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Tuesday, 29 September 2015

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: TCM Herbal medicine for Spleen Yang deficiency - Du Zhong(Eucommia Bark)


By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Polycystic Ovarian Syndrome


Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).

In Traditional Chinese Medicine Perspective


While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).

PCOs Treatment according traditional Chinese medicine


Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into



Spleen yang deficiency


Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....

5.  Du Zhong(cortex Eucommiae Ulmoidis)
Du zhong, the sweet, slightly acrid, and warm herb, also known as eucommia bark used in traditional Chinese medicine as immune enhancer(2308)(2310),  diuretic(2311), sedative(2312), anti inflammatory(2313)(2314) advocate,....... and for treatment of chronic pain in lower back and knees, lack of strength, dizziness, impotence, irregular menses and frequent urination, unstable pregnancy, chronic pain in lower back and excessive movements of fetus,... as its tonifes the kidney and liver and enhances the functions of kidney and liver functions(2307).

Chemicals constituents(2309)
1. Betulin
2. Byringin
3. Pervoside A
4. Glucosyringic acid
5. Vanillic acid-beta-glucoside
6. Geniposide acid
7. Aucubin
8. Geniposide
9. Pinoresinol-4,4'-di-O-beta-D-glucopyranoside
10. Syringaresinol di-O-beta-D-glucopyranoside
11. Medioresinol di-O-beta-D-glucopyranoside
12. Sucrose
13. Ethyl beta-glucopyranoside
14. Etc.

In metabolic syndrome, du zhong showed to attenuate hypertension(2316)(2319)(2321) through exhibiting  beta-adrenergic blocking activity(2319) and regulating NO and renin-angiotensin system (RAS) and directly relaxing artery(2321); obesity(2316)(2317)(2318) and improve insulin resistance(2318) or hyperlipaemia(2318)(2316), through suppressed increases body weight(2317), white adipose tissue weight(2317), plasma triglyceride levels(2317) and free fatty acids level(2317) and through secretion and regulation of adipocytokines(2318); hyperglycemia(2323),
sexual dysfunction(2316), and complications of diabetes(2316)(2324) through antioxidant(2324) activity and altered the plasma and hepatic lipid levels by lowering the cholesterol and triglyceride concentrations, while elevating the plasma HDL-cholesterol level(2125).
Dr. Park and research team at the Yeungnam University said "Du-zhong extract is potentially beneficial for the prevention and management of complications of type 2 diabetes"(2324); and cardiovascular disease(2320) through reversed hypertensive vascular remodelling(2320)(2322)(2323) and inhibited angiotensin II (Ang II) expression in stimulated extracellular matrix biosynthesis in mesangial cell(2322)(2323)
According to study, compound FF16, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, was found effectively  in enhanced glucose-stimulated insulin secretion through increased islet amount, the enlarged islet area by protecting the pancreatic beta-cells(2315).

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(2307)Du zhong((Complementary and Alternative Healing University)
(2308) The effects of certain immunity systemic advuvants, PHA, and human gamma globulin on the thymic cortex of mice: a light and electron microscope study by Khalil A, Rappaport H, Dantchev D, Florentin I, Bourut C.(PubMed)
(2309)[Chemical constituents of Eucommia ulmoides]. [Article in Chinese] by Wang SY, Ding LF, Wu XD, Wang HY, Zhao QS, Song LD.(PubMed)
(2310) [Comparison of immunity improving effects of different processed cortex Eucommiae] [Article in Chinese] by Zhu Y1, Hao W, Li X.(PubMed)
(2311) Chinese Acupuncture and Herbal Medicine Clinical Reference By Paul Robin, Paul Brecher
(2312) [Adjunctive treatment of axial undifferentiated spondyloarthritis by Qiangji Recipe: a clinical study]. [Article in Chinese] by He MY, Fan FY.(PubMed)
(2313) [Effect of bushen qiangdu recipe on osteoporosis and bone loss of patients with ankylosing spondylitis]. [Article in Chinese] by Wang H1, Yan XP, Kong WP.(PubMed)
(2314) Elucidation of anti-inflammatory potencies of Eucommia ulmoides bark and Plantago asiatica seeds by Kim BH1, Park KS, Chang IM.(PubMed)
(2315) [Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum on metabolic syndrome treatment III--controlling blood glucose]. [Article in Chinese]  by Tian JY1, Chen L, Zhang XL, Li J, Han J, Yang XM, Zhang PC, Du PG, An LP, Ye F.(PubMed)
(2316) Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. He X1, Wang J2, Li M3, Hao D1, Yang Y4, Zhang C1, He R1, Tao R5.(PubMed)
(2317) Anti-obesity compounds in green leaves of Eucommia ulmoides by Hirata T1, Kobayashi T, Wada A, Ueda T, Fujikawa T, Miyashita H, Ikeda T, Tsukamoto S, Nohara T.(PubMed)
(2318) Chronic administration of Eucommia leaf stimulates metabolic function of rats across several organs by Fujikawa T1, Hirata T, Wada A, Kawamura N, Yamaguchi Y, Fujimura K, Ueda T, Yurugi Y, Soya H, Nishibe S.(PubMed)
(2319) A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension by Greenway F1, Liu Z, Yu Y, Gupta A.(PubMed)
(2320) Effects of lignans extracted from Eucommia ulmoides and aldose reductase inhibitor epalrestat on hypertensive vascular remodeling by Gu J1, Wang JJ, Yan J, Cui CF, Wu WH, Li L, Wang ZS, Yu M, Gao N, Liu L, Ouyang DS.(PubMed)
(2321) Antihypertensive effect of Eucommia ulmoides Oliv. extracts in spontaneously hypertensive rats by Luo LF1, Wu WH, Zhou YJ, Yan J, Yang GP, Ouyang DS.(PubMed)
(2322) Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders by Fyhrquist F1, Metsärinne K, Tikkanen I.(PubMed)
(2323) Lignans from the bark of Eucommia ulmoides inhibited Ang II-stimulated extracellular matrix biosynthesis in mesangial cells by Li ZY, Deng XL, Huang WH, Li L, Li H, Jing X, Tian YY, Lv PY, Yang TL, Zhou HH, Ouyang DS1.(PubMed)
(2324) Eucommia ulmoides Oliver leaf extract increases endogenous antioxidant activity in type 2 diabetic mice by Park SA1, Choi MS, Jung UJ, Kim MJ, Kim DJ, Park HM, Park YB, Lee MK.(PubMed)
(2325) Hypoglycemic and hypolipidemic action of Du-zhong (Eucommia ulmoides Oliver) leaves water extract in C57BL/KsJ-db/db mice by Park SA1, Choi MS, Kim MJ, Jung UJ, Kim HJ, Park KK, Noh HJ, Park HM, Park YB, Lee JS, Lee MK.(PubMed)