Sunday, 21 March 2021

Herbal Angelica Processes Anti- Cancer Activity in Vitro

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reactions that can not be stopped until all electrons are paired or inhibited by antioxidants.

Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.

Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cells and lipid damage, leading to alteration of cell DNA, a leading cause of cancer.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of diseases associated with DNA alternation, the researchers examined the effects of Angelica n-Butylidenephthalide (BP) anti-cancer activity.

According to the assays that the results from the application of riboflavin-5'-phosphate (RFMP) immobilized iron oxide magnetic nanoparticles (Fe3O4 MNPs) as carriers for BP to treat cancer cell lines overexpressed riboflavin receptors on their cell membrane-derived from liver, prostate, breast, cancer cells
* BP treatment. showed a strong sensitivity to the tested cell lines.

* BP-binding free riboflavin-5'-phosphate (RFMP) on MNPs to target these model cells during the period of treatment by readily released on target cancer cells.

* Fe3O4@RFMP MNPs immobilized with BP released free-form BP at a similar amount for the inhibition of cancer cells, with no apparent harmful effects on non-target cells.

* BP-Fe3O4@RFMP MNPs upregulated the level of cysteine-aspartic acid protease 3 (caspase 3) associated with cancer cell apoptosis.

Taken altogether, Herbal Angelica may be sued for the treatment of cancer, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Riboflavin immobilized Fe3O4 magnetic nanoparticles carried with n-butylidenephthalide as targeting-based anticancer agents by Wu CY1, Chen YC. (PubMed)

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