Tocopherols Process Anti-Cervical Cancer Property

By Kyle J. Norton

The cervix is the lower part of the uterus that opens at the top of the vagina.

The cervix acts as a transition area for vaginal lining (squamous epithelium) change to the uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

Researchers do not know what causes cervical cancer. Neither they can explain that women with the same health condition, family history, some are susceptible to the disease while others do not.

Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. At this stage, most women with cervical cancer do not experience any symptoms.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the statistics provided by the American Cancer Society, in 2018, approximately, 13,240 new cases of invasive cervical cancer were diagnosed. The disease causes the death of 4,170 women in the same year.

The 5-year survival rate for women with invasive cervical cancer is 92% if the cancer is detected at an early stage. About 46% of women with cervical cancer are diagnosed at an early stage.

The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers investigated the comparative plasma concentrations of three potent antioxidants, coenzyme Q(10,) alpha-tocopherol and gamma-tocopherol, in women with normal Pap smears and patients with a biopsy-confirmed histopathological lesion diagnosed as CIN or cervical cancer.

According to the history of abnormal Pap smears (n=48), and patients with histopathologically confirmed diagnoses of (a) CIN I, n=98; (b) CIN II, n=49; (c) CIN III, n=10; and (d) cervical cancer, n=25, the mean plasma levels of coenzyme Q(10), alpha-tocopherol and gamma-tocopherol were significantly lower (P<0.001,<0.001, and<0.001, respectively, in patients with various grades of CIN and cervical cancer compared with controls.

After taking other factors into accounts, such as age and smoking, both plasma coenzyme Q(10) and alpha-tocopherol concentrations showed an inverse association between histological grades of epithelial lesions.

Additional differentiation suggested that the low plasma concentrations of coenzyme Q(10) and alpha-tocopherol may be due to deficient dietary intake and free radical reactive oxygen species induced oxidative stress.

Based on the results, researchers said, "the potential of tocotrienols in improving inflammation, dyslipidemia and mitochondrial dysfunction in aging-related cardiovascular diseases...".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of cervical cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancer by Palan PR1, Mikhail MS, Shaban DW, Romney SL. (PubMed)
(2) Alpha-tocopherol and alpha-tocopheryl quinone levels in cervical intraepithelial neoplasia and cervical cancer by Palan PR1, Woodall AL, Anderson PS, Mikhail MS. (PubMed)

Omega -3 Fatty Acid, an Adjunct Therapy for Major Depressive Disorder

By Kyle J. Norton


Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness.

In other words, depression is a common and serious psychological illness, affecting the physical and mental functions of patients, including the ways patients feel, think and act.

Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. 

Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself. The mild case of depression can be defeated by a variety of self-care techniques. 

Others may require the treatment of medication, such as antidepressant medications and psychotherapy that help to reduce and sometimes eliminate the symptoms of depression.

There are many causes associated with the onset of depression, including genetics, changes in hormone levels, certain medical conditions, stress, grief or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome.

The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, loss of interest in friends, family, favorite activities, and sex.

Some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming themselves.

Major depressive disorder (MDD), is a medical condition characterized by a persistent feeling of sadness or a lack of interest in outside stimuli.

Conventionally, as of today, there is no way to prevent major depression. However, early diagnosis can be helpful to reduce symptoms and the risk of recurrence.

A combination of psychotherapy and medication has been found to improve symptoms and quality of life in patients with major depressive disorder, including serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa) and escitalopram.

Antidepressants including bupropion (Wellbutrin), venlafaxine (Effexor), mirtazapine (Remeron) and duloxetine (Cymbalta) can be effective but they take at least two to six weeks to see the improvement

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of depression, researchers investigated the effects that PUFAs on the brain and the immune system, including the effects of proinflammatory cytokines and oxidative stress, and their therapeutic benefits in major depressive disorder (MDD) and bipolar disorder.

The study included the search of medical literature published PubMed and Google Scholar, with no restrictions on the publication dates or geographically, including the facilities in Washington, DC, and Davis, California.

According to the tested analysis,
* Patients with major depressive disorder (MDD) demonstrated a highly inflammatory state that contributes to many significant health complications.

* The application of omega-3 PUFAs has been found to treat those issues.

Furthermore, omega-3 fatty acids showed strong therapeutic benefits in the treatment of both MDD and bipolar disorder and are effective as a monotherapy and, particularly, as an adjunct therapy. 

Based on the findings, researchers said, "The efficacy of omega-3 supplementation is clearly useful in promoting better health overall and supplementation should be encouraged in the primary care setting."

And "A meta-analysis exploring an adjunct treatment of supplemental eicosapentaenoic acid or docosahexaenoic acid is likely to yield the greatest benefits to psychiatric conditions and provide an answer to proper dosing regimens".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered an adjunct treatment of the major depressive disorder (MDD), pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Psychoneuroimmunological Role of Omega-3 Polyunsaturated Fatty Acids in Major Depressive Disorder and Bipolar Disorder by Rutkofsky IH, Khan AS, Sahito S, Kumar V. (PubMed)
(2) Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder by Mocking RJ1, Harmsen I1, Assies J1, Koeter MW1, Ruhé HG1,2, Schene AH. (PubMed)

Cabbage, the Natural Probiotics for the Improvement of Digestive Health

By Kyle J. Norton

Probiotics are good bacteria that not only balance the ratio of gut microbiota in the intestine but also react with other body systems to provide optimal health in the human.

The most common types of probiotics are lactobacilli (like Lactobacillus acidophilus and Lactobacillus GG), bifidobacteria (like Bifidobacterium Bifidus) and some yeasts (like Saccharomyces boulardii).

Although all probiotics shared the same functions to improve the gastrointestinal microbiome community, different probiotics have different effects.

Probiotics have been found to improve the ratio of gut microbiota which plays a critical role in the digestion of certain foods that the stomach and small intestine have not been able to digest, in the production vitamins, improvement of digestive functioning and modulation of the immune function.

More precisely, probiotics have been found to process a number of health benefits, including lowering blood pressure, cholesterol, and glucose, improved lactose tolerance, and stomach health, weight control and promoted wound healing.

* In immunity, probiotics stimulate the immune function against inflammatory immune disorders.

* In the digestive system, probiotics protect the gut against gastrointestinal diseases and non-gastrointestinal diseases.caused by overexpression of bad bacteria.

* In metabolism, probiotics influence the nutrient extraction from the diet, thus reducing the risk of obesity and obese complication.

* Neurologically, probiotics control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

However, the use of antibiotics has been found to damage the gut ecosystem, leading to certain chronic illnesses such as inflammatory bowel disease, obesity, cancer, and autism.

Unhealthy gut microbiota has been found to
* Decrease the interaction with the immune function against inflammatory immune disorders.

* Increase the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Reduce nutrient extraction from the diet, thus increasing the risk of obesity and obese complication.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food that promotes the digestive functioning, researchers compared the activity of the probiotics on the novel lactic acid bacteria (LAB) isolated from the fermentative potential for preparing Korean cabbage kimchi and Lactobacillus Plantarum KCC-41 strain.

According to the tested differentiation, 

* Lactobacillus Plantarum KCC-41 strain was able to inhibit pathogenic fungal spore formation and was susceptible to common commercial antibiotic drugs.

* The encapsulated KCC-41 strain could effectively lead to kimchi fermentation in terms of reducing its pH and dominating bacterial count.

*  LAB strain survives in vitro simulated gastrointestinal fluid.

Based on the results, researchers wrote, "It also significantly increased organic acid production than non-encapsulated LAB (KCC-41) for cabbage kimchi samples".
Taken altogether, Korean cabbage kimchi may be considered probiotics for the promotion of digestive functioning, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Microencapsulation of endophytic LAB (KCC-41) and its probiotic and fermentative potential for cabbage kimchi by Song CE1, Kuppusamy P2, Jeong YI3, Shim HH4,5, Lee KD. (PubMed)

Tocopherols the Potential Treatment of Hyperglycemia, Researchers Find

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly as a result of poor diet and/or poor practice of medicine intake and/or insulin injection. However, the condition can also occur to people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body's inability to make enough insulin.

Most cases of hyperglycemia can be controlled by the following diabetes guidance.

The most common symptoms of hyperglycemia are increased thirst frequent urination, fatigue (weak, and unintended weight loss. Some patients may also experience symptoms of headaches, trouble concentrating and blurred vision.

Long-term untreated hyperglycemia may induce complications that affect the eyes, kidneys, ner, es and heart.

In severe cases, hyperglycemia can also lead to serious complications that require emergency care, such as a diabetic coma.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the antioxidant and anti-inflammatory activities of a γ-tocopherol-rich mixture of tocopherols (γ-TmT) against vascular dysfunction caused by postprandial hyperglycemia.

According to the analysis of a randomized, crossover study, healthy men (n=15; 21.8 ± 0.8 years) completed a fasting oral glucose challenge (75 g) with or without prior supplementation of γ-TmT (5 days).
* Supplementation of γ-TmT increased (P<.05) plasma γ-T by threefold and γ-carboxyethyl-hydroxychroman by more than ninefold without affecting α-T, glucose, arginine or ADMA a a naturally occurring product of metabolism found in human circulation.

* Postprandial flow-mediated dilation (FMD) decreased 30%-44% (P<.05) following glucose ingestion, but was maintained with γ-TmT.

* Supplementation of γ-TmT also attenuated postprandial increases in MDA associated with oxidative stress markers that occurred following glucose ingestion.

* Plasma arginine decreased (P<.05) in both trials to a similar extent regardless of γ-TmT supplementation. However, the ratio of ADMA/arginine increased associated with the potential marker of cardiovascular diseases [time-dependently in both trials (P<.05), but to a lesser extent following γ-TmT supplementation (P<.05).

* Inflammatory proteins were unaffected by glucose ingestion or γ-TmT.

Collectively, researchers said, " these findings support that short-term supplementation of γ-TmT maintains VEF during postprandial hyperglycemia possibly by attenuating lipid peroxidation and disruptions in NO• homeostasis, independent of inflammation".

Taken altogether, tocopherols may be considered adjunct therapies in the treatment of postprandial hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia by Mah E1, Noh SK, Ballard KD, Park HJ, Volek JS, Bruno RS. (PubMed)

Ashwagandha, the Anti Bacterial Infection Functional Remedy

By Kyle J. Norton

The bacterial infection is the infection caused by bacteria. Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has made many of them resistant to antibiotics.

There are trillions of strains of bacteria in the world, but only a few of these cause diseases in humans. Some of them live inside our gut.

The most common symptoms of bacterial infection are redness and heat, swelling, fever, pain at the site of infection.

In severe cases, the patient may also experience symptoms of swollen lymph glands.

Most cases of bacterial infection can be treated successfully if the types of bacteria that cause the infection are identified.

There are a number of risk factors associated with the onset of bacterial infection, some researchers suggested that people with a weakened immune system may increase the prevalence of bacterial infection.

Dr. van Aalst, the lead scientist wrote, "Patients with a weakened immune system due to immunosuppressive treatment are at increased risk of infection with Streptococcus pneumonia".

And, " in patients treated with immunosuppressive medication and compared to controls, the initial serologic response to the pneumococcal conjugate vaccine (PCV) and pneumococcal polysaccharide vaccine (PPSV) is impaired. Moreover, this impaired response was more profound after PCV than after PPSV".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the prevention and treatment of infectious diseases, researchers examined the antibacterial effects of aqueous and alcoholic extracts of the plant (root as well as leaves) against a range of bacteria.

According to the tested differentiation, the methanolic extract sub-fractionated using various solvents and the butanoic sub-fraction showed maximum inhibitory activity against a spectrum of bacteria including Salmonella typhimurium.

The application of both aqueous and alcoholic extracts is considered safe compared to the synthetic antibiotic (viz. chloramphenicol), as these extracts did not induce lysis on incubation with human erythrocytes.

In salmonellosis in Balb/C mice, extracts isolated from plants (both root and leaves) also demonstrated a strong effect on tested salmonellosis.

Finally, researchers said, " Oral administration of the aqueous extracts successfully obliterated salmonella infection in Balb/C mice as revealed by increased survival rate as well as less bacterial load in various vital organs of the treated animals".

Taken altogether, Ashwagandha may be considered a functional herb for the treatment of bacterial infections, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis by Owais M1, Sharad KS, Shehbaz A, Saleemuddin
M. (PubMed)
(2)  The effect of immunosuppressive agents on immunogenicity of pneumococcal vaccination: A systematic review and meta-analysis by van Aalst M1, Langedijk AC1, Spijker R2, de Bree GJ Grobusch MP4, Goorhuis A. (PMC)

Broccoli Processes Anti-Metastatic Activities Via Innate Immune Cell Activation

By Kyle J. Norton

The immune system is biological structures of an organism that protects us against disease by identifying and killing pathogens, including bacteria, viruses, parasites, etc. and tumor cells, including irregular cell growth, cancer cells.

In most cases, the immune system does a great job to keep us healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

However, during the process of their functions, they may induce the production of free radicals and a chain of free radicals that can be harmful to our bodies. including the production of pro-inflammatory cytokines in the acute phase of infection.

In other words, through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interactions.

In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines to the site of the damage.

The inflammatory cytokines not only play a critical role in stopping the stimuli from entering into the body but also speeds up the wound healing through growth factors.

The innate immune system also can destroy the damaged cells such as cancer cells through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53, a tumor suppressor.

Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.

Metastasis is the process to induce the development of secondary malignant growths at a distance away from primary cancer.

Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.

According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the anti-metastatic activities of polysaccharides in broccoli, purified polysaccharides (BCE-I, -II, and -III) isolated by fractionation of broccoli enzyme extracts and subsequent ethanol precipitation.

More precisely, BCE-I mainly consisted of galactose and arabinose, whereas BCE-II mainly consisted of galacturonic acid and rhamnose, and BCE-III mainly consisted of rhamnose and galactose.

According to the results of the analysis, compared to other compounds, BCE-I showed the greatest enhancement of tumor necrosis factor-α, interleukin (IL)-12, and IL-6 secretion in the induction of cytotoxicity on stimulation of murine peritoneal macrophages.

Furthermore, intravenous (i.v.) administration of BCE-I enhanced the lethal activity of natural killer (NK) cells on YAC-1 tumor cells significantly and dose-dependently in an ex vivo experiment.

Moreover, Ii an experimental model using lung metastasis of Colon26-M3.1 carcinoma cells, prophylactic i.v., oral administration of BCE-I significantly and dose-dependently inhibited lung metastatic activity.

Based on the evidence, researchers said, "These results indicated that BCE-I has potent antitumor metastatic activity and that its anti-metastatic activity has relevance to the stimulation of NK and other immune cells".

Taken altogether,  broccoli processes anti-metastatic activities via innate immune cell activation, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Rhamnogalacturonan-I-Type Polysaccharide Purified from Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation by Kwak BS1, Hwang D2,3, Lee SJ1, Choi HJ4, Park HY5, Shin KS. (PubMed)

Cranberry Modulates the Expression of Oxidative Stress

By Kyle J. Norton

Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissues.

Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress presented in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. 

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers investigated the effects of cranberry polyphenolic fractions in oxidative stress (OxS), on intestinal Caco-2/15 cells.

According to the tested analysis, cranberry extracts pre-treatment in Caco-2/15 cells not only showed a strong activity iron/ascorbate lipid peroxidation but also inhibited lipopolysaccharide in the mediation of the production of inflammation in pro-inflammatory cytokines such as TNF-α and interleukin-6.

Furthermore, cranberry extracts pre-treatment also inhibited the inflammatory symptoms such as pain associated with the overexpression of enzyme cyclo-oxygenase-2 and hormone prostaglandin E2.

Moreover, Cranberry polyphenols (CP) fractions regulated the levels of antioxidant enzymes Nrf2 and levels of a pro-inflammatory cytokine such as nuclear factor κB activation.

Taken altogether, cranberry may be considered a remedy for the management of oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions by Denis MC, Desjardins Y1, Furtos A2, Marcil V3, Dudonné S1, Montoudis A3, Garofalo C3, Delvin E, Marette A, Levy E. (PubMed)