Cat's claw found in in the tropical jungles of South
and Central America, is a genus Uncaria, belonging to the family
Rubiaceae. It has been used in traditional medicine over two thousand
years as a tonic, contraceptive, anti-inflammatory and infectious
agent, and to treat diarrhea, rheumatic disorders, acne, diabetes,
cancer and diseases of the urinary tract, etc..
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that
supply the ducts with milk. there is also rare cases that breast cancer
starts in other areas of the breast. In 2010, over 250,000 new cases of
breast cancer were expected to be diagnosed in women in the U.S. alone
and the risk of getting invasive breast cancer during life time of a
women is 1/8.
Ingredients
The chemical constustuents of Cat's claw include, ajmalicine,
akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic
acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin,
harman, hirsuteine, hirsutine, iso-pteropodine, etc.
The benefits
Claw's claw has been used in folk medicine in South-American history for treatment of cancers,
arthritis, gastritis and epidemic diseases. In previous article, Cat's
claw has exerted its anti breast caner activity in MT-3 cell lines as
well as some other forms of cancers, but in other study of some extracts
and their chromatographic fractions from Cat's claw, researcher found
that beside possessed antimutagenic activity, the extracts and
fractions also consisted a direct antiproliferative activity on MCF7
cell line, with about 90% of inhibition at a concentration of 100 mg/ml.
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Side effects
1. It may cause allergic reaction, including itching, rash and allergic inflammation of the kidneys, etc. to certain people, according to the article of `Uncaria Tomentosa`by Wikipedia(a)
2. If you are taking blood pressure medicines, blood-thinning medications, hormones, or insulin do not take cat's claw
3. Do not take Cat's claw if you are pregnant or breast feeding with out approval of your related field specialist
4. Do not take cat’s claw if you have low blood pressure or an
autoimmune disease (such as lupus or multiple sclerosis) or have had an
organ or bone marrow transplant.
5. Etc.
Reference
(1) Topical plant data base (Rain tree)
(2) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line bt Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)
Sunday, 2 February 2014
Saturday, 1 February 2014
Hair Loss (Androgenetic alopecia ) in herbs' Points of View
By Kyle J. Norton
Decreased hormonal secretions due to aging stimulates the production of the enzyme 5-alpha reductase to converse testosterone to gihydro-testosterones DHT, affecting hair to grow back thinner or not grown back at all. DHT shrinks the follicles, causing hair thins and hair receded at the forehead, crown and temple for men and thins over the entire scalp for women. Herbal treatment for hair loss has existed throughout human history, but epidemiological studies, linking herbs effectiveness in treating hair loss have produced inconsistent results.
Androgenetic alopecia
Androgenetic alopecia is a common hair loss in men and women. In men, it causes baldness patterns, receding at the forehead. In women, the hair becomes thinner all over the head, and the hairline does not recede.
1. Thujae occidentalis
Thujae occidentalis is an evergreen coniferous tree, belonging to the cypress family, native to the United States and the southeast of Canada. the herb has been used in folk medicine in treating warts, ringworm and thrush.
In HEK 293 cell line derived from human embryonic kidney cells grown in tissue culture, with expressing human 5alpha-reductase (type 2), Thujae occidentalis semen (TOS) extract in comparison with gamma-linolenic acid and finasteride (a synthetic drug used to be for the treatment of benign prostatic hyperplasia), topically applied to fuzzy rat and androchronogenetic alopecia (AGA) mouse, showed effectiveness in treating male pattern baldness by dictating androgen conversion with higher inhibition activity of 5alpha-reductase type 2 than that of gamma-linolenic acid, but lower than that of finasteride. These result indicated that the extract may be a potent agent for treating male baldness(1).
2. Cuscuta reflexa Roxb(Dodder)
Cuscuta reflexa Roxb is a Perennial tree, belonging to the family Cuscutaceae, native to the Eastern Asia. Petroleum ether extract of C. reflexa, in the experiment used as a topical application, showed the Inhibition of 5alpha-reductase activity, exhibited hair growth-promoting activity, by blocking conversion of testosterone to dihydrotestosterone which causes hair receded,(2).
3. Citrullus colocynthis Schrad
Citrullus colocynthis is a desert viny plant native to the Mediterranean Basin and Asia. The herb has been used in folk medicine for treatments of cancer, carcinoma, endothelioma, leukemia, corns, tumors, etc. In androgen-induced alopecia mice, the petroleum ether extract of C. colocynthis showed an effectiveness in enhancing follicular density, exhibited hair growth-promoting activity in anagenic phase than the standard finasteride(3).
4. Eclipta alba(false daisy)
Eclipta alba is a species of E. prostrata , belonging to the family Asteraceae, native to India, China, Thailand, and Brazil. The herb has been used in folk medicine for treatments of combating swelling, inflammation, skin conditions, etc.. Petroleum ether and ethanol extract of E. alba Hassk in comparison with minoxidil 2% in rat study, exhibit hair growth pattern better than the positive control minoxidil 2% with significantly reduced time for complete hair growth.(4)
5. Garlic
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc., Experiment of garlic gel in promoting hair growth showed a positive response in enhancing the application of topical betamethasone valerate(5).
6. Onion
The onion is a plants in the genus Allium, belongs to the family Alliaceae, a close relation of garlic. It It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet. Topical crude onion juice in the study against hair loss, exhibited Re-growth of terminal coarse hairs after two weeks of application, in significantly higher among males compared to females, after 4 weeks(6).
7. Polygonum multiflorum
He Shou wu is also known as Chinese Knotweed, genus Fallopia, belonging to Polygonaceae, native to central and southern China. It has been used in traditional Chinese medicine in treating hyperlipemia, neurasthenia, split personality, premature white hair, nerve injuries, skin wind rash, constipation, etc.. Ethanol extract from Polygonum multiflorum roots in the experiment using dermal papilla cells (DPCs), showed to increase the proliferation of DPCs which plays an impotant role in enhancing hair growth and hair-fiber length significantly(7). In topically applied to the shaved dorsal skin of telogenic C57BL6/N mice, the extract stimulated hair growth by inducing anagen phase and the number and the size of hair follicles(8).
8. Platycladus
Thuja orientalis is a evergreen coniferous tree belonging to the family Cupressaceae, native to northwestern China. The herbs has been used in traditional medicine in treating baldness and hair loss in East Asia. T. orientalis extract, in the experiment of topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, induced an earlier anagen phase and prolonged the mature anagen phase, reduced earlier induction of β-catenin and Shh proteins in hair follicles. These result indicated that Thuja orientalis may be beneficiary as a potential hair growth-promoting agent.(9).
9. Asiasari radix(Chinese wild ginger root)
Asiasari radix has been used in Asian traditionally medicine for treating hair loss in to stimulate hair growth. In female C57BL/6 and C3H mice, Topical application onto the backs of Asiasari radix extract showed an effectiveness in promoting hair growth and increased protein synthesis in vibrissae follicle cultures and the proliferation of both HaCaT and human DP cells in vitro.(10)
10. Sophora flavescens
Sophora flavescens is a species of genus Sophora, belonging to family Fabaceae. The herb has been used in traditional medicine for treatments of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage etc. In the experiment of topical application of Sophora flavescens extract in C57BL/6 mice, enhanced on hair growth may be mediated through the regulation of growth factors in dermal papilla cells and inhibited the type II 5alpha-reductase activity(11).
11. Crinum asiaticum
Crinum asiaticum is a genus of Crimum, belonging to the family Amaryllidaceae, native to Jeju Island, Korea. The herb has been used in habal medicne for treatments of injury and inflamed joints, swellings, swollen joints, lumbago, pains and in cases of headache, fever, etc. Topical application of the EtOH extract of C. asiaticum onto the back of C57BL/6, increased the proliferation of immortalized vibrissa dermal papilla cells, cell nuclear antigen (PCNA) in the bulb region and the hair-fiber lengths of vibrissa(12). Norgalanthamine, a chemical constituent of Crinum asiaticum, also induced anagen progression of the hair shaft, increased the proliferation of immortalized vibrissa dermal papilla cells(16)
12. Ishige sinicola
Ishige sinicola is a genus of brown algae (class Phaeophyceae), belonging to the family Ishigeaceae native to native to Jeju Island, Korea. Topical application of I. sinicola extract onto the back of C57BL/6 mice inhibit anagen progression of the hair shaft and activity of the activity of 5α-reductase, increased cell proliferation vibrissa dermal papilla cells (DPCs), downregulated p27kip1 in stopping or slowing down the cell division cycle(13).
13. Acenthopanax koreanum
Acanthopanax koreanum Nakai (Araliaceae), a well-known herbal medicine in Jeju Island, Korea, has been used as a tonic agent in treating stress-related states(14). In the experiment of immortalized rat vibrissa dermal papilla cells treated with extract of A. koreanum leaves, showed an enhacement of the proliferation of dermal papilla cells, of the hair-fiber lengths of the vibrissa follicles by increasing the nuclear β-catenin level, and up-regulation of cyclin D1, cyclin E (regulating cell cycle progression) and CDK2(Cells decide at the end of mitosis to either start the next cell cycle and downregulation of the expression of p27(kip1)(Cyclin-dependent kinase inhibitor) in the dermal papilla cells(15).
14. Schisandra nigra
Schisandra nigra, a plant native to Jeju Island, South Korea. The herb has been used in traditional medicine for liver protection and treatments of nervous, respiratory system. Topical application of the EtOH extract of S. nigra onto the back of C57BL/6 mice nigra, exhibited the increased hair-fiber lengths of the vibrissa follicles, induced anagen progression of the hair shaft and increased both the expression of proliferating cell nuclear antigen (PCNA) in the bulb matrix region and the proliferation of immortalized vibrissa dermal papilla cells(17).
The enhancement of herbal medicine for treatments of hair loss, linking to inhibit anagen progression of the hair shaft and activity of 5α-reductase, increase proliferation vibrissa dermal papilla cells with little or no side effects has produced a promising result. Somedays, they may be considered as approval prominent treatments, in improving the appearance as well as quality of life by reducing the psychological stress with affordable cost. Once again, please consult you doctor or related field specialist before applying,
STOP HAIR LOSS - PERMANENTLY
Fill in Bald Spots, Stop Thinning Hair And
Restore Receding Hair Lines, Naturally
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse by Park WS, Lee CH, Lee BG, Chang IS.(PubMed)
(2) Effect of Cuscuta reflexa Roxb on androgen-induced alopecia by Pandit S, Chauhan NS, Dixit VK.(PubMed)
(3) Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia by Dhanotia R, Chauhan NS, Saraf DK, Dixit VK.(PubMed)
(4) Hair growth promoting activity of Eclipta alba in male albino rats by Roy RK, Thakur M, Dixit VK.(PubMed)
(5) Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study by Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R.(PubMed)
(6) Onion juice (Allium cepa L.), a new topical treatment for alopecia areata by Sharquie KE, Al-Obaidi HK.(PubMed)
(7) Promotion effect of constituents from the root of Polygonum multiflorum on hair growth by Sun YN, Cui L, Li W, Yan XT, Yang SY, Kang JI, Kang HK, Kim YH.(PubMed)
(8) Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice by Park HJ, Zhang N, Park DK.(PubMed)
(9) Hair growth-promoting activity of hot water extract of Thuja orientalis by Zhang NN, Park DK, Park HJ.(PubMed)
(10) The hair growth promoting effect of Asiasari radix extract and its molecular regulation. ho SS, Park SJ, Hwang SL, Lee MH, Kim CD, Lee IH, Chang SY, Rang MJ.(PubMed)
(11) The hair growth promoting effect of Sophora flavescens extract and its molecular regulation by Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK.(PubMed)
(12) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed).
(13) The promoting effect of Ishige sinicola on hair growth by Kang JI, Kim EJ, Kim MK, Jeon YJ, Kang SM, Koh YS, Yoo ES, Kang HK.(PubMed)
(14) The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice by Jung JM, Park SJ, Lee YW, Lee HE, Hong SI, Lew JH, Hong E, Shim JS, Cheong JH, Ryu JH.(PubMed)
(15)Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth by Kim SC, Kang JI, Park DB, Lee YK, Hyun JW, Koh YS, Yoo ES, Kim JA, Kim YH, Kang HK.(PubMed)
(16) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed)
(17) Promotion effect of Schisandra nigra on the growth of hair by Kang JI, Kim SC, Hyun JH, Kang JH, Park DB, Lee YJ, Yoo ES, Kang HK.(PubMed)
Decreased hormonal secretions due to aging stimulates the production of the enzyme 5-alpha reductase to converse testosterone to gihydro-testosterones DHT, affecting hair to grow back thinner or not grown back at all. DHT shrinks the follicles, causing hair thins and hair receded at the forehead, crown and temple for men and thins over the entire scalp for women. Herbal treatment for hair loss has existed throughout human history, but epidemiological studies, linking herbs effectiveness in treating hair loss have produced inconsistent results.
Androgenetic alopecia
Androgenetic alopecia is a common hair loss in men and women. In men, it causes baldness patterns, receding at the forehead. In women, the hair becomes thinner all over the head, and the hairline does not recede.
1. Thujae occidentalis
Thujae occidentalis is an evergreen coniferous tree, belonging to the cypress family, native to the United States and the southeast of Canada. the herb has been used in folk medicine in treating warts, ringworm and thrush.
In HEK 293 cell line derived from human embryonic kidney cells grown in tissue culture, with expressing human 5alpha-reductase (type 2), Thujae occidentalis semen (TOS) extract in comparison with gamma-linolenic acid and finasteride (a synthetic drug used to be for the treatment of benign prostatic hyperplasia), topically applied to fuzzy rat and androchronogenetic alopecia (AGA) mouse, showed effectiveness in treating male pattern baldness by dictating androgen conversion with higher inhibition activity of 5alpha-reductase type 2 than that of gamma-linolenic acid, but lower than that of finasteride. These result indicated that the extract may be a potent agent for treating male baldness(1).
2. Cuscuta reflexa Roxb(Dodder)
Cuscuta reflexa Roxb is a Perennial tree, belonging to the family Cuscutaceae, native to the Eastern Asia. Petroleum ether extract of C. reflexa, in the experiment used as a topical application, showed the Inhibition of 5alpha-reductase activity, exhibited hair growth-promoting activity, by blocking conversion of testosterone to dihydrotestosterone which causes hair receded,(2).
3. Citrullus colocynthis Schrad
Citrullus colocynthis is a desert viny plant native to the Mediterranean Basin and Asia. The herb has been used in folk medicine for treatments of cancer, carcinoma, endothelioma, leukemia, corns, tumors, etc. In androgen-induced alopecia mice, the petroleum ether extract of C. colocynthis showed an effectiveness in enhancing follicular density, exhibited hair growth-promoting activity in anagenic phase than the standard finasteride(3).
4. Eclipta alba(false daisy)
Eclipta alba is a species of E. prostrata , belonging to the family Asteraceae, native to India, China, Thailand, and Brazil. The herb has been used in folk medicine for treatments of combating swelling, inflammation, skin conditions, etc.. Petroleum ether and ethanol extract of E. alba Hassk in comparison with minoxidil 2% in rat study, exhibit hair growth pattern better than the positive control minoxidil 2% with significantly reduced time for complete hair growth.(4)
5. Garlic
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc., Experiment of garlic gel in promoting hair growth showed a positive response in enhancing the application of topical betamethasone valerate(5).
6. Onion
The onion is a plants in the genus Allium, belongs to the family Alliaceae, a close relation of garlic. It It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet. Topical crude onion juice in the study against hair loss, exhibited Re-growth of terminal coarse hairs after two weeks of application, in significantly higher among males compared to females, after 4 weeks(6).
7. Polygonum multiflorum
He Shou wu is also known as Chinese Knotweed, genus Fallopia, belonging to Polygonaceae, native to central and southern China. It has been used in traditional Chinese medicine in treating hyperlipemia, neurasthenia, split personality, premature white hair, nerve injuries, skin wind rash, constipation, etc.. Ethanol extract from Polygonum multiflorum roots in the experiment using dermal papilla cells (DPCs), showed to increase the proliferation of DPCs which plays an impotant role in enhancing hair growth and hair-fiber length significantly(7). In topically applied to the shaved dorsal skin of telogenic C57BL6/N mice, the extract stimulated hair growth by inducing anagen phase and the number and the size of hair follicles(8).
8. Platycladus
Thuja orientalis is a evergreen coniferous tree belonging to the family Cupressaceae, native to northwestern China. The herbs has been used in traditional medicine in treating baldness and hair loss in East Asia. T. orientalis extract, in the experiment of topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, induced an earlier anagen phase and prolonged the mature anagen phase, reduced earlier induction of β-catenin and Shh proteins in hair follicles. These result indicated that Thuja orientalis may be beneficiary as a potential hair growth-promoting agent.(9).
9. Asiasari radix(Chinese wild ginger root)
Asiasari radix has been used in Asian traditionally medicine for treating hair loss in to stimulate hair growth. In female C57BL/6 and C3H mice, Topical application onto the backs of Asiasari radix extract showed an effectiveness in promoting hair growth and increased protein synthesis in vibrissae follicle cultures and the proliferation of both HaCaT and human DP cells in vitro.(10)
10. Sophora flavescens
Sophora flavescens is a species of genus Sophora, belonging to family Fabaceae. The herb has been used in traditional medicine for treatments of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage etc. In the experiment of topical application of Sophora flavescens extract in C57BL/6 mice, enhanced on hair growth may be mediated through the regulation of growth factors in dermal papilla cells and inhibited the type II 5alpha-reductase activity(11).
11. Crinum asiaticum
Crinum asiaticum is a genus of Crimum, belonging to the family Amaryllidaceae, native to Jeju Island, Korea. The herb has been used in habal medicne for treatments of injury and inflamed joints, swellings, swollen joints, lumbago, pains and in cases of headache, fever, etc. Topical application of the EtOH extract of C. asiaticum onto the back of C57BL/6, increased the proliferation of immortalized vibrissa dermal papilla cells, cell nuclear antigen (PCNA) in the bulb region and the hair-fiber lengths of vibrissa(12). Norgalanthamine, a chemical constituent of Crinum asiaticum, also induced anagen progression of the hair shaft, increased the proliferation of immortalized vibrissa dermal papilla cells(16)
12. Ishige sinicola
Ishige sinicola is a genus of brown algae (class Phaeophyceae), belonging to the family Ishigeaceae native to native to Jeju Island, Korea. Topical application of I. sinicola extract onto the back of C57BL/6 mice inhibit anagen progression of the hair shaft and activity of the activity of 5α-reductase, increased cell proliferation vibrissa dermal papilla cells (DPCs), downregulated p27kip1 in stopping or slowing down the cell division cycle(13).
13. Acenthopanax koreanum
Acanthopanax koreanum Nakai (Araliaceae), a well-known herbal medicine in Jeju Island, Korea, has been used as a tonic agent in treating stress-related states(14). In the experiment of immortalized rat vibrissa dermal papilla cells treated with extract of A. koreanum leaves, showed an enhacement of the proliferation of dermal papilla cells, of the hair-fiber lengths of the vibrissa follicles by increasing the nuclear β-catenin level, and up-regulation of cyclin D1, cyclin E (regulating cell cycle progression) and CDK2(Cells decide at the end of mitosis to either start the next cell cycle and downregulation of the expression of p27(kip1)(Cyclin-dependent kinase inhibitor) in the dermal papilla cells(15).
14. Schisandra nigra
Schisandra nigra, a plant native to Jeju Island, South Korea. The herb has been used in traditional medicine for liver protection and treatments of nervous, respiratory system. Topical application of the EtOH extract of S. nigra onto the back of C57BL/6 mice nigra, exhibited the increased hair-fiber lengths of the vibrissa follicles, induced anagen progression of the hair shaft and increased both the expression of proliferating cell nuclear antigen (PCNA) in the bulb matrix region and the proliferation of immortalized vibrissa dermal papilla cells(17).
The enhancement of herbal medicine for treatments of hair loss, linking to inhibit anagen progression of the hair shaft and activity of 5α-reductase, increase proliferation vibrissa dermal papilla cells with little or no side effects has produced a promising result. Somedays, they may be considered as approval prominent treatments, in improving the appearance as well as quality of life by reducing the psychological stress with affordable cost. Once again, please consult you doctor or related field specialist before applying,
STOP HAIR LOSS - PERMANENTLY
Fill in Bald Spots, Stop Thinning Hair And
Restore Receding Hair Lines, Naturally
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse by Park WS, Lee CH, Lee BG, Chang IS.(PubMed)
(2) Effect of Cuscuta reflexa Roxb on androgen-induced alopecia by Pandit S, Chauhan NS, Dixit VK.(PubMed)
(3) Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia by Dhanotia R, Chauhan NS, Saraf DK, Dixit VK.(PubMed)
(4) Hair growth promoting activity of Eclipta alba in male albino rats by Roy RK, Thakur M, Dixit VK.(PubMed)
(5) Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study by Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R.(PubMed)
(6) Onion juice (Allium cepa L.), a new topical treatment for alopecia areata by Sharquie KE, Al-Obaidi HK.(PubMed)
(7) Promotion effect of constituents from the root of Polygonum multiflorum on hair growth by Sun YN, Cui L, Li W, Yan XT, Yang SY, Kang JI, Kang HK, Kim YH.(PubMed)
(8) Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice by Park HJ, Zhang N, Park DK.(PubMed)
(9) Hair growth-promoting activity of hot water extract of Thuja orientalis by Zhang NN, Park DK, Park HJ.(PubMed)
(10) The hair growth promoting effect of Asiasari radix extract and its molecular regulation. ho SS, Park SJ, Hwang SL, Lee MH, Kim CD, Lee IH, Chang SY, Rang MJ.(PubMed)
(11) The hair growth promoting effect of Sophora flavescens extract and its molecular regulation by Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK.(PubMed)
(12) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed).
(13) The promoting effect of Ishige sinicola on hair growth by Kang JI, Kim EJ, Kim MK, Jeon YJ, Kang SM, Koh YS, Yoo ES, Kang HK.(PubMed)
(14) The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice by Jung JM, Park SJ, Lee YW, Lee HE, Hong SI, Lew JH, Hong E, Shim JS, Cheong JH, Ryu JH.(PubMed)
(15)Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth by Kim SC, Kang JI, Park DB, Lee YK, Hyun JW, Koh YS, Yoo ES, Kim JA, Kim YH, Kang HK.(PubMed)
(16) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed)
(17) Promotion effect of Schisandra nigra on the growth of hair by Kang JI, Kim SC, Hyun JH, Kang JH, Park DB, Lee YJ, Yoo ES, Kang HK.(PubMed)
Thursday, 30 January 2014
Polycystic Ovarian Syndrome (PCOs) in herbs' Points of View
Kyle J. Norton
Epidemically, increased incidence and prevalence of overweight and obesity over 3 decades in the develop world now has spread to South East Asian population, due to over 20 years of economic prosperity causes of lifestyle changes in populations with very different initial habits. Suggestions of reduced fat intake less than 30% of total calories with a low proportion of saturated fat with high in fiber from predominantly low-glycaemic-index-carbohydrate foods is recommended. Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(1)(2).
Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries interfered with the function of the normal ovaries, resulting in enlarged ovaries, hormone imbalance( excessive androgen), male pattern hair development, acne, irregular period or absence of period, weight gain and infertility. The syndrome effects over 5% of women population.
1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
Berberine (BBR), a major chemical constituents found abundantly in turmeric and plants such as goldenseal exerted its effect in improving some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS(3).
2. Korean red ginseng
Ginseng Asia is also known as Panax ginseng. Since it has been grown in the cold places in the Asian, Asian ginseng is considered as yang promoting, according to traditional Chinese medicine.
Korean red ginseng extract (KRGE) in the experiment in PCOs induced rat, using the long-acting compound estradiol valerate (EV), regulated sympathetic nerve activity by significantly lower expression of NGF protein (involved in the growth of peripheral nerve cells) and NGF mRNA(the form of RNA that carries information from DNA) involved in the abnormal process caused by steroid-induced PCO(4). Also, in the experiment of Ginseng total saponins (GTS) involved polycystic ovaries induced by a single intramuscular injection of 4 mg estradiol valerate (EV) in rats, GTS decreased the expression of NGF in ovary tissue(5).
3. Aloe vera
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.
Aloe vera gel (AVG) exhibited significant reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol and reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities, to normal in PCOS induced in Charles Foster female rats(6). On Letrozole induced polycystic ovarian, Aloe vera gel formulation exerted a protective effect against the PCOS phenotype by restoring the ovarian steroid status, and altering key production of steroids activity(7).
4. Salvia miltiorrhiza (Dan Shen)
Dan Shen is also known as Red Sage Root. The bitter and slightly cold herb has been used in TCM as antithrombotic, antihypertonic (lowering blood pressure), antimicrobial, antipyretic, anti-inflammatory, sedative agent and to treat dysmenorrhea, amenorrhea, palpable tumors, angina,restlessness, insomnia, irritability, etc., by enhancing the functions of heart and liver.
Cryptotanshinone, isolated from Salvia miltiorrhiza, in the experiment involved prenatally androgenized (PNA) rats as a model of polycystic ovary syndrome, improved estrous cycles, reduced 17-hydroxyprogesterone, androstenedione, testosterone, glucose, insulin levels, and lowered AUC-Glu(Measurements were made of the area under the curve of glucose by intravenous glucose tolerance test) and HOMA-IR( a method used to quantify insulin resistance and beta-cell function)(8).
5. Chamomile
Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for treatments of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Intraperitoneal injections of Chamomile alcoholic-extract for ten days in the testing on the biochemical and clinical parameters in a rat model of PCOS not only induced recovery from a PCO induced state in rats, but also increased dominant follicles and better endometrial tissue arrangements(9).
6. Spearmint tea
Spearmint tea is a species of Mint belonging to the Lamiaceae, native to Europe and southwest Asia. The herb has been used in folk medicine for treatment of stomach ache.
Spearmint tea inhibited the production of the levels or activity of androgen hormones in the human body may be considered as a natural agent for PCOs.(10). In Hirsutism polycystic ovarian syndrome (PCOS), drinking spearmint tea twice a day for a 1 month period, showed the significantly reduce total testosterone levels, due to the inhibition of androgen properties(11). In other study of polycystic ovary syndrome and idiopathic hirsutism, steep Spearmint tea for 5 days twice a day in the follicular phase of their menstrual cycles significant decreased in free testosterone and increased in luteinizing hormone, follicle-stimulating hormone and estradiol(12).
8. Licorice
Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy, anti inflammation, anti ulcer, anti convulsion and to treat stomach weakness, tired and lack of strength, palpitation and short of breath, cough with abundance of phlegm, stomach and solar plexus pain, etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels. Combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance. These result showed licorice may be a potent agent for reducing the prevalence of side effects related to the diuretic activity of spironolactone(13). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(14).
9. HemoHIM
HemoHIM is a herbal formula containing three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix approved by Korean FDA as health functional supplement assisting functions of the immune system. In adult cycling rats, administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection, the formula lowered the high numbers of antral follicles and increased the number of corpora lutea, normalized Ovarian morphology and the expression of nerve growth factor (NGF) in PCOs(15)
Epidemiological studies, linking many herbs such as, Green tea, Milk thistle, Rosemary, Bupleurum, barberry and Schizandra in relieving symptoms of PCOs, preventing further disease and promoting the body to heal itself have produced unfavorable results. Prevention and treatment of PCOs of herbal medicine will not be accomplished without accompanying healthy diet, life style and weight loss.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(2) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(3) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y.(PubMed).
(4) Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model by Pak SC, Kim SE, Oh DM, Shim KM, Jeong MJ, Lim SC, Nah SY, Park SH, Kang SS, Moon CJ, Kim JC, Kim SH, Bae CS.(PubMed)
(5) [Effects of ginseng total saponins on nerve growth factor expression in rat with estradiol valerate-induced polycystic ovaries].[Article in Chinese] by Kuang HY, Shao H, Hou LH, Wu XK.(PubMed)
(6) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
(7) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
(8) Cryptotanshinone reverses reproductive and metabolic disturbances in prenatally androgenized rats via regulation of ovarian signaling mechanisms and androgen synthesis, , , , , , , Elisabet Stener-Victorin(American society physiology)
(9)Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome by Farideh ZZ, Bagher M, Ashraf A, Akram A, Kazem M.(PubMed)
(10) An update on plant derived anti-androgens. by Grant P, Ramasamy S.(PubMed)
(11) Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial by Grant P.(PubMed)
(12) Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. by Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş N.(PubMed)
(13) Treatment of polycystic ovary syndrome with spironolactone plus licorice by Armanini D, Castello R, Scaroni C, Bonanni G, Faccini G, Pellati D, Bertoldo A, Fiore C, Moghetti P(PubMed)
(14) [Effects of compound ganshao paste on the levels of sex hormones and hepatic transaminases in polycystic ovarian syndrome rat model].[Article in Chinese] by Wang YH, Wang HL, Zhang YL.(PubMed)
(15) HemoHIM improves ovarian morphology and decreases expression of nerve growth factor in rats with steroid-induced polycystic ovaries by Kim SH, Lee HJ, Kim JS, Moon C, Kim JC, Bae CS, Park HR, Jung U, Jo SK.(PubMed)
Epidemically, increased incidence and prevalence of overweight and obesity over 3 decades in the develop world now has spread to South East Asian population, due to over 20 years of economic prosperity causes of lifestyle changes in populations with very different initial habits. Suggestions of reduced fat intake less than 30% of total calories with a low proportion of saturated fat with high in fiber from predominantly low-glycaemic-index-carbohydrate foods is recommended. Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(1)(2).
Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries interfered with the function of the normal ovaries, resulting in enlarged ovaries, hormone imbalance( excessive androgen), male pattern hair development, acne, irregular period or absence of period, weight gain and infertility. The syndrome effects over 5% of women population.
1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
Berberine (BBR), a major chemical constituents found abundantly in turmeric and plants such as goldenseal exerted its effect in improving some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS(3).
2. Korean red ginseng
Ginseng Asia is also known as Panax ginseng. Since it has been grown in the cold places in the Asian, Asian ginseng is considered as yang promoting, according to traditional Chinese medicine.
Korean red ginseng extract (KRGE) in the experiment in PCOs induced rat, using the long-acting compound estradiol valerate (EV), regulated sympathetic nerve activity by significantly lower expression of NGF protein (involved in the growth of peripheral nerve cells) and NGF mRNA(the form of RNA that carries information from DNA) involved in the abnormal process caused by steroid-induced PCO(4). Also, in the experiment of Ginseng total saponins (GTS) involved polycystic ovaries induced by a single intramuscular injection of 4 mg estradiol valerate (EV) in rats, GTS decreased the expression of NGF in ovary tissue(5).
3. Aloe vera
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.
Aloe vera gel (AVG) exhibited significant reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol and reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities, to normal in PCOS induced in Charles Foster female rats(6). On Letrozole induced polycystic ovarian, Aloe vera gel formulation exerted a protective effect against the PCOS phenotype by restoring the ovarian steroid status, and altering key production of steroids activity(7).
4. Salvia miltiorrhiza (Dan Shen)
Dan Shen is also known as Red Sage Root. The bitter and slightly cold herb has been used in TCM as antithrombotic, antihypertonic (lowering blood pressure), antimicrobial, antipyretic, anti-inflammatory, sedative agent and to treat dysmenorrhea, amenorrhea, palpable tumors, angina,restlessness, insomnia, irritability, etc., by enhancing the functions of heart and liver.
Cryptotanshinone, isolated from Salvia miltiorrhiza, in the experiment involved prenatally androgenized (PNA) rats as a model of polycystic ovary syndrome, improved estrous cycles, reduced 17-hydroxyprogesterone, androstenedione, testosterone, glucose, insulin levels, and lowered AUC-Glu(Measurements were made of the area under the curve of glucose by intravenous glucose tolerance test) and HOMA-IR( a method used to quantify insulin resistance and beta-cell function)(8).
5. Chamomile
Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for treatments of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Intraperitoneal injections of Chamomile alcoholic-extract for ten days in the testing on the biochemical and clinical parameters in a rat model of PCOS not only induced recovery from a PCO induced state in rats, but also increased dominant follicles and better endometrial tissue arrangements(9).
6. Spearmint tea
Spearmint tea is a species of Mint belonging to the Lamiaceae, native to Europe and southwest Asia. The herb has been used in folk medicine for treatment of stomach ache.
Spearmint tea inhibited the production of the levels or activity of androgen hormones in the human body may be considered as a natural agent for PCOs.(10). In Hirsutism polycystic ovarian syndrome (PCOS), drinking spearmint tea twice a day for a 1 month period, showed the significantly reduce total testosterone levels, due to the inhibition of androgen properties(11). In other study of polycystic ovary syndrome and idiopathic hirsutism, steep Spearmint tea for 5 days twice a day in the follicular phase of their menstrual cycles significant decreased in free testosterone and increased in luteinizing hormone, follicle-stimulating hormone and estradiol(12).
8. Licorice
Gan Cao is also known as Licorice root. The sweet and neutral herb has been used in TCM as anti allergy, anti inflammation, anti ulcer, anti convulsion and to treat stomach weakness, tired and lack of strength, palpitation and short of breath, cough with abundance of phlegm, stomach and solar plexus pain, etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing all 12 channels. Combination of licorice and 100 mg spironolactone showed the activation of the renin-aldosterone system in lowering blood pressure and water (fluid) balance. These result showed licorice may be a potent agent for reducing the prevalence of side effects related to the diuretic activity of spironolactone(13). In model rats experiment, Ganshao Paste (CGP), showed the decrease of serum levels of LH, T, and FSH and increase of serum estradiol (E2), and progesterone (P)(14).
9. HemoHIM
HemoHIM is a herbal formula containing three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix approved by Korean FDA as health functional supplement assisting functions of the immune system. In adult cycling rats, administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection, the formula lowered the high numbers of antral follicles and increased the number of corpora lutea, normalized Ovarian morphology and the expression of nerve growth factor (NGF) in PCOs(15)
Epidemiological studies, linking many herbs such as, Green tea, Milk thistle, Rosemary, Bupleurum, barberry and Schizandra in relieving symptoms of PCOs, preventing further disease and promoting the body to heal itself have produced unfavorable results. Prevention and treatment of PCOs of herbal medicine will not be accomplished without accompanying healthy diet, life style and weight loss.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(2) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(3) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y.(PubMed).
(4) Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model by Pak SC, Kim SE, Oh DM, Shim KM, Jeong MJ, Lim SC, Nah SY, Park SH, Kang SS, Moon CJ, Kim JC, Kim SH, Bae CS.(PubMed)
(5) [Effects of ginseng total saponins on nerve growth factor expression in rat with estradiol valerate-induced polycystic ovaries].[Article in Chinese] by Kuang HY, Shao H, Hou LH, Wu XK.(PubMed)
(6) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model by Desai BN, Maharjan RH, Nampoothiri LP.(PubMed)
(7) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model by Maharjan R, Nagar PS, Nampoothiri L.(PubMed)
(8) Cryptotanshinone reverses reproductive and metabolic disturbances in prenatally androgenized rats via regulation of ovarian signaling mechanisms and androgen synthesis, , , , , , , Elisabet Stener-Victorin(American society physiology)
(9)Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome by Farideh ZZ, Bagher M, Ashraf A, Akram A, Kazem M.(PubMed)
(10) An update on plant derived anti-androgens. by Grant P, Ramasamy S.(PubMed)
(11) Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial by Grant P.(PubMed)
(12) Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. by Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş N.(PubMed)
(13) Treatment of polycystic ovary syndrome with spironolactone plus licorice by Armanini D, Castello R, Scaroni C, Bonanni G, Faccini G, Pellati D, Bertoldo A, Fiore C, Moghetti P(PubMed)
(14) [Effects of compound ganshao paste on the levels of sex hormones and hepatic transaminases in polycystic ovarian syndrome rat model].[Article in Chinese] by Wang YH, Wang HL, Zhang YL.(PubMed)
(15) HemoHIM improves ovarian morphology and decreases expression of nerve growth factor in rats with steroid-induced polycystic ovaries by Kim SH, Lee HJ, Kim JS, Moon C, Kim JC, Bae CS, Park HR, Jung U, Jo SK.(PubMed)
Cruciferous vegetables and Cancer prevention
Cruciferous vegetables
are the group of vegetables belonging to the family Brassicaceae,
including cauliflower, cabbage, cress, bok choy, broccoli etc.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constutuents include glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..
The benefits
Consumption of Cruciferous vegetables is known for its interaction with with detoxification enzymes in reducing the risk of cancer. sulforaphane (SF) derived from isothiocyanates, a major phytochemical found in broccoli is associated to the tissue uptake level of SF in the body organ with increased levels of glutathione S-transferases (GSTs) and NQO1(member of the NAD(P)H dehydrogenase (quinone) family) genes varied by 3- to 6-fold among the organs of SF-treated rats. The chemopreventive properties of sulforaphane and its effect on cancer stem cells (CSCs) may be another source for initiating and maintaining cancer, as sulforaphane may target CSCs in different types of cancer through modulation of some pathways.
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Food Therapy http://kylejnorton.blogspot.ca/p/food-therapies.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
The Side effects1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.
References
(1) Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention by Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y.(PubMed)
(2) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts by Li Y, Zhang T.(PubMed)
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constutuents include glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..
The benefits
Consumption of Cruciferous vegetables is known for its interaction with with detoxification enzymes in reducing the risk of cancer. sulforaphane (SF) derived from isothiocyanates, a major phytochemical found in broccoli is associated to the tissue uptake level of SF in the body organ with increased levels of glutathione S-transferases (GSTs) and NQO1(member of the NAD(P)H dehydrogenase (quinone) family) genes varied by 3- to 6-fold among the organs of SF-treated rats. The chemopreventive properties of sulforaphane and its effect on cancer stem cells (CSCs) may be another source for initiating and maintaining cancer, as sulforaphane may target CSCs in different types of cancer through modulation of some pathways.
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Food Therapy http://kylejnorton.blogspot.ca/p/food-therapies.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
The Side effects1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.
References
(1) Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention by Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y.(PubMed)
(2) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts by Li Y, Zhang T.(PubMed)
Herbal Calendula (Calendula officinalis) and edema
Calendula is also known as pot marigold, a annual or perennial herbaceous
plants of about 12–20 species of genus Calendula, belonging to the
family Asteraceae, native to Southern Europe. It has been used in herbal
medicine as spasmolytic, spasmogenic, inflammatory effects and to treat
abdominal cramps, wound healing, skin diseases, colitis, constipation,
etc.
Edema is a condition of accumulation of fluid in the interstitial spaces, causes of swelling in the feet, ankles and legs.
Ingredients
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins
Edema is a condition of accumulation of fluid in the interstitial spaces, causes of swelling in the feet, ankles and legs.
Ingredients
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins
The benefits
Calendula officinalis flower extract has been used effectively in treating inflammatory causes of edema in a carrageenan and dextran-induced acute paw edema model by 41.9 and 42.4% respectively in oral administration of 250 and 500 mg/kg body weight, by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis. Study the anti-inflammatory activity of three new terpenoids, also indicated that the new chemical constituent found in calendula protected against inhibition of croton oil induced ear edema in mouse.
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
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References
(1) Phytochemical Constituents and PharmacologicalActivities of Calendula officinalis Linn (Asteraceae): AReview by BP Muley, SS Khadabadi and NB Banarase (Tropical Journal of Pharmaceutical Research)
(2)Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action by Preethi KC, Kuttan G, Kuttan R.(PubMed)(3) Improved anti-inflammatory activity of three new terpenoids derived, by systematic chemical modifications, from the abundant triterpenes of the flowery plant Calendula officinalis by Neukirch H, D'Ambrosio M, Sosa S, Altinier G, Della Loggia R, Guerriero A.(PubMed)
Herbal Cascara Sagrada (Rhamnus purshiana) and Prostate cancer
Cascara sagrada is a species of
buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to
western North America, it's bark has been used in traditional medicine
for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
Prostate cancer is defined as a
condition in which the cells of prostate has become cancerous, causing
abnormal cell growth which spread to the distant parts of the body.
Most prostate cancers are slow growing and enlarged prostate and
prostate cancer may be detected during the Physical (rectum) exams
The Ingredients
The chemical constituents of Cascara Sagrada
include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A,
B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones
palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
The benefits
Aloe-emodin, a chemical constituent in
Cascara Sagrada is found to inhibit both proliferation and
anchorage-independent growth of PC3 cells by targeting mTORC2. Other
major compound of emodin, Cascara Sagrada in the study of its effective
on prostate and lung cancers, showed to inhibit proliferation, induce
apoptosis, suppress angiogenesis, impede metastasis, and enhance
chemotherapy as a novel blocker of CXCR4 expression.
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
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References
(1) Aloe-emodin suppresses prostate
cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW,
Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate
and lung cancer cells by downregulating the expression of chemokine
receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS,
Choi SH, Ahn KS.(PubMed)
Phytochemical allicin and hypertension
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
The health benefits
Allicin, found in garlic and onion may consist an antihypertensive effects by lowering the systolic and diastolic blood pressure. In the study of a popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) in nine patients with rather severe hypertension, after 5 hours taking the preparation, sitting blood pressure fell 7/16, with a significant decrease in diastolic blood pressure from 5-14 hours after the dose. Other in the study of the hypotensive action of time-released garlic powder tablets (Allicor) and compared with that of regular garlic pills (Kwai) in 84 men with mild or moderate arterial hypertension, the result indicated that both Kwai and garlic powder tablets decrease in systolic blood pressure but no decrease in diastolic blood pressure was observed with Kwai. These different effects may be as a result of the prolonged action of Allicor.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html
References
(1) Can garlic lower blood pressure? A pilot study by McMahon FG, Vargas R.(PubMed)
(2) Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension by Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN.(PubMed)
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
The health benefits
Allicin, found in garlic and onion may consist an antihypertensive effects by lowering the systolic and diastolic blood pressure. In the study of a popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) in nine patients with rather severe hypertension, after 5 hours taking the preparation, sitting blood pressure fell 7/16, with a significant decrease in diastolic blood pressure from 5-14 hours after the dose. Other in the study of the hypotensive action of time-released garlic powder tablets (Allicor) and compared with that of regular garlic pills (Kwai) in 84 men with mild or moderate arterial hypertension, the result indicated that both Kwai and garlic powder tablets decrease in systolic blood pressure but no decrease in diastolic blood pressure was observed with Kwai. These different effects may be as a result of the prolonged action of Allicor.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Can garlic lower blood pressure? A pilot study by McMahon FG, Vargas R.(PubMed)
(2) Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension by Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN.(PubMed)
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