By Kyle J. Norton
Avocado is a commercially
valuable fruit cultivated in tropical climates throughout the
world. it is a green-skinned, pear-shaped fruit that ripens after
harvesting and native to the Caribbean, Mexico, South America and
Central America, belonging to the flowering plant family Lauraceae.
Nutrients
1. Vitamin K
2. Dietary fiber
3. Vitamin B6
4. Vitamin C
5. Folate
6. Copper
7. Potassium
8. Amino acid
9. Others
a) Vitamin A
b) Vitamin B1, B2, B3, B12
c) Vitamin D
d) Vitamin E
e) Carotenoid
f) Pantothenic acid
g) Calcium
h) Chromium
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol (average
76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20%
saturated, and 20% unsaturated); high amounts of glutathione (27.7
mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars
(glucose, fructose, d-mannoheptulose,
a taloheptulose, and an alloheptulose); two bitter substances
(1-acetoxy-2,4-dihydroxyheptadeca-16-ene and
1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins;
persenones A and B(a).
1. Avocado and leukemia
Hass avocados, the most common commercial avocado
cultivars in the world, not only support the cardiovascular health
also process the properties in maintaining healthy weight and healthy aging(1).
Endocarp, seed, whole seed, and leaf (0.1 mg/mL) extracts showed to
inhibit leukemic cell profileration through an oxidative stress
mechanism, according to the University of Antioquia(2)
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) Pro-apoptotic effect of Persea americana var. Hass (avocado) on Jurkat lymphoblastic leukemia cells by Bonilla-Porras AR1, Salazar-Ospina A, Jimenez-Del-Rio M, Pereañez-Jimenez A, Velez-Pardo C.(PubMed)
(3)
2. Avocado and Cholesterol
Cholesterol is needed for our body to build cell walls, make hormones
and vitamin D, and create bile salts that help you digest fat. However
too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place.
Avocado may be one of best fruit used to reduce the accumulation of bad
cholesterol in the blood, as it process body fat lowering capacity. The
fruit was also found to reduced risk of metabolic syndrome(1),
including obesity(2) and cardiovascular diseases(3) According to Dr.
Monika P, and Dr. Geetha A., hydro-alcoholic fruit extract of P.
americana (HAEPA) in a a period of 14 weeks rat study, showed a
significantly decreased body mass index (BMI), total fat pad mass and
adiposity index. Levels of reduced glutathione, adiponectin, mRNA
expression of adiponectin were significant lower in rat in rats fed a
high-fat diet (HFD)(4). The study of the level of expression of
adiponectin and PPAR-γ in rats, Persea americana (avocado)
fruit extract enhanced the HAEPA exhibition of hypolipidemic activity
probably by increasing the mRNA, which is RNA messenger expression of
adiponectin, a protein with function in regulating glucose levels as
well as fatty acid breakdown. and PPAR-γ, a protein with function in
regulation of cellular metabolism (carbohydrate, lipid, protein), and
tumorigenesis,
which reduce the risk of hyperlipidemia and obesity(5). In support of
the view of above, researchers at the Potchefstroom University for
Christian Higher Education, suggested that consumption of 200 g/d of avocado
within an energy-restricted diet does not compromise weight loss when
substituted for 30 g of mixed dietary fat. Serum lipid concentrations,
plasma fibrinogen, arterial compliance, and systolic and diastolic blood
pressures were not affected by weight loss or avocado intake(6).
References
(1) Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008 by Fulgoni VL 3rd1, Dreher M, Davenport AJ.(PubMed)
(2) Effect of Persea americana (avocado)
fruit extract on the level of expression of adiponectin and PPAR-γ in
rats subjected to experimental hyperlipidemia and obesity by Monika P,
Geetha A.(PubMed)
(3) Avocado oil supplementation modifies cardiovascular risk profile
markers in a rat model of sucrose-induced metabolic changes by
Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)
(4) Effect of Persea americana (avocado)
fruit extract on the level of expression of adiponectin and PPAR-γ in
rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(5) Effect of Persea americana (avocado)
fruit extract on the level of expression of adiponectin and PPAR-γ in
rats subjected to experimental hyperlipidemia and obesity by Monika P,
Geetha A.(PubMed)
(6) Substitution of high monounsaturated fatty acid avocado
for mixed dietary fats during an energy-restricted diet: effects on
weight loss, serum lipids, fibrinogen, and vascular function by Pieterse
Z1, Jerling JC, Oosthuizen W, Kruger HS, Hanekom SM, Smuts CM, Schutte AE.(PubMed)
3. Avocado and Diabetes
Diabetes is defined as a condition caused by
insufficient insulin entering the bloodstream to regulate the glucose.
It is either caused by cells in pancreas dying off or receptor sites
clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Extracts of Persea americana Mill (Lauraceae) ("Avocado")
has been used in folk medicine to treat hypertension and lower blood
glucose, but the underlined mechanism is unknown. According to
University of KwaZulu-Natal, in STZ-induced diabetic rats, the avocado extract
may be used in diabetic management through its effectiveness in
increased hepatic glycogen concentrations, decreased urine flow and
electrolyte excretion rates, whilst subchronic treatment reduced plasma
creatinine and urea concentrations(1). Other study suggested that
consuming monounsaturated fatty acids in avocado in the diet of patients
with non-insulin-dependent diabetes mellitus
improves the lipid profile favorably, maintains an adequate glycemic
control, and offers a good management alternative(2) and
high-monounsaturated fat diet metabolited better in some aspects than
the currently recommended diet for non-insulin-dependent diabetes mellitus (NIDDM)(3).
References
(1) Effects of Persea americana Mill (Lauraceae) ["Avocado"]
ethanolic leaf extract on blood glucose and kidney function in
streptozotocin-induced diabetic rats and on kidney cell lines of the
proximal (LLCPK1) and distal tubules (MDBK), by Gondwe M1, Kamadyaapa DR, Tufts MA, Chuturgoon AA, Ojewole JA, Musabayane CT.(PubMed)
(2) Effect of a high-monounsaturated fat diet enriched with avocado in NIDDM patients by Lerman-Garber I1, Ichazo-Cerro S, Zamora-González J, Cardoso-Saldaña G, Posadas-Romero C.(PubMed)
(3) The high-monounsaturated fat diet as a practical alternative for NIDDM by Campbell LV1, Marmot PE, Dyer JA, Borkman M, Storlien LH.(PubMed)
4. Avocado and Cardiovascular disease
Heart diseases
are caused by high blood pressure that contributes to hardening of the
arteries. High levels of bad cholesterol (LDL) building up in the
arteries as a result of uncontrolled diet with high levels of saturated
fat and trans fat.
In animal study, Persea americana Mill
(Lauraceae) aqueous leaf extract (PAE) showed a significant effect in
reduced risk and treatment of heart diseases through its hypotensive
(antihypertensive) effects(1). According to Nutrition Science Solutions
LLC, consumption of one-half an avocado (68 g), not only provided many nutrients for body needed, but also supported cardiovascular health(2).
The National Health and Nutrition Examination Survey (NHANES) 2001-2008, suggested that avocado consumption is associated with improved overall diet quality, nutrient intake, and reduced risk of metabolic syndrome(3), including cardiovascular disease.
References
(1) Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals by Ojewole JA1, Kamadyaapa DR, Gondwe MM, Moodley K, Musabayane CT.(PubMed)
(2) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(3) Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008 by Fulgoni VL 3rd1, Dreher M, Davenport AJ.(PubMed)
5. Avocado and Anti inflammatory effect
The immune system is the
set of cells and their activity against antigens or infectious agents
that comprises of the body's defense system against diseases. The
immune system does a great job of keeping people healthy and preventing
infections. Beside foods and nutritional supplements, herbs also play a
important role in helping the immune system defend against viruses and
bacteria attacks.
In UV-induced damage in skin cells, the unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, showed
to reduce UVB-induced damage and inflammation in skin. Application
of the extract prior to their exposure to UVB enhanced a protective effect,
increased cell viability, decreased the secretion of IL-6,
a pro-inflammatory cytokine and an anti-inflammatory myokine. and PGE(2)
in mediated the inflammation process , and DNA repair(1).
Avocado soybean unsaponifiables (ASU)supplement, when applied alone, exhibited pain-reducing and anti-inflammatory
effects, through suppressing TNF-alpha, a pleiotropic inflammatory
cytokine, IL-1beta which plays a central role in the regulation of
immune and inflammatory responses, COX-2 which involved in the
conversion of arachidonic acid to prostaglandin H2, iNOS gene expression
which involved in immune response, and prostaglandin E2 and nitric
oxide production in articular chondrocytes and monocyte/macrophages(3).
When used combination with epigallocatechin gallate, in the study by
Nutramax Laboratories, Avocado soybean unsaponifiables (ASU)supplement demonstrated a significantly anti-inflammatory activity and may offer an attractive supplement or alternative to non-steroidal anti-inflammatory drugs (NSAIDs) in the management of osteoarthritis(2).
References
(1) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(2) Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate by Heinecke LF1, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG.(PubMed)
(3) Avocado soybean unsaponifiables (ASU)
suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and
prostaglandin E2 and nitric oxide production in articular chondrocytes
and monocyte/macrophages by Au RY1, Al-Talib TK, Au AY, Phan PV, Frondoza CG.(PubMed)
6. Avocado and as Antioxidant
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules
during a chemical reaction. They may have positive, negative or zero
charge. The unpaired electrons cause radicals to be highly chemically
reactive in the human body, leading to aging and cancers.
eEthyl acetate, containing 70% acetone, and 70% methanol extracts of the peel, pulp, and seed from two avocado (Persea americana Mill) exerted its antioxidant activity in vitro against microbial pathogens, including Gram-positive bacteria through inhibition of oxidative
stress(1). the Tecnológico de Monterrey-Campus Monterrey suggested that avocado pulp may sever as a novel lipophilic antioxidants
in a food matrix due to the presence of acetogenins(2), a class of
polyketide natural products found in plants. The University of
California in the study of the effect of harvest date on nutritional
compounds and antioxidant activity (AOC) in avocado (Persea
americana Mill. cv Hass) fruit , suggested that AOC in early harvested
fruit after storage for 35 days was much higher than that in late
harvested fruit after storage for 21 days(3).
References
(1) Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties by Rodríguez-Carpena JG1, Morcuende D, Andrade MJ, Kylli P, Estévez M.(PubMed)
(2) Activity-guided identification of acetogenins as novel lipophilic antioxidants present in avocado pulp (Persea americana) by Rodríguez-Sánchez D1, Silva-Platas C, Rojo RP, García N, Cisneros-Zevallos L, García-Rivas G, Hernández-Brenes C.(PubMed)
(3) Effect of harvest date on the nutritional quality and antioxidant capacity in 'Hass' avocado during storage by Wang M1, Zheng Y, Khuong T, Lovatt CJ.(PubMed)
8. Avocado and osteoarthritis
Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.
Avocado/soybean unsaponifiables (ASU)
supplement, in the searching for randomised, placebo-controlled,
double-blind trials of ASU, suggested that ASU improved the symptoms of
OA, with only real long-term trial yielded a largely negative result,
according to Dr. Ernst E.(1). The Frederiksberg Hospital in the study of
the same, with 664 OA patients with either hip (41.4%) or knee
(58.6%) suggested that the 3 months, Avocado/soybean unsaponifiables (ASU) supported better
chances of success in patients with knee OA than in those with hip
OA(2). Other study also found a significantly effective of the
supplement ASU in reduced the progression of joint space loss as
compared with placebo in the subgroup of patients with advanced joint
space narrowing, but require confirmation in a larger placebo-controlled
study in hip OA(3).
References
(1) Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review by Ernst E.(PubMed)
(2) Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(3) Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip by Lequesne M1, Maheu E, Cadet C, Dreiser RL.(PubMed)
9. Avocado and Prostate Cancer
Intake of dietary MUFA from whole fruit of avocado are associated to
reduced risk of prostate cancer, The new study at the University of the
West Indies suggested(1). In support of the above, the University of
California suggested that the anti prostate cancer effect are not as
result of a single ingredient such as related carotenoids (zeaxanthin,
alpha-carotene, and beta-carotene), lutein but the interaction of all
ingredients in the whole fruit conbination with other det-derived
phytochemicals through cell cycle arrest and G(2)/M cell cycle arrest
accompanied by an increase in p27 protein in controlling the cell cycle
progression at G1 in incubation of PC-3 cells(3). The Purdue University
study in the evaluation of the anti cancers effect of avocado also showed a
positive effect of the whole fruit in inhibition of six human tumor
cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(4).
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1,
Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N,
Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
10. Avocado and Breast cancer
Persin, the toxin chemical compound found in the fruits and leaves of
avocado showed to inhibit human breast cancer cell line, in the testing
of synthetic analogues of the avocado-produced
toxin persin(1). In support to the above, researchers at the Gavan
institution, suggested that persin could be given together with commonly
used breast cancer drugs like tamoxifen, which seem to act in a
different way, but patients would benefit by needing smaller amounts of each
type of medicine. Indeed, in the laboratory, persin and tamoxifen look
to be a good combination(2). Other member of Persea, Persea declinata (Bl.) Kosterm from the same genus with avocado, in the
Lauraceae family and widely distributed in Southeast Asia, in the
testing against MCF-7 Cells showed that its bark methanolic crude
extract (PDM) found to inhibit cell cycle arrest and subsequently induced
apoptosis through increased the expression of the proapoptotic
molecule, Bax(pro-apoptosis), but decreased the expression of
prosurvival proteins, Bcl-2 (pro-apoptotic oranti-apoptotic) and
Bcl-xL(pro- and anti-survival protein) in a dose-dependent manner(3).
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References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG1, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ.(PubMed)
(2) Persin - the avocado toxin that kills breast cancer cells(Gavan Institution)
(3) Persea declinata (Bl.) Kosterm Bark
Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle
Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation by
Narrima P1, Paydar M1, Looi CY1, Wong YL1, Taha H2, Wong WF3, Ali Mohd M1, Hadi AH(PubMed)
11. Avocado and Skin health
In a in growing rats fed diets containing 10% (w/w) of the tested oils,
showed to increased soluble collagen content due to a result of a
consequence of the inhibition of lysyl oxidase activity(1). On wound
healing in rats, after the 14th day of treatment with 50% SSFAO or avocado
oil containing rich source of oleic acid and essential fatty acids,
exhibited a significant increase in percentage wound contraction and
reepithelialisation(2). In Exposing skin to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado,
reduced significantly UV-induced cellular damage, through increasing
cell viability, decreased the secretion of IL-6, a pro-inflammatory
cytokine and an anti-inflammatory myokine. and PGE(2) in mediated the inflammation process(3).
References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1,
Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino
CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
Side effects
1. Skin product of avocado oils may contain
latex which can cause skin side effect in certain people with
hypersensitivity to latex, leading to symptoms of reddening of the skin,
itching, hives, or eczema.
2. Liver damage
Certain types of avocado may cause liver damage as a result of collagen accumulation in the liver
3. Breastfeeding
Some types of Avocado may be unsafe during breastfeeding as it can cause problems of upset stomachs in babies.
4. Drugs
Avocado may decrease the effect of "blood thinning" or anti-inflammatory medications.
5. It may cause symptoms of gastrointestinal irritation, vomiting,
diarrhoea, respiratory distress, congestion, fluid accumulation due to
toxic fatty acid derivative, Persin.
6. Etc.
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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Thursday, 29 May 2014
Food Therapy - Eggplant and cancer
Eggplant is a species of S. melongena, belonging to the family
Solanaceae and native to India. The plant has been cultivated in
southern and eastern Asia since prehistory. It is famous with its
deeply purple and the best eggplant can be found from August through
October when it is in season.
Nutritional Supplements
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Tryptophan
14. Manganese
15. Calcium
16. Copper
17. Iron
18. Magnesium
19. Phosphorus
20. Potassium
21. Zinc
22. Etc.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin and other Polyphenolic compounds.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
The study of antiproliferative activities against human colon (HT29) and liver (HepG2) cancer cells conducted by Yeungnam University, the eggplant glycoalkaloids solamargine showed to inhibit both cancer cell lines but greater in colon cancer cell line(1). In human fibrosarcoma HT-1080 cell, delphinidin, a flavonoid pigment contained in the peel of eggplant, slightly inhibited tumor cell invasiveness probably through slight inhibition of the activity of MMPs(secretes matrix metalloproteinase)(2). According to Dr. Shimada A. in an one year (continuous 2 days for 12 months) food surveys held at 5 areas in Japan, the frequency of intake eggplant may associate to increase risk of gastric cancer and gastric cancer mortality rate(3), but may account partly for the geographic variation in gastric cancer mortality in Japan(4).
Ovarian Cysts And PCOS Elimination
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References
(1) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells by Lee KR1, Kozukue N, Han JS, Park JH, Chang EY, Baek EJ, Chang JS, Friedman M.(PubMed)
(2) Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro by Nagase H1, Sasaki K, Kito H, Haga A, Sato T.(PubMed)
(3) [Regional differences in gastric cancer mortality and eating habits of people].[Article in Japanese] by Shimada A.(PubMed)
(4) Food consumption and gastric cancer mortality in five regions of Japan by Tsubono Y1, Kobayashi M, Tsugane S.(PubMed)
Nutritional Supplements
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Tryptophan
14. Manganese
15. Calcium
16. Copper
17. Iron
18. Magnesium
19. Phosphorus
20. Potassium
21. Zinc
22. Etc.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin and other Polyphenolic compounds.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
The study of antiproliferative activities against human colon (HT29) and liver (HepG2) cancer cells conducted by Yeungnam University, the eggplant glycoalkaloids solamargine showed to inhibit both cancer cell lines but greater in colon cancer cell line(1). In human fibrosarcoma HT-1080 cell, delphinidin, a flavonoid pigment contained in the peel of eggplant, slightly inhibited tumor cell invasiveness probably through slight inhibition of the activity of MMPs(secretes matrix metalloproteinase)(2). According to Dr. Shimada A. in an one year (continuous 2 days for 12 months) food surveys held at 5 areas in Japan, the frequency of intake eggplant may associate to increase risk of gastric cancer and gastric cancer mortality rate(3), but may account partly for the geographic variation in gastric cancer mortality in Japan(4).
Ovarian Cysts And PCOS Elimination
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References
(1) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells by Lee KR1, Kozukue N, Han JS, Park JH, Chang EY, Baek EJ, Chang JS, Friedman M.(PubMed)
(2) Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro by Nagase H1, Sasaki K, Kito H, Haga A, Sato T.(PubMed)
(3) [Regional differences in gastric cancer mortality and eating habits of people].[Article in Japanese] by Shimada A.(PubMed)
(4) Food consumption and gastric cancer mortality in five regions of Japan by Tsubono Y1, Kobayashi M, Tsugane S.(PubMed)
Phytochemical Isothiocyanates as Antioxidants
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge. The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.
In Fuchs endothelial corneal dystrophy (FECD), an oxidative stress disorder, treatment with Sulforaphane, a molecule within the isothiocyanate group, decreased CEC apoptosis by 55% in unstressed group and by 43% in tBHP-treated specimens, through inhibition of oxidative stress(1).
The Universidade Federal de Ouro Preto study also indicated the similar result of sulforaphane in improvement of antioxidant status in the testing of number of cancer cell lines(2). Other study suggested that isothiocyanates (ITCs), found abundantly in cruciferous vegetables, may be effective as a cancer chemopreventive agent through modulation of phase II detoxifying/antioxidant enzyme activities(3).
Ovarian Cysts And PCOS Elimination
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Reference
(1) Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment by Ziaei A1, Schmedt T, Chen Y, Jurkunas UV.(PubMed)
(2) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(3) Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression by Prawan A1, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN.(PubMed)
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge. The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.
In Fuchs endothelial corneal dystrophy (FECD), an oxidative stress disorder, treatment with Sulforaphane, a molecule within the isothiocyanate group, decreased CEC apoptosis by 55% in unstressed group and by 43% in tBHP-treated specimens, through inhibition of oxidative stress(1).
The Universidade Federal de Ouro Preto study also indicated the similar result of sulforaphane in improvement of antioxidant status in the testing of number of cancer cell lines(2). Other study suggested that isothiocyanates (ITCs), found abundantly in cruciferous vegetables, may be effective as a cancer chemopreventive agent through modulation of phase II detoxifying/antioxidant enzyme activities(3).
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Reference
(1) Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment by Ziaei A1, Schmedt T, Chen Y, Jurkunas UV.(PubMed)
(2) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(3) Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression by Prawan A1, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN.(PubMed)
Egg drop soup with Minced Beef and Cilantro
Recipe contributed by 125 Chinese recipes with Bill Jones and Stephen Wong
6oz. lean ground beef
1/2 tsp. salt
2 tsp. soya sauce
1 tpsp. dry sherry or Chinese Shaoxing wine
2 tsp. minced ginger root
3tbsp. cornstarch divided
3 cups chicken stock
2 large eggs beaten
1 cup cilantro leaves, coarsely chopped
salt and fresh ground white pepper to taste
1. Ina small bowl, combine beef, salt, soya sauce, sherry, ginger root and 1tbsp of the cornstarch. Mix well and set aside to marinate for 20 minutes
In a large saucepan or soup pot, bring chicken stock to a boil. Add beef mixture, a little at a time, stirring to loosen the particles; cook for 2 minutes
Dissolve remaining cornstarch in 2tbsp. water; stir mixture into soup. Return to a boil; stirring until soup is slightly thicken. In a slow stream, pour egg into soup, stirring vigorously; cook until eggs are set, about 30 seconds. Stir in cilantro. Season to taste with salt and pepper. Serve immediately.
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6oz. lean ground beef
1/2 tsp. salt
2 tsp. soya sauce
1 tpsp. dry sherry or Chinese Shaoxing wine
2 tsp. minced ginger root
3tbsp. cornstarch divided
3 cups chicken stock
2 large eggs beaten
1 cup cilantro leaves, coarsely chopped
salt and fresh ground white pepper to taste
1. Ina small bowl, combine beef, salt, soya sauce, sherry, ginger root and 1tbsp of the cornstarch. Mix well and set aside to marinate for 20 minutes
In a large saucepan or soup pot, bring chicken stock to a boil. Add beef mixture, a little at a time, stirring to loosen the particles; cook for 2 minutes
Dissolve remaining cornstarch in 2tbsp. water; stir mixture into soup. Return to a boil; stirring until soup is slightly thicken. In a slow stream, pour egg into soup, stirring vigorously; cook until eggs are set, about 30 seconds. Stir in cilantro. Season to taste with salt and pepper. Serve immediately.
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Wednesday, 28 May 2014
Whole Fruit Avocado and Prostate Cancer
Avocado is commercially
valuable fruit cultivated in tropical climates throughout the
world. It is a green-skinned, pear-shaped fruit that ripens after
harvesting and native to the Caribbean, Mexico, South America and
Central America, belonging to the flowering plant family Lauraceae.
Nutrients
1. Vitamin K
2. Dietary fiber
3. Vitamin B6
4. Vitamin C
5. Folate
6. Copper
7. Potassium
8. Amino acid
9. Others
a) Vitamin A
b) Vitamin B1, B2, B3, B12
c) Vitamin D
d) Vitamin E
e) Carotenoid
f) Pantothenic acid
g) Calcium
h) Chromium
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cells growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Intake of dietary MUFAs from whole fruit of avocado is associated to reduce risk of prostate cancer, the new study at the University of the West Indies suggested(1). In support of the above, the University of California indicated that the anti prostate cancer effect are not as result of a single ingredient such as related carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein but the interaction of all ingredients in the whole fruit combination with other det-derived phytochemicals through cell cycle arrest and G(2)/M cell cycle arrest accompanied by an increase in p27 protein in controlling the cell cycle progression at G1 in incubation of PC-3 cells(3). The Purdue University study in the evaluation of the anti cancers effect of avocado showed a positive effect of the whole fruit avocado in inhibition of six human tumor cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(4).
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Side effects
1. Skin product of avocado oils may contain latex which can cause skin side effect in certain people with hypersensitivity to latex, leading to symptoms of reddening of the skin, itching, hives, or eczema.
2. Liver damage
Certain types of avocado may cause liver damage as a result of collagen accumulation in the liver
3. Breastfeeding
Some types of Avocado may be unsafe during breastfeeding as it can cause problems of upset stomachs in babies.
4. Drugs
Avocado may decrease the effect of "blood thinning" or anti-inflammatory medications.
5. It may cause symptoms of gastrointestinal irritation, vomiting, diarrhoea, respiratory distress, congestion, fluid accumulation due to toxic fatty acid derivative, Persin.
6. Etc.
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
Nutrients
1. Vitamin K
2. Dietary fiber
3. Vitamin B6
4. Vitamin C
5. Folate
6. Copper
7. Potassium
8. Amino acid
9. Others
a) Vitamin A
b) Vitamin B1, B2, B3, B12
c) Vitamin D
d) Vitamin E
e) Carotenoid
f) Pantothenic acid
g) Calcium
h) Chromium
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cells growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Intake of dietary MUFAs from whole fruit of avocado is associated to reduce risk of prostate cancer, the new study at the University of the West Indies suggested(1). In support of the above, the University of California indicated that the anti prostate cancer effect are not as result of a single ingredient such as related carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein but the interaction of all ingredients in the whole fruit combination with other det-derived phytochemicals through cell cycle arrest and G(2)/M cell cycle arrest accompanied by an increase in p27 protein in controlling the cell cycle progression at G1 in incubation of PC-3 cells(3). The Purdue University study in the evaluation of the anti cancers effect of avocado showed a positive effect of the whole fruit avocado in inhibition of six human tumor cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(4).
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Side effects
1. Skin product of avocado oils may contain latex which can cause skin side effect in certain people with hypersensitivity to latex, leading to symptoms of reddening of the skin, itching, hives, or eczema.
2. Liver damage
Certain types of avocado may cause liver damage as a result of collagen accumulation in the liver
3. Breastfeeding
Some types of Avocado may be unsafe during breastfeeding as it can cause problems of upset stomachs in babies.
4. Drugs
Avocado may decrease the effect of "blood thinning" or anti-inflammatory medications.
5. It may cause symptoms of gastrointestinal irritation, vomiting, diarrhoea, respiratory distress, congestion, fluid accumulation due to toxic fatty acid derivative, Persin.
6. Etc.
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
Phytochemical Isothiocyanates and Cancers
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Isothiocyanates and cancers
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
In a case-control study conducted in urban Shanghai (from December 2006 to December 2008), ITC consumption from cruciferous vegetables showed a positive effect in reduce risk of pancreatic cancer after adjusting for possible confounding factors such as age, sex, history of diabetes and pancreatitis(1). Thiazolo, the synthesis of a novel class of quinazoline, produced by the reaction of 4,6-dichloro-5-aminopyrimidine with isothiocyanates in presence of 20 mol% KF/alumina, exhibited antiproliferative activity in lung (NCI-H322 and A549), epidermal (A431) and glioblastoma (T98G), HL-60 cell lines at 20 μM. The effect of compound 4a on mitochondrial potential loss in HL-60 cells probably through cleavage of PARP-1 and procaspase-3 inhibition(2).
The study by Campus Morro do Cruzeiro suggested that the phytochemical inhibited the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, human ovarian cancer cells, and have antiinflammatory properties in the treatment of human T-cell leukemia cells(3).
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References
(1) [A case-control study on the association between urinary levels of isothiocyanates and the risk of pancreatic cancer].[Article in Chinese] by Wang J1, Han L, Zhang W, Wang J, Ni Q, Shen M, Gao Y2.(PubMed)
(2) Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines by Singh B1, Guru SK, Kour S, Jain SK, Sharma R, Sharma PR, Singh SK, Bhushan S, Bharate SB, Vishwakarma RA.(PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
Isothiocyanates and cancers
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
In a case-control study conducted in urban Shanghai (from December 2006 to December 2008), ITC consumption from cruciferous vegetables showed a positive effect in reduce risk of pancreatic cancer after adjusting for possible confounding factors such as age, sex, history of diabetes and pancreatitis(1). Thiazolo, the synthesis of a novel class of quinazoline, produced by the reaction of 4,6-dichloro-5-aminopyrimidine with isothiocyanates in presence of 20 mol% KF/alumina, exhibited antiproliferative activity in lung (NCI-H322 and A549), epidermal (A431) and glioblastoma (T98G), HL-60 cell lines at 20 μM. The effect of compound 4a on mitochondrial potential loss in HL-60 cells probably through cleavage of PARP-1 and procaspase-3 inhibition(2).
The study by Campus Morro do Cruzeiro suggested that the phytochemical inhibited the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, human ovarian cancer cells, and have antiinflammatory properties in the treatment of human T-cell leukemia cells(3).
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References
(1) [A case-control study on the association between urinary levels of isothiocyanates and the risk of pancreatic cancer].[Article in Chinese] by Wang J1, Han L, Zhang W, Wang J, Ni Q, Shen M, Gao Y2.(PubMed)
(2) Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines by Singh B1, Guru SK, Kour S, Jain SK, Sharma R, Sharma PR, Singh SK, Bhushan S, Bharate SB, Vishwakarma RA.(PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
Herbal Chamomile and Insomnia
Chamomile is also known as camomile, common name of
many species daisy-like plants in the family Asteraceae. The herb has
been used in traditional medicine as antispasmodic and anti-inflammatory
constituents and to treat menstrual cramps and sleep disorders, reduce
cramping and spastic pain in the bowels, relieve excessive gas and
bloating in the intestine, etc.
Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).
Insomnia is a sign and symptom of sleep disorder and defined as a condition in which a person has a difficulty falling asleep and/or staying asleep or sleep of poor quality that can lead to substantial impairments in the quality of life and functional capacity of an individual. Most adults have experienced insomnia sometimes in their life. According to statistic, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime and women suffer from insomnia more often than men.
Chamomile, is one of most popular herb used for sleep disorders in herbal medicine. According to the Dr. Srivastava JK and research team at the Case Western Reserve University, many different preparations of the herb have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day(1).
In a standardized chamomile extract for chronic primary insomnia study, in adults with chronic primary insomnia, the herb showed a modest benefits of daytime functioning and mixed benefits on sleep diary(2). According to DR. Wheatley D., the anxiolytic or sedative properties of chamomile chamomile, Ylang-Ylang) would appear to improve sleep, but how practical a form of treatment this may be remains to be determined(3).But in the assessing the benefits of chamomile in sleep time (TST), sleep efficiency, sleep latency, wake after sleep onset (WASO), sleep quality, and number of awakenings, researchers at the1University of Michigan, indicated that it may be the modest advantage on daytime functioning, but did not reach statistical significance(4).
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References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA.(PubMed)
(1a) Anxiety disorder(Canadian mental health association)
(1) Chamomile: A herbal medicine of the past with bright future by Srivastava JK1, Shankar E, Gupta S.(PubMed)(2) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT.(PubMed)
(3) Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. by Wheatley D.(PubMed)
(4) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT.(PubMed)
Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).
Insomnia is a sign and symptom of sleep disorder and defined as a condition in which a person has a difficulty falling asleep and/or staying asleep or sleep of poor quality that can lead to substantial impairments in the quality of life and functional capacity of an individual. Most adults have experienced insomnia sometimes in their life. According to statistic, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime and women suffer from insomnia more often than men.
Chamomile, is one of most popular herb used for sleep disorders in herbal medicine. According to the Dr. Srivastava JK and research team at the Case Western Reserve University, many different preparations of the herb have been developed, the most popular of which is in the form of herbal tea consumed more than one million cups per day(1).
In a standardized chamomile extract for chronic primary insomnia study, in adults with chronic primary insomnia, the herb showed a modest benefits of daytime functioning and mixed benefits on sleep diary(2). According to DR. Wheatley D., the anxiolytic or sedative properties of chamomile chamomile, Ylang-Ylang) would appear to improve sleep, but how practical a form of treatment this may be remains to be determined(3).But in the assessing the benefits of chamomile in sleep time (TST), sleep efficiency, sleep latency, wake after sleep onset (WASO), sleep quality, and number of awakenings, researchers at the1University of Michigan, indicated that it may be the modest advantage on daytime functioning, but did not reach statistical significance(4).
Ovarian Cysts And PCOS Elimination
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References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA.(PubMed)
(1a) Anxiety disorder(Canadian mental health association)
(1) Chamomile: A herbal medicine of the past with bright future by Srivastava JK1, Shankar E, Gupta S.(PubMed)(2) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT.(PubMed)
(3) Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. by Wheatley D.(PubMed)
(4) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT.(PubMed)
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