Tocopherols the Potential Treatment of Hyperglycemia, Researchers Find

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly as a result of poor diet and/or poor practice of medicine intake and/or insulin injection. However, the condition can also occur to people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body's inability to make enough insulin.

Most cases of hyperglycemia can be controlled by the following diabetes guidance.

The most common symptoms of hyperglycemia are increased thirst frequent urination, fatigue (weak, and unintended weight loss. Some patients may also experience symptoms of headaches, trouble concentrating and blurred vision.

Long-term untreated hyperglycemia may induce complications that affect the eyes, kidneys, ner, es and heart.

In severe cases, hyperglycemia can also lead to serious complications that require emergency care, such as a diabetic coma.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the antioxidant and anti-inflammatory activities of a γ-tocopherol-rich mixture of tocopherols (γ-TmT) against vascular dysfunction caused by postprandial hyperglycemia.

According to the analysis of a randomized, crossover study, healthy men (n=15; 21.8 ± 0.8 years) completed a fasting oral glucose challenge (75 g) with or without prior supplementation of γ-TmT (5 days).
* Supplementation of γ-TmT increased (P<.05) plasma γ-T by threefold and γ-carboxyethyl-hydroxychroman by more than ninefold without affecting α-T, glucose, arginine or ADMA a a naturally occurring product of metabolism found in human circulation.

* Postprandial flow-mediated dilation (FMD) decreased 30%-44% (P<.05) following glucose ingestion, but was maintained with γ-TmT.

* Supplementation of γ-TmT also attenuated postprandial increases in MDA associated with oxidative stress markers that occurred following glucose ingestion.

* Plasma arginine decreased (P<.05) in both trials to a similar extent regardless of γ-TmT supplementation. However, the ratio of ADMA/arginine increased associated with the potential marker of cardiovascular diseases [time-dependently in both trials (P<.05), but to a lesser extent following γ-TmT supplementation (P<.05).

* Inflammatory proteins were unaffected by glucose ingestion or γ-TmT.

Collectively, researchers said, " these findings support that short-term supplementation of γ-TmT maintains VEF during postprandial hyperglycemia possibly by attenuating lipid peroxidation and disruptions in NO• homeostasis, independent of inflammation".

Taken altogether, tocopherols may be considered adjunct therapies in the treatment of postprandial hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia by Mah E1, Noh SK, Ballard KD, Park HJ, Volek JS, Bruno RS. (PubMed)