Cryptoxanthin is a
phytochemincal of Yellow pigments in the class of Xanthophylls ,
belonging to the group of Carotenoids (tetraterpenoids), found
abundantly in orange, papaya, peaches, avocado, pea, grapefruit, kiwi, etc.
Health Benefits
1. Antioxidant effects
In the investigation of the biological properties of beta-cryptoxanthin,
a common carotenoid, in cell culture model systems, using the comet
assay to measure DNA damage, found that At low concentrations, close to
those found in plasma, beta-cryptoxanthin
does not itself cause damage, but protects transformed human cells
(HeLa and Caco-2) from damage induced by H(2)O(2) or by visible light in
the presence of a photosensitizer. In addition, it has a striking
effect on DNA repair, measured in different ways. Incubation of
H(2)O(2)-treated cells with beta-cryptoxanthin
led to a doubling of the rate of rejoining of strand breaks and had a
similar effect on the rate of removal of oxidized purines by base
excision repair, according to "The carotenoid beta-cryptoxanthin stimulates the repair of DNA oxidation damage in addition to acting as an antioxidant in human cells" by Lorenzo Y, Azqueta A, Luna L, Bonilla F, Domínguez G, Collins AR.(1)
2. Anti cancers
In
the demonstration of CHRP and/or MJs (a pulp (CHRP) and citrus juices
(MJ2 and MJ5) from a satsuma mandarin (Citrus unshiu Mar.) juice (MJ))
and theirs effects on rat colon, rat tongue, and mouse lung
tumorigenesis,m found that gavage with CHRP resulted in an increase of
activities of detoxifying enzymes in the liver, colon, and tongue
rats'. CHRP and MJs were also able to suppress the expression of
proinflammatory cytokines and inflammatory enzymes in the target
tissues. This paper describes the findings of our in vivo preclinical
experiments to develop a strategy for cancer chemoprevention of colon,
tongue, and lung neoplasms by use of CHRP and MJs, according to "Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin" by Tanaka T, Tanaka T, Tanaka M, Kuno T.(2)
3. Pulmonary tumorigenesis
In the investigation of the inhibitory effect of mandarin juice rich in beta-cryptoxanthin
and hesperidin on lung cancer, found that treatments with MJ, MJ2, and
MJ5 reduced the incidence of lung tumors and the inhibition by MJ5 (29%
reduction) was statistically significant (P<0.05). MJs treatment
lowered the multiplicity of lung neoplasms without statistical
significance. Immunohistochemically, MJs, especially MJ5, reduced
proliferating cell nuclear antigen (PCNA)-positive index in the lung
tumors without affecting PCNA index in hyperplastic alveolar cell
lesions, according to "Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice" by Kohno H, Taima M, Sumida T, Azuma Y, Ogawa H, Tanaka T.(3)
4. Renal cell carcinoma
In
the assessment of the association between renal cell cancer (RCC) and
intake of fruit, vegetables and nutrients examined in a
population-based case-control study of 323 cases and 1827 controls;
dietary intake was obtained using a mailed questionnaire, found that
β-Cryptoxanthin
and lycopene were also associated with decreased risks, but when both
were included in a mutually adjusted backwards stepwise regression
model, only β-cryptoxanthin
remained significant (OR 0·5; 95 % CI 0·3, 0·8). When other
micronutrients and types of fibre were investigated together, only
vegetable fibre and β-cryptoxanthin had significant trends (P < 0·01) (OR 0·6; 95 % CI 0·3, 0·9) (OR 0·5; 95 % CI 0·3, 0·9), respectively, according to "Fruit, vegetables, fibre and micronutrients and risk of US renal cell carcinoma" by Brock KE, Ke L, Gridley G, Chiu BC, Ershow AG, Lynch CF, Graubard BI, Cantor KP.(4)
5. Adiposity
In
the identification of Oral administration of β-CRX and the effect on
the mechanism, obese model mouse, TSOD used in the study, found that
DNA microarray analysis strongly indicates that the oral administration
of β-CRX represses the inflammatory cytokine secretion and improves the
lipid metabolism and the energy consumption. It also suggests these
effects are partly mediated by PPAR-α, not only lipid metabolism and
adipocyte differentiation control but possibly internal circadian clock
modulation, according to "Prevention of Adiposity by the Oral Administration of β-Cryptoxanthin" by Takayanagi K.(5)
6. Non-Hodgkin lymphoma (NHL)
In
the evaluation of the potential association between consumption of
fruit and vegetables and non-Hodgkin lymphoma (NHL) by histologic,
indicated that for nutrients, the risk of NHL overall was inversely
associated with a higher intake of β-cryptoxanthin
(OR = 0.6; CI = 0.4-0.9), magnesium (OR = 0.4; CI = 0.2-0.6),
potassium (OR = 0.5; CI = 0.3-1.0), and fiber (OR = 0.6; CI = 0.3-1.0),
but positively associated with a higher intake of retinol (OR = 1.7;
CI = 1.1-2.8). Intakes of vitamin E, magnesium, and potassium were
inversely associated with the risk of DLBCL, according to "Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma" by Chiu BC, Kwon S, Evens AM, Surawicz T, Smith SM, Weisenburger DD.(6)
7. Anti lung inflammation, oxidative damage, and squamous metaplasia
In the evaluation of the effects of β-cryptoxanthin
supplementation on cigarette smoke-induced squamous metaplasia,
inflammation, and changes in protein levels of proinflammatory cytokine
[tumor necrosis factor alpha (TNFα)] and transcription factors [nuclear
factor kappa B (NF-κB) and activator protein-1 (AP-1)], as well as on
smoke-induced oxidative DNA damage [8-hydroxy-2'-deoxyguanosine
(8-OHdG)] in the lung tissue of ferrets, found that β-Cryptoxanthin supplementation dose-dependently increased plasma and lung β-cryptoxanthin levels in ferrets, whereas cigarette smoke exposure lowered plasma and lung β-cryptoxanthin levels. β-Cryptoxanthin at both doses significantly decreased smoke-induced lung squamous metaplasia and inflammation. β-Cryptoxanthin
also substantially reduced smoke-elevated TNFα levels in alveolar,
bronchial, bronchiolar, and bronchial serous/mucous gland epithelial
cells and in lung macrophages. Moreover, β-cryptoxanthin decreased smoke-induced activation of NF-κB, expression of AP-1 and levels of 8-OHdG. The beneficial effects of β-cryptoxanthin were stronger for high-dose β-cryptoxanthin than for low-dose β-cryptoxanthin, according to "β-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage, and squamous metaplasia in ferrets" by Liu C, Bronson RT, Russell RM, Wang XD.(7)
8. Insulin resistance
In
the investigation of a fat-soluble extract from persimmon peel (PP)
and fed type 2 diabetic Goto-Kakizaki (GK) rats an AIN-93G rodent diet
supplemented with persimmon peel extract (PP diet) for 12 weeks, found
that compared with the control AIN-93G diet, the PP diet significantly
reduced plasma glutamic-pyruvate transaminase activity, with
accumulation of β-cryptoxanthin
in the liver. DNA microarray analysis revealed that the PP diet
altered hepatic gene expression profiles. In particular, expression of
insulin signaling pathway-related genes was significantly enriched in
differentially expressed gene sets. Moreover, Western blotting analysis
showed an increase in insulin receptor beta tyrosine phosphorylation in
rats fed the PP diet, according to "Hepatic
gene expression of the insulin signaling pathway is altered by
administration of persimmon peel extract: a DNA microarray study using
type 2 diabetic Goto-Kakizaki rats" by Izuchi R, Nakai Y, Takahashi H, Ushiama S, Okada S, Misaka T, Abe K.(8)
9. Anti Breast cancer
In
the study consisting of 604 breast cancer cases and 626 controls with
prospectively measured circulating carotenoid levels and mammographic
density in the Nurses' Health Study,
found that no evidence that
circulating carotenoids are inversely associated with mammographic
density. However, mammographic density significantly modified the
association between total circulating carotenoids and breast cancer (P
heterogeneity = 0.008). Overall, circulating total carotenoids were
inversely associated with breast cancer risk (P trend = 0.01). Among
women in the highest tertile of mammographic density, total carotenoids
were associated with a 50% reduction in breast cancer risk (odds
ratio, 0.5; 95% confidence interval, 0.3-0.8). In contrast, there was
no inverse association between carotenoids and breast cancer risk among
women with low mammographic density. Similarly, among women in the
highest tertile of mammographic density, high levels of circulating
alpha-carotene, beta-cryptoxanthin,
lycopene, and lutein/zeaxanthin were associated with a significant 40%
to 50% reduction in breast cancer risk (P trend < 0.05), according
to "Circulating carotenoids, mammographic density, and subsequent risk of breast cancer" by Tamimi RM, Colditz GA, Hankinson SE.(9)
10. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19056931
(2) http://www.ncbi.nlm.nih.gov/pubmed/22174562
(3) http://www.ncbi.nlm.nih.gov/pubmed/11689289
(4) http://www.ncbi.nlm.nih.gov/pubmed/22186835
(5) http://www.ncbi.nlm.nih.gov/pubmed/22131983
(6) http://www.ncbi.nlm.nih.gov/pubmed/21695384
(7) http://www.ncbi.nlm.nih.gov/pubmed/21421799
(8) http://www.ncbi.nlm.nih.gov/pubmed/21370910
(9) http://www.ncbi.nlm.nih.gov/pubmed/19934322
Sunday, 3 November 2013
Phytochemicals in Foods - 9 Health Benefits of Perillyl alcohol
Perillyl alcohol is a phytochemicals in the class of Monoterpenes, found abundantly in citrus oils, caraway, mints, etc.
Health Benefits
1. Breast cancer
In the searching the effective way in treating breast cancer by investigating the activity of a combination of perillyl alcohol (POH), methyl jasmonate (MJ) with cisplatin, found that Combination treatment of POH and MJ blocked cells at the G0/G1 phase of the cell cycle and the addition of cisplatin forced the cells to progress through the cell cycle and induced apoptosis. Apoptotic mechanistic studies indicated that POH and MJ treatment activated tumor necrosis factor receptor 1 and this was further increased by the addition of cisplatin. It was also found that mitochondrial membrane potential decreased with POH and MJ treatment; this effect was further enhanced by cisplatin treatment, according to "Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin" by Yeruva L, Hall C, Elegbede JA, Carper SW.(1)
2. Pancreatic cancer
In the development of enhanced single or combinatorial therapies to decrease the pathogenesis of this invariably fatal disease. Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a potent cancer gene therapeutic because of its broad-spectrum cancer-specific apoptosis-inducing properties as well as its multipronged indirect antitumor activities,
found that a dietary agent perillyl alcohol (POH) in combination with Ad.mda-7 efficiently reverses the mda-7/IL-24 "protein translational block" by inducing reactive oxygen species, thereby resulting in mda-7/IL-24 protein production, growth suppression, and apoptosis. Pharmacologic inhibitor and small interfering RNA studies identify xanthine oxidase as a major source of superoxide radical production causing these toxic effects, according to " Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol" by Lebedeva IV, Su ZZ, Vozhilla N, Chatman L, Sarkar D, Dent P, Athar M, Fisher PB.(2)
3. Skin cancer
in the evaluation of preparation and characterization ofa novel poly-lactic glycolic acid (PLGA)-based microparticle formulation of perillyl alcohol (POH) and its efficacy against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice, found that in vitro efficacy of POH-bearing PLGA microparticles was evaluated by examining their differential cytotoxicity and assessing their ability to inhibit epidermoid carcinoma cell line (A253). The POH-based microparticles when administered to tumor-bearing animals caused greater tumor regression and increased survival rate (∼80%) as compared with the group receiving free form of POH (survival rate 40%), according to "Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles" by Farazuddin M, Sharma B, Khan AA, Joshi B, Owais M.(3)
4. Lipid Membranes
In the assessment of the possible biophysical effects of these compounds on membranes quantitatively, the influence of limonene and its bio-oxidation products on a membrane model composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) using differential scanning calorimetry (DSC), isothermal titration calorimetry (ITC), and electron paramagnetic resonance spectroscopy (EPR), found that limonene (1), perillyl alcohol (2), and perillaldehyde (3) partitioned into the DMPC membrane, whereas perillic acid (4) did not. The DSC results demonstrated that all the partitioning compounds strongly perturbed the phase transition of DMPC, whereas no perturbation of the local membrane order was detected by EPR spectroscopy, according to "Influence of the Active Compounds of Perilla frutescens Leaves on Lipid Membranes" by Duelund L, Amiot A, Fillon A, Mouritsen OG.(4)
5. Antioxidant and antiproliferative effects
In the investigation of antioxidant potential of three monoterpenoids (carvone, perillyl alcohol, and α-terpineol), using two methods: DPPH and ORAC and the antiproliferative effect of these monoterpenoids against nine cancerous cell lines performed and compared to limonene and doxorubicin, found that all samples tested had very low antioxidant activity in the DPPH assay, but α-terpineol (2.72μmolTrolox equiv./μmol) could be compared to commercial antioxidants in the ORAC assay. The antiproliferative results obtained encourage future in vivo studies for α-terpineol, since this monoterpenoid presented cytostatic effect against six cell lines, especially for breast adenocarcinoma and chronic myeloid leukemia, in a range of 181-588μM, according to "Evaluation of the antioxidant and antiproliferative potential of bioflavors" by Bicas JL, Neri-Numa IA, Ruiz AL, De Carvalho JE, Pastore GM.(5)
6. Transplant coronary artery disease TCAD prevention
In the study of whether systematical dissection of the prenylation pathway to better define the mechanism behind statin inhibition in chronic allograft rejection in heart transplants, or transplant coronary artery disease (TCAD), found that FPT and GGPT-2 (inhibition) are the key enzymes in the HGM-CoA reductase pathway and most influential in TCAD prevention. TCAD reduction is most closely related to smooth muscle cell migration, but not its anti-inflammatory properties, according to "Prevention of transplant coronary artery disease by prenylation inhibitors" by Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP.(6)
7. Oxidative stress
In the investigation of the protective effects of perillyl alcohol (POH) on ethanol-induced acute liver injury in Wistar rats and its probable mechanism, ethanol administration decreased hepatic reduced glutathione content and various antioxidant enzymes activity. TNF-α production and NFκ-B activation was also found to be increased after ethanol administration. POH pre-treatment significantly ameliorates ethanol induced acute liver injury possibly by inhibition of lipid peroxidation, replenishment of endogenous enzymatic and non-enzymatic defense system, downregulation of TNF-α as well as NFκ-B, according to "Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production" by Khan AQ, Nafees S, Sultana S.(7)
8. Non small cell lung cancer
In the investigation of the effects of perillyl alcohol (POH) and its metabolite perillic acid (PA) on the proliferation of non small cell lung cancer (NSCLC, A549, and H520) cells, found that exposing the cells to an IC50 concentration of POH or PA sensitized the cells to cisplatin and radiation in a dose-dependent manner. These results indicate that POH and PA in combination therapy may have chemotherapeutic value against NSCLC, according to "Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells" by Yeruva L, Pierre KJ, Elegbede A, Wang RC, Carper SW.(8)
9. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19820395
(2) http://www.ncbi.nlm.nih.gov/pubmed/18768668
(3) http://www.ncbi.nlm.nih.gov/pubmed/22275821
(4) http://www.ncbi.nlm.nih.gov/pubmed/22272932
(5) http://www.ncbi.nlm.nih.gov/pubmed/21540069
(6) http://www.ncbi.nlm.nih.gov/pubmed/21458297
(7) http://www.ncbi.nlm.nih.gov/pubmed/20923693
(8) http://www.ncbi.nlm.nih.gov/pubmed/17888568
Health Benefits
1. Breast cancer
In the searching the effective way in treating breast cancer by investigating the activity of a combination of perillyl alcohol (POH), methyl jasmonate (MJ) with cisplatin, found that Combination treatment of POH and MJ blocked cells at the G0/G1 phase of the cell cycle and the addition of cisplatin forced the cells to progress through the cell cycle and induced apoptosis. Apoptotic mechanistic studies indicated that POH and MJ treatment activated tumor necrosis factor receptor 1 and this was further increased by the addition of cisplatin. It was also found that mitochondrial membrane potential decreased with POH and MJ treatment; this effect was further enhanced by cisplatin treatment, according to "Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin" by Yeruva L, Hall C, Elegbede JA, Carper SW.(1)
2. Pancreatic cancer
In the development of enhanced single or combinatorial therapies to decrease the pathogenesis of this invariably fatal disease. Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a potent cancer gene therapeutic because of its broad-spectrum cancer-specific apoptosis-inducing properties as well as its multipronged indirect antitumor activities,
found that a dietary agent perillyl alcohol (POH) in combination with Ad.mda-7 efficiently reverses the mda-7/IL-24 "protein translational block" by inducing reactive oxygen species, thereby resulting in mda-7/IL-24 protein production, growth suppression, and apoptosis. Pharmacologic inhibitor and small interfering RNA studies identify xanthine oxidase as a major source of superoxide radical production causing these toxic effects, according to " Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol" by Lebedeva IV, Su ZZ, Vozhilla N, Chatman L, Sarkar D, Dent P, Athar M, Fisher PB.(2)
3. Skin cancer
in the evaluation of preparation and characterization ofa novel poly-lactic glycolic acid (PLGA)-based microparticle formulation of perillyl alcohol (POH) and its efficacy against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice, found that in vitro efficacy of POH-bearing PLGA microparticles was evaluated by examining their differential cytotoxicity and assessing their ability to inhibit epidermoid carcinoma cell line (A253). The POH-based microparticles when administered to tumor-bearing animals caused greater tumor regression and increased survival rate (∼80%) as compared with the group receiving free form of POH (survival rate 40%), according to "Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles" by Farazuddin M, Sharma B, Khan AA, Joshi B, Owais M.(3)
4. Lipid Membranes
In the assessment of the possible biophysical effects of these compounds on membranes quantitatively, the influence of limonene and its bio-oxidation products on a membrane model composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) using differential scanning calorimetry (DSC), isothermal titration calorimetry (ITC), and electron paramagnetic resonance spectroscopy (EPR), found that limonene (1), perillyl alcohol (2), and perillaldehyde (3) partitioned into the DMPC membrane, whereas perillic acid (4) did not. The DSC results demonstrated that all the partitioning compounds strongly perturbed the phase transition of DMPC, whereas no perturbation of the local membrane order was detected by EPR spectroscopy, according to "Influence of the Active Compounds of Perilla frutescens Leaves on Lipid Membranes" by Duelund L, Amiot A, Fillon A, Mouritsen OG.(4)
5. Antioxidant and antiproliferative effects
In the investigation of antioxidant potential of three monoterpenoids (carvone, perillyl alcohol, and α-terpineol), using two methods: DPPH and ORAC and the antiproliferative effect of these monoterpenoids against nine cancerous cell lines performed and compared to limonene and doxorubicin, found that all samples tested had very low antioxidant activity in the DPPH assay, but α-terpineol (2.72μmolTrolox equiv./μmol) could be compared to commercial antioxidants in the ORAC assay. The antiproliferative results obtained encourage future in vivo studies for α-terpineol, since this monoterpenoid presented cytostatic effect against six cell lines, especially for breast adenocarcinoma and chronic myeloid leukemia, in a range of 181-588μM, according to "Evaluation of the antioxidant and antiproliferative potential of bioflavors" by Bicas JL, Neri-Numa IA, Ruiz AL, De Carvalho JE, Pastore GM.(5)
6. Transplant coronary artery disease TCAD prevention
In the study of whether systematical dissection of the prenylation pathway to better define the mechanism behind statin inhibition in chronic allograft rejection in heart transplants, or transplant coronary artery disease (TCAD), found that FPT and GGPT-2 (inhibition) are the key enzymes in the HGM-CoA reductase pathway and most influential in TCAD prevention. TCAD reduction is most closely related to smooth muscle cell migration, but not its anti-inflammatory properties, according to "Prevention of transplant coronary artery disease by prenylation inhibitors" by Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP.(6)
7. Oxidative stress
In the investigation of the protective effects of perillyl alcohol (POH) on ethanol-induced acute liver injury in Wistar rats and its probable mechanism, ethanol administration decreased hepatic reduced glutathione content and various antioxidant enzymes activity. TNF-α production and NFκ-B activation was also found to be increased after ethanol administration. POH pre-treatment significantly ameliorates ethanol induced acute liver injury possibly by inhibition of lipid peroxidation, replenishment of endogenous enzymatic and non-enzymatic defense system, downregulation of TNF-α as well as NFκ-B, according to "Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production" by Khan AQ, Nafees S, Sultana S.(7)
8. Non small cell lung cancer
In the investigation of the effects of perillyl alcohol (POH) and its metabolite perillic acid (PA) on the proliferation of non small cell lung cancer (NSCLC, A549, and H520) cells, found that exposing the cells to an IC50 concentration of POH or PA sensitized the cells to cisplatin and radiation in a dose-dependent manner. These results indicate that POH and PA in combination therapy may have chemotherapeutic value against NSCLC, according to "Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells" by Yeruva L, Pierre KJ, Elegbede A, Wang RC, Carper SW.(8)
9. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19820395
(2) http://www.ncbi.nlm.nih.gov/pubmed/18768668
(3) http://www.ncbi.nlm.nih.gov/pubmed/22275821
(4) http://www.ncbi.nlm.nih.gov/pubmed/22272932
(5) http://www.ncbi.nlm.nih.gov/pubmed/21540069
(6) http://www.ncbi.nlm.nih.gov/pubmed/21458297
(7) http://www.ncbi.nlm.nih.gov/pubmed/20923693
(8) http://www.ncbi.nlm.nih.gov/pubmed/17888568
Chinese Herbs – Sang Ji Sheng (Ramulus Loranthi)
Sang Ji Sheng is also known as mulberry
mistletoes. The bitter and neutral herb has been used in TCM as
diuretic, lowering blood pressure, sedative, antiviral agent and to
dilate coronary arteries, improve volume of circulation, etc., as it
expels Wind-Damp, tonifies the Liver andthe Kidney, strengthens the
sinews and bone, prevents miscarriage, etc. by enhancing the functions
liver and kidney channels.
Ingredients
1. Quercetin
2. Avicularin
3. Triterpenes
4. Oleanolic acid
5. Flavonoids
6. (+)-catechin; Rutin; Isoquercitrin
7. 7-O-galloyl-(+)-catechin; Quercetin-3-O-(6″-galloyl)-(-D-glucoside
8. Quercetin-3-O-(6″-galloyl)-(-D-galactoside
9. Quercetin-3-O-(-D-glucuronide
10. Etc.
Health Benefits
1. Fatty acid synthase (EC 2.3.1.85, FAS) inhibition and body weight reduction
In the study to determine the inhibitory characteristics and kinetic parameters of extracts of parasitic loranthus [Taxillus chinensis (DC.) Danser]. The parasitic loranthus extracts (PLE) inhibits FAS reversibly and irreversibly and with an IC50 value of 0.48 microg/ml, appears to be the most potent inhibitor reported to date. PLE contains various potent inhibitors and may react with different sites on FAS. The irreversible inhibition exhibits a time-dependent biphasic process including a speedy fast-phase during the initial several minutes. The fast-phase inhibition seems to be caused by some potent but low-concentration component(s) in the extracts(1)
2. Refractory polycystic ovary syndrome (PCOS)
In the clinical effect of traditional Chinese medicine Bushen Houxue (BSHX)(dodder seed 20 g, prepared rehmannia root 10 g, mulberry mistletoe 20 g, epimedium 15 g, psoralea fruit 10 g, solomonseal rhizome 10 g, honeylocust thorn 15 g, peach kernel 10 g, pleione bulbocodioides 10 g, red sage root 20 g, and licorice root 6 g,) method combined with ultrasound-guided follicle aspiration (MFA) in treating refractory polycystic ovary syndrome (PCOS) found that BSHX method combined with MFA is a safe and effective treatment for refractory PCOS, with few trauma. The combined usage of Chinese herbal medicine could significantly reduce dosage of HMG used for promoting follicle and the production of multiple mature follicles, thus to avoid the risk of ovarian hyperstimulating syndrome (OHSS)(2).
3. Anticancer effects
In the study to compare the anticancer effects of flavonoids extracts of Scurrula parasitica from different host trees in vitro. 80% ethanol extracts of S. parasitica parasitizing on Nernium indicum, Morus alba, Opsmanthus fragrans, and Sapindus mulorossi were purified by polyamides column chromatography, and the eluates of 30%, 50%, 70% and 90% ethanol were mixed as flavonoids extracts. Extract of S. parasitica parasitizing on N. indicum (NISPEX) was the most sensitive to HL-60 cells of the 4 different host trees, the IC50 value being 0.60 mg x L(-1); and extract of S. parasitica parasitizing on M. alba took the second place, the IC50 value, being 2.49 mg x L(-1); extract of S. parasitica parasitizing on O. fragrans had no effectiveness as high as 50 mg x L(-1) concentration. NISPEX induced HL-60 cell apoptosis and inhibited the cell proliferation in dose and time-dependent manner. Cell cycles were arrested at G0-G1 phase after treated with NISPEX(3).
4. Diabetes
In the study of the Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats, showed that Tapinanthus nyasicus leaf, Ficus thoningii bark, Solanum incanum fruit, and Morus alba leaf extracts decreased weekly food consumption throughout the 5-week study period. Similar results were obtained for the groups treated with metformin or glibenclamide. However, food consumption was increased by S. incanum root, Aloe chabaudii leaf, or Allium sativum bulb extracts, and this was associated with high prevalence of diarrhea(4).
5. Etc.
Side Effects
1. Overdose can cause vomiting, diarrhea, etc.
2. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed?term=%09Taxillus%20chinensis%20%28DC.%29%20Danser.
(2) http://www.ncbi.nlm.nih.gov/pubmed/18543483
(3) http://www.ncbi.nlm.nih.gov/pubmed/18533504
(4) http://www.ncbi.nlm.nih.gov/pubmed/16801983
Ingredients
1. Quercetin
2. Avicularin
3. Triterpenes
4. Oleanolic acid
5. Flavonoids
6. (+)-catechin; Rutin; Isoquercitrin
7. 7-O-galloyl-(+)-catechin; Quercetin-3-O-(6″-galloyl)-(-D-glucoside
8. Quercetin-3-O-(6″-galloyl)-(-D-galactoside
9. Quercetin-3-O-(-D-glucuronide
10. Etc.
Health Benefits
1. Fatty acid synthase (EC 2.3.1.85, FAS) inhibition and body weight reduction
In the study to determine the inhibitory characteristics and kinetic parameters of extracts of parasitic loranthus [Taxillus chinensis (DC.) Danser]. The parasitic loranthus extracts (PLE) inhibits FAS reversibly and irreversibly and with an IC50 value of 0.48 microg/ml, appears to be the most potent inhibitor reported to date. PLE contains various potent inhibitors and may react with different sites on FAS. The irreversible inhibition exhibits a time-dependent biphasic process including a speedy fast-phase during the initial several minutes. The fast-phase inhibition seems to be caused by some potent but low-concentration component(s) in the extracts(1)
2. Refractory polycystic ovary syndrome (PCOS)
In the clinical effect of traditional Chinese medicine Bushen Houxue (BSHX)(dodder seed 20 g, prepared rehmannia root 10 g, mulberry mistletoe 20 g, epimedium 15 g, psoralea fruit 10 g, solomonseal rhizome 10 g, honeylocust thorn 15 g, peach kernel 10 g, pleione bulbocodioides 10 g, red sage root 20 g, and licorice root 6 g,) method combined with ultrasound-guided follicle aspiration (MFA) in treating refractory polycystic ovary syndrome (PCOS) found that BSHX method combined with MFA is a safe and effective treatment for refractory PCOS, with few trauma. The combined usage of Chinese herbal medicine could significantly reduce dosage of HMG used for promoting follicle and the production of multiple mature follicles, thus to avoid the risk of ovarian hyperstimulating syndrome (OHSS)(2).
3. Anticancer effects
In the study to compare the anticancer effects of flavonoids extracts of Scurrula parasitica from different host trees in vitro. 80% ethanol extracts of S. parasitica parasitizing on Nernium indicum, Morus alba, Opsmanthus fragrans, and Sapindus mulorossi were purified by polyamides column chromatography, and the eluates of 30%, 50%, 70% and 90% ethanol were mixed as flavonoids extracts. Extract of S. parasitica parasitizing on N. indicum (NISPEX) was the most sensitive to HL-60 cells of the 4 different host trees, the IC50 value being 0.60 mg x L(-1); and extract of S. parasitica parasitizing on M. alba took the second place, the IC50 value, being 2.49 mg x L(-1); extract of S. parasitica parasitizing on O. fragrans had no effectiveness as high as 50 mg x L(-1) concentration. NISPEX induced HL-60 cell apoptosis and inhibited the cell proliferation in dose and time-dependent manner. Cell cycles were arrested at G0-G1 phase after treated with NISPEX(3).
4. Diabetes
In the study of the Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats, showed that Tapinanthus nyasicus leaf, Ficus thoningii bark, Solanum incanum fruit, and Morus alba leaf extracts decreased weekly food consumption throughout the 5-week study period. Similar results were obtained for the groups treated with metformin or glibenclamide. However, food consumption was increased by S. incanum root, Aloe chabaudii leaf, or Allium sativum bulb extracts, and this was associated with high prevalence of diarrhea(4).
5. Etc.
Side Effects
1. Overdose can cause vomiting, diarrhea, etc.
2. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed?term=%09Taxillus%20chinensis%20%28DC.%29%20Danser.
(2) http://www.ncbi.nlm.nih.gov/pubmed/18543483
(3) http://www.ncbi.nlm.nih.gov/pubmed/18533504
(4) http://www.ncbi.nlm.nih.gov/pubmed/16801983
Chinese Herbs – Sang Ye (Folium Mori Albae)
Ingredients
1. Rutin
2. Quercetin
3. Isoquercitrin
4. Morocetin
5. Moracetin，
6. Quercetin-3-Triglucoside
7. Astraglin
8. Inokosterone
9. Ecdysterone
10. β-sitosterol
11. Uumbelliferone
12. Scopolin
13. α-，β-hexenal
14. Etc.
Health Benefits
1. Diabetes mellitus
In the study to a literature review aimed to analyse various studies related to the use of phytotherapy in diabetes mellitus in Turkey in order to provide additional information for healthcare professionals, indicated that among the herbs most-commonly used along with modern medical therapies and also in folkloric medicine, we searched for bitter melon, cinnamon, fenugreek, olive leaf, black seed and white mulberry. Studies conducted in this field have produced conflicting results and, the necessity to conduct randomized, placebo-controlled clinical human studies to develop new drugs from herbs, as in the case of metformin, still remains important. Besides, further studies are required to address the issues of standardization and quality control of existing preparations. More importantly, healthcare professionals caring for diabetic patients need to be aware of phytotherapy to incorporate phytomedicine into their practices and should undertake more responsibility in relation to these kind of therapies that are commonly-used throughout the world(1).
2. Oxidative stress
In the study to investigate the effects of ML in metabolic disorders and examined the mechanisms by which ML ameliorates metabolic disorders in db/db mice, found that ML ameliorates adipocytokine dysregulation at least in part through inhibiting oxidative stress in WAT of db/db mice, and that ML may be a basis for a pharmaceutical for the treatment of the metabolic syndrome as well as reducing adverse effects of pioglitazone(2).
3. Obesity or diabetes
In the study to investigate the ability of an extract of black, green, and mulberry tea leaves to induce malabsorption of carbohydrate and triacylglycerol in healthy volunteers, found that with the carbohydrate-containing meal, the tea extract resulted in a highly significant increase in breath-hydrogen concentrations, which indicated appreciable carbohydrate malabsorption. A comparison of hydrogen excretion after the carbohydrate-containing meal with that after the nonabsorbable disaccharide lactulose suggested that the tea extract induced malabsorption of 25% of the carbohydrate. The tea extract did not cause triacylglycerol malabsorption or any significant increase in symptoms and concluded that this study provides the basis for additional experiments to determine whether the tea extract has clinical utility for the treatment of obesity or diabetes(3).
4. Etc.
Side Effects
No side effects as known
Chinese Secrets To Fatty Liver And Obesity Reversal
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22125991
(2) http://www.ncbi.nlm.nih.gov/pubmed/19070857
(3) http://www.ncbi.nlm.nih.gov/pubmed/16960168
Chinese Herbs – Sang Shen (Fructus Mori)
Sang Shen is also known as Mulberry Fruit. The
sweet, sour and cold herb has been used in TCM to treat vertigo,
tinnitus, insomnia with palpitation, weak digestion, premature white
hair, thirst, diabetes with heat, diarrhea, etc., as it nourishes Yin,
tonifies Blood, promotes generation of Body Fluid, moistens the
Intestines, etc. by enhancing the functions of heart, liver and kidney
channels.
Ingredients
1. Resveratrol
2. Anthocyanosides
3. Carotene
4. Thiamine
5. Ribflavin
6. Vtamin C
7. Vannin
8. Linoleic acid
9. Stearic acid
10. Etc.
Health Benefits
1. Immunoregulation
In the study to investigate the immunomodulating activity of MF on the expression of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha), co-stimulatory molecules and also interferon-gamma (IFN-gamma) in macrophages and splenocytes, showed that MF could significantly induce the phosphorylation of signal molecules of MAPKs and the degradation of IkappaBalpha which finally led to the activation and nuclear translocation of nuclear factor-kappaB (NF-kappaB) for the target gene expression. All those notions disclosed that the aqueous extract MF is a new TLR4 activator, which induces a Th1 immune response as a consequence of induction of cytokines secretion, especially TNF-alpha and IFN-gamma(1).
2. Anti-diabetic effect
In the study to investigate the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, showed that PM021 also improved glucose tolerance in OLETO rats. However, PM021 had no effect on LETO rats, a control group of OLETF rats. Taken together, these findings indicate that PM021 has distinct anti-diabetic effects without any adverse effects or toxicities(2).
3. Antihyperglycemic effects
In the study of theAntihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice, fagomine (1), 4-O-beta-D-glucopyranosylfagomine (2), 3-O-beta-D-glucopyranosylfagomine (3), 3-epifagomine (4), 2,5-dideoxy-2,5-imino-D-mannitol (5), castanospermine (6), alpha-homonojirimycin (7), and 1-deoxynojirimycin (8) were evaluated for antihyperglycemic effects in streptozotocin (STZ)-diabetic mice. The insulin-releasing effects of 1 were also investigated. The blood glucose level fell after i.p. injection of the extract (50 mg/kg). Compounds 1, 2, 5, and 6 reduced the blood glucose level after i.p. injection of 150 mumol/kg. Compound 1 increased plasma insulin level in STZ-diabetic mice and potentiated the 8.3-mM glucose-induced insulin release from the rat isolated-perfused pancreas. The 1-induced potentiation of insulin release may partly contribute to antihyperglycemic action(3).
4. Etc.
Side Effects
1. Do not use in case of diarrhea
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19449343
(2) http://www.ncbi.nlm.nih.gov/pubmed/21524812
(3) http://www.ncbi.nlm.nih.gov/pubmed/9544568
Ingredients
1. Resveratrol
2. Anthocyanosides
3. Carotene
4. Thiamine
5. Ribflavin
6. Vtamin C
7. Vannin
8. Linoleic acid
9. Stearic acid
10. Etc.
Health Benefits
1. Immunoregulation
In the study to investigate the immunomodulating activity of MF on the expression of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha), co-stimulatory molecules and also interferon-gamma (IFN-gamma) in macrophages and splenocytes, showed that MF could significantly induce the phosphorylation of signal molecules of MAPKs and the degradation of IkappaBalpha which finally led to the activation and nuclear translocation of nuclear factor-kappaB (NF-kappaB) for the target gene expression. All those notions disclosed that the aqueous extract MF is a new TLR4 activator, which induces a Th1 immune response as a consequence of induction of cytokines secretion, especially TNF-alpha and IFN-gamma(1).
2. Anti-diabetic effect
In the study to investigate the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, showed that PM021 also improved glucose tolerance in OLETO rats. However, PM021 had no effect on LETO rats, a control group of OLETF rats. Taken together, these findings indicate that PM021 has distinct anti-diabetic effects without any adverse effects or toxicities(2).
3. Antihyperglycemic effects
In the study of theAntihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice, fagomine (1), 4-O-beta-D-glucopyranosylfagomine (2), 3-O-beta-D-glucopyranosylfagomine (3), 3-epifagomine (4), 2,5-dideoxy-2,5-imino-D-mannitol (5), castanospermine (6), alpha-homonojirimycin (7), and 1-deoxynojirimycin (8) were evaluated for antihyperglycemic effects in streptozotocin (STZ)-diabetic mice. The insulin-releasing effects of 1 were also investigated. The blood glucose level fell after i.p. injection of the extract (50 mg/kg). Compounds 1, 2, 5, and 6 reduced the blood glucose level after i.p. injection of 150 mumol/kg. Compound 1 increased plasma insulin level in STZ-diabetic mice and potentiated the 8.3-mM glucose-induced insulin release from the rat isolated-perfused pancreas. The 1-induced potentiation of insulin release may partly contribute to antihyperglycemic action(3).
4. Etc.
Side Effects
1. Do not use in case of diarrhea
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/19449343
(2) http://www.ncbi.nlm.nih.gov/pubmed/21524812
(3) http://www.ncbi.nlm.nih.gov/pubmed/9544568
Chinese Herbs – Sha Ren (Fructus Amomi)
Sha Ren is also known as Amomum Fruit. The
acrid, warm and nontoxic herb has been used in TCM as anti-ulcer,
inhibits secretion of stomach acid, anti-platelet coagulation agent and
to promote stomach and intestine movement and to bloating, stomach
ache, nausea, vomiting, lack of appetite, cold type of diarrhea, fetus
over active, etc. as its transforms Dampness, moves Qi, warms the
Middle, prevents miscarriage, etc. by enhancing the functions of spleen,
stomach and kidney channels.
Ingredients
1. Borneol
2. Camphor
3. Bornyl acetate
4. Linalool
5. Nerolidol
6. Saponin
7. Etc.
Health Benefits
1. Antioxidative activities
In the stduy of 16 commonly used soup making tonic Chinese medicinal herbs selected for antioxidative capacities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and ferric reducing antioxidant power (FRAP), and the total phenolic contents of these herbal extracts measured by the Folin-Ciocalteu method, confirmed that drinking tonic soups could supplement total antioxidants intake. Amongst the tested herbal extracts, extracts of Canarium album Raeusch., Flos caryophylli and Fructus amomi were found to have the highest antioxidative activities in both DPPH and FRAP assays. Their antioxidative activities were comparable to ascorbic acid and butylated hydroxytoluene(1).
2. Glucose uptake
In the study to to examine whether it had an enhancing effect on glucose uptake, an essential process of insulin action, found that aqueous ethanolic extract significantly stimulated glucose uptake in 3T3-L1 adipocytes at the concentration of 0.5 mg/ml. The extract significantly potentiated insulin-stimulated glucose uptake with a dose-dependent manner at a concentration range from 0.02 to 0.5 mg/ml. The results suggest that the antidiabetic action of Amomi may be mediated through the stimulation of glucose uptake and the potentiation of insulin action(2).
3. Anti cancers
In then study of Terpene glycosides and cytotoxic constituents from the seeds of Amomum xanthioides, showed that Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1 S,4 S,5 S)-5- EXO-hydroxycamphor 5-O-beta-D-glucopyranoside (2) and (1 R,4 R,5 S)-5-ENDO-hydroxycamphor 5-O-beta-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1 S,4 R,6 R)-(+)-6- ENDO-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines IN VITRO using a sulforhodamine B bioassay(3)
4. Estrogenic and antiestrogenic activities
in the study of Screening of estrogenic and antiestrogenic activities from medicinal plants, indicated that Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 7.75×10(-3); RP of 17β-estradiol=1), followed by Amomum xanthioides (1.25×10(-3)). Next potent were a group consisting of Glycyrrhiza uralensis, Zingiber officinale, Rheum undulatum, Curcuma aromatica, Eriobotrya japonica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum, and Pueraria lobata (root) (ranging from 9.5×10(-4) to 1.0×10(-4))(4).
5. Etc.
Side Effects
1. Do not use in case of Yin deficiency with heat
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18815744
(2) http://www.ncbi.nlm.nih.gov/pubmed/15099855
(3) http://www.ncbi.nlm.nih.gov/pubmed/19830656
(4) http://www.ncbi.nlm.nih.gov/pubmed/21783839
Ingredients
1. Borneol
2. Camphor
3. Bornyl acetate
4. Linalool
5. Nerolidol
6. Saponin
7. Etc.
Health Benefits
1. Antioxidative activities
In the stduy of 16 commonly used soup making tonic Chinese medicinal herbs selected for antioxidative capacities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and ferric reducing antioxidant power (FRAP), and the total phenolic contents of these herbal extracts measured by the Folin-Ciocalteu method, confirmed that drinking tonic soups could supplement total antioxidants intake. Amongst the tested herbal extracts, extracts of Canarium album Raeusch., Flos caryophylli and Fructus amomi were found to have the highest antioxidative activities in both DPPH and FRAP assays. Their antioxidative activities were comparable to ascorbic acid and butylated hydroxytoluene(1).
2. Glucose uptake
In the study to to examine whether it had an enhancing effect on glucose uptake, an essential process of insulin action, found that aqueous ethanolic extract significantly stimulated glucose uptake in 3T3-L1 adipocytes at the concentration of 0.5 mg/ml. The extract significantly potentiated insulin-stimulated glucose uptake with a dose-dependent manner at a concentration range from 0.02 to 0.5 mg/ml. The results suggest that the antidiabetic action of Amomi may be mediated through the stimulation of glucose uptake and the potentiation of insulin action(2).
3. Anti cancers
In then study of Terpene glycosides and cytotoxic constituents from the seeds of Amomum xanthioides, showed that Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1 S,4 S,5 S)-5- EXO-hydroxycamphor 5-O-beta-D-glucopyranoside (2) and (1 R,4 R,5 S)-5-ENDO-hydroxycamphor 5-O-beta-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1 S,4 R,6 R)-(+)-6- ENDO-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines IN VITRO using a sulforhodamine B bioassay(3)
4. Estrogenic and antiestrogenic activities
in the study of Screening of estrogenic and antiestrogenic activities from medicinal plants, indicated that Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 7.75×10(-3); RP of 17β-estradiol=1), followed by Amomum xanthioides (1.25×10(-3)). Next potent were a group consisting of Glycyrrhiza uralensis, Zingiber officinale, Rheum undulatum, Curcuma aromatica, Eriobotrya japonica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum, and Pueraria lobata (root) (ranging from 9.5×10(-4) to 1.0×10(-4))(4).
5. Etc.
Side Effects
1. Do not use in case of Yin deficiency with heat
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/18815744
(2) http://www.ncbi.nlm.nih.gov/pubmed/15099855
(3) http://www.ncbi.nlm.nih.gov/pubmed/19830656
(4) http://www.ncbi.nlm.nih.gov/pubmed/21783839
Chinese Herbs – Sha Shen (Radix Adenophorae seu Glehniae)
Sha Shen is also known as adenophora. The
sweet, cold and bitter herb has been used in TCM to stop coughs,
nourishes stomach and generates fluids, etc., as it clears the Lungs,
nourishes Lung-Yin, benefits the Stomac, promotes generation of Body
Fluids, etc. by enhancing the functions of ling and stomach channels.
Ingredients
1. Alkaloids
2. Phytosterol
3. Beta-sitosterol
4. Beta-sitosterol-O-beta-D-glucopyranoside
5. Taraxerone
6. Octacasanoic acid
7. Etc.
Health Benefits
1. Gastric hypermotility
In the study to investihgte the effect of Shashen Maidong Decoction (SSMDD) on the gastric motility of mice and rats in vivo, showed that 7 g/kg could inhibit significantly the gastric hypermotility induced by subcutaneous injection of indomethacin (40 mg/kg), but had no obvious effect on the gastric hypermotility induced by intramuscular injection of reserpine (0.4 mg.kg-1.d-1 x 4 d)(1).
2. Chronic atrophic gastritis
In the assess to investigate Xiang-sha Warming (XSW) and Shashen Nourishing Decoction (SSN) used in treating Yang Deficiency Syndrome (YaDS) and Yin Deficiency Syndrome (YiDS) of chronic atrophic gastritis (CAG) respectively, showed that in Spleen YiDS showed marked effect after 3-month treatment. It showed that the effect in Spleen YaDS was better than YiDS. The XSW was superior than that of SSN. The effects were related to the syndromes and the degrees of pathologic change. This showed that the recipe could somewhat reverse and restore the abnormal glands of gastric mucosa(2).
3. Etc.
Side Effects
1. Do not use the herb in case of Wind-cold or in case of spleen deficiency
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/9208540
(2) http://www.ncbi.nlm.nih.gov/pubmed/8339030
Ingredients
1. Alkaloids
2. Phytosterol
3. Beta-sitosterol
4. Beta-sitosterol-O-beta-D-glucopyranoside
5. Taraxerone
6. Octacasanoic acid
7. Etc.
Health Benefits
1. Gastric hypermotility
In the study to investihgte the effect of Shashen Maidong Decoction (SSMDD) on the gastric motility of mice and rats in vivo, showed that 7 g/kg could inhibit significantly the gastric hypermotility induced by subcutaneous injection of indomethacin (40 mg/kg), but had no obvious effect on the gastric hypermotility induced by intramuscular injection of reserpine (0.4 mg.kg-1.d-1 x 4 d)(1).
2. Chronic atrophic gastritis
In the assess to investigate Xiang-sha Warming (XSW) and Shashen Nourishing Decoction (SSN) used in treating Yang Deficiency Syndrome (YaDS) and Yin Deficiency Syndrome (YiDS) of chronic atrophic gastritis (CAG) respectively, showed that in Spleen YiDS showed marked effect after 3-month treatment. It showed that the effect in Spleen YaDS was better than YiDS. The XSW was superior than that of SSN. The effects were related to the syndromes and the degrees of pathologic change. This showed that the recipe could somewhat reverse and restore the abnormal glands of gastric mucosa(2).
3. Etc.
Side Effects
1. Do not use the herb in case of Wind-cold or in case of spleen deficiency
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/9208540
(2) http://www.ncbi.nlm.nih.gov/pubmed/8339030
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