Healthy Food Cabbage, in Reducing the Risk of Cervical Cancer Developing

By Kyle J. Norton

Cervix formed part of the reproductive organ, is the lower part of the uterus that opens at the top of the vagina.

The cervix acts as a transition area (squamous columnar epithelium) for vaginal lining (squamous epithelium) to the uterus (columnar epithelium) to host the development of the fetus.

Cancer is the class of diseases associated with cell growth disorderly and uncontrollably due to the alternation of DNA.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

Researchers do not know what causes cervical cancer. Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. At this stage, most women with cervical cancer do not experience any symptoms.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients.

Epidemiological also suggested that HPV infection, sexual activity, smoking, giving birth many times. Infection with the human immunodeficiency virus (HIV, history of sexually transmitted infections (STIs) and long-term use of oral contraceptives are some prevalent risk factors of cervical cancer.

The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of green leaves, but in some varieties, it may be red or purplish.

With an aim to find a natural food that reduces the risk of malignant tumors, researchers investigated the activity of Indole-3-Carbinol (I3C), a phytochemical (derived from cabbage, and other cruciferous vegetables) on the reduction of cervical intraepithelial neoplasia (CIN) and its progression to cervical cancer.

According to the tested assays,
* In vitro, I3C inhibited the diminished PTEN expression during the progression from low-grade to high-grade cervical dysplasia in humans, 

In other words, the gene associated with tumor-suppressing activity not only was significantly inhibited before the onset of cervical cancer in patients with high-grade cervical dysplasia but also play a critical role in the initiation and progression of cervical intraepithelial neoplasia (CIN).

* In vivo, K14HPV16 transgenic mice model induced cervical cancer exerted overexpression of hormone estrogen.

* Dietary I3C in the tested models increased PTEN expression in the cervical epithelium of the transgenic mouse, to reduce the risk of development of cervical cancer.

Taken altogether, cabbage processed abundantly antioxidant I3C, may be considered a functional remedy for the prevention of cervical cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo by Qi M1, Anderson AE, Chen DZ, Sun S, Auborn KJ. (PubMed)

Broccoli, the Natural Detoxified Remedy

By Kyle J. Norton


Detoxification is a natural process in the removal of toxic substances of the human body, mainly carried out by the liver and kidney.

According to statistics, thousands of new chemicals are registered for use in foods, medications, household products, and lawn-care products, these types of environmental toxins also add to the risk of chronic illness in long term exposure.

Particularly, these chemical substances induced developmental toxins and neurotoxins exposed to pre- or post-natal babies have never been studied.

Some researchers suggested that detoxification also includes balancing the levels of antioxidants and free radicals.

Overexpression of ROS species caused by toxins accumulation may precipitate the elevation of oxidative stress and cytotoxicity that can lead to healthy cell DNA alternation.

In other words, increased antioxidant enzymes in the production of host antioxidants such as superoxide dismutase, superoxide dismutases (SODs),..... that break down the superoxide anion into oxygen and hydrogen peroxide may decrease oxidative stress by restoring the ratio of free radicals and antioxidants in the body.

Other common symptoms of toxin accumulation in the body include chronic fatigue, body odor, insomnia, food or chemical sensitivities and headaches.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of broccoli sprout extract (BSEx) on liver gene expression and acute liver injury in the rat.

The study included male rats that were divided into the control group fed the AIN-76 diet, and the BSEx group fed the AIN-76 diet containing BSEx for 10-days.

According to the results of rats, after a 10-d feeding period sacrificed, BSEx promoted the expression of genes related to detoxification and glutathione synthesis in normal rat liver.

APAP + BSEx fed groups significantly suppressed the levels of AST (70.91 ± 15.74 IU/mL vs 5614.41 ± 1997.83 IU/mL, P < 0.05) and ALT (11.78 ± 2.08 IU/mL vs 1297.71 ± 447.33 IU/mL, P < 0.05), compared to the APAP group.

Furthermore, he level of antioxidant ezymes, GSH (2.61 ± 0.75 nmol/g tissue vs 1.66 ± 0.59 nmol/g tissue, P < 0.05) and liver GST activity (93.19 ± 16.55 U/g tissue vs 51.90 ± 16.85 U/g tissue, P < 0.05) were significantly increased in the APAP + BSEx group compared with the APAP group.

Although AST (4820.05 ± 3094.93 IU/mL vs 12465.63 ± 3223.97 IU/mL, P < 0.05) and ALT (1808.95 ± 1014.04 IU/mL vs 3936.46 ± 777.52 IU/mL, P < 0.05) levels were significantly suppressed in the D-GalN + BSEx group. However, compared with the D-GalN group, the levels of AST and ALT in the D-GalN + BSEx group were higher than those in the APAP + BSEx group.

And, the level of GST activity was significantly higher in the D-GalN + BSEx group compared with the D-GalN group (98.04 ± 15.75 U/g tissue vs 53.15 ± 8.14 U/g tissue, P < 0.05).

Based on the evidence, researchers said, "BSEx protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis".

Taken altogether,  broccoli may be considered liver detoxed functional food, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury by Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y. (PubMed)

Herbal Angelica in the Prevention and Treatment of Osteoporosis

By Kyle J. Norton

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

The condition is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries and considered as a major health problem in both elderly men and women.

Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.

Osteoporosis is the common disease among the elderly, probably due to the aging effect that induces nutrition deficiency such as
* Vitamin D insufficiency and reduced calcium absorption,

* Reduced hormone production, the drop of estrogen levels after menopause, can speeds up bone loss.

* Reduced production of bone mass and increased bone reabsorption due to the balance shifts in favor of osteoclasts compared to those of osteoblasts.

Osteoclastogenesis is a procedure that included many stages, that interfere with the specific stage of the process, diseases associated with imbalanced osteoclasts and osteoblast that may be preventable in the future.

The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone that leads to bone resorption.

In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.

Furthermore, the imbalance of osteoclasts and osteoblast also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the improvement of bone mineral density, researchers examined the phytochemical Ligustilide (LIG), the main component of A. sinensis anti-osteoporotic effects.

According to the tested analysis, LIG significantly ameliorated inhibition of bone formation in zebrafish caused by prednisolone.

Furthermore, the application also showed a strongly promoted osteoblast differentiation, including that of the pre-osteoblastic cell line MC3T3-E1 and bone marrow mesenchymal stem cells by reducing the oxidative stress to induce cell apoptosis by free radical H2O2 and enhancing the protein (Bcl-2) associated with anti-apoptotic functioning

The promotion of bone density of LIG was also found to induce the metabolic reaction of EGFR and ERK1/2 associated with instructions for making a receptor protein involved in bone formation by blocking the GPR30 signaling to induce bone mass increasing.

Collectively, researchers said, "the results reveal that GPR30 is a positive switch for LIG to increase bone formation via regulation of EGFR, and these results provide evidence for the potential of LIG to treat osteoporosis".

Taken altogether, Herbal Angelica consists of LIG. maybe considered a functional herbal medicine for reducing the risk of osteoporosis, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway by Yang F1,2, Lin ZW1,2, Huang TY1,2, Chen TT1,2, Cui J1,2, Li MY1,2, Hua YQ. (PubMed)

Herbal Angelica, Processes Apoptotic and Anti Proliferative Function in Vitro

By Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.

In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.

In the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.

A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.

In the programmed cell death gene, such as BCL-2 induce cell death by either inducing apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.

In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of cancer, researchers examined the effects of Angelica phytochemical (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone from A. purpuraefolia on cell proliferation and apoptotic cell death.

In 4 breast (MDA-MB-231, MCF-7, HS578T, and T47D), three cervical (HeLa, SiHa, and C33A) cancer cell lines, and NIH 3T3 normal cells used for the experiment, researchers found that
* (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone treatment suppresses the growth and proliferation of cancer cells at a relatively low concentration (<10 μg/ml).

* The phytochemical also induces cancer cell apoptosis at a high concentration (>50 μg/ml).

* At the concentration of 10 μg/ml, the chemical compounds also exerted a strong cell cycle arrest in the S/G2 phase.

Furthermore, according to the Western blot analysis, the concentration higher than 50 μg/ml of (+)-4'-decanoyl-cis-khellactone increased the large percentage of apoptotic cells in a time-dependent manner.

Interestingly, while the (+)-4'-decanoyl-cis-khellactone using both extrinsic and intrinsic pathways to induce apoptosis, the but (+)-3'-decanoyl-cis-khellactone uses only an intrinsic pathway for the same results.

In other words, the (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone also inhibited the in vitro proliferation of six other human breast and cervical cancer cell lines with different pathways.

Based on the evidence, researchers said, "Our data strongly suggest that (+)-4'-decanoyl-cis-khellactone and (+)-3'-decanoyl-cis-khellactone act as an anti-cancer supplement particularly against breast and cervical cancers by inducing cell cycle arrest in the S/G2 phase and caspase-dependent apoptosis at relatively low and high concentrations, respectively".

Taken altogether, Herbal Angelica processes anti-proliferative activity against cancer, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effect and mechanism on antiproliferation of khellactone derivatives from herbal suitable for medical or food uses by Jung S1, Li C, Lee S, Ohk J, Kim SK, Lee MS, Moon HI. (PubMed)

Herbal Coltsfoot(Tussilago farfara) Processes Anti Cancer and Bacterial Infections Activity

By Kyle J. Norton

Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.

At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of cancer.

Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.

According to the statistic provided by the American Cancer Society, in the US 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are results of cancer.

Furthermore, in the age perspective, older adults although are accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

Bacterial infections are a class of diseases caused by harmful bacteria.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistic provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.

On finding a potential compound for the treatment of malignant tumors and diseases associated with bacterial infections, scientists examined the Sesquiterpenoids from the flower bud extract of Tussilago farfara as a reducing agent for eco-friendly synthesis of silver and gold nanoparticles for the treatment of cancer and infectious diseases.

Where the silver and gold nanoparticles had a characteristic surface plasmon resonance at 416 nm and 538 nm, respectively.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

According to the tested analysis, the silver nanoparticles showed a significantly better activity (two- to four-fold enhancement) on both Gram-positive and Gram-negative bacteria, compared to the extract.

The gold nanoparticles exerted a strong anti-cancer cytotoxic activity compared to those of silver nanoparticles.

Furthermore, both gold and silver nanoparticles. demonstrated the highest cytotoxicity on human pancreas ductal adenocarcinoma cells.

Based on the results, researchers said, "Therefore, both nanoparticles synthesized with the sesquiterpenoids from T. farfara flower bud extract can be applied as drug delivery vehicles of anticancer or antibacterial agents for future nanomedicine applications".

Taken altogether, coltsfoot may be considered a remedy for the treatment of bacterial infections and cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities by Lee YJ1, Song K2, Cha SH3, Cho S4, Kim YS5, Park Y. (PubMed)

Broccoli Enhances Xenobiotic Metabolism Against the Risk of Cancer

By Kyle J. Norton

Xenobiotic metabolism is an action that protects the host against chemicals that affect normal metabolism.

Other common metabolisms may include

* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, also has been found to protect the gut mucosal barrier in preserving the ability to absorb nutrients.

* Drug metabolism is the process to alter chemical of a drug that may cause harm to the body

The gut microbiota plays a critical role in regulating the systemic metabolism of the host including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile by interacting with other organs such as intestine, liver, brain, and other organs through the host-microbiota and co-metabolism structure to form an ametabolic axis.

More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of the dietary nutrients of the digestive system

* Gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.

* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

Imbalanced of the ratio of gut microbiota may have a negative impact on human health and diseases.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects sulforaphane (SF), the isothiocyanate derived from 4-methyl-sulphinyl butyl glucosinolate in broccoli induce-xenobiotic metabolizing.

The study included 16 subjects randomized, into 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.

According to the results of the trial, consumption of high glucosinolate broccoli showed a strong effect in the improvement of several xenobiotics metabolizing genes, including thioredoxin reductase, Aldo-keto reductases, and glutamate-cysteine ligase modifier subunit.

Furthermore, the affected genes also have been found to be improved after exposure to SF, in cell and animal models.

Compared to phytochemical sulforaphane (SF) and sulforaphane (SF), only 1 such gene was affected in the consumption of standard broccoli.

Taken altogether, the consequences of these results suggest that the broccoli process the potential anticarcinogenic activity by upregulating the gene associated with xenobiotic metabolism, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Consuming broccoli does not induce genes associated with xenobioticmetabolism and cell cycle control in human gastric mucosa by Gasper AV1, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barrett DA, Mithen RF. (PubMed)

Dandelion (Taraxacum officinale), the Best Antioxidant Functional Herbal Medicine

By Kyle J. Norton

Antioxidants are stable atoms that inhibit oxidation caused by free radicals.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.

Believe it or not, free radicals also play a critical role in maintaining a certain body function. The Journal of Physiology showed that free radicals act as signal substances that cause the heart to beat with the correct force.

In healthy individuals, antioxidant enzymes produced by the liver are good enough to balance the free radical produced by the cell metabolism and external sources such as the air we breathe and the food we eat.

However, in people with a weakened immune system such as infants, children and the elderly, dietary sources from supplements, fruits and vegetables may be needed.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world.

The herbal medicine has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined in vitro and in vivo the antioxidant effects of 70% ethanol-water (v/v) leaf and root extracts of T. officinale (TOL and TOR, respectively).

The study included organ homogenate samples from Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats, treated by leaf extracts of TOL (500 mg/kg/day) and TOR (500 mg/kg/day) for 21 days.

Based on the results from the experiment, the antioxidant contents of ) polyphenol (4.35 ± 0.15 compared to 1.14 ± 0.01) and flavonoid (23.17 ± 0.14 compared to 3 ± 0.05) of TOL are significantly higher compared to TOR.

TOL exerted a significantly higher free radical scavenging activity (EC50 0.37 compared to 1.34 mg/mL) and total antioxidant capacities (82.56% compared to 61.54% ABTS, and 156 ± 5.28 compared to 40 ± 0.31 FRAP) compared to TOR.

Furthermore, both extracts inhibited the oxidative stress marker MDA levels and increased the total antioxidant capacity (TAC) without inducing toxicity with LD50 > 5000 mg/kg).

Collectively, T. officinale leaf extract possesses significant anti-oxidant effects that conferred significant in vivo antioxidant protection against free radical-mediated oxidative stress in L-NAME-induced hypertensive rats.

Taken altogether, dandelion may be considered a remedy for enhancing the antioxidant capacity against oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats by Aremu OO1, Oyedeji AO2, Oyedeji OO3, Nkeh-Chungag BN4, Rusike CRS, (PubMed)