Premenstrual Syndrome(PMS) caused by Liver blood stagnation in Chinese Herbs Perspective

 By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Premenstrual syndrome effects over 70% to 90% of women before menopause in the US and less for women in Southeast Asia because of their difference in living style and social structure. It is defined as faulty function of the ovaries related to the women's menstrual cycle, it effects a women's physical and emotional state, and sometimes interferes with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts. In this article, we will discuss How Traditional Chinese Medicine Helps to Treat PMS.
Traditional Chinese medicine used over 4000 thousand years in treating women reproductive system disorder believed Pre menstrual syndrome is caused by

Liver blood stagnation, is a milder form of impaired blood flow(2) in the abdominal region(1) including uterus causes of  menstrual pain and cramps(1)(2) before the period. By releasing the blood stagnation,  in the abdomen, certain herbs have shown to relieve symptoms of PMS, including migraine(2).
1. Angelica root
 Angelica root is a queen for women reproductive system, used in traditional Chinese medicine in tonifying blood, promoting blood circulation(2), regulating menstruation(1), alleviating pain(2), and lubricating the bowels to relieve constipation(3), probably through its phytochemicalsè estrogenic(12)(13) and antiestrogenic(14) activities.
Angelica root also showed a protective effect against kidney injure(5)(6), radiation(7), cancers(8)(9)(15), osteoarthritis (OA)(10) and  to improve immunity(4), dementia(16), female sexual dysfunction (FSD), menopausal symptoms(17), menopausal symptoms(18), etc. in modern studies.
 
2. Peony (Shao Yao)
 Peony has been used in Chinese medicine in treating liver(20)(22)(27) blood stagnation(19) and induced blood flow by increasing the liver in blood formation(19) and promoting circulatory system for providing nutrients to our body need to nourish menstruation(20), relaxing spasm(22), relieving pain(22) and  liver dysfunction(20) causes of tension of nervous system, such as anxiety(30).

Peony also showed a protective effect against influenza(20)(21), inflammatory diseases(24)(25), diabetes(26)(28)and triglycerides accumlation(26), cancers(21)(23), and to promote would healing(29), etc.. in modern studies.

3. Spatholobus spp (Ji Xue Teng)
Spathholobus spp is a blood tonic medicine, used in TCM to treat reproductive system disorders caused by blood stagnation(37) or blood deficiency(38), through increasing the production of blood(34) and moving the blood(37) for alleviating menstrual pain and cramps(39).

Spatholobus spp (Ji Xue Teng) also showed a protective effect against osteoarthritis (OA)(31), cancers(32)(33), fungal infection(34). inflammatory diseases(35), neurodegenerative disorders(36), etc.. in modern studies.

4. Ligusticum wallichi (Chuan Xiong)
Ligustium wallichi is also a herb for tonified blood circulation, including the abdominal region, used in Chinese medicine as reproductive system(42) enhancing herb through unblock blood vessels(43), regulate menstruation(42).


Ligusticum wallichi (Chuan Xiong) also showed a protective effect in vasorelaxant activity(43); improved the Left Ventricular Ejection Fractionof central nervous system(44), against dementia(45)(49), atherosclerosis(46, renal tubule damage(47), inflammation(48), myocardial ischemic reperfusion(50), lens opacification(51), etc.. in modern studies.

5. Red sage roots (Dan Shen)
Red sage root is a main Chinese medicine used for treatment of blood stagnation(52) in the abdominal region by improving the blood circulation in the body including abdominal region and breaking up stagnation(52).

Red sage roots (Dan Shen) also showed a protective effect of CNS(56) and against injuries involving the cranium and intracranial structures (craniocerebral injury), degeneration of spinal disks in the neck (cervical spondylosis) and brain dysfunctions related to disease of the blood vessels (cerebrovascular diseases)(53), atherosclerosis(54), convulsant activit(55), hepatitis B(57), chronic fatigue syndrome (CFS)(58), benign prostatic hyperplasia (BPH)(59), etc. in modern studies.

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References
(1) Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect by Choi KO¹, Lee I, Paik SY, Kim DE, Lim JD, Kang WS, Ko S.(PubMed)
(2) Analgesic effect and mechanism of the three TCM-herbal drug-combination Tou Feng Yu pill on treatment of migraine by Li JC¹, Shen XF, Meng XL, Zhang Y, Lai XR.(PubMed)
(3) Chinese Angelica Root(Eastern medicine export company)
(4) Immunomodulatory activity of polysaccharide isolated from Angelica sinensis by Yang T¹, Jia M, Meng J, Wu H, Mei Q.(PubMed)
(5) [Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats].[Article in Chinese] by Sheng MX¹, Li JZ, Wang HY.(PubMed)
(6) [Adjustment effect of Radix Astragalus and Radix Angelicae sinensis on TNF-alpha and bFGF on renal injury induced by ischemia reperfusion in rabbit].

[Article in Chinese] by Xu XY¹, Li LH, Wu LS, Zhao CL, Lin HY.(PubMed)

(7) Water-soluble polysaccharides from Angelica sinensis (Oliv.) Diels: Preparation, characterization and bioactivity by Sun Y¹, Tang J, Gu X, Li D.(PubMed) 

(8) [Structural analysis and anti-tumor activity in vivo of polysaccharide APS-2a from Angelica sinensis].

[Article in Chinese] by Cao W¹, Li XQ, Hou Y, Fan HT, Zhang XN, Mei QB.(PubMed)

(9) Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis by Shang P¹, Qian AR, Yang TH, Jia M, Mei QB, Cho CH, Zhao WM, Chen ZN.(PubMed) 

(10) Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis by Qin J¹, Liu YS, Liu J, Li J, Tan Y, Li XJ, Magdalou J, Mei QB, Wang H, Chen LB.(PubMed) 

(11) Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity by Wen Y¹, Li J², Tan Y¹, Qin J¹, Xie X², Wang L¹, Mei Q³, Wang H⁴, Magdalou J⁵, Chen L⁶.(PubMed) 

(12)Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease by Choi RC¹, Zhu JT, Yung AW, Lee PS, Xu SL, Guo AJ, Zhu KY, Dong TT, Tsim KW.(PubMed)
(13) Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death by Zhu JT¹, Choi RC, Chu GK, Cheung AW, Gao QT, Li J, Jiang ZY, Dong TT, Tsim KW.(PubMed)
(14) Isoflavones: chemistry, analysis, functions and effects on health and cancer by Ko KP.(PubMed)

(15) Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells by Chang CJ¹, Chiu JH, Tseng LM, Chang CH, Chien TM, Wu CW, Lui WY.(PubMed)

(16) Traditional chinese medicine for senile dementia by Lin Z¹, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)

(17)Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women? by Mazaro-Costa R¹, Andersen ML, Hachul H, Tufik S.(PubMed) 

(18) The immediate effect of natural plant extract, Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. A preliminary report by Kupfersztain C¹, Rotem C, Fagot R, Kaplan B.(PubMed)

(19) Hemopoietic effect of extracts from constituent herbal medicines of Samul-tang on phenylhydrazine-induced hemolytic anemia in rats by Lee HW¹, Kim H¹, Ryuk JA¹, Kil KJ², Ko BS¹.(PubMed)
(20) Characterization of the anti-influenza activity of the Chinese herbal plant Paeonia lactiflora by Ho JY¹, Chang HW², Lin CF³, Liu CJ⁴, Hsieh CF⁵, Horng JT⁶(PubMed)
(21) Anti-viral activity of water extract of Paeonia lactiflora pallas against human respiratory syncytial virus in human respiratory tract cell lines by Lin TJ¹, Wang KC, Lin CC, Chiang LC, Chang JS.(PubMed)
(23) Paeoniflorin inhibited the tumor invasion and metastasis in human hepatocellular carcinoma cells by Lu JT, He W, Song SS, Wei W.(PubMed)
(24) Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway by Zhang J¹, Dou W, Zhang E, Sun A, Ding L, Wei X, Chou G, Mani S, Wang Z.(PubMed)
(25) The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats by Tang NY¹, Liu CH, Hsieh CT, Hsieh CL.(PubMed)
(26) Triglyceride accumulation: inhibitory effects of tangzhiqing formula by An Y¹, Liu X, Qian Q, Zhang D, Li Y, Gao X, Zhang Y, Wang T.(PubMed)
(27) Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats by Chen X¹, Liu C, Lu Y, Yang Z, Lv Z, Xu Q, Pan Q, Lu L.(PubMed)
(28) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY¹, Pan JQ, Lv JH.(PubMed)
(29) Wound-healing plants from TCM: in vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes by Wang R¹, Lechtenberg M, Sendker J, Petereit F, Deters A, Hensel A.(PubMed)
(30) Anxiolytic-like effect of paeonol in mice by Mi XJ¹, Chen SW, Wang WJ, Wang R, Zhang YJ, Li WJ, Li YL.(PubMed)
(31) Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption by

Hyunil Ha,¹ Ki-Shuk Shim,¹ Hyosun An,¹ Taesoo Kim,¹ and Jin Yeul Ma(PubMed) 

(32) Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint by Wang ZY¹, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY, Chen JP.(PubMed) 

(33) Bioactivity-guided identification and cell signaling technology to delineate the lactate dehydrogenase A inhibition effects of Spatholobus suberectus on breast cancer by Wang Z¹, Wang D, Han S, Wang N, Mo F, Loo TY, Shen J, Huang H, Chen J.(PubMed) 

(34) A lectin from Spatholobus parviflorus inhibits Aspergillus flavus α-amylase: enzyme kinetics and thermodynamic studies by Tintu I¹, Abhilash J, Dileep KV, Augustine A, Haridas M, Sadasivan C.(PubMed) 

(35) Characterization of total phenolic constituents from the stems of Spatholobus suberectus using LC-DAD-MS(n) and their inhibitory effect on human neutrophil elastase activity by Huang Y¹, Chen L, Feng L, Guo F, Li Y.(PubMed) 

(36) Neuroprotective effects of formononetin against NMDA-induced apoptosis in cortical neurons by Tian Z¹, Liu SB, Wang YC, Li XQ, Zheng LH, Zhao MG.(PubMed) 

(37) Antiplatelet effects of Spatholobus suberectus via inhibition of the glycoprotein IIb/IIIa receptor by Lee BJ¹, Jo IY, Bu Y, Park JW, Maeng S, Kang H, Jang W, Hwang DS, Lee W, Min K, Kim JI, Yoo HH, Lew JH.(PubMed) 

(38) [Clinical observation of treating 62 patients with severe aplastic anemia failing in immunosuppressive therapy by integrative medicine].[Article in Chinese]by Su EY¹, Fang YH, Chen HS.(PubMed) 

(39) Backache and Chinese herbs(traditional Chinese medicine)
(40) Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia by Jingyi W¹, Yasuhiro M, Naoya H, Seok RC, Yoshiharu Y, Nagara T, Fumiko T, Shigeru M, Junji K.(PubMed)
(41) [Clinical and experimental study of Ligusticum wallichii and aspirin in the treatment of transient ischemic attack].[Article in Chinese] by Chen DR.(PubMed)
(42) Ligusticum wallichi (Chuan Xiong)(TCMWiki)
(43)Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta: comparison of a butanolic fraction and tetramethylpyrazine, the main active component of Ligusticum wallichii by Kim EY¹, Kim JH, Rhyu MR.(PubMed)
(44) Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rat by Zhuo Yuan, ¹ Junping Zhang, ^{1 ,*} and Cui Yang(PubMed)
⁽⁴⁵⁾ Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson's disease induced by MPTP by Lu C¹, Zhang J², Shi X³, Miao S¹, Bi L¹, Zhang S⁴, Yang Q¹, Zhou X¹, Zhang M¹, Xie Y¹, Miao Q¹, Wang S¹.(PubMed)
(46) Study on anti-atherosclerotic effect of Suxiao Jiuxin Pill and its mechanism by Guo QX, Zhang J, Li YQ, Zhang GF.(PubMed)
(47) Ligustrazine attenuates elevated levels of indoxyl sulfate, kidney injury molecule-1 and clusterin in rats exposed to cadmium by Lan Z¹, Bi KS¹, Chen XH².(PubMed)
(48) Prevention of inflammation-mediated neurotoxicity by butylidenephthalide and its role in microglial activation by Nam KN¹, Kim KP, Cho KH, Jung WS, Park JM, Cho SY, Park SK, Park TH, Kim YS, Lee EH.(PubMed)
(49) Polyphenols and neuroprotection against ischemia and neurodegeneration by Lin B.(PubMed)
(50) Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats by Zengyong Q¹, Jiangwei M, Huajin L.(PubMed)
(51) Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats by Li N¹, Zhu Y, Deng X, Gao Y, Zhu Y, He M.(PubMed)
(52) Selection of component drug in activating blood flow and removing blood stasis of Chinese herbal medicinal formula for dairy cow mastitis by hemorheological method by Lu Y¹, Hu YL, Kong XF, Wang DY.(PubMed)
(53)The development of nao li shen and its clinical application by Lu SL¹, Liu X, Wang JL, Ying Q, Hu SG, Hu PP, Zhu GP, Zhen HW, Bai YT, Wang Q.(PubMed)
craniocerebral injury), degeneration of spinal disks in the neck (cervical spondylosis) and brain dysfunctions related to disease of the blood vessels (cerebrovascular diseases)
(54) Effects of huoxue injection on the adherence of human monocytes to endothelial cells and expression of vascular cell adhesion molecules].[Article in Chinese]by Zhu LQ¹, Wang SR, Qin Y.(PubMed)
(55) Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models by Buenafe OE¹, Orellana-Paucar A, Maes J, Huang H, Ying X, De Borggraeve W, Crawford AD, Luyten W, Esguerra CV, de Witte P.(PubMed)
(56) Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice by Lam BY¹, Lo AC, Sun X, Luo HW, Chung SK, Sucher NJ.(PubMed)
(57) [Study of xiaozhang recipe combined with lamivudine in treatment of 84 chronic viral hepatitis B patients with compensated liver cirrhosis][Article in Chinese]  by Zhou ZH¹, Li M, Huang LY.(PubMed)
(58) [Effect of lixu jieyu recipe in treating 75 patients with chronic fatigue syndrome].[Article in Chinese]

by Zhang ZX¹, Wu LL, Chen M.(PubMed)

(59) [Clinical observation on ziyin tongbi decoction in treating benign prostatic hyperplasia][Article in Chinese] by Guo J¹, Song CS, Han Q.(PubMed)

 

The best and healthy recipe: Spiced chili nuts and seeds

Posted  By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe contributed by Fresh and Easy Meals by Better Homes and Gardens

Pick your favorite nuts and seed for this snack recipe. Orange juice concentration spiked with piquant spices gives the mixture a burst of favor.

Prep. 10 minutes
Bake 15 minutes
Oven 300 degrees F
Make 16 (1/4 cup) serving

2 tsp. frozen orange juice concentrate thawed.
2 tsp. Worcestershire sauce
1 tsp. garlic powder
1 tsp. ground cumin
1 tsp. chili powder
1/2 tsp. cayenne pepper
1/4 tsp. salt
1/4 tsp. ground allspice
1.4 tsp. onion salt
2 cups unsalted peanuts, hazelnuts, and/or Brazil nuts
1 cup pecan halves
6 tsp. unsalted shelled sunflower seeds
2 tsp. sesame seeds
Non stick cooking tray

In a large bowl, combined orange juice concentrate, Worcestershire sauce, garlic powder, cumin, chili powder, cayenne pepper,salt, allspice, black pepper and onion salt. Stir in nuts and seeds; toss to coat.
Line a 15x10x1 inch baking pan with foil; slightly coat with nonstick cooking spray. Spread nuts and seed on foil. Bake in a300 degrees oven for 15 to 20 minutes or until toasted, stirring once. Cool. Store in an airtight container at room temperature for up to 1 week.

Nutrition facts per serving: 186Cal, 16 g total fat(2 g sat. fat), 0mg cholesterol, 59 sodium, 7 g carbo, 3 g fiber, 6 g pro.
Daily value: 2% vitamin A, 6% vitamin C, 2% calcium, 5% iron.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

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(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system - Free radical causes of dementia (Alzheimer’s disease)

 By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

               Diseases of Central Nervous system

                                 Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
II. Causes of dementia
B. Free radical causes of dementia
B.1. Alzheimer’s disease
1. Free radical and Alzheimer’s disease
Free radicals causes Alzheimer’s disease is well defined in many researches(25)(26). Oxidative stress-induced injury involved the selective modification of different intracellular proteins may lead to the neurofibrillary degeneration of neurons in the brain(27)(28) (source)

2.  Antioxidants and Alzheimer’s disease
a. Docosahexaenoic acid (DHA)
Change of brain aging in DHA metabolism, was found in patients with Alzheimer's disease(29). DHA, a naturally occurring component found in every cell membrane(29) increases phosphatidylserine(30)(31) is important in decreased production of proinflammatory omega-6 eicosanoids causes of Alzheimer's disease(31) and in improved the memory of animals with Alzheimer's disease by suppressing oxidative damage in the brain(32).

b. Vitamin E
Vitamin E, and drugs(memantine) reduced generalized inflammation, may slow the decline of mental and physical abilities in people with Alzheimer's disease (AD) over the long term(33). Also vitamin E inhibits cells damage and cells death caused by beta-amyloid(34)(35), which is toxic to brain cells(36).

c. Phosphatidylserine
Patients who had Alzheimer’s disease took 100 milligrams per day (mg/day) of phosphatidylserine scored significantly better on standardized memory tests at the end of the 12-week trial period than patients without(37)(38).

d. Antioxidants
Antioxidant are found at much lower levels for patients with Alzheimer’s disease(39)(40)(41) , such as serum of vitamin A, C, E, zinc and transfferin.

e. Muscarinic cholinergic receptors 
 Alzheimer’s disease patients showed to exhibit the significant loss of muscarinic cholinergic receptors neurons(42) causes of reduced volume of neural transmission that can lead to loss of memory(43).

f. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

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Lunch box or not: PB&J extreme

Posted By Kyle J. Norton  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe contributed by Yum-O, the family cook book by Rachel Ray, Published by Clarkson Potter, New York.You can view her website at yum-o.org  

Ingredients
2  tablespoon chuncky peanut butter
2 slices whole-wheat bread, toasted
1/2 banana, thinly sliced
Drizzle of honey
Sprinkle of ground cinnamon
2 slices crispy cooked turkey bacon, crumbled

Instructions
Spread the peanut butter on 1 slice of the toast. Arrange the banana slices on top of the peanut butter, drizzle with honey, then sprinkle with  cinnamon. Top with bacon crumble and the second slice of toast. Cut corner to corner to make 4 triangles

Serves 1

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Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

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Women's Health - Premenstrual syndrome(PMS): The Effects of Fatty Acids(Revised edition with references)

By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

 Premenstrual syndrome is defined as faulty function of the ovaries related to the women's menstrual cycle, effected over 70% to 90% of women in the US and lesser for women in Southeast Asia because of difference in living style and social structure. The syndrome also interferes women's physical and emotional states, and daily activities as a result of hormone fluctuation and occurs one to two weeks before menstruation and then declines when the period starts.
I. Types of Fat Acids
1. Mono-unsaturated fats
Mono-unsaturated have only one double bond between 2 carbon atoms in the chemical chain and the rest of the carbon atoms are single-bonded, therefore, mono-unsaturated fatty acids have a higher melting temperature than polyunsaturated fatty acids but lower than saturated fatty acids, liquid at room temperature. Since our body can not produce them, we have to take them regularly.

2. Poly-unsaturated fats
Poly-unsaturated fats contains 2 or more double bonds in the chemical chain. Since it is one hydrogen atom deficits on the molecule's surface, leading to significant lowering melting temperature than other fats. It is also liquid in the room temperature and contains most important essential fatty acids Omega 3 and 6. Since our body can not make them, we have to take them regularly.

3. Saturated fats
Saturated fat contains only saturated fatty acid radicals. Chemically, in saturated fats every member carbon atoms is surrounded by maximum number of hydrogen as a straight chain with all atoms packing together tightly.

4. Trans fats
 By adding hydrogen to the vegetable oils and eliminating some double bond in their chemical structures, to make the oils solid at room temperature, trans fats raise bad cholesterol (LDL) and lower the good cholesterol (HDL) and it can be found everywhere, including margarine, fast foods, vegetable shortening, baked foods, packaged foods and frozen foods.

II. The Effects
A. Liver
 Over consumption of saturated fat reduces function of liver(1) in secreting bile  and interference with liver in regulating function of pancreas in insulin production(1), elevating symptoms of PMS including menstrual cramp and pain(2)(3).

B. Prostaglandins hormones
1. Definition
Prostaglandins are found in most tissues and organs. They are produced by all nucleated cells except lymphocytes. Prostaglandins are generated from
a) Gamma linoneic acid ( GLA)
b) Arachidinic acid (AA)
c) Eicosapentaenoic acid (EPA)

2. How prostaglandins effect women with PMS
a. Gamma linoneic acid ( GLA)
GLA is also known as essential Omega 6 fatty acid, having anti-inflammatory properties found primarily in vegetable oils. It may also be converted from linolenic acid before converting to prostaglandins PGE1(5) with function in regulating the uterine contraction(4). If there are blockage caused abnormal function of fat and protein metabolism, imbalance of essential Omega 3 and 6 fatty acids(4) and nutrients deficiency(6), may induce imbalance of  prostaglandins hormones, to cause over contraction of uterine muscles(4).

b. Arachidinic acid (AA)
Arachidinic acid (AA) is also converted from linoleic acids after converting to dihomogamma-linolenic acid (DGLA).  Arachidinic acid (AA) deficiency or over abundant cause over production of PGE2 in inducing symptoms of PMS including menstrual pain and cramps(9) and reduced blood flow to the uterus(4)(8). Since meats contain high levels of AA(7), reducing intake of such products will help to restore the balance of prostaglandins hormone PG1 and PG2.

c. Eicosapentaenoic acid (EPA)
Omega 3 fatty acid containing eicosapentaenoic acid is also known as also eicosapentaenoic acid converted from Alpha-linolenic acid(10). EPA is vital for the production of good prostaglandins PGE3 in lessening the risk of inflammation(11) and nervous symptoms of PMS(12).

Unbalance of Omega 3 and 6 fatty acids causes unbalance of hormone of members in the prostaglandins and weakens the liver in fatty acids metabolism, leading to increased risk of symptoms of premenstrual syndrome(3)(4)(5).

C. Saturated fat
Saturated fat is fat consisted of triglycerides and contained only saturated fatty acid radicals mainly from animals. It blocks the absorption of nutrients in the digestive system including essential fatty acids and vitamins and minerals(13), leading to unbalance of prostaglandins family and interfering liver in fat and protein metabolism(12), if consumed in large amount. By the way, saturated fat also enhances building up of cholesterol and triglycerides in your blood, causing numbers of disease including heart diseases and stroke(14).

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Back to Obesity's Complications http://kylejnorton.blogspot.ca/p/obesitys-complications.html

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References
(1) Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans. Rosqvist F1, Iggman D2, Kullberg J3, Cedernaes J4, Johansson HE1, Larsson A5, Johansson L6, Ahlström H3, Arner P7, Dahlman I7, Risérus U8 .(PubMed)
(2) The effects of a high-fat, high-cholesterol diet on markers of uterine contractility during parturition in the rat by Elmes MJ1, Tan DS, Cheng Z, Wathes DC, McMullen S.(PubMed)
(3) Reproductive hormones in plasma over the menstrual cycle in primarydysmenorrhea compared with healthy subjects by Liedman R1, Hansson SR, Howe D, Igidbashian S, McLeod A, Russell RJ, Akerlund M.(PubMed)
(4) The effects of prostaglandin E1 and prostaglandin E2 on in vitro myometrial contractility and uterine structure by Chiossi G¹, Costantine MM, Bytautiene E, Kechichian T, Hankins GD, Sbrana E, Saade GR, Longo M.(PubMed)
(5) Physiology and pharmacology of prostaglandins by Konturek SJ, Pawlik W.(PubMed)
(6) Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model by Fan YY¹, Monk JM, Hou TY, Callway E, Vincent L, Weeks B, Yang P, Chapkin RS.(PubMed)
(7) Contribution of meat fat to dietary arachidonic acid by Li D¹, Ng A, Mann NJ, Sinclair AJ.(PubMed)
(8) [Imbalance of blood flow induced by sympathetic block was corrected by prostaglandin E1].[Article in Japanese by Okuda Y¹, Kitajima T.(PubMed)
(9) Clinical use of misoprostol in nonpregnant women: review article by Choksuchat C.(PubMed)
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The best of healthy sauce: Walnut and garlic sauce

Posted By Kyle J. Norton  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe contributed by Yum-O, the family cook book by Rachel Ray, Published by Clarkson Potter, New York.You can view her website at yum-o.org  

For Magret de Canard, This is based on Jeanne Strang's recipe in Goose Fat and Garlic. It is a traditional sauce for duck breast -  a constant favorite in south west France, not a great place to be born a duck! It is very garlicky and quite wonderful. My wife Meredith described it as " mind bogging" on the first tasting it 20 years ago.
75 g/ 3 oz. peeled walnuts- take care that bits of shell don't get included
50g/ 2 oz. garlic cloves - crushed
1 tbsp. chopped parsley
salt and pepper to taste
150 ml/5fl oz./ 1/2 cup walnut oil
Put all the ingredients in a food mixer. Mix to a fairly fine texture. Add a little water if need to.


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(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system - The Deficient Causes of Dementia

 By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

               Diseases of Central Nervous system

                                 Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
II. Causes of dementia
A. Deficient cause of dementia due to aging
1. Vitamin D and 1,25-dihydroxyvitamin D(3) deficiency
Vitamin D levels not only plays a important role in the pathogenesis of many age-associated diseases including cancer, heart disease, type 2 diabetes mellitus and stroke, but  also associats with increased risk of prevalent cognitive dysfunction. According to number of studies, raising vitamin D plays a role in decreased cognitive dysfunction and dementia(a).  Evidence from epidemiological also insisted the association between 25(OH)D concentrations and systolic blood pressure, risk for CV disease-related deaths, symptoms of depression, cognitive deficits, and mortality(b).

2. Folic acid with vitamin B12 deficiency
Folates are vitamins essential to the development of the central nervous system. Deficiency of folate can increase the risk of dementia. According to Cochrane Dementia and Cognitive Improvement Group, folic acid plus vitamin B12 was effective in reducing the serum homocysteine concentrations, with no adverse effects(c).

3. Vitamin B12 deficiency
An association between neuropsychiatric disorders and vitamin B12 deficiency has been recognized since 1849. Deficiency of Vitamin B12 are found in many elder and might contribute to age-associated cognitive impairment, according to the Scientist at Cochrane Dementia and Cognitive Improvement Group(d).

4. Vitamin B6 deficiency
 Vitamin B6 supplementation showed to reduce the risk of developing cognitive impairment by older healthy people, or improving cognitive functioning of people with cognitive decline and dementia, according the study conducted by Cochrane Dementia and Cognitive Improvement Group(e).

5. Deficiency of Insulin-like growth factor (IGF)-1and growth hormones
Deficiency of Insulin-like growth factor (IGF)--1 hormone may contribute to the genesis of cognitive impairment and dementia in the elderly patients. Old age, in the absence of circulating IGF-1, a hormone with a complex role in brain function have linked IGF-1 to an acceleration of neurological diseases(f). Growth hormone and IGF-1 replacement showed to increase neurogenesis, vascular density, and glucose utilization, and alters NMDA receptor subunit composition in brain areas that are implicated in learning and memory, in animal (g)and children(h) studies.

8. Deficiency of cerebrospinal fluid melatonin
 Melatonin plays an essential role to carried in ventricular system via choroid plexus portals. In Alzheimer's disease, inadequate melatonin increases risk of the neuropathological changes due to hydroxyl radicals cause of damage mitochondria and initiated cascade of oxygen radicals(i).

9. Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations
DHEA, a neurosteroid secreted by the adrenal cortex. is also a neurosteroid. The levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrationsare  decline in concentration with age(j).

10. Etc.


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References
(a) http://www.ncbi.nlm.nih.gov/pubmed/21790207
(b) http://www.ncbi.nlm.nih.gov/pubmed/20226390
(c) http://www.ncbi.nlm.nih.gov/pubmed/14584018
(d) http://www.ncbi.nlm.nih.gov/pubmed/12918012
(e) http://www.ncbi.nlm.nih.gov/pubmed/14584010
(f) http://www.ncbi.nlm.nih.gov/pubmed/22503992
(g) http://www.ncbi.nlm.nih.gov/pubmed/16024298
(h) http://www.ncbi.nlm.nih.gov/pubmed/15478038
(i) http://www.ncbi.nlm.nih.gov/pubmed/11461164
(j) http://www.ncbi.nlm.nih.gov/pubmed/19665809