923) Therapeutic efficacy of the neuroprotective plant adaptogen in neurodegenerative disease (Parkinson's disease as an example). by Bocharov EV1, Ivanova-Smolenskaya IA, Poleshchuk VV, Kucheryanu VG, Il'enko VA, Bocharova OA.(PubMed)
(924) Ginsenosides protect striatal neurons in a cellular model of Huntington's disease. by Wu J1, Jeong HK, Bulin SE, Kwon SW, Park JH, Bezprozvanny I.(PubMed)
(925) Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats by Ramesh T1, Kim SW, Hwang SY, Sohn SH, Yoo SK, Kim SK.(PubMed)
(926) Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential by Shin EJ1, Chung YH1, Le HL1, Jeong JH1, Dang DK1, Nam Y1, Wie MB1, Nah SY1, Nabeshima Y1, Nabeshima T1, Kim HC1.(PubMed)
(927) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations by Rinwa P1, Kumar A.(PubMed)
(928) Ginsenoside Rb1 protects hippocampal neurons from high glucose-induced neurotoxicity by inhibiting GSK3β-mediated CHOP induction by Liu D1, Zhang H2, Gu W1, Liu Y2, Zhang M1.(PubMed)
(929) Neuroprotective effects of ginsenoside Rb1 on high glucose-induced neurotoxicity in primary cultured rat hippocampal neurons by Liu D1, Zhang H, Gu W, Liu Y, Zhang M.(PubMed)
(930) -(939)
(940) Ginsenoside Rb1 protects hippocampal neurons from high glucose-induced neurotoxicity by inhibiting GSK3β-mediated CHOP induction by Liu D1, Zhang H2, Gu W1, Liu Y2, Zhang M1.(PubMed)
(941) Modulation of nitrergic signalling pathway by American ginseng attenuates chronic unpredictable stress-induced cognitive impairment, neuroinflammation, and biochemical alterations by Rinwa P1, Kumar A.(PubMed)
(942) Potential neuroprotective activity of Ginseng in Parkinson's disease: a review by González-Burgos E1, Fernandez-Moriano C, Gómez-Serranillos MP.(PubMed)
(943) Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease by Van Kampen JM1, Baranowski DB2, Shaw CA3, Kay DG4.(PubMed)
(944) Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease by Van Kampen J1, Robertson H, Hagg T, Drobitch R.(PubMed)
(945) Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors by Nah SY1.(PubMed)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine: TCM Heart (Yang) Qi deficiency herbal Dan Shen

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Treatments in Traditional Chinese Herbal Medicine

B.2. Heart (Yang) Qi deficiency
Heart Qi deficiency is a condition of the inability of the heart in transportation of nutrients to body organs, including the brain through blood circulation. Prolong period of malnutrition of brain cells may induce abnormal function of brain's cells in information transmitting or death of neurons, causing cognitive impairment(844), including learning and memory deficits(842), changes in brain tissue and behavior patterns(843)(842)..

Herbal medicine for Heart Qi deficiency
1. Dan shen
Dan Shen is also known as Red Sage Root with taste of the bitter and slightly cold in nature, used in TCM as antithrombotic(845), antihypertonic (lowering blood pressure)(846), antimicrobial(847), anti-inflammatory(848)(849), agents and to treat coronary and cerebrovascular disease, dysmenorrhea, amenorrhea, hepatitis, hepatocirrhosis, restlessness, insomnia, irritability,(850) etc., by enhancing the functions of heart and liver channels.

Phytochemicals
1. Cryptotanshinone
2. Hydroxytanshinone,
3. Methyltanshinonate
4. Methylene tanshiquinone
5. Przewatanshinquinone A
6. Przewatanshinquinone B
7. Miltirone
8. Dihydrotanshinone I
9. Tanshinol A
10. Tanshinol B
11. Tanshinol C,
12. Nortanshinone
13. 1, 2, 15, 16-tetrahydrotanshiquinone
14. Danshensuan A, B, C
15. Protocatechuic acid,
16. Protocatechuic aldehyde
17. Etc.


1.1. Dementia
According to Mashhad University of Medical Sciences, dan shen in the pharmacological effects on the central nervous system, showed to exert its neuroprotective activity through antiparkinsonian, relaxant, analgesic and memory enhancing(850). In PC12 cells, combination application of salvianolic acid B (Sal B) and Ginkgo biloba extract EGb 761, effectively inhibited the formation of amyloid fibrils and protected PC12 cells(855) from beta-AP25-35-induced cytotoxicity and ROS accumulation(854).

1.2. Alzheimer's disease (AD)
Simple poly hydroxycinnamic acids and diterpenoid quinone, found in dan shen improved cognitive deficits in mice model, through protection of neuronal cells, prevention of amyloid fibril formation and preformed amyloid fibril disaggregation related to Alzheimer's disease(851). Salvianolic acid B (Sal B)isolated from dan shen, in animal model, not only prevented Abeta-induced cytotoxicity(857) but also improved cognitive deficits and protection of neuronal cells(852), through its effects on suppressing the production of ROS, calcium flux, and apoptosis(853), promoted amyloid precursor protein (APP) metabolism toward the non-amyloidogenic products pathway in cortical neuronal cell(856) and multifunctional machenisms(857). Compound Danshen Tablets (CDST), in rat model, exhibited spatial cognitive protection through decreased beta-APP expression in the cortex and hippocampus, detected via immunohistochemistry(859).

1.3. In learning and memory impairment
In diabetic rats model, dan shen injection improved the learning and memory decline, through upregulation of expression of MKP-1 in reduced inflammation(861) and hyperglycemia(860). HX106N, a Chimese herbal formula, containing dan shen, in Aβ25-35 peptide mice, enhanced on memory impairment and oxidative stress through increased levels of heme oxygenase-1 (HO-1)(862). In a joint study of renowned institutions, in mouse model, myelophil, a combination of extracts taken from Astragali Radix and Salviae Miltiorrhizae Radix, significantly exhibited its anti-amnesic properties in memory impairment, through the modulation of cholinergic activity(863). Tanshinones, a group of diterpenoids found in dan shen, also improved learning and memory impairments, through its inhibitory effect on acetylcholinesterase(864)

1.4. In neuroprotective effects
Tanshinone IIA (Tan IIA), one of the major active constituents of dan shen exerted its neuroprotective effects, by inhibiting transcription and translation of genes involved AD development(858). In neurotoxicity of β-amyloid protein (Aβ), contributed Alzheimer's disease (AD), dan shen extract suppressed the increased intracellular reactive oxygen species levels, through deduction of decreased the protein expression involved in the development of neurodegenerative disease, including ADs(865). According to Eur J Pharmacol and University of Sydney, salvianolic acid B (SalB) found in dan shen, in mouse model, exhibited neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease, through its anti-inflammatory, anti-oxidative effects(866) and ameliorated cholinergic dysfunction- or Aβ(25-35)-induced memory impairment(867), respectively.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(842) Folate deficiency in rat pups during weaning causes learning and memory deficits. by Berrocal-Zaragoza MI1, Sequeira JM1, Murphy MM2, Fernandez-Ballart JD2, Abdel Baki SG3, Bergold PJ3, Quadros EV1.(PubMed)
(843) Changes in brain tissue and behavior patterns induced by single short-term fasting in mice. by Hisatomi Y1, Asakura K, Kugino K, Kurokawa M, Asakura T, Nakata K.(PubMed)
(844) Combined low calcium and lack magnesium is a risk factor for motor deficit in mice. by Taniguchi R1, Nakagawasai O, Tan-no K, Yamadera F, Nemoto W, Sato S, Yaoita F, Tadano T.(PubMed)
(845) Antiplatelet and antithrombotic activities of salvianolic acid A by Fan HY1, Fu FH, Yang MY, Xu H, Zhang AH, Liu K.(PubMed)
(846) The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation. byb Ng CF1, Koon CM, Cheung DW, Lam MY, Leung PC, Lau CB, Fung KP.(PubMed)
(847) [Roles of reactive oxygen species in Streptomyces pactum Act12-induced tanshinone production in Salvia miltiorrhiza hairy roots].[Article in Chinese] by Yan Y, Zhao X, Zhang SC, Liu Y, Liang ZS.(PubMed)
(848) [Clinical observation of treating 62 patients with severe aplastic anemia failing in immunosuppressive therapy by integrative medicine].[Article in Chinese] by Su EY1, Fang YH, Chen HS.(PubMed)
(849) Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis. by Chen Z1, Xu H2.(PubMed)
(850) The pharmacological effects of Salvia species on the central nervous system by Imanshahidi M1, Hosseinzadeh H.(PubMed)
(851) Danshen diversity defeating dementia by Hügel HM1, Jackson N2.(PubMed)
(852) Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. by Durairajan SS1, Yuan Q, Xie L, Chan WS, Kum WF, Koo I, Liu C, Song Y, Huang JD, Klein WL, Li M.(PubMed)
(853) [Comparison of the inhibitory activities of salvianolic acid B and Ginkgo biloba extract EGb 761 on neurotoxicity of beta-amyloid peptide].[Article in Chinese] by Liu CS1, Hu JF, Chen NH, Zhang JT.(PubMed)
(854) [Comparison of the inhibitory activities of salvianolic acid B and Ginkgo biloba extract EGb 761 on neurotoxicity of beta-amyloid peptide].[Article in Chinese] by Liu CS1, Hu JF, Chen NH, Zhang JT.(PubMed)
(855) Tanshinone IIA protects PC12 cells from β-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. by Dong H1, Mao S, Wei J, Liu B, Zhang Z, Zhang Q, Yan M.(PubMed)
(856) Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro by Mei Z1, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.(PubMed)
(857) Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer's disease. by Cao YY1, Wang L, Ge H, Lu XL, Pei Z, Gu Q, Xu J.(PubMed)
(858) Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP‑2 and NF‑κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. by Jiang P1, Li C1, Xiang Z2, Jiao B2.(PubMed)
(859) Effects of compound danshen tablets on spatial cognition and expression of brain beta-amyloid precursor protein in a rat model of Alzheimer's disease by Qin RA1, Yao XX, Huang ZY.(PubMed)
(860) Protective effects of Salvia miltiorrhiza injection against learning and memory impairments in streptozotocin-induced diabetic rats by Cai H1, Lian L2, Wang Y2, Yu Y2, Liu W2.(PubMed)
(861) Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators by Doddareddy MR1, Rawling T, Ammit AJ.(PubMed)
(862) Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25-35-induced memory impairment and oxidative stress in mice. by Lee DS1, Choi J, Kim SH, Kim S.(PubMed)
(863) Ethanol extract of Astragali Radix and Salviae Miltiorrhizae Radix, Myelophil, exerts anti-amnesic effect in a mouse model of scopolamine-induced memory deficits. by Lee JS1, Kim HG1, Han JM1, Kim DW2, Yi MH2, Son SW3, Kim YA1, Lee JS4, Choi MK1, Son CG5.(PubMed)
(864) Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice by Kim DH1, Jeon SJ, Jung JW, Lee S, Yoon BH, Shin BY, Son KH, Cheong JH, Kim YS, Kang SS, Ko KH, Ryu JH.(PubMed)
(865) Neuroprotection against Aβ25-35-induced apoptosis by Salvia miltiorrhiza extract in SH-SY5Y cells by Yu H1, Yao L2, Zhou H3, Qu S1, Zeng X1, Zhou D1, Zhou Y1, Li X1, Liu Z4.(PubMed)
(866) Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer's disease. by Lee YW1, Kim DH, Jeon SJ, Park SJ, Kim JM, Jung JM, Lee HE, Bae SG, Oh HK, Son KH, Ryu JH.(PubMed)
(867) Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B by Kim DH1, Park SJ, Kim JM, Jeon SJ, Kim DH, Cho YW, Son KH, Lee HJ, Moon JH, Cheong JH, Ko KH, Ryu JH.(PubMed)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine: TCM Treatment of Dementia Induced by Kidney Qi Deficiency

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Treatment in Traditional Chinese Herbal Medicine

B. In traditional Chinese Medicine Perspective(*)
Based on Chinese ancient medical records, causes of dementia are the results of (*)
B.1. Deficiency of Qi, mainly due to
B.1.1. Kidney Qi deficiency
Kidney Qi deficiency is a condition of the inability of kidney in expelling extra fluid in the body through urinary secretion via bladder. If the fluid accumulation(a) or hydration(b) occurs in the brain(a) for a prolong period of time, can induce abnormal function of neurons in information transmitting or gradual death of brain's neurons(c), leading cognitive impairment, including dementia. In elders, kidney Qi deficiency may also be related to gradual depletion of kidney essences(Jing) due to aging, according to traditional Chinese medicine.


Chinese herbs used to treat kidney Qi deficiency include
1. Lu rong(810)
Lu rong is also known as deer antler, deer antler velvet, used in traditional Chinese medicine to reduce the blockage of the meridian liver and kidney for treatment of rheumatoid arthritis(811), osteoarthritis(812), sexual function(813)(814), and sporting performance enhancement(810)(815) by enhancing the yang energy(815). Since qi deficiency is also related to blood deficiency(816), improving the body yang by strengthening the liver's function in blood formation(816) and kidney's function in fluid distribution(817), reduce the yang deficiency in the body. In neuroprotective effect, deer antler extract prevented glutamate-induced oxidative stress of reactive oxygen species and lipid peroxidation causes of neurodegenerative disorders(832).

2. Du Zhong
Du Zhong, also known ecommia bark, is one the most used herb to enhance the function of meridian kidney-liver by promoting the qi and blood formation. The liver is a organ in charge of blood storing and blood formation(818) and kidney is in charge of fluid regulation(817).
Administration of the du zhong promotes kidney yang through action of harmony by increasing blood flow(819) and reducing fluid accumulated(820) in the body (821). In learning and memory deficits mice caused by oxidative stress, du zhong significantly improved the impairment of short-term or working memory and reversed learning and memory deficits(833), through inhibited acetylcholinesterase (AChE) activity in a dose-dependent manner (834) and oxidative stress causes of neuronal cell death(835)

3. Ba Ji Tian
Ba ji tian, is also known as Chinese morinda root with sweet and warm in nature, used in TCM to strengthen the liver(823), kidney qi(822) and blood yang(824) for enhancing the liver in blood formation and kidney in urinary secretion, According to Academy of Military Medical Sciences, ba ji tian showed a strong anti antidepressant activities through its phytochemicals succinic acid, nystose, 1F-fructofuranosylnystose, inulin-type hexasaccharide and heptasaccharide(836)(837).

4. Rou Chong Rong
Rou Chong Rong is also known as Herba Cistanche used in traditional Chinese medicine for reducing the blockage of kidney-large intestine meridian(825), by increasing the kidney function in fluid regulation through improved blood circulation(826), assisted urinary secretion and digestive system in moving waste. In mouse model with learning and memory deficit, rou chong rong extract increased neuronal cell differentiation, neurite length, and synapse formation in hippocampus, through nerve growth factor (NGF) biological activities, such as preventing neuronal death(838), memory loss, and increaseing long-term potentiation and learning task(839).

5. Bu Gu Zhi
Bu gu zhi is also known as psoralea fruit used in traditional Chinese medicine in treating blockage of meridian kidney-Spleen(827) by tonifying the yang(828), increasing the kidney function(829) and assisting the functions of lung qi(830) and spleen in qi distribution(831). In stem neoronal study, phytochemicals psoralen, oleanolic acid, and stilbene glucoside found in psoralea fruit exerted its anti cognitive protective effect through promoting self-renewal of neural stem cells NSCs and neuron-like differentiation(840). In rat with Huntington's disease (HD) using 3-NP induced mitochondrial dysfunction in cultured (PC12) cells, psoralea corylifolia Linn seed extracts, showed a significant protective effect against 3-nitropropionic acid (3-NP) induced cytotoxicity(841).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References

(810) Health benefits of deer and elk velvet antler supplements: a systematic review of randomised controlled studies by Gilbey A1, Perezgonzalez JD.(PubMed)
(811) Elk velvet antler in rheumatoid arthritis: phase II trial. by Allen M1, Oberle K, Grace M, Russell A.(PubMed)
(812) The effects of velvet antler polypeptides on the phenotype and related biological indicators of osteoarthritic rabbit chondrocytes. by Zhang Z1, Liu X, Duan L, Li X, Zhang Y, Zhou Q.(PubMed)
(813) Deer antlers as a model of Mammalian regeneration. by Price J1, Faucheux C, Allen S.(PubMed)
(814) Growth and reproductive performance of sambar deer in Sabal Forest Reserve of Sarawak, Malaysia. by Dahlan I1, Dawend J.(PubMed)
(815) Deer Antler Velvet (Lu Rong)(Chinese herb healing)
(816) Mechanisms of Qi-blood circulation and Qi deficiency syndrome in view of blood and interstitial fluid circulation. by Yao W1, Yang H, Ding G.(PubMed)
(817) Kidneys(Traditional Chinese medicine basics)
(818) Liver(Inner body)
(819) [Research about formulas for activating blood and resolving stasis Xuesaitong capsule regulate CD117+ hemopoietic stem cell to produce new blood].[Article in Chinese] by Zhang BX, Zhang JS, Du MM, Zhang YY, Zhu HF.(PubMed)
(820) Eucommia Bark(Dallas Acupuncture Works)
(821) DU ZHONG(Four flowers)
(822) Ba Ji Tian(TCMwiki)
(823) Ba ji tian(Complementary and Alternative Healing University),
(824) Rou Cong Rong(TCMcure)
(825) Rou Cong Rong(Complementary and Alternative Healing University)
(826) Overcome Infertility - How to Treat Cold Uterus in The Yang Phrase Of Menstrual Cycle by Kyle J. Norton
(827) Bu Gu Zhi(TCMWiki)
(828) Bu Gu Zhi(Qiherbal)
(829) Bu Gu Zhi(Plantcures)
(830) Bu Gu Zhi Psoralea Fruit - Chinese Herbal Medicine
(831) BU GU ZHI(Fourflowers)
(832) Neuroprotective action of deer bone extract against glutamate or Aβ₁₋₄₂-induced oxidative stress in mouse hippocampal cells. by Kim CR1, Jeon HL, Shin SK, Kim HJ, Ahn CW, Jung SU, Park SH, Kim MR.(PubMed)
(833) Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice. by Kwon SH1, Ma SX1, Joo HJ1, Lee SY1, Jang CG1.(PubMed)
(834) Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice by Kwon SH1, Lee HK, Kim JA, Hong SI, Kim SY, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG.(PubMed)
(835) Eucommia ulmoides Oliv. bark. attenuates 6-hydroxydopamine-induced neuronal cell death through inhibition of oxidative stress in SH-SY5Y cells. by Kwon SH1, Ma SX1, Hong SI1, Kim SY2, Lee SY1, Jang CG3.(PubMed)
(836) [Antidepressant active constituents in the roots of Morinda officinalis How].[Article in Chinese] by Cui C1, Yang M, Yao Z, Cao B, Luo Z, Xu Y, Chen Y.(PubMed)
(837) The effect of Morinda officinalis How, a Chinese traditional medicinal plant, on the DRL 72-s schedule in rats and the forced swimming test in mice by Zhong-Qi Zhang, , Li Yuan, Ming Yang, Zhi-Pu Luo, Yi-Min Zhao(Sciencedirect)
(838) Cistanches Herba enhances learning and memory by inducing nerve growth factor. byChoi JG1, Moon M, Jeong HU, Kim MC, Kim SY, Oh MS.(PubMed)
(839) The multi-herbal medicine Gongjin-dan enhances memory and learning tasks via NGF regulation. by Moon E1, Her Y, Lee JB, Park JH, Lee EH, Kim SH, Oh MS, Jang CG, Kim SY.(PubMed)
(840) [Effective Components of three kinds of shen-supplementing Chinese medicine on self-renewal and neuron-like differentiation of NSCs in AD mouse embryos: an experimental research].[Article in Chinese] by Zhang YL, Zhang LL, Song WS, Han WW, Huang JH, Zhou Z.(PubMed)
(841) Neuroprotective effects of Psoralea corylifolia Linn seed extracts on mitochondrial dysfunction induced by 3-nitropropionic acid.by Im AR, Chae SW, Zhang GJ, Lee MY1.(PubMed)