How to Protect Pancreatic Islet (β-cells and Size of Islet) Against Onset of Diabetes Naturally, Medline Model Studies Reveal

Kyle J. Norton


Chaste tree berry may have a potential in stimulated pancreatic islet regeneration in reduced risk of development and treatment of Type I and II diabetes, some researchers suggested..

Diabetes is a condition characterized by insufficient insulin entering the bloodstream in regulation of levels of glucose.

The disease are either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

 In some cases, diabetes is also caused by allergic reaction of cells in the immune system.


Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the study, diabetes rats induced by streptozotocin treated with extract of chaste tree berry displayed a significant effect in increased volume density of pancreatic islet as well as percentage of β-cells and size of islet.

Decrease volume and weight of pancreatic islet is associated to juvenile-onset, insulin-dependent diabetes.
Percentage of β-cells are greatly reduced already at clinical onset of type II diabetes.

However, reduction of numbers of β-cells are more moderate than in insulin-dependent juvenile-onset diabetic subjects and in some case it does not account for the disease.

And, altered islet composition and disproportionate loss of size of islet are associated linearly to patients with type II diabetes.

Pancreatic islets are the regions of the pancreas containing hormone-producing cells,

Dr. Oche O, the lead researcher said, "plant extracts, (exhibited) regeneration of β-cells along with β-cells repairs, in compared to non-treated diabetic control which showed complete degeneration of the islet cells".

Furthermore, the study also found that the levels of total bilirubin, direct bilirubin and unconjugated bilirubin are significantly lower in treated group in comparison to control.

In compared to healthy control, the median bilirubin level was significantly higher in the diabetes. 


More important, in D-galactose induces pancreatic disorder along in aging mouse model, treatment of Vitex agnus-castus (VAC) demonstrated potential pancreatic protective and hypoglycemic effects through improved the size of pancreatic islets that were decreased in aged and D-galactose groups.

Galactose D is a type of monosaccharide sugar, considered as sweet as glucose.

In a total of 72 adult female Naval Medical Research Institute (NMRI) mice (weighing 30-35 g) divided into 6 groups: control, VAC hydroalcoholic extract, D-galactose, D-galactose + VAC hydroalcoholic extract, aged, aged + VAC hydroalcoholic extract through subcutaneous injection of D-galactose for 45 days and then VAC hydroalcoholic extract gavaged twice a day in the last 7 days.


24 h after the last drug and extract administrations, group treated with Chaste tree berry extract or combinations of the extract showed an increased insulin and decreased serum glucose and D-galactose level in compared to other treatment groups.


The study also found, "Despite the size of pancreatic islets decreased in aged and D-galactose groups, ........... VAC hydroalcoholic extract has hypoglycemic and pancreatic protective effects in natural aged and aging model mice".


In fact, there is a report indicated that oral administration of iridoid glucoside isolated from chaste tree berry once daily to diabetic rats for the period of 30 days is effective as glibenclamide, a known hypoglycemic drug, at concentration of 50 mg/kg body weight.

Promissingly, iridoid glucoside reversed hyperglycemia-induced biochemical changes to near normal levels.

Collectively, Chaste tree berry may be used as functional food for treatment of Type I and Type II diabetes through the hypoglycemic and pancreatic protective effects.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its antidiabetes possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pancreatic islet regeneration and some liver biochemical parameters of leaf extracts of Vitex doniana in normal and streptozotocin-induced diabetic albino rats by Oche O1, Sani I1, Chilaka NG1, Samuel NU1, Samuel A1.(PubMed)
(2) Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model by Ahangarpour A1, Oroojan AA2, Khorsandi L3, Najimi SA4.(PubMed)
(3) Antihyperglycemic effect of iridoid glucoside, isolated from the leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference to glycoprotein components by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(4) The pancreatic islets in diabetes by Gepts W, Lecompte PM(PubMed)

How to Improve Your Digestive Functioning Naturally, MEDLINE Studies Suggest

Kyle J. Norton

Fennel may have a therapeutic and enhanced effect in improve digestive system in absorbed nutrients and fluids from foods intake, some scientists suggested.

The result of this efficacy was published online by several respectable institutes, including the University of Illinois at Chicago and Afyon Kocatepe University.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.


According to the study, researchers set out a criteria and guideline to investigate the effect of fennel in gram-negative bacterium Helicobacter pylori (HP), the microorganisms has been associated with the development of gastritis and peptic ulcer disease to confirm the theory of used in traditional medicine fennel to treat a wide range of ailments, including gastrointestinal (GI) disorders such as dyspepsia, gastritis and peptic ulcer disease (PUD), application of methanol extracts of botanicals with a MIC of 50 microg/mL included Achillea millefolium, Foeniculum vulgare (seed), exerted a significantly inhibitory effect against all susceptibility of 15 HP strains.

These results suggested that injection of fennel displays a potential effect in balanced the ratio of micro organisms in the gastrointestinal tract, thus improving the function in absorbed and distributed nutrients to the body.

These properties reassured the herbal medicine used in practice for treatment of numbers symptoms of digestive disorder.

Furthermore, in animal model with rat induced gastric lesions induced by injection of ethanol, application of aqueous extracts of Foeniculum vulgare (FVE) showed a strong activity in inhibited the ulcerogenic expression through its antioxidant activities..

In observation of the efficacy of 60 minutes pre administration of the doses of fennel extracts at 75, 150 and 300 mg/kg, with famotidine, histamine H₂ receptor antagonist with function to inhibit stomach acid production at the dose of 20 mg/kg, before injection of ethanol, researchers found that

* Pre treatment of all doses exert significant gastric protective effects in reduced injure and damage caused by injection of ethanol.

* Fennel extract demonstrates a theurateutic activity linearly in compared to other doses and control at dose of 300 mg/kg 

* These activities was associated to reduce the malondialdehyde (MDA) levels, a marker in expression of severe levels of oxiadive stress.

Additional analysis, also suggested that fennel stimulated gastro-protect effect through its antioxidants and facilitated production of antioxidants in the body tissues in inhibited the over expression of free radicals, thus maintaining the ratio of micro organisms in the digestive tract and its functioning.

After, taking into account of other co and con founders, researchers also suggested that the results in part may also be attributed to antioxidant in ameliorated lipid peroxidation.

The above differentiation were supported by the joint report lead by the Joint Keio University, in the investigation of fennel properties in associated to functional dyspepsia (FD), a functional gastrointestinal disorder characterized by persistent or recurrent postprandial upper abdominal discomfort and epigastric pain.

Truly, delayed gastric emptying and impaired gastric accommodation was found to play important roles in the development of FD. 

Anethole (1-methoxy-4-((E)-propenyl)-benzene), a major component of fennel essential oil, in rodents exerted a huge effect in improved clonidine-induced delayed gastric emptying, orally.

Also, application of fennel oil plus Anchu-san (a Japanese herbal medicine containing anethole)  demonstrated an important activity in reduced risk of functional dyspepsia (FD) through restoring the delayed gastric emptying.

In other words,  anethole processes a gastro protective efficacy through stimulating gastric accommodation. 

Taken together, whole fennel, fennel essential oil and its bioactive compound anethole may be used as secondary application in reduced risk and treatment of digestive disorder.

Adding a portion of fennel in your diet may improve the digestive function in absorption nutrients and fluids from the food intake.

However, intake of supplement should be taken with extreme care as overdose may cause acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders by Mahady GB1, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR.(PubMed)
(2) Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats by Birdane FM1, Cemek M, Birdane YO, Gülçin I, Büyükokuroğlu ME.(PubMed)
(3) Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents by Asano T1, Aida S2, Suemasu S2, Mizushima T3.(PubMed)

How to Maintain A Healthy Skin, Naturally and Permanently, PubMed Studies Find

Kyle J. Norton

Tomatoes may have a profound and positive effect in improved skin health, some scientists suggested.

The results of analysis were carried out by several universities and research companies, including IUF - Leibniz Research Institute for Environmental Medicine and published on numbers of online literature.


Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A
6. Vitamin B1
7. Vitamin B2
8. Vitamin B3
9. Vitamin B5
10. Vitamin B6
11. Folate
12. Vitamin C
13. Vitamin E
14. Molybdenum
15. Magnesium
16. Manganese
17. Copper
18. Potassium
19. Chromium

In the aim to reaffirm tomatoes effect in reduced negative impact against ultraviolet (UV)A/B and UVA1 radiation at a molecular level, scientists at the IUF - Leibniz Research Institute for Environmental Medicine launched a study of the tomato bioactive compounds lutein and lycopene photoprotective effect on human skin health.

The purpose of the study was to assess the two active treatments containing either lycopene (TNC) or lutein to test for their capacity in decreased expression of UVA1 the radiation-inducible genes HO1, ICAM1 and MMP1

Gene heme oxygenase 1 (HO1) is an enzyme with function to to protect cells from oxidative damage, in this case it was the UVA1

Gene intercellular adhesion molecule 1 (ICAM1) also known as CD54 (Cluster of Differentiation 54) is a protein with function in adhesion phenomena involved in the immune response.

Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme with function to break down collagens located in the ECM.

The placebo-controlled, double-blinded, randomized, crossover study included 65 healthy volunteers allocated to four treatment groups and subjected to a 2-week washout phase, followed by two 12-week treatment phases separated by another 2 weeks of washout. 

Volunteers started either with active treatment and were then switched to placebo, or vice versa.

24 hours after the irradiation phase skin, biopsies were taken from untreated, UVA/B- and UVA1-irradiated skin for subsequent reverse transcriptase polymerase chain reaction analysis of gene expression.

Interestingly, after taking into account of other co and con founders, researchers found that lycopene isolated from tomato exerts a strong activities in completely inhibited UVA1- and UVA/B-induced upregulation of heme-oxygenase 1, intercellular adhesion molecule 1 and matrix metallopeptidase 1, through restrict the transformation of mRNA in initiated cell changes.

Blood samples taken from lycopene treatment group, showed a clinically relative protective effect of skin cells through its inhibition of levels of oxidative stress induced by UVA1- and UVA/B exposure in compared to other groups. 

In compared to lycopene active group, group treated with lutein injection provided complete protection taken in the first period but showed insignificantly effects in the second sequence.

These results suggested that there must be some unknown mechanisms to cause the reduced levels of
lutein in the second sequence in compared to TNC.

Dr. Grether-Beck S, the lead author said, " the role of these genes as indicators of oxidative stress, photodermatoses and photoageing" and " these results might indicate that TNC and lutein could protect against solar radiation-induced health damage".

Furthermore, in re evalueat the effect of Carotenoids in skin photoprotection against UV radiation through analysis of the collection of dermal biopsies of healthy humans (N=27) and blood samples, researchers reconfirmed that lycopene and beta-carotene made up the majority of carotenoids in both skin and plasma followed by beta-cryptoxanthin.

These expressions suggested that lycopene and beta-carotene may play important role in improved skin health through its antioxidant activity in compared to other members of carotenoids such as
dihydroxycarotenoids, lutein and zeaxanthin.

In other words, skin of human is relatively enriched in lycopene and beta-carotene, compared to lutein and zeaxanthin, possibly reflecting a specific function of hydrocarbon carotenoids in human skin photoprotection. 

Additionally, in the examine the skin collected from 74 men and women with diverse skin pigmentation using the Resonance Raman spectroscopy (RRS) to measure of the palm, inner arm, and outer arm were obtained at baseline, 1 wk, 2 wk, 1 mo, 3 mo, and 6 mo (to maximize seasonal variation), researchers with no surprise found that total carotenoids across time are 0.97 (palm), 0.95 (inner arm), and 0.93 (outer arm).

Similarly, assessment of lycopene by RRS was significantly correlated with lycopene assessed by HPLC of dermal biopsies (r = 0.74, P < 0.0001).

These finding once again indicated the protective effect of tomato and bioactive ingredient lycopene in skin health in compared to other compounds.

Taken together, there is no doubt that tomato with its major bioactive phytochemical may be considered as functional food in improved skin health against skin damage caused by numbers of negative implications including oxidative stress, photodermatoses and photoageing

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Molecular evidence that oral supplementation with lycopene or lutein protects human skinagainst ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study by Grether-Beck S1, Marini A1, Jaenicke T1, Stahl W2, Krutmann J1(PubMed)
(2) Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults by Scarmo S1, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST(PubMed)
(3) Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake by Mayne ST1, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W.(PubMed)

How to Increase your Life Expectancy Naturally, Medline Studies Reveal

By Kyle J. Norton

Intake of coffee may have a profound effect in strengthen the telomere length, a biomarker of living longer, some researchers suggested.

The results of the investigation based on the medical guideline and criteria were carried out by some universities, including the National Cancer Institute and Brigham and Women's Hospital and Harvard Medical School.

Coffee, second to tea consumption, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In a cross-sectional association between coffee consumption and telomere length in 4780 women , using the data from the Nurses' Health Study (NHS) from a prospective cohort study of female nurses began in 1976 with relative telomere length measured in peripheral blood leukocytes by the quantitative real-time polymerase chain reaction, after adjusting to other risk factors, researchers found that
1. Higher total coffee use were significantly associated with longer telomeres in compared to non drinkers
2. Intake of 2 to <3 and ≥3 cups of coffee/d showed a relative ratio of 1.29 and 1.36, respectively
3. Telomere length was associated linearly to caffeine consumption from all dietary sources


The findings showed a strong indication of correlation between coffee caffeine intake and the length of telomeres among female nurses.


Dr. Liu JJ, the led author said, " ... better understand the influence of coffee consumption on telomeres, which may uncover new knowledge of how coffee consumption affects health and longevity".

Further more, in the differentiation to re confirm the effects of coffee drinking in increased life expectancy, the Brigham Young University also conducted a study obtained the data to examine the coffee longevity efficacy from 5826 adults from the National Health and Nutrition Examination Survey (NHANES) cross-sectionally,

In a total of 5826 adults, using the quantitative polymerase chain reaction method, telomere length compared to standard reference DNA, after adjusting to other risk factors, including age, gender, race, marital status, education, housing, smoking, BMI, physical activity, alcohol use,.. researchers showed that
1. Caffeine consumption was inversely related to telomere length
2. For each 100 mg of caffeine consumed, telomeres were 35.4 base pairs shorter
3. For each 100 mg of caffeine consumed among coffee drinkers only, telomeres were 36.7 base pairs shorter
4. Among non-coffee drinkers only, 40.0 base pairs shorter

In compared to non drinker{(40.0 base pairs shorter), coffee caffeine( 36.7 base pairs shorter) and caffeine( 35.4 base pairs shorter)} coffee intake expressed a positive effect in reduced genetic telomeres lengths much slower.

In other words, coffee caffeine drinkers have had a longer life expectancy in compared to only coffee or caffeine drinkers and non drinkers

Taking altogether, coffee (regardless caffeinated or not and numbers of cups intake per day) expressed a significant effect in enhanced longevity through modulating the DNA implication of living longer in both genders.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee Consumption Is Positively Associated with Longer Leukocyte Telomere Length in the Nurses' Health Study by Liu JJ1, Crous-Bou M2, Giovannucci E3, De Vivo I4.(PubMed)
(2) Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES) by Tucker LA1.(PubMed)

How to Prevent Fibrosarcoma Naturally, MEDLINE Studies Suggest

Eggplant may have a potential and substantial effect in reduced risk and treatment of Fibrosarcoma  some scientists suggested.

Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.

Fibrosarcoma is medical condition characterized by irregular cell growth in the fibrous connective tissue. The tumor can be classified into low grade, intermediate malignancy and high malignancy, depending to different degrees of differentiation:

In the investigation of eggplant (Solanum melongena var. marunasu) extract activity on human fibrosarcoma HT-1080 cell lines, researchers at the Gifu Pharmaceutical University found that delphinidin, a flavonoid pigment containing in the peel, does not affect tumor cell cells interact and attach to a surface, substrate or another cell to the basement membrane matrix Matrigel (MG) to initiate the tumor cells proliferation or migration, but modulated the expression of matrix metalloproteinase(MMP)-2 and MMP-9 secreted by the tumor cell, thus reducing risk of the matrices in stimulated cancer cell growth and tumor expansion.

Basement Membrane Matrix is a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma.

The function of matrix metalloproteinase(MMP)-2 and MMP-9 are to degrade the extracellular matrix (ECM) which plays essential role in collection of extracellular molecules secreted by support cells to provide structural and biochemical support to the surrounding cells.

In vivo, the basement membrane matrix Matrigel (MG) has been used to measure the angiogenic inhibitors and stimulators, repair damaged tissues, and increase tumor growth in some cancer experiments.


Further differentiation of delphinidin in cancer risk insisted that the chemical constituents also restained cancer cell invasion through reduced expression of inhibited serum- and vascular endothelium growth factor(VEGF) in induction of making new blood vessel to provide nutrients and oxygen for proliferation and cancer progression.

Vascular endothelial growth factor (VEGF) is a potent stimulator of angiogenesis, associated with unfavorable clinical characteristics by promoting proliferation secreted by various human cancers.
Moreover, researchers also indicated that the efficacy of anti cancer cell activity of delphinidin was attributed to the function of phytochemical in triggering extracellular signal–regulated kinases (ERKs) in regulated cancer cell cycle division, including meiosis, mitosis, and post mitosis.


In depth analysis also discovered that delphinidin isolated from eggplant also activated the independent of nitric oxide pathway in suppression of cancer cell progression by initiated cell cycle arrest in the G(0)/G(1) phase.

Interestingly, gallic acid and anthocyanins, the bioactive chemical constituents isolated from eggplant and other fruits and vegetables in the study of human fibrosarcoma HT-1080 suggested that injection of gallic acid and anthocyanins derivative delphinidin-3-glucoside demonstrated a significant activity in induction of cell apoptosis through cytotoxicity.


According to the Zymographic analysis, gallic acid exerted the anti cancer cell growth and tumor invasiveness through inhibited the secretion and activation of gelatinase proteases in breaking down protein into its building blocks, amino acids of MMP to activate cancer progression and metastasis by the tumor.
In human, gelatinases are expressed by matrix metalloproteinases MMP2 and MMP9.
Importantly, gallic acide also ameliorated cancer progression through inhibition of the matrix metalloproteinase(MMP)-2 and MMP-9 same as the effectiveness as delphinidin involved in anti angiogenestic activity.


Taken together, eggplant with abundant bioactive chemical compounds such as gallic acid and anthocyanins may be used as functional food for reduced risk and treatment of fibrosarcoma, depending to further investigation.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcomaHT-1080 invasiveness in vitro by Nagase H1, Sasaki K, Kito H, Haga A, Sato T.(PubMed)
(2) Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2 by Martin S1, Favot L, Matz R, Lugnier C, Andriantsitohaina R.(PubMed)
(3) Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action by Filipiak K1, Hidalgo M, Silvan JM, Fabre B, Carbajo RJ, Pineda-Lucena A, Ramos A, de Pascual-Teresa B, de Pascual-Teresa S.(PubMed)

A Possible Cure of Nonalcoholic Fatty Liver Disease (NAFLD) Naturally? MEDLINE Studies Show

Kyle J. Norton


Anise together with change of diet pattern may have a potential and substantial effect in cure of  nonalcoholic fatty liver disease (NAFLD).

Nonalcoholic fatty liver disease is medical condition characterized by fat accumulated in the liver tissue other than excessive consumption of alcohol.

According to the American liver foundation, Nonalcoholic Fatty Liver Disease is one of most common cause of liver disease and approximately 30% (100 millions) individuals in the United States are estimated to have nonalcoholic fatty liver disease.

The causes of Nonalcoholic Fatty Liver Disease are unknown. Also, as of today researchers do not understand why some people are susceptible to liver fat accumulation while others are not.

However, some researchers suggested that combined health problems such as over weight and obesity, insulin resistance, hyperglycemia and hyperlipidemia may all contribute to the onset of the diseases.

Prolonged and untreated Nonalcoholic Fatty Liver Disease may induce complication of cirrhosis, a disease characterized by late-stage of fibrosis in the liver and untreated cirrhosis can lead to life threatening diseases, such as a coma, liver failure, or death.

Shahid Beheshti University of Medical Science in the examine the results of selected studies including in 33 full text and 7 articles suggested that

*Intakes of red meat, fats, and sweets are associated to elevated risk of NAFLD and consumption of whole grains, fruits and vegetables are associated to reduced risk of NAFLD.

* There is a highly positive association between the Western dietary pattern and the risk of NAFLD.

The university experiment also found that adherence to the Mediterranean diet was significantly associated with the attenuated severity of hepatic steatosis through improving insulin sensitivity in insulin-resistant population with NAFLD,

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, the Islamic Azad University conducted an experiment of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO)

During the course and the end of the experiment researchers showed that both applications exert significantly reverse activities in
* Increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and

* Decreased high-density lipoprotein level caused by choline-deficient diet in dose-dependent manner.

Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as indications of either liver injure or damage caused by the acute inflammation in the experiential subject model.

However, patients with nonalcoholic fatty liver disease may have normal transaminase levels.

Levels of aspartate aminotransferase (AST) is usually used as a maker to detect liver damage.

Serum levels of alanine aminotransferase (ALT) are the best predictor of NAFLD after considering to other clinical and biochemical features.

Observation of injection of anise AE and AO also exerted a powerful antioxidant activity in significantly lower over expression of ROS in exhibited free radical chain reaction in induction of oxidative stress to precipitate liver toxicity.

According to the St. Louis University Health Sciences Center, over expression of free radicals in the liver can damage cellular macromolecules in induction of hepatocellular injury.

Also, in histological findings, both AE and AO displayed a substantial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.

Further analysis of the experiment, researchers found that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).

Elevated 8-Isoprostane values activated by lipid peroxidation induced by injection of choline-deficient diet were also considered as a biomaker in patient with non alcoholic liver disease and correlated to with body mass index and total cholesterol in NAFLD but did not significantly relate to sex, age, biochemical data or iron metabolism markers in all liver diseases.

Therefore, people with high body mass index and high levels of total cholesterol levels are susceptible in increased risk of the diseases.

Taken together, intake of herbal Anise with abundant of bioactive chemical constituents and change of diet pattern with rich of whole grains, fruits and vegetables may have a highly potential in cure of non alcoholic liver disease,

However, further data collection on larger sample and multi centers clinical studies performed with human consumption during the course of the disease will be necessary to complete the picture of its anti nonalcoholic fatty liver disease (NAFLD) possibilities.

Intake of Anise extract should only be prescribed by related field specialist in prevention of acute liver toxicity.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
(2) Relationship between Diet and Non-alcoholic Fatty Liver Disease: A Review Article by Mirmiran P1, Amirhamidi Z1, Ejtahed HS1, Bahadoran Z1, Azizi F2(PubMed)

How to Protect Yourself Against Liver Cancer Naturally and Easily, PubMed Model Studies Suggest

Kyle J. Norton

Green tea may have a potentially hepoprotective effect in inhibited onset and progression of liver cancer, some institutes suggested.

Liver disease is a reduced function of liver, as a result of damage or injure, causing by medication, viral infection,....

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Adding to slice of ginger in your beverage will do the trick of getting rid over yin expression, recommended for long term users.

According to the joint study lead by the Zhujiang Hospital of Southern Medical University Guangzhou, in the review of the data base of PubMed, CNKI, Wanfang and Weipu databases, regular green tea drinking was associated to a significant reduction of risk of liver disease(1), including hepatocellular carcinoma, liver steatosis, hepatitis, liver cirrhosis and chronic liver disease.

Green tea demonstrated a reduced risk of liver disease regardless of the race and geography(1) of the patients resided such as Asian, American and European subgroups.

Liver cancer is a medical condition caused by cell growth disorderly and uncontrollably in the liver tissue.

At the later stage, the cancerous cells may travel a distance away to infect other healthy organs and tissues.

Epidemiological studies suggested that green tea bioactive phytochemicals Epigallocatechin gallate (EGCG) and Theaflavin (TF) displays a strong inhibition of liver cancer through several mechanisms.

In liver cancer animal model induced by chronic exposure of N-nitrosodiethylamine (NDEA), a carcinogenic and mutagenic organic compound, application of green tea bioactive compounds Epigallocatechin gallate (EGCG) and Theaflavin (TF) demonstrated a strong effect in reduced initiation of cancer formation and potential chemopreventive effect in pre and post treatment of the injected animal(5).

N-Nitrosodiethylamine (NDEA) is an inducer of  hepatocarcinogenic dialkylnitrosoamine, presented in tobacco smoke,.........

Further observation of EGCG/TF action in inhibited over expression of liver cancer, researchers found that the compounds also induce cancer cell death, similarly to those of CD44-specific cell membrane binding combined with near-infrared irradiation in induction of cellular apoptosis(5).

High CD44-positive expression is associated to acute cancer cells.

More over, the restriction processes of EGCG/TF in modification of the onset of liver cancer development, was found to regulate multiple biogenesis involved maintaining a relatively stable equilibrium in organs tissues, during the carcinogenesis processes., including
* The self-renewal Wnt/β-catenin and Hh/Gli1 pathways with implication of cell cycle progression, apoptosis and cellular transformation and cell differentiation and

* Cell proliferation involved Cyclin D1, a protein required for progression through the G1 phase of the cell cycle; cMyc found in increased expression of many genes that can induce formation of cancer; and EGFR with strong impact in triggering cancer cell growth and division (proliferation) and cell survival.

* Tumor suppressor (E-cadherin), a type of cell adhesion molecule, with function involved in cancer progression and metastasis.(5)

Interestingly, the therapeutic efficacy of tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) also regulated the proteins expression of cell differentiation, polarity and proliferation(the self-renewal Wnt and Hedgehog (Hh) pathways)(6).during CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.

Where hedgehog (Hh) pathways is important signaling cascades involved tumor growth and metastasis.
Application of green tea bioactive tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) induced chemo preventive potential in maintain cell integrity at the 30 weeks of CCl4/N-nitosodiethylamine application(6).

Continuous administration of EGCG/TF once gain exerted a strong impact in reduced proliferation and increased apoptosis, as well as decreased function of hepatic progenitor cells (HPCs) in participated restoration of the cancerous liver tissue and population with cancer stem cell-like characteristics in liver carcinoma(6) observed by AFP and CD44 expression.in CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis.

Also, during the restriction processes of EGCG/TF, the bioactive compounds also modulated
* The expression of tumor progression to a more invasive phenotype(phospho-β-catenin-Y-654), through enhancing Wnt signalling;

*The proliferation, migration and invasion of liver cancer gene, secreted frizzled-related proteins (SFRPs) due to SFRP1 is lost in cancer cells and over expresion of SFRP2 and 4 derived from the tumor stromain in initiated tumor proliferation, migration and invasion.

* The gene in control tumor suppressor(β-catenin)(6). Mutation β-catenin is associated to various diseases, including cancers.

In short, green tea EGCG/TF inhibited the contaminated cells inflicted by injection of CCl4/N-nitosodiethylamine to prevent the initiation of liver cancer through modulation of certain gene expressions involved in liver cancer initiation and progression.

However, further data collection on studies performed with human consumption during the course of the disease will be necessary to complete the picture of its potential in inhibited liver cancer possibilities.

Intake of supplementation should be taken with especial care in prevention of acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography: Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effect of green tea intake on risk of liver disease: a meta analysis by Yin X1, Yang J2, Li T3, Song L4, Han T5, Yang M1, Liao H1, He J1, Zhong X1.(PubMed)
(2) Green tea extract: a potential cause of acute liver failure by Patel SS1, Beer S, Kearney DL, Phillips G, Carter BA.(PubMed)
(3) Green tea extract: a potential cause of acute liver failure by Patel SS1, Beer S, Kearney DL, Phillips G, Carter BA.(PubMed)
(4) Acute liver failure induced by green tea extracts: case report and review of the literature by Molinari M1, Watt KD, Kruszyna T, Nelson R, Walsh M, Huang WY, Nashan B, Peltekian K.(PubMed)
(5) Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice by Sur S1, Pal D2, Roy R2, Barua A2, Roy A3, Saha P2, Panda CK4.(PubMed)
(6) Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways by Sur S1, Pal D2, Mandal S3, Roy A4, Panda CK5.(PubMed)