Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday, 4 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Gallic acid and Cinnamic acid

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
C. Phytochemicals Against Dementia
G.6. Gallic acid
Gallic acid is a phytochemical in the class of Phenolic acids, found abundantly in tea, mango, strawberries, rhubarb, soy, etc.
1. Cytotoxic and antioxidative activities(367)
Gallic acid showed to exert its antioxidant in inhibition of free radical effects against 2,2-diphenyl-1-picrylhydrazyl(DPPH), a stable free-radical molecules(354), nitric oxide (NO) and superoxide (SO) radicals(353)(355), probably through its chelation of ferrous ions(355). In bacterias, the phytochemical extract containing gallic acid also exhibited a strong anti microbial effect(357)(358) from species of Hypogymnia physodes and Cladonia foliacea(356); In cancers, gallic acid induced tumor cytotoxic effects(357), through antiproliferative induced apoptosis(359), cell cycle arrest(362) and suppression of cancer cell-mediated angiogenesis(360), such as mitochondrial dysfunction(361). Neurologically. gallic acid reduced oxidative stress and mitochondrial dysfunction causes of the pathology of secondary neuronal damage in induction of dementia(363); its anti-aggregating effect also inhibited α-synuclein (α-syn) causes of in many neurological disorders including Parkinson's disease (PD), dementia with Lewy bodies(364).

2. Anti inflammatory activity(367)
Gallic acid showed to inhibit inflammation(366) through its scavenging of superoxide anions, inhibition of myeloperoxidase release and activity via mediation of inflammatory process(365).

C.7. Cinnamic acid
Cinnamic acid is a phytochemical in the class of Hydroxycinnamic acids, found abundantly in cinnamon, aloe. etc.
1. Antioxidant effects
Mitochondrial oxidative damage is associated with a number of clinical disorders. Mitochondria-targeted antioxidant (TPP-OH), including cinnamic acid exhibited its antioxidant activity in protection of cells against H(2)O(2) and linoleic acid hydroperoxide-induced oxidative stress(371)(368). The phytochemical also showed a promising free radical scavenging(369) and anti-inflammatory(375), antidiabetic(374), antimicrobial(371), anticancer(377)(378), lipid-lowering(379)(380), and cardiovascular-disease-lowering activity(369)(370)(380). Neurologically, cinnamon has also been reported to have activities against neurological disorders(372)(375)(376), such as Parkinson's and Alzheimer's diseases(373)(370)

2, Anti-platelet aggregation
Novel ligustrazinyloxy-cinnamic acid derivatives showed to inhibit platelet aggregation in vitro(380), and its p-amidinophenyl esters also exerted antithrombotic effects as irreversible inhibitors of the vitamin-K dependent enzymes(382) which plays an important role in the pathogenesis of chronic obstructive pulmonary disease(381).

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References
(367) http://www.ncbi.nlm.nih.gov/pubmed/22115493
(368) http://www.ncbi.nlm.nih.gov/pubmed/22292941
(369) http://www.ncbi.nlm.nih.gov/pubmed/22512578
(370) http://www.ncbi.nlm.nih.gov/pubmed/24817901
(371) http://www.ncbi.nlm.nih.gov/pubmed/24631135
(372) http://www.ncbi.nlm.nih.gov/pubmed/24239092
(373) http://www.ncbi.nlm.nih.gov/pubmed/24349472
(374) http://www.ncbi.nlm.nih.gov/pubmed/21550075
(375) http://www.ncbi.nlm.nih.gov/pubmed/23497886
(376) http://www.ncbi.nlm.nih.gov/pubmed/23475543
(377) http://www.ncbi.nlm.nih.gov/pubmed/23977653
(378) http://www.ncbi.nlm.nih.gov/pubmed/20653974
(379) http://www.ncbi.nlm.nih.gov/pubmed/22186322
(380) http://www.ncbi.nlm.nih.gov/pubmed/21993151
(381) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629972/

The Best and Healthy homemade: Basil mayonnaise

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca

Basil mayonnaise is a delicious alternative to regular mayonnaise and a lovely complement to chicken, shrimp and vegetable sandwiches
1.4 cup mayonnaise
1tbsp. finely chopped fresh basil
1 squeeze fresh lemon juice
In small bowl, combine ingredients thoroughly
Yield 1/4 cup

17. Asian chili mayonnaise
1.4 cup mayonnaise
1/2 tsp. Sriracha Asian chili hot sauce or more if preferred
1/2 tsp. soy sauce
4 drops of sesame oil

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Saturday, 3 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Tangeritin and Curcumin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
C. Phytochemicals Against Dementia
C.4. Tangeritin
Tangeritin, one of the flavones, is found in tangerine and many citrus peels.
1. Neuroprotective effects
Natural antioxidant tangeretin, may be used as neuroprotective agent, for its significant effects on protection of striato-nigral integrity and functionality in patients with Parkinson's disease(327), probably through its anti-neuroinflammatory activity(328) via mitochondrial depolarization(329) in attenuated reactive oxygen species generation.

2. Antioxidants
Mature and immature calamondin (Citrus mitis Blanco) peel, containing tangeretin showed to exhibit its antioxidant(331) in enhancing the highest oxygen radical absorbance capacity (ORAC) reducing power, and superoxide scavenging effect(330), as well as ameliorating oxidative stress causes of DNA damage(332), mammary carcinoma(333)(334) and diabetes(335).

C.5. Curcumin
Turmeric, principal curcuminoid of the popular Indian spice, is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia, used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders(336). Curcumin, a phytochemical found abundant in the plant, in acidic solutions (pH <7.4) turns yellow, whereas in basic (pH > 8.6) solutions turns bright red.
1. Alzheimer's disease and Anti-inflammatory agent
a. Alzheimer's disease
Increased antioxidant and anti-inflammatory consumption such as curcumin may reduce risk of Alzheimer's disease (AD) caused by amyloid beta (Abeta) accumulation(338) through reversal of Abeta-induced cognitive deficits and neuropathology(339). The phytochemical is also found to disaggregate Abeta in preventing fibril and oligomer formation(338). According to Yamagata University, its synthesized curcumin analogues used pharmateutically in treatment of amyloid β aggregation also experience notable result(337). In vitro and animal models, curcumin was effective, in lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid depositio in prevented onset of Alzheimer's disease(340).

b. Anti-inflammatory agent
Curcumin, an anti-inflammatory agent(341), in the pathogenesis of psoriasis and neurodegenerative diseases,, decreased the expression of pro-inflammatory cells signalling in response to inflammation(342)(343), in patients of ear infection and Parkinson's disease and Alzheimer's disease(344)(345), respectively.

2. Antioxidants
Curcumin also consisting anti-proliferative, anti-inflammatory and immunosuppressive activitie(346), in arthritis, strongly inhibited collagenase and stromely in expression at micromolar concentrations(346); in diabetes, scavenged free radicals and reduced LDL oxidation and cellular oxidative stress(347); in cancers, reduced accumulation of ROS causes of abnormal cells(348), through apoptosis(349); in neurodegenerative diseases, exerted autophagy-lysosomal activities, through removing damaged or dysfunctional proteins and cells with specific function(350) and regulating reactive oxygen species (ROS)(351)(352).
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Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(327) http://www.ncbi.nlm.nih.gov/pubmed/11726811
(328) http://www.ncbi.nlm.nih.gov/pubmed/24462494
(329) http://www.ncbi.nlm.nih.gov/pubmed/22678994
(330) http://www.ncbi.nlm.nih.gov/pubmed/23194504
(331) http://www.ncbi.nlm.nih.gov/pubmed/20420369
(332) http://www.ncbi.nlm.nih.gov/pubmed/24995432
(333) http://www.ncbi.nlm.nih.gov/pubmed/24299963
(334) http://www.ncbi.nlm.nih.gov/pubmed/25151216
(335) http://www.ncbi.nlm.nih.gov/pubmed/24629597
(336) http://www.sciencedirect.com/science/article/pii/S0308814608009084
(337) http://www.ncbi.nlm.nih.gov/pubmed/2546714
(338) http://www.ncbi.nlm.nih.gov/pubmed/15590663
(339) http://www.ncbi.nlm.nih.gov/pubmed/11755008
(340) http://www.ncbi.nlm.nih.gov/pubmed/25467149
(341) http://www.ncbi.nlm.nih.gov/pubmed/3546166
(342) http://www.ncbi.nlm.nih.gov/pubmed/23825622
(343) http://www.ncbi.nlm.nih.gov/pubmed/25514226
(344) http://www.ncbi.nlm.nih.gov/pubmed/20930270
(345) http://www.ncbi.nlm.nih.gov/pubmed/22426019
(346) http://www.ncbi.nlm.nih.gov/pubmed/16807698
(347) http://www.ncbi.nlm.nih.gov/pubmed/25477660
(348) http://www.ncbi.nlm.nih.gov/pubmed/15700780
(349) http://www.ncbi.nlm.nih.gov/pubmed/25349781
(350) http://www.ncbi.nlm.nih.gov/pubmed/24494187
(351) http://www.ncbi.nlm.nih.gov/pubmed/24335167
(352) http://www.ncbi.nlm.nih.gov/pubmed/24008671

The Best and Healthy Lunch: Flank stead sandwich

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca

Ciabatta is a crusty bread that goes well with roasted beef and steak sandwich. if you cannot find the individual buns, buy a loaf and cut into slices. Foccacia also works well with beef sandwich.
4 thin slices Barbecued Asian Flank steak
2 tsp. chili mayonnaise
1 ciabatta bun cut in half horizontally
1 large handful arugula
6 slices cucumber
2 thin slices sweet pepper
1 -2 slices mozzarella cheese(optional)

The day before, prepare Barbecued Asian flank steak for dinner and refrigerate leftover. Prepare chili mayonnaise and organize ingredients. Refrigerate overnight.
In the morning, spread one half of bun with chili mayonnaise. Top with arugula and then slices of barbecued Asian Flank streak, cucumber, red pepper, cheese (if using) and remaining half of the bun. Cut sandwich in half and pack in reusable container.
Yield serves 1

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Friday, 2 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Gingerole and Naringenin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
C. Phytochemicals Against Dementia
C.2. Gingerole
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger. and in variety of other plants. The herb has been used for treatment of nausea and vomiting of pregnancy, motion sickness, rheumatoid arthritis, relieve migraine, etc. in folk medicine.
1. Antioxidant and anti-inflammatory effects
Chemical constituents of Zingiber officinale Rosc.(Zingiberaceae) showed to attenuate oxidative stress, through its scavenging, and inhibiting superoxide and hydroxyl radicals of ROS species(310), via nephroprotective effect on mediation of oxidative stress, inflammatory processes, and renal dysfunction(311).

2. Dementia
Ginger(70% aqueous/methanolic extract of dried ginger (Zo.Cr)) beside induced spasmolytic activity in stomach fundus in treating dementia in South Asia, it also inhibited butyrylcholinesterase (BuChE) in improvement of cognitive performance patients with dementia(4) and Vascular dementia (VaD)(315), probably through cholinergic anti-inflammatory pathway in reduced production of amyloid-β(316).

C.3. Naringenin
Naringenin, a flavanone, belonging to the red, blue, purple pigments of Flavonoids (polyphenols) found predominantly in citrus fruits is considered as one of powerful antioxidant with many health benefits.
1. Antioxidant, free radical scavenging
Naringin showed to reduce DNA damage through its antioxidant capacities in scavenging free radicals hydroxyl and superoxide(317). Cognitively, naringenin ameliorates Alzheimer's disease (AD)-type neurodegeneration(318) by improving learning and memory ability of patient with early onset of the diseases(319). Pharmacologically, the phytochemical was found to be a potential anticancer, antimutagenic, anti-inflammatory, antiproliferative and antiatherogenic agent(320).

2. Anti-inflammatory effects(320)
Neuroinflammation is considered as a constant event in Alzheimer's disease (AD), with no evidences for its direct involvement in development(322). In diabetic mice model, naringenin exhibited its anti inflammatory activity in lowering blood glucose and urea nitrogen, increasing insulin level and creatinine clearance(321), probably through inhibition of iNOS protein and anti inflammatory pathways(323).

3. Immunity
Adaptive and innate immune deficit were shown to associate with cognitive dysfunction in patients with AD and mild cognitive impairment (MCI)(325). Naringenin, stimulated the production T cells in regulating the immune system, in suppression of allergies and autoimmune diseases(324) which are considered as Alzheimer's and Parkinson's disease variants(326).

The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375
(314) http://www.ncbi.nlm.nih.gov/pubmed/18812031
(315) http://www.ncbi.nlm.nih.gov/pubmed/24727881
(316) http://www.ncbi.nlm.nih.gov/pubmed/24359497
(317) http://www.ncbi.nlm.nih.gov/pubmed/20394007
(318) http://www.ncbi.nlm.nih.gov/pubmed/22898296
(318) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(319) http://www.ncbi.nlm.nih.gov/pubmed/24337945
(320) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(321) http://www.ncbi.nlm.nih.gov/pubmed/22117528
(322) http://www.ncbi.nlm.nih.gov/pubmed/23841061

(323) http://www.ncbi.nlm.nih.gov/pubmed/18274639
(324) http://www.ncbi.nlm.nih.gov/pubmed/22324845
(325) http://www.ncbi.nlm.nih.gov/pubmed/25201785
(326) http://www.ncbi.nlm.nih.gov/pubmed/24786080

The Best, and Healthy recipe: Home made pesto

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca

Pesto is useful to have on hand. It can be tossed with pasta to make Kid's Pesto salad or used in variety of different sandwiches. If your school is nut-free, simply omit the pine nuts---the pesto is delicious this way too! Extra pesto can be frozen in ice cube trays
1/2 cup packed fresh basil leaves
1 cup grated Parmesan cheese
1/2 cup pine nut(optional)
2 garlic cloves
2-4 tbsp. extra virgin olive oil
In bowl of food processor, process basil, Parmesan, pine nuts(if using) and garlic until finely minced. With processor running, slowly pour olive oil through feeding tube and process until smooth consistently is reached.
Yield approximately 2 cups.Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca