Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday 22 March 2018

The Story of Vitamin C in Expression of Breast Cancer

By Kyle J. Norton

Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables. It is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support.

Epidemiological studies linking vitamin C in reduced risk of breast cancer may be inconclusive(1)(1a)(1b), but no doubt in acceptance of improved quality of life(2).

Macro nutrients intake may form an important parts in breast cancer patients in providing vital support for treatment.(3). There was a report of intake of supplementation of multiple vitamin, beta-carotene, vitamin C, vitamin E and zinc in postmenopausal women for 10 or more years may protect women from developing breast cancer(3a).

Women with breast cancer in the Indian population, were found to have a lower levels of mean vitamin C, vitamin E and selenium than controls. if the levels of mean vitamin C, vitamin E and selenium increased by 1 unit, the risk of breast cancer was reduced by 7%(3b).

In breast cancer survival, dietary vitamin C intake before breast cancerdiagnosis may be associated with breast cancer survival. but not in post-diagnosis(4).

High intake of ascorbic acid was in associated to reduce risk of breast cancer incidence in overweight women and women with high consumption of linoleic acid (average consumption of more than 6 grams of linoleic acid per day)(5) and insignificant risk in other breast cancer patients(6).

On inflammation in cancer patients, high dose intravenous ascorbic acid therapy, decreased the levels of C-reactive protein thus reduced inflammation correlated with decreases in tumor marker levels(7).

Vitamin C supplements and Anthocyanin (Ixor®) at a dose of 2 tablets/day, starting from 10 days before the radiation treatment until 10 days after the end of treatment was found to be protective against skin damage to patient undergoing adjuvant chemotherapy(8).

In estrogen-induced breast carcinogenesis, vitamin C (Vit C) and butylated hydroxyanisole (BHA) found to be effective in inhibition of 17β-estradiol (E2)-mediated oxidative stress and oxidative DNA damage by preventing the decreasing NRF2(antioxidant response pathway) and OGG1(base excision repair.) levels(9).

In the study of the same but in MCF-10A cells, the combination also decreased E2-mediated increase in 8-OHdG(Marker detected in cancer patients) levels in the mammary tissues, induced SOD3 (Extracellular superoxide dismutase [Cu-Zn]) through NRF2 Pathway to defense against oxidative stress and in the prevention of estrogen-mediated breast cancer(10).

An increased expression of the miR-93(Regulate Expression of Tumor Suppressor Gene) was found in 17β-estradiol (E2)-treated mammary tissues and in human breast cell lines, treatment with vitamin C reverted E2-mediated increase in miR-93 levels by upregulating expression NRF2 antioxidant response pathway(11).

In 4T1 breast cancer cells in vitamin C-deficient mice, Ascorbic acid delayed the progress of metastasis, tumor growth and inflammatory cytokine secretion (decreased serum inflammatory cytokine interleukin (IL)-6) as well as enhanced encapsulation of tumors(12).

In L-ascorbate (L-ascorbic acid, vitamin C), increasing the concentration exhibited the autophagic damage to functional SVCT-2(antibody) sensitizes breast cancer cells(13).

In B16F10, L-ascorbate also caused induction of a prooxidant state, subsequent reduction in mitochondrial membrane potential to induced apoptosis in a caspase-8(Cell apoptosis)-independent manner(14).

In the usage of glucan, resveratrol and vitamin C, the combination showed the strongest activator of phagocytosis (immune cell activation) and antibody formation to suppress the growth of breast and lung tumors, through stimulation of apoptosis(15).

In 4T1 cancer cell line, combined with ascorbate, Mn(III)N-alkylpyridylporphyrins (MnPs) inhibited cancer cells via peroxide produced outside of the cell through enhancing tumour oxidative stress and tumor growth suppression(16).

In Ataxia telangiectasia mutated (ATM) diplotype on the breast cancer, vitamin C enhanced the increase of ATM to reduce the risk of breast cancer.(17).

In E(2) metabolism and oxidant stress in involved in estrogen-induced breast cancer development, vitamin C reducesd the incidence of estrogen-induced mammary tumors, increased tumor latency and decreases oxidative stress in vivo(18).

In SK-BR3 and Hs578T breast cancer cell lines, Vitamin C treatment induced AIF(apoptosis-inducing factor) mediation of cell death pathway of the breast cancer cell lines independent to caspase pathway(19).

In human breast cancer cell line MCF-7, combination of Retinoic acid and ascorbic acid inhibited the proliferation of human breast cancercells through altering their gene expression related to antioxidation processes and the proliferation inhibitory pathway(20).

Taking all together, without going into reviews, vitamin C is effective in reduced risk and treatment of breast cancer.

Daily ingestion of high-dose vitamin C may be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(21)(22).

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(1) Vitamin C suppresses cell death in MCF-7 human breast cancer cells induced by tamoxifen by Subramani T, Yeap SK, Ho WY, Ho CL, Omar AR, Aziz SA, Rahman NM, Alitheen NB.(PubMed)
(1a) Vitamin supplement consumption and breast cancer risk: a review by Misotti AM, Gnagnarella P.(PubMed)
(1b) Dietary fiber, vitamins A, C, and E, and risk of breast cancer: a cohort study by Rohan TE, Howe GR, Friedenreich CM, Jain M, Miller AB.(PubMed)
(2) Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany by Vollbracht C, Schneider B, Leendert V, Weiss G, Auerbach L, Beuth J.(PubMed)
(3) Nutritional assessment of selected patients with cancer.

Surwillo A, Wawrzyniak A.(PubMed)
(3a) Antioxidants and breast cancer risk- a population-based case-control study in Canada by Pan SY, Zhou J, Gibbons L, Morrison H, Wen SW; Canadian Cancer Registries Epidemiology Research Group [CCRERG].(PubMed)
(3b) Association between breast cancer and vitamin C, vitamin E and selenium levels: results of a case-control study in India by Singh P, Kapil U, Shukla NK, Deo S, Dwivedi SN.(PubMed)
(4) Vitamin C intake and breast cancer mortality in a cohort of Swedish women by Harris HR, Bergkvist L, Wolk A.(PubMed)
(5) Dietary antioxidant vitamins, retinol, and breast cancer incidence in a cohort of Swedish women by Michels KB, Holmberg L, Bergkvist L, Ljung H, Bruce A, Wolk A.(PubMed)
(6) Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. by Verhoeven DT, Assen N, Goldbohm RA, Dorant E, van 't Veer P, Sturmans F, Hermus RJ, van den Brandt PA.(PubMed).
(7) Effect of high-dose intravenous vitamin C on inflammation in cancerpatients by Mikirova N, Casciari J, Rogers A, Taylor P.(PubMed)
(8) Skin toxicity from external beam radiation therapy in breast cancerpatients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®) by Di Franco R, Calvanese M, Murino P, Manzo R, Guida C, Di Gennaro D, Anania C, Ravo V.(PubMed)
(9) Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer by Singh B, Chatterjee A, Ronghe AM, Bhat NK, Bhat HK(PubMed).
(10) Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer by Singh B, Bhat HK.(PubMed)
(11) MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis by Singh B, Ronghe AM, Chatterjee A, Bhat NK, Bhat HK.(PubMed)
(12) Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice by Cha J, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M.(PubMed)
(13) SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment by Hong SW, Lee SH, Moon JH, Hwang JJ, Kim DE, Ko E, Kim HS, Cho IJ, Kang JS, Kim DJ, Kim JE, Shin JS, Jung DJ, Jeong YJ, Cho BJ, Kim TW, Lee JS, Kang JS, Hwang YI, Noh DY, Jin DH, Lee WJ.(PubMed)
(14) L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway by Kang JS, Cho D, Kim YI, Hahm E, Yang Y, Kim D, Hur D, Park H, Bang S, Hwang YI, Lee WJ.(PubMed)
(15) Combination of glucan, resveratrol and vitamin C demonstrates strong anti-tumor potential.

Vetvicka V, Vetvickova J.(PubMed)
(16) Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate by Ye X, Fels D, Tovmasyan A, Aird KM, Dedeugd C, Allensworth JL, Kos I, Park W, Spasojevic I, Devi GR, Dewhirst MW, Leong KW, Batinic-Haberle I.(PubMed)
(17) Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk by Lee SA, Lee KM, Lee SJ, Yoo KY, Park SK, Noh DY, Ahn SH, Kang D.(PubMed)
(18) Vitamin C and alpha-naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female ACI rats by Mense SM, Singh B, Remotti F, Liu X, Bhat HK.(PubMed)
(19) Ascorbate (vitamin C) induces cell death through the apoptosis-inducing factor in human breast cancer cells by Hong SW, Jin DH, Hahm ES, Yim SH, Lim JS, Kim KI, Yang Y, Lee SS, Kang JS, Lee WJ, Lee WK, Lee MS.(PubMed)
(20) Retinoic acid and ascorbic acid act synergistically in inhibiting human breast cancer cell proliferation by Kim KN, Pie JE, Park JH, Park YH, Kim HW, Kim MK.(PubMed)
(21) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
(22) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis by Urivetzky M, Kessaris D, Smith AD.(PubMed)

Warning to: Fish Omega 3 Supplement Consumers, Beware of 14 Side Effects

Kyle J. Norton

Omega-3 fatty acids are phytochemincals in the class of lipids, found abundantly in deep sea fish, dark-green leafy vegetables, grains, legumes, nuts,.....

Fish oil omega-3 fatty acids, contained mainly eicosapentaenoic acid and docosahexaenoic acid, although the supplement has been found to process some significant effects in the management and treatment of several diseases, many of which are inflammatory in nature. However, the supplement may induce some outlined adverse effects.

1. Altered platelet function Omage 3 fatty acid made from fish may have a strong implication on plaletet function due to the presence of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in increased occlusion time and sharply reduced accumulation of fibrin under flow conditions(1)(2).

Therefore, people with normal bleeding problem should be avoid taking the supplement(2).

2. Gastrointestinal adverse effects

Although Omega-3 fatty acids may have a potential in triglycerides lowering, reduction of inflammatory indices, immunomodulation, anti- thrombotic effects, particularly in gastro-protective activity. However, when the healthy supplement taken together with cortisone may cause gastrointestinal bleeding in induction of duodenum ulcer.

This result may be attributed by cortisone in increased oxidation in render them proinflammatory(3).

Other researchers suggested that over doses of omega-3 fatty acids may enhance intestinal production and secretion of intestinal alkaline phosphatase (IAP), in induction of the induces changes of gut bacteria composition resulting in decreased lipopolysaccharide production and gut permeability(7).

3. Detrimental Effects on Wound Healing

In the observation of epidermal growth factor receptor (EGFR)-mediated signaling is required for optimal intestinal wound healing, researchers found that during the early response to intestinal wounding, DHA and EPA uniquely delay the activation of key wound-healing processes in the colon through at least in part suppression of EGFR function(4).

4. Increased risk of lipid peroxidation

Omega 3 fatty acide may interact with reactive oxygen species ROS in inscreased risk of lipid peroxidation in induction of ethane expression in human breath(5).

5. Toxin exposure

Omega 3 fatty acid produced by large amounts of fish may result in adverse effect due to the potential presence of environmental toxins such as mercury, polychlorinated biphenyls, dioxins,.... (8).

Moreover, omega-3 fatty acid preparation may undergo oxidation incontribution to patient intolerance and potential toxicity(8).

6, Weight gain

Intake of omega 3 fatty during pregancy may have a potential effect in induced weight gain of male offspring a poor outcomes associated with high maternal weight gain early in pregnancy(10)..

7. Altered immune function

Omega 3 fatty acide with abubdant arachidonic acid, EPA and DHA contents may alter the balanced pattern of production of eicosanoids and probably also of docosanoids and resolvins, affecting phagocytosis, T-cell signaling and antigen presentation capability.(11).

8. Glycemic control
According to a randomized double-blind crossover study in compared 6 wk of n-3 fatty acid supplementation (12 g fish oil) and corn plus olive oil, long term intake of 3 fatty acid supplementation expressed in increased glycerol gluconeogenesis in contribution to deterioration of glycemic control(12).

However, during the 6 weeks of experiment, researchers also found intake of n-3 fatty acid supplementation lowers triacylglycerols in patients with non-insulin-dependent diabetes mellitus without worsening glycemic control(12).

Drug interactions
Intake of Omega-3 fatty acids
9. May increase the effects of blood thinning medications, including aspirin, warfarin (Coumadin), and clopedigrel due to its anti coagulative activity(13).

10. May increase fasting blood sugar levels, thus reducing the effect of blood sugar lowering medications, such as ,glipizide (Glucotrol and Glucotrol XL), glyburide (Micronase or Diabeta), glucophage (Metformin)(13).

11. Lower the effect of Cholesterol-lowering medications due to the alternation of ratio of good and bad cholesterol(13).

12. Pregnancy and 13. Lactation

Consumption of the nutrients omega-3 fatty acids (omega-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. However, according to the animal study by the Wayne State University School of Medicine, Consuming or administering large or inadequate amounts of omega-3 FA during pregnancy and lactation may induce the potential for adverse effects on infant development(6).

14. Impair host resistance to intracellular pathogens

In the study of Wild-type and fat-1 transgenic mice infected with virulent H37Rv M. tuberculosis via the aerosol route, observartion of bacteriological and histopathological changes in lungs, researchers suggested that endogenous production of n-3 PUFAs in fat-1 mice increases their susceptibility to tuberculosis due to impaired bacterial control in cells and reduced proinflammatory cytokine secretion, impaired oxidative metabolism, and diminished M. tuberculosis-lysotracker colocalization within phagosomes(9).

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Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Potential adverse effects of omega-3 Fatty acids in dogs and cats by Lenox CE1, Bauer JE.(PubMed)

(2) Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation byLarson MK1, Tormoen GW, Weaver LJ, Luepke KJ, Patel IA, Hjelmen CE, Ensz NM, McComas LS, McCarty OJ.(PubMed)

(3) Gastrointestinal bleeding after high intake of omega-3 fatty acids, cortisone and antibiotic therapy: a case study by Detopoulou P1, Papamikos V.(PubMed)

(4) Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing by Turk HF1, Monk JM, Fan YY, Callaway ES, Weeks B, Chapkin RS(PubMed)

(5) Increased levels of ethane, a non-invasive marker of n-3 fatty acid oxidation, in breath of children with attention deficit hyperactivity disorder by Ross BM1, McKenzie I, Glen I, Bennett CP.(PubMed)

(6) Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acidconsumption by the mother by Church MW1, Jen KL, Stafferton T, Hotra JW, Adams BR.(PubMed)

(7) A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia by Kaliannan K1, Wang B1, Li XY1, Kim KJ1, Kang JX1.(PubMed)

(8) Safety considerations with omega-3 fatty acid therapy by Bays HE(PubMed)

(9) Transgenic mice enriched in omega-3 fatty acids are more susceptible to pulmonary tuberculosis: impaired resistance to tuberculosis in fat-1 mice by Bonilla DL1, Fan YY, Chapkin RS, McMurray DN.(PubMed)

(10) Maternal Weight Gain Regulates Omega-3 Fatty Acids in Male, Not Female, Neonates by O'Tierney-Ginn PF1, Gillingham M2, Fowler J3, Brass E4, Marshall NE5,6, Thornburg KL(PubMed)

(11) Immunomodulation by omega-3 fatty acids by Calder PC(PubMed).
(12) Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus by Puhakainen I1, Ahola I, Yki-Järvinen H.(PubMed)
(13) Possible Interactions with: Omega-3 Fatty Acids by Pennstate University

Food Therapy: Intake Fennel to Optimize the Digestive Functioning in absorbed Nutrients and Fluids

Kyle J. Norton

Fennel may have a therapeutic and enhanced effect in improve digestive system in absorbed nutrients and fluids from foods intake, some scientists suggested.

The result of this efficacy was published online by several respectable institutes, including the University of Illinois at Chicago and Afyon Kocatepe University.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.

According to the study, researchers set out a criteria and guideline to investigate the effect of fennel in gram-negative bacterium Helicobacter pylori (HP), the microorganisms has been associated with the development of gastritis and peptic ulcer disease to confirm the theory of used in traditional medicine fennel to treat a wide range of ailments, including gastrointestinal (GI) disorders such as dyspepsia, gastritis and peptic ulcer disease (PUD), application of methanol extracts of botanicals with a MIC of 50 microg/mL included Achillea millefolium, Foeniculum vulgare (seed), exerted a significantly inhibitory effect against all susceptibility of 15 HP strains.

These results suggested that injection of fennel displayed a potential in balanced the ratio of micro organisms in the gastrointestinal tract, thus improve the function in absorbed and distributed nutrients to the body and reassured the herbal medicine used in practice for treatment of numbers symptoms of

digestive disorder.

Furthermore, in animal model with rat induced gastric lesions by injection of ethanol, application of aqueous extracts of Foeniculum vulgare (FVE) showed a strong activity in inhibited the ulcerogenic expression through its antioxidant activities..

In observation of the efficacy of 60 minutes pre administration of the doses of 75, 150 and 300 mg/kg, with famotidine, histamine H₂ receptor antagonist with function to inhibit stomach acid production, used at the dose of 20 mg/kg, before injection of ethanol, researchers found that

* Pre treatment of all dose exerted a significant gastric protective effect in reduced injure and damage caused by injection of ethanol.

* Fennel extract demonstrated a theurateutic activity linearly in compared to other doses and control at dose of 300 mg/kg

* These activities was associated to reduce the malondialdehyde (MDA) levels, a marker in expression of severe levels of oxiadive stress.

Additional analysis, also suggested that fennel stimulated gastro-protect effect through its antioxidants and facilitated production of antioxidants found in the body tissues in inhibited the over expression of free radicals, Thus maintaining the ratio of micro organisms in the digestive tract and its functioning.

After, taking into account of other co and con founders, researchers also suggested that the result in part may also attributed to antioxidant in ameliorated lipid peroxidation.

The above differentiation were supported by the joint report lead by the Joint Keio University in the investigation of fennel properties in associated to functional dyspepsia (FD), a functional gastrointestinal disorder characterized by persistent or recurrent postprandial upper abdominal discomfort and epigastric pain.

Truly, Delayed gastric emptying and impaired gastric accommodation was found to play important roles in the development of FD.

Anethole (1-methoxy-4-((E)-propenyl)-benzene), a major component of fennel essential oil, in in rodents exerted a huge effect in improved clonidine-induced delayed gastric emptying without harming to normal gastric emptying in mice, orally.

Also, application of fennel oil plus Anchu-san (a Japanese herbal medicine containing anethole) also demonstrated a important activity in reduced risk of functional dyspepsia (FD) through restoring the delayed gastric emptying.

In other words, anethole processes a gastro protective efficacy through stimulating gastric accommodation.

Taken together, whole fennel, fennel essential oil and its bioactive compound anethole may be used as secondary application in reduced risk and treatment of digestive disorder. Adding a portion of fennel in your diet may improve the digestive function in absorption nutrients and fluids from the food intake.

However, intake of supplement should be taken with extreme care as overdose may cause acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders by Mahady GB1, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR.(PubMed)
(2) Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats by Birdane FM1, Cemek M, Birdane YO, Gülçin I, Büyükokuroğlu ME.(PubMed)
(3) Anethole restores delayed gastric emptying and impaired gastric accommodation in rodents by Asano T1, Aida S2, Suemasu S2, Mizushima T3.(PubMed)

6 Herbal Remedies to Detox and Nourish Your Kidneys

American diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances is toxic. Our body’s detoxifying functions try to get rid of them everyday.

When they fail it causes a disruption of hormone production, damaging our body’s detoxification organs and weakens our immune system resulting in hormone imbalance and many chronic illness consequently.

The below are outlined of 6 herbs with therapeutic effects to detox and nourish your kidneys

1. Dandelion leaf
Dandelion is a rich source of vitamins A, B complex, C, and D, as well as minerals such as iron, potassium, and zinc.

Dandelion root has been used for centuries in traditional Chinese medicine in treating liver disease by stimulating the removal of liver toxins. Dandelion leaf on the other hand are used as a diuretic to stimulate the excretion of urine in removing the toxin accumulated in the kidney.

2. Echinacea
Commonly called purple coneflower.

The herb contains a wide variety of chemicals that not only helps to strengthen the immune system but also stimulates the removal of toxins that causes kidney inflammation and infection.

3. Corn silk
Corn silks are the silky fibers that are found under the leaves and on top of an ear of corn. It contains flavonoids, essential oil and minerals that helps effectively in treating acute and chronic inflammation of the urinary system caused by toxins accumulated in the kidney.

4. Artichoke
Artichoke is a perennial thistle originating from southern Europe containing thiamin, riboflavin, niacin.

Antioxidants found in Artichoke not only strengthen our immune system, they also treat kidney diseases by reducing protein expression in the urine caused by toxins through poor diet for a prolonged period of time.

5. Golden rod
Golden rod is a yellow flowering plant in the family of Asteraceae.

Golden rod has been used in traditional medicines as a kidney tonic, and treating urinary infections and stones. Golden rod juice also helps to cleanse of kidney and bladder caused by toxins and inflammation.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Wednesday 21 March 2018

How to Improve Your Brain Functioning Effectively

By Kyle J. Norton

Scientists may have found a food whole plant in exerting neuroprotective effect, the renowned institute study suggested.

According to the MVP Samaj’s College of Pharmacy, methinic extract of beet fed to experiment animal showed a significant effect in increased motor function at 200, and 300 mg/kg, in doses depending manner.

Neuroprotection is an action used to ensure the brain normal function against nerve cells damage, degeneration in inducing impairment.

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the MVP Samaj’s College of Pharmacy, methinic extract of beet fed to experiment animal showed a significant effect in increased motor function at 200, and 300 mg/kg, in doses depending manner.

Oral administrated animal also showed a strong improvement of intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, locomotor activity and grip strength.

The efficacy of the extracted in contribution of brain health may be a result of present phytochemicals in restoring the defensive antioxidant enzymes in the brain against level of lipid peroxidation (LPO), a leading cause of neuro degeneration.

More interestingly, Betalains, major phytochemicals isolated from beetroot also expressed a extraordinary neuro protective effect in preventing oxidative processes in contribution to the early onset of several degenerative diseases.

In the study of betanin bioavailability in four volunteers with consumption 300 mL of red beet juice, containing 120 mg of the antioxidant, reseraches found that the phytochemical showed a protection against certain oxidative stress-related disorders in humans after absorbed from the gut and identified in urine after 2-4 h, particularly in inhibited lipid peroxidation, a leading cause of neuro degenerative disease.

Dr. Kanner J, the lead author said, “Antioxidant nutrients from fruits and vegetables are believed to be a class of compounds that exert their effects in humans by preventing oxidative processes which contribute to the onset of several degenerative diseases”.

Collectively, Whole food beetroot or beet juice may be used as therapeutic agent for preventing the early onset and treatment of neuro degenerative disease through protection of neuro cells against oxidation.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Neuroprotective potential of Beta vulgaris L. in Parkinson’s disease by Nade VS1, Kawale LA1, Zambre SS1, Kapure AB1.(PubMed)
(2) Betalains–a new class of dietary cationized antioxidants by Kanner J1, Harel S, Granit R.(PubMed)

Diabetics Attention: How to Reduce Your Blood Glucose Levels, Medical Literature Suggested

Kyle J. Norton

For my years of practice and research, I do believe that intake of 1/4 table spoon of Vietnmese cinnamon powder in the morning and evening have significant effects to keep blood sugar in check.

Prediabetes with reading of 6.9 mmol/L of a lady I know 10 years ago, after taking the suggested amount daily, reading of the morning blood plucose is maintained at 5.3 mmol/L since.

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professions because of its anti diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects.

According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse side effects.

The herb has been use in herbal and traditional medicine as anti-fungal and bacteria level to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a reduction significant of blood triglyceride levels even in the low-dose group, after 3 months of oral administration(2)

Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering the insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed that “the effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism”(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomon cassia) indicated a improvement of glucose, insulin, cholesterol and HbA1c in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

A randomized clinical trial in which 70 Patients with type II diabetesassigned randomly two groups (35 in cinnamon and 35 in placebo group for the testing of the effect of cinnamon on the glucose level in blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

Taken altogether, cinnamon in low dose may be effective in controlling the levels of blood glucose in patient with diabetes without altering the insulin level. according to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis, and burning sensation in mouth with large amount. The traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damaged to liver(1).

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References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)

Grape Seed Extract Users: Discover 15 Incredible Medical Benefits, According to Phytochemical Resveratrol Medical Literature

Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey.

Grape Seed Extract is the commercial extracts from whole grape seeds, containing many concentrations, including vitamin E, flavonoids, linoleic acid, oligomeric proanthocyanidins(OPCs),...

The herb has been used in traditional medicine as antioxidant, anti-inflammatory agents and to treat skin wounds with less scarring, allergies, macular degeneration, arthritis, enhance circulation of blood vessels, lower cholesterol, etc.

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape wine, nuts, peanuts,....

1. Anti cancers
In the review of resveratrol and it effects as a chemopreventive agent, tumor initation, promotion, and progression via multiple pathways, indicated that resveratrol exerts antioxidant activities, hence contributing to the prevention of tumor initiation. Growing or metastasizing carcinomas are inhibited by resveratrol through prevention of angiogenesis by inhibiting VEGF and matrix metalloproteases. Induction of apoptosis and cell cycle arrest, important mechanisms for cancer therapy, are stimulated by resveratrol through different mechanisms, e.g., activation of p53 and modulation of cell cycle proteins, according to "Fighting cancer with red wine? Molecular mechanisms of resveratrol" by Kraft TE, Parisotto D, Schempp C, Efferth T.(1)

2. Anti cancers and anti inflammatory effects
In the observation of Resveratrol's effects in exhibition of several physiological activities including anticancer and anti-inflammatory activities in vitro and in experimental animal models, as well as in humans, found that Anticancer activity of this compound is mainly due to induction of apoptosis via several pathways, as well as alteration of gene expressions, all leading to a decrease in tumor initiation, promotion, and progression. Resveratrol exhibits anti-inflammatory activity through modulation of enzymes and pathways that produce mediators of inflammation and also induction of programmed cell death in activated immune cells. Resveratrolhas been shown to produce no adverse effects, even when consumed at high concentrations, according to "Potential of resveratrol in anticancer and anti-inflammatory therapy" by Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ.(2)

3. Prostate cancer
In the evaluation of the tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) and the androgen receptor (AR) in tumor development and progression in prostate carcinogenesis, found that resveratrol may act as potential adjunctive treatment for late-stage hormone refractory prostate cancer. More importantly, for the first time, our study demonstrates the mechanism by which AR regulates PTEN expression at the transcription level, indicating the direct link between a nuclear receptor and the PI3K/AKT pathway, according to "Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines' by Wang Y, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C.(3)

4. Cardiovascular diseases
In the revie of reviews some of the key studies, and the known mechanisms for these beneficial effects. Evidence from different experimental studies, including from the authors' laboratories, and the beneficial effects of polyphenols found in red wine, especially resveratrol in grape skins.
found that Resveratrol benefits include a reduction in cardiovascularmorbidity and mortality, lung cancer and prostate cancer by approximately 30% to 50%, 57% and 50%, respectively. Polyphenols possess antioxidant, superoxide-scavenging, ischemic-preconditioning and angiogenic properties. Some of these properties of polyphenols may explain their protective effects on the cardiovascular system, as well as other body organs, according to "Significance of wine and resveratrol in cardiovascular disease: French paradox revisited" by Vidavalur R, Otani H, Singal PK, Maulik N.(4)

5. Cardiovascular health
In the review of Resveratrol (3,4',5-trihydroxystilbene), a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems, indicated that Recently, resveratrol was found to induce autophagy and regenerate myocardial ischemic tissue treated with stem cells. Overall observation indicates that resveratrol has a high therapeutic potentials for the treatment of cardiovascular diseases, according to "Resveratrol and cardiovascular health" by Das M, Das DK.(5)

6. Anti inflammatory effects
In the study of implantation and growth of metastatic cancer cells at distant organs is promoted by inflammation-dependent mechanism, found that resveratrol remarkably inhibited hepatic retention and metastatic growth of melanoma cells by 50% and 75%, respectively. The mechanism involved IL-18 blockade at three levels: First, resveratrol prevented IL-18 augmentation in the blood of melanoma cell-infiltrated livers. Second, resveratrol inhibited IL-18-dependent expression of VCAM-1 by tumor-activated hepatic sinusoidal endothelium, preventing melanoma cell adhesion to the microvasculature. Third, resveratrol inhibited adhesion- and proliferation-stimulating effects of IL-18 on metastatic melanoma cells through hydrogen peroxide-dependent nuclear factor-kappaB translocation blockade on these cells, according to "Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18" by Salado C, Olaso E, Gallot N, Valcarcel M, Egilegor E, Mendoza L, Vidal-Vanaclocha F.(6)

7. Oxidative stress and endothelial dysfunction
In the investiagtion of the role of S6K1 in aging-associated endothelial dysfunction and effects of the polyphenol resveratrol on S6K1 in aging endothelial cells, wrote that our data demonstrate a causal role of the hyperactive S6K1 in eNOS uncoupling leading to endothelial dysfunction and vascular aging. Resveratrol improves endothelial function in aging, at least in part, through inhibition of S6K1. Targeting S6K1 may thus represent a novel therapeutic approach for aging-associated vascular disease, according to "Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol" by Rajapakse AG, Yepuri G, Carvas JM, Stein S, Matter CM, Scerri I, Ruffieux J, Montani JP, Ming XF, Yang Z.(7)

8. Insulin resistance
In the evaluation of the effects of Res on insulin sensitivity and the underlying mechanism, insulin-resistant KKA(y) mice were treated with 2 and 4 g/kg diets of Res for 12 weeks, found that Res intervention reduces blood glucose and serum insulin levels, improves insulin and glucose tolerance, increases serum adiponectin and adiponectin mRNA levels in epididymal adipose tissues, and more importantly, elevates Sirt1, p-AMPK, p-IRS1, and p-AKT levels in liver and soleus muscles, according to "Effects of resveratrol on the amelioration of insulin resistance in KKA(y) mice" by Chen S, Li J, Zhang Z, Li W, Sun Y, Zhang Q, Feng X, Zhu W.(8)

9. Propionibacterium acnes
In the investigation of whether P. acnes biofilms could be eradicated by plant extracts or their active compounds, and whether other mechanisms besides killing of biofilm cells could be involved, found that out of 119 plant in the study, researchers identified five with potent antibiofilm activity against P. acnes (extracts from Epimedium brevicornum, Malus pumila, Polygonum cuspidatum, Rhodiola crenulata and Dolichos lablab). We subsequently identified icariin, resveratrol and salidroside as active compounds in three of these extracts. Extracts from E. brevicornum and P. cuspidatum, as well as their active compounds (icariin and resveratrol, respectively) showed marked antibiofilm activity when used in subinhibitory concentrations, indicating that killing of microbial cells is not their only mode of action, accoridng to "Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds" by Coenye T, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B, Nelis HJ.(9)

10. Healthy heart and longevity
In the review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action,
found that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice, according to "Resveratrol and red wine, healthy heart and longevity" by Das DK, Mukherjee S, Ray D.(10)

11. Antioxidants
In the assessment of the effects of the antioxidants resveratrol and quercetin on frozen-thawed ram sperm, found that Semen samples (which exceeded minimum standards) from four mature crossbreed Santa Inês rams were pooled and aliquots of each pool were diluted in Tris-egg yolk-glycerol, with the addition of 0, 5, 10, 15, and 20 μg/mL of resveratrol and quercetin in Experiment 1 and Experiment 2, respectively. In Experiment 1, the proportion of sperm with a high mitochondrial membrane potential was greater (P < 0.02) in the control group than in resveratrol 20 μg/mL group. In Experiment 2, the proportion of sperm with high mitochondrial membrane potential was greater in the control group (P < 0.0001) than in the other experimental groups, and greater in the quercetin 5 μg/mL group (P < 0.05) than in the other quercetin-treated groups, according to "Effect of antioxidants resveratrol and quercetin on in vitro evaluation of frozen ram sperm" by Silva EC, Cajueiro JF, Silva SV, Soares PC, Guerra MM.(11)

12. Incision-induced acute and chronic pain
In the searching for more efficacious treatments in inhibition of incision-induced pain and prevention of the transition to chronic pain following surgery, found that local injection of resveratrol around the surgical wound strongly attenuates incision-induced allodynia. Intraplantar IL-6 injection and plantar incision induces persistent nociceptive sensitization to PGE2 injection into the affected paw after the resolution of allodynia to the initial stimulus. We further show that resveratrol treatment at the time of IL-6 injection or plantar incision completely blocks the development of persistent nociceptive sensitization consistent with the blockade of a transition to a chronic pain state by resveratrol treatment, according to "Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" by Tillu DV, Melemedjian OK, Asiedu MN, Qu N, De Felice M, Dussor G, Price TJ.(12)

13. Anti diabetes
In the evaluation of resveratrol, a polyphenolic SIRT1 activator and its SIRT1 activation in an in vitro fluorescent based assay (EC(50) : 7 μM) and the efficacy of resveratrol was also evaluated in ob/ob mice for its antidiabetic and associated metabolic effects, found that a significant improvement observed in the glucose excursion in the oral glucose tolerance test performed for 120 min; although an insignificant improvement in the triglycerides, total cholesterol, adiponectin and free fatty acid levels was observed at different doses of resveratrol tested. The present findings suggest that resveratrol is an antihyperglycemic agent and drugs similar to resveratrol can be considered as an effective therapeutic adjuvant for the current treatment of diabetes mellitus, according to "Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes" by Sharma S, Misra CS, Arumugam S, Roy S, Shah V, Davis JA, Shirumalla RK, Ray A.(13)

14. Neuroprotective effects
In the elucidation of the neuroprotective effect and influence of resveratrolon the extracellular levels of neurotransmitter and neuromodulator during ischemia/reperfusion in rats,
found that chronic treatment with resveratrol remarkably reduced the release of excitatory neurotransmitter glutamate, aspartate and neuromodulator d-Serine during ischemia and reperfusion; and significantly increased the basal extracellular levels of inhibitory neurotransmitter gamma-amino-n-butyric acid, glycine and taurine. Chronic treatment with resveratrol also ameliorated O-phosphoethanolamine levels and excitotoxic index during ischemia and reperfusio, according to "Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats" by Li C, Yan Z, Yang J, Chen H, Li H, Jiang Y, Zhang Z(14)

15. Neuroprotective effects
In the investigation of the neuroprotective properties of resveratrol found that Resveratrol has neuroprotective features both in vitro and in vivo in models of Alzheimer's disease (AD), but it has proved to be beneficial also in ischemic stroke, Parkinson's disease, Huntington's disease, and epilepsy, according to "Neuroprotective properties of resveratrol in different neurodegenerative disorders" by Albani D, Polito L, Signorini A, Forloni G.(15).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

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Author biography: Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.