Menopause is a condition in which a woman is in the transition stage of permanent cessation of the ovary's functions in egg production because of less production of estrogen and progesterone, signaling the end of the reproductive phase of a woman's life.
In menopause, menstruation has become irregular and slowly stops over time, but in some women, menstrual flow comes to a sudden halt.
Some researchers suggested that you officially enter the stage of menopause if you have gone 12 months without a menstrual period.
Compared to menopause, peri-menopause is a condition in which women experience an irregular menstrual cycle due to the hormonal decline gradually, including shorter, longer, heavy, light periods and some menopause symptoms.
Perimenopause, in fact, is a transition stage to menopause, and the length of this transition can be 3-10 years or longer. Once you have no menstrual period in 12 consecutive months, you have officially entered 12 months of menopause already.
Women enter the menopause stage differently, but the average age is 51 in the United States.
Women with ovarian failure or removed may experience symptoms of menopause at the early age of 38.
Symptoms of menopause are the result of the gradually reduced production of estrogen and progesterone, the 2 most abundant hormones in childbearing-age women.
Most women in the Western world experience symptoms of hot flashes and emotional symptoms of menopause may disrupt your sleep, lower your energy or affect emotional health.
Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.
In finding a potential phytochemical for the treatment of menopausal symptoms, researchers elucidated the biological activities of Pueraria lobata (PL) on menopause-related metabolic diseases.
According to the results of ovariectomized (OVX) rats as a postmenopausal model that was administered PL at different doses (50, 100, and 200 mg/kg),* The decreased uterine weights and PPAR-γ (peroxisome proliferator-activated receptor-gamma) mRNA expression in the thigh muscle found in menopausal females in the ovariectomized (OVX) rats were significantly recovered after PL administration.
* Furthermore, PL also significantly alleviated OVX-induced increases in total cholesterol, triglyceride, alanine aminotransferase (ALT/GPT), and aspartate aminotransferase (AST/GOT) levels.
More precisely, the efficacy of Pueraria lobata (PL) on menopause-related metabolic diseases was attributed to four potential active compounds, including beta-sitosterol.
In other words, the chemical compounds exerted a strong activity against multiple targets among female sex hormone-related pathways, including the estrogen signaling pathways, progesterone-mediated oocyte maturation, oxytocin signaling pathways, and prolactin signaling pathways.
Based on the findings, researchers said, "PL improved various indicators associated with lipid metabolism in the postmenopausal animal model".
Beta-Sitosterol may be considered a remedy for the prevention and treatment of menopausal symptoms, pending the confirmation of the larger sample size and multicenter human study.
Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Investigating the Systems-Level Effect of Pueraria lobata for Menopause-Related Metabolic Diseases Using an Ovariectomized Rat Model and Network Pharmacological Analysis by Oh JH1, Baek SE2, Lee WY1, Baek JY3,4, Trinh TA3, Park DH3, Lee HL5, Kang KS3, Kim CE1, Yoo JE. (PubMed)
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