By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is
the loss of mental ability, severe enough to interfere with people's
every life and Alzheimer's disease is the most common type of dementia
in aging people.
V. Preventions
C. Phytochemicals Against Dementia
C.2. Gingerole
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in
fresh ginger. and in variety of other plants. The herb has been used
for treatment of nausea and vomiting of pregnancy, motion sickness,
rheumatoid arthritis, relieve migraine, etc. in folk medicine.
1. Antioxidant and anti-inflammatory effects
Chemical
constituents of
Zingiber officinale Rosc.(Zingiberaceae) showed to attenuate oxidative
stress, through its scavenging, and inhibiting superoxide and hydroxyl
radicals of ROS species(310), via nephroprotective
effect on mediation of oxidative stress, inflammatory processes, and
renal dysfunction(311).
2. Dementia
Ginger(70%
aqueous/methanolic extract of dried ginger (Zo.Cr)) beside induced
spasmolytic activity in stomach fundus in treating dementia in South
Asia, it also inhibited butyrylcholinesterase (BuChE) in improvement of
cognitive performance patients with dementia(4) and Vascular dementia (VaD)(315), probably through cholinergic anti-inflammatory pathway in reduced production of amyloid-β(316).
C.3. Naringenin
Naringenin, a flavanone, belonging to the red, blue, purple
pigments of Flavonoids (polyphenols) found predominantly in citrus
fruits is considered as one of powerful antioxidant with many health
benefits.
1. Antioxidant, free radical scavenging
Naringin
showed to reduce DNA damage through its antioxidant capacities in
scavenging free radicals hydroxyl and superoxide(317). Cognitively, naringenin
ameliorates Alzheimer's disease (AD)-type neurodegeneration(318) by
improving learning and memory ability of patient with early onset of the
diseases(319). Pharmacologically, the phytochemical was found to be a
potential anticancer, antimutagenic, anti-inflammatory, antiproliferative and antiatherogenic agent(320).
2. Anti-inflammatory effects(320)
Neuroinflammation
is considered as a constant event in Alzheimer's disease (AD), with no
evidences for its direct involvement in development(322). In diabetic mice model, naringenin
exhibited its anti inflammatory activity in lowering blood glucose and
urea nitrogen, increasing insulin level and creatinine clearance(321),
probably through inhibition of iNOS protein and anti inflammatory pathways(323).
3. Immunity
Adaptive and innate immune deficit were shown to
associate with cognitive dysfunction in patients with AD and mild
cognitive impairment (MCI)(325). Naringenin,
stimulated the production T cells in regulating the immune system, in
suppression of allergies and autoimmune diseases(324) which are
considered as Alzheimer's and Parkinson's disease variants(326).
The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375
(314) http://www.ncbi.nlm.nih.gov/pubmed/18812031
(315) http://www.ncbi.nlm.nih.gov/pubmed/24727881
(316) http://www.ncbi.nlm.nih.gov/pubmed/24359497
(317) http://www.ncbi.nlm.nih.gov/pubmed/20394007
(318) http://www.ncbi.nlm.nih.gov/pubmed/22898296
(318) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(319) http://www.ncbi.nlm.nih.gov/pubmed/24337945
(320) http://www.ncbi.nlm.nih.gov/pubmed/25501296
(321) http://www.ncbi.nlm.nih.gov/pubmed/22117528
(322) http://www.ncbi.nlm.nih.gov/pubmed/23841061
(323) http://www.ncbi.nlm.nih.gov/pubmed/18274639
(324) http://www.ncbi.nlm.nih.gov/pubmed/22324845
(325) http://www.ncbi.nlm.nih.gov/pubmed/25201785
(326) http://www.ncbi.nlm.nih.gov/pubmed/24786080
Friday, 2 January 2015
The Best, and Healthy recipe: Home made pesto
Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca
Pesto is useful to have on hand. It can be tossed with pasta to make Kid's Pesto salad or used in variety of different sandwiches. If your school is nut-free, simply omit the pine nuts---the pesto is delicious this way too! Extra pesto can be frozen in ice cube trays
1/2 cup packed fresh basil leaves
1 cup grated Parmesan cheese
1/2 cup pine nut(optional)
2 garlic cloves
2-4 tbsp. extra virgin olive oil
In bowl of food processor, process basil, Parmesan, pine nuts(if using) and garlic until finely minced. With processor running, slowly pour olive oil through feeding tube and process until smooth consistently is reached.
Yield approximately 2 cups.Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca
Pesto is useful to have on hand. It can be tossed with pasta to make Kid's Pesto salad or used in variety of different sandwiches. If your school is nut-free, simply omit the pine nuts---the pesto is delicious this way too! Extra pesto can be frozen in ice cube trays
1/2 cup packed fresh basil leaves
1 cup grated Parmesan cheese
1/2 cup pine nut(optional)
2 garlic cloves
2-4 tbsp. extra virgin olive oil
In bowl of food processor, process basil, Parmesan, pine nuts(if using) and garlic until finely minced. With processor running, slowly pour olive oil through feeding tube and process until smooth consistently is reached.
Yield approximately 2 cups.Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Thursday, 1 January 2015
(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemical Rosemarinol
By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
C. Phytochemicals Against Dementia
A. Rosemarinol
Rosemarinol is a phytochemical monophenols, found in essential oil of labiate herbs like rosemary and in variety of other plants.
1. Retard autoxidation
Rosemary extract rich in carnosic acid showed a significantly retarded autoxidation, in the fish oil undergoes microencapsulation process, according to the North University(307).
2. Anti-inflammatory effects
The extract of rosemary leaves from supercritical fluid extraction showed a high inhibitory effect on lipid peroxidation, through suppression of the LPS-induced production of nitric oxide (NO)(308) and maintaining oxidative stability(313)
3. Antioxidant defenses
Rosemary extract enhances antioxidant defenses and improves antioxidant status in aged rats in attenuation of lipid peroxidation and ROS levels through its antioxidant enzyme activity(309). The extract also showed to exhibit its antioxidant effect against the proliferation of irregular cell growth such as human leukemia and breast carcinoma cells(312).
The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(307) http://www.ncbi.nlm.nih.gov/pubmed/21447601
(308) http://www.ncbi.nlm.nih.gov/pubmed/21375325
(309) http://www.ncbi.nlm.nih.gov/pubmed/19289162
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
C. Phytochemicals Against Dementia
A. Rosemarinol
Rosemarinol is a phytochemical monophenols, found in essential oil of labiate herbs like rosemary and in variety of other plants.
1. Retard autoxidation
Rosemary extract rich in carnosic acid showed a significantly retarded autoxidation, in the fish oil undergoes microencapsulation process, according to the North University(307).
2. Anti-inflammatory effects
The extract of rosemary leaves from supercritical fluid extraction showed a high inhibitory effect on lipid peroxidation, through suppression of the LPS-induced production of nitric oxide (NO)(308) and maintaining oxidative stability(313)
3. Antioxidant defenses
Rosemary extract enhances antioxidant defenses and improves antioxidant status in aged rats in attenuation of lipid peroxidation and ROS levels through its antioxidant enzyme activity(309). The extract also showed to exhibit its antioxidant effect against the proliferation of irregular cell growth such as human leukemia and breast carcinoma cells(312).
The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(307) http://www.ncbi.nlm.nih.gov/pubmed/21447601
(308) http://www.ncbi.nlm.nih.gov/pubmed/21375325
(309) http://www.ncbi.nlm.nih.gov/pubmed/19289162
(310) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(311) http://www.ncbi.nlm.nih.gov/pubmed/24395230
(312) http://www.ncbi.nlm.nih.gov/pubmed/17487414
(313) http://www.ncbi.nlm.nih.gov/pubmed/25214375
The Best, Healthy and Hot recipe: Chilli mayonnaise
Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca
Chili mayonnaise is an ingredient in our flank steak. sandwich below and is also delicious in chicken salad sandwiches.
2 tbsp. mayonnaise
1 tsp. Asian garlic chili sauce or sweet chili sauce
In small bowl, combine ingredients thoroughly
Yield approximately 2 tbsp.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca
Chili mayonnaise is an ingredient in our flank steak. sandwich below and is also delicious in chicken salad sandwiches.
2 tbsp. mayonnaise
1 tsp. Asian garlic chili sauce or sweet chili sauce
In small bowl, combine ingredients thoroughly
Yield approximately 2 tbsp.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Wednesday, 31 December 2014
(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Common Free Radical Scavengers
By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
B. Antioxidants and Dementia
B.3. Common Free Radical Scavengers
1. Bilirubin
Bilirubin is a prosthetic group with a unique function in breaking down molecules into smaller units for releasing energy, excreted in bile and urine(263). As a cellular antioxidant, it may protect against diseases associated with oxidative stress, through mildly elevated serum bilirubin levels and activation of heme oxygenase(264) and revert to biliverdin, a green tetrapyrrolic bile pigment, through antioxidant redox cycle in inhibition of the effects of mutagens when oxidized(265). A significant reduction of levels of bilirubin, has shown to associate to patients with Alzheimer's disease (AD)(266).
2. Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, some bacteria. The antioxidant has been under intense scrutiny studies for finding of their potential in modulated chronic disease risk and prevention of vitamin A deficiency(267). Plasma levels of HDL and carotenoids have shown to lower in patients with dementia related vascular disorders(268) and Alzheimer's disease(AD)(269).
Beta-Carotene, an organic compound is classified as a terpenoid, a strongly-coloured red-orange pigment in plants and fruits.
Beta-Carotene is not toxic and stored in liver for the production of vitamin A(270) shown to inhibit cancer cell in experiment(271)(272). Its anti oxidative effects has shown to cover the main pathways for formation, transformation, and decay of free radicals(273), through relation to the antioxidant/pro-oxidant properties(274). According to Yale University, the decreased non-enzymatic antioxidants in blood, including β-carotene showed a significant oxidative damage in the process of neurodegeneration(275).
3. Flavonoids
Flavonoid also known as Vitamin P and citrinare, is a yellow pigments having a structure similar to that of flavones occurred in varies plants. The antioxidant has been in human history for over thousands of years and discovered by A. S. Szent-Gyorgi in 1930. Vitamin C and flavonoids combination has shown to expressed wound healing in animal model(276).
Flavonoids process a property as antioxidants in inhibition of cell growth, differentiation and development, and overexpressed in gastric cancer, colorectal cancer, pancreatic cancer, etc., probably through cell cycle arrest and induced apoptosis(277). Intake of antioxidant flavonoids is associated to the reduced risk of incident dementia(278)and mild cognitive impairment(279).
Although nitric oxide is considered a free radical produced by immune system to destroy microbial(281) and cancerous cells(282)(283). Over produced NO, showed to induce inflammation(280), flavonoids inhibit NO production of peroxynitrite(284) which is found to induce mitochondrial dysfunction associated with PD progression(285) for prevention of the cause of inappropriate damage to blood and tissues(284).
4. Vitamin A, C, E
a. Vitamin A
Vitamin A occurred in the form retinol is best known for its function in maintaining a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system(286). The vitamin also acts as an the major peroxyl radical scavenger role in biological lipid phases such as membranes or low-density lipoproteins (LDL)(291)(288), including incidence of bronchopulmonary dysplasia (BPD) with respiratory failure(290). Prevention of its depletion in fighting the increased free radicals activity by radiation(287), and enhancement of the productions of insulin pancreas(289).
b. Vitamin C
Vitamin C beside, presences in aqueous compartments (e.g. cytosol, plasma, and other body fluids)(292) plays an important role in synthesis of collagen, carnitine, catecholamine and the neurotransmitter norepinephrine(293). As an water soluble vitamin, vitamin C can be easily carry in blood, operate in much of the part of body. By recycling vitamin E, vitamin C also helps to fight against forming of free radicals(294). By enhancing the immune system(295)(296), it promotes against the microbial and viral(298) and irregular cell growth causes of infection and inflammation(297).
Vitamin C also is a free radical scavenger in inhibiting pollution cause of oxidation(299).
c. Vitamin E
Vitamin E is used to refer to a group of fat-soluble compounds, including both tocopherols and tocotrienols(300) discovered by researchers Herbert Evans and Katherine Bishop. The viutamin beside is important in protecting muscle weakness(300), repairing damage tissues(302) caused by oxidation(303), and promoting blood clotting in healing wound(302), etc. It also is one of powerful antioxidant, moved into the fatty medium to prevent lipid peroxidation(301), inhibited free radicals chain reactions by curtailing them before they can start(304) and prevented or delayed cognitive decline tested in clinical trials in both ageing population of and mild cognitive impairment in patients with Alzheimer's disease (AD)(306), according to R & D Human Nutrition and Health(305).
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References(263) http://www.ncbi.nlm.nih.gov/pubmed/24151358
(264) http://www.ncbi.nlm.nih.gov/pubmed/19754364
(265) http://www.ncbi.nlm.nih.gov/pubmed/22438843
(266) http://www.ncbi.nlm.nih.gov/pubmed/16534775
(267) http://www.ncbi.nlm.nih.gov/pubmed/8621054
(268) http://www.ncbi.nlm.nih.gov/pubmed/24448787
(269) http://www.ncbi.nlm.nih.gov/pubmed/24582848
(270) http://www.ncbi.nlm.nih.gov/pubmed/17665093
(271) http://www.ncbi.nlm.nih.gov/pubmed/8127329
(272) http://www.ncbi.nlm.nih.gov/pubmed/7959271
(273) http://www.ncbi.nlm.nih.gov/pubmed/8529916
(274) http://www.ncbi.nlm.nih.gov/pubmed/12630889
(275) http://www.ncbi.nlm.nih.gov/pubmed/23867235
(276) http://www.ncbi.nlm.nih.gov/pubmed/16633732
(277) http://www.ncbi.nlm.nih.gov/pubmed/24707875
(278) http://www.ncbi.nlm.nih.gov/pubmed/10959944
(279) http://www.ncbi.nlm.nih.gov/pubmed/25515512
(280) http://www.ncbi.nlm.nih.gov/pubmed/11515807
(281) http://www.ncbi.nlm.nih.gov/pubmed/15189992
(282) http://www.ncbi.nlm.nih.gov/pubmed/25519577
(283) http://www.ncbi.nlm.nih.gov/pubmed/12528889
(284) http://www.ncbi.nlm.nih.gov/pubmed/10660664
(285) http://www.ncbi.nlm.nih.gov/pubmed/17936517
(286) http://www.ncbi.nlm.nih.gov/pubmed/24662164
(287) http://www.ncbi.nlm.nih.gov/pubmed/24583267
(288) http://www.ncbi.nlm.nih.gov/pubmed/10926898
(289) http://www.ncbi.nlm.nih.gov/pubmed/25451926
(290) http://www.ncbi.nlm.nih.gov/pubmed/24388327
(291) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(292) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(293) http://www.ncbi.nlm.nih.gov/pubmed/23177992
(294) http://www.ncbi.nlm.nih.gov/pubmed/12841645
(295) http://www.ncbi.nlm.nih.gov/pubmed/6604680
(296) http://www.ncbi.nlm.nih.gov/pubmed/20515554
(297) http://www.ncbi.nlm.nih.gov/pubmed/24766384
(298) http://www.ncbi.nlm.nih.gov/pubmed/23988864
(299) http://www.ncbi.nlm.nih.gov/pubmed/13701588
(300) http://www.ncbi.nlm.nih.gov/pubmed/10385606
(301) http://www.ncbi.nlm.nih.gov/pubmed/11579997
(302) http://www.ncbi.nlm.nih.gov/pubmed/24524083
(303) http://www.ncbi.nlm.nih.gov/pubmed/1897277
(304) http://www.ncbi.nlm.nih.gov/pubmed/15593395
(305) http://www.ncbi.nlm.nih.gov/pubmed/25460513
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
B. Antioxidants and Dementia
B.3. Common Free Radical Scavengers
1. Bilirubin
Bilirubin is a prosthetic group with a unique function in breaking down molecules into smaller units for releasing energy, excreted in bile and urine(263). As a cellular antioxidant, it may protect against diseases associated with oxidative stress, through mildly elevated serum bilirubin levels and activation of heme oxygenase(264) and revert to biliverdin, a green tetrapyrrolic bile pigment, through antioxidant redox cycle in inhibition of the effects of mutagens when oxidized(265). A significant reduction of levels of bilirubin, has shown to associate to patients with Alzheimer's disease (AD)(266).
2. Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, some bacteria. The antioxidant has been under intense scrutiny studies for finding of their potential in modulated chronic disease risk and prevention of vitamin A deficiency(267). Plasma levels of HDL and carotenoids have shown to lower in patients with dementia related vascular disorders(268) and Alzheimer's disease(AD)(269).
Beta-Carotene, an organic compound is classified as a terpenoid, a strongly-coloured red-orange pigment in plants and fruits.
Beta-Carotene is not toxic and stored in liver for the production of vitamin A(270) shown to inhibit cancer cell in experiment(271)(272). Its anti oxidative effects has shown to cover the main pathways for formation, transformation, and decay of free radicals(273), through relation to the antioxidant/pro-oxidant properties(274). According to Yale University, the decreased non-enzymatic antioxidants in blood, including β-carotene showed a significant oxidative damage in the process of neurodegeneration(275).
3. Flavonoids
Flavonoid also known as Vitamin P and citrinare, is a yellow pigments having a structure similar to that of flavones occurred in varies plants. The antioxidant has been in human history for over thousands of years and discovered by A. S. Szent-Gyorgi in 1930. Vitamin C and flavonoids combination has shown to expressed wound healing in animal model(276).
Flavonoids process a property as antioxidants in inhibition of cell growth, differentiation and development, and overexpressed in gastric cancer, colorectal cancer, pancreatic cancer, etc., probably through cell cycle arrest and induced apoptosis(277). Intake of antioxidant flavonoids is associated to the reduced risk of incident dementia(278)and mild cognitive impairment(279).
Although nitric oxide is considered a free radical produced by immune system to destroy microbial(281) and cancerous cells(282)(283). Over produced NO, showed to induce inflammation(280), flavonoids inhibit NO production of peroxynitrite(284) which is found to induce mitochondrial dysfunction associated with PD progression(285) for prevention of the cause of inappropriate damage to blood and tissues(284).
4. Vitamin A, C, E
a. Vitamin A
Vitamin A occurred in the form retinol is best known for its function in maintaining a critical role in vertebrate development, cell differentiation, reproduction, vision and immune system(286). The vitamin also acts as an the major peroxyl radical scavenger role in biological lipid phases such as membranes or low-density lipoproteins (LDL)(291)(288), including incidence of bronchopulmonary dysplasia (BPD) with respiratory failure(290). Prevention of its depletion in fighting the increased free radicals activity by radiation(287), and enhancement of the productions of insulin pancreas(289).
b. Vitamin C
Vitamin C beside, presences in aqueous compartments (e.g. cytosol, plasma, and other body fluids)(292) plays an important role in synthesis of collagen, carnitine, catecholamine and the neurotransmitter norepinephrine(293). As an water soluble vitamin, vitamin C can be easily carry in blood, operate in much of the part of body. By recycling vitamin E, vitamin C also helps to fight against forming of free radicals(294). By enhancing the immune system(295)(296), it promotes against the microbial and viral(298) and irregular cell growth causes of infection and inflammation(297).
Vitamin C also is a free radical scavenger in inhibiting pollution cause of oxidation(299).
c. Vitamin E
Vitamin E is used to refer to a group of fat-soluble compounds, including both tocopherols and tocotrienols(300) discovered by researchers Herbert Evans and Katherine Bishop. The viutamin beside is important in protecting muscle weakness(300), repairing damage tissues(302) caused by oxidation(303), and promoting blood clotting in healing wound(302), etc. It also is one of powerful antioxidant, moved into the fatty medium to prevent lipid peroxidation(301), inhibited free radicals chain reactions by curtailing them before they can start(304) and prevented or delayed cognitive decline tested in clinical trials in both ageing population of and mild cognitive impairment in patients with Alzheimer's disease (AD)(306), according to R & D Human Nutrition and Health(305).
5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References(263) http://www.ncbi.nlm.nih.gov/pubmed/24151358
(264) http://www.ncbi.nlm.nih.gov/pubmed/19754364
(265) http://www.ncbi.nlm.nih.gov/pubmed/22438843
(266) http://www.ncbi.nlm.nih.gov/pubmed/16534775
(267) http://www.ncbi.nlm.nih.gov/pubmed/8621054
(268) http://www.ncbi.nlm.nih.gov/pubmed/24448787
(269) http://www.ncbi.nlm.nih.gov/pubmed/24582848
(270) http://www.ncbi.nlm.nih.gov/pubmed/17665093
(271) http://www.ncbi.nlm.nih.gov/pubmed/8127329
(272) http://www.ncbi.nlm.nih.gov/pubmed/7959271
(273) http://www.ncbi.nlm.nih.gov/pubmed/8529916
(274) http://www.ncbi.nlm.nih.gov/pubmed/12630889
(275) http://www.ncbi.nlm.nih.gov/pubmed/23867235
(276) http://www.ncbi.nlm.nih.gov/pubmed/16633732
(277) http://www.ncbi.nlm.nih.gov/pubmed/24707875
(278) http://www.ncbi.nlm.nih.gov/pubmed/10959944
(279) http://www.ncbi.nlm.nih.gov/pubmed/25515512
(280) http://www.ncbi.nlm.nih.gov/pubmed/11515807
(281) http://www.ncbi.nlm.nih.gov/pubmed/15189992
(282) http://www.ncbi.nlm.nih.gov/pubmed/25519577
(283) http://www.ncbi.nlm.nih.gov/pubmed/12528889
(284) http://www.ncbi.nlm.nih.gov/pubmed/10660664
(285) http://www.ncbi.nlm.nih.gov/pubmed/17936517
(286) http://www.ncbi.nlm.nih.gov/pubmed/24662164
(287) http://www.ncbi.nlm.nih.gov/pubmed/24583267
(288) http://www.ncbi.nlm.nih.gov/pubmed/10926898
(289) http://www.ncbi.nlm.nih.gov/pubmed/25451926
(290) http://www.ncbi.nlm.nih.gov/pubmed/24388327
(291) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(292) http://www.ncbi.nlm.nih.gov/pubmed/1444060
(293) http://www.ncbi.nlm.nih.gov/pubmed/23177992
(294) http://www.ncbi.nlm.nih.gov/pubmed/12841645
(295) http://www.ncbi.nlm.nih.gov/pubmed/6604680
(296) http://www.ncbi.nlm.nih.gov/pubmed/20515554
(297) http://www.ncbi.nlm.nih.gov/pubmed/24766384
(298) http://www.ncbi.nlm.nih.gov/pubmed/23988864
(299) http://www.ncbi.nlm.nih.gov/pubmed/13701588
(300) http://www.ncbi.nlm.nih.gov/pubmed/10385606
(301) http://www.ncbi.nlm.nih.gov/pubmed/11579997
(302) http://www.ncbi.nlm.nih.gov/pubmed/24524083
(303) http://www.ncbi.nlm.nih.gov/pubmed/1897277
(304) http://www.ncbi.nlm.nih.gov/pubmed/15593395
(305) http://www.ncbi.nlm.nih.gov/pubmed/25460513
The Easy and Healthy recipe: Cucumber sandwich
Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca
This simple sandwich is ideal for young children. Dig out the cookie cutter to create a tantalizing treat. For variety you can add a few slices of sweet red pepper and/or romaine lettuce.
2 slices whole wheat bread
1 tsp. non hydrogenate margarine
2 tsp. mayonnaise
8 slices of cucumber, thinly sliced
Kosher salt and freshly ground pepper(optional)
The night organize ingredients and refrigerate.
In the morning, lightly toast bread slices and spread with margarine.
Spread 1 slice of bread with mayonnaise and top with cucumber. Srinkle lightly with salt and papper to taste(If using) and top with remaining slice of bread. Use cookie cutters to cutout fun shapes and pack in reusable containers.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Yield serves 1
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca
This simple sandwich is ideal for young children. Dig out the cookie cutter to create a tantalizing treat. For variety you can add a few slices of sweet red pepper and/or romaine lettuce.
2 slices whole wheat bread
1 tsp. non hydrogenate margarine
2 tsp. mayonnaise
8 slices of cucumber, thinly sliced
Kosher salt and freshly ground pepper(optional)
The night organize ingredients and refrigerate.
In the morning, lightly toast bread slices and spread with margarine.
Spread 1 slice of bread with mayonnaise and top with cucumber. Srinkle lightly with salt and papper to taste(If using) and top with remaining slice of bread. Use cookie cutters to cutout fun shapes and pack in reusable containers.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Yield serves 1
Tuesday, 30 December 2014
(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): The Preventive Metals Binding Proteins
By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
B. Antioxidants and Dementia
B.2. Metals binding proteins
1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood plays a role in iron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of superoxide anion radicals(231) and iron overload in the brain, liver, pancreas, and other organs(232).
2. Ferritin
Ferritin, the protein produced by almost all living organisms, acts as a component to fight against iron deficiency and iron overload(233)(234). In a soluble and non-toxic form, the protein is transported to the body needs, including organs(236) for enhancement of the immune system in the presence of an infection(237), proliferation of lymphoid and myeloid cells(235), cancer(238) and prevention of the infectious agent in attempt of binding iron to form free radicals(239) in most cellular oxidation reactions(239).
3. Lactoferrin
Lactoferrin, a multifunctional protein of the transferrin family, is one of the components of the immune system(240) of the body by fighting against foreign invasion of bacteria and virus(241)(242) and lipid oxidation(243) by inhibiting oxidation in a concentration-dependent manner even at concentrations beyond its capacity(244).
4. Metallothionein
Metallothionein, a family of cysteine-rich(24), low molecular weight proteins binds both physiological heavy metals(245) through detoxified fraction of accumulation(245). It also captures harmful superoxide and hydroxyl radicals(246) by binding the metal ions(247)(248) bounded to cysteine(249).
5. Transferrin
Transferrin, a glycoprotein binded iron very tightly but reversibly, enhances the immune system in fighting against infection, inflammation(250) by creating an environment low in free iron(251) that impedes cell oxidation(253)(254), through rapidly evolving sites reverse to bacterial binding in counteract bacterial iron piracy(250). Transferrin deformation and aggregation are found to associate to neurological disorders such as Parkinson's and Alzheimer's disease(252).
6. Hemoglobin
Hemoglobin, the protein molecule in red blood cells enhances the carrying of oxygen from the lungs to the body's tissues and return CO2 from the tissues to the lungs(255)(256). During oxidate stress, the cell membrane is protected by intraerythrocytic hemoglobin from the forming of free radicals(259), probably through regulating NO(258) and auxin homeostasis(257).
7. Myoglobin
Myoglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates. The binding of oxygen by myoglobin(260) through interaction with pathogens establishment of successful infection and survival is probably through peroxidase activity(261), thus reducing the free radicals damage caused by oxidate stress(261)(262).
8. Etc.
The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(227) http://www.ncbi.nlm.nih.gov/pubmed/10930377
(228) http://www.ncbi.nlm.nih.gov/pubmed/19769463
(229) http://www.ncbi.nlm.nih.gov/pubmed/22634395
(230) http://www.ncbi.nlm.nih.gov/pubmed/16673405
(231) http://www.ncbi.nlm.nih.gov/pubmed/24090962
(232) http://www.ncbi.nlm.nih.gov/pubmed/25280422
(233) http://www.ncbi.nlm.nih.gov/pubmed/24814729
(224) http://www.ncbi.nlm.nih.gov/pubmed/25501153
(225) http://www.ncbi.nlm.nih.gov/pubmed/25511255
(226) http://www.ncbi.nlm.nih.gov/pubmed/25052430
(227) http://www.ncbi.nlm.nih.gov/pubmed/25498860
(228) http://www.ncbi.nlm.nih.gov/pubmed/25464026
(229) http://www.ncbi.nlm.nih.gov/pubmed/20655381
(230) http://www.ncbi.nlm.nih.gov/pubmed/24921009
(231) http://www.ncbi.nlm.nih.gov/pubmed/6284006
(232) http://www.ncbi.nlm.nih.gov/pubmed/25089372
(233) http://www.ncbi.nlm.nih.gov/pubmed/4014070
(234) http://www.ncbi.nlm.nih.gov/pubmed/6830706
(235) http://www.ncbi.nlm.nih.gov/pubmed/18191543
(236) http://www.ncbi.nlm.nih.gov/pubmed/17459943
(237) http://www.ncbi.nlm.nih.gov/pubmed/19428486
(238) http://www.ncbi.nlm.nih.gov/pubmed/23891969
(239) http://www.ncbi.nlm.nih.gov/pubmed/22155779
(240) http://www.ncbi.nlm.nih.gov/pubmed/21847071
(241) http://www.ncbi.nlm.nih.gov/pubmed/25282173
(242) http://www.ncbi.nlm.nih.gov/pubmed/15222464
(243) http://www.ncbi.nlm.nih.gov/pubmed/22304665
(244) http://www.ncbi.nlm.nih.gov/pubmed/11052766
(245) http://www.ncbi.nlm.nih.gov/pubmed/25528420
(246) http://www.ncbi.nlm.nih.gov/pubmed/18561335
(247) http://www.ncbi.nlm.nih.gov/pubmed/16872588
(248) http://www.ncbi.nlm.nih.gov/pubmed/1342190
(249) http://www.ncbi.nlm.nih.gov/pubmed/24493013
(250) http://www.ncbi.nlm.nih.gov/pubmed/25504720
(251) http://www.ncbi.nlm.nih.gov/pubmed/12476940
(252) http://www.ncbi.nlm.nih.gov/pubmed/22119572
(253) http://www.ncbi.nlm.nih.gov/pubmed/7298642
(254) http://www.ncbi.nlm.nih.gov/pubmed/7925932
(255) http://www.ncbi.nlm.nih.gov/pubmed/23820271
(256) http://www.ncbi.nlm.nih.gov/pubmed/12683610
(257) http://www.ncbi.nlm.nih.gov/pubmed/24905914
(258) http://www.ncbi.nlm.nih.gov/pubmed/24815022
(259) http://www.ncbi.nlm.nih.gov/pubmed/20003712
(260) http://www.ncbi.nlm.nih.gov/pubmed/15756816
(260) http://www.ncbi.nlm.nih.gov/pubmed/1575681
(261) http://www.ncbi.nlm.nih.gov/pubmed/24885788
(262) http://www.ncbi.nlm.nih.gov/pubmed/24885788
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V. Preventions
B. Antioxidants and Dementia
B.2. Metals binding proteins
1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood plays a role in iron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of superoxide anion radicals(231) and iron overload in the brain, liver, pancreas, and other organs(232).
2. Ferritin
Ferritin, the protein produced by almost all living organisms, acts as a component to fight against iron deficiency and iron overload(233)(234). In a soluble and non-toxic form, the protein is transported to the body needs, including organs(236) for enhancement of the immune system in the presence of an infection(237), proliferation of lymphoid and myeloid cells(235), cancer(238) and prevention of the infectious agent in attempt of binding iron to form free radicals(239) in most cellular oxidation reactions(239).
3. Lactoferrin
Lactoferrin, a multifunctional protein of the transferrin family, is one of the components of the immune system(240) of the body by fighting against foreign invasion of bacteria and virus(241)(242) and lipid oxidation(243) by inhibiting oxidation in a concentration-dependent manner even at concentrations beyond its capacity(244).
4. Metallothionein
Metallothionein, a family of cysteine-rich(24), low molecular weight proteins binds both physiological heavy metals(245) through detoxified fraction of accumulation(245). It also captures harmful superoxide and hydroxyl radicals(246) by binding the metal ions(247)(248) bounded to cysteine(249).
5. Transferrin
Transferrin, a glycoprotein binded iron very tightly but reversibly, enhances the immune system in fighting against infection, inflammation(250) by creating an environment low in free iron(251) that impedes cell oxidation(253)(254), through rapidly evolving sites reverse to bacterial binding in counteract bacterial iron piracy(250). Transferrin deformation and aggregation are found to associate to neurological disorders such as Parkinson's and Alzheimer's disease(252).
6. Hemoglobin
Hemoglobin, the protein molecule in red blood cells enhances the carrying of oxygen from the lungs to the body's tissues and return CO2 from the tissues to the lungs(255)(256). During oxidate stress, the cell membrane is protected by intraerythrocytic hemoglobin from the forming of free radicals(259), probably through regulating NO(258) and auxin homeostasis(257).
7. Myoglobin
Myoglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates. The binding of oxygen by myoglobin(260) through interaction with pathogens establishment of successful infection and survival is probably through peroxidase activity(261), thus reducing the free radicals damage caused by oxidate stress(261)(262).
8. Etc.
The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(227) http://www.ncbi.nlm.nih.gov/pubmed/10930377
(228) http://www.ncbi.nlm.nih.gov/pubmed/19769463
(229) http://www.ncbi.nlm.nih.gov/pubmed/22634395
(230) http://www.ncbi.nlm.nih.gov/pubmed/16673405
(231) http://www.ncbi.nlm.nih.gov/pubmed/24090962
(232) http://www.ncbi.nlm.nih.gov/pubmed/25280422
(233) http://www.ncbi.nlm.nih.gov/pubmed/24814729
(224) http://www.ncbi.nlm.nih.gov/pubmed/25501153
(225) http://www.ncbi.nlm.nih.gov/pubmed/25511255
(226) http://www.ncbi.nlm.nih.gov/pubmed/25052430
(227) http://www.ncbi.nlm.nih.gov/pubmed/25498860
(228) http://www.ncbi.nlm.nih.gov/pubmed/25464026
(229) http://www.ncbi.nlm.nih.gov/pubmed/20655381
(230) http://www.ncbi.nlm.nih.gov/pubmed/24921009
(231) http://www.ncbi.nlm.nih.gov/pubmed/6284006
(232) http://www.ncbi.nlm.nih.gov/pubmed/25089372
(233) http://www.ncbi.nlm.nih.gov/pubmed/4014070
(234) http://www.ncbi.nlm.nih.gov/pubmed/6830706
(235) http://www.ncbi.nlm.nih.gov/pubmed/18191543
(236) http://www.ncbi.nlm.nih.gov/pubmed/17459943
(237) http://www.ncbi.nlm.nih.gov/pubmed/19428486
(238) http://www.ncbi.nlm.nih.gov/pubmed/23891969
(239) http://www.ncbi.nlm.nih.gov/pubmed/22155779
(240) http://www.ncbi.nlm.nih.gov/pubmed/21847071
(241) http://www.ncbi.nlm.nih.gov/pubmed/25282173
(242) http://www.ncbi.nlm.nih.gov/pubmed/15222464
(243) http://www.ncbi.nlm.nih.gov/pubmed/22304665
(244) http://www.ncbi.nlm.nih.gov/pubmed/11052766
(245) http://www.ncbi.nlm.nih.gov/pubmed/25528420
(246) http://www.ncbi.nlm.nih.gov/pubmed/18561335
(247) http://www.ncbi.nlm.nih.gov/pubmed/16872588
(248) http://www.ncbi.nlm.nih.gov/pubmed/1342190
(249) http://www.ncbi.nlm.nih.gov/pubmed/24493013
(250) http://www.ncbi.nlm.nih.gov/pubmed/25504720
(251) http://www.ncbi.nlm.nih.gov/pubmed/12476940
(252) http://www.ncbi.nlm.nih.gov/pubmed/22119572
(253) http://www.ncbi.nlm.nih.gov/pubmed/7298642
(254) http://www.ncbi.nlm.nih.gov/pubmed/7925932
(255) http://www.ncbi.nlm.nih.gov/pubmed/23820271
(256) http://www.ncbi.nlm.nih.gov/pubmed/12683610
(257) http://www.ncbi.nlm.nih.gov/pubmed/24905914
(258) http://www.ncbi.nlm.nih.gov/pubmed/24815022
(259) http://www.ncbi.nlm.nih.gov/pubmed/20003712
(260) http://www.ncbi.nlm.nih.gov/pubmed/15756816
(260) http://www.ncbi.nlm.nih.gov/pubmed/1575681
(261) http://www.ncbi.nlm.nih.gov/pubmed/24885788
(262) http://www.ncbi.nlm.nih.gov/pubmed/24885788
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