Dietary Minerals - Potassium and hypertension

Dietary Minerals are the group of minerals essential for our body to sustain normal functions and physical health.
In General, potassium is an essential mineral for our body  to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.
The effects
Administration of high potassium diets is found to be effective in lowering of blood pressure in some animal models of hypertension. Researchers suggested that the effect may be the result of diuretic action in reducing the extracellular fluid volume, thus decreased blood pressure. Others insisted that the lowering blood pressure of high potassium diet may influence the potassium modifies central or the peripheral neural mechanisms in regulating blood pressure. In fact, increase fruit and vegetable intake such as banana, papaya, mango, spinach, tomatoes, etc., may help increase dietary potassium and reduce hypertension-related disease.
Side effects
Overdose of potassium, also known as hyperkalemia may cause symptoms of hypotension, stomach cramps, diarrhea, vomiting, irritability, fatigue, etc., and in some cases, it can be life-threatening due to electrolyte abnormality.


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References
(1) Role of dietary potassium in the treatment of hypertension by Treasure J, Ploth D.(PubMed)
(2) Potassium and fruit and vegetable intakes in relation to social determinants and access to produce in New York City by Loftfield E, Yi S, Curtis CJ, Bartley K, Kansagra SM.(PubMed)
(3) Endoscopic Removal of Pharmacobezoar in Case of Intentional Potassium Overdose by Briggs AL, Deal LL.(PubMed)

Herbal Butterbur and Seasonal allergic rhinitis

Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere. It has been used in herbal medicne used as an pain reliever in digestive system, including stomach, bile ducts, and duodenum, etc.
Seasonal allergic rhinitis is a condition of inflammation of the nasal passages as a result of seasonal allergic effects.

The Ingredients
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene,  quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

The benefits
Conventional, complementary, and alternative options for seasonal allergies study showed several dietary supplements, such as butterbur and vitamin C, have some preliminary evidence of that may be beneficiary to patients with seasonal allergic rhinitis. Although butterbur has hold some promise, complementary and alternative therapies have not been integrated into the general treatment armamentarium of allergic rhinitis. Also in the study of Herbal medicines for the treatment of allergic rhinitis, butterbur extract for allergic rhinitis (AR) is superior to placebo or similarly effective compared with nonsedative antihistamines for intermittent AR, researchers insist confirmation in larger and more rigorously designed clinical trials is warranted with a large sample size.

Side effects
1. Butterbur may be liver-toxic to liver and cause cancer due to the presence of pyrrolizidine alkaloids(a)
2. If you are pregnant please do not use Butterbur with out the permission of the related special field specialist
3. Allergic effect to certain people who are allergic to ragweed, marigold, daisy, etc.
4. Overdoses may cause indigestion, headache, nausea, vomiting, diarrhea, etc.
5. Etc.

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References
(1) Conventional, complementary, and alternative options for seasonal allergies by Moyad MA.(PubMed)
(2) Complementary and alternative medicine for allergic rhinitis by Man LX.(PubMed)
(3) Herbal medicines for the treatment of allergic rhinitis: a systematic review by Guo R, Pittler MH, Ernst E.(PubMed)

Food Thrapy - Strawberries and Hypertension

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with suitable climate for commercial profits and for health benefits.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out  High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways. Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney.

Nutrients and Chemicals constituents

1. Carbohydrate
2. Dietary fiber
3. Omega 3 fatty acid
4. Calcium
5. Iron
6. Magnesium
7. Phosphorus
8. Potassium
9. Sodium
10. Zinc
11. Copper
12. Manganese
13. Selenium
14. Vitamin C
15. Thiamin
16. Niacin
17. Pantothenic acid
18. Vitamin B-6
19. Folate
20. Vitamin B-12
21. Vitamin A
22. Vitamin E
23. Vitamin K
24. Etc. 

The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin 

 

The benefits

Purified ellagitannins from strawberries were found to be effective in lowering high blood pressure and may be considered as a potential agent in management of hypertension. In the study of alpha-amylase, alpha-glucosidase, and angiotensin-1-converting enzyme (ACE) activity using fruit extracts, in general, Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension. Other in the study of the same above showed high alpha-glucosidase inhibitory activity in whole food but. However, very low in all cultivars thus low anti-hypertensive potential. 

 

The Side effects
1. Some people may beexperience anaphylactoid reaction to the consumption of strawberries

2. Oxalation
Oxalates in high concentration can cause problem for people with kidney diseases.

3. Etc.


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References

(1) Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria × ananassa Duch.) using in vitro models, by Pinto Mda S, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K(PubMed)

(2) Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension. Cheplick S, Kwon YI, Bhowmik P, Shetty K.(PubMed)

(3) Functionality of bioactive compounds in Brazilian strawberry (Fragaria x ananassa Duch.) cultivars: evaluation of hyperglycemia and hypertension potential using in vitro models. by da Silva Pinto M, Kwon YI, Apostolidis E, Lajolo FM, Genovese MI, Shetty K.

(PubMed)

Herbal Anise and Antifungal activity

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region. The popular herb has been used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, carminative, digestive, expectorant, stimulant and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Candida albicans is a member of a large group of organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that does cause harmful effects, but overgrowth results in candidiasis.

Ingredients
Beside the main ingredient Anethole, it also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

The Benefits
P-anisaldehyde (1), o-anisaldehyde (2)  found in anise is found to process the anti fungal activity against Candida, including azole-resistant strains, advocating further investigation for clinical applications in the treatment of fungal infections. In other study, anise fruits Pimpinella anisum L. (Apiaceae) extract showed antimycotic activity against Candida albicans and inhibited the growth of dermatophyte species (Trichophyton rubrum, T. mentagrophytes, Microsporum canis and M. gypseum). Anise essential oil also  exhibited stronger antifungal activities against yeasts and dermatophytes with MIC values between 0.10 and 1.56%.

The Side Effects 1. If you have high blood pressure or pregnant please consult with your doctor or related field specialist before applying.
2. Star Anise is toxic.
3. Skin Irritation
4. Allergic reaction such as mouth and lip inflammation.
5. Etc.


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References
(1) "[Apparent life-threatening event in infants: think about star anise intoxication!].[Article in French] by Perret C, Tabin R, Marcoz JP, Llor J, Cheseaux JJ.,  (PubMed)
(2) Interesting anticandidal effects of anisic aldehydes on growth and proton-pumping-ATPase-targeted activity by Shreaz S, Bhatia R, Khan N, Ahmad SI, Muralidhar S, Basir SF, Manzoor N, Khan LA.(PubMed)
(3) Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae) by Kosalec I, Pepeljnjak S, Kustrak D.(PubMed)

Herbal Andrographis and Renoprotective effects

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Renoprotective effect is defined of a protection against harmful of the kidney.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The Benefits
Renal failure is an increasingly common condition with limited treatment options in developing world. In the study to evaluate the antirenal failure activity of A. paniculata, aqueous extract of A. paniculata attenuated the gentamicin-induced increase in serum creatinine, serum urea, and blood urea nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively by exhibiting a significant renoprotective effect in gentamicin-induced nephrotoxicity in rats. Other in the study of the effect of various herbal adaptogens, including on cadmium (Cd)-induced oxidative stress and its accumulation in broiler chicken, found that  the increase in TBARS and decrease in GSH concentrations of liver and kidney tissues in cadmium intoxicated birds were significantly reversed by the above-said herbs. The liver and kidney functional markers were also restored to normal levels.  Unfortunately, Andrographolide was found to cause acute kidney injury shortly after intravenous infusion of andrographolide, with symptoms including flank pain, decreased urine output, and nausea or vomiting.
 
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
 2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.


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References 
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats by Singh P, Srivastava MM, Khemani LD.(PubMed)
(3) Andrographolide induced acute kidney injury: Analysis of 26 cases reported in Chinese Literature by Zhang WX, Zhang ZM, Zhang ZQ, Wang Y, Zhou W.(PubMed)
(4) Prevention of cadmium bioaccumulation by herbal adaptogens by Bharavi K, Reddy AG, Rao GS, Kumar PR, Kumar DS, Prasadini PP.(PubMed)

Phytochemical Anacardic acids and Prostate cancer

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

The health Benefits
Anacardic acid (6-pentadecylsalicylic acid), a natural chemical constituent from ancient plant Amphipterygium adstringens, also known as a non-specific histone acetyltransferase inhibitor of p300, beside exhibuts its anti-inflammatory, anticancer, antioxidative, and antimicrobial effects, but also revealed that Src protein expression, tumor cell proliferation, and microvessel density could be remarkably suppressed by anacardic acid and may be considered as a potent agent to treat prostate cancer. Other study of Anacardic acid (6-pentadecylsalicylic acid), also showed to inhibit of prostate cancer by  down-regulates androgen receptor (AR) through supressing p300.

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References
(1) Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway by Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X.(PubMed)
(2) Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling by Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X.(PubMed)

Phytochemicals Phytic acid and Alzheimer's disease (AD)

  Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

The benefits
 In the study of the effects of Phytic acid (inositol hexakisphosphate), a phytochemical found in food grains an others, against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model. After 48-72-hour treatment, phytic acid is founf to be provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity. 2% phytic acid in drinking water for 70 days also showed a significant increase in brain levels of cytochrome oxidase and a decrease in lipid peroxidation. Other in  the study of composition and method for the treatment of Alzheimer's disease and related amyloid plaque development and reduction of amyloid plaque, amyloidosis and amyotrophic lateral sclerosis with phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination showed that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta amyloid proteins as are commonly seen in the brains of Alzheimer's patients.


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Optimal Health And Loose Weight

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References
(1) Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)