Herbal Turmeric Protects the Neurons Function Against Parkinson's disease,

By Kyle J. Norton

Dementia is a medical and neurodegenerative disease characterized by the loss of mental ability, that is severe enough to interfere with people's every life including Alzheimer's disease and Parkinson's disease (PD), the most common types of dementia in aging people.

Dementia accounts for 5-8% of all people over the age of 65, and this number doubles every five years.

Parkinson's disease (PD) is a type of dementia that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.

In other words, Parkinson's disease is a progressive neurological disorder that affects neurons in transmitting messages in controlling the movement.

In the very early stage of PD, patients may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.

As of today, researchers do not know why the neurons in the brain in some people are susceptible to gradually break down or die while others do not even they have similar health conditions and from the same family.

 Epidemiologically aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the prevalent factors involved in the increased risk of the disease.

Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink green tea regularly, are less likely to get Parkinson's disease compared to those who don't.

Dr. Jurado-Coronel, the lead scientist at the Pontificia Universidad Javeriana wrote, wrote, "This (green tea) beverage is prepared from the leaves (steamed and dried) of the Camellia Sinensis plant and contains strong antioxidant and neuroprotective phenolic compounds from which the most important is (-)-Epigallocatechin-3-gallate"

And, " Parkinson's disease (PD) is the second more common neurodegenerative disorders, after Alzheimer's disease and is characterized by degeneration of dopaminergic neurons in the pars compacta of the substantia nigra of the basal ganglia. It has been shown in pre-clinical and clinical studies that green tea may be able to prevent PD".

The results strongly suggested if you drink green tea, your risk of PD is decreased substantially.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potent ingredient for the treatment of neurological disease, researchers examined the effects of Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa on Parkinson's disease (PD) in an animal model.

According to the 13 studies with a total of 298 animals describing the efficacy of curcumin in animal models of PD were selected by searching the online medical literature,

* The majority of the experimental studies suggested that curcumin processes significant neuroprotection for the treatment of PD compared to control group.

* 5 selected studies indicated that curcumin had an anti-inflammatory effect in the PD animal models.

* Furthermore, , four studies suggested that curcumin processes antioxidant capacity in the protection of substantia nigra neurons and improvement striatal dopamine levels in PD animal model.

* Additionally, two studies also displayed that curcumin treatment was also effective in reducing neuronal apoptosis and improving functional outcome in animal models of PD.

Based on the findings, researchers said, "Most of the preclinical studies demonstrated the positive findings while one study reported that curcumin had no beneficial effects against Mn-induced disruption (induced neurotoxicity) of hippocampal metal and neurotransmitter homeostasis"

And, "The results demonstrated a marked efficacy of curcumin in an experimental model of PD, suggesting curcumin probably a candidate neuroprotective drug for human PD patients".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Parkinson's disease (PD), pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chronic dietary supplementation with turmeric protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-mediated neurotoxicity in vivo: implications for Parkinson's disease by Mythri RB1, Veena J, Harish G, Shankaranarayana Rao BS, Srinivas Bharath MM. (PubMed)
(2) Neuroprotective properties of curcumin in toxin-base animal models of Parkinson's disease: a systematic experiment literatures review by Wang XS1, Zhang ZR1, Zhang MM1, Sun MX2, Wang WW3, Xie CL. (PubMed)
(3) The implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease by Jurado-Coronel JC, Ávila-Rodriguez M, Echeverria V, Hidalgo OA, Gonzalez J, Aliev G, Barreto GE. (PubMed)

Onion, a Natural Treatment of Endothelial Dysfunction

By Kyle J. Norton

The endothelium is the lining of the interior surface of blood vessels and lymphatic vessels. In other words, endothelium formed an interface to separate the circulating blood or lymph in the lumen and the rest of the vessel wall.

The endothelium processes some main functions, inclduing acting as a semi-selective barrier between the vessel lumen and surrounding tissue and transporting white blood cells into and out of the bloodstream.

Endothelial dysfunction is a medical condition that reduces the function of the endothelium caused by the failure of the endothelial inner lining of the small arteries to function normally, affecting the cardio-functioning.

Epidemiologically, endothelial dysfunction has been found to induce cardiovascular conditions, including coronary artery disease (CAD), hypertension, and diastolic dysfunction.

The causes of endothelial dysfunction are associated with a low level of free radical NO that modulates vascular tone and endothelial function.

Endothelial dysfunction caused by reduced levels of NO in the body induces excess vasoconstriction of blood vessels, increases the risk of platelets activation and inflammation of the arterial wall and stimulates lipid peroxidation, leading to the complications of hypertension and coagulation.

Dr. Tousoulis D, the lead scientist wrote, " This substance (Nitric oxide (NO)) ....has a wide range of biological properties that maintain vascular homeostasis, including modulation of vascular dilator tone, regulation of local cell growth, and protection of the vessel from injurious consequences of platelets and cells circulating in blood, playing in this way a crucial role in the normal endothelial function'.

And, "A growing list of conditions (associated with reduced levels of NO), including those commonly associated as risk factors for atherosclerosis such as hypertension, hypercholesterolemia, smoking, diabetes mellitus, and heart failure are associated with the diminished release of nitric oxide into the arterial wall either because of impaired synthesis or excessive oxidative degradation".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of endothelial dysfunction researchers examined the effect of consumption of onion peel extract (OPE) on endothelial function in healthy overweight and obese individuals.

72 healthy overweight and obese participants included in the randomized double-blind, placebo-controlled study were randomly assigned to receive a red, soft capsule of OPE (100 mg quercetin/d, 50 mg quercetin twice daily; n = 36 participants) or an identical placebo capsule (n = 36) for 12 weeks.

According to the tested analysis and compared with baseline values, the OPE group showed significantly improved flow-mediated dilation (FMD) associated with increased blood flow in the artery at 12 wk, from 12.5 ± 5.2 to 15.2 ± 6.1, compared to the placebo group.

Furthermore, the circulating endothelial progenitor cells (EPCs) involved in the cells of bone marrow that enter the vasculature by circulating angiogenic factors were significantly increased in the OPE group, compared to no change in the placebo group.

In the OPE group, there was no change of nitroglycerin-mediated dilation associated with impaired arterial dilatation response compared to the placebo group.

In the comparison of the endothelial dysfunction on the lowest quartile (cutoff value, 8.6%), the FMD  improved from 26% to 9% by OPE.

These results display a strong effect of OPE in the promotion of endothelial function through many aspects of the overweight and obese participants.

Based on the results, researchers suggested, "Medium-term administration of OPE an improvement in FMD and circulating EPCs".

Taken altogether, onion processed a higher mount of onionin A (ONA) may be considered a remedy for the prevention and treatment of endothelial dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial by Brüll V1, Burak C1, Stoffel-Wagner B2, Wolffram S3, Nickenig G4, Müller C4, Langguth P5, Alteheld B1, Fimmers R6, Naaf S7, Zimmermann BF7, Stehle P1, Egert S. (PubMed)
(2) Effect of onion peel extract on endothelial function and endothelial progenitor cells in overweight and obese individuals by Choi EY1, Lee H2, Woo JS1, Jang HH1, Hwang SJ1, Kim HS1, Kim WS1, Kim YS3, Choue R2, Cha YJ4, Yim JE4, Kim W. (PubMed)
(3) The role of nitric oxide on endothelial function by Tousoulis D1, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C. (PubMed)

Ashwagandha, The Anti-Aging Functional Herb In Men

By Kyle J. Norton

Aging is a natural process of getting older. Antiaging is a term that refers to slow down the aging process. In other words, anti-aging is an action that makes your appearance that looks younger than your biological age, inclduing the use of herbal medicine.

What causes aging? The question that has been asked throughout human history. While many theories try to answer the question by related aging to tear and wear of the body, others deal with how the organs and systems in the body develop and deteriorate over time, etc..

The antioxidant theory suggested that the accumulation of damage due to oxidative stress over a long-term can initiate DNA oxidation, leading to DNA methylation.

In hormonal theory, the decrease in hormone production gradually found in the human body may contribute to a major cause of aging progression.

In other words, reduced production of hormone affects the amount of hormone released into the bloodstream, leading to decreased functioning of the target organs and systems.

The somatic mutation theory even suggested aging is due to the inherited genes that come directly from the parents. Lifelong exposures to toxins, radiation or ultraviolet light, artificial ingredients, and unhealthy lifestyle, can increase the risk of cells mutation, leading to incorrectly DNA coping.

Some researchers suggested that improved nutrients intake may have a strong effect in delaying the progression of aging and reducing the risk of age-related diseases.

Dr. D. Marsman and colleagues wrote, "New clinical studies of healthy aging are needed and quantitative biomarkers are an essential component, particularly tools which can measure improvements in physiological integrity throughout life, thought to be a primary contributor to a long and productive life (a healthy “lifespan”).


And, "A framework for progress has recently been proposed in a WHO report which takes a broad, person-centered focus on healthy ageing, emphasizing the need to better understand an individual’s intrinsic capacity, their functional abilities at various life stages, and the impact by mental, and physical health, and the environments they inhabit.".

The results strongly suggested that if you follow a healthy diet with plenty of nutrients by focusing on calories, macronutrients, you may delay the process of biological aging.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent anti-aging compound, researchers examined the effects of Ashwagandha ( Withania somnifera) in the promotion of youthful vigor, including fatigue, vigor, and steroid hormones in aging men.

The randomized, double-blind, placebo-controlled, crossover study included overweight men aged 40-70 years, with mild fatigue given a placebo or an ashwagandha extract (Shoden beads, delivering 21 mg of withanolide glycosides a day) for 8 weeks.

According to the tested analysis of 50 people completing the first 8-week period of the trial and 43 completing all 16 weeks, ashwagandha extract-treated group showed improvements in fatigue, vigor, and sexual and psychological well-being.

Furthermore, Ashwagandha intake demonstrated an 18% greater increase in DHEA-S and 14.7% greater increase in testosterone, compared to the placebo without affecting levels of cortisol and estradiol.

In other words, Ashwagandha increased the levels of male hormones compared to placebo.

Based on the finding, researchers concluded, " the intake of a standardized ashwagandha extract (Shoden beads) for 8 weeks was associated with increased levels of DHEA-S and testosterone, although no significant between-group differences were found in cortisol, estradiol, fatigue, vigor, or sexual well-being".

Taken altogether, Ashwagandha may be used as an anti-aging functional herb, pending to the results from the large sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males by Lopresti AL1,2, Drummond PD1, Smith SJ. (PubMed)
(2) Healthy ageing: the natural consequences of good nutrition—a conference report by D. Marsman,1 D. W. Belsky,2 D. Gregori,3 M. A. Johnson,4 T. Low Dog,5 S. Meydani,6S. Pigat,7 R. Sadana,8 A. Shao,9 and J. C. Griffiths. (PMC)

Phytochemical Betacyanins Inhibits the Parameters Which Cause the Onset of Cognitive Deficit

By Kyle J. Norton

Cognitive deficit is a medical condition associated with the impairment of a person's mental processes and the ability to acquire information and knowledge that interact with the outside world.

Most common causes of cognitive deficit include the genetic preposition, birth defects that affect the central nervous system such as Down syndrome and fragile X syndrome, malnutrition, prematurity, and conditions that were caused decreased oxygen to the brain.

Some researchers suggested that age degeneration, neurons injury that causes the death of some neurons involved in cognition, brain cancer in the cognitive region and environmental factors also associated with the risk of cognitive deficit.

Some early signs and symptoms of cognitive deficits may include signs of global developmental delay in childhood such as language, walking, self-care skills, and/or imitative play, delay cognitive skill compared to the most children in the same age, particularly difficult in performing of school works.

If your child has some of the social, adaptive, cognitive, language, gross motor and fine motor problem, please check with his/her doctor to rule out the possibility of cognitive deficit.

As of today, there is no cure for the cognitive deficit. The aim of the treatment is to improve the quality of life and reduce symptoms and delay the progression of the diseases.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential and natural ingredient for the treatment of cognitive deficit, researchers assessed the protective effect of betacyanins isolated from Portulaca oleracea L. against the D-galactose (D-gal)-induced neurotoxicity in mice.

Based on the behavioral tests, D-galactose (D-gal)-induced neurotoxicity in mice treated by betacyanins showed a strong effect on the improvement of learning and memory impairments.

Additionally, the levels of brain antioxidant levels such as superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in D-gal-treated mice were significantly increased by the injection of betacyanins.

Furthermore, lipid peroxidation product found in the brain tissues and neurons such as malondialdehyde (MDA) was decreased by betacyanin administration.

Moreover, levels of the activities of SOD, CAT GR, and GPx in the mouse brain, had a significant negative correlation compared to the positive correlation of the level of MDA with the mouse cognitive impairment.

In other words, oxidative stress caused by D-galactose (D-gal)-induced neurotoxicity induced low levels of antioxidants enzymes such as SOD, CAT GR and GPx in the mouse brain were restored by the injection of betacyanins.

Based on the finding, researchers wrote in the final report, "These results suggest that the neuroprotective effect of betacyanins against D-gal-induced neurotoxicity might be caused, at least in part, by an increase in the activities of antioxidant enzymes with a reduction in lipid peroxidation" and "the betacyanins had a more pronounced effect on ameliorating cognition deficits in mice".

Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of cognition deficits, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)

Cucumber, The Best for the Treatment of Hyperlipidemia, According to Human Trial

By Kyle J. Norton

Hyperlipidemia is a condition of abnormally high blood lipid in the bloodstream a major cause of plaque accumulation on the arterial wall that leads to the increased risk of heart disease and stroke.

Cholesterol produced either by the liver or fat intake is essential to aid the digestive system in digesting foods and absorbing nutrient before passing them to other parts of the body, build a strong cell wall, produce vitamin D and steroid hormone.

There are 2 main types of cholesterol. The low-density lipoprotein (LDL) which carries the aforementioned function and the high-density lipoprotein (HDL)which returns the cholesterol back to the liver for reuse in the future.

The healthy blood cholesterol ratio of total blood cholesterol of LDL/ HDL is any numbers that are less than 4.

People with high blood cholesterol are asymptomatic. Conventionally, the condition can be lowered by regular intake of blood cholesterol-lowering medicine.

Most common risk factors that cause the onset of high blood cholesterol are unhealthy diet and physical inactivity.

Some researchers in the examination of the widespread high blood cholesterol over the past few decades probably are associated with the promotion of the high-fat diet in the US.

Dr. Cole TG, the lead scientist wrote," In normals, dietary cholesterol increases LDL production and decreases LDL receptor-related LDL clearance, resulting in elevations in LDL cholesterol levels of approximately 30 mg/dL".

Therefore, by changing behaviors in lifestyle, you may just be doing fine without medication. Please sure you tale to your doctor before withholding.

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural compound for the treatment of hyperlipidemia with no side effects, researchers examined the efficacy of Cucumber (Cucumis sativus) seed, used traditionally as a lipid-lowering nutritional supplement.

The randomized double-blind placebo-controlled clinical trial included hyperlipidemic patients with inclusion criteria randomly and equally assigned to either Cucumis or placebo groups or one medicinal or placebo capsule, once daily with food for 6 weeks.

According to the tested assays obtained from 23 patients in Cucumis group and 23 patients in the placebo group completed the study, cucumber seed extract treated group showed a significant reduction of total cholesterol, and BMI index compared to baseline taken before the treatment

The extract also increased the levels of high-density lipoprotein (HLD) compared to placebo.

More precisely, at a concentration of daily dose of 500 mg, the consumption of C. sativus seed extract daily, exerted strong effects on serum lipid profile in tested adult hyperlipidemic patients.

In other words, daily injection at the ceratin dose may have a desirable effect in the prevention of hyperlipidemia in facilitating the onset of cholesterol build-up on the arteries and risk of cardiovascular disease.

Based on the results, researchers said, "Cucumber seed could be considered as a food supplement for treatment of dyslipidemia".

Taken altogether, cucumber may be used for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of the Effects of Cucumis sativus Seed Extract on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial by Soltani R1, Hashemi M2, Farazmand A1, Asghari G3, Heshmat-Ghahdarijani K2, Kharazmkia A4, Ghanadian SM. (PubMed)
(2) Effects of high cholesterol high fat diet on plasma lipoproteins in familial hypercholesterolemia by Cole TG, Pfleger B, Hitchins O, Schonfeld G. (PubMed)

Herbal Ginger, the Best Chemo Preventive Functional Food

By Kyle J. Norton

Scientists may have found a natural ingredient which processed chemopreventive effects, with no side effects, according to study.

Chemoprevention is a general term used to describe the use of nontoxic natural chemicals and supplements for the treatment of cancer without inducing side effects.

The subjects of chemoprevention have under intensive studies over the last many years due to the side effects of chemo drugs. Natural chemopreventive agents have emerged as a promising and pragmatic medical approach to reduce the risk of cancer.

Most natural chemical compounds have been found to process the activity similar to those of conventional medicines for the treatment of cancer such as antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest.

For example:

Curcumin found in turmeric in animal models has been shown to protect against skin, oral, intestinal, and colon carcinogenesis and also to suppress angiogenesis and metastasis.

Furthermore, the administration also found that the chemical compound process the ability to cancer proliferation by cell cycle arrest, induced apoptosis and activated the phase carcinogen-detoxifying enzymes.

Moreover, curcumin has a capability to inhibit carcinogen bioactivation via suppression of specific cytochrome P450 isozymes associated with the biotransformation of medication that causes drug toxicities, reduced pharmacological effect, and adverse drug reactions.

Dr. Pan MH the lead scientist in the cancer team at the National Kaohsiung Marine University wrote,  "Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds".

And, "In this critical review, we will summarize current knowledge on natural dietary compounds that act through the signaling pathways and modulate gene expression to induce detoxifying enzymes, programmed cell death, anti-inflammatory, and anti-proliferative effects, thus providing evidence for these substances in cancer chemopreventive action".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural ingredient which processes chemopreventive effects with no side effects, researchers examined the ginger effect on cancer prevention.

Ginger exerted a significant activity against cancer onset through several mechanisms, including free radical scavenging, antioxidant pathways, alteration of gene expressions, and induction of apoptosis.

Ginger protects the integrity and viability of the cell by decreasing tumor initiation, promotion, and progression.

Dr. Baliga MS, the lead scientist,. after taking other factors into accounts wrote, "The above-mentioned mechanisms of ginger seem to be promising for cancer prevention; however, further clinical studies are warranted to assess the efficacy and safety of ginger".

In order to reveal more information about the ginger anticancer activity, researchers evaluated the effects of  [6]-gingerol aspirinate (GAS) against colorectal cancers.

GAS exerts enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice by inhibiting the protein associated with the production of proinflammatory cytokines.

More importantly, GAS was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release of [6]-gingerol. 

Dr. Zhu Y, the lead researcher said, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".

Take all together, ginger processed high amounts of the bioactive compound may be considered a functional alternative for chemoprevention, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Update on the chemopreventive effects of ginger and its phytochemicals by Baliga MS1, Haniadka R, Pereira MM, D'Souza JJ, Pallaty PL, Bhat HP, Popuri S. (PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)
(3) Chemopreventive effects of natural dietary compounds on cancer development by Pan MH1, Ho CT. (PubMed)

(4) Cancer chemopreventive effects of curcumin by Surh YJ1, Chun KS. (PubMed)

Herbal Bilberry, the Best in the Prevention and treatment of Type 2 Diabetes

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a whole berry for the treatment of type 2 diabetes, according to studies.

Type 2 diabetes is a medical condition caused by not enough insulin entering the bloodstream to convert blood glucose into energy. Insulin resistance is a hallmark of patients with the disease.

Insulin is a hormone with a function to regulate the movement of sugar into your cells. In other words, insulin converts sugar to energy to fuel the body needs.

Most cases of type 2 diabetes is a result of not enough insulin produced by the pancreas due to reduced numbers of healthy beta cells or the insulin produced was not used properly due to the clogged up of the insulin receptor sites.

 Type 2 diabetes is an acquired disease in adulthood. In the Western world, most cases of type 2 diabetes are associated with obesity induced by a long-term poor diet and lack of exercise.

Truly enough, over 68% of the population in the US are either overweight or obese.

According to the statistics in the US, in 2015, 30.3 million Americans or 9.4 percent of the U.S. population and another 84.1 million had confirmed diabetes and prediabetes, respectively.

Sadly, the majority of people with prediabetes don't know they had it.

Therefore, losing weight, eating well and moderate exercise daily can help to manage the disease against the onset of hyperglycemia, a major cause of the diabetic complication.

People with type 2 diabetes who can not manage the disease through weight loss, healthy diet and exercise are commonly treated with medications or insulin therapy.

Please make sure you know all the side effects if you are currently taking any form of therapies for diabetic treatment.

Most common symptoms of type 2 diabetes depending on the severity of the stages include increased thirst, frequent urination, unintended weight loss, and fatigue,

In severe cases, patients may also experience symptoms wound that does heal, blurred vision and frequent infections and areas of darkened skin.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

On finding potential ingredients from the treatment of type 2 diabetes, researchers examined the bilberry content of anthocyanins and polyphenols which have been proven to process antidiabetic activity in several studies.

Injection of anthocyanins and polyphenols exhibited an increase in insulin secretion (anthocyanin pelargonidin), reduction of insulin resistance (anthocyanin cyanidin-3-glucoside), and glucose resorption from the GIT (polyphenols) and enhancement of beta-cells regeneration associated with the diabetics.

In the examination of the single ingredient anthocyanins, researchers found the compounds also contribute to the improvement of the lipid spectrum compared to that of acarbose and atorvastatin, according to many preclinical and clinical studies.

Furthermore, the compound derivatives anthocyanin cyanidin-3-galactoside also have antioxidant, anti-inflammatory and cardioprotective activities.

In order to reveal more information about bilberry antidiabetic effects, researchers at the joint study led by the University of Eastern Finland differentiated the serum hippuric acid changes after intake of bilberry.

In a total of 47 individuals with features of the metabolic syndrome, randomly assigned to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12).comapred to from fasting serum samples at baseline and after an 8-week intervention, researchers showed that fasting serum hippuric acid increased significantly (3.5-fold) only in the BB group and correlated with changes in fasting plasma glucose concentration and insulin secretion.

These results suggested bilberry anti-diabetic property not only confirms the Finnish Diabetes Prevention Study but also improves glycemic control and pancreas β-cell function which is reduced in patients with type 2 diabetes.

Dr. the lead scientist wrote after taking into account co and confounders in the final report, "Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a function remedy for the treatment of type 2 diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes by de Mello VD1, Lankinen MA1, Lindström J2, Puupponen-Pimiä R3, Laaksonen DE4, Pihlajamäki J1,5, Lehtonen M6,7, Uusitupa M1,8, Tuomilehto J2,9,10, Kolehmainen M1, Törrönen R1, Hanhineva K. (PubMed)
(2) [Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitusBillberry (Vaccinium myrtillus)].[Article in Czech] by Koupý D, Kotolová H, Kučerová J. (PubMed)