#Herbal #Coltsfoot Protects the Bone Marrow Cells Against the Side Effects of Polychemotherapy-Induced Apoptosis, Researchers Find

Kyle J. Norton

Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone. including the spine, pelvis, underarm, and leg. etc.

Acute leukemia is a condition caused by a rapid increase in the number of extremely immature white blood cells that appear in the bloodstream in the other parts of the body, including tissue and organs, Acute leukemia can also be classified into
* Acute lymphoblastic leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a type of cancer of the abnormal growth of extremely immature lymphocytes overproduced by the bone marrow and/or lymphatic system. The condition has a tendency to multiply quickly, leading to the death of normal white blood cells in the bone marrow and/or lymphatic system.

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common child form of leukemia with about 80% of all cases.

* Acute myeloid leukemia (AML)
Acute myelogenous leukemia (AML) is a cancer of the myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.

According to the statistics proved by the American Cancer Society, in 2019, approximately 21,450 new cases of acute myeloid leukemia (AML) will be diagnosed in adults. The disease also causes the
of 10,920 deaths of American adults.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of bone marrow cell integrity, researchers examined the protective effect of polysaccharides from Tussilago farfara L. on bone marrow cells.

According to the tested analysis, Tussilago farfara L. protected the bone marrow cells against the side effects of polychemotherapy-induced apoptosis.

Furthermore, polychemotherapy-induced DNA damage in bone marrow cells was also reversed by the application of polysaccharides from Tussilago farfara L.

In vivo, in the small intestinal epithelium of C57Bl/6 mice, polysaccharides from Tussilago farfara L. also induced renoprotective properties against the chemo side effects.


Taken together, coltsfoot may be considered a remedy for the protection of bone marrow cell integrity against the onset of leukemia, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay by Safonova EA1, Lopatina KA2, Vychuzhanina AV2, Mashanova VA2, Razina TG2, Borovskaya TG2, Zueva EP2, Gur'ev AM3, Belousov MV. (PubMed)

#Sulforaphane Derived From #Isothiocyanates Exerts a Strong Neuroprotection by Enhancing the Antioxidant in Improving Neuronal Survival

Kyle J. Norton

Dithiolthiones, the bioactive compound found abundantly in the cruciferous vegetables may have a potential effect on reducing the risk of neurodegenerative disease, some scientists found.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Neurodegenerative disease is a group of conditions that primarily affect the neurons in the brain, including Parkinson's disease (PD) and Alzheimer's disease.

In other words, neurodegenerative disease is caused by the progressive death of neurons in different regions of the nervous system.


The progressive loss of neurons induced neurological and neuropsychological signs and symptoms have also been found in comparison to the stage of disease onset of patients.

The causes of neurodegenerative diseases are unknown, however, researchers do know that the increase in age is one most consistent risk factor for developing a neurodegenerative disease, especially AD or PD, as the disease has been found over 60% in the population aged 65 and beyond compared to another group.

And this number is found to increase at an alarming rate. Dr. Serge Przedborski, the lead author in the investigation of the risk of neurodegenerative disease in elderly said, "it can be anticipated that, over the next generations, the proportion of elderly citizens will double, and, with this, possibly the proportion of persons suffering from some kind of neurodegenerative disorder".

Epidemiologically, geographically, hereditary viral, and toxicological exposure correlates, and deficiencies of elements such as calcium and selenium are some of the risk factors in the development of neurological diseases.


Also, people who follow the Western diet pattern are at an increased risk of the disease. According to the 2018 Alzheimer's Association International Conference, July 22-26, 2018 in Chicago, Illinois, the Western diet is known to include high consumption of red meats, processed meats, as well as fatty and fried foods. This dietary pattern has been linked to a greater risk of cognitive decline and dementia.

As the autopsied participants' brains followed the Western diet showed a significant change in neuropathologies such as β-amyloid plaques, tau tangle density, neocortical Lewy bodies, and cerebral atherosclerosis, among others.

This analysis may indicate that by changing to a healthy diet with a high in fruits and vegetables and whole grains and less in saturated and trans fat, red meat, and processed foods, the risk of neurodegenerative disease can be reduced substantially.

Researchers on the finding of a natural ingredient or whole food investigated the epidemiologically suggested that sulforaphane, an organosulfur compound present in cruciferous vegetables processed neuroprotective effects in experimental in vitro and in vivo models of neurodegeneration. Using the Morris water maze researchers tested the sulforaphane effects on scopolamine-induced memory impairment in mice.

Sulforaphane (10 or 50mg/kg) was administered to C57BL/6 mice by oral gavage for 14 days (days 1-14), Memory impairment was induced by intraperitoneal injection of scopolamine (1mg/kg) for 7 days (days 8-14).

Mice receiving an injection of scopolamine showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex. The results were observed by a decreased acetylcholine (ACh) level and increased acetylcholinesterase (AChE) activity.

Where acetylcholine (ACh) is a neurotransmitter, associated with the function in sending signals to other cells [neurons, muscle cells, and gland cells] and acetylcholinesterase (AChE) is an enzyme that catalyzes the breakdown of acetylcholine.

Treatment of sulforaphane significantly attenuated the scopolamine-induced memory impairment and improved cholinergic system reactivity.

In other words, sulforaphane exerted a neuroprotective effect against the scopolamine in the induction of oxidative stress to the neurons. Sulforaphane at doses of 10 or 20μM increased the ACh level, decreased the AChE activity, and increased ChAT expression in scopolamine-treated primary cortical neurons.

Dr. Lee S, the lead scientist suggests "Sulforaphane might exert a significant neuroprotective effect on the cholinergic deficit and cognitive impairment".

Additionally, in the concern of no drug treatment of schematic/traumatic brain injury, Alzheimer's disease, and Parkinson's disease which share common characteristics such as oxidative stress, misfolded proteins, excitotoxicity, inflammation, and neuronal loss, researchers investigated the effect of sulforaphane against the mentioned diseases.

In several in vitro and in vivo studies isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, has demonstrated neuroprotective effects.

The efficacy was attributed to the activity of sulforaphane in activating the Nrf2/ARE pathway in modulating the expression of oxidative stress.

Dr. Tarozzi A, the lead author in the final report of the experiment wrote, " sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing neurodegeneration".

More importantly, in dopaminergic neurotoxicity in mice induced by 6-hydroxydopamine (6-OHDA), the phytochemical showed a neuroprotective effect through its ability to enhance the antioxidant enzymes of the host and improve neuronal survival.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane alleviates scopolamine-induced memory impairment in mice by Lee S1, Kim J1, Seo SG2, Choi BR3, Han JS3, Lee KW4, Kim J5. (PubMed)
(2) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases byTarozzi A1, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P.(PubMed)
(3) Neuroprotective effect of sulforaphane in a 6-hydroxydopamine-lesioned mouse model of Parkinson's disease byMorroni F1, Tarozzi A, Sita G, Bolondi C, Zolezzi Moraga JM, Cantelli-Forti G, Hrelia P.(PubMed)
(4) Series Introduction: Neurodegeneration: What is it and where are we?by Serge Przedborski,1,2,3 Miquel Vila,1 and Vernice Jackson-Lewis. (PMC)

#Cranberry Improves Overall Neuro-Psychologic Symptoms and Enhances Short-Term Memory in Patients with #Dementia, Researchers Suggest

Kyle J. Norton

Neuropsychological assessment provides both general and specific information about current levels of cognitive performance. An average or composite score across multiple ability areas provides an overall index of how well a person functions cognitively at the current time.

Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision-making.

Cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding, or memory. The cognitive deficit can be acute or chronic.

Acute cognitive deficit is a short-term health problem caused by drug toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction, or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.

Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of neurons, leading to problems with language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.

There is no single cause of the chronic cognitive deficit. An increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, obesity and lack of exercise are some prevalent factors found in patients with chronic cognitive deficits.

Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).

Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.

According to the observation of the patient's MRI, the patient's brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles), and reduced use of glucose, the sugar that's the primary source of energy for cells.

Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors for cognitive impairment in the Western world.

Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of the neurological disorder, researchers examined the cranberry extract (CE) neuropsychologic effect.

The double-blind, placebo-controlled, randomized, parallel-group, clinical trial included 50 community-dwelling, cognitively intact volunteers, > or = 60 years old, who reported no history of dementia or significant neurocognitive impairments.

Participants in the study were randomly assigned to receive either 32 ounces/day of a beverage containing 27% cranberry juice per volume (n = 25) or placebo (n = 25) for 6 weeks.

According to the neuropsychologic tests before and after treatment on participants' self-reported, there was a nonsignificant trend (X2(1) = 2.373, p = 0.123) on overall abilities to remember.

However, more than twice of many participants (37.5%) reported the overall ability to remember at the end of treatment compared to placebo controls (17.4%).

In other words, cranberry extract (CE) although can not improve overall neuropsychologic symptoms, enhances the short-term memory of dementia or significant neurocognitive impairments.

Taken together, cranberry may be considered a remedy for the improvement of memory, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A double-blinded, placebo-controlled, randomized trial of the neuropsychologic efficacy of cranberry juice in a sample of cognitively intact older adults: pilot study findings by Crews WD Jr1, Harrison DW, Griffin ML, Addison K, Yount AM, Giovenco MA, Hazell J. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)

#Antioxidant #Indicaxanthin Exerts Protective Effects Against Atherogenesis Toxicity, According to Studies

Kyle J. Norton

An atheroma, or atheromatous plaque ("plaque"), is an abnormal accumulation of plaque in the inner layer of the wall of an artery, found in most adults, a leading cause of atherosclerosis.

Atherosclerosis is a condition caused by long-term plaques built up on the wall of the arteries, leading to narrowing the arteries, a major cause of the cardiovascular disease (CVD)

CVD is a medical condition involved in blood vessels. CVD can be heart disease or stroke depending on the location of a blood clot which causes blockage of the blood flow in the artery.

According to the statistics provided by the Europeanean Hear Network, cardiovascular disease (CVD) causes 3.9 million deaths in Europe and over 1.8 million deaths in the European Union (EU) every year. In 2015, approximately, 11.3 million new cases of CVD in Europe and 6.1 million new cases of CVD in the EU were diagnosed.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.


Atheromatous plaques build up in the arteries can be classified into several stages, including
* Stage 1 is the foam cells of macrophage and fatty deposits are localized on blood vessel walls.

* Stage 2 Type II is various thread-like fibers or filaments accumulated on the arterial wall.

* Stage 3 is connective tissue deposition on the arteries is thicker.

Stage 1-3 is most frequently found in patients with hypertension, diabetes mellitus, hypercholesterolemia, and who smoke.


* The stages 4 and 5 Type IV and V are conditions in the softer plaque with a thinner fibrous cap containing macrophages and smooth muscle cells are formed.


Atherosclerosis at the early stage is asymptomatic. However, in stage 4 and 5, patients may experience symptoms of chest pain, pain in your leg, arm, particularly in the area of a blocked artery, shortness of breath, fatigue muscle weakness due to reduced blood flow in the artery.


Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains found abundantly in beets, chard, etc.

In finding a potent compound for the treatment of atheromas, 7-Ketocholesterol (7-KC)-induced apoptosis of macrophages is considered a key event in the development of human atheromas.

In human atheromatous plaque-induced by the 7-Ketocholesterol (7-KC), researchers found that* The induction of atheromatous plaque within 24 h of injection of 7-KC was associated with the induced cytotoxicity by elevating the expression of intracellular reactive oxygen species over basal levels.

* Furthermore, levels of preceding NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺ associated with an imbalanced ratio of free radicals and antioxidants were also induced by the administration of 7-KC.

* Moreover, the progressive depletion of total thiols that cause oxidative stress was also promoted by the 7-KC

* Additionally, the redox-sensitive NF-κB involved in the inhibition of oxidation was also de-promoted by 7-KC activation.

* Co-incubation of 2·5 μm of Ind not only completely prevented 7-KC-induced pro-apoptosis in the tested cells but also decreased the parameters that lead to the risk of atheromas.

Based on the findings, researchers said, " Indicaxanthin( a highly bioavailable dietary phytochemical, may exert protective effects against atherogenesis toxicity of 7-KC at a concentration of nutritional interest".

Taken together, indicaxanthin may be considered a remedy for the prevention and treatment of atheromas, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)

#Carotenoids Inhibit the Risk of High Grade #ProstateCancer, According to Studies

Kyle J. Norton

The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.
Prostate cancer is a medical and chronic condition caused by cell growth irregularly in the prostate gland. Most cases of prostate cancer are slow-growing and enlarged prostate and prostate cancer may be detected during Physical (rectum) exams.

Most cases of prostate cancer begin in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper layers to induce colonization.

At the advanced stage, the prostate cancer cells can spread to the distant parts of the body, leading to secondary metastasis.


Prostate cancer can be diagnosed by* Blood tests
* Digital Rectal Examination (DRE)
In DRE, your doctor inserts a lubricated, gloved finger into the rectum to feel the surface of the prostate gland to check for any abnormality of the prostate.

* Transrectal Ultrasound (TRUS)
Ultrasound allows your doctor to visualize and assess the size of your prostate and to check for any abnormality and surrounding area with an image taken from the test. In transrectal ultrasound, a probe is inserted into the rectum to emit ultrasonic impulses against the prostate.

* Prostate-specific antigen (PSA) test
The test is to measure the levels of prostate-specific antigen (PSA), a protein produced by the prostate. The high levels of PSA may be an indication of a higher risk of the presence of prostate cancer.

* Prostatic Acid Phosphatase (PAP) test
Prostatic acid phosphatase (PAP) is a test to measure the level of prostatic acid phosphatase, an enzyme produced by the prostate. The higher the levels of PAP is an indication of the disease progression.

* Prostate biopsy
In a prostate biopsy, samples of the prostate are taken by a thin, tube-like instrument to examine under microscopy to review the stage of cancer.

According to the statistics, prostate cancer is the most common cancer among men particularly older than 65, after skin cancer. in 2019, approximately 174,650 men in the US will be diagnosed with prostate cancer.

The average age of diagnosis is 66.

Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

In finding a potential compound for the prevention and treatment of prostate cancer, researchers examined the effect of carotenoid levels on the risk of high-grade prostate cancer.

The study included the measurement of plasma levels of carotenoids and genotyped 20 single nucleotide polymorphisms (SNP) in SOD1, SOD2, SOD3, XRCC1, and OGG1 in 559 men with non-metastatic prostate cancer undergoing radical prostatectomy.
According to the results from tested assays, the serum of circulated carotenoid levels was inversely associated with the risk of high-grade prostate cancer, with odds ratios (OR) of 0.34 compared to the highest versus lowest quartiles.

In chemical analysis, the relative odds ratio of α-carotene,β-carotene, lycopene, and total carotenoids.was 0.31, .55, 34, and 0.37 respectively.

In other words, all major phytochemicals found in carotenoid work synergistically to enhance the efficacy of carotenoid against the risk of high-grade prostate cancer.


Furthermore, the presence of the SNPs rs25489 in XRCC1, rs699473 in SOD3 and rs1052133 in OGG1 genotypes also was found to modify the activity of α-carotene, β-carotene, and lycopene, respectively.

Believe it or not, the high serum of lycopene was found among men with Gleason score ≤ 3 + 4 and lower FGA (P = 0.04).


More precisely, the efficacy of carotenoids reduced the risk of prostate cancer, however, the risk of high-grade invasive prostate cancer are depending on the levels of lycopene.

Dr. Nordström T, the lead scientist said, "Higher lycopene level was associated with less genomic instability among men with the low-grade disease which is novel and supports the hypothesis that lycopene may inhibit the progression of prostate cancer early in its natural history".

Taken together, carotenoids may be considered a remedy for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer by Nordström T1,2,3, Van Blarigan EL1,2, Ngo V1, Roy R4, Weinberg V5, Song X6, Simko J1,7, Carroll PR1, Chan JM1,2, Paris PL. (PubMed)
(2) Anticancer properties of carotenoids in prostate cancer. A review by Soares Nda C1, Teodoro AJ2, Lotsch PF3, Granjeiro JM3, Borojevic R. (PubMed)
(3) Prostate Cancer by Kyle J, Norton

#Phytochemical #DiallylSulfide (DAS) Inhibits the Proliferation of #Osteosarcoma, Researchers Suggest

Kyle J. Norton

Phytochemical allicin isolated from garlic may be used for the prevention and treatment of osteosarcoma with no side effects, some scientists suggested.

Osteosarcoma is a bone cancer found mostly in teenagers and people over age 60.

Most cases of osteosarcoma are associated with genetic syndromes. In other words, the disease is the result of the conditions associated with inherited mutated genes from the parent.

However, an unhealthy lifestyle such as body weight, physical activity, diet, tobacco, gender, age, height, ethnicity, and exposure to bone radiation also play a major role in many adult cancers.

According to the statistics, in the US, osteosarcoma is rare and approximately 900 new cases of osteosarcoma are reported each year. and children and teens younger than 20 account for half of the numbers.

Dr. James J. Morrow, the lead scientist in the study of the genetic risk of osteosarcoma wrote, "Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life"

And, " Increased risk of osteosarcoma is associated with a number of well-defined genetic syndromes: hereditary retinoblastoma (germline mutation of the Rb gene), Li-Fraumeni syndrome (germline mutation of the p53 gene), Bloom syndrome (germline mutation of the RECQL2 gene), Werner syndrome (germline mutation of the RECQL3 gene), and Rothmund-Thomson syndrome (germline mutation of the RECQL4 gene)"


These results strongly suggested that young teenagers with genetic syndrome are more likely to be infected by the disease, compared to others.

Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

With an aim to find a natural ingredient for the treatment of osteosarcoma with no side effects, researchers at the Wenling City Chinese Medicine Hospital looked into the anti-osteosarcoma activity of the main biologically active compound derived from garlic.


The combined treatment significantly suppressed the invasion, motility, and colony formation ability and activated the protein associated with a pro-apoptotic activity, compared to the lone treatment group.

Furthermore, in vivo. artesunate and allicin also inhibited tumor growth and cell proliferation

Dr.Jiang W, the lead scientist said, "Artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis".

Moreover, in examining the effects of diallyl sulfide (DAS) derived from allicin in vitro and in vivo on the proliferation of human osteosarcoma MG-63 cells, researchers found that in vivo, the nude mice MG-63 cells tumor-bearing model after twenty-one days of treatment with DAS inhibit proliferation of MG-63 cells in a time- and concentration-dependent manner.

DSA groups (different concentrations) showed significantly reduced expression levels of VEGF mRNA, associated with stimulating the formation of blood vessels. compared with those in the control group.

At the dose of 20 and 40 μg/mL, cell migration was significantly lower in the DAS groups (91.4±8.3 and 81.8±7.4, respectively) compared to the control group (150.4±14.7, both).

Also at the dose of 20 and 40 μg/mL, DAS also decreased the microvessel density (MVD) of MG-63 tumor-bearing tissue.

Taken together, phytochemical allicin may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of osteosarcoma.

However, intake of allicin as a form of supplement should be taken with extreme care to prevent overdose toxicity

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo by Jiang W, Huang Y, Wang JP, Yu XY, Zhang LY.(PubMed)
(2) Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells by Hu Y, Chen L, Yi C, Yang F, Chen J.(PubMed)(3) Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies by James J. Morrowa and Chand Khannab. (PMC)

#Herbal #Ashwagandha Inhibits Proteins Associated with the Risk of #PancreaticCancer, Researchers Say

Kyle J. Norton

Cancer is a class of diseases in which a group of cells grow and multiply in disordered and uncontrollable ways in our body, due to the change of cellular DNA. Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ.

However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessels, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.

Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

Pancreatic cancer is a medical and chronic condition characterized by irregular cell growth in the tissue of the pancreas.

In the early stage, pancreatic cancer starts in the cells on the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissues and organs.

The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.

Some researchers suggested long-term use of tobacco, being overweight and obese, exposure to workplace chemicals, age, gender, and family history are some prevalent risk factors for pancreatic cancer.

According to the statistics, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men. Pancreatic cancer accounts for 7% of all cancer deaths.

The 5 years survival rate at stages 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.


Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the treatment of cancer, researchers examined the withaferin-A (WA), the biologically active withanolide extracted from Withania somnifera in human pancreatic cancer cells.

According to the tested analysis, the extract significantly increased the cells' spherical structure with double-layer membranes degraded by autophagy through cleaning out damaged cells in normal cells.

However, in human pancreatic cancer (PC) cells, withanolide extract also blocked the degradation of autophagy by inhibiting SNARE protein in the the-mediated fusion of autophagosomes and lysosomes which contains degradative enzymes enclosed in a membrane.

In other words, in human pancreatic cancer (PC) cells, the extract promotes the cancer cell degradation by autophagy to induce apoptosis.

More precisely, WA induced ER stress-mediated apoptosis. by promoting the accumulation of ubiquitinated proteins, associated with degradation via the proteasome, a protein involved in degrading unneeded or damaged proteins.

In vivo, combining WA with a series of ER stress aggravators enhanced apoptosis synergistically in tumor growth in PC xenografts.

Based on the findings, researchers said, "simultaneous suppression of 2 key intracellular protein degradation systems rendered PC cells vulnerable to ER stress, which may represent an avenue for new therapeutic combinations for this disease".

Taken together, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of pancreatic cancer, pending the result of larger sample size and multicenter study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells by Li X1, Zhu F1, Jiang J2, Sun C3, Zhong Q4, Shen M1, Wang X1, Tian R1, Shi C1, Xu M1, Peng F1, Guo X1, Hu J5, Ye D6, Wang M1, Qin R. (PubMed)