Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Saturday 24 August 2019

Healthy Legume Navy Bean Prevents the Onset OF Oxidative Stress Naturally

By Kyle J. Norton

Oxidative stress is a condition associated with overexpression of free radical as a result of a chain reaction that can not be stopped.

More precisely, oxidative stress is caused by the imbalance of the ratio of free radicals and antioxidant produced by the host.

Antioxidants are stable atoms that inhibit oxidation.

Over time, oxidative stress induces damage of protein, lipid, and cell DNA can lead to the incidences of chronic disease, including heart disease, diabetes, and cancers.

Free radicals are unstable atoms with an unpaired electron in the outer ring. Therefore, in order for them to become stable, free radicals are ready to steal or donate an electron from or to other atoms.

Oxidative stress can be preventable if antioxidants in the body can pair all electrons in the outer ring.

Overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.

Believed it or not, skin aging is a result of the accumulation of damage inflicted by reactive oxygen species (ROS), according to the free radical theory.

In a healthy individual, antioxidant enzymes produced by the body are more than enough to accounter the expression of free radicals occurred in our body every day.

However, in people with a weakened immune system such as elderly, intake of dietary antioxidants such as supplement or fruits rich with antioxidants may be the only option to improve levels of antioxidant in the body.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

With an aim to find a potential compound for the prevention and treatment of diseases associated with oxidative stress, researchers examined the effects of black and navy beans containing non-digestible fermentable components (SCFA precursors) and phenolic compounds (phenolic acids, flavonoids, and anthocyanins) antioxidant and anti-inflammatory activity.

In an animal model, C57BL/6 mice were fed a 20 % navy bean or black bean flour-containing diet or an isoenergetic basal diet (BD) for 2 weeks before the induction of experimental colitis via 7 d dextran sodium sulfate (DSS, 2 % (w/v) in the drinking water) exposure, researchers showed that
* Cooked black and navy bean diet increased caecal SCFA and fecal phenolic compound concentrations (P< 0·05) inhibit the colonic and systemic inflammation.

* Both beans diet reduced mRNA expression of colonic inflammatory cytokines such as IL-6, IL-9, IFN-γ, and IL-17A) and increased anti-inflammatory cytokines such as IL-10.

* Furthermore, systemic inflammatory circulating cytokines (IL-1β, TNFα, IFNγ, and IL-17A, P< 0·05) in the acute and chronic inflammation and biomarkers associated with oxidative stress caused by the injection of dextran sodium sulfate (DSS) are also inhibited by the cooked black and navy beans.

* Unfortunately, both bean diets also are found to enhanc3 DSS-induced colonic damage, according to the increased histological injury score and apoptosis

Based on the findings, researchers suggested that bean-containing diets exerted both beneficial and adverse effects during experimental colitis by reducing inflammatory biomarkers both locally and systemically while aggravating colonic mucosal damage.

In other words, black and navy bean diet inhibit parameters involved in inflammation and oxidative stress and has a negative impact on colitis severity.

Taken altogether, navy beans may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA. (PubMed)

Turmeric Promotes Myeloma Cancer Cells Apoptosis

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Most cases of cancer overtime after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow that produces the white blood cells which are normally responsible for the production of antibodies to protect our body against infection.

Over time, multiple myeloma can lead to the accumulation of cancer cells in the bone marrow, overcrowding out healthy blood cells.

According to the statistics provided by the American Cancer Society, In the US, the lifetime risk of getting multiple myeloma is 1 in 132. In 2019, about 32,110 new cases will be diagnosed including 18,130 in men and 13,980 in women.

The causes of multiple myelomas are unidentified. However certain factors have been found to increase the risk of the conditions, inclduing

* Age
If you are between 50 and 70 years old, you are at higher risk to develop multiple myeloma.

*Gender
Men are more likely to develop multiple myeloma than women.

*Race
Cancer tends to affects blacks more often than whites.

* Previous multiple myeloma
People who previously had been treated with multiple myeloma are at a higher risk to develop it again.

*Exposed to certain chemicals
Increased risk of multiple myeloma if you are exposed to certain chemicals such as occupation.

* Family history
If a direct member of the family has multiple myeloma, the risk of the disease is increased.

* Radiation
Increased risk of cancer if you are exposed to radiation, such as radiation exposure of nuclear accident.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of multiple myeloma,, researchers examined the synergistic apoptotic effects on arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266.

The study included U266 cells cultured with MGN-3 (50 or 100μg/ml) and curcumin (2.5-10μM) for 3 days.

Based on the results of cells differentiation assays, MGN-3 alone or curcumin alone showed a significant anti-proliferation of U266 cells at a dose-dependent inhibition manner.

The synergistic effect was noticed at maximized at 100μg/ml MGN-3 plus 10μM curcumin, according to the analysis of post-treatment by inducing the 87% decrease in cell number and a 2.6 fold increase in the percentage of apoptotic cells.

This effect was also exhibited cell cycle arrest in the G0-G1 phase by a 53% decrease in the percentage of cells.in the G0-G1 phase.

More precisely, the combination exerted a strong activity in the stimulation of pro-apoptosis and inhibition of anti-apoptotic by the decreased and increased expression of Bcl-2 and Bax, respectively.

Collectively, researchers wrote in the final report, "MGN-3 and curcumin synergize in the induction of U266 cell apoptosis".

Taken altogether, turmeric used alone or combined with arabinoxylan rice bran may be considered supplements for the prevention and treatment of multiple myeloma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin-induced promoter hypermethylation of the mammalian target of rapamycin gene in multiple myeloma cells by Chen J1, Ying Y2, Zhu H1, Zhu T3, Qu C1, Jiang J3, Fang B. (PubMed)
(2) Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro by Ghoneum M1, Gollapudi S. (PubMed)

Bromelain Kills Breast Cancer Cells in Vitro

By Kyle J. Norton

Breast cancer is a medical condition characterized by irregular cell growth in the breast tissue due to the alternation of DNA.

Most cases of breast cancer at the early stage start in the cells on the surface of the inner lining of either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At this stage, the patient may first notice as a painless lump in the breast or armpit and most often discovered by herself or her partner.

However, some patients may also experience symptoms of nipple discharge (clear or bloody)
inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and
unusual breast pain or discomfort.

At the advanced stage, besides experiencing symptoms shared commonly with other types of cancer, patients may also notice localized bleeding and severe pain due to the oversize that press on nearby blood vessels and nerves.

According to the U.S. Breast Cancer Statistics, approximately, 1 in 8 U.S. women or 12% will develop invasive breast cancer over the course of her lifetime.

In 2019, an estimated 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer at the early stage is close to 100%.

The causes of breast cancer are not identified. Gender, aging, genetic preposition, family history, never pregnant women and smoking are some breast cancer prevalent risk.

Dr. Bhaskarapillai Binukuma, the lead scientist in the evaluation of diet risk of breast cancer wrote, "Increased consumption of total fat and saturated fat were found to be positively associated with the development of breast cancer".

And, "A moderate inverse association between consumption of n-3 fatty acids and breast cancer risk and a moderate positive association between n-6 fatty acids and breast cancer risk were observed".

In other words, if you are high-fat diet follower, your risk of breast cancer is increased substantially.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient for the treatment of breast cancer, researchers examined the bromelain-functionalized multiple-wall lipid-core nanocapsules (Bro-MLNC-Zn) on breast cancer cell line.

The complex used for the study was formed by a Zn-N chemical bond and a chelate with hydroxyl and carboxyl group.

In human breast cancer cells (MCF-7), the complex at the nanocapsule surface showed an antiproliferative effect by maintaining its proteolytic activity.

Interestingly, Bro-MLNC-Zn showed a reduced dose at 160-folds to exerted a similar effect compared to that of and bromelain solution.

Based on the results, researchers said, "The surface functionalization approach produced an innovative formulation having a much higher antiproliferative effect than the bromelain solution".

In order to reveal more information about bromelain anti-breast cancer activity, researchers investigated the possible synergistic cytotoxic effects of bromelain in combination with cisplatin on MDA-MB-231 human breast cancer cells.

Human MDA-MB-231 cells used in the study were treated with different concentrations (0.24-9.5 µM) of bromelain or cisplatin alone, as well as four different combinations.

According to the results of tested assays, single-agent treatment with cisplatin or bromelain decreases the viability of the MDA-MB-231 cells at 24 and 48 h in a dose- and time-dependent manner.

All combinations displayed synergistic effects against MDA-MB-231 cells at 48 h, particularly with combination 1 (bromelain 2 µM + cisplatin 1.5 µM).

Interestingly, combination 1 also was found to induce breast cancer cells death with a significant decrease in the levels of several apoptotic proteins but an increase of levels of the pro-apoptotic proteins compared with bromelain.

Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast CancerCells (MCF-7) by Oliveira CP1,2, Prado WA3, Lavayen V3, Büttenbender SL3, Beckenkamp A4, Martins BS3, Lüdtke DS3, Campo LF3, Rodembusch FS3, Buffon A4, Pessoa A Jr5, Guterres SS4, Pohlmann AR. (PubMed)
(2) Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro by Pauzi AZ1, Yeap SK2, Abu N1, Lim KL3, Omar AR2, Aziz SA4, Chow AL1, Subramani T1, Tan SG1, Alitheen NB. (PubMed)
(3) Dietary fat and risk of breast cancer by Bhaskarapillai Binukumar

1 and Aleyamma Mathew. (PMC)

Healthy Food Onion ReduceS Risk of Endometrial Cancer

By Kyle J. Norton

The endometrium is the inner lining of the mammalian uterus that is very susceptible to hormone change, particularly in the menstrual cycle.

The endometrium is also a reproductive organ where the implantation takes place. In the absence of periodic hormonal influence, before puberty or following menopause, this tissue has a constant morphology and thickness.

Endometrial cancer, a late adulthood cancer is a medical condition characterized by irregular cells growth that starts in the cell on the surface of the inner endometrial lining of the uterus due to the alternation of cells DNA.

Endometrial cancer is the fourth most common cancer among women worldwide, after breast, lung, and bowel cancer.

According to the statistics provided by the American Cancer Society, in the US, cancer of the endometrium is the most common cancer of the female reproductive organs. In 2019, approximately 61,000 cases of endometrial cancer will be diagnosed.

Most common types of endometrial cancer are
* Adenocarcinomas
Adenocarcinomas accounted for accounts for over 80% of cases of endometrial cancer that begins with irregular cells growth in the surface cells of the inner lining of the endometrium

Women who have an early onset of symptoms of peri-menopause are at a higher risk of adenocarcinomas.

* Uterine sarcoma
Uterine sarcoma, a rare uterine cancer containing malignant cells of the muscle and connective tissue of the uterus, is accounted for only 2 percent of all uterine cancer, including
** Endometrial stromal sarcomas
Endometrial stromal sarcomas are also endometrial cancers originated in the non-glandular connective tissue of the endometrium, with unknown origin.

* Leiomyosarcomas
Leiomyosarcomas is a form of endometrial cancer originated from the smooth muscles of the uterus. Endometrial cancer has a resistant tendency and not very responsive to chemotherapy or radiation.

* Carcinosarcoma
Carcinosarcoma is a type of cancer caused by both epithelial and connective tissues of the uterus.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of endometrial cancer, researchers examined the relationship between onion and garlic intake on endometrial cancer, using data from an Italian case-control study.

According to the data of a multicentre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, the OR of endometrial cancer for successive categories of onion intake were 0.94 for <2 portions/week compared to garlic of 0.89.

The OR of onion intake was decreased to 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, compared to garlic of 0.62.

In other words, onion and garlic showed a significant inverse trend for the risk of endometrial cancer depending on the quality intake per week.

Furthermore, The OR for an increment of one portion (i.e. 80 g) of onions in the risk of endometrial cancer per week was 0.81.

Based on the finding, researchers said, "Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer".

Taken altogether, onion may be considered a remedy for the prevention and treatment of endometrial cancer, pending to the confirmation of the larger sample size and multicenter human study.

Sources
(1) Odds ratio analysis in women with endometrial cancer by Plagens-Rotman K1, Żak E1, Pięta B. (PubMed)
(2) Allium vegetables intake and endometrial cancer risk by Galeone C1, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. (PubMed)
(3) Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton

Friday 23 August 2019

Cranberry, Inhibits the Progression of Chronic Kidney Disease (CKD)

By Kyle J. Norton

The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.

The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.

Futhermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.

Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.

In other words, kidney disease often has no symptoms until at a very advanced stage.

Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in high number in patients with diabetes, high blood pressure and other disorders.

Acute kidney dysfunction or acute kidneys failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidneys dysfunction can be cured if the causes are found.

Most cases of acute kidney dysfunction may be associated with toxin accumulated in the kidney organs, leading to the condition of nephrotoxicity.

Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or overdose of certain medications.

Some researchers suggested that people with diabetes are at an increased risk of chronic kidney disease, particularly in those with hyperglycemia.

The National Kidney Foundation wrote, "Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. The strict control of blood sugar levels and reduction of dietary protein intake are also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of renal disease, researchers examined the effect Vaccinium macrocarpon (Dandelion)and Taraxacum officinale (Cranberry) on spontaneous feline chronic kidney disease.

The study included 34 neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) containing 60-80% hydrolyzed proteins, 20-40% minerals and active substances (Lespedeza spp. 0.0588, Vaccinium macrocarpon 0.0371%, and Taraxacum officinale 0.0231%.) for 90 days.

According to tested analysis, both showed a significant effect on the reduced symptoms.

Cats that received the ND exerted a significant decrease of creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase. The elevated levels of the aforementioned parameters have been found persistently in patients with chronic kidney disease.

Furthermore, urine turbidity score, color score, and total proteins associated with the progression of CKD in cats that received the ND were also decreased substantially.

Collectively, researchers after taking other factors into account said, "An ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CKD, particularly in the combination with dandelion and Lespedeza spp, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberries - potential benefits in patients with chronic kidney disease by de Almeida Alvarenga L 1, Borges NA, Moreira LSG, Resende Teixeira KT, Carraro-Eduardo JC, Dai L, Stenvinkel P, Lindholm B, Mafra D. (PubMed)
(2) A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease by Di Cerbo A1,2, Iannitti T3, Guidetti G4, Centenaro S4, Canello S5, Cocco R. (PubMed)
(3) DIABETES AND CHRONIC KIDNEY DISEASE by The National Kidney Foundation

Broccoli Protects the Pancreatic Tissue Damage Induced by Oxidative Stress

By Kyle J. Norton

Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radical that cannot be stopped.

In other words, overexpression of free radicals and depletion of antioxidants are the major cause of oxidative stress.

More precisely, oxidative stress is a result of a long-term imbalance of the ratio of free radicals and antioxidant produced by the host.

Free radicals are highly reactive atoms with a single unpaired electron in an outermost shell with a function to donate or intercepts an electron from other stable atoms, leading to a chain reaction that induces oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA and RNA,..,

Antioxidants are stable atoms that inhibit oxidation.

Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.

Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.

In a healthy individual, antioxidants produced by the body are good enough to prevent the onset of oxidative stress. However, im people with a weakened immune system, intake of dietary antioxidants such as supplements of antioxidant-rich food may be necessary.

Dr. Biller-Takahashi JD, the lead scientist at the joint study led by the UNESP Univ Estadual Paulista wrote, "short-term supplementation with 0.6 mg Se-yeast kg(-1) reestablished the antioxidative status, allowing the production of innate components which can boost immunity without the risk of oxidative stress".

Broccoli is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

On findings a potent and natural compound to prevention pancreatic tissue damage in diabetes, scientists investigated the potential hypoglycaemic and antioxidant properties of aqueous broccoli extracts (BEs) in diabetic rats.

Rats selected to the study induced diabetes by a single intraperitoneal injection dose of 50 mg/kg body weight of Streptozotocin (STZ) drug were co-administration with or without BEs.

After 8 weeks, based on the blood analysis, diabetic rats without co-administration with BEs showed significantly higher levels of pancreatic cells DNA damage, depletion of levels of antioxidant GSH and impaired antioxidant capacity (TAC) levels, compared to non-diabetics.

Furthermore, diabetes rat without co-administration with BEs also demonstrated significant pancreatic tissues damage.

Diabetes rats with BEs co-administration not only reduced all parameters expression but also protected the pancreatic tissue against histopathological changes.

In other words, BEs reduced the damage of pancreas tissue caused by STZ induced hyperglycemia and oxidative injury by enhancing the production of antioxidant enzymes in the tested rats.

Based on the findings, researchers said, "The used in vivo model confirmed the efficacy of BE as an anti-diabetic herbal medicine and provided insights into the capacity of BE to be used for phytoremediation purposes for human type 2 diabetes".

Taken altogether, broccoli may be considered a functional food for the prevention of oxidative stress-induced pancreatic tissue damage, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli (Brassica oleracea) Reduces Oxidative Damage to Pancreatic Tissue and Combats Hyperglycaemia in Diabetic Rats by Suresh S1, Waly MI1, Rahman MS1, Guizani N1, Al-Kindi MAB2, Al-Issaei HKA2, Al-Maskari SNM3, Al-Ruqaishi BRS3, Al-Salami A. (PubMed)
(2) The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus by Biller-Takahashi JD1, Takahashi LS2, Mingatto FE3, Urbinati EC. (PubMed)

Herbal Ashwagandha Arrests Prostate Cancer In Vitro

By Kyle J. Norton

Cancer is a group of chronic diseases caused by irregular cell growth in the specific tissue of an organ due to DNA alternation.

Most cases of cancer start in the cell of the surface of the inner lining tissue before penetrating into deeper layers to form a tumor.

However, as cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cell can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of an enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction, blood in the urine and blood in the seminal fluid.

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome and genetic proposition are some prevalent factors found in patients with the condition.

Conventionally, treatments of prostate cancer are totally depending on the type, stage, and grade accompanied by the patient overall health, age and life expectancy.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

Researchers on finding a potent and natural ingredient for the treatment of prostate cancer investigated the effects of Withania extracts on highly metastatic, androgen-independent prostate cancer cell line (PC3).

According to the results obtained from tested differentiation, the extracts demonstrated strong inhibitory activity in decreasing the cancer cell viability with a half-maximal inhibitory concentration (IC50) of 10 μg/mL.

The sample of prostate tissue and in PC3 cells also exhibited the predominantly high expression levels of IL-8 associated with the production chemokine produced by macrophages and COX-2 involved in the contribution of immune evasion and resistance to cancer immunotherapy were also suppressed by the lowest dose of W. somnifera in 24 hours.

Furthermore, the extract induced cycle arrest of the cancer cell line at the cell cycle in G2/M phase, observed from the rapid accumulation of PC3 cells significantly.

Moreover, W. somnifera extracts suppressed the PC3 inherent metastatic activity.

Based on the results, researchers wrote, "W. somnifera may be a good therapeutic agent in addition to the existing drugs for PC".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of prostate cancer, pending to the confirmation of larger size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells by Rehman S1, Keefover-Ring K2, Haq IU3, Dilshad E4, Khan MI5, Akhtar N6, Mirza B. (PubMed)
(2) Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression by Setty Balakrishnan A1, Nathan AA1, Kumar M1, Ramamoorthy S2, Ramia Mothilal SK. (PubMed)