Kyle J. Norton
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else in the body instead of the inside of the uterus.
More precisely, during the maturation, the layer of endometriosis lining on the inside of the uterus is normally expelled, and some of the endometriosis tissues grow somewhere else in the body.
Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of the peritoneum, in the ovaries, and on the surface of the uterus's outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.
According to the statistics, 20% of reproductive-age women with endometriosis present without symptoms, and 55% of women have developed the new onset of severe menstrual cramps.
Additionally, endometriosis also induces sub-fertility (less fertile than a normal couple) in 25% of women.
Conventionally, endometriosis is treated either by medications or surgery, including
* Medication for pain with an aim to ease painful menstrual cramps.
* Hormone therapy may be accompanied by pain medication also with an aim to reduce menstrual pain such as hormonal contraceptives. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Progestin therapy. and aromatase inhibitors.
In a surgery perspective,
* In women who want to get pregnant, surgery removes the endometriosis implants while preserving the uterus and ovaries.
* Hysterectomy with removal of the ovaries may be performed if pregnancy is not a concern.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of endometriosis, researchers examined the effects of quercetin (3,3',4',5,7-pentahydroxyflavone), a major dietary flavonol found in the onion on the risk of endometriosis.
In human endometriosis cell lines (VK2/E6E7 and End1/E6E7 cells),
* Quercetin inhibited the proliferation and induced the cell cycle arrest.
* Administration of quercetin not only induced cell apoptosis with DNA fragmentation, and loss of mitochondrial membrane potential but also exhibited cytotoxicity of reactive oxygen species production in the tested cell lines.
* Quercetin also suppressed the expression of signaling pathways associated with endometrial cell survival and growth.
On endometriosis auto-implanted mouse models,
* Administration of quercetin also promoted the antiproliferative and anti-inflammatory effects.
* Quercetin injection also attenuated the proliferation with sub-G0/G1 cell cycle arrest and increased the apoptosis of VK2/E6E7 and End1/E6E7 cells by inhibiting the gene associated with the onset and progression of endometriosis.
In other words, quercetin inhibited the risk and onset of endometriosis by the increased expression and decrease expression of Micro RNA (miRNA) involved in the initiation and progression of endometriosis in vitro and vivo.
Dr. Park S, the lead scientist said, "Hence, quercetin may potentially act as a natural therapy to reduce and treat human endometriosis".
Taken together, onion processed with an abundantly high amount of quercetin may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits the proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo by Park S1, Lim W2, Bazer FW3, Whang KY4, Song G. (PubMed)
Monday, 30 October 2023
#Ginger Bioactive Compounds and Extract Process Anti Lung Cancer Activity, Researchers Show
Kyle J. Norton
Scientists may have found a pungent spice which processes the potential to treat lung cancer, according to studies.
Lung cancer is a medical condition characterized by irregular cell growth in the lung tissue.
In Canada, according to the statistics, lung cancer is the leading cause of death in both men and women. Lung cancer accounts for 26.7% of all deaths from cancer and 6.5% of all mortality.
The 5-year survival rate for people with stage IB NSCLC is about 68%.
At the advanced stage, the lung cancer cell may suppress the nearby blood vessels and nerves leading to vomiting blood and localized severe pain accompanied by other general symptoms of cancer such as weight loss, reduced appetite.
In this stage, lung cancer also can travel a distance away to infect other healthy cells of tissue and organs, leading to secondary metastasis.
The most common glands and organs of lung cancer metastases are the adrenal gland, bones, brain, and liver.
Although there are many factors associated with the onset of lung cancer, some researchers suggested that current and past smoking accounts for most of the cases. The risk of developing lung cancer is about 23 times higher in male smokers compared to non-smokers, epidemiologically.
Dr. Ozlü T, the lead scientist in examining the risk of lung cancer from smoking, wrote, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers. In recent decades, there has been a shift from squamous and small cell lung cancer types to adenocarcinoma, due to increasing rates of smoking among the female population and rising light cigarette usage".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of lung cancer with no side effects compared to chemo medication examined the anti-lung cancer of bioactive compounds isolated from ginger.
[6]-shogaol, [6]-paradol and [6]-gingerol, potentiate the anti-NSCLC activity, however, [6]-shogaol showed the greatest inhibitory effects on the NSCLC cell proliferation and anchorage-independent growth.
[6]-Shogaol also induced cell cycle arrest (G1 or G2/M) and apoptosis as well as the cascades associated with the programming cell deaths.
Furthermore, [6]-shogaol inhibited protein (Akt kinase activity), associated with cancer proliferation and survival In NCI-H1650 lung cancer cells by inhibiting the regulator involved in cell cycle progression.
Dr. Myoung Ok Kim and colleagues in the final report said, "The current study clearly indicates that [6]-shogaol can be exploited for the prevention and/or treatment of NSCLC".
In order to reveal more information about ginger anti-lung cancer activity, researchers examined the [6]-gingerol and [6]-shogaol and a ginger extract with a high level of shogaols (GEHS) against lung cancer cells.
[6]- shogaol has greater growth inhibitory activity (about 10-fold) on lung and colon cancer cell lines than [6]- gingerol.
Shogaols of ginger preparations and GEHS has a stronger cancer-preventive effect, compared to other ginger extracts.
The inhibitory activities of GEHS and extract from fresh ginger, as well as [6]-shogaol and [6]-gingerol inhibited an NNK-induced lung carcinogenesis model in A/J mice.
These results provide the basic information on key active cancer preventive constituents in ginger extracts. The development of a standardized and more active ginger extract preparation will facilitate future pre-clinical and clinical studies on the health benefits of ginger extracts, according to the author.
Taken together, ginger processed with a high amount of bioactive compounds may be considered a function alternative for prevention and combined primary therapy for the treatment of lung cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 by Myoung Ok Kim, 1 , 2 , † Mee-Hyun Lee, 1 , 3 , † Naomi Oi, 1 , † Sung-Hyun Kim, 1 , 2 , †Ki Beom Bae, 1 Zunnan Huang, 1 , 4 Dong Joon Kim, 1 , 5 Kanamata Reddy, 1 Sung-Young Lee,1 , 6 Si Jun Park, 2 Jae Young Kim, 2 Hua Xie, 1 , 7 Joydeb Kumar Kundu, 8 Zae Young Ryoo, 2Ann M. Bode, 1 Young-Joon Surh, 3 and Zigang Dong. (PMC)
(2) Ginger Extract: Bioavailability Study and Lung Cancer Preventive Effect by Sang, Shengmin. (NIH)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Scientists may have found a pungent spice which processes the potential to treat lung cancer, according to studies.
Lung cancer is a medical condition characterized by irregular cell growth in the lung tissue.
In Canada, according to the statistics, lung cancer is the leading cause of death in both men and women. Lung cancer accounts for 26.7% of all deaths from cancer and 6.5% of all mortality.
The 5-year survival rate for people with stage IB NSCLC is about 68%.
At the advanced stage, the lung cancer cell may suppress the nearby blood vessels and nerves leading to vomiting blood and localized severe pain accompanied by other general symptoms of cancer such as weight loss, reduced appetite.
In this stage, lung cancer also can travel a distance away to infect other healthy cells of tissue and organs, leading to secondary metastasis.
The most common glands and organs of lung cancer metastases are the adrenal gland, bones, brain, and liver.
Although there are many factors associated with the onset of lung cancer, some researchers suggested that current and past smoking accounts for most of the cases. The risk of developing lung cancer is about 23 times higher in male smokers compared to non-smokers, epidemiologically.
Dr. Ozlü T, the lead scientist in examining the risk of lung cancer from smoking, wrote, "The association between cigarettes and lung cancer has been proven by large cohort studies. Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers. In recent decades, there has been a shift from squamous and small cell lung cancer types to adenocarcinoma, due to increasing rates of smoking among the female population and rising light cigarette usage".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of lung cancer with no side effects compared to chemo medication examined the anti-lung cancer of bioactive compounds isolated from ginger.
[6]-shogaol, [6]-paradol and [6]-gingerol, potentiate the anti-NSCLC activity, however, [6]-shogaol showed the greatest inhibitory effects on the NSCLC cell proliferation and anchorage-independent growth.
[6]-Shogaol also induced cell cycle arrest (G1 or G2/M) and apoptosis as well as the cascades associated with the programming cell deaths.
Furthermore, [6]-shogaol inhibited protein (Akt kinase activity), associated with cancer proliferation and survival In NCI-H1650 lung cancer cells by inhibiting the regulator involved in cell cycle progression.
Dr. Myoung Ok Kim and colleagues in the final report said, "The current study clearly indicates that [6]-shogaol can be exploited for the prevention and/or treatment of NSCLC".
In order to reveal more information about ginger anti-lung cancer activity, researchers examined the [6]-gingerol and [6]-shogaol and a ginger extract with a high level of shogaols (GEHS) against lung cancer cells.
[6]- shogaol has greater growth inhibitory activity (about 10-fold) on lung and colon cancer cell lines than [6]- gingerol.
Shogaols of ginger preparations and GEHS has a stronger cancer-preventive effect, compared to other ginger extracts.
The inhibitory activities of GEHS and extract from fresh ginger, as well as [6]-shogaol and [6]-gingerol inhibited an NNK-induced lung carcinogenesis model in A/J mice.
These results provide the basic information on key active cancer preventive constituents in ginger extracts. The development of a standardized and more active ginger extract preparation will facilitate future pre-clinical and clinical studies on the health benefits of ginger extracts, according to the author.
Taken together, ginger processed with a high amount of bioactive compounds may be considered a function alternative for prevention and combined primary therapy for the treatment of lung cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 by Myoung Ok Kim, 1 , 2 , † Mee-Hyun Lee, 1 , 3 , † Naomi Oi, 1 , † Sung-Hyun Kim, 1 , 2 , †Ki Beom Bae, 1 Zunnan Huang, 1 , 4 Dong Joon Kim, 1 , 5 Kanamata Reddy, 1 Sung-Young Lee,1 , 6 Si Jun Park, 2 Jae Young Kim, 2 Hua Xie, 1 , 7 Joydeb Kumar Kundu, 8 Zae Young Ryoo, 2Ann M. Bode, 1 Young-Joon Surh, 3 and Zigang Dong. (PMC)
(2) Ginger Extract: Bioavailability Study and Lung Cancer Preventive Effect by Sang, Shengmin. (NIH)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
#Cucumber Inhibits the Cytokines Associated with the Onset of Cardiovascular Disease (CVD), Reserachers Suggest
Kyle J. Norton
Cardiovascular disease (CVD) is a class of diseases associated with blockage of blood vessels that heart disease and stroke, depending on the affected location.
Most cases of CVD are caused by reduced oxygen-rich blood inducing heart damage or the death of neurons in the brain.
In other words, if the reduced oxygen-rich blood flow occurs in the heart, it causes heart disease. On the other hand, if the reduced rich oxygen blood occurs in the brain, it causes a stroke.
Most cases of CVD in the Western world is coronary heart disease involved in plaque accumulated on the arterial wall due to an unhealthy diet with high saturated and trans fat and a lifestyle such as smoking accompanied by an overdose of the supplement of calcium.
According to the US statistics, from 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.
Believe it or not, CVD has caused a significant burden in the US healthcare system with the annual total cost at $351.2 billion in 2014-2015, with $213.8 billion in direct cost, including 46% for inpatient care.
Some researchers suggested that the increase of CVD, particularly in coronary heart disease at the alarming rate in the US, is probably associated with the promotion of a high-fat diet over the past few decades, accompanied by a sedentary lifestyle.
Dr. Jane E Freedman wrote, "Over the past two decades, significant progress has been made in the treatment of acute and chronic cardiovascular disease".
"According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease".
Additionally, "Dietary intake of specific nutrients has been suggested as a means of modifying the progression of cardiovascular disease. One such example is the proposed use of foods rich in select vitamins or flavonoids. Epidemiologic studies have reported an inverse relationship between the total dietary intake of plant flavonoids and the incidence of cardiovascular disease".
In other words, if you follow a high-fat diet, you are at substantial risk of diseases associated with obesity, including CVD.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
In finding a natural compound that has a potential effect on endothelium in the onset of cardiovascular diseases(CVD), researchers examined the water/ethanol extract of Cucumis sativus L. (CSE) fruit anti CVD activity.
The study included water/ethanol extract of Cucumis sativus L. (CSE) fruit effect in the attenuation of the damaging effect of pro-inflammatory lipopolysaccharide (LPS) in vitro model of endothelial cells associated with the onset of CVD.
According to the tested assay, administration of CSE reduced LPS-induced cytotoxicity and decreased cellular detachment, restoring the expression of tight junction ZO-1 in the contribution to barrier function.
In protein analysis, Cucumis sativus L. inhibited the early secretion of inflammatory IL-8 and Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory cytokines IL-6 and IL-1α occurred late at 7 and 24 h respectively.
Additionally, in the prevention of the overexpression of pro-inflammatory cytokines, CSE stimulated the secretion of anti-inflammatory IL-10 and increased the production of IL-18 and IFN-γ in the modulation of the immune response.
Furthermore, according to the tested dose differentiation, the angiogenetic activity induced by inflammatory LPS was also prevented by the injection of Cucumis sativus L. extract.
Dr. wrote, at the end of the experiment, " Our results have clearly demonstrated that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells (associated with the risk of CVD)".
Moreover, in vivo, the compounds of Cucumis melo L. protected the impairment of the endothelial barrier associated with the risk of CVD induced by intraperitoneal injection of a high dose of CuEC (2 mg/kg).
In other words, cucurbitacins at a higher dose can induce toxicity to the cells of the endothelium, however, at low doses, CuEC (1 mg/kg) can lead to a decline in systolic blood pressure (SBP) without causing toxicity in mice by suppressing the angiotensin II (Ang II)-induced SBP increase.
Interestingly, the efficacy of CuEC's antihypertensive property was involved in facilitating acetylcholine-mediated vasodilation in the mesenteric arteries of tested mice.
Researchers after taking into account co and con-founders said, " In vitro studies showed that CuEC induced vasodilation in a dose-dependent manner in mesenteric arteries of both mice and rats. Pretreatment with CuEC inhibited phenylephrine-mediated vasoconstriction".
Taken together, cucumber and its bioactive compound cucurbitacin B (CuB) at the lower dose may be used for the treatment of cardiovascular diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao & Hu Xu. (Hypertensive Research)
(3) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (Journal of the American College of Cardiology)
Cardiovascular disease (CVD) is a class of diseases associated with blockage of blood vessels that heart disease and stroke, depending on the affected location.
Most cases of CVD are caused by reduced oxygen-rich blood inducing heart damage or the death of neurons in the brain.
In other words, if the reduced oxygen-rich blood flow occurs in the heart, it causes heart disease. On the other hand, if the reduced rich oxygen blood occurs in the brain, it causes a stroke.
Most cases of CVD in the Western world is coronary heart disease involved in plaque accumulated on the arterial wall due to an unhealthy diet with high saturated and trans fat and a lifestyle such as smoking accompanied by an overdose of the supplement of calcium.
According to the US statistics, from 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.
Believe it or not, CVD has caused a significant burden in the US healthcare system with the annual total cost at $351.2 billion in 2014-2015, with $213.8 billion in direct cost, including 46% for inpatient care.
Some researchers suggested that the increase of CVD, particularly in coronary heart disease at the alarming rate in the US, is probably associated with the promotion of a high-fat diet over the past few decades, accompanied by a sedentary lifestyle.
Dr. Jane E Freedman wrote, "Over the past two decades, significant progress has been made in the treatment of acute and chronic cardiovascular disease".
"According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease".
Additionally, "Dietary intake of specific nutrients has been suggested as a means of modifying the progression of cardiovascular disease. One such example is the proposed use of foods rich in select vitamins or flavonoids. Epidemiologic studies have reported an inverse relationship between the total dietary intake of plant flavonoids and the incidence of cardiovascular disease".
In other words, if you follow a high-fat diet, you are at substantial risk of diseases associated with obesity, including CVD.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
In finding a natural compound that has a potential effect on endothelium in the onset of cardiovascular diseases(CVD), researchers examined the water/ethanol extract of Cucumis sativus L. (CSE) fruit anti CVD activity.
The study included water/ethanol extract of Cucumis sativus L. (CSE) fruit effect in the attenuation of the damaging effect of pro-inflammatory lipopolysaccharide (LPS) in vitro model of endothelial cells associated with the onset of CVD.
According to the tested assay, administration of CSE reduced LPS-induced cytotoxicity and decreased cellular detachment, restoring the expression of tight junction ZO-1 in the contribution to barrier function.
In protein analysis, Cucumis sativus L. inhibited the early secretion of inflammatory IL-8 and Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory cytokines IL-6 and IL-1α occurred late at 7 and 24 h respectively.
Additionally, in the prevention of the overexpression of pro-inflammatory cytokines, CSE stimulated the secretion of anti-inflammatory IL-10 and increased the production of IL-18 and IFN-γ in the modulation of the immune response.
Furthermore, according to the tested dose differentiation, the angiogenetic activity induced by inflammatory LPS was also prevented by the injection of Cucumis sativus L. extract.
Dr. wrote, at the end of the experiment, " Our results have clearly demonstrated that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells (associated with the risk of CVD)".
Moreover, in vivo, the compounds of Cucumis melo L. protected the impairment of the endothelial barrier associated with the risk of CVD induced by intraperitoneal injection of a high dose of CuEC (2 mg/kg).
In other words, cucurbitacins at a higher dose can induce toxicity to the cells of the endothelium, however, at low doses, CuEC (1 mg/kg) can lead to a decline in systolic blood pressure (SBP) without causing toxicity in mice by suppressing the angiotensin II (Ang II)-induced SBP increase.
Interestingly, the efficacy of CuEC's antihypertensive property was involved in facilitating acetylcholine-mediated vasodilation in the mesenteric arteries of tested mice.
Researchers after taking into account co and con-founders said, " In vitro studies showed that CuEC induced vasodilation in a dose-dependent manner in mesenteric arteries of both mice and rats. Pretreatment with CuEC inhibited phenylephrine-mediated vasoconstriction".
Taken together, cucumber and its bioactive compound cucurbitacin B (CuB) at the lower dose may be used for the treatment of cardiovascular diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao & Hu Xu. (Hypertensive Research)
(3) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (Journal of the American College of Cardiology)
#Eggplant Inhibits Enzymes Associated with the Risk the Type 2 #Diabetes, Scientists Show
Kyle J. Norton
Eggplant, the night shape fruit or vegetable may have a strong effect in reducing the risk and treatment of type 2 diabetes, some researchers suggested.
Type 2 diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
According to the US statistics in 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. and 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that the widespread type 2 diabetes in the US was associated with the promotion of the Western diet which has been found to complicate the risk of insulin receptor sites clogged up by fat and cholesterol, affecting the receptor in absorbing and releasing insulin from and to the body.
Dr. Merat S, the lead scientist in the study of a group of mice involved the Western diet risk of insulin resistance and hyperinsulinemia wrote, "The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".and "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis but also IR, potentially complicating the interpretation of results".
These results firmly suggested long-term followers of the Western diet high in saturated and trans fat, red meat, processed foods, and low in fruits and vegetables are the main culprits for the onset of insulin resistance, the early stage of type 2 diabetes.
Therefore, by changing to a healthy diet that reduces the intake of total fat (saturated fatty acids in particular) and increases the intake of dietary fiber by consuming more vegetables and fruits and whole-grain cereal products, diabetes is preventable.
Dr. Matti Uusitupa, MD, in the article "Lifestyles Matter in the Prevention of Type 2 Diabetes" quoted, "In a Swedish uncontrolled study shown that an increase in physical activity and moderate weight loss reduced the incidence of type 2 diabetes by 50% in middle-aged men with IGT" and
"In a Chinese study of IGT patients, 6-year interventions with diet, physical activity, and diet plus physical activity resulted in an approximate 30–40% reduction in diabetes risk in both normal weight and overweight persons".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in the season. While it's generally thought of as a vegetable, eggplant is actually a fruit.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the concerns of the widespread type 2 diabetes among Americans, researchers launched an investigation to examine the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation of an eggplant-based diet as a choice for the management of type 2 diabetes.
The recommendation is based on the rationale is the high fiber and low soluble carbohydrate content of eggplant.
Application of phenolic-enriched extracts of eggplant showed a moderate free radical scavenging-linked antioxidant activity and high alpha-glucosidase inhibition by preventing the glucosidase in breaking down starch and disaccharides to glucose and moderate to high angiotensin I-converting enzyme (ACE) inhibition activity in the prevention of β-cell dysfunction and apoptosis occurring in type 2diabetes.
By inhibiting these enzymes researchers suggested that intake of eggplant should provide a strong biochemical basis for managing type 2 diabetes by controlling glucose absorption.
Dr.Kwon YI, the lead author said, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Further analysis of the phenolic antioxidant in the eggplant, researchers conducted an experiment on the member chlorogenic acids (CGAs) in chronic diseases including diabetes, by searching the database of online medical literature.
* The biological properties of CGA in addition to its antioxidant and anti-inflammatory effects were found in some studies.
* CGA was found to exert pivotal roles in glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
* CGA demonstrated a wide range of potential health benefits, including its anti-diabetic, anti-carcinogenic, anti-inflammatory, and anti-obesity impacts, which may provide a non-pharmacological and non-invasive approach.
Taken together, eggplant processed with a high amount of phenolic compound may be considered a functional vegetable in the prevention of type 2 diabetes and an adjunct therapy combined with primary medicine for the treatment of the disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) in outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ.(PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)
(4) Lifestyles Matter in the Prevention of Type 2 Diabetes by Matti Uusitupa, MD
Eggplant, the night shape fruit or vegetable may have a strong effect in reducing the risk and treatment of type 2 diabetes, some researchers suggested.
Type 2 diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
According to the US statistics in 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. and 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that the widespread type 2 diabetes in the US was associated with the promotion of the Western diet which has been found to complicate the risk of insulin receptor sites clogged up by fat and cholesterol, affecting the receptor in absorbing and releasing insulin from and to the body.
Dr. Merat S, the lead scientist in the study of a group of mice involved the Western diet risk of insulin resistance and hyperinsulinemia wrote, "The Western diet group had higher average glucose levels (187+/-16 versus 159+/-12 mg/dL) and 4.5-fold higher plasma insulin levels".and "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis but also IR, potentially complicating the interpretation of results".
These results firmly suggested long-term followers of the Western diet high in saturated and trans fat, red meat, processed foods, and low in fruits and vegetables are the main culprits for the onset of insulin resistance, the early stage of type 2 diabetes.
Therefore, by changing to a healthy diet that reduces the intake of total fat (saturated fatty acids in particular) and increases the intake of dietary fiber by consuming more vegetables and fruits and whole-grain cereal products, diabetes is preventable.
Dr. Matti Uusitupa, MD, in the article "Lifestyles Matter in the Prevention of Type 2 Diabetes" quoted, "In a Swedish uncontrolled study shown that an increase in physical activity and moderate weight loss reduced the incidence of type 2 diabetes by 50% in middle-aged men with IGT" and
"In a Chinese study of IGT patients, 6-year interventions with diet, physical activity, and diet plus physical activity resulted in an approximate 30–40% reduction in diabetes risk in both normal weight and overweight persons".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in the season. While it's generally thought of as a vegetable, eggplant is actually a fruit.
Chemical constituents
The vegetable chemical compounds containing include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the concerns of the widespread type 2 diabetes among Americans, researchers launched an investigation to examine the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation of an eggplant-based diet as a choice for the management of type 2 diabetes.
The recommendation is based on the rationale is the high fiber and low soluble carbohydrate content of eggplant.
Application of phenolic-enriched extracts of eggplant showed a moderate free radical scavenging-linked antioxidant activity and high alpha-glucosidase inhibition by preventing the glucosidase in breaking down starch and disaccharides to glucose and moderate to high angiotensin I-converting enzyme (ACE) inhibition activity in the prevention of β-cell dysfunction and apoptosis occurring in type 2diabetes.
By inhibiting these enzymes researchers suggested that intake of eggplant should provide a strong biochemical basis for managing type 2 diabetes by controlling glucose absorption.
Dr.Kwon YI, the lead author said, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Further analysis of the phenolic antioxidant in the eggplant, researchers conducted an experiment on the member chlorogenic acids (CGAs) in chronic diseases including diabetes, by searching the database of online medical literature.
* The biological properties of CGA in addition to its antioxidant and anti-inflammatory effects were found in some studies.
* CGA was found to exert pivotal roles in glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
* CGA demonstrated a wide range of potential health benefits, including its anti-diabetic, anti-carcinogenic, anti-inflammatory, and anti-obesity impacts, which may provide a non-pharmacological and non-invasive approach.
Taken together, eggplant processed with a high amount of phenolic compound may be considered a functional vegetable in the prevention of type 2 diabetes and an adjunct therapy combined with primary medicine for the treatment of the disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) in outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ.(PubMed)
(3) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet by Merat S1, Casanada F, Sutphin M, Palinski W, Reaven PD. (PubMed)
(4) Lifestyles Matter in the Prevention of Type 2 Diabetes by Matti Uusitupa, MD
#Fennel Protects the Liver Against Toxicity, According to Studies
Kyle J. Norton
Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection is an action that prevents injury and damage to the liver, regardless of the causes.
Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging, and viral and bacterial infection are associated with the increased risk of liver disease.
Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.
Untreated liver disease or liver disease that is not treated properly over time can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.
Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
These results suggested that a change in diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and nd to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.
Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.
Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats was feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during the make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that
* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in the recurrent HCV hepatitis group is significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.
* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.
Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individuals but significantly higher in liver damage tested rats.
* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.
* Increased levels of Laminin (LN), a protein of the extracellular matrix, is also associated with a substantial risk of the development of liver fibrosis.
* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and is also considered a critical biomarker of carcinogenesis.
The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group
However, application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) and 8 - hydroxy-2-deoxyguanosine (8-OHdG).
Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.
Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.
Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4
Precisely, fennel significantly decreased expression serums of ALT, AST, HA, LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.
Dr. Zhang ZG, the lead author, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevents the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".
The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidant activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shortShorty Awardy award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection is an action that prevents injury and damage to the liver, regardless of the causes.
Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging, and viral and bacterial infection are associated with the increased risk of liver disease.
Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.
Untreated liver disease or liver disease that is not treated properly over time can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.
Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
These results suggested that a change in diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and nd to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.
Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.
Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats was feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during the make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that
* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in the recurrent HCV hepatitis group is significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.
* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.
Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individuals but significantly higher in liver damage tested rats.
* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.
* Increased levels of Laminin (LN), a protein of the extracellular matrix, is also associated with a substantial risk of the development of liver fibrosis.
* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and is also considered a critical biomarker of carcinogenesis.
The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group
However, application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) and 8 - hydroxy-2-deoxyguanosine (8-OHdG).
Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.
Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.
Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4
Precisely, fennel significantly decreased expression serums of ALT, AST, HA, LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.
Dr. Zhang ZG, the lead author, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevents the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".
The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidant activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shortShorty Awardy award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
#Healthyfood #Broccoli Does Not Process a Short Term Benefit in the Inhibition of Asthmatic Symptoms, According to Studies
Kyle J. Norton
Respiratory Disease is a medical condition that affects the breathing organs and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.
The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.
According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.
In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
Besides episodes of wheezing, coughing, chest tightness, and shortness of breath, patients with asthma also experience symptoms of reversible airflow obstruction and bronchospasm.
Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.
Asthma in some cases can interfere with daily activities and may lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episodes and severity of the attacks.
According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.
Believe it or not, African Americans in the U.S. die from asthma at a higher rate than people of other races or ethnicities.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
To find a natural food for the prevention and treatment of respiratory diseases, researchers examined the effect of Broccoli sprouts (BS) on airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen.
A double-blind, placebo-controlled, randomized trial to compare the effects of BS with placebo (alfalfa sprouts [AS]) on airway inflammation and markers of OS included 40 adults (aged 18-50 years) who were randomized to eat either (a) 100 g of BS daily or (b) 100 g of AS daily for 3 days.
According to the tested analysis,
* BS ingestion for 3 consecutive days did not reduce FeNO in asthma, despite causing a marked increase in serum SFN concentrations (21 vs 22 parts per billion, P = .76).
* Furthermore, BS administration did not induce cytoprotective antioxidant genes in either PBMCs or nasal epithelial cells,
* Moreover, BS consumption did not reduce OS and inflammatory markers or improve lung function.
In other words, short-term interference of BS showed no improvement in the symptoms in asthmatic patients
Based on the results, researchers wrote, " Ingestion of the whole BS for 3 days does not appear to improve eosinophilic pulmonary inflammation, inflammatory and OS biomarkers, or clinical features of asthma among atopic adults with asthma despite resulting in a marked increase in serum SFN levels."
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics by Sudini K1, Diette GB2, Breysse PN3, McCormack MC2, Bull D4, Biswal S5, Zhai S4, Brereton N6, Peng RD7, Matsui EC. (PubMed)
Respiratory Disease is a medical condition that affects the breathing organs and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing, etc.
The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove carbon dioxide and other waste gases from the body.
According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.
In 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
Besides episodes of wheezing, coughing, chest tightness, and shortness of breath, patients with asthma also experience symptoms of reversible airflow obstruction and bronchospasm.
Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.
Asthma in some cases can interfere with daily activities and may lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episodes and severity of the attacks.
According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.
Believe it or not, African Americans in the U.S. die from asthma at a higher rate than people of other races or ethnicities.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
To find a natural food for the prevention and treatment of respiratory diseases, researchers examined the effect of Broccoli sprouts (BS) on airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen.
A double-blind, placebo-controlled, randomized trial to compare the effects of BS with placebo (alfalfa sprouts [AS]) on airway inflammation and markers of OS included 40 adults (aged 18-50 years) who were randomized to eat either (a) 100 g of BS daily or (b) 100 g of AS daily for 3 days.
According to the tested analysis,
* BS ingestion for 3 consecutive days did not reduce FeNO in asthma, despite causing a marked increase in serum SFN concentrations (21 vs 22 parts per billion, P = .76).
* Furthermore, BS administration did not induce cytoprotective antioxidant genes in either PBMCs or nasal epithelial cells,
* Moreover, BS consumption did not reduce OS and inflammatory markers or improve lung function.
In other words, short-term interference of BS showed no improvement in the symptoms in asthmatic patients
Based on the results, researchers wrote, " Ingestion of the whole BS for 3 days does not appear to improve eosinophilic pulmonary inflammation, inflammatory and OS biomarkers, or clinical features of asthma among atopic adults with asthma despite resulting in a marked increase in serum SFN levels."
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics by Sudini K1, Diette GB2, Breysse PN3, McCormack MC2, Bull D4, Biswal S5, Zhai S4, Brereton N6, Peng RD7, Matsui EC. (PubMed)
#Ginger Inhibits Enzymes and Stress Markers Associated with the Risk of Type 2 #Diabetes, Scientists Say
Kyle J. Norton
Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not know what causes the pancreas to die off or receptor sites clogged up. However, they do know obesity or overweight, gender, ethnicity, age, family history, and gestation diabetes, are associated with an increased risk of type 2 diabetes.
Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.
The most common symptoms of type 2 diabetes are increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.
If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.
According to statistics, diabetes is one of the most common disease in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million who are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest-growing segments of the diabetes population".
"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".
Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial, included 70 types 2 diabetic patients allocated randomly into the ginger group consumed 1600 mg ginger, and the control group consumed 1600 mg wheat flour daily for 12 weeks.
Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, and insulin resistance.
Furthermore, the blood profile of the treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.
There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between the two groups.
The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduces inflammation in type 2 diabetic patients.
Additionally, with an aim to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.
The double-blind, placebo-controlled, randomized clinical trial included 20-60 -60-year-old patients with type 2 diabetes who did not receive insulin.
Participants in the intervention and control groups received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.
At the end of the 3 months, researchers showed that all parameters associated with diabetes were reduced substantially in the treatment group compared to control.
More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.
Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.
Dr. Shidfar F, the lead scientist said, "The 3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes".
Taken together, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)
Ginger may be next generation whole food used for the prevention and treatment of type 2 diabetes, with no side effects, some scientists suggested.
Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose due to either cell in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
Researchers do not know what causes the pancreas to die off or receptor sites clogged up. However, they do know obesity or overweight, gender, ethnicity, age, family history, and gestation diabetes, are associated with an increased risk of type 2 diabetes.
Some researchers also suggested that people with certain medical conditions such as polycystic ovary syndrome. and high blood pressure is more prone to the onset of the disease.
The most common symptoms of type 2 diabetes are increased thirst that won't stop with water intake, increased hunger (especially after eating), dry mouth, frequent urination, and unintentional weight loss.
If you experience some of the symptoms above, please make you check with your doctor to rule out the possibility of diabetes.
According to statistics, diabetes is one of the most common disease in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million who are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
Dr. Rita R. Kalyani in the study to examine the increase with age and risk of type 2 diabetes wrote, "The unprecedented aging of the world's population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest-growing segments of the diabetes population".
"Almost one-third of U.S. adults over the age of 65 years have diabetes. Approximately half of those are undiagnosed, and an additional one-third of older adults have prediabetes" and "management of older adults with diabetes is clearly more complicated given the observation that they commonly have multiple coexisting medical conditions that can impact clinical management".
Compared to the general population risk of type 2 diabetes, the results clearly stated, the risk of type diabetes in elderly is 3 fold higher and the management of the disease is more difficult due accompanied by other medical conditions, such as high blood pressure and cholesterol
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural whole food for the prevention and treatment of diabetes with little or no side effects, researchers looked into the effects of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus.
The double-blinded, placebo-controlled clinical trial, included 70 types 2 diabetic patients allocated randomly into the ginger group consumed 1600 mg ginger, and the control group consumed 1600 mg wheat flour daily for 12 weeks.
Patients treated with ginger demonstrated a significant effect in reducing the levels of fasting plasma glucose, 3 months average glucose concentration, and insulin resistance.
Furthermore, the blood profile of the treatment group also displayed lower levels of triglyceride, total cholesterol, a hormone associated with lipid peroxidation. compared to the placebo group.
There were no significant differences in high-density lipoprotein (HDL), low-density lipoprotein LDL, and TNFα, the inflammatory cytokine between the two groups.
The findings firmly indicated ginger improves insulin sensitivity and some fractions of lipid profiles and reduces inflammation in type 2 diabetic patients.
Additionally, with an aim to reaffirm the effects of ginger against the development of type 2 diabetes and diabetic complications, researchers investigated the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes.
The double-blind, placebo-controlled, randomized clinical trial included 20-60 -60-year-old patients with type 2 diabetes who did not receive insulin.
Participants in the intervention and control groups received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months.
At the end of the 3 months, researchers showed that all parameters associated with diabetes were reduced substantially in the treatment group compared to control.
More precisely, the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41 ± 18.83 vs. 1.63 ± 4.28 mg/dL, p < 0.001), (Hemoglobin A1C)HbA1c percentage (-0.77 ± 0.88 vs. 0.02 ± 0.16%, p < 0.001), insulin (-1.46 ± 1.7 vs. 0.09 ± 0.34 μIU/mL, p < 0.001), insulin resistance (-16.38 ± 19.2 vs. 0.68 ± 2.7, p < 0.001), high-sensitive CRP (-2.78 ± 4.07 vs. 0.2 ± 0.77 mg/L, p < 0.001), paraoxonase-1 (PON-1) (22.04 ± 24.53 vs. 1.71 ± 2.72 U/L, p < 0.006), total antioxidant capacity (TAC) (0.78 ± 0.71 vs. -0.04 ± 0.29 µIU/mL, p < 0.01) and MDA (-0.85 ± 1.08 vs. 0.06 ± 0.08 µmol/L, p < 0.001) were significantly different.
Where paraoxonase ((PON)-1 is an enzyme associated with the protection against lipid oxidation, Malondialdehyde (MDA) is an oxidative stress marker.
Dr. Shidfar F, the lead scientist said, "The 3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes".
Taken together, ginger may be considered a functional food for the prevention and combined with the primary therapy for the treatment of type 2 diabetes with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(2) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients by Mahluji S1, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. (PubMed)
(3) The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes by Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. (PubMed)
(4) Diabetes and Aging: Unique Considerations and Goals of Care, Rita R. Kalyani, Sherita H. Golden and William T. Cefalu. (Diabetes Care)
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