Thursday 29 April 2021

Tocopherols Lower the Risk of Gallstone Diseases

By Kyle J. Norton

The gallbladder is a small organ under the liver with a function of aiding the digestive system in fat metabolism and storing of the bile produced by the liver.

The gallbladder also plays a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.

Gallbladder disease is a condition of inflammation or gallstones of the gallbladder.
A gallstone is a stone formed within the gallbladder out of bile components as a result of building up undissolved cholesterol over a prolonged period of time.

Gallstones can cause blockage of the flow of bile through the bile ducts,  leading to inflammatory causes of acute cholecystitis. Gallstones are most common among older adults, women, overweight people, etc.

According to the statistic, approximate 20 millions of the US population have some kinds of Gallbladder Disease.

The most common symptoms are
* Upper gastrointestinal bleeding if ruptured

* Right upper quadrant or midline epigastric pain

*  Abdominal pain
Gallstones are relatively rare in children. Some gallstones are radiopaque and can be visualized on plain abdominal radiography.

* Other symptoms may include mid-upper abdominal pain,  biliary pain, and colic.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of digestive diseases, researchers examined the effect of tocopherols on gallstone diseases.

According to the analysis of plasma levels of α- and γ-tocopherol using high-performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women),
* Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13-0.76).

* γ-tocopherol/cholesterol ratio showed a lower probability of having gallstone disease. However, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35-1.69 for 3rd vs 1st tertile).


In other words, levels of α-tocopherol associated with levels of cholesterol showed a significant lowering the risk of gallstone diseases, compared to the ratio of γ-tocopherol/cholesterol

After talking about other factors into account, researchers said, "our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies.".

Taken altogether, tocopherols may be considered adjunct therapies in the treatment of gallstone diseases, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease by Waniek S1, di Giuseppe R2, Esatbeyoglu T3, Ratjen I4, Enderle J5, Jacobs G6,7, Nöthlings U8, Koch M9,10, Schlesinger S11, Rimbach G12, Lieb W. (PubMed)

No comments:

Post a Comment