Wednesday 7 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments of Wernicke-Korsakoff Syndrome due to long-term alcohol abuse

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

VI. Treatments
Depending to the causes of disease, most medication are to control the symptoms
B. Treatment of  Wernicke-Korsakoff Syndrome due to long-term alcohol abuse
Wernicke-Korsakoff Syndrome is a type of dementia as a result of long term alcohol abuse causes of irreversible damage of the brain(447) due to thiamine deficiency with high morbidity and mortality(446).
Wernicke-Korsakoff Syndrome (WKS) is not a rare disorder, particularly in individuals who abuse alcohol, but there are insufficient evidence from randomized controlled clinical trials to guide clinicians in the dose, frequency, route or duration of thiamine treatment(450)
1. Initial treatment consists of reversing the thiamine deficiency by giving supplemental thiamine(448) and intravenous (IV) thiamine has little risk(449), Usually, the treatments begin with an initial intravenous or intramuscular dose, then followed by supplemental oral doses(447).
Patients with diabetes are found to associate with 15% high risk of  Wernicke-Korsakoff syndrome(451). Treatments of such patients should be taken accounted of glucose intake(453) as the combined diseases may cause disturbances of consciousness, or intoxication(452) with spiking acute serum glucose level(452).
According to State University of New York at Binghamton, treatment of Wernicke-Korsakoff Syndrome has shown to cause long-term alterations in neurogenesis(reduction of newly neuron generation) and gliogenesis(generation of non-neuronal Glial cells populations)(454).
Thiamine treatment usually can not reverse the loss of memory and intellect of Korsakoff psychosism but stopping alcohol use can prevent additional loss of brain function and damage to the  nerves(456).

2. Side effects are not limit to(455)
a. Alcohol withdrawal symptoms
b. Experience hallucinations,
c. Confusion, and/or
d. Agitation.
e. Etc.

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References   

(446) http://www.ncbi.nlm.nih.gov/pubmed/23582065
(447) http://www.ncbi.nlm.nih.gov/pubmed/20364001
(448) http://www.ncbi.nlm.nih.gov/pubmed/25201422
(449) http://www.ncbi.nlm.nih.gov/pubmed/23157990

(450) http://www.ncbi.nlm.nih.gov/pubmed/14974055
(451) http://www.ncbi.nlm.nih.gov/pubmed/22332852
(452) http://www.ncbi.nlm.nih.gov/pubmed/3596452
(453) http://www.ncbi.nlm.nih.gov/pubmed/3368823
(454) http://www.ncbi.nlm.nih.gov/pubmed/21440532
(455) http://www.healthline.com/health/wernicke-korsakoff-syndrome
(456) http://www.nlm.nih.gov/medlineplus/ency/article/000771.htm 
(456) http://www.helpguide.org/elder/parkinsons_disease.htm

Tuesday 6 January 2015

The best and Healthy recipe Mediterranean bean salad

Posted By Kyle J. Norton 
  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca 

Admittedly this salad is rather sophisticated for the average child's lunch box, but we love it so much we decide to include it anyway.
1 can (19oz./540ml) chickpeas, drained, rinsed or 2 cups cooked chickpeas
1 can (19oz./540ml) black beans, drained and rinsed or 2 cups cooked black beans
1 can (14oz./398ml) artichoke hearts packed in water, drained, rinsed and diced
1 sweet red pepper, seeded and diced
2 cups chopped kale
15 kalamata olives, pitted and chopped
8 sun-dried tomatoes, diced
3/4 cup crumbled feta cheese
1/2 cup Balsamic Vinaigrette
In large bowl combine all ingredients.
Yield serves 6 to 8. 

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(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments of Alzheimer's disease and Diminished quality of acetylcholine

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

VI. Treatments
Depending to the causes of disease, most medication are to control the symptoms 
A. Alzheimer's disease and Diminished quality of acetylcholine
A.1. Treatments of mild and moderate Alzheimer's disease and Diminished quality of acetylcholine
1. Cholinesterase inhibitors 
a. Cholinesterase inhibitors are the primary treatment, including tacrine(409)(410)(Cognex), donepezil(411)(412)(Aricept), rivastigmine(407)(408)(Exelon), and galantamine (Reminyl) for reductions in acetylcholine and acetyltransferase activity(406) induced cognitive symptoms of Alzheimer disease (AD).
According to Dr. Trinh NH and the research team at the Massachusetts General Hospital, there was no difference in efficacy among various cholinesterase inhibitors(413). Persistent drug treatment had a positive impact on AD progression in advanced disease(414). 
In the article, Cholinesterase Inhibitors, posted in the Minister of health, the inhibitors, improved the effectiveness of acetylcholine either by increasing the levels in the brain or strengthening the way nerve cells response in communication between nerve cells, may temporarily promote or stabilize the symptoms of Alzheimer's disease(415).

b. Side effects are not limit to(416)(417)
b.1. Nausea    
b.2. Diarrhea    
b.3. Vomiting    
b.4. Indigestion.     
b.5. Abdominal pain    
b.6. Loss of appetite
b.7. Fatigue
b.8. Weight loss
b.9. Etc.

A.2. Treatment of moderate and Severe Alzheimer's disease and Diminished quality of acetylcholine
1. Namenda®(418)(419)(memantine), an N-methyl D-aspartate (NMDA) antagonist(420) are the most common medication used to moderate and severe Alzheimer's disease, through it's therapeutic action in uncompetitive binding to the NMDAR for preservance of the physiological function of the receptor(421). But, according to other in 2 out of 3 six month studies, memantine showed only a small beneficial effect but not in patients with vascular dementia(422).

2. Side effects are not limit to(423)(424)
b.1. Confusion
b.2. Dizziness
b.3. Drowsiness
b.4. Headache
b.5. Insomnia,
b.6. Agitation
b.7. Vomiting
b.8. Anxiety
b.9. Etc.


3. Other medications
3.1. Anticonvulsants
a. Anticonvulsants are a diverse group of pharmaceuticals used in the treatment of seizures(425), chronic neuropathic pain(426), and the clinical syndrome of Alzheimer's disease(427) by suppressing the rapid and excessive firing of neurons(428). Some researchers suggested that seizure pathophysiology may relate to increased amyloid beta-peptide production(429), causing cytoskeletal dysfunction, cerebrovascular changes, neurotransmitter dysfunction or combinations(430). By modification of these pathophysiological pathways, anti-epileptic drugs such as sodium valproate and lacosamide may be useful in the treatment of Alzheimer's disease(431)

b. Side effects are not limit to(432)(433)
b.1. Dizziness
b.2. Drowsiness
b.3. Unsteadiness
b.4. Nausea
b.5. Vomiting
b.6. Skin rashes
b.7. Etc.

3.2. Sedatives
a. A sedative or tranquilizer is a drug that calms patients(434), reduced irritability and excitement by modulating signals within the central nervous system for neuroprotection(436). The medication are highly addictive. Benzodiazepine, one of the sedative has shown to reduce Aβ plaques through its activation on Aβ-related synaptic and behavioral impairment in AD(437).

 
b. Side effects are not limit to(438)
b.1. Stomach upset
b.2. Blurred vision
b.3. Headache
b.4. Impaired coordination
b.5. Depression
b.6. Memory loss
b.7. Drowsiness
b.8. Risk of fractures and falls(435)
b.9 Etc.

3.3. Antidepressants
a. Antidepressant is a type of psychiatric medication used to treat depression(443), including mood disorder(439), dysthymia(440)(441) and anxiety disorders(442)(443). According to Purpan-Casselardit Hospital, 34.8% of patients with AD are prescribed antidepressant foe daily use in AD(444).

b. Side effects are not limit to(445)
b.1. Dry mouth, 
b.2. Blurred vision
b.5. Drowsiness, 
b.4. Dizziness
b.5. Tremors
b.6. Sexual problems
b.7. Etc. 

The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for 
Stage 2 Alzheimer, Dementia and Memory Loss Reversal Through Scientific Evidences

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   

References  

(406) http://www.ncbi.nlm.nih.gov/pubmed/23862185
(407) http://www.ncbi.nlm.nih.gov/pubmed/23728651
(408) http://www.ncbi.nlm.nih.gov/pubmed/19370562
(409) http://www.ncbi.nlm.nih.gov/pubmed/17636619
(410) http://www.ncbi.nlm.nih.gov/pubmed/10796507
(411) http://www.ncbi.nlm.nih.gov/pubmed/16856114
(412) http://www.ncbi.nlm.nih.gov/pubmed/16437430

(413) http://www.ncbi.nlm.nih.gov/pubmed/12517232
(414) http://www.ncbi.nlm.nih.gov/pubmed/19845950
(415) http://www.health.gov.bc.ca/pharmacare/adti/clinician/cholinesterase.html
(416) http://alzonline.phhp.ufl.edu/en/reading/mmi_cholinesterase.php
(417) http://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor
(418) http://www.ncbi.nlm.nih.gov/pubmed/25523430
(419) http://www.ncbi.nlm.nih.gov/pubmed/25523285
(420) http://www.ncbi.nlm.nih.gov/pubmed/10465680

(421) http://www.ncbi.nlm.nih.gov/pubmed/21875407
(422) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003154.pub4/abstract;jsessionid=81B82BC5B10FAB9959A92CF39D439C21.d02t02
(423) http://www.medicinenet.com/memantine-oral/page2.htm
(424) http://en.wikipedia.org/wiki/Memantine
(425) http://www.ncbi.nlm.nih.gov/pubmed/23996793
(426) http://www.ncbi.nlm.nih.gov/pubmed/25479151
(427) http://www.ncbi.nlm.nih.gov/pubmed/20096151
(428) http://www.ncbi.nlm.nih.gov/pubmed/24565570
(429) http://www.ncbi.nlm.nih.gov/pubmed/23926248
(430) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385944/
(431) http://www.ncbi.nlm.nih.gov/pubmed/19557550
(432) http://www.webmd.com/bipolar-disorder/anticonvulsant-medication 
(433) http://en.wikipedia.org/wiki/Anticonvulsant 
(434) http://www.ncbi.nlm.nih.gov/pubmed/24552479
(435) http://www.ncbi.nlm.nih.gov/pubmed/18690999
(436) http://www.ncbi.nlm.nih.gov/pubmed/18311185
(437) http://www.ncbi.nlm.nih.gov/pubmed/20980585
(438) http://en.wikipedia.org/wiki/Sedative 
(439) http://www.ncbi.nlm.nih.gov/pubmed/19192442
(440) http://www.ncbi.nlm.nih.gov/pubmed/15738743
(441) http://www.ncbi.nlm.nih.gov/pubmed/25177490
(442) http://www.ncbi.nlm.nih.gov/pubmed/24497254
(443) http://www.ncbi.nlm.nih.gov/pubmed/23737423
(444) http://www.ncbi.nlm.nih.gov/pubmed/19735591
(445) http://www.webmd.com/depression/features/coping-with-side-effects-of-depression-treatment
 

The best and Healthy homemade recipe: Lemon shallot dressing

Posted By Kyle J. Norton 
  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca


According to chef James Schaeffer, the creator of this dressing, the key is to use a sharp knife to dice the shallots. A dull knife may runs the risk of bruising the shallots which is muddy the dressing.
1 tbsp. finely chopped shallots
2 tbsp. fresh lemon juice
1/2 cup canola oil
Kosher salt and white pepper
In small bowl combine shallots and lemon juice. Slowly whisk in oil until combined. Add salt and pepper to taste.
Yield almost 3/4 cup.

1000 top Paleo RecipesThe Natural Way to Make  Delicious, Healthy, 
Fat-Burning Paleo Recipes Quickly And Easily


Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home pagehttp://kylejnorton.blogspot.ca    

Monday 5 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Tyrosol and Silymarin

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
C.8. Tyrosol
Tyrosol is a phytochemical compound, a derivative of phenethyl alcohol, belongings to the group of tyrosol esters, found mostly in olive oil. The phytochemical is best known for its antioxidants in protecting the forming of free radicals and lipid oxidation causes of heart disease(383).
 1. Antioxidant effects
 Tyrosol attenuates the elevated cellular concentrations of reactive oxygen species, NO scavenging(386) and lipid peroxidation, against bacterial invasion(386), DNA damage induced by dioxin toxicity(384) and hydrogen peroxide (H2O2)(385) probably through vary antioxidant-dependent mechanisms. Neurologically, tyrosol showed to exhibit its protective effect against dopaminergic neuronal induced degradation(387) and neurotoxicity(388) in vitro model of Parkinson's disease.

2.  Alzheimer Disease

In Alzheimer Disease, tyrosol has shown to protect neuro-cells damage against amyloid-β-Induced toxicity, probably through anti inflammatory pathways(389). In women, the phytochemical also exerted its antioxidative activity(391), in removing harmful compounds from the body; reducing risk of bacterial respiratory tract, intestinal, and genital tract infections(392); suppressing LDL(392) causes of  the development of cardiovascular disease; and preventing oxidation induced diseases and conditions, such as cardiovascular disorders(392), cancer(392), osteoporosis(393)(394), Alzheimer disease(390)(395)(396)(397).


C.9.  Silymarin
Silymarin is a phytochemical in the class of Lignans (phytoestrogens), found abundantly in artichokes, milk thistle, etc.
1. Antioxidants
Silymarin showed to exert the powerful antioxidant activity into protection of cells against arsenical cytotoxicity(399), via reduced lipid hydroperoxide (LHP) formation with no RNS induction; and hepoprotective(400)(401) in ntitubercular and alcohol-induced hepatotoxicity assays in rats(400)

2. Neuroprotective effect
In impaired cognitive and neurochemical function of diabetic patients and streptozotocin induced diabetic rodents, silibinin promoted DNA protection and reduced oxidative stress in a brain specific area, in part via the activation of the HO system(402); In mouse mode with Parkinson's disease(404), treatment of the phytochemical attenuated dopamine levels induced neuro cells damage causes of  apoptosis(403) via educed brain myeloperoxidase activity associated with AD risk(405) and inflammatory signaling cells(404).

The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for 
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   

References 
(383) http://www.ncbi.nlm.nih.gov/pubmed/12548315
(384) http://www.ncbi.nlm.nih.gov/pubmed/25496362
(385) http://www.ncbi.nlm.nih.gov/pubmed/25308544
(386) http://www.ncbi.nlm.nih.gov/pubmed/24912728
(387) http://www.ncbi.nlm.nih.gov/pubmed/23790897
(388) http://www.ncbi.nlm.nih.gov/pubmed/20361927
(389) http://www.ncbi.nlm.nih.gov/pubmed/21605049
(390) http://www.ncbi.nlm.nih.gov/pubmed/22634935
(391) http://www.ncbi.nlm.nih.gov/pubmed/12058980
(392) http://www.ncbi.nlm.nih.gov/pubmed/11123850
(393) http://www.ncbi.nlm.nih.gov/pubmed/24975408
(394) http://www.ncbi.nlm.nih.gov/pubmed/25506212
(395) http://www.ncbi.nlm.nih.gov/pubmed/25461244
(396) http://www.ncbi.nlm.nih.gov/pubmed/24192327
(397) http://www.ncbi.nlm.nih.gov/pubmed/23414128
(398) http://www.ncbi.nlm.nih.gov/pubmed/20735377
(399) http://www.ncbi.nlm.nih.gov/pubmed/20637780
(400) http://www.ncbi.nlm.nih.gov/pubmed/24863352
(401) http://www.ncbi.nlm.nih.gov/pubmed/20034535
(402) http://www.ncbi.nlm.nih.gov/pubmed/21970972
(403) http://www.ncbi.nlm.nih.gov/pubmed/24607817
(404) http://www.ncbi.nlm.nih.gov/pubmed/24507644
(405) http://www.ncbi.nlm.nih.gov/pubmed/24045063

The best and Healthy homemade recipe: Asian chili mayonnaise

Posted By Kyle J. Norton 
  Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca 



1.4 cup mayonnaise
1/2 tsp. Sriracha Asian chili hot sauce or more if preferred
1/2 tsp. soy sauce
4 drops of sesame oil

In small bowl, combine ingredients thoroughly
Yield 1/4 cup


Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   

Sunday 4 January 2015

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - The Preventive Phytochemicals Gallic acid and Cinnamic acid

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
V.  Preventions
C. Phytochemicals Against Dementia
G.6.  Gallic acid
Gallic acid is a phytochemical in the class of Phenolic acids, found abundantly in tea, mango, strawberries, rhubarb, soy, etc.
1. Cytotoxic and antioxidative activities(367)
Gallic acid showed to exert its antioxidant in inhibition of free radical effects against 2,2-diphenyl-1-picrylhydrazyl(DPPH), a stable free-radical molecules(354), nitric oxide (NO) and superoxide (SO) radicals(353)(355), probably through its chelation of ferrous ions(355). In bacterias, the phytochemical extract containing gallic acid also exhibited a strong anti microbial effect(357)(358) from species of Hypogymnia physodes and Cladonia foliacea(356); In cancers, gallic acid induced tumor cytotoxic effects(357), through antiproliferative induced apoptosis(359), cell cycle arrest(362) and suppression of cancer cell-mediated angiogenesis(360), such as mitochondrial dysfunction(361). Neurologically. gallic acid reduced oxidative stress and mitochondrial dysfunction causes of the pathology of secondary neuronal damage in induction of dementia(363); its anti-aggregating effect also inhibited α-synuclein (α-syn) causes of in many neurological disorders including Parkinson's disease (PD), dementia with Lewy bodies(364).


2.  Anti inflammatory activity(367)
Gallic acid showed to inhibit inflammation(366) through its scavenging of superoxide anions, inhibition of myeloperoxidase release and activity via mediation of inflammatory process(365).

C.7. Cinnamic acid

Cinnamic acid is a phytochemical in the class of Hydroxycinnamic acids, found abundantly in cinnamon, aloe. etc.
1. Antioxidant effects
Mitochondrial oxidative damage is associated with a number of clinical disorders. Mitochondria-targeted antioxidant (TPP-OH), including cinnamic acid exhibited its antioxidant activity in protection of cells against H(2)O(2) and linoleic acid hydroperoxide-induced oxidative stress(371)(368). The phytochemical also showed a promising free radical scavenging(369) and anti-inflammatory(375), antidiabetic(374), antimicrobial(371), anticancer(377)(378), lipid-lowering(379)(380), and cardiovascular-disease-lowering activity(369)(370)(380). Neurologically, cinnamon has also been reported to have activities against neurological disorders(372)(375)(376), such as Parkinson's and Alzheimer's diseases(373)(370)

2,  Anti-platelet aggregation
 Novel ligustrazinyloxy-cinnamic acid derivatives showed to inhibit  platelet aggregation in vitro(380), and its p-amidinophenyl esters also exerted antithrombotic effects as irreversible inhibitors of the vitamin-K dependent enzymes(382) which plays an important role in the pathogenesis of chronic obstructive pulmonary disease(381).


The Memory Healer program
Discover the Secret of natural Sources Mimic of TC-5132 for 
Stage 2 Alzheimer, Dementia Reversal Through Scientific Reseach

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

For over 1000 healthy recipes, visit  http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   

References
(367) http://www.ncbi.nlm.nih.gov/pubmed/22115493
(368) http://www.ncbi.nlm.nih.gov/pubmed/22292941
(369) http://www.ncbi.nlm.nih.gov/pubmed/22512578 
(370) http://www.ncbi.nlm.nih.gov/pubmed/24817901
(371) http://www.ncbi.nlm.nih.gov/pubmed/24631135
(372) http://www.ncbi.nlm.nih.gov/pubmed/24239092
(373) http://www.ncbi.nlm.nih.gov/pubmed/24349472
(374) http://www.ncbi.nlm.nih.gov/pubmed/21550075
(375) http://www.ncbi.nlm.nih.gov/pubmed/23497886
(376) http://www.ncbi.nlm.nih.gov/pubmed/23475543
(377) http://www.ncbi.nlm.nih.gov/pubmed/23977653
(378) http://www.ncbi.nlm.nih.gov/pubmed/20653974
(379) http://www.ncbi.nlm.nih.gov/pubmed/22186322
(380) http://www.ncbi.nlm.nih.gov/pubmed/21993151
(381) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629972/