Wednesday, 9 April 2014
Asthma in Herbs' points of view
Kyle J. Norton
Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc.
Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. According to American academy, allergy, asthma and immunology, about 1 in 10 children (10%) had asthma and 1 in 12 adults (8%) had asthma in 2009. (about 25 million, or 8% of the U.S. population)(1).
Epidemiological studies, linking herbs in reduced risk and treatment have been inconclusive(a)(b)(c)(d), but certain herbs have been found to be effectively in some studies.
1. Angelica sinensis (Oliv.)
Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine as an antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia and high blood pressure. It has analgesic, anti-inflammatory, etc.. Ethanolic extract (AD of Angelica in the study at Korea Institute of Oriental Medicine, showed to suppress airway allergic inflammation, by significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E in mice(1). Danggui Buxue Tang, a composition of Angelica sinensis (AS) and Astragalus membranaceus (AM), in OVA-sensitized mice, its DBT2 or DBT3 showed no improved effects relative to DBT1 in treating asthmatic symptoms but DBT1 showed to suppress airway hyperresponsiveness and OVA-immunoglobulin E (IgE) in serum(2). According to Thammasat University, ethanol found in of Angelica sinensis exerted its anti-inflammatory activity through antioxidant effects(3).
2. Ginkgo biloba
Ginkgo biloba is oldest living tree species, genus Ginkgo, belonging to the family Ginkgoaceae, native to China, from temperate zone to subtropical zone and some parts of north America. It Has been used in traditional herbal medicine in treating impotence, memory loss, respiratory diseases, circulatory disorders and deafness as well as preventing drunkenness, and bedwetting.
Ginkgolide B (GKB), a major chemical compound of ginkgo biloba, in BALB/c mice exerted its anti asthmatic activity through inhibited the increase of T-helper 2 cytokines, such as interleukin (IL)-5 and IL-13 in bronchoalveolar lavage fluid (BALF) and decreased eosinophil count via inhibition of the ERK/MAPK signaling pathway(4). The composition of Ginkgo biloba leaf extract (EGb761), astaxanthin (ASX) and vitamin C, also showed to exhibit the inhibition of asthma-associated inflammation in asthmatic guinea-pigs(5) and Ginkgo biloba extracts showed to inhibit asthmatic disorder through suppression tof NF-kappaB gene expression actively in HL-60 cells(6). Accordiong to Dokuz Eylul University Hospital, biloba alleviates all established chronic histological changes of lung except smooth muscle thickness in a mouse model of asthma(7).
3. Licorice
Licorice (Glycyrrhiza Glabra) also known as sweetwood, is the genus Glycyrrhiza, belonging to the family Fabaceae, native to the Mediterranean and certain areas of Asia. The herb has been used in traditional medicine to treat skin diseases, coughs, constipation, bronchitis, inflammation, arthritis, etc. Licochalcone A (Lico A) isolated from the root of Xinjiang liquorice, exerted its anti-inflammatory activity on a non-infectious mouse model of asthma, through inhibition of the increase in T-helper type 2 cytokines and reduced serum levels of OVA-specific IgE and IgG(8). ASHMI, the composition of aqueous extracts of Lingzhi (Ganoderma lucidum), Kushen (Sophora flavescens) and Gancao (Glycyrrhiza uralensis), showed to be effective on allergic asthma, through inhibition of production of interleukin (IL)-4 and IL-5 by murine memory Th2 cells and eotaxin-1 production by HLF-1 cells(9).
Other study in a murine model also suggested that ASHMI not only significantly reduce eosinophilic pulmonary inflammation, serum IgE levels, IL-4 and IL-13 levels, but also increase IFN-γ production in lung cell cultures in response to antigen stimulation(10).
4. Chamomile
Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc. Water composition extract of a mixture of eight herbs (chamomile, saffron, anise, fennel, caraway, licorice, cardomom and black seed), showed to alleviate the symptoms of asthma, through inhibition of histamine released from chemically- and immunologically-induced cells(11).
5. Garlic
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
Diallyl disulfide (DADS), a major organosulfur compound found in garlic, in an ovalbumin-induced model of allergic asthma and RAW264.7 cells, showed to inhibit the proinflammatory proteins, through up regulation of Nrf-2/HO-1 and down regulation of NF-κB pathways(12). According to the study by Tarbiat Modares University, purified aged garlic extract exhibited the protective effect of asthma through a significant decrease in the hallmark criteria of allergic airway inflammation levels(13).
6. Grape seed extract
Grapefruit seed extract (GSE) is a liquid extracted from the seeds, pulp, and white membranes of grapefruit. The herb has been used in traditional medicine as an anti bacterial, viral, fungal, parasites and to enhance immune system, protect against colds and flu and malignant disease. Grape seed extract (GSPE) may alleviate the symptoms od asthma through its antioxidant activities. According to the study of University of Ulsan College of Medicine, GSPE effectively suppressed inflammation in both acute and chronic mouse models of asthma, through reduced airway hyperresponsiveness (AHR), decreased inflammatory cells in the BAL fluid, reduced lung inflammation and and decreased IL-4, IL-5, IL-13, and eotaxin-1 expression(14) by downregulating the iNOS expression(15). Other study suggested that GSE significantly ameliorated of the pathological changes of ovalbumin-induced asthma, through inhibition of altered the lung parenchyma pathology and inflammation in ovalbumin-induced murine asthma model(16).
7. Green Tea
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
According to teh study at State University of New York Downstate Medical Center, green tea extract (GTE), and its major catechin, consisted an immunoregulatory effects through suppression of IgE production by peripheral blood mononuclear cells of allergic asthmatic patinets(17) and B cell production of IgE without inducing apoptosis(18). Other study suggested an anti asthmatic effect of aqueous extract of Camellia sinensis through increasing the expression level of tumor necrosis factor-beta and interferon-gamma and decreasing the expression of anti-asthmatic cytokines in the lung(19).
8. Ephedra sinica
Ephedra prepared from Ephedra sinica has been used in traditional Chinese medicine for 5,000 years to treat asthma, hypotension and fatigue, etc. In testing the effect of Ma huang water decoction, EWD and cough tablets containing ephedra and liquorice, MXCT, with theophylline (one of the most popular antiasthmatic drugs and a typical substrate of cytochrome P450 (CYP) 1A2, a enzyme in metabolism of xenobiotics), in rat, found the effectiveness of EWD or MXCT in pretreatment in induced CYP1A2 activity, thus speeding up the metabolism of theophylline(20). Modified Shegan Mahuang Decoction (SGMH), in the study of a total of 154 children with cough and variant asthma (C&VA), exhibited the regulation of the serum levels of TNF-alpha (in the regulation of immune cells with function involved in induced fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells), IL-10( an anti-inflammatory cytokine) and IL-13(associated primarily with the induction of airway disease, and anti-inflammatory properties)(21), Other compositions of Herba Ephedrae decoction showed a strong effect in antianaphylaxis asthma(22).
9. Stinging nettle (Urtica dioica)
Sting Nettle is a flower plant in the genus Urtica, belonging tothe family Urticaceae, native to Europe, Africa, Asia, and North America.The herb has been used in traditional medicine as diuretic and laxative agent and to treat diarrhea and urinary disorders, to relieve pain, treat arthritis, asthma, bronchitis, sinusitis, etc. According to the Penn State University College of Medicine, extracts from the stinging nettle may provide therapeutic value for some inflammatory medical conditions, due to its released chemicals act to cause itching, dermatitis, and urticaria within moments of contact(23).
10. Boswellia
B. serrata gum resin extract (BSE) may be potential for the treatment of a variety of inflammatory diseases including inflammatory bowel disease, rheumatoid arthritis, osteoarthritis and asthma, according to Central Laboratory of German Pharmacists, Eschborn,(24), same as boswellic acids in some autoimmune diseases including rheumatoid arthritis, Crohn's disease, ulcerative colitis and bronchial asthma, according to University of Tuebingen(25). The compositions of Boswellia serrata, licorice root (Glycyrrhiza glabra) and Tumeric root (Curcuma longa), in a total of 63 patients with bronchial asthma study, significantly decreased the plasma levels of Plasma leukotriene C(4) (LTC(4))(,) nitric oxide (NO) and malondialdehyde (MDA) in target therapy group when compared with placebo group(26).
11. kava kava (Piper)
Kava Kava is a tall shrub, genus Piper, belonging to family Piperaceae, native to western Pacific. The herb has been used in traditional medicine as a drink for sedative and anesthetic effects and to treat anxiety, insomnia, etc.
Kava kava (Piper) one most commonly used as complementary and alternative medicine (CAM) for treatment of asthma, allergy, and immunologic conditions, may display some adverse effects in the form of a hypersensitivity reaction(27). According to University of Aberdeen, kavain and flavokavains A and B treatment in asthmatic subjects enhanced anti-inflammatory mechanisms, through inhibition of both inhibitor of kappaB (IkappaB) degradation and subsequent translocation of p50 and p65 NF-kappaB subunits from the cytoplasm to the nucleus(28).
12. peppermint oil and leaf (Mentha)
Peppermint is a hybrid mint with small purple or white flowers and downy leaves, in the genus Mentha, belonging to the family Lamiaceae, native to to Europe. The herb has been used in folk medicine as analgesic, antiseptic, antispasmodic, decongestant, agent and to relieve gas, nausea, and stomach pain due to an irritable bowel, intestinal cramps, or indigestion, infecttion, etc.
Mentha, a major chemical constituent found in peppermint, its haplocalyx ethanol extract (MH), showed to inhibit inflammation of the airway in an asthmatic model, through inhibited increases in immunoglobulin (Ig) E and T-helper 2 (Th2)-type cytokines such as IL-4 and IL-5 in bronchoalveolar lavage fluid (BALF) and lung tissue(29).
13. Ginseng (Panax)
Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root).
According to Gachon University, Korean. red ginseng (KRG) was found effectively in treating nasal allergic inflammatory reaction in an allergic murine model by reducing Th2 cytokines(30). RG-II, isolated from Panax ginseng, inhibited asthmatic reaction of an ovalbumin-induced murine model, through regulated the T(H)1/T(H)2 immune response(31). Other researchers suggested that Panax ginseng ameliorates airway inflammation through inhibited the numbers of goblet cells and further small G proteins and increased MAP kinases in bronchoalveolar lavage cells and lung tissues, in ovalbumin-induced allergic asthma in mice(32)
14. The compositions
14.1. Sho-seiryu-to (Xiao-Qing-Long-Tang)
Sho-seiryu-to (Xiao-Qing-Long-Tang) is a herbal composition included Chi Fu Ling, Gui Zhi, Bai Shao, Gan Jiang, Gan Cao, Zhi Ban Xia and Wu Wei Zi. According to the China Medical University, Xiao-Qing-Long-Tang (XQLT), inhibited the allergic inflammation including AHR, IgE elevation and eosinophil infiltration in Der p stimulated mice through regulating neurotrophin and reducing TARC(33) and also exhibited anti-airway inflammatory, anti-airway remodeling, and specific immunoregulatory effects in a chronic asthmatic mice model, through downregulated IL-10, IL-13, RANTES, Eotaxin, and MCP-1 mRNA expression in the lung(34). In the comparison of oral administration of 3 mg/day Shoseiryuto, 30 mg/day LFK, 3 mg/day of Shoseiryuto co-administered with 30 mg/day of LFK, and saline showed a significant reduction in the accumulation of eosinophils at 3 mg/day Shoseiryuto co-administered with 30 mg/day of LFK(35).
14.2. Ma-Xing-Gan-Shi-Tang (MXGST)
Ma-Xing-Gan-Shi-Tang (MXGST) is a Chinese herbal formula, included Ephedra, Apricot seed, R.Gypsum and Licorice frequently used in traditional Chinese medicine for asthmatic children in nationwide clinical database in Taiwan(36). According to the Institute of Chinese Medical Science, China Medical, College, Taichung, Taiwan, in actively sensitized guinea pig study, administration of MXGST (10 g/kg) extracts significantly inhibited the antigen induced immediate asthmatic responses(IAR), through stimulation of beta2-adrenoceptors on bronchial smooth muscle and its anti-inflammatory ability to inhibit the neutrophil into the airway(37).
Taken altogether, herbal medicine list above may be effective in prevention and treatment of asthma disorder, through reduction of air way inflammation via inhibition of histamine released from chemically- and immunologically-induced cells, etc. Some researchers suggested that large sample size and muticenter studies are necessary with identification of the active principle in order to improve the validation of the clinical trial. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
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References
(1) Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1 by Lee MY1, Seo CS, Lee JA, Lee NH, Kim JH, Ha H, Zheng MS, Son JK, Shin HK.(PubMed)
(2) Danggui Buxue Tang attenuates eosinophil infiltration and airway hyperresponsiveness in asthmatic mice by Lin CC1, Liou CJ, Chiang CY, Huang WY, Huang WC.(PubMed)
(3) Antioxidant and nitric oxide inhibition activities of Thai medicinal plants by Makchuchit S1, Itharat A, Tewtrakul S.(PubMed)
(4) A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway by Chu X1, Ci X, He J, Wei M, Yang X, Cao Q, Li H, Guan S, Deng Y, Pang D, Deng X.(PubMed)
(5) Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen by Haines DD1, Varga B, Bak I, Juhasz B, Mahmoud FF, Kalantari H, Gesztelyi R, Lekli I, Czompa A, Tosaki A(PubMed)
(6) [Studies on the effect of Ginkgo biloba extracts on NF-kappaB pathway].[Article in Chinese] by Li GH1, Lei XX, Yi YM, Xu BL, Wang HP, Du J.(PubMed)
(7) Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma by Babayigit A1, Olmez D, Karaman O, Ozogul C, Yilmaz O, Kivcak B, Erbil G, Uzuner N.(PubMed)
(8) Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A by Chu X1, Jiang L, Wei M, Yang X, Guan M, Xie X, Wei J, Liu D, Wang D.(PubMed)
(9) Constituents of the anti-asthma herbal formula ASHMI(TM) synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells, and eotaxin by human lung fibroblasts in vitro by Jayaprakasam B1, Yang N, Wen MC, Wang R, Goldfarb J, Sampson H, Li XM.(PubMed)
(10) Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo by Yang N1, Patil S, Zhuge J, Wen MC, Bolleddula J, Doddaga S, Goldfarb J, Sampson HA, Li XM.(PubMed)
(11) The effect of a herbal water-extract on histamine release from mast cells and on allergic asthma by Haggag EG1, Abou-Moustafa MA, Boucher W, Theoharides TC.(PubMed)
(12) Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression by Shin IS1, Hong J, Jeon CM, Shin NR, Kwon OK, Kim HS, Kim JC, Oh SR, Ahn KS.(PubMed)
(13) Purified aged garlic extract modulates allergic airway inflammation in BALB/c mice by Zare A1, Farzaneh P, Pourpak Z, Zahedi F, Moin M, Shahabi S, Hassan ZM.(PubMed)
(14) Grape seed proanthocyanidin extract attenuates allergic inflammation in murine models of asthma by Lee T1, Kwon HS, Bang BR, Lee YS, Park MY, Moon KA, Kim TB, Lee KY, Moon HB, Cho YS.(PubMed)
(15) Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase by Zhou DY1, Du Q, Li RR, Huang M, Zhang Q, Wei GZ.(PubMed)
(16) Grape seed extract attenuates lung parenchyma pathology in ovalbumin-induced mouse asthma model: an ultrastructural study by Mahmoud YI.(PubMed)
(17) Green tea (Camelia sinensis) mediated suppression of IgE production by peripheral blood mononuclear cells of allergic asthmatic humans by Wu SY1, Silverberg JI, Joks R, Durkin HG, Smith-Norowitz TA.(PubMed)
(18) Green tea (Camelia sinensis) suppresses B cell production of IgE without inducing apoptosis by Hassanain E1, Silverberg JI, Norowitz KB, Chice S, Bluth MH, Brody N, Joks R, Durkin HG, Smith-Norowitz TA.(PubMed)
(19) An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers by Heo JC1, Rho JR, Kim TH, Kim SY, Lee SH.(PubMed)
(20) Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats by Tang J1, Zhou X, Ji H, Zhu D, Wu L.(PubMed)
(21) [Effect of modified shegan mahuang decoction on cytokines in children patients with cough and variant asthma].[Article in Chinese]by Chen ZX1, Hu GH.(PubMed)
(22)[Effects of among compositions of Herba Ephedrae decoction on genic xpression of 5-lipoxygenase activating protein, IL-4 and leukotriene C4 in asthmatic mice].[Article in Chinese]by Liu YG1, Luo JB.(PubMed)
(23) Stinging nettle dermatitis by Anderson BE1, Miller CJ, Adams DR(PubMed)
(24) Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data by Abdel-Tawab M1, Werz O, Schubert-Zsilavecz M.(PubMed)
(25) Boswellic acids in chronic inflammatory diseases by Ammon HP.(PubMed)
(26) Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma by Houssen ME1, Ragab A, Mesbah A, El-Samanoudy AZ, Othman G, Moustafa AF, Badria FA.(PubMed)
(27) Complementary and alternative interventions in asthma, allergy, and immunology by Bielory L.(PubMed)
(28) Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives by Folmer F1, Blasius R, Morceau F, Tabudravu J, Dicato M, Jaspars M, Diederich M.(PubMed)
(29) Protective effects of Mentha haplocalyx ethanol extract (MH) in a mouse model of allergic asthma by Lee MY1, Lee JA, Seo CS, Ha H, Lee NH, Shin HK.(PubMed)
(30) The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis by Jung JH1, Kang IG, Kim DY, Hwang YJ, Kim ST.(PubMed)
(31) RG-II from Panax ginseng C.A. Meyer suppresses asthmatic reaction by Jung ID1, Kim HY, Park JW, Lee CM, Noh KT, Kang HK, Heo DR, Lee SJ, Son KH, Park HJ, Shin SJ, Park JH, Ryu SW, Park YM.(PubMed)
(32) Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model by Kim DY1, Yang WM.(PubMed)
(33) Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation by Chang RS1, Wang SD, Wang YC, Lin LJ, Kao ST, Wang JY.(PubMed)
(34) Xiao-Qing-Long-Tang attenuates allergic airway inflammation and remodeling in repetitive Dermatogoides pteronyssinus challenged chronic asthmatic mice model by Wang SD1, Lin LJ, Chen CL, Lee SC, Lin CC, Wang JY, Kao ST.(PubMed)
(35) Enhancement of anti-allergic effects mediated by the Kampo medicine Shoseiryuto (Xiao-Qing-Long-Tang in Chinese) with lysed Enterococcus faecalis FK-23 in mice by Shimada T1, Kondoh M, Motonaga C, Kitamura Y, Cheng L, Shi H, Enomoto T, Tsuruta D, Ishii M, Kobayashi H.(PubMed)
(36) Identifying core herbal treatments for children with asthma: implication from a chinese herbal medicine database in Taiwan by Chen HY1, Lin YH, Thien PF, Chang SC, Chen YC, Lo SS, Yang SH, Chen JL.(PubMed)
(37) The effects of Ma-Xing-Gan-Shi-Tang on respiratory resistance and airway leukocyte infiltration in asthmatic guinea pigs by Kao ST1, Yeh TJ, Hsieh CC, Shiau HB, Yeh FT, Lin JG.
(PubMed)
Food therapy - Celery and Colon Cancer
Celery is a species of Apium graveolens, belonging to the family Apiaceae.
It is cultivated all around the globe as a vegetable. Celery can grow
to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape
joined at a common base.
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Celery and Colon Cancer
Colon cancer is relatively very common and slowly growing and progress cancer and in predictable way and is the third most commonly diagnosed cancer in developed countries, including US and Canada.
Luteolin is 3',4',5,7-tetrahydroxyflavone found abundantly in celery showed in regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line, through inhibited CDK2, decreased levels of Cyclin D1 levels and promoted G2/M arrest via certain mechanisms(b)(c). In the study of a total of 336 incident cases of histologically confirmed colorectal cancer (111 colon cancer and 225 rectal cancer in Harbin city, the Harbin Medical College found that increased consumption of green vegetables, including celery, have a strong protective effect against colorectal cancer(d).
According to Dr. Belanger JT, Perillyl alcohol,a monoterpene isolated from the essential oils of celery seeds was active in inducing apoptosis in tumor cells without affecting normal cells and can revert tumor cells back to a differentiated state, including colon cancer cells(e).
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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin by Lim do Y1, Jeong Y, Tyner AL, Park JH.(PubMed)
(c) Carotenoids and colon cancer by Slattery ML1, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD.(PubMed)
(d) Diet and cancer of the colon and rectum: a case-control study in China by Hu JF1, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ.(PubMed)
(e) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Celery and Colon Cancer
Colon cancer is relatively very common and slowly growing and progress cancer and in predictable way and is the third most commonly diagnosed cancer in developed countries, including US and Canada.
Luteolin is 3',4',5,7-tetrahydroxyflavone found abundantly in celery showed in regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line, through inhibited CDK2, decreased levels of Cyclin D1 levels and promoted G2/M arrest via certain mechanisms(b)(c). In the study of a total of 336 incident cases of histologically confirmed colorectal cancer (111 colon cancer and 225 rectal cancer in Harbin city, the Harbin Medical College found that increased consumption of green vegetables, including celery, have a strong protective effect against colorectal cancer(d).
According to Dr. Belanger JT, Perillyl alcohol,a monoterpene isolated from the essential oils of celery seeds was active in inducing apoptosis in tumor cells without affecting normal cells and can revert tumor cells back to a differentiated state, including colon cancer cells(e).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin by Lim do Y1, Jeong Y, Tyner AL, Park JH.(PubMed)
(c) Carotenoids and colon cancer by Slattery ML1, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD.(PubMed)
(d) Diet and cancer of the colon and rectum: a case-control study in China by Hu JF1, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ.(PubMed)
(e) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
Tuesday, 8 April 2014
Retinitis pigmentosa in Herbs, Foods and antioxidants Points of View
By Kyle J. Norton
Retinitis pigmentosa is a genetic degenerative of eye diseases characteristic of slowly progressive damage of the retina, affecting about 1 in 4,000 people in the United States(1) and about 1in 3500 Canadians.(2).
Epidemiological studies, linking certain herbs, foods and vitamins in delay and alleviation of symptoms of the disease have produced certain success, but large sample size and multi centers studies are necessary to improve the validation of the claims.
A. The herbs
Limitation of research in finding the natural treatment for Retinitis pigmentosa, may be due to its genetically mutative nature.
Bilberry is low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to
the temperate and subarctic regions of the world(3). The herb has been used in folk medicine for its astringent action, an antihistamine effect, and it is also believe to posses anti-microbial as well as anti-diarrheal effects(4), due to its antioxidants effects of delphinidin, cyanidin, petunidin, peonidin, malvidin, etc.(5). According to epidemiological studies. although with limitation, bilberry may be beneficiary in delayed progression and alleviated symptoms of Retinitis pigmentosa due to its effectiveness in protection of vision against many forms of eye diseases.(6)(7)(8)(9). According to 1Johns Hopkins University, in Ninety-six Retinitis pigmentosa (RP) patients with any level of vision completed an anonymous internet survey. bilberry supplement was used in 32% of the correspondents, who were experiencing some impact on vision and physical/emotional well-being(10). In a blue light, a high-energy or short-wavelength visible light induced retinal diseases such as age-related macular degeneration and genetic related retinitis pigmentosa, bilberry extract (B-ext), containing high amounts of polyphenols (anthocyanins, resveratrol, and proanthocyanidins) exhibited its effects in improved the viability of 661 W cells and inhibited the generation of intracellular ROS induced by blue LED light irradiation, probably through inhibited the activation of p38 MAPK and NF-kappaB and caspase-3/7 activation and autophagy(11). Other herbs may also contain similar effects as bilberry such as lingo berry or cowberry(11).
B. The foods
1. The fatty fish and fish oil
Linseed oil or fish oil may have a potential in delay the progression in genetic eye disorder of Retinitis pigmentosa, In retinas of RP rat model, the combination of linseed and fish oil exhibited lower-than-normal levels of ROS DHA may reflect an adaptive, possibly protective, mechanism in the P23H(12). In the University of Ottawa study, Onega 3 fatty acid found abundantly in fish oil showed in improvement of some retinitis pigmentosa outcomes in Clinical preliminary research in this field, further studies are necessary(13). Docosahexaenoic acid (DHA), an other chemical derived from Omega 3 fatty acid, found abundantly in cold water fatty fish, such as salmon, in the study by the Harvard Medical School, showed a positive effect in among patients who were not taking vitamin A prior to entry, those in the DHA + A group had a slower decline in field sensitivity and electroretinogram amplitude than those in the control + A group over the first 2 years(14). Due to the influences of membrane phospholipid fatty acid abnormalities(15), some researchers suggested Fatty acid content alterations in membrane phospholipids of red blood cells of patients with Retinitis pigmentosa may be considered as markers for abnormalities in the lipid metabolism which disturb the retina integrity(16). Unfortunately, according to Johns Hopkins Bloomberg School of Public Health, in the review of the existent data of 394 titles and abstracts and nine ClinicalTrials.gov records and included three RCTs that met eligibility criteria, indicated a no clear evidence for benefit of treatment with DHA for people with RP(13).
2. The coffee
Chlorogenic acid, found in green coffee extract or Coffee, in this prospective, non-comparative, single-arm study, showed a beneficial effect on the peripheral area at the margins of retinal degeneration, and should be considered as an anti-oxidant for the management of retinitis pigmentosa(17)
C. The antioxidants
Antioxidants, may be potential in delay the progression and management of retinitis pigmentosa, according to aster University, when initial signs of vision health deterioration are observed, the appropriate nutritional supplement products may be recommended but only to augment the primary medical treatments(18). Dr. Baumgartner WA and Dr. Baumgartner AM. in one patient study to test a developed and tested a treatment regimen with a range of antioxidants in combination with the off-label use of deprenyl (1 mg/day), a safe antiapoptotic agent, for 140 months indicated a significant improvement as patient's right eye visual field showed 0% decline and left eye 13.3% decline of which defianted to the rate constants for logarithmic decline of visual field measured prior to treatment as visual fields would have decreased by 64% and 70%, respectively by month 140 in the absence of treatment(19).
1. Vitamin A
Vitamin A is a general term of Vitamin A Retinol, retinal, beta-carotene, alpha-carotene, gamma-carotene, and beta-cryptoxanthin best known for its functions for vision health and antioxidant scavenger and essential for growth and differentiation of a number of cells and tissues.
Recommended intakes of vitamin A, according to the Institute of Medicine of the National Academies (formerly National Academy of Sciences) is 600 µg daily as extremely high doses (>9000 mg) can be toxicity as causes of dry, scaly skin, fatigue, nausea, loss of appetite, bone and joint pains, headaches, etc.
Suggestion of the pathology of 11-cis-retinal deficiency caused by gene mutations may result in human retinal diseases that cause blindness, such as Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP)(20) due to involvement in the interaction of light with rhodopsin rather than with free chromophore or bleached rhodopsin(21). In autosomal dominant retinitis pigmentosa patients, vitamin A supplements may be beneficiary for some patients with retinitis pigmentosa, especiallt in patients with autosomal dominant, according to Dr. Roberts L and research team(22). In the regard of Vitamin A's effectiveness in delaying progression of the disease, researchers at the 1Centro di Ricerca in Nutrizione suggested " a lifetime generous supplementation of retinol is advisable, together with a vitamin A-rich diet and/or a dietary supplement (e.g. carrot flour) or pharmacologic supplement of vitamin A. Supply of vitamin A in doses up to 25000 IU (7500 igr/day), even for several years, has so far proved safe from risk of occurrence of liver disease"(23). Although it is controversial, some researchers suggested 15,000 IU of vitamin A palmitate per day may slow the progression, Low vision rehabilitation, long wavelength pass filters, and pedigree counseling remain the mainstay of management(24).
2. Vitamin E
Vitamin E, a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(2), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..
Vitamin E supplementation may improve symptoms and prevent the progression of Retinitis pigmentosa as its variant alpha-tocopherol (vitamin E) inhibited proliferation of human RPE in culture without exerting cytotoxic effects.(25). According to the National University of Mexico, in the study of the formula taurine/diltiazem/vitamin E on the progression of visual field loss in retinitis pigmentosa indicated a improving changes in the, slope values with decreasing the rate of visual field loss, likely through a protective action from free radical reactions in affected photoreceptors(26). Unfortunately, the study of supplements of vitamin A or vitamin E alone or in combination in the affect of the course of retinitis pigmentosa, suggested a positive effect in delay and progress of the diseases with 15,000 IU/d of vitamin A but an adverse effect of 400 IU/d of vitamin E on the course of retinitis pigmentosa(27) and vitamin E should be avoided(28).
3. Lutein
Lutien a xanthophyll, belonging to the family of carotenoids, found abundantly in green leafy vegetables such as spinach, kale, yellow carrots, etc., plays an important role in modulation of light energy and protection of retina against damage of free radicals produced by blue light. Lutein supplementation may be effective in slowing visual function decline in patients with retinitis pigmentosa receiving vitamin A, according to the Harvard Medical School, dietary intake of Lutein supplementation of 12 mg/d slowed loss of midperipheral visual field on average among nonsmoking adults with retinitis pigmentosa taking vitamin A(29). The randomized double-masked placebo-controlled clinical trial [NCT00029289] conducted by the Johns Hopkins University, suggested that lutein supplementation improves visual field and also might improve visual acuity slightly, although these results should be interpreted cautiously(30). The study at the University of Pennsylvania showed no change no in central vision after 6 months of lutein supplementation, but suggested that a long-term influences on the natural history of these retinal degenerations require further study(31).
Other study also showed the potential effect in the combination application of Lutein and vitamin A in patient of Retinitis pigmentosa, as lutein improved short-term vision improvements in age-related macular degeneration--also occur in RP, especially in blue-eyed individuals; vitamin A may also increase visual field benefits(32).
Taken altogether, excluding vitamin E, even with limitation of data, herbal bilberry, fatty fish and fish oil and antioxidants vitamin A and Lutein may be effective in delay the progression of genetic degenerative eye disease, retinitis pigmentosa, but larger sample size and multi centers studies to improve their validation are necessary. Please make sure you follow the guideline of the Institute of Medicine of the National Academies. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
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References
(1) Retinitis pigmentosa (PubMed)
(2) Retinitis Pigmentosa ~ Overview(The foundation fighting blindness)
(3) Bilberry(Wikipedia)
(4) Bilberry(Herbs2000.com)
(5) Bilberry and its Constituents(MDidea)
(6) Effect of fermented bilberry extracts on visual outcomes in eyes with myopia: a prospective, randomized, placebo-controlled study by Kamiya K1, Kobashi H, Fujiwara K, Ando W, Shimizu K.(PubMed)
(7) Bilberry (Vaccinium myrtillus L.) by Chu W, Cheung SCM, Lau RAW, Benzie IFF.(PubMed)
(8) Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism by Miyake S1, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y.(PubMed)
(9) Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured human corneal limbal epithelial cells (HCLEC) by Song J1, Li Y, Ge J, Duan Y, Sze SC, Tong Y, Shaw PC, Ng TB, Tsui KC, Zhuo Y, Zhang KY.(PubMed)
(10) Reported effects of non-traditional treatments and complementary and alternative medicine by retinitis pigmentosa patients by Kiser AK1, Dagnelie G.(PubMed)
(11) Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro by Ogawa K, Kuse Y, Tsuruma K, Kobayashi S, Shimazawa M, Hara H.(PubMed)
(12) Alterations in retinal rod outer segment fatty acids and light-damage susceptibility in P23H rats by Bicknell IR1, Darrow R, Barsalou L, Fliesler SJ, Organisciak DT.(PubMed)
(13) The evidence for efficacy of omega-3 fatty acids in preventing or slowing the progression of retinitis pigmentosa: a systematic review, by Hodge WG1, Barnes D, Schachter HM, Pan YI, Lowcock EC, Zhang L, Sampson M, Morrison A, Tran K, Miguelez M, Lewin G.(PubMed)
(14) Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses by Berson EL1, Rosner B, Sandberg MA, Weigel-DiFranco C, Moser A, Brockhurst RJ, Hayes KC, Johnson CA, Anderson EJ, Gaudio AR, Willett WC, Schaefer EJ.(PubMed)
(15) Red blood cell membrane phosphatidylethanolamine fatty acid content in various forms of retinitis pigmentosa by Schaefer EJ1, Robins SJ, Patton GM, Sandberg MA, Weigel-DiFranco CA, Rosner B, Berson EL.(PubMed)
(16) Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients by Simonelli F1, Manna C, Romano N, Nunziata G, Voto O, Rinaldi E.(PubMed)
(17) Vitamin A and fish oils for retinitis pigmentosa by Rayapudi S1, Schwartz SG, Wang X, Chavis P.(PubMed)
(18) Antioxidants and vision health: facts and fiction by Grover AK1, Samson SE.(PubMed)
(19) Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient by Baumgartner WA1, Baumgartner AM(PubMed)
(20) Vitamin A derivatives as treatment options for retinal degenerative diseases by Perusek L1, Maeda T.(PubMed)
(21) The dependence of retinal degeneration caused by the rhodopsin P23H mutation on light exposure and vitamin a deprivation by Tam BM1, Qazalbash A, Lee HC, Moritz OL.(PubMed)
(22) Management of a South African family with retinitis pigmentosa-should potential therapy influence translational research protocols? by Roberts L, Rebello G, Ramesar R, Greenberg J.(PubMed)
(23) [Diet and management of degenerative diseases of the retina (retinitis pigmentosa)].[Article in Italian] by Miggiano GA1, Falsini B(PubMed)
(24) Sector retinitis pigmentosa by Van Woerkom C1, Ferrucci S.(PubMed)
(25) Vitamin E inhibits retinal pigment epithelium cell proliferation in vitro by Mojon D1, Boscoboinik D, Haas A, Bohnke M, Azzi A(PubMed)
(26) Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year follow-up study by Pasantes-Morales H1, Quiroz H, Quesada O.(PubMed)
(27) A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa by Berson EL1, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, Weigel-DiFranco C, Willett W.(PubMed)
(28) Antioxidants and vision health: facts and fiction by Grover AK1, Samson SE.(PubMed)
(29) Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A by Berson EL1, Rosner B, Sandberg MA, Weigel-DiFranco C, Brockhurst RJ, Hayes KC, Johnson EJ, Anderson EJ, Johnson CA, Gaudio AR, Willett WC, Schaefer EJ.(PubMed)
(30) Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289] by Bahrami H1, Melia M, Dagnelie G.(PubMed)
(31) Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome by Aleman TS1, Duncan JL, Bieber ML, de Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG, Jacobson SG.(PubMed)
(32) Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet by Dagnelie G1, Zorge IS, McDonald TM.(PubMed)
Retinitis pigmentosa is a genetic degenerative of eye diseases characteristic of slowly progressive damage of the retina, affecting about 1 in 4,000 people in the United States(1) and about 1in 3500 Canadians.(2).
Epidemiological studies, linking certain herbs, foods and vitamins in delay and alleviation of symptoms of the disease have produced certain success, but large sample size and multi centers studies are necessary to improve the validation of the claims.
A. The herbs
Limitation of research in finding the natural treatment for Retinitis pigmentosa, may be due to its genetically mutative nature.
Bilberry is low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to
the temperate and subarctic regions of the world(3). The herb has been used in folk medicine for its astringent action, an antihistamine effect, and it is also believe to posses anti-microbial as well as anti-diarrheal effects(4), due to its antioxidants effects of delphinidin, cyanidin, petunidin, peonidin, malvidin, etc.(5). According to epidemiological studies. although with limitation, bilberry may be beneficiary in delayed progression and alleviated symptoms of Retinitis pigmentosa due to its effectiveness in protection of vision against many forms of eye diseases.(6)(7)(8)(9). According to 1Johns Hopkins University, in Ninety-six Retinitis pigmentosa (RP) patients with any level of vision completed an anonymous internet survey. bilberry supplement was used in 32% of the correspondents, who were experiencing some impact on vision and physical/emotional well-being(10). In a blue light, a high-energy or short-wavelength visible light induced retinal diseases such as age-related macular degeneration and genetic related retinitis pigmentosa, bilberry extract (B-ext), containing high amounts of polyphenols (anthocyanins, resveratrol, and proanthocyanidins) exhibited its effects in improved the viability of 661 W cells and inhibited the generation of intracellular ROS induced by blue LED light irradiation, probably through inhibited the activation of p38 MAPK and NF-kappaB and caspase-3/7 activation and autophagy(11). Other herbs may also contain similar effects as bilberry such as lingo berry or cowberry(11).
B. The foods
1. The fatty fish and fish oil
Linseed oil or fish oil may have a potential in delay the progression in genetic eye disorder of Retinitis pigmentosa, In retinas of RP rat model, the combination of linseed and fish oil exhibited lower-than-normal levels of ROS DHA may reflect an adaptive, possibly protective, mechanism in the P23H(12). In the University of Ottawa study, Onega 3 fatty acid found abundantly in fish oil showed in improvement of some retinitis pigmentosa outcomes in Clinical preliminary research in this field, further studies are necessary(13). Docosahexaenoic acid (DHA), an other chemical derived from Omega 3 fatty acid, found abundantly in cold water fatty fish, such as salmon, in the study by the Harvard Medical School, showed a positive effect in among patients who were not taking vitamin A prior to entry, those in the DHA + A group had a slower decline in field sensitivity and electroretinogram amplitude than those in the control + A group over the first 2 years(14). Due to the influences of membrane phospholipid fatty acid abnormalities(15), some researchers suggested Fatty acid content alterations in membrane phospholipids of red blood cells of patients with Retinitis pigmentosa may be considered as markers for abnormalities in the lipid metabolism which disturb the retina integrity(16). Unfortunately, according to Johns Hopkins Bloomberg School of Public Health, in the review of the existent data of 394 titles and abstracts and nine ClinicalTrials.gov records and included three RCTs that met eligibility criteria, indicated a no clear evidence for benefit of treatment with DHA for people with RP(13).
2. The coffee
Chlorogenic acid, found in green coffee extract or Coffee, in this prospective, non-comparative, single-arm study, showed a beneficial effect on the peripheral area at the margins of retinal degeneration, and should be considered as an anti-oxidant for the management of retinitis pigmentosa(17)
C. The antioxidants
Antioxidants, may be potential in delay the progression and management of retinitis pigmentosa, according to aster University, when initial signs of vision health deterioration are observed, the appropriate nutritional supplement products may be recommended but only to augment the primary medical treatments(18). Dr. Baumgartner WA and Dr. Baumgartner AM. in one patient study to test a developed and tested a treatment regimen with a range of antioxidants in combination with the off-label use of deprenyl (1 mg/day), a safe antiapoptotic agent, for 140 months indicated a significant improvement as patient's right eye visual field showed 0% decline and left eye 13.3% decline of which defianted to the rate constants for logarithmic decline of visual field measured prior to treatment as visual fields would have decreased by 64% and 70%, respectively by month 140 in the absence of treatment(19).
1. Vitamin A
Vitamin A is a general term of Vitamin A Retinol, retinal, beta-carotene, alpha-carotene, gamma-carotene, and beta-cryptoxanthin best known for its functions for vision health and antioxidant scavenger and essential for growth and differentiation of a number of cells and tissues.
Recommended intakes of vitamin A, according to the Institute of Medicine of the National Academies (formerly National Academy of Sciences) is 600 µg daily as extremely high doses (>9000 mg) can be toxicity as causes of dry, scaly skin, fatigue, nausea, loss of appetite, bone and joint pains, headaches, etc.
Suggestion of the pathology of 11-cis-retinal deficiency caused by gene mutations may result in human retinal diseases that cause blindness, such as Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP)(20) due to involvement in the interaction of light with rhodopsin rather than with free chromophore or bleached rhodopsin(21). In autosomal dominant retinitis pigmentosa patients, vitamin A supplements may be beneficiary for some patients with retinitis pigmentosa, especiallt in patients with autosomal dominant, according to Dr. Roberts L and research team(22). In the regard of Vitamin A's effectiveness in delaying progression of the disease, researchers at the 1Centro di Ricerca in Nutrizione suggested " a lifetime generous supplementation of retinol is advisable, together with a vitamin A-rich diet and/or a dietary supplement (e.g. carrot flour) or pharmacologic supplement of vitamin A. Supply of vitamin A in doses up to 25000 IU (7500 igr/day), even for several years, has so far proved safe from risk of occurrence of liver disease"(23). Although it is controversial, some researchers suggested 15,000 IU of vitamin A palmitate per day may slow the progression, Low vision rehabilitation, long wavelength pass filters, and pedigree counseling remain the mainstay of management(24).
2. Vitamin E
Vitamin E, a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity(2), found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..
Vitamin E supplementation may improve symptoms and prevent the progression of Retinitis pigmentosa as its variant alpha-tocopherol (vitamin E) inhibited proliferation of human RPE in culture without exerting cytotoxic effects.(25). According to the National University of Mexico, in the study of the formula taurine/diltiazem/vitamin E on the progression of visual field loss in retinitis pigmentosa indicated a improving changes in the, slope values with decreasing the rate of visual field loss, likely through a protective action from free radical reactions in affected photoreceptors(26). Unfortunately, the study of supplements of vitamin A or vitamin E alone or in combination in the affect of the course of retinitis pigmentosa, suggested a positive effect in delay and progress of the diseases with 15,000 IU/d of vitamin A but an adverse effect of 400 IU/d of vitamin E on the course of retinitis pigmentosa(27) and vitamin E should be avoided(28).
3. Lutein
Lutien a xanthophyll, belonging to the family of carotenoids, found abundantly in green leafy vegetables such as spinach, kale, yellow carrots, etc., plays an important role in modulation of light energy and protection of retina against damage of free radicals produced by blue light. Lutein supplementation may be effective in slowing visual function decline in patients with retinitis pigmentosa receiving vitamin A, according to the Harvard Medical School, dietary intake of Lutein supplementation of 12 mg/d slowed loss of midperipheral visual field on average among nonsmoking adults with retinitis pigmentosa taking vitamin A(29). The randomized double-masked placebo-controlled clinical trial [NCT00029289] conducted by the Johns Hopkins University, suggested that lutein supplementation improves visual field and also might improve visual acuity slightly, although these results should be interpreted cautiously(30). The study at the University of Pennsylvania showed no change no in central vision after 6 months of lutein supplementation, but suggested that a long-term influences on the natural history of these retinal degenerations require further study(31).
Other study also showed the potential effect in the combination application of Lutein and vitamin A in patient of Retinitis pigmentosa, as lutein improved short-term vision improvements in age-related macular degeneration--also occur in RP, especially in blue-eyed individuals; vitamin A may also increase visual field benefits(32).
Taken altogether, excluding vitamin E, even with limitation of data, herbal bilberry, fatty fish and fish oil and antioxidants vitamin A and Lutein may be effective in delay the progression of genetic degenerative eye disease, retinitis pigmentosa, but larger sample size and multi centers studies to improve their validation are necessary. Please make sure you follow the guideline of the Institute of Medicine of the National Academies. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs
http://kylejnorton.blogspot.ca/p/blog-page_24.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Retinitis pigmentosa (PubMed)
(2) Retinitis Pigmentosa ~ Overview(The foundation fighting blindness)
(3) Bilberry(Wikipedia)
(4) Bilberry(Herbs2000.com)
(5) Bilberry and its Constituents(MDidea)
(6) Effect of fermented bilberry extracts on visual outcomes in eyes with myopia: a prospective, randomized, placebo-controlled study by Kamiya K1, Kobashi H, Fujiwara K, Ando W, Shimizu K.(PubMed)
(7) Bilberry (Vaccinium myrtillus L.) by Chu W, Cheung SCM, Lau RAW, Benzie IFF.(PubMed)
(8) Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism by Miyake S1, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y.(PubMed)
(9) Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured human corneal limbal epithelial cells (HCLEC) by Song J1, Li Y, Ge J, Duan Y, Sze SC, Tong Y, Shaw PC, Ng TB, Tsui KC, Zhuo Y, Zhang KY.(PubMed)
(10) Reported effects of non-traditional treatments and complementary and alternative medicine by retinitis pigmentosa patients by Kiser AK1, Dagnelie G.(PubMed)
(11) Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro by Ogawa K, Kuse Y, Tsuruma K, Kobayashi S, Shimazawa M, Hara H.(PubMed)
(12) Alterations in retinal rod outer segment fatty acids and light-damage susceptibility in P23H rats by Bicknell IR1, Darrow R, Barsalou L, Fliesler SJ, Organisciak DT.(PubMed)
(13) The evidence for efficacy of omega-3 fatty acids in preventing or slowing the progression of retinitis pigmentosa: a systematic review, by Hodge WG1, Barnes D, Schachter HM, Pan YI, Lowcock EC, Zhang L, Sampson M, Morrison A, Tran K, Miguelez M, Lewin G.(PubMed)
(14) Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses by Berson EL1, Rosner B, Sandberg MA, Weigel-DiFranco C, Moser A, Brockhurst RJ, Hayes KC, Johnson CA, Anderson EJ, Gaudio AR, Willett WC, Schaefer EJ.(PubMed)
(15) Red blood cell membrane phosphatidylethanolamine fatty acid content in various forms of retinitis pigmentosa by Schaefer EJ1, Robins SJ, Patton GM, Sandberg MA, Weigel-DiFranco CA, Rosner B, Berson EL.(PubMed)
(16) Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients by Simonelli F1, Manna C, Romano N, Nunziata G, Voto O, Rinaldi E.(PubMed)
(17) Vitamin A and fish oils for retinitis pigmentosa by Rayapudi S1, Schwartz SG, Wang X, Chavis P.(PubMed)
(18) Antioxidants and vision health: facts and fiction by Grover AK1, Samson SE.(PubMed)
(19) Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient by Baumgartner WA1, Baumgartner AM(PubMed)
(20) Vitamin A derivatives as treatment options for retinal degenerative diseases by Perusek L1, Maeda T.(PubMed)
(21) The dependence of retinal degeneration caused by the rhodopsin P23H mutation on light exposure and vitamin a deprivation by Tam BM1, Qazalbash A, Lee HC, Moritz OL.(PubMed)
(22) Management of a South African family with retinitis pigmentosa-should potential therapy influence translational research protocols? by Roberts L, Rebello G, Ramesar R, Greenberg J.(PubMed)
(23) [Diet and management of degenerative diseases of the retina (retinitis pigmentosa)].[Article in Italian] by Miggiano GA1, Falsini B(PubMed)
(24) Sector retinitis pigmentosa by Van Woerkom C1, Ferrucci S.(PubMed)
(25) Vitamin E inhibits retinal pigment epithelium cell proliferation in vitro by Mojon D1, Boscoboinik D, Haas A, Bohnke M, Azzi A(PubMed)
(26) Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year follow-up study by Pasantes-Morales H1, Quiroz H, Quesada O.(PubMed)
(27) A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa by Berson EL1, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, Weigel-DiFranco C, Willett W.(PubMed)
(28) Antioxidants and vision health: facts and fiction by Grover AK1, Samson SE.(PubMed)
(29) Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A by Berson EL1, Rosner B, Sandberg MA, Weigel-DiFranco C, Brockhurst RJ, Hayes KC, Johnson EJ, Anderson EJ, Johnson CA, Gaudio AR, Willett WC, Schaefer EJ.(PubMed)
(30) Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289] by Bahrami H1, Melia M, Dagnelie G.(PubMed)
(31) Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome by Aleman TS1, Duncan JL, Bieber ML, de Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG, Jacobson SG.(PubMed)
(32) Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet by Dagnelie G1, Zorge IS, McDonald TM.(PubMed)
Food therapy - Celery and lung cancer
Celery is a species of Apium graveolens, belonging to the family Apiaceae.
It is cultivated all around the globe as a vegetable. Celery can grow
to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape
joined at a common base.
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Celery and lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.
The study of dietary intake of vegetables and fruit and lung cancer risk in Harbin, Heilongjiang province, northeast China(b) and Tin Corporation (YTC) miners in Yunnan(c), showed a positive effect of intake of celery daily in reduced risk of lung cancer. According to Dr. Belanger JT. research, Perillyl alcohol, a monoterpene isolated from the essential oils of celery seeds, exhibited the effect of inducing apoptosis in tumor cells without affecting normal cells and reverting tumor cells back to a differentiated state in very cancer cells, including lung cancer, through increased mannose-6-phosphate/insulin-like growth factor II receptors, tissue growth factor beta receptors, Bak and decreased ras protein prenylation, ubiquinone synthesis, and induced Phase I and Phase II detoxification systems(d).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Dietary intake of fruit and vegetable and lung cancer risk: a case-control study in Harbin, northeast China by Galeone C1, Negri E, Pelucchi C, La Vecchia C, Bosetti C, Hu J.(PubMed)
(c) [A cohort study on the relationship between vegetable intake and risks of lung cancer in the Tin Corporation (YTC) miners in Yunnan].[Article in Chinese] by Lu Q1, Yao S, Huang C, Lan Y, Cang S, Qiao Y, Wang R.(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.
Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Celery and lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.
The study of dietary intake of vegetables and fruit and lung cancer risk in Harbin, Heilongjiang province, northeast China(b) and Tin Corporation (YTC) miners in Yunnan(c), showed a positive effect of intake of celery daily in reduced risk of lung cancer. According to Dr. Belanger JT. research, Perillyl alcohol, a monoterpene isolated from the essential oils of celery seeds, exhibited the effect of inducing apoptosis in tumor cells without affecting normal cells and reverting tumor cells back to a differentiated state in very cancer cells, including lung cancer, through increased mannose-6-phosphate/insulin-like growth factor II receptors, tissue growth factor beta receptors, Bak and decreased ras protein prenylation, ubiquinone synthesis, and induced Phase I and Phase II detoxification systems(d).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Dietary intake of fruit and vegetable and lung cancer risk: a case-control study in Harbin, northeast China by Galeone C1, Negri E, Pelucchi C, La Vecchia C, Bosetti C, Hu J.(PubMed)
(c) [A cohort study on the relationship between vegetable intake and risks of lung cancer in the Tin Corporation (YTC) miners in Yunnan].[Article in Chinese] by Lu Q1, Yao S, Huang C, Lan Y, Cang S, Qiao Y, Wang R.(PubMed)
(d) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
Phytochemical allicin and Stomach cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
The health effects
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin on gastric cancer cells, allicin induced apoptosis and inhibited proliferation in gastric cancer cells, through induced cytochrome c release from the mitochondria and increased caspase-3, -8, and -9 activation, with concomitant upregulation of bax and fas expression in the tumor cells. In the effect of allicin on cell proliferation and apoptosis of progressive gastric carcinoma, allicin showed effects in up-regulating the protein expressions of apoptosis promoting gene Bax and apoptosis initiating gene Fas, and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
The health effects
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin on gastric cancer cells, allicin induced apoptosis and inhibited proliferation in gastric cancer cells, through induced cytochrome c release from the mitochondria and increased caspase-3, -8, and -9 activation, with concomitant upregulation of bax and fas expression in the tumor cells. In the effect of allicin on cell proliferation and apoptosis of progressive gastric carcinoma, allicin showed effects in up-regulating the protein expressions of apoptosis promoting gene Bax and apoptosis initiating gene Fas, and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
Monday, 7 April 2014
Skin aging in Vitamin B5 points of view
By Kyle J. Norton
Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin B5, also known as Pantothenic acid, is a water-soluble vitamin found abundantly in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. The vitamin plays an important role in synthesized and metabolized proteins, carbohydrates, and fats.
According to 1Nutrition Science Solutions LLC, in the study of Hass avocados, containing high amounts of pantothenic acid and other antioxidants, showed a positive effect in supported cardiovascular health and might support weight management and healthy aging(1). A facial lotion containing vitamins B3 and E and provitamin B5, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin in a total of 246 women randomized to treatment, 207 (84%) completed the study(2). Panthenyl triacetate, a Water- and oil-soluble derivative of pantothenic acid (vitamin B5) used combination with Ethyl linoleate (bioactive complex) and given both pre- and post-irradiation, showed to stimulate the repairing enzyme expression caused by skin photo-ageing induced accumulation of oxidized protein(3). Composition of Dead Sea (DS) mud and other ingredients like DS water, zinc oxide, aloe-vera extract, pro-vitamin B5 and vitamin E, exhibited its protective, anti-oxidant and anti-inflammatory properties antagonized biological effects of UVB irradiation in skin(4). Topical application of Dexpanthenol, a supplemental source of pantothetic acid considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks, according to the study by 1Technical University of Munich, Allershausen(5) and enhanced skin barrier repair and stratum corneum hydration, while reduced skin roughness and inflammation(6).
Taken altogether, vitamin B5 may be effective in reduced the onset of skin aging and aging progression through its antioxidant activity, but further studies are necessary to confirm its claim. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)
Skin aging is one of most visible process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin B5, also known as Pantothenic acid, is a water-soluble vitamin found abundantly in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. The vitamin plays an important role in synthesized and metabolized proteins, carbohydrates, and fats.
According to 1Nutrition Science Solutions LLC, in the study of Hass avocados, containing high amounts of pantothenic acid and other antioxidants, showed a positive effect in supported cardiovascular health and might support weight management and healthy aging(1). A facial lotion containing vitamins B3 and E and provitamin B5, showed a significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin in a total of 246 women randomized to treatment, 207 (84%) completed the study(2). Panthenyl triacetate, a Water- and oil-soluble derivative of pantothenic acid (vitamin B5) used combination with Ethyl linoleate (bioactive complex) and given both pre- and post-irradiation, showed to stimulate the repairing enzyme expression caused by skin photo-ageing induced accumulation of oxidized protein(3). Composition of Dead Sea (DS) mud and other ingredients like DS water, zinc oxide, aloe-vera extract, pro-vitamin B5 and vitamin E, exhibited its protective, anti-oxidant and anti-inflammatory properties antagonized biological effects of UVB irradiation in skin(4). Topical application of Dexpanthenol, a supplemental source of pantothetic acid considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks, according to the study by 1Technical University of Munich, Allershausen(5) and enhanced skin barrier repair and stratum corneum hydration, while reduced skin roughness and inflammation(6).
Taken altogether, vitamin B5 may be effective in reduced the onset of skin aging and aging progression through its antioxidant activity, but further studies are necessary to confirm its claim. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)
Phytochemical allicin and endometrium cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The benefits
Although garlic has drawn many interest in scientific community, but believe or not allicin is the least. In the study of the effect of allicin's antiproliferative effect in vitro models, showed a significantly inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM) attributed to the ability of allicin to transiently deplete the intracellular GSH level(1). Other study also indicated that this main flavor compound in garlic, has exerted its anti-carcinogenic activities against a wide range of cancer cells. U87MG is one of a number of cell lines derived from malignant glioma was inhibited, causing apoptosis of cells by allicin in a dose- and time-dependent manner, involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems(2).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y.(PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH.(PubMed)
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The benefits
Although garlic has drawn many interest in scientific community, but believe or not allicin is the least. In the study of the effect of allicin's antiproliferative effect in vitro models, showed a significantly inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM) attributed to the ability of allicin to transiently deplete the intracellular GSH level(1). Other study also indicated that this main flavor compound in garlic, has exerted its anti-carcinogenic activities against a wide range of cancer cells. U87MG is one of a number of cell lines derived from malignant glioma was inhibited, causing apoptosis of cells by allicin in a dose- and time-dependent manner, involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems(2).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y.(PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH.(PubMed)
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