Herbal Therapy: Green Tea in Ameliorated Symptoms, Progression and Treatment of Tendinitis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced symptoms, progression and treatment of tendinitis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Tendinitis is a condition characterized by inflammation of a tendon as a result of overuse, infection or rheumatic disease.

According to the study of the effect of GT and/or glycine in the diet on tendinitis on Wistar rats, randomly divided into seven groups (G): control group (C); G1 and G4, tendinitis; G2 and G5, tendinitis supplied with GT; and G3 and G6, tendinitis supplied with GT and a glycine diet for 7 or 21 days, respectively, group with  tendinitis treated with green tea demonstrated a significant effect in enhanced collagen stablility through expression of hydroxyproline in compared to other groups.

Furthermore, GT and glycine alone treated groups showed an increased activity of metalloproteinase-2 MMP-2 levels which has been associated to the healing process of the fibrous connective tissue in tendinitis patients.

In compared to control and non GT treatment groups, application of green tea or GT+ gyycine group displayed a statistical significance in the decreased muscle retardation.

After taking into account of other co founders, Dr. Vieira CP, the lead author said, " GT + a glycine diet has beneficial effects that aid in the recovery process of the tendon after tendinitis".

Interestingly, in the study investigated the remodeling effects of green tea and glycine in the myotendinous junction (MTJ) of male Wistar rats with tendinitis, randomly divided into five groups: animals without tendinitis and animals with tendinitis; animals with tendinitis supplied with green tea; animals with tendinitis supplied with a glycine diet; animals with tendinitis supplied with a green tea and glycine diet, researcher found that all treatment groups exerted a profound effect in regulated the activity of metalloproteinases (MMP)-2 with function in remodeling the tendon after tendinitis, MMP-8 and -9 which are associated to remodeling tissue expression in the disease progression  and induced the synthesis of type I collagen regulation by cell spreading, platelet-derived growth factor and interactions with collagen fibers.

Moreover, rats groups treated above application also demonstrated an increase of glycosaminoglycans, in stimulated the regenerative processes, while maintaining host cell characteristics and function and non-collagenous proteins in modulated the development of fine fibrils presented in collagen fibers of connective tissue

Additionally, the combination of green tea and glycine also modulated the inflammatory process through stimulated production of anti inflammatory factors and induced the synthesis of the elements, such as extra cellular matrix involved in the post-lesion recovery of the tissue.

These results indicated an important recovery from injured tendon through improving the compaction of the collagen molecules and inducing assembly of early collagen fibers, in green tea and glycin treated groups.

After considering of all cofounders, researchers and colleagues at the Anat Rec said, " each region of the inflamed tendon can exhibit different responses during the treatment and therefore, modify its extracellular matrix components to facilitate recovery and repair".

The information findings suggested that green tea may be considered as a function food for reduced symptoms, progression and used with glycin and conentional standard medicine for treatment of
tendinitis. However, intake of supplement for treatment of  tendinitis should be taken with exceptional care in prevented toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green Tea and Glycine Modulate the Activity of Metalloproteinases and Collagen in the Tendinitis of the Myotendinous Junction of the Achilles Tendon by Vieira CP1, De Oliveira LP2, Da Ré Guerra F3, Marcondes MC2, Pimentel ER2.(PubMed)
(2) Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats by Vieira CP1, Guerra Fda R, de Oliveira LP, Almeida MS, Marcondes MC, Pimentell ER.(PubMed)

Herbal Therapy: Green Tea in Alleviated Symptoms and Treatment of Chronic Back Pain

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Back pain is a condition of Musculo-Skeletal disorders(MSDs) of the spine caused by various factors, including bone fractures, muscle or ligament injure, arthritis, herniated discs. aging,....

Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitate anti inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in induction of back pain.

According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributed to the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.
Further more, application also displayed a strong effect in reduced expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.

Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.

Moreover, in the radiculopathic pain component, researchers also indicated that EGCG inhibited the inflammation in precipitated back pain through modulation of the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in responded to stress stimuli in mediated production of pain related pro inflammatory cytokines such as IL-1β.

Some researchers postulated that back pain may also induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in induced tissue apoptosis.

In crushing of the sciatic nerve induced back pain in tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gain in the percentage motor deficit.

More importantly, EGCG expressed a significant effect in recovery of sensory innervation in neuropathic pain-like syndrome and improvement of muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.

According to the RT-PCR assay, EGCG treatment also normalizing the Bax/Bcl-2 ratio, abnormal ratio of the Bax/Bcl-2 ratio has been found to associate in induction of nerve cell apoptosis as well as inhibited levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.

These results demonstrated a important effect of green tea EGCG in enhanced functional recovery, protected muscle fibers from cellular death, and improved morphological recovery in skeletal muscle after nerve injuries.

However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that in compared to caffeine intake regardless concentration, cffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in a context of other unhealthy life-style behaviors.

Taken together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered as functional food in reduced back pain caused by physical damage of the spine and injured nerve cells. Intake of green tea supplement should be taken exceptional care as some cases of liver acute toxicity have been reported in medical literature.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST.(PubMed)

Herbal Therapy: Green Tea and its Bioactive Egallocatechin-3-gallate (EGCG) in Reduced Risk, Progression and Treatment of Lupus

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and treatment of systemic lupus erythematosus (SLE), some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the body's immune system abnormal function in attacking healthy tissue in many parts of the body.

In the study of patient with lupus nephritis induced by SLE, researchers found that intake of green tea epigallocatechin-3-gallate (EGCG), the major bioactive polyphenol displayed a strong antioxidant effect in reduced expression of reactive oxygen species in activated the activity of proinflammatory factors nuclear factor-kappa B (NF-κB), a protein complex mediated inflammatory responses under stress stimuli in induction of inflammation.

Further analysis, also indicated that application of green tea EGCG decreased levels of interleukin (IL)-1β and IL-18, the inflammatory cytokines which were found to have a closed link to inflammation and correlated with systemic lupus erythematosus (SLE).

Moreover, in the evaluation of 12-week-old New Zealand black/white (NZB/W) F1 lupus-prone mice treated daily with EGCG by gavage until sacrificed at 34 weeks old, researchers at the National Defense Medical Center found that green tea ingestion exerts a strong effect in prevented proteinuria, renal function impairment, and severe renal lesions through increased repression of antioxidant mediated by renal nuclear factor E2-related factor 2 (Nrf2) and enhanced natural antioxidant of glutathione peroxidase produced by the host body.

The over expression of antioxidant activity participated by green tea EGCG also ameliorated the free radical in expression of renal oxidative stress, through reduced NF-κB activation in production of inflammatory cytokine and increased anti inflammatory NLRP3 mRNA/protein expression and mature caspase-1, IL-1β, and IL-18 in response to inflammation caused by immune abnormal activity in systemic lupus erythematosus (SLE).

The result of the study also found that green tea EGCG also enhanced splenic regulatory T (Treg) cell activity in maintain immunologic homeo-stasis and inhibited autoimmunity.

Additional study of green tea, egallocatechin-3-gallate (EGCG) effect in lupus, researchers suggested that green tea exerted a profound anti-inflammatory activity on immune cells through inhibiting the immune-stimulated phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway in attenuated inflammatory response.

In fact the expression of green tea EGCG also reduced the production of nitric oxide (NO) and other inflammatory mediators including iNOS expression, supernatant NO and interleukin-6 in initiation of mesangial cells inflammation in the kidney under abnormal immunity in patients of systemic lupus erythematosus (SLE).

Dr. Peairs A, after taking into account of other co founders said, " EGCG attenuated inflammation in MRL/lpr mouse mesangial cells via the PI3K/Akt/mTOR pathway" and "EGCG to regulate inflammation and control autoimmune disease".

The result of above differentiation were supported by the study conduced by the Medical College of Georgia in the evaluation of the green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), affects autoantigen expression in human cells.

Dr. Hsu S, at the end of the experiment, postulated that green tea bioactive polyphenols EGCG inhibited the transcription and translation of major autoantigens, including SS-B/La, SS-A/Ro, coilin, DNA topoisomerase I, and alpha-fodrin through its anti inflammatory and anti apoptotic tissue effects.

Taken togther, green tea and its bioactive component egallocatechin-3-gallate (EGCG) may be considered  as a functional food in reduced risk and progression and combined with conventional therapy for treatment of systemic lupus erythematosus (SLE). However, intake of green tea supplement should be taken with care in prevented liver acute toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation by Tsai PY1, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A.(PubMed)
(2) Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells by Peairs A1, Dai R, Gan L, Shimp S, Rylander MN, Li L, Reilly CM.(PubMed)
(3) Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the major constituent of green tea) in normal human cells by Hsu S1, Dickinson DP, Qin H, Lapp C, Lapp D, Borke J, Walsh DS, Bollag WB, Stöppler H, Yamamoto T, Osaki T, Schuster G.(PubMed)

Herbal Therapy: Green Tea and its Bioactive Polyphenols in Attenuated Early Onset, Progression and Treatment of Osteoporosis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset. progression and treatment of osteoporosis, some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Osteoporosis is a chronic condition characterized by progression in reduced bone mass and deterioration of bone tissue and considered as a major health problem in both elderly men and women.

In the study to evluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that application of green tea and its bioactive compounds exert significant activities in reduced onset of osteoporosis, through its antioxidants and its initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibited the levels of ROS in facilitated the chain reaction.

Truly, the over expression of free radicals has been associated to the change in balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroyed the calcified tissue and induced bone remodeling.

These results demonstrated a significant decrease of risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.

Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that ingestion of green and its bioactive compound display an impressive osteo-protective impact on bone mass and microarchitecture in various bone loss models associated to aging, sex hormone deficiency, and chronic inflammation.

The implication of reduced onset and progression of osteoporosis in aging population due to sex hormone deficiency of the study may be attributed to green tea and its bioactive compound in increased the levels of osteocalcin, a bone formation marker, decreased serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improved the body in absorption of calcium.

In fact, the serum of serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) are considered as an effective measurement in the rate of bone turn over in patients with osteoporosis.

Interestingly, application of green tea and its bioactive compound also found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibited the production of C-reactive protein (CRP) production in the liver in demonstrated of inflammation by reduced levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.

These differentiation were supported by the study in evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.

At the end of experiment, researchers found that rats treated with GTP demonstrate an increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; increased trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft; decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.

These results indicated a strong implication of green tea polyphenols in decreased cortical and trabecular bone loss and increased both bone density by stimulated over expression of bone formation and reduced bone resorption via antioxidant capacity.
 

Taken together, green tea and its bioactive polyphenols may be considered as a function food in ameliorated early onset, progression and combined with standard medicine for treatment of osteoporosis. However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity. 

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS.(PubMed)

(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS.(PubMed)

(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK.(PubMed)

The Top 8 Essential Foods for Reducing Prostate Cancer Risk

Kyle J. Norton
(The revision of old article)
The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with tendency to effect even younger age population. Evidences emerged of over consuming bad fats in any time in history accompanied with unhealthy diet and life style may be the possible causes of the disease, linking to the economic prosperity over 2 decades.

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. At the later state, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

The top 8 foods for reducing prostate cancer risk
1. Flaxseed
Flax seed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed. Flax is an erect annual plant, it can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.
Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer cell proliferation via vascular endothelial growth factor(VEGF)-associated pathways(76) and diet supplemented with 5% flaxseed inhibited the growth and development of prostate cancer in the TRAMP model(77) and lowered prostate cancer proliferation rates associated with biological alterations(78).

2. Vegetable oil
Vegetables oil is a triglyceride extracted from egetables.
Increased levels of MUFA-rich vegetable oil((including olive oil, canola or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79). Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model and 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).

3. Honey
The rich golden liquid is the miraculous product made by bees using nectar from flowers. the liquids are considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manner(81)

4. Chickpea
Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, with  high sources of protein and mineral, native to Middle East.
7 protease inhibitor concentrates (PICs) isolated from chickpea showed a significant inhibition the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).

5. Olive oil
Extra virgin olive oil (EVOO), was found to significantly affect the growth of HCT 116 tumours xenografted in athymic mice(83) and polyphenols, found in extra virgin olive oil (EVOO) exerted chemopreventive effects towards different organ specific cancers, affecting the overall process of carcinogenesis by inhibition of DNA synthesis, modulation of ROS production, regulation of cell cycle arrest, modulation of survival/proliferation pathways(84).

Moreover, polyphenols application can directly interact with specific steps and/or proteins regulating the apoptotic process in different ways depending on their concentration, the cell system, the type or stage of the pathological process(85).

6. Black pepper
Black pepper, is a flowering vine in the family Piperaceae, used as a spice and seasoning
Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1 and DU-145 prostate cancer cells in a dose dependent manner and induced apoptosis resulted in caspase activation in LNCaP and PC-3 cells(86) and β-caryophyllene oxide (CPO), a sesquiterpene isolated from essential oil of black pepper(Piper nigrum L.) not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and nutrient–hormonal signaling network) pathway signaling cascade but also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21(87).

7. Green tea
Green tea containing more amount of antioxidants than any drinks or foods with the same volume, is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Green tea catechins (GTCs), a potent chemical constituent containing (-)-epigallocathechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment of preprostate cancer men reduced lower urinary tract symptoms, improved coexistent benign prostatehyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).

In green tea polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti cancer effect on signaling pathways in PCa(89).

 Also combination of quercetin and green tea, showed a significant increase in the inhibition of proliferation, androgen receptor and phosphatidylinositol 3-kinase/Akt signaling(tumor genesis in early stage), and stimulation of apoptosis(90).

In short, Green tea, a potent anti prostate cancer with activities of heritable alterations of gene expression and chromatin organization without changes in DNA sequence induced multistep processes of carcinogenesis(91) may be considered as a natural treatment in vary types of cancer.

8. Fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of sometimes.
In the Japan, incidence of prostate caner in aging men are low compared with the Western world, suggestion of these result may be tradition Japanese diet related.
In fact, Traditional Japanese diet rich in soybean products and fish against prostate cancer(92).

 In China, suggestions of reduced risk of prostate cancer are associated with consumption of soy foods and isoflavones found abundantly in fermented soybean products(93). Unfortunately, the epidemiological data, linking ferment soybean products to reduced risk of prostate cancer are inconsistent including miso.

The prevalence and widespread of prostate cancer may be diet, demographic and life style related disease(94)(95)(96). Suggestions and intentions are for prevention of prostate cancer to develop in the first place or used conjunction with conventional medicine in treating the disease.

 Eating healthy, with plenty of vegetables and fruits has always been considered as a preventive engagement in human history. "Let foods be your medicine and let medicine be your foods" by Greek physician Hippocrates (460-377 BC).


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery by Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT.(PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM.(PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH.(PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS.(PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green teapolyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM.(PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW.(PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL.(PubMed)
(95) A prospective study of demographics, diet, and prostate canceramong men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)

Herbal Therapy: Green Tea and Its Bioactive Polyphenols EGCG in Reduced Risk and Treatment of Hepatitis C

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and treatment of hepatitis C, some scientists suggested.

Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Hepatitis C is medical condition induced by contaminated food intake containing hepatitis C virus (HCV).  Hepatitis C has been found to associate with sever liver damage.

According to statistic, approximately 130–150 million people around the world are living with chronic HCV.

Green tea bioactive polyphenols Epigallocatechin-3-gallate (EGCG) in reduced risk and treatment of hepatitis was found to associate numbers of implications through various aspects.

In Huh7.5.1 cells, a HCV cell culture (HCVcc) system using a JFH1-GFP chimeric virus, application of green tea EGCG with 50 % effective concentration (EC(50)) of 17.9 μM demonstrated a strong effect in interrupted HCV progression through monitoring HCV RNA and protein levels in Huh7.5.1 cells infected with the JFH1 virus by preventing the mRNA in transferring infectious cell transcription in facilitated cell proliferation and division.

Importantly, injection of green tea at dose of 50 and 25 μM EGCG, expressed a significant inhibition of the presence of HCV after 2 and 5 passages in HCV cell culture (HCVcc) experiment, using an American Type Culture Collection (ATCC) reference strain, with little affect to the viral internal ribosome entry site (IRES) in initiated substitution of RNA sequences for viral protein synthesis in shutting off classic host translation to evade host immune response.

Notably, in comparison of effect of green tea with potent anti-HCV activity
medicine, cyclosporin A and tamoxifen, researchers indicated that application of green tea showed a strong anti HCV viral activity, similarly to those of anti hepatitis medicine through its antioxidant expression of flavonoids epigallocatechin gallate (EGCG) and 7,8-benzoflavone (α-naphthoflavone), observed in HCV cell culture (HCVcc) by blocking the entry point of the virus in initiated infection to host cells and stimulating the viral cell cycle arrest at the late stage of HCV life cycle, respectively

Interestingly, some researchers in the evaluation of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) in hepatitis C infection suggested that EGCG processed anti viral expression through interrupting the cross link between HCV life cycle involving steps of entry, replication.

Injection of a concentration of 50 μM of EGCG was found to inhibit HCV infectivity by more than 90% at an early step of the viral life cycle.

In deed, the interrupted property in blocking the HCV entry cycle to induce infection to the host cell was confirmed with HCV pseudoparticles, a experiment model system in expression of cellular attachment which is the essential component of the HCV entry process.

Moreover, green tea EGCG also prevented attachment of of the virus to the cell surface in ameliorated HCV infection to the host cell without effecting viral replication and virion secretion outside of the host.

Taken together, green tea and its bioactive polyphenols EGCG may be considered as a functional food in reduced risk and combined with other standard medicine for treatment of hepatitis C virus in induction of acute and chronic liver diseases.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry by Calland N1, Albecka A, Belouzard S, Wychowski C, Duverlie G, Descamps V, Hober D, Dubuisson J, Rouillé Y, Séron K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus by Chen C1, Qiu H, Gong J, Liu Q, Xiao H, Chen XW, Sun BL, Yang RG.(PubMed)
(3) A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus by Fukazawa H1, Suzuki T, Wakita T, Murakami Y.(PubMed)

Herbal Therapy: Anise, The Hepatoprotective Effects Functional Herb

Kyle J. Norton 

Anise may have a potential and substantial protective effect in preventd liver damage and diseases, some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to to Egypt and the Mediterranean region, used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Liver disease is medical condition characterized by damage or injure of the liver tissues, affecting 1 in 4 Canadians, according to statistic. The disease can also be inherited genetically from the parent.
In the evaluation of the liver protective effect of Anise in the mice induced liver toxicity by injection of carbon tetrachloride (CCl4), researchers found that Anise application significantly reduced production of reactive oxygen species in the liver tissue in initiated a chain reaction to induced tissue damage through its antioxidants activities, observed by oxidative stress markers.

The hetapoprotective effects of Anise not only protected against liver necrosis but also correlated with elevated serum IL-6 cytokine in response to infections and tissue injuries and in contributed to host defense through the stimulation of acute phase infection without inducing inflammation and activated hepatic STAT3 in faciliated lipid perioxidation.

Administered Anise also reduced oxidative stress in expression of several oxidative markers including liver Malondialdehyde (MDA), serum Alanine Aminotransferase (ALT) and aspartate aminotransferase (AST) levels through increased levels of hepatic antioxidants such as SOD and catalase in compared to non treated group.

Additionally, in the study of a total 36 Sprague-Dawley rats allocated into five groups with group I, II, and III received isotonic saline solution, olive oil and CCl4, repestively and group IV received both Silibinin and CCl4 and  group V with injection of  Anise seed extract (PFO) and CCl4, researchers at the end study found that rats treated with CCL4 exhibited a significant liver damage through observation of levels of makers of liver AST and ALT.

Rats treated with Anise seed extract (PFO) revealed a lower of serum AST and ALT levels in compared to those in the CCl4 group, although this was not as low as those in the silibinin group.

Moreover application of concentrations (1-1000 µg/ml) of essential oil and hydroalcoholic and n-hexane extracts isolated from Pimpinella anisum (anise), 1 h before the addition of 100 mM of CCl4, researchers indicated that liver cytotoxicity induced by injection of CCL4 was significant decreased by antioxidant activity of n-hexane extract with concentrations of 10-50 µg/ml.

However, administration of anise extracts and essential oil was found supprisingly in induced liver toxic effect with concentrations over 50 mµ/ml.

This result suggested that Pimpinella anisum. exhibited hepatoprotective effect against foreign substance in precipitated liver damage in doses dependent manner.

In other words, over doses of essential oil and hydroalcoholic and n-hexane extracts isolated from Anise can cause acute liver toxicity.

Taking altogether, Anise with abundant phytochemicals may be considered as a functional herb for reduced risk and assisted standard therapy for treatment of liver diseases, depending to further evaluation.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) An in vivo and in vitro investigation on hepatoprotective effects of Pimpinellaanisum seed essential oil and extracts against carbon tetrachloride-induced toxicity by Jamshidzadeh A1, Heidari R2, Razmjou M3, Karimi F3, Moein MR4, Farshad O5, Akbarizadeh AR6, Shayesteh MR3(PubMed)
(2) Hepatoprotective Effects of Pimpinella anisum Seed Extract in Rats Nureddin Cengiza Hanefi Özbekb, Aydın Himc(Pharmacologyonline 3: 870-874 (2008))
(3) Hepatoprotective effect of pimpinella anisum seed essential oil and extracts against CCl4 induced toxicity on HepG2 cellsby Akram Jamshidzadeh, Mahmoodreza Moein, Amin Reza Akbarizadeh, Niloufar Tahghighi Ahmadi(Research gate)