Wednesday 24 December 2014

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system - Genetic mutation Causes of Dementia

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia



About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
II. Causes of dementia
I. Genetic Mutation causes of dementia
Genetic mutation is a condition of changes of DNA structure and alteration in the inherited nucleic acid sequence of the genotype(169). There are always a concern of some dementia patients with inherited trails for passing them to their children.

1. Linkage of Dementia with Lewy bodies (DLB) to 2q35-q26 
 Genetic mutation of chromosome 2q35-q36 Lewy bodies (DLB) are multiplex due to its complex mechanism than generally monogenic disorders. Identifying the first familial DLB gene may contribute to an entry point of DLB pathology, according to Belgian family,researchers(170)

2. VCP gene R155H mutation
Some patients in the same family with frontotemporal dementia (FTD) have been diagnosed with high risk of cognitive decline due to the recurrent R155H mutation, according to University of Genova(171).


3. Genetic mutation and Alzheimer's disease
4 genes have been identified to affect development of AD. with the amyloid precursor protein (APP ) gene, presenillin gene (PSEN-1), and presenillin gene (PSEN-1)) affect younger people, and apolipoprotein E (APOE ) iaffects older people(172).

4. Chromosome 3 (FTD-3) caused by a truncating mutation in CHMP2B
Presymptomatic CHMP2B mutation  was found to associated to significantly decreased cerebral blood flow (CBF) affecting brain capillaries(173) and contributing to the early on set of dementia.

5. Mutations in the NOTCH3
Mutations in the NOTCH3 gene are responsible for hereditary stroke disorder, contributed to an adult onset of hereditary ischemic stroke, vascular dementia and psychiatric disorders(174).

6. Etc.
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References
(170) http://www.ncbi.nlm.nih.gov/pubmed/20164589 
(171) http://www.ncbi.nlm.nih.gov/pubmed/18341608
(172) http://www.dementiaguide.com/aboutdementia/typesofdementia/geneticmutations/
(173) http://www.ncbi.nlm.nih.gov/pubmed/22422914
(174) http://www.ncbi.nlm.nih.gov/pubmed/22053260

The Best and healthy Kid recipe: Nut free trail mix

Posted By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca

The chocolate chips in this recipe are optional, although they do go a long way in getting little ones to gobble up this nutritious snack. If your school permits nuts, you can add 1 cup of peanuts to the mix.
1 cup toasted sunflower seeds
1/2 cup toasted pumpkin seeds
1/2 raisins
1/2 cup dried cranberries
1/2 cup chocolate chip(optional)
In bowl, combine ingredients. Store in airtight container
Yield 3 cups


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Tuesday 23 December 2014

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system - Life Style Causes of Dementia

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

II. Causes of dementia
H. Life Style causes of Dementia
 1. Unhealthy diet 
Unhealthy lifestyle choices lead to an increasing incidence of obesity, diabetes mellitus type II, hypertension and disorder of the metabolic syndrome(159)(160), are found to associated the risk of AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia(161).

2. Psychological and Neurological effects
Dysfunctional mind may be associated to dementia due to its effects on the cognitive profile of ALS, a subclinical behavioural-variant frontotemporal dementia (bvFTD(162). Stress, anxiety, depression(163), negative thoughts(162), unhealthy life style(159)(160), unwholesome diet(161) may lead to memory, intellect, attention, thinking, comprehension and personality, with preservation of normal level of consciousness deficits(164)

3. Excessive alcohol drinking
Moderate alcohol drinking of less than 2 cups for men and 1 cups for women are said to offers possible health benefits(165), but binge drinking in midlife and excessive alcohol use  are associated with an increased risk of dementia, according to the follow-up, 103 participants had developed dementia(166), including central pontine myelinolysis, Marchiafava-Bignami disease(167).

4. Smoking
Smoking is a risk factor for several life-threatening diseases, but its long-term afflicts of dementia is controversial and understudied. According to University of Eastern Finland, heavy smoking in midlife was found to associate with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later, in a follow up study of a total of 5367 people diagnosed with dementia (including 1136 cases of AD and 416 cases of VaD)(168).

5. Etc.
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References
(159) http://www.ncbi.nlm.nih.gov/pubmed/25488565
(160) http://www.ncbi.nlm.nih.gov/pubmed/24974749
(161) http://www.ncbi.nlm.nih.gov/pubmed/18466323 
(162) http://www.ncbi.nlm.nih.gov/pubmed/25476003
(163) http://www.ncbi.nlm.nih.gov/pubmed/25490073
(164) http://www.ncbi.nlm.nih.gov/pubmed/22408297 
(165) http://www.mayoclinic.com/health/alcohol/SC00024
(166) http://www.ncbi.nlm.nih.gov/pubmed/16222166
(167) http://www.ncbi.nlm.nih.gov/pubmed/25307574 
(168) http://www.ncbi.nlm.nih.gov/pubmed/20975015

Premenstrual Syndrome(PMS): Causes of Breast Tenderness

By Kyle J. Norton 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Premenstrual syndrome effects over 70% to 90% of women before menopause in the US and less for women in Southeast Asia because of their difference in living style and social structure. It is defined as faulty function of the ovaries related to the women's menstrual cycle, it effects a women's physical and emotional state, and sometimes interferes with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.

Breast tenderness effects more than 70% of women in the US alone. Sometimes, it is so painful that some women afraid to be hugged and are experience uncomfortable during sleep.

1. Caffeine
Caffeine is a stimulant, containing methylxanthines, a chemical exhibited the symptoms of PMS(4) including breast tenderness(5)(6), breast pain(1)(2) and induced fibrocystic breast disease(2)(3). Reducing intake of foods containing caffeine such as coffee, tea 3 to 4 days before period may help to reduce the symptoms of breast tenderness and pain(1)(4).

2. Stress
Prolactin produced abundant by during baby feeding(9), may also be released during prolong period of stress(7)(8) to cause breast tenderness(10)(11)(12) for some women with PMS.

2. Hormone imbalance
Some women may experience breast changes during menstrual cycle(13). The problem is linked to the cycle, caused by the fluctuation of levels of estrogen and progesterone as resulting of hormonal imbalance(14).

3. Sluggish Liver
Liver is important in carbohydrate(15), fat(16) and protein(17) metabolism. Sluggish liver causes abnormal function of liver in regulating the levels of Omega 3 and 6 fatty acids(18), and induced imbalance of levels of PGE2 induced breast tenderness and pain(19)(20).

4. Nutrients deficiency
a)Vitamins and minerals deficiency
For what ever reason, women with pre menstrual syndrome are found to have low levels of micronutrients(22)(23)(24), of that can lead to over production of levels of PGE2(24) which causes PMS including breast tenderness and pain(19)(20).

b) Omega 3 fatty acid deficiency
As we mention before, Omega 3 fatty is important to inhibit the levels of PG2(16). Deficiency of Omega 3 fatty acid causes high levels of PGE2(16) in the bloodstream induced breast tenderness and pain(19)(20).

5. Prostaglandins hormone
Balancing of prostaglandins hormone is vital in regulating the uterus muscles(21) during menstrual cycle. If the levels of PGE2(19)(20) of the prostaglandins is getting too high, it may cause breast tenderness and breast pain(19)(20) for women with PMS.

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References
(1) http://www.ncbi.nlm.nih.gov/pubmed/2927749
(2) http://www.ncbi.nlm.nih.gov/pubmed/6474353
(3) http://www.ncbi.nlm.nih.gov/pubmed/3314435
(4) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1349785/?page=1
(5) http://www.ncbi.nlm.nih.gov/pubmed/3296263
(6) http://www.ncbi.nlm.nih.gov/pubmed/12725453
(7) http://www.ncbi.nlm.nih.gov/pubmed/25466832
(8) http://www.ncbi.nlm.nih.gov/pubmed/24657520
(9) http://www.ncbi.nlm.nih.gov/pubmed/19224938
(10) http://www.ncbi.nlm.nih.gov/pubmed/22963023
(11) http://www.ncbi.nlm.nih.gov/pubmed/2139769
(12) http://www.ncbi.nlm.nih.gov/pubmed/1294345
(13) http://www.ncbi.nlm.nih.gov/pubmed/15982388
(14) http://www.ncbi.nlm.nih.gov/pubmed/600762
(15) http://www.ncbi.nlm.nih.gov/pubmed/6380304
(16) http://www.ncbi.nlm.nih.gov/pubmed/18477307
(17) http://www.ncbi.nlm.nih.gov/pubmed/9022955
(18) http://www.ncbi.nlm.nih.gov/pubmed/17144882
(19) http://www.ncbi.nlm.nih.gov/pubmed/12199620
(20) http://www.ncbi.nlm.nih.gov/pubmed/3858547
(21) http://www.ncbi.nlm.nih.gov/pubmed/24742728
(22) http://www.ncbi.nlm.nih.gov/pubmed/10763903
(23) http://www.ncbi.nlm.nih.gov/pubmed/11684393
(24) http://www.ncbi.nlm.nih.gov/pubmed/3354488
(25) http://www.ncbi.nlm.nih.gov/pubmed/10448487

Bacon, pea and cheese quiche

Posted By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca

1 egg, beaten
1tbsp. cooked bacon, crumbled
1 tbsp. frozen peas, thawed
1 tbsp. shredded cheddar cheese
Preheat oven to 350 degree. Grease 1 muffin tip cup with either non hydrogenated margarine or canola oil. Fill remaining cups with water.
In a small bowl, combine egg, bacon, peas and cheese. Pour into greased muffin cup.
Bake for 20 minutes or until quiche is puffed and egg is set. Transfer muffin tin to a wire rack to cook for 5 minutes. With a knife, gently loosen edges of quiche and remove from pan.
Serves 1

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Monday 22 December 2014

(Preview) Most common diseases of 50 plus - Diseases of Central Nervous system - Medication Causes of Dementia

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

         Diseases of Central Nervous system

                           Dementia


About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

II. Causes of dementia
G. Medication Causes of Dementia
As aging, accumulation of toxins of certain medication used to treat certain diseases, such as antidepressants, sedatives, cardiovascular drugs and anti-anxiety medications may cause increased risk of cognitive dysfunction, including dementia-like symptoms(146).
1. Antidepressants, selective serotonin reuptake inhibitors, antipsychotics and benzodiazepines
An Antidepressant is a psychiatric medication used to treat mood disorders, such as major depression and dysthymia and anxiety disorders. According to Johns Hopkins Bayview Medical Center. all antidepressants, selective serotonin reuptake inhibitors (SSRIs), antipsychotics (atypical and typical), and benzodiazepines overtime of medication exposure, induced more rapid cognitive and functional decline in AD(147).

2. Anti-inflammatory drugs (NSAIDs)
Risks for AD and all-cause dementia were lower significantly with the use of any NSAIDs, but there is a weak link associated between usage of NSAIDs and the risk of cognitive impairment but not dementia (CIND(148)

3. Cannabis
Cannabis has been  used for the treatment of a number of conditions, including neuropathic pain, treatment of spasticity associated with multiple sclerosis, and chemotherapy-induced nausea, etc,. According to University of Western Australia, chronic use of cannabis may impair intellectual abilities, probably through some causal pathways(149).

4.  Hallucinogens
Hallucinogens, psychedelic drugs, used primary action in altered cognition and perception, may cause distortion of sensory perception, and other psychic and somatic effects, including sweating, heart palpitations, blurring of vision, memory loss, trembling, and itching(150).

5. Risperidone 
The most prescribed antipsychotic medication has shown to increase risk of dementia(152) and other cognitive dysfunction, depending to overtime chronic exposure(151).

5. Others
a. Corticosteroids
Corticosteroids are synthetic drugs closely resemble cortisol, a steroid hormones produced by the adrenal glands to assist the physiologic processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, behavior, etc. but an excessive usage showed to increase risk of progressive cognitive decline(153)(154).

b. Antibiotics 
 Antibiotics are medication taken to treat a variety of infections found to be associated with increased risk of psychomotor deceleration, delirium and psychosis in elderly patients(155)(156).

c. H2-receptor antagonists 
H2-receptor antagonists are medicines taken to reduce the amount of acid the stomach by blocking one important producer of histamine2,  may cause acute and chronic cognitive impairments(157)(158).

d. Etc.

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References
(146) http://www.ehow.com/how-does_5510964_prescription-drugs-cause-dementia.html
(147) http://www.ncbi.nlm.nih.gov/pubmed/22374884
(148) http://www.ncbi.nlm.nih.gov/pubmed/22546354
(149) http://www.ncbi.nlm.nih.gov/pubmed/16240487
(150) http://serendip.brynmawr.edu/exchange/node/1880
(151) http://www.ncbi.nlm.nih.gov/pubmed/24901289
(152) http://www.ncbi.nlm.nih.gov/pubmed/20025088
(153) http://www.ncbi.nlm.nih.gov/pubmed/25265527
(154) http://www.ncbi.nlm.nih.gov/pubmed/25191904
(155) http://www.ncbi.nlm.nih.gov/pubmed/19097002
(156) http://www.ncbi.nlm.nih.gov/pubmed/16696772
(157) http://www.ncbi.nlm.nih.gov/pubmed/23209067
(158) http://www.ncbi.nlm.nih.gov/pubmed/10459729


The best and healthy Kids recipe: Mini salmon patties

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Recipe attributed to "Good Food to go- healthy lunch your kids will love" by Brenda Bradshaw and Cheryl Mutch, M.D. published by Random house Canada. You can view its website at randomhouse.ca

These are a wonderful lunch box snack. They are exceptionally versatile and freeze well. They can be placed on a salad, wrapped in a pita pocket or serve on their own with a little tzatziki for dipping. Try doubling the recipe and freezing the extras so you have a plenty on hand.
2tbsp. canola oil
1/2 cup diced onion
1/2 cup celery, diced
1 garlic glove, minced(optional)
2 cans(7nabd 1/2 oz. 213g each) salmon, drained and skin removed
2 large eggs, beaten
1/2 cup whole wheat bread crumbs
1 squeeze fresh lemon juice
1/2 round tsp. chopped fresh dill(optional)
1/2 tsp. ground pepper
1/2 tsp. lemon zest
Heat 1 tbsp. of oil in skillet over medium heat. Add onions and celery and saute for 8 minutes.
Add garlic(if using) and sauté for another 2 minutes, being careful not to burn garlic.
In bowl, combine onion mixture, salmon, eggs, bread crumbs, lemon juice, dill, pepper and lemon zest.
Shape 3 tbsp. salmon mixture into patty. Repeat with remaining salon mixture.
Heat remaining 1 tbsp. of oil in skillet, and cook patties for 4 -6 minutes per side or until golden with slightly crispy coating.
Yield approximately 12 salmon patties.

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Optimal Health And Loose Weight

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