Beta-Sitosterol Processes Anti Endometriosis in Vivo

By Kyle J. Norton

The endometrium is the inner lining of the mammalian uterus that is very susceptible to hormone change, particularly in the menstrual cycle.

The endometrium is also a reproductive organ where the implantation takes place. In the absence of periodic hormonal influence, before puberty or following menopause, this tissue has a constant morphology and thickness.

Endometriosis is a painful disorder characterized by endometrial cells that grow in another area in the reproductive organs, such as ovaries, fallopian tubes,..... and the tissue lining your pelvis, outside of the uterus.

The causes of endometriosis are debatable. Some researchers suggested that normally a layer of the endometrial lining in the inside of the uterus is expelled through menstruation, during the last stage of the menstrual cycle, instead, some of the endometrial tissues grow somewhere else in the body, causing endometriosis.

According to the stage of severity, endometriosis can be classified into, 

* Minimal stage:
The top surface, few in number. Commonly they are found in the inside wall of uterus, ligaments, and ovary.

*  Mild stage:
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.

* Moderate stage:
Many implants, endometrial cysts present, affecting ovary function, causing scar tissues and adhesion is also present.

* Severe stage:
Intensive peritoneal implants, large endometromas present and dense adhesion.

Each woman experiences differently from endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain at all, while other women may only be in the early stage of endometriosis but have excessive pain.

Beta-Sitosterol is a phytochemical in the class of phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of reproductive diseases in women, researchers examined the effects of Anthemis austriaca Jacq. flowers in gynecological disorders, on the rat endometriosis model.

According to the results of the administration of the extracts from n-hexane, ethyl acetate (EtOAc), and methanol (MeOH) isolated from the Anthemis austriaca Jacq. flowers,
* The MeOH extract reduced the adhesion scores and endometrial foci areas from 3.1 to 1.1 (p < 0.01) and from 86.4 to 40.5 (p < 0.01), respectively

* Furthermore, the MeOH extract reduced tumor necrosis factor (TNF)-α, vascular endothelial growth factor (VEGF), and interleukin (IL)-6 levels of the peritoneal fluids from 13.7 to 3.8 (p < 0.01), from 28.4 to 16.3 (p < 0.05) and from 50.2 to 24.3 (p < 0.01), respectively.

* Interestingly, After the MeOH extract was fractionated, the obtained subfractions A and C of the MeOH extract displayed statistically significant activity on the endometriosis rat model, particularly the compound β-sitosterol-3-O-β-D-glucopyranoside.

Based on the findings, researchers said, "flavonoids and sterols of the plant were detected as the possible compounds responsible for the activity".

Beta-Sitosterol, a major compound of sterols may be considered a remedy for the prevention and treatment of endometriosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Promising activity of Anthemis austriaca Jacq. on the endometriosis rat model and isolation of its active constituents by Ilhan M1,2,3, Ali Z3, Khan IA3, Taştan H4, Küpeli Akkol E. (PubMed)