Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Interstitial nephritis (Tubulo-interstitial nephritis)
Interstitial nephritis is defined as a condition of inflammation of the
spaces between renal tubules, affecting the interstitium of the kidneys
and kidney function in wast removal.
Causes and Risk factors
1. In the study of The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis, researchers at the Department of Nephrology, MHH, Hannover, Germany, in determination of risk factors for the development of chronic renal insufficiency, and thus, the transition from acute to chronic interstitial nephritis, showed that acute interstitial nephritis was found in 6.5% of all biopsies (64 patients with 68 episodes of acute interstitial nephritis);
it was infection-induced in 10%, idiopathic in 4%, and drug-induced in
85% of the cases (antibiotics in 13 cases, analgesics in 17,
non-steroidal anti-inflammatory drugs (NSAIDs) in 16, diuretics in 5,
and various other drugs in 7). Renal insufficiency was reversible in 69%
and permanent in 31% (12% partially reversible, 19% irreversible). The
infection-induced and idiopathic types of acute interstitial nephritis were always reversible. Drug-related acute interstitial nephritis
caused permanent renal insufficiency in 36% with a maximum of 56% in
NSAID-induced cases. In drug-induced cases, intake of the suspected drug
for more than a month prior to diagnosis caused permanent renal
insufficiency in 88% and interstitial granuloma in 31%(2).
2. Impaired potassium and magnesium homeostasis and urinary losses are associated with the increased risk of acute tubulo-interstitial nephritis(3)
3. Hypercalcemia is a
life-threatening disorder and is related primarily to neoplastic
diseases and primary and secondary hyperparathyroidism and associated to
the risk of Interstitial nephritis(4).
4. Allergic effect
A severe generalized multisystem allergic reaction occurred in a 16-month-old infant following the use of trimethoprim-sulfamethoxazole. Acute interstitial nephritis
developed three weeks following the onset of this reaction and resolved
after three months. This is the first description of this renal
toxicity with TMP-SMX in a child(4a).
5. Etc.
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Sources
(2) http://www.ncbi.nlm.nih.gov/pubmed/11020015
(3) http://www.ncbi.nlm.nih.gov/pubmed/4058627
(4) http://www.ncbi.nlm.nih.gov/pubmed/19356379
(4a) http://www.ncbi.nlm.nih.gov/pubmed/7149348
Tuesday, 3 December 2013
Nephritis: Interstitial nephritis (Tubulo-interstitial nephritis) - Signs and Symptoms
Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Interstitial nephritis (Tubulo-interstitial nephritis)
Interstitial nephritis is defined as a condition of inflammation of the spaces between renal tubules, affecting the interstitium of the kidneys and kidney function in wast removal.
A. Signs and symptoms
In the study of Symptoms in patients with tubulo-interstitial nephritis, researchers at the School of Medicine, Juntendo University, indicated that in patients with acute TIN, marked
1. Fever,
2. Back or flank pain
3. CVA tenderness
4. Skin rash
5. Arthralgia
6. Cosinophilia and
7. Eosinouria are observed.
Clinical symptoms might be induced by glomerular, proximal tubular or distal tubular dysfunction in chronic TIN. Mild to moderate
8. Proteinuria
9. Edema
10. Hypertension
11. Azotemia
12. Glucosuria
13. Aminoaciduria
14. Polyuria and
15. Polydipsia are characteristic findings in patients with chronic TIN(1).
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/7563629
Interstitial nephritis (Tubulo-interstitial nephritis)
Interstitial nephritis is defined as a condition of inflammation of the spaces between renal tubules, affecting the interstitium of the kidneys and kidney function in wast removal.
A. Signs and symptoms
In the study of Symptoms in patients with tubulo-interstitial nephritis, researchers at the School of Medicine, Juntendo University, indicated that in patients with acute TIN, marked
1. Fever,
2. Back or flank pain
3. CVA tenderness
4. Skin rash
5. Arthralgia
6. Cosinophilia and
7. Eosinouria are observed.
Clinical symptoms might be induced by glomerular, proximal tubular or distal tubular dysfunction in chronic TIN. Mild to moderate
8. Proteinuria
9. Edema
10. Hypertension
11. Azotemia
12. Glucosuria
13. Aminoaciduria
14. Polyuria and
15. Polydipsia are characteristic findings in patients with chronic TIN(1).
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/7563629
Nephritis: Glomerulonephritis Treatment In Traditional Chinese medicine perspective
Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Treatments
In Traditional Chinese medicine perspective
C.1. HTCM herbal formula: Huang Dan decoction (HDD) and Tripterygium Wilfordii (TW)
In the study to investigate the therapeutic effects of huangdan decoction (HDD) and Tripterygium Wilfordii (TW) compound tablet on membranous glomerulonephritis in rats, researchers at the Tongji Medical University, indicated that HDD and TW may alleviate the pathological lesions of MGN, prevent or retard its progression, and have remarkable therapeutic effects on MGN(40).
C.2. Shen Yan Yi Qi Ye
In the study using cationic bovine serum albumin (C-BSA) for duplicating experimental animal model of membranous glomerulonephritis with chronic renal failure, found that in the therapeutic group, the urine protein and serum creatinine were reduced as compared with those in pathological group, P < 0.01. The parameter of morphometric analysis of glomeruli such as mean diameter, mean perimeter, mean surface area, mean volume, mean cross sectional area were all decreased, P < 0.01, the number of glomerular proliferative cells and thickness of glomerular capillary wall were all attenuated, P < 0.01, as compared with those in the pathological group. It suggested that SYYQY might alleviate the glomeruli lesions and benefit the renal functions, according to the study by Beijing University of TCM(41).
C.3. Etc.
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Sources
(40) http://www.ncbi.nlm.nih.gov/pubmed/7783260
(41) http://www.ncbi.nlm.nih.gov/pubmed/7950217
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Treatments
In Traditional Chinese medicine perspective
C.1. HTCM herbal formula: Huang Dan decoction (HDD) and Tripterygium Wilfordii (TW)
In the study to investigate the therapeutic effects of huangdan decoction (HDD) and Tripterygium Wilfordii (TW) compound tablet on membranous glomerulonephritis in rats, researchers at the Tongji Medical University, indicated that HDD and TW may alleviate the pathological lesions of MGN, prevent or retard its progression, and have remarkable therapeutic effects on MGN(40).
C.2. Shen Yan Yi Qi Ye
In the study using cationic bovine serum albumin (C-BSA) for duplicating experimental animal model of membranous glomerulonephritis with chronic renal failure, found that in the therapeutic group, the urine protein and serum creatinine were reduced as compared with those in pathological group, P < 0.01. The parameter of morphometric analysis of glomeruli such as mean diameter, mean perimeter, mean surface area, mean volume, mean cross sectional area were all decreased, P < 0.01, the number of glomerular proliferative cells and thickness of glomerular capillary wall were all attenuated, P < 0.01, as compared with those in the pathological group. It suggested that SYYQY might alleviate the glomeruli lesions and benefit the renal functions, according to the study by Beijing University of TCM(41).
C.3. Etc.
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Sources
(40) http://www.ncbi.nlm.nih.gov/pubmed/7783260
(41) http://www.ncbi.nlm.nih.gov/pubmed/7950217
Nephritis: Glomerulonephritis Treatment In Herbal medicine perspective
Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Treatments
B. In herbal medicine perspective
According to the research of Herbal treatments of glomerulonephritis and chronicrenal failure: Review and recommendations by Rainer Nowack, Felipe Flores-Suarez, Rainer Birck, Wilhelm Schmitt and Urs Benck(34), some herbs below may have certain effects in treating glomerulonephritis.
1. Astragalus
In the study to evaluate the effect of APS on glomerulonephritis rats induced by cationic Bovine Serum Albumin(C-BSA) by flow cytometry using Nuclear Transcription Factor-kappaB (NF-kappaB) as marker, showed that the expression of NF-kappaB and the concentration of IL-2, IL-6 and TNF-alpha were significantly decreased in the treatment group. This study clearly suggests that APS is effective in protecting against glomerulonephritis induced by C-BSA through the inhibition of NF-kappaB mediated-cytokine pathway(35).
2. Rhubarb
In the study of the evidence of the effect of Rhubarb in immune complex GN induced in rats by injection of anti-thymocyte serum (ATS), researchers at the Department of Nephrology, Drum Tower Hospital, indicated that Rhubarb-treated anti-Thy-1 animal model should develop significantly less matrix expansion. Rhubarb also inhibited synthesis and secretion of fibronectin, an important component of mesangial extracellular matrix. Decreased IL-1 activity might be involved in the therapeutic effect of Rhubarb on mesangioproliferative glomerulonephritis(36).
3. Perilla frutescens
In the study to evaluate the anti-nephritic effects of perilla in HIGA mice that spontaneously develop high levels of serum immunoglobulin A (IgA) along with mesangial IgA deposition, researchers at the Graduate School of Pharmaceutical Sciences, Kyoto University, showed that Perilla suppressed proteinuria, proliferation of glomerular cells, serum levels of IgA, glomerular IgA and IgG depositions in HIGA mice. Cultured Peyer's patch cells and spleen cells from perilla-treated mice produced significantly less IgA than controls. Rosmarinic acid, by itself, suppressed serum IgA levels and glomerular IgA deposition in HIGA mice. Cultured spleen cells from RsA-treated mice produced less IgA than controls(37).
4. Dan Shen and Sheng Mai Ye
In the study to investigate the effects of danshen(Salvia plectranthoides Griff.) and shengmaiye (Panax ginseng C. A. Mey, Ophiopogon japonicus Ker-Gawl and Schisandra chinensis Baill) on glomerulosclerosis induced by adriamycin in SD rats, showed that Dansheng and shengmaiye may play an important role in the treatment of glomerulosclerosis in rats(38).
5. Arctium lappa
In the study of the ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats, researchers at the School of Pharmacy, Second Military Medical University, found that the ameliorative effects of arctiin on glomerulonephritis is carried out mainly by suppression of NF-kappaB activation and nuclear translocation and the decreases in the levels of these pro-inflammatory cytokines, while SOD is involved in the inhibitory pathway of NF-kappaB activation. Arctiin has favorable potency for the development of an inhibitory agent of NF-kappaB and further application to clinical treatment of glomerulonephritis, though clinical studies are required(39).
6. Etc.
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Sources
(34) http://www.academicjournals.org/jpp/PDF/Pdf2011/Oct/Nowack%20et%20al.pdf
(35) http://www.ncbi.nlm.nih.gov/pubmed/17161813
(36) http://www.ncbi.nlm.nih.gov/pubmed/9812565
(37) http://www.ncbi.nlm.nih.gov/pubmed/12584268
(38) http://www.ncbi.nlm.nih.gov/pubmed/12080639
(39) http://www.ncbi.nlm.nih.gov/pubmed/19524415
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Treatments
B. In herbal medicine perspective
According to the research of Herbal treatments of glomerulonephritis and chronicrenal failure: Review and recommendations by Rainer Nowack, Felipe Flores-Suarez, Rainer Birck, Wilhelm Schmitt and Urs Benck(34), some herbs below may have certain effects in treating glomerulonephritis.
1. Astragalus
In the study to evaluate the effect of APS on glomerulonephritis rats induced by cationic Bovine Serum Albumin(C-BSA) by flow cytometry using Nuclear Transcription Factor-kappaB (NF-kappaB) as marker, showed that the expression of NF-kappaB and the concentration of IL-2, IL-6 and TNF-alpha were significantly decreased in the treatment group. This study clearly suggests that APS is effective in protecting against glomerulonephritis induced by C-BSA through the inhibition of NF-kappaB mediated-cytokine pathway(35).
2. Rhubarb
In the study of the evidence of the effect of Rhubarb in immune complex GN induced in rats by injection of anti-thymocyte serum (ATS), researchers at the Department of Nephrology, Drum Tower Hospital, indicated that Rhubarb-treated anti-Thy-1 animal model should develop significantly less matrix expansion. Rhubarb also inhibited synthesis and secretion of fibronectin, an important component of mesangial extracellular matrix. Decreased IL-1 activity might be involved in the therapeutic effect of Rhubarb on mesangioproliferative glomerulonephritis(36).
3. Perilla frutescens
In the study to evaluate the anti-nephritic effects of perilla in HIGA mice that spontaneously develop high levels of serum immunoglobulin A (IgA) along with mesangial IgA deposition, researchers at the Graduate School of Pharmaceutical Sciences, Kyoto University, showed that Perilla suppressed proteinuria, proliferation of glomerular cells, serum levels of IgA, glomerular IgA and IgG depositions in HIGA mice. Cultured Peyer's patch cells and spleen cells from perilla-treated mice produced significantly less IgA than controls. Rosmarinic acid, by itself, suppressed serum IgA levels and glomerular IgA deposition in HIGA mice. Cultured spleen cells from RsA-treated mice produced less IgA than controls(37).
4. Dan Shen and Sheng Mai Ye
In the study to investigate the effects of danshen(Salvia plectranthoides Griff.) and shengmaiye (Panax ginseng C. A. Mey, Ophiopogon japonicus Ker-Gawl and Schisandra chinensis Baill) on glomerulosclerosis induced by adriamycin in SD rats, showed that Dansheng and shengmaiye may play an important role in the treatment of glomerulosclerosis in rats(38).
5. Arctium lappa
In the study of the ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats, researchers at the School of Pharmacy, Second Military Medical University, found that the ameliorative effects of arctiin on glomerulonephritis is carried out mainly by suppression of NF-kappaB activation and nuclear translocation and the decreases in the levels of these pro-inflammatory cytokines, while SOD is involved in the inhibitory pathway of NF-kappaB activation. Arctiin has favorable potency for the development of an inhibitory agent of NF-kappaB and further application to clinical treatment of glomerulonephritis, though clinical studies are required(39).
6. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
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Sources
(34) http://www.academicjournals.org/jpp/PDF/Pdf2011/Oct/Nowack%20et%20al.pdf
(35) http://www.ncbi.nlm.nih.gov/pubmed/17161813
(36) http://www.ncbi.nlm.nih.gov/pubmed/9812565
(37) http://www.ncbi.nlm.nih.gov/pubmed/12584268
(38) http://www.ncbi.nlm.nih.gov/pubmed/12080639
(39) http://www.ncbi.nlm.nih.gov/pubmed/19524415
Nephritis: Glomerulonephritis Treatment In conventional medicine perspective
Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Treatment
F.1. In conventional medicine perspective
Treatment depends on the underlined causes, symptom and types of glomerulonephritis (Acute or chronic)
F.1.1. If the causes of the disease is the result of hypertension
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart and staying high over time, damaging the body in many ways.
1. Diuretics
Thiazide diuretics were the first tolerated efficient antihypertensive drugs that significantly reduced cardiovascular morbidity and mortality in placebo-controlled clinical studies. Although these drugs today still are considered a fundamental therapeutic tool for the treatment of hypertensive patients. Thiazide diuretics must be used at appropriate and/or optimal doses to achieve the optimal antihypertensive effect with the smallest occurrence of side effects, including alterations in glucose and lipid profiles and hypokalemia. Moreover, because thiazide diuretics can increase the incidence of new-onset diabetes, especially when combined with beta blockers, caution is advised in using these drugs above all in patients who are at high risk for developing diabetes(29), according to the study by Department of Internal Medicine, University of Pisa(29).
2. Angiotensin-converting enzyme (ACE) inhibitors and Angiotensin II receptor agonists
In the study of a total of 25,035 hypertensive patients newly prescribed an ACE inhibitor or angiotensin II receptor blockers (ARBs), no differences were found in risk of death, coronary disease, chronic kidney disease, or stroke between those prescribed ACE inhibitors and those prescribed ARBs. Patients prescribed ARBs had a greater rate of new-onset diabetes (hazard ratio [HR], 1.28; confidence interval [CI], 1.08-1.52), and this was especially true for women (HR, 1.93; CI, 1.22-3.07). Within a large medical-practice based population, there was no evidence of differential effectiveness between ACE inhibitors and ARBs for most outcomes, with diabetes being the notable exception(30).
3. Etc.
A.2. If the causes of the disease is the result of infection due to invasion of bacteria
Corticosteroid therapy with antibiotics
There is a report of a 24-years old man who presented to the hospital with fever, fatigue, and rapidly progressive glomerulonephritis. Although renal function in the case worsened despite therapy with antibiotics, a short-term and low dose of corticosteroid therapy with antibiotics was able to recover renal function and the patient finally underwent tricuspid valve-plasty and VSD closure, according to the study by Shiga University of Medical Science, Seta(31).
A.3. Lupus or vasculitis
Lupus is a chronic, autoimmune disease as as a result of the development of autoantibodies that attack the systems and organs in the body.researchers at the indicated that saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production. Immune-suppressing drugs can be prescribed to control inflammation.
Immune-suppressing drugs
Tacrolimus, an immune-suppressing drug, at low dosage and serum level to be potentially effective and safe for treatment in patients with LN resistant to sufficient CYC therapy. A tacrolimus dosage of 2-3 mg daily appears to be effective and safe, according to the study by Peking Union Medical College Hospital, Chinese Academy of Medical Sciences(32)
A.4. IgA nephropathy
Treatment strategies have included management of blood pressure and lipids, improvement or stabilization of kidney function, and reduction of proteinuria. Supportive therapies, including angiotensin blockade, should be considered as first-line therapy for patients with urine protein >0.5 g/day and/or blood pressure >140/90 mm Hg. Corticosteroids could be considered as add-on or monotherapy for patients with urine protein >1 g/day with preserved renal function, but conclusive data are lacking for general treatment recommendations for the use of other therapies for IgAN(33).
A.5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
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Sources
(29) http://www.ncbi.nlm.nih.gov/pubmed/16565243
(30) http://www.ncbi.nlm.nih.gov/pubmed/22747612
(31) http://www.ncbi.nlm.nih.gov/pubmed/15610562
(32) http://www.ncbi.nlm.nih.gov/pubmed/22935463
(33) http://www.ncbi.nlm.nih.gov/pubmed/21954446
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Treatment
F.1. In conventional medicine perspective
Treatment depends on the underlined causes, symptom and types of glomerulonephritis (Acute or chronic)
F.1.1. If the causes of the disease is the result of hypertension
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart and staying high over time, damaging the body in many ways.
1. Diuretics
Thiazide diuretics were the first tolerated efficient antihypertensive drugs that significantly reduced cardiovascular morbidity and mortality in placebo-controlled clinical studies. Although these drugs today still are considered a fundamental therapeutic tool for the treatment of hypertensive patients. Thiazide diuretics must be used at appropriate and/or optimal doses to achieve the optimal antihypertensive effect with the smallest occurrence of side effects, including alterations in glucose and lipid profiles and hypokalemia. Moreover, because thiazide diuretics can increase the incidence of new-onset diabetes, especially when combined with beta blockers, caution is advised in using these drugs above all in patients who are at high risk for developing diabetes(29), according to the study by Department of Internal Medicine, University of Pisa(29).
2. Angiotensin-converting enzyme (ACE) inhibitors and Angiotensin II receptor agonists
In the study of a total of 25,035 hypertensive patients newly prescribed an ACE inhibitor or angiotensin II receptor blockers (ARBs), no differences were found in risk of death, coronary disease, chronic kidney disease, or stroke between those prescribed ACE inhibitors and those prescribed ARBs. Patients prescribed ARBs had a greater rate of new-onset diabetes (hazard ratio [HR], 1.28; confidence interval [CI], 1.08-1.52), and this was especially true for women (HR, 1.93; CI, 1.22-3.07). Within a large medical-practice based population, there was no evidence of differential effectiveness between ACE inhibitors and ARBs for most outcomes, with diabetes being the notable exception(30).
3. Etc.
A.2. If the causes of the disease is the result of infection due to invasion of bacteria
Corticosteroid therapy with antibiotics
There is a report of a 24-years old man who presented to the hospital with fever, fatigue, and rapidly progressive glomerulonephritis. Although renal function in the case worsened despite therapy with antibiotics, a short-term and low dose of corticosteroid therapy with antibiotics was able to recover renal function and the patient finally underwent tricuspid valve-plasty and VSD closure, according to the study by Shiga University of Medical Science, Seta(31).
A.3. Lupus or vasculitis
Lupus is a chronic, autoimmune disease as as a result of the development of autoantibodies that attack the systems and organs in the body.researchers at the indicated that saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production. Immune-suppressing drugs can be prescribed to control inflammation.
Immune-suppressing drugs
Tacrolimus, an immune-suppressing drug, at low dosage and serum level to be potentially effective and safe for treatment in patients with LN resistant to sufficient CYC therapy. A tacrolimus dosage of 2-3 mg daily appears to be effective and safe, according to the study by Peking Union Medical College Hospital, Chinese Academy of Medical Sciences(32)
A.4. IgA nephropathy
Treatment strategies have included management of blood pressure and lipids, improvement or stabilization of kidney function, and reduction of proteinuria. Supportive therapies, including angiotensin blockade, should be considered as first-line therapy for patients with urine protein >0.5 g/day and/or blood pressure >140/90 mm Hg. Corticosteroids could be considered as add-on or monotherapy for patients with urine protein >1 g/day with preserved renal function, but conclusive data are lacking for general treatment recommendations for the use of other therapies for IgAN(33).
A.5. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
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Sources
(29) http://www.ncbi.nlm.nih.gov/pubmed/16565243
(30) http://www.ncbi.nlm.nih.gov/pubmed/22747612
(31) http://www.ncbi.nlm.nih.gov/pubmed/15610562
(32) http://www.ncbi.nlm.nih.gov/pubmed/22935463
(33) http://www.ncbi.nlm.nih.gov/pubmed/21954446
Nephritis: Glomerulonephritis Prevention - The Diet
Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Diet to prevent Glomerulonephritis
1. Flaxseed
In the study to evaluate Flaxseed: a potential treatment for lupus nephritis, showed that 30 g flaxseed/day was well tolerated and conferred benefit in terms of renal function as well as inflammatory and atherogenic mechanisms important in the pathogenesis of lupus nephritis(26).
2. Green tea
In the study to investigate whether the anti-inflammatory and antioxidant properties of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) favorably affect the development of immune-mediated GN, researchers at the Shanghai Tenth People's Hospital of Tongji University, found that levels of glutathione peroxidase and peroxisome proliferator-activated receptor-γ (PPARγ), both reduced in the vehicle-pretreated diseased mice, were normalized. This renoprotective effect was reversed by concomitant administration of the PPARγ antagonist GW9662 throughout the EGCG pretreatment period. Importantly, mortality and renal dysfunction were significantly attenuated even when the polyphenol treatment was initiated 1 week after the onset of GN. Thus, EGCG reversed the progression of immune-mediated GN in mice by targeting redox and inflammatory pathways(27).
3. Organic Soy
According to the study of Beneficial effects of soy protein consumption for renal function by Anderson JW. at the University of Kentucky, substituting soy protein for animal protein usually decreases hyperfiltration in diabetic subjects and may reduce urine albumin excretion. Limited data are available on effects of soy peptides, isoflavones, and other soy components on renal function on renal function in diabetes(28).
4. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(25) http://www.ncbi.nlm.nih.gov/pubmed/11942476
(26) http://www.ncbi.nlm.nih.gov/pubmed/7564115
(27) http://www.ncbi.nlm.nih.gov/pubmed/21544063
(28) http://www.ncbi.nlm.nih.gov/pubmed/18296369
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Diet to prevent Glomerulonephritis
1. Flaxseed
In the study to evaluate Flaxseed: a potential treatment for lupus nephritis, showed that 30 g flaxseed/day was well tolerated and conferred benefit in terms of renal function as well as inflammatory and atherogenic mechanisms important in the pathogenesis of lupus nephritis(26).
2. Green tea
In the study to investigate whether the anti-inflammatory and antioxidant properties of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) favorably affect the development of immune-mediated GN, researchers at the Shanghai Tenth People's Hospital of Tongji University, found that levels of glutathione peroxidase and peroxisome proliferator-activated receptor-γ (PPARγ), both reduced in the vehicle-pretreated diseased mice, were normalized. This renoprotective effect was reversed by concomitant administration of the PPARγ antagonist GW9662 throughout the EGCG pretreatment period. Importantly, mortality and renal dysfunction were significantly attenuated even when the polyphenol treatment was initiated 1 week after the onset of GN. Thus, EGCG reversed the progression of immune-mediated GN in mice by targeting redox and inflammatory pathways(27).
3. Organic Soy
According to the study of Beneficial effects of soy protein consumption for renal function by Anderson JW. at the University of Kentucky, substituting soy protein for animal protein usually decreases hyperfiltration in diabetic subjects and may reduce urine albumin excretion. Limited data are available on effects of soy peptides, isoflavones, and other soy components on renal function on renal function in diabetes(28).
4. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
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Sources
(25) http://www.ncbi.nlm.nih.gov/pubmed/11942476
(26) http://www.ncbi.nlm.nih.gov/pubmed/7564115
(27) http://www.ncbi.nlm.nih.gov/pubmed/21544063
(28) http://www.ncbi.nlm.nih.gov/pubmed/18296369
Nephritis: Glomerulonephritis Prevention - The Phytochemicals
Nephritis is defined as a condition of inflammation of the nephrons in the kidneys.
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Phytochemicals to prevent glomerulonephritis
1. (-)-epigallocatechin-3-gallate (EGCG)
In the study of Glomerulonephritis therapy: is there a role for green tea?, researchers at the Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, showed that (-)-epigallocatechin-3-gallate (EGCG) treatment ameliorates renal inflammation, tissue damage, and loss of renal function and might therefore represent a novel therapeutic approach for human glomerulonephritis(23).
2. Resveratrol
Mesangioproliferative glomerulonephritis is associated with overactive PDGF receptor signal transduction. We show that the phytoalexin resveratrol dose dependently inhibits PDGF-induced DNA synthesis in mesangial cells with an IC(50) of 10 microM without inducing apoptosis(24).
3. Isoflavones genistein and genistin
In the study to evaluate the Male Wistar rats with glomerulonephritis caused by a single intravenous injection of nephrotoxic serum,with 5 mg of genistein or 8 mg of genistin/d/100 g body weight for 12 d given orrally, found that these isoflavones suppressed nephritis-induced severe hypercholesterolemia and hypertriglyceridemia, and their hypolipidemic action was almost identical. Fecal steroid excretion was unchanged by administration of the two isoflavones. Genistein inhibited the incorporation of [1-14C]acetate into cholesterol and FA in liver slices from nephritic rats when added to an incubation buffer, whereas genistin did not(25).
4. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(23) http://www.ncbi.nlm.nih.gov/pubmed/21878951
(24) http://www.ncbi.nlm.nih.gov/pubmed/18567737
(25) http://www.ncbi.nlm.nih.gov/pubmed/11942476
Glomerulonephritis is defined as the condition of inflammation of the tiny filters in kidneys (glomeruli), which filter blood by removing excess fluid, electrolytes and waste and pass them through urination.
Phytochemicals to prevent glomerulonephritis
1. (-)-epigallocatechin-3-gallate (EGCG)
In the study of Glomerulonephritis therapy: is there a role for green tea?, researchers at the Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, showed that (-)-epigallocatechin-3-gallate (EGCG) treatment ameliorates renal inflammation, tissue damage, and loss of renal function and might therefore represent a novel therapeutic approach for human glomerulonephritis(23).
2. Resveratrol
Mesangioproliferative glomerulonephritis is associated with overactive PDGF receptor signal transduction. We show that the phytoalexin resveratrol dose dependently inhibits PDGF-induced DNA synthesis in mesangial cells with an IC(50) of 10 microM without inducing apoptosis(24).
3. Isoflavones genistein and genistin
In the study to evaluate the Male Wistar rats with glomerulonephritis caused by a single intravenous injection of nephrotoxic serum,with 5 mg of genistein or 8 mg of genistin/d/100 g body weight for 12 d given orrally, found that these isoflavones suppressed nephritis-induced severe hypercholesterolemia and hypertriglyceridemia, and their hypolipidemic action was almost identical. Fecal steroid excretion was unchanged by administration of the two isoflavones. Genistein inhibited the incorporation of [1-14C]acetate into cholesterol and FA in liver slices from nephritic rats when added to an incubation buffer, whereas genistin did not(25).
4. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to General health http://kylejnorton.blogspot.ca/p/general-health.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(23) http://www.ncbi.nlm.nih.gov/pubmed/21878951
(24) http://www.ncbi.nlm.nih.gov/pubmed/18567737
(25) http://www.ncbi.nlm.nih.gov/pubmed/11942476
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