Thursday, 9 January 2014

Herbal Anise and Antifungal activity

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region. The popular herb has been used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, carminative, digestive, expectorant, stimulant and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Candida albicans is a member of a large group of organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that does cause harmful effects, but overgrowth results in candidiasis.

Ingredients
Beside the main ingredient Anethole, it also contains, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

The Benefits
P-anisaldehyde (1), o-anisaldehyde (2)  found in anise is found to process the anti fungal activity against Candida, including azole-resistant strains, advocating further investigation for clinical applications in the treatment of fungal infections. In other study, anise fruits Pimpinella anisum L. (Apiaceae) extract showed antimycotic activity against Candida albicans and inhibited the growth of dermatophyte species (Trichophyton rubrum, T. mentagrophytes, Microsporum canis and M. gypseum). Anise essential oil also  exhibited stronger antifungal activities against yeasts and dermatophytes with MIC values between 0.10 and 1.56%.

The Side Effects 1. If you have high blood pressure or pregnant please consult with your doctor or related field specialist before applying.
2. Star Anise is toxic.
3. Skin Irritation
4. Allergic reaction such as mouth and lip inflammation.
5. Etc.


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References
(1) "[Apparent life-threatening event in infants: think about star anise intoxication!].[Article in French] by Perret C, Tabin R, Marcoz JP, Llor J, Cheseaux JJ.,  (PubMed)
(2) Interesting anticandidal effects of anisic aldehydes on growth and proton-pumping-ATPase-targeted activity by Shreaz S, Bhatia R, Khan N, Ahmad SI, Muralidhar S, Basir SF, Manzoor N, Khan LA.(PubMed)
(3) Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae) by Kosalec I, Pepeljnjak S, Kustrak D.(PubMed)

Herbal Andrographis and Renoprotective effects

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Renoprotective effect is defined of a protection against harmful of the kidney.

The Ingredients
Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.

The Benefits
Renal failure is an increasingly common condition with limited treatment options in developing world. In the study to evaluate the antirenal failure activity of A. paniculata, aqueous extract of A. paniculata attenuated the gentamicin-induced increase in serum creatinine, serum urea, and blood urea nitrogen levels by 176.92%, 106.27%, and 202.90%, respectively by exhibiting a significant renoprotective effect in gentamicin-induced nephrotoxicity in rats. Other in the study of the effect of various herbal adaptogens, including on cadmium (Cd)-induced oxidative stress and its accumulation in broiler chicken, found that  the increase in TBARS and decrease in GSH concentrations of liver and kidney tissues in cadmium intoxicated birds were significantly reversed by the above-said herbs. The liver and kidney functional markers were also restored to normal levels.  Unfortunately, Andrographolide was found to cause acute kidney injury shortly after intravenous infusion of andrographolide, with symptoms including flank pain, decreased urine output, and nausea or vomiting.
 
The Side effects
1. Antifertility
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
 2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.


Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html  

 
References 
(1) Antifertility effect of Andrographis paniculata (Nees) in male albino rat" by Akbarsha MA, Manivannan B, Hamid KS, Vijayan B., posted in (PubMed)
(2) Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats by Singh P, Srivastava MM, Khemani LD.(PubMed)
(3) Andrographolide induced acute kidney injury: Analysis of 26 cases reported in Chinese Literature by Zhang WX, Zhang ZM, Zhang ZQ, Wang Y, Zhou W.(PubMed)
(4) Prevention of cadmium bioaccumulation by herbal adaptogens by Bharavi K, Reddy AG, Rao GS, Kumar PR, Kumar DS, Prasadini PP.(PubMed)

Phytochemical Anacardic acids and Prostate cancer

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

The health Benefits
Anacardic acid (6-pentadecylsalicylic acid), a natural chemical constituent from ancient plant Amphipterygium adstringens, also known as a non-specific histone acetyltransferase inhibitor of p300, beside exhibuts its anti-inflammatory, anticancer, antioxidative, and antimicrobial effects, but also revealed that Src protein expression, tumor cell proliferation, and microvessel density could be remarkably suppressed by anacardic acid and may be considered as a potent agent to treat prostate cancer. Other study of Anacardic acid (6-pentadecylsalicylic acid), also showed to inhibit of prostate cancer by  down-regulates androgen receptor (AR) through supressing p300.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway by Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X.(PubMed)
(2) Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling by Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X.(PubMed)

Phytochemicals Phytic acid and Alzheimer's disease (AD)

  Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

The benefits
 In the study of the effects of Phytic acid (inositol hexakisphosphate), a phytochemical found in food grains an others, against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model. After 48-72-hour treatment, phytic acid is founf to be provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity. 2% phytic acid in drinking water for 70 days also showed a significant increase in brain levels of cytochrome oxidase and a decrease in lipid peroxidation. Other in  the study of composition and method for the treatment of Alzheimer's disease and related amyloid plaque development and reduction of amyloid plaque, amyloidosis and amyotrophic lateral sclerosis with phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination showed that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta amyloid proteins as are commonly seen in the brains of Alzheimer's patients.


Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html


References
(1) Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)

Phytochemical Piperine and antimicrobial activity

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The health benefits
In the study of piperine combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus, the combination showed more effective against the tested subject when compared with the commercially available formulation of 2 % mupirocin alone. Other in the study of the same subject showed the enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html

References
(1) Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus by Mirza ZM, Kumar A, Kalia NP, Zargar A, Khan IA.(PubMed)
(2) Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus by Khan IA, Mirza ZM, Kumar A, Verma V, Qazi GN.(PubMed)

Phytochemical Tartaric acid enhances intestinal absorption

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Tartaric acid is a phytichemicasl of the organic acid found abundantly in nuts, apricots, apples, sunflower, avocado, grapes, etc.

In the study of the effects of D-tartaric acid (TA) on intestinal drug absorption in rat moldel, showed a significantly increase of the intestinal absorption of P-glycoprotein (P-gp), a class of conjugated proteins. rhodamine 123 and daunorubicin. Other in the study of  starch preparations analysed for their resistance to enzymatic digestion in vitro with the presence of inorganic (hydrochloric) and organic (citric and tartaric) acids under controlled conditions. Tannic acid showed a significantly stronger influence on starch hydrolysis than citric acid.



Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Phytochemical Therapy http://kylejnorton.blogspot.ca/p/phytochemical-therapy.html


References
(1) Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid by Iida A, Tomita M, Idota Y, Takizawa Y, Hayashi M.(PubMed)
(2) New starch preparations resistant to enzymatic digestion by Jochym K, Kapusniak J, Barczynska R, Sliżewska K.(PubMed)

Wednesday, 8 January 2014

Herbal Aloe Vera and Skin Aging

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herb studied in scientific ways with some conflicted results.

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospho-lipids, DNA and RNA, etc., leading to aging of the organisms, as a result of widespread damage due to set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls. Free radicals oxidative effects can damage to skin and speed up the skin aging process.

The Ingredients 
The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
They all work together in a synergistic way to create healing and health giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

The benefits 
Aging is a natural process, no one can stop but delay it. Aloe Vera Supplementation has long been promote by cosmetic industrial for reducing the progress of skin aging. The study of 30 healthy female subjects over the age of 45 received 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days. to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin, researchers found that the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. In UVB-Induced Skin Photoaging in vitro, aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect on UVB-induced skin photoaging in normal human dermal fibroblasts (NHDFs). As a anti-inflammatory agent,  aloe vera, havs been identified as beneficial in the treatment of psoriasis and atopic dermatitis.

The Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause of rheumatoid arthritis symptoms as a result of collagen in the plant, according to the study of "Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study" by Cazzola M, Antivalle M, Sarzi-Puttini P, Dell'Acqua D, Panni B, Caruso I., posted in PubMed
5. Etc.


Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html  

 
References
(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2)   ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(3) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH.(PubMed)
(4) A Comparative Study of Baby Immature and Adult Shoots of Aloe Vera on UVB-Induced Skin Photoaging in vitro. by Hwang E, Kim SH, Lee S, Lee CH, Do SG, Kim J, Kim SY.(PubMed)
(5) Innovations in natural ingredients and their use in skin care.

Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R.(PubMed)
(5) Oral aloe vera-induced hepatitis(PubMed)
(6) Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study(PubMed)