Saturday, 3 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Tangeritin and Curcumin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
C.4.  Tangeritin
Tangeritin, one of the flavones, is found in tangerine and many citrus peels.
1. Neuroprotective effects
Natural antioxidant tangeretin, may be used as neuroprotective agent, for its significant effects on protection of striato-nigral integrity and functionality in patients with Parkinson's disease(327), probably through its anti-neuroinflammatory activity(328) via mitochondrial depolarization(329) in attenuated reactive oxygen species generation.

2. Antioxidants

Mature and immature calamondin (Citrus mitis Blanco) peel, containing tangeretin showed to exhibit its antioxidant(331) in enhancing the highest oxygen radical absorbance capacity (ORAC) reducing power, and superoxide scavenging effect(330), as well as ameliorating oxidative stress causes of DNA damage(332), mammary carcinoma(333)(334) and diabetes(335).


C.5. Curcumin

Turmeric, principal curcuminoid of the popular Indian spice, is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia, used in traditional herbal medicine as an anti-inflammatory agent and to treat gastrointestinal symptoms associated with irritable bowel syndrome and other digestive disorders(336). Curcumin, a phytochemical found abundant in the plant, in acidic solutions (pH <7.4) turns yellow, whereas in basic (pH > 8.6) solutions turns bright red.
1. Alzheimer's disease and Anti-inflammatory agent
a. Alzheimer's disease
Increased antioxidant and anti-inflammatory consumption such as curcumin may reduce risk of Alzheimer's disease (AD) caused by amyloid beta (Abeta) accumulation(338) through reversal of Abeta-induced cognitive deficits and neuropathology(339). The phytochemical is also found to disaggregate Abeta in preventing fibril and oligomer formation(338). According to Yamagata University, its synthesized curcumin analogues used pharmateutically in treatment of amyloid β aggregation also experience notable result(337). In vitro and animal models, curcumin was effective, in lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid depositio in prevented onset of Alzheimer's disease(340).

b. Anti-inflammatory agent

  Curcumin, an anti-inflammatory agent(341), in the pathogenesis of psoriasis and neurodegenerative diseases,, decreased the expression of pro-inflammatory cells signalling in response to inflammation(342)(343), in patients of ear infection and Parkinson's disease and Alzheimer's disease(344)(345), respectively.

2. Antioxidants

Curcumin also consisting anti-proliferative, anti-inflammatory and immunosuppressive activitie(346), in arthritis, strongly inhibited collagenase and stromely in expression at micromolar concentrations(346); in diabetes, scavenged free radicals and reduced LDL oxidation and cellular oxidative stress(347); in cancers, reduced accumulation of ROS causes of abnormal cells(348), through apoptosis(349); in neurodegenerative diseases, exerted autophagy-lysosomal activities, through removing damaged or dysfunctional proteins and cells with specific function(350) and regulating reactive oxygen species (ROS)(351)(352).
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References
(327) http://www.ncbi.nlm.nih.gov/pubmed/11726811
(328) http://www.ncbi.nlm.nih.gov/pubmed/24462494
(329) http://www.ncbi.nlm.nih.gov/pubmed/22678994
(330) http://www.ncbi.nlm.nih.gov/pubmed/23194504
(331) http://www.ncbi.nlm.nih.gov/pubmed/20420369
(332) http://www.ncbi.nlm.nih.gov/pubmed/24995432
(333) http://www.ncbi.nlm.nih.gov/pubmed/24299963
(334) http://www.ncbi.nlm.nih.gov/pubmed/25151216
(335) http://www.ncbi.nlm.nih.gov/pubmed/24629597
(336) http://www.sciencedirect.com/science/article/pii/S0308814608009084
(337) http://www.ncbi.nlm.nih.gov/pubmed/2546714
(338) http://www.ncbi.nlm.nih.gov/pubmed/15590663
(339) http://www.ncbi.nlm.nih.gov/pubmed/11755008
(340) http://www.ncbi.nlm.nih.gov/pubmed/25467149
(341) http://www.ncbi.nlm.nih.gov/pubmed/3546166
(342) http://www.ncbi.nlm.nih.gov/pubmed/23825622
(343) http://www.ncbi.nlm.nih.gov/pubmed/25514226
(344) http://www.ncbi.nlm.nih.gov/pubmed/20930270
(345) http://www.ncbi.nlm.nih.gov/pubmed/22426019
(346) http://www.ncbi.nlm.nih.gov/pubmed/16807698
(347) http://www.ncbi.nlm.nih.gov/pubmed/25477660
(348) http://www.ncbi.nlm.nih.gov/pubmed/15700780
(349) http://www.ncbi.nlm.nih.gov/pubmed/25349781
(350) http://www.ncbi.nlm.nih.gov/pubmed/24494187
(351) http://www.ncbi.nlm.nih.gov/pubmed/24335167
(352) http://www.ncbi.nlm.nih.gov/pubmed/24008671

The Best and Healthy Lunch: Flank stead sandwich

Posted By Kyle J. Norton 
  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca 

Ciabatta is a crusty bread that goes well with roasted beef and steak sandwich. if you cannot find the individual buns, buy a loaf and cut into slices. Foccacia also works well with beef sandwich.
4 thin slices Barbecued Asian Flank steak
2 tsp. chili mayonnaise
1 ciabatta bun cut in half horizontally
1 large handful arugula
6 slices cucumber
2 thin slices sweet pepper
1 -2 slices mozzarella cheese(optional)

The day before, prepare Barbecued Asian flank steak for dinner and refrigerate leftover. Prepare chili mayonnaise and organize ingredients. Refrigerate overnight.
In the morning, spread one half of bun with chili mayonnaise. Top with arugula and then slices of barbecued Asian Flank streak, cucumber, red pepper, cheese (if using) and remaining half of the bun. Cut sandwich in half and pack in reusable container.
Yield serves 1 

Chinese Secrets To Fatty Liver And Obesity Reversal
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Friday, 2 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Gingerole and Naringenin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
C.2. Gingerole
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger. and in variety of other plants. The herb has been used for treatment of nausea and vomiting of pregnancy, motion sickness, rheumatoid arthritis, relieve migraine, etc. in folk medicine.
1. Antioxidant and anti-inflammatory effects
 Chemical constituents of Zingiber officinale Rosc.(Zingiberaceae) showed to attenuate oxidative stress, through its scavenging, and inhibiting superoxide and hydroxyl radicals of ROS species(310), via nephroprotective effect on mediation of oxidative stress, inflammatory processes, and renal dysfunction(311).

2. Dementia

 Ginger(70% aqueous/methanolic extract of dried ginger (Zo.Cr)) beside induced spasmolytic activity in stomach fundus in treating dementia in South Asia, it also inhibited butyrylcholinesterase (BuChE) in improvement of cognitive performance patients with dementia(4) and Vascular dementia (VaD)(315), probably through cholinergic anti-inflammatory pathway in reduced production of amyloid-β(316).

C.3.  Naringenin
Naringenin, a flavanone, belonging to the red, blue, purple pigments of Flavonoids (polyphenols) found predominantly in citrus fruits is considered as one of powerful antioxidant with many health benefits.
1. Antioxidant, free radical scavenging 
 Naringin showed to reduce DNA damage through its antioxidant capacities in scavenging free radicals hydroxyl and superoxide(317). Cognitively, naringenin ameliorates Alzheimer's disease (AD)-type neurodegeneration(318) by improving learning and memory ability of patient with early onset of the diseases(319). Pharmacologically, the phytochemical was found to be a potential anticancer, antimutagenic, anti-inflammatory, antiproliferative and antiatherogenic agent(320).

2. Anti-inflammatory effects(320)
Neuroinflammation is considered as a constant event in Alzheimer's disease (AD), with no evidences for its direct involvement in development(322). In diabetic mice model, naringenin exhibited its anti inflammatory activity in  lowering blood glucose and urea nitrogen, increasing insulin level and creatinine clearance(321), probably through inhibition of iNOS protein and anti inflammatory pathways(323).

3. Immunity

Adaptive and innate immune deficit were shown to associate with cognitive dysfunction in patients with AD and mild cognitive impairment (MCI)(325). Naringenin, stimulated the production T cells in regulating the immune system, in suppression of  allergies and autoimmune diseases(324) which are considered as Alzheimer's and Parkinson's disease variants(326).

The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for 
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

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References
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375
(314) http://www.ncbi.nlm.nih.gov/pubmed/18812031
(315) http://www.ncbi.nlm.nih.gov/pubmed/24727881
(316) http://www.ncbi.nlm.nih.gov/pubmed/24359497
(317) http://www.ncbi.nlm.nih.gov/pubmed/20394007
(318) http://www.ncbi.nlm.nih.gov/pubmed/22898296
(318) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(319) http://www.ncbi.nlm.nih.gov/pubmed/24337945
(320) http://www.ncbi.nlm.nih.gov/pubmed/25501296 
(321) http://www.ncbi.nlm.nih.gov/pubmed/22117528
(322) http://www.ncbi.nlm.nih.gov/pubmed/23841061

(323) http://www.ncbi.nlm.nih.gov/pubmed/18274639
(324) http://www.ncbi.nlm.nih.gov/pubmed/22324845
(325) http://www.ncbi.nlm.nih.gov/pubmed/25201785
(326) http://www.ncbi.nlm.nih.gov/pubmed/24786080

The Best, and Healthy recipe: Home made pesto

Posted By Kyle J. Norton 
  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca 

Pesto is useful to have on hand. It can be tossed with pasta to make Kid's Pesto salad or used in variety of different sandwiches. If your school is nut-free, simply omit the pine nuts---the pesto is delicious this way too! Extra pesto can be frozen in ice cube trays
1/2 cup packed fresh basil leaves
1 cup grated Parmesan cheese
1/2 cup pine nut(optional)
2 garlic cloves
2-4 tbsp. extra virgin olive oil
In bowl of food processor, process basil, Parmesan, pine nuts(if using) and garlic until finely minced. With processor running, slowly pour olive oil through feeding tube and process until smooth consistently is reached.
Yield approximately 2 cups.Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca  
  

Thursday, 1 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemical Rosemarinol

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
A. Rosemarinol

Rosemarinol is a phytochemical monophenols, found in essential oil of labiate herbs like rosemary and in variety of other plants.
1. Retard autoxidation
Rosemary extract rich in carnosic acid showed a significantly retarded autoxidation, in the fish oil undergoes microencapsulation process, according to the North University(307).


2. Anti-inflammatory effects
The extract of rosemary leaves from supercritical fluid extraction showed a high inhibitory effect on lipid peroxidation, through suppression of the LPS-induced production of nitric oxide (NO)(308) and maintaining oxidative stability(313)

3. Antioxidant defenses

 Rosemary extract enhances antioxidant defenses and improves antioxidant status in aged rats in attenuation of lipid peroxidation and ROS levels through its antioxidant enzyme activity(309). The extract also showed to exhibit its antioxidant effect against the proliferation of irregular cell growth such as human leukemia and breast carcinoma cells(312).

The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for 
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   
 
References
(307) http://www.ncbi.nlm.nih.gov/pubmed/21447601
(308) http://www.ncbi.nlm.nih.gov/pubmed/21375325
(309) http://www.ncbi.nlm.nih.gov/pubmed/19289162
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375

The Best, Healthy and Hot recipe: Chilli mayonnaise

Posted By Kyle J. Norton 
  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca 

Chili mayonnaise is an ingredient in our flank steak. sandwich below and is also delicious in chicken salad sandwiches.
2 tbsp. mayonnaise
1 tsp. Asian garlic chili sauce or sweet chili sauce
In small bowl, combine ingredients thoroughly
Yield approximately 2 tbsp. 

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca  
 

Wednesday, 31 December 2014

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Common Free Radical Scavengers

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
B. Antioxidants and Dementia 
B.3. Common Free Radical Scavengers 
1. Bilirubin
Bilirubin is a prosthetic group with a unique function in breaking down molecules into smaller units for releasing energy, excreted in bile and urine(263). As a cellular antioxidant, it may protect against diseases associated with oxidative stress, through mildly elevated serum bilirubin levels and activation of heme oxygenase(264) and revert to biliverdin, a green tetrapyrrolic bile pigment, through antioxidant redox cycle in inhibition of the effects of mutagens when oxidized(265). A significant reduction of levels of bilirubin, has shown to associate to patients with Alzheimer's disease (AD)(266).

2. Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, some bacteria. The antioxidant has been under intense scrutiny studies for finding of their potential in modulated chronic disease risk and prevention of vitamin A deficiency(267). Plasma levels of HDL and carotenoids have shown to lower in patients with dementia related vascular disorders(268) and Alzheimer's disease(AD)(269).

Beta-Carotene, an organic compound is classified as a terpenoid, a strongly-coloured red-orange pigment in plants and fruits.
 Beta-Carotene is not toxic and stored in liver for the production of vitamin A(270) shown to inhibit cancer cell in experiment(271)(272). Its anti oxidative effects has shown to cover the main pathways for formation, transformation, and decay of free radicals(273), through  relation to the antioxidant/pro-oxidant properties(274). According to Yale University, the decreased non-enzymatic antioxidants in blood, including β-carotene showed a significant oxidative damage in the process of neurodegeneration(275).

3. Flavonoids
Flavonoid also known as Vitamin P and citrinare, is a yellow pigments having a structure similar to that of flavones occurred in varies plants. The antioxidant has been in human history for over thousands of years and discovered by A. S. Szent-Gyorgi in 1930. Vitamin C and flavonoids combination has shown to expressed wound healing in animal model(276).

Flavonoids process a property as antioxidants in inhibition of  cell growth, differentiation and development, and overexpressed in gastric cancer, colorectal cancer, pancreatic cancer, etc., probably through cell cycle arrest and induced apoptosis(277). Intake of antioxidant flavonoids is associated  to the reduced  risk of incident dementia(278)and mild cognitive impairment(279).

Although nitric oxide is considered a free radical produced by immune system to destroy microbial(281) and cancerous cells(282)(283). Over produced NO, showed to  induce inflammation(280), flavonoids inhibit NO production of peroxynitrite(284) which is found to induce mitochondrial dysfunction associated with PD progression(285) for prevention of the cause of inappropriate damage to blood and tissues(284).

4. Vitamin A, C, E
a. Vitamin A
Vitamin A occurred in the form retinol is best known for its function in maintaining a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system(286). The vitamin also acts as an the major peroxyl radical scavenger role in biological lipid phases such as membranes or low-density lipoproteins (LDL)(291)(288), including incidence of bronchopulmonary dysplasia (BPD) with respiratory failure(290). Prevention of its depletion in fighting the increased free radicals activity by radiation(287), and enhancement of the productions of insulin pancreas(289).

b. Vitamin C
Vitamin C beside, presences in aqueous compartments (e.g. cytosol, plasma, and other body fluids)(292) plays an important role  in synthesis of collagen, carnitine, catecholamine and the neurotransmitter norepinephrine(293). As an water soluble vitamin, vitamin C can be easily carry in blood, operate in much of the part of body. By recycling vitamin E, vitamin C also helps to fight against forming of free radicals(294). By enhancing the immune system(295)(296), it promotes against the microbial and viral(298) and irregular cell growth causes of infection and inflammation(297).
Vitamin C also is a free radical scavenger in inhibiting pollution cause of oxidation(299).

c. Vitamin E
Vitamin E is used to refer to a group of fat-soluble compounds, including  both tocopherols and tocotrienols(300) discovered by researchers Herbert Evans and Katherine Bishop. The viutamin beside is important in protecting muscle weakness(300), repairing damage tissues(302) caused by oxidation(303), and promoting blood clotting in healing wound(302), etc. It also is one of powerful antioxidant, moved into the fatty medium to prevent lipid peroxidation(301), inhibited free radicals chain reactions by curtailing them before they can start(304) and prevented or delayed cognitive decline  tested in clinical trials in both ageing population of and mild cognitive impairment in patients with Alzheimer's disease (AD)(306), according to R & D Human Nutrition and Health(305).

5. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   
 

References(263) http://www.ncbi.nlm.nih.gov/pubmed/24151358
(264) http://www.ncbi.nlm.nih.gov/pubmed/19754364
(265) http://www.ncbi.nlm.nih.gov/pubmed/22438843
(266) http://www.ncbi.nlm.nih.gov/pubmed/16534775
(267) http://www.ncbi.nlm.nih.gov/pubmed/8621054
(268) http://www.ncbi.nlm.nih.gov/pubmed/24448787
(269) http://www.ncbi.nlm.nih.gov/pubmed/24582848
(270) http://www.ncbi.nlm.nih.gov/pubmed/17665093
(271) http://www.ncbi.nlm.nih.gov/pubmed/8127329
(272) http://www.ncbi.nlm.nih.gov/pubmed/7959271
(273) http://www.ncbi.nlm.nih.gov/pubmed/8529916
(274) http://www.ncbi.nlm.nih.gov/pubmed/12630889
(275) http://www.ncbi.nlm.nih.gov/pubmed/23867235
(276) http://www.ncbi.nlm.nih.gov/pubmed/16633732
(277) http://www.ncbi.nlm.nih.gov/pubmed/24707875
(278) http://www.ncbi.nlm.nih.gov/pubmed/10959944
(279) http://www.ncbi.nlm.nih.gov/pubmed/25515512
(280) http://www.ncbi.nlm.nih.gov/pubmed/11515807
(281) http://www.ncbi.nlm.nih.gov/pubmed/15189992
(282) http://www.ncbi.nlm.nih.gov/pubmed/25519577
(283) http://www.ncbi.nlm.nih.gov/pubmed/12528889
(284) http://www.ncbi.nlm.nih.gov/pubmed/10660664
(285) http://www.ncbi.nlm.nih.gov/pubmed/17936517
(286) http://www.ncbi.nlm.nih.gov/pubmed/24662164
(287) http://www.ncbi.nlm.nih.gov/pubmed/24583267
(288) http://www.ncbi.nlm.nih.gov/pubmed/10926898
(289) http://www.ncbi.nlm.nih.gov/pubmed/25451926
(290) http://www.ncbi.nlm.nih.gov/pubmed/24388327
(291) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(292) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(293) http://www.ncbi.nlm.nih.gov/pubmed/23177992
(294) http://www.ncbi.nlm.nih.gov/pubmed/12841645
(295) http://www.ncbi.nlm.nih.gov/pubmed/6604680
(296) http://www.ncbi.nlm.nih.gov/pubmed/20515554
(297) http://www.ncbi.nlm.nih.gov/pubmed/24766384
(298) http://www.ncbi.nlm.nih.gov/pubmed/23988864
(299) http://www.ncbi.nlm.nih.gov/pubmed/13701588
(300) http://www.ncbi.nlm.nih.gov/pubmed/10385606
(301) http://www.ncbi.nlm.nih.gov/pubmed/11579997
(302) http://www.ncbi.nlm.nih.gov/pubmed/24524083
(303) http://www.ncbi.nlm.nih.gov/pubmed/1897277
(304) http://www.ncbi.nlm.nih.gov/pubmed/15593395
(305) http://www.ncbi.nlm.nih.gov/pubmed/25460513