Immunomodulators are agents that modify the immune response or the functioning of the immune system such as the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.
In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending on the body's needs.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.
The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.
Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.
In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.
These activities played an important in inducing apoptosis and reducing the proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.
Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
On findings a natural wholefood for the prevention of infectious disease, researchers examined the effects of Quercetin, a great representative of polyphenols, flavonoids subgroup, flavonols found in broccoli on the immune response.
Quercetin exhibited antioxidant activity in radical scavenging and anti-allergic properties by stimulation of the immune system against the antiviral activity, histamine release,
Furthermore, quercetin also modulated the immune response by decreasing the pro-inflammatory cytokines, leukotrienes creation, and suppressing interleukin IL-4 production.
The antioxidant improved the Th1/Th2 balance, and restrain antigen-specific IgE antibody formation.
Moreover, quercetin was also effective in the inhibition of enzymes such as lipoxygenase, eosinophil, and peroxidase by suppressing inflammatory mediators.
Based on the results, researchers wrote, " All mentioned mechanisms of action contribute to the anti-inflammatory and immunomodulating properties of quercetin that can be effectively utilized in the treatment of late-phase, and late-late-phase bronchial asthma responses, allergic rhinitis, and restricted peanut-induced anaphylactic reactions".
And "Plant extract of quercetin is the main ingredient of many potential anti-allergic drugs, supplements and enriched products".
Taken altogether, broccoli containing high amounts of quercetin may be considered a functional food for the improvement of the immune response, pending confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin and Its Anti-Allergic Immune Response by Mlcek J1, Jurikova T2, Skrovankova S3, Sochor J. (PubMed)
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