Kyle J. Norton
The lung formed part of the respiratory system is a vital organ located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting it to the bloodstream and exhaling carbon dioxide from the bloodstream.
Lung diseases are a class of conditions associated with reduced function of the lung, including lung cancer.
Lung cancer is a medical condition associated with abnormal growth of the cells in the lung's tissue that begins in the cells on the surface of the inner lining tissues of the lung due to the alternation of cell DNA.
The most common form of primary lung cancer is derived from epithelial cells.
In the US, lung cancer is the leading cause of cancer deaths. According to the statistics from the American Cancer Society, in 2019, about 228,150 new cases of lung cancer, including 116,440 in men and 111,710 in women will be diagnosed in the US.
Sadly, lung cancer also caused the death of 142,670 Americans death, including 76,650 in men and 66,020 in women in the same year.
The lifetime risk of lung cancer in a man is 6.7% compared to 5.9% in a woman.
The exact causes of lung cancer are not known. However, epidemiologically, smoking tobacco, second-hand smoke, radon, asbestos, occupational exposure to certain chemicals, personal or family history of lung cancer and lung disease and exposure to radiation are some major factors found in patients with lung cancer.
Dr. Ozlü T, the lead scientist wrote, " Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".
And, "The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers. Environmental cigarette smoke exposure and different types of smoking have been shown to cause pulmonary carcinoma. DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the protection of lung cell integrity, researchers examined the effect of the efficacy of proanthocyanidin-rich cranberry fraction (PAC) on lung cancer.
According to the tested analysis, NCI-H460 human lung cancer cells treated with 50 µg/mL PAC or vehicle for 6 hours, PAC exerted a significant activity in the regulation of apoptosis, regulation of programmed cell death, positive regulation of cell death, positive regulation of apoptosis, and apoptotic mitochondrial changes.
Moreover, NCI-H460 human lung cancer cells treated with 50 µg/mL PAC showed a strong effect on cancer cell metabolism, protein modifications, and cell cycle by inhibiting the M phase of the mitotic cell cycle, mitosis, M phase, cell cycle checkpoint, and regulation of cell cycle process.
More precisely, PAC-induced lung cancer cell apoptosis and anti-proliferative activity through cell cycle arrest.
Furthermore, PAC treatment also enhanced the levels of glutathione S-transferases associated
with blocking cancer cell metastasis.
PAC treatment also down-regulated DNA metabolism, cell cycle, meiosis, mitosis and interestingly oncogenesis signaling.
PAC treatment also inhibited the alternation of ErbB receptors and signaling pathways and mTOR signaling pathways mutated in lung tumors, involved in cancer development and progression
Taken together, cranberry used in conjunction with other remedies may be considered a remedy for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis by Kresty LA1, Howell AB, Baird M. (PubMed)
(2) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)
Saturday, 7 October 2023
#Betanin Inhibits Oxidative DNA Damage Associated with the Risk of Inflammatory Bowel Disease, According to Studies
Kyle J. Norton
Colon cancer is a medical and chronic condition caused by the irregular growth of cells in the colon, due to the alternation of cell DNA.
Colon-formed part of the digestive tract, including the large intestine with the function to reabsorb fluid before passing them back to the blood and remove waste through the anus.
Colon cancer is one most slow cancers compared to other cancers. In some patients, colon cancer may exist in the colon more than 20 years before it is discovered.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 101,420 new cases of colon cancer will be diagnosed. Colon cancer also causes the death of 51,020 deaths. during 2019.
The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Out of many risk factors involved in the onset of colorectal cancer, aging is one of the major culprits, according to epidemiological studies.
The median age diagnosed with colon cancer is 68 in men and 72 in women compared to the age of 63 of rectal cancer in both men and women.
However, over the past few decades, the incidence of colon cancer has been found to rise in the younger age groups, probably due to the promotion of a high-fat diet.
Dr. Robb Bird, the editor at worldwide health wrote, "Poor diet is associated with about 80 percent of colorectal cancer cases. Even 20 years ago studies were attributing colon cancers to high-fat diets. Colorectal cancer is the third most common cancer in the United States with more than 130,000 cases reported every year. These cancers are a result of a combination of several causes including genetic, epigenetic and environmental causes, such as diet. Hopefully, with more research, the exact pathways by which diet leads to cancer can be discovered. Once discovered, blocking these pathways can hopefully reduce the negative impact of a high-fat diet on colon cancer risk".
Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of continuing colonic inflammation, an important risk factor in the development of colorectal cancer, researchers examined phytochemical compound betanin isolated from beetroot (Beta vulgaris var. rubra) effects against colon cancer.
In patients with inflammatory bowel disease, such as ulcerative colitis (UC) and Crohn's disease (CD), administration of betanin exerted an inhibition against the oxidative DNA damage and induced apoptosis in neutrophils from the blood, compared to those obtained in colon carcinoma-derived Caco-2 cells.
In IBD patients' neutrophils, betanin treatment at the concentration of 100 μM for 24 h modulated the immune function by exerting anti-inflammatory activity, assessed by comet assay.
In Caco-2 cells, injection of H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.
Betanin also exhibited the protein associated with pro-apoptotic function accompanied by the loss of mitochondrial transmembrane potential in the energy transformation.
In other words, betanin promotes the ROS cytotoxicity that leads to colon cancer cell death without harming the nearby cells through its antioxidant activity.
The findings strongly suggested betanin exerts anti-inflammatory and potentially cancer-preventive activity.
Taken together, betanin isolated from beetroot may be considered a supplement for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High-fat diet found to stimulate cell growth in the colon, increasing the risk of colon cancer by the World Health Net
Colon cancer is a medical and chronic condition caused by the irregular growth of cells in the colon, due to the alternation of cell DNA.
Colon-formed part of the digestive tract, including the large intestine with the function to reabsorb fluid before passing them back to the blood and remove waste through the anus.
Colon cancer is one most slow cancers compared to other cancers. In some patients, colon cancer may exist in the colon more than 20 years before it is discovered.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 101,420 new cases of colon cancer will be diagnosed. Colon cancer also causes the death of 51,020 deaths. during 2019.
The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Out of many risk factors involved in the onset of colorectal cancer, aging is one of the major culprits, according to epidemiological studies.
The median age diagnosed with colon cancer is 68 in men and 72 in women compared to the age of 63 of rectal cancer in both men and women.
However, over the past few decades, the incidence of colon cancer has been found to rise in the younger age groups, probably due to the promotion of a high-fat diet.
Dr. Robb Bird, the editor at worldwide health wrote, "Poor diet is associated with about 80 percent of colorectal cancer cases. Even 20 years ago studies were attributing colon cancers to high-fat diets. Colorectal cancer is the third most common cancer in the United States with more than 130,000 cases reported every year. These cancers are a result of a combination of several causes including genetic, epigenetic and environmental causes, such as diet. Hopefully, with more research, the exact pathways by which diet leads to cancer can be discovered. Once discovered, blocking these pathways can hopefully reduce the negative impact of a high-fat diet on colon cancer risk".
Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of continuing colonic inflammation, an important risk factor in the development of colorectal cancer, researchers examined phytochemical compound betanin isolated from beetroot (Beta vulgaris var. rubra) effects against colon cancer.
In patients with inflammatory bowel disease, such as ulcerative colitis (UC) and Crohn's disease (CD), administration of betanin exerted an inhibition against the oxidative DNA damage and induced apoptosis in neutrophils from the blood, compared to those obtained in colon carcinoma-derived Caco-2 cells.
In IBD patients' neutrophils, betanin treatment at the concentration of 100 μM for 24 h modulated the immune function by exerting anti-inflammatory activity, assessed by comet assay.
In Caco-2 cells, injection of H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.
Betanin also exhibited the protein associated with pro-apoptotic function accompanied by the loss of mitochondrial transmembrane potential in the energy transformation.
In other words, betanin promotes the ROS cytotoxicity that leads to colon cancer cell death without harming the nearby cells through its antioxidant activity.
The findings strongly suggested betanin exerts anti-inflammatory and potentially cancer-preventive activity.
Taken together, betanin isolated from beetroot may be considered a supplement for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High-fat diet found to stimulate cell growth in the colon, increasing the risk of colon cancer by the World Health Net
#Healthyfood #CruciferousVegetables' #Sulforaphane Inhibits the Onset and Progression of Neurological Disorders, According to Studies
Kyle J. Norton
Neurological disorders are medical conditions characterized by any disorder of the nervous system caused by structural, biochemical, or electrical abnormalities.
There are many forms of neurological disorders. The most common types of the disease are neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease, epilepsy. multiple sclerosis and Migraines.
Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, nutrition-related disease, environment, and physical injuries have been found to be some major prevalent factors that induce the onset of neurological abnormalities.
According to the Medical Press, globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy, etc) has increased substantially over the past 25 years. These may be the results of over 25 years of economic expansion that have increased the living standard of millions of people in the Southeast Asian region.
The WHO in the evaluation of neurological disorder wrote, "Neurological disorders contribute to 92 million disability-adjusted life years (DALYs) in 2005 projected to increase to 103 million in 2030 (approximately a 12% increase). While Alzheimer's and other dementias are projected to show a 66% increase from 2005 to 2030".
Where one DALY represents the loss of the equivalent of one year of full health.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease Alzheimer's disease, and stroke.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for the protection of brain functioning, researchers examined the effects of cruciferous vegetables are a key part of the arsenal of nutrition-based approaches for reducing the risks of neurological disorders.
According to the search of related articles, in animal model systems, cruciferous vegetables exerted protective activity against neurodegenerative disorders like Alzheimer's and Parkinson's diseases.
In chemical analysis, the efficacy of crucifers in the inhibition of the onset and progression of neurological disorders was attributed to its most abundant bioactive compound the isothiocyanates, particularly sulforaphane.
Based on the findings, researchers said, "There is great promise for the regular use of cruciferous vegetables or supplements containing standardized levels of bioactive in the treatment and prevention of neurologic disorders".
And, " Many clinical and animal studies are underway, and the evidence is building to support this strategy".
Taken altogether, cruciferous vegetables may be considered functional remedies for the prevention of neurological disorders, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Crucifers and related vegetables and supplements for neurologic disorders: what is the evidence? by Panjwani AA1,2, Liu H1,3, Fahey JW. (PubMed)
Neurological disorders are medical conditions characterized by any disorder of the nervous system caused by structural, biochemical, or electrical abnormalities.
There are many forms of neurological disorders. The most common types of the disease are neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease, epilepsy. multiple sclerosis and Migraines.
Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, nutrition-related disease, environment, and physical injuries have been found to be some major prevalent factors that induce the onset of neurological abnormalities.
According to the Medical Press, globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy, etc) has increased substantially over the past 25 years. These may be the results of over 25 years of economic expansion that have increased the living standard of millions of people in the Southeast Asian region.
The WHO in the evaluation of neurological disorder wrote, "Neurological disorders contribute to 92 million disability-adjusted life years (DALYs) in 2005 projected to increase to 103 million in 2030 (approximately a 12% increase). While Alzheimer's and other dementias are projected to show a 66% increase from 2005 to 2030".
Where one DALY represents the loss of the equivalent of one year of full health.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease Alzheimer's disease, and stroke.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for the protection of brain functioning, researchers examined the effects of cruciferous vegetables are a key part of the arsenal of nutrition-based approaches for reducing the risks of neurological disorders.
According to the search of related articles, in animal model systems, cruciferous vegetables exerted protective activity against neurodegenerative disorders like Alzheimer's and Parkinson's diseases.
In chemical analysis, the efficacy of crucifers in the inhibition of the onset and progression of neurological disorders was attributed to its most abundant bioactive compound the isothiocyanates, particularly sulforaphane.
Based on the findings, researchers said, "There is great promise for the regular use of cruciferous vegetables or supplements containing standardized levels of bioactive in the treatment and prevention of neurologic disorders".
And, " Many clinical and animal studies are underway, and the evidence is building to support this strategy".
Taken altogether, cruciferous vegetables may be considered functional remedies for the prevention of neurological disorders, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Crucifers and related vegetables and supplements for neurologic disorders: what is the evidence? by Panjwani AA1,2, Liu H1,3, Fahey JW. (PubMed)
#Bromelain Decreases Interleukins Involved in the Production of Pro-Inflammatory Cytokines Associated with the Onset of Allergic Airway Disease (AAD)
Kyle J. Norton
Chronic allergic airway disease (AAD) is a group of the diseases characterized by airway inflammation and airway hyperresponsiveness (AHR).
Airway inflammation is the hallmark of chronic obstructive pulmonary disease (COPD) associated with low-grade inflammation caused by the persistent production of proinflammatory cytokines by the immune system in the airway.
On the other hand, airway hyperresponsiveness (AHR) is a cardinal feature of asthma associated with the response of the immune system against pathogens.
The most common symptoms of coughing, wheezing, and shortness of breath in reactive airway disease (AAD) may not be due to asthma or other chronic airway conditions.
Conventionally, reactive airway inflammatory disease is treated with medication to control symptoms such as long-term use of an inhaler to relieve attacks and improve quality of life through avoidance of irritants.
If the cause of reactive airway disease is found, most cases of the condition may be cured by medication.
Dr. Jill R. Johnson, the lead scientist in the examination of Allergic Airway Disease: More than Meets the IgE? wrote, "After exposure, allergens crosslink with IgE on mast cells and induce histamine and leukotriene release (6), thereby initiating the allergic response and leading to the classic symptoms of allergy, i.e., sneezing and wheezing".
And, ". Omalizumab binds to the Ce3 domain of free IgE with high affinity (7), thereby inhibiting early- and late-phase asthmatic reactions (8) and decreasing the frequency of exacerbations in severe asthmatics (9). Omalizumab binding also prevents IgE from interacting with Fc«RI and Fc«RII1 on effector cells (mast cells, B cells, eosinophils, dendritic cells, and monocytes), thus impairing their activation and making them less sensitive to allergens, and disabling signaling cascades (10), with the end result of a reduction in symptoms".
In other words, allergic airway disease (AAD) is a result of an immune response upon exposure to the allergens, Therefore, by making the immune system less sensitive to allergens, symptoms of allergic airway disease (AAD) may be reduced.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound for the treatment of diseases associated with chronic inflammation, researchers examined the ability of bromelain to reduce the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
The study included female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days.
On day 4, phosphate-buffered saline (PBS) was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS was administrated to the bromelain (intervention) group (n = 10).
According to the tested assays, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity indicated by reduced BAL total leukocytes, eosinophils, and cellular infiltrates via lung pathology compared to the control group.
Furthermore, bromelain also significantly reduced bronchoalveolar lavage (BAL) CD4+ associated and CD8+ T cells d with the T helper 2 (TH2) cells in the promotion of allergic inflammation process without affecting cell numbers in the spleen or hilar lymph node.
The efficacy of bromelain in the inhibition was attributed to the decreased interleukins involved in the production of pro-inflammatory cytokines.
In other words, bromelain protects asthma patients against allergic airway inflammation through its strong anti-inflammatory properties.
Based on the results, researchers said, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
In order to find more information about bromelain anti-ADD activity, researchers investigated the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
Selected mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols to induce ADD followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.
According to the findings, bromelain showed a similar effect as the aforementioned results in reduced total BAL leukocytes, eosinophils, CD4+, and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.
Taken altogether, bromelain may be considered a supplement for the prevention and treatment of allergic airway disease ADD, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
(3) Allergic Airway Disease: More than Meets the IgE? by Jill R. Johnson, Ph.D. and James A. Harker, Ph.D
Chronic allergic airway disease (AAD) is a group of the diseases characterized by airway inflammation and airway hyperresponsiveness (AHR).
Airway inflammation is the hallmark of chronic obstructive pulmonary disease (COPD) associated with low-grade inflammation caused by the persistent production of proinflammatory cytokines by the immune system in the airway.
On the other hand, airway hyperresponsiveness (AHR) is a cardinal feature of asthma associated with the response of the immune system against pathogens.
The most common symptoms of coughing, wheezing, and shortness of breath in reactive airway disease (AAD) may not be due to asthma or other chronic airway conditions.
Conventionally, reactive airway inflammatory disease is treated with medication to control symptoms such as long-term use of an inhaler to relieve attacks and improve quality of life through avoidance of irritants.
If the cause of reactive airway disease is found, most cases of the condition may be cured by medication.
Dr. Jill R. Johnson, the lead scientist in the examination of Allergic Airway Disease: More than Meets the IgE? wrote, "After exposure, allergens crosslink with IgE on mast cells and induce histamine and leukotriene release (6), thereby initiating the allergic response and leading to the classic symptoms of allergy, i.e., sneezing and wheezing".
And, ". Omalizumab binds to the Ce3 domain of free IgE with high affinity (7), thereby inhibiting early- and late-phase asthmatic reactions (8) and decreasing the frequency of exacerbations in severe asthmatics (9). Omalizumab binding also prevents IgE from interacting with Fc«RI and Fc«RII1 on effector cells (mast cells, B cells, eosinophils, dendritic cells, and monocytes), thus impairing their activation and making them less sensitive to allergens, and disabling signaling cascades (10), with the end result of a reduction in symptoms".
In other words, allergic airway disease (AAD) is a result of an immune response upon exposure to the allergens, Therefore, by making the immune system less sensitive to allergens, symptoms of allergic airway disease (AAD) may be reduced.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound for the treatment of diseases associated with chronic inflammation, researchers examined the ability of bromelain to reduce the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
The study included female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days.
On day 4, phosphate-buffered saline (PBS) was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS was administrated to the bromelain (intervention) group (n = 10).
According to the tested assays, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity indicated by reduced BAL total leukocytes, eosinophils, and cellular infiltrates via lung pathology compared to the control group.
Furthermore, bromelain also significantly reduced bronchoalveolar lavage (BAL) CD4+ associated and CD8+ T cells d with the T helper 2 (TH2) cells in the promotion of allergic inflammation process without affecting cell numbers in the spleen or hilar lymph node.
The efficacy of bromelain in the inhibition was attributed to the decreased interleukins involved in the production of pro-inflammatory cytokines.
In other words, bromelain protects asthma patients against allergic airway inflammation through its strong anti-inflammatory properties.
Based on the results, researchers said, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
In order to find more information about bromelain anti-ADD activity, researchers investigated the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
Selected mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols to induce ADD followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.
According to the findings, bromelain showed a similar effect as the aforementioned results in reduced total BAL leukocytes, eosinophils, CD4+, and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.
Taken altogether, bromelain may be considered a supplement for the prevention and treatment of allergic airway disease ADD, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
(3) Allergic Airway Disease: More than Meets the IgE? by Jill R. Johnson, Ph.D. and James A. Harker, Ph.D
Friday, 6 October 2023
#Healthyfood #CruciferousVegetables Protect Cell Integrity Against DNA Damage Caused by Genotoxicity, Researchers Reveal
Kyle J. Norton
Genotoxicity is a process of destruction o a cell's genetic material (DNA, RNA), leading to gene mutation.
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.
Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.
Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.
The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.
The antigenotoxic activity is a process to inhibit the property of chemical agents that induce damages to the genetic information, leading to mutation,anti-antimutagens
Cancer is a class of diseases associated with alternation of cell DNA or genetic change of cell.
Not all Genotoxicity is mutagenicity, but all mutagens are genotoxic.
Dr. Shareen H, the lead scientist in the study of "Chapter 18 - Genotoxicity and Cancer" wrote, "Genetic toxicology is the study of chemical and physical perturbations to DNA following exposure to endogenous or exogenous agents. Hazard assessment of engineered nanomaterials involves establishing the ability of these novel materials to induce DNA damage (genotoxicity) and to subsequently initiate tumor formation (carcinogenesis)".
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
Iand n finding a potential compound for the protection of cell DNA against damage, researchers examined the effects of cruciferous vegetables (CF) in protecting humans against cancer caused by chemically induced tumor formation.
According to the dietary information,* CF and their constituents showed the effect on enzymes involved in the metabolism of DNA-reactive carcinogens.
* In vitro models, sulforaphane, a bioactive compound found in CF exerted antigenotoxic effects on metabolically competent cell lines.
* Furthermore, Brassica juices induced the production of glutathione-S-transferases (GST) and cytochrome P-450 1A2 in human hepatoma cells (HepG2) against the genotoxic effects of B(a)P and other carcinogens.
* Moreover, brussels sprouts- and garden cress juices attenuated IQ-induced DNA damage and preneoplastic lesions in the colon and liver of rats.
* Most importantly, CF affects drug metabolism in humans and consumption of red cabbage led to changes in the pattern of meat-derived urinary mutagenicity.
Taken together, cruciferous vegetables may be considered functional foods for the protection of the cells against genotoxicity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose WeightNorton's
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of cruciferous vegetables and their constituents on drug-metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens by Steinkellner H1, Rabot S, Freywald C, Nobis E, Scharf G, Chabicovsky M, Knasmüller S, Kassie F. (PubMed)
b(2) Chapter 18 - Genotoxicity and Cancer by Shareen H.Doak, Ying Liu, and ChunyingChen. (Science Direct)
Genotoxicity is a process of destruction o a cell's genetic material (DNA, RNA), leading to gene mutation.
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.
Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.
Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.
The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.
The antigenotoxic activity is a process to inhibit the property of chemical agents that induce damages to the genetic information, leading to mutation,anti-antimutagens
Cancer is a class of diseases associated with alternation of cell DNA or genetic change of cell.
Not all Genotoxicity is mutagenicity, but all mutagens are genotoxic.
Dr. Shareen H, the lead scientist in the study of "Chapter 18 - Genotoxicity and Cancer" wrote, "Genetic toxicology is the study of chemical and physical perturbations to DNA following exposure to endogenous or exogenous agents. Hazard assessment of engineered nanomaterials involves establishing the ability of these novel materials to induce DNA damage (genotoxicity) and to subsequently initiate tumor formation (carcinogenesis)".
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
Iand n finding a potential compound for the protection of cell DNA against damage, researchers examined the effects of cruciferous vegetables (CF) in protecting humans against cancer caused by chemically induced tumor formation.
According to the dietary information,* CF and their constituents showed the effect on enzymes involved in the metabolism of DNA-reactive carcinogens.
* In vitro models, sulforaphane, a bioactive compound found in CF exerted antigenotoxic effects on metabolically competent cell lines.
* Furthermore, Brassica juices induced the production of glutathione-S-transferases (GST) and cytochrome P-450 1A2 in human hepatoma cells (HepG2) against the genotoxic effects of B(a)P and other carcinogens.
* Moreover, brussels sprouts- and garden cress juices attenuated IQ-induced DNA damage and preneoplastic lesions in the colon and liver of rats.
* Most importantly, CF affects drug metabolism in humans and consumption of red cabbage led to changes in the pattern of meat-derived urinary mutagenicity.
Taken together, cruciferous vegetables may be considered functional foods for the protection of the cells against genotoxicity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose WeightNorton's
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of cruciferous vegetables and their constituents on drug-metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens by Steinkellner H1, Rabot S, Freywald C, Nobis E, Scharf G, Chabicovsky M, Knasmüller S, Kassie F. (PubMed)
b(2) Chapter 18 - Genotoxicity and Cancer by Shareen H.Doak, Ying Liu, and ChunyingChen. (Science Direct)
#Honey Enhances the Immune Function in Speeding Up Wound Healing, Researchers Say
Kyle J. Norton
Honey may have a strong effect in speeding up wound healing, some scientists suggested.
Wound healing is the natural process of covering up the damage and injury of the body,
The process involves 4 phases
* The first phase of wound healing is to cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block drainage.
* In phase 2, the white blood cells activate the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.
* In phase 3, new blood vessels and tissues are formed in the damage and injury area.
* The recovery phase.
However, the healing process is easier said than done, the complex process in many cases are interrupted by local and systemic factors, including moisture, infection, age, and nutritional status.
Some researchers also indicated that in phase 2, due to overexpression of inflammatory cytokine, some patients may experience symptoms of localized redness, swelling, and fever.
And, the overexpression of inflammatory cytokines can also cause damage to the nearby healthy cells, leading to improper healing with the formation of large and irreversible scars.
However, people with a weakened immune system may compromise acute wound repair that promotes nonhealing wounds.
Dr. Amanda S. MacLeod, the lead author in the concerns of the immune responses to acute and chronic wounds said, "The innate immune system comprises a network of interacting mechanisms that provide a rapid response to clear microbial contamination upon skin injury" and "In the development of chronic wounds, this process stalls in the late inflammatory stage. The major defect in nonhealing wounds occurs at the phenotypic switch from inflammatory macrophages to an anti-inflammatory phenotype".
These results clearly, suggested, that the failure to switch from the phase of proinflammatory cytokines to the phase of anti-inflammatory cytokines due to the weakened immune system in the activation of p38, can lead to delayed wound healing and abnormalities in chronic wounds.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In the traditional use of honey for wound healing and an alternative natural antibiotic due to the advent of antibiotic resistance in microbial pathogens, researchers reviewed articles outlined in publications regarding honey and wound healing that were published between June 2010 and August 2016.
The findings suggested that multiple types of honey demonstrate their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators.
In the evaluation to examine the healing effects of honey dressings compared to silver dressings for acute or chronic wounds, researchers launched a systematic review with meta-analysis consisting of six randomized controlled trial studies.
All studies showed that honey was more efficacious for wound healing than silver, as measured in the number of days needed for wounds to heal.
Honey turned out to have more antibacterial qualities than silver in-depth analysis.
Dr. Lindberg T, the lead scientist after taking into account co and confounders, said, "All the included studies based on burns showed the unequivocal result that honey had an even more positive effect than silver on wound healing".
The results pointed out that honey may have a potential effect in speeding up wound healing and protecting the wound against microorganism infection.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Honey and Wound Healing: An Update by Saikaly SK1, Khachemoune A2. (PubMed)
(2) A systematic review and meta-analysis of dressings used for wound healing: the efficiency of honey compared to silver on burns by Lindberg T1, Andersson O1, Palm M1, Fagerström C, (PubMed)
(3) Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis by Oryan A1, Alemzadeh E2, Moshiri A3. (PubMed)
(4) The Innate Immune System in Acute and Chronic Wounds by Amanda S. MacLeod1, and Jonathan N. Mansbridge. (PMC)
Honey may have a strong effect in speeding up wound healing, some scientists suggested.
Wound healing is the natural process of covering up the damage and injury of the body,
The process involves 4 phases
* The first phase of wound healing is to cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block drainage.
* In phase 2, the white blood cells activate the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.
* In phase 3, new blood vessels and tissues are formed in the damage and injury area.
* The recovery phase.
However, the healing process is easier said than done, the complex process in many cases are interrupted by local and systemic factors, including moisture, infection, age, and nutritional status.
Some researchers also indicated that in phase 2, due to overexpression of inflammatory cytokine, some patients may experience symptoms of localized redness, swelling, and fever.
And, the overexpression of inflammatory cytokines can also cause damage to the nearby healthy cells, leading to improper healing with the formation of large and irreversible scars.
However, people with a weakened immune system may compromise acute wound repair that promotes nonhealing wounds.
Dr. Amanda S. MacLeod, the lead author in the concerns of the immune responses to acute and chronic wounds said, "The innate immune system comprises a network of interacting mechanisms that provide a rapid response to clear microbial contamination upon skin injury" and "In the development of chronic wounds, this process stalls in the late inflammatory stage. The major defect in nonhealing wounds occurs at the phenotypic switch from inflammatory macrophages to an anti-inflammatory phenotype".
These results clearly, suggested, that the failure to switch from the phase of proinflammatory cytokines to the phase of anti-inflammatory cytokines due to the weakened immune system in the activation of p38, can lead to delayed wound healing and abnormalities in chronic wounds.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In the traditional use of honey for wound healing and an alternative natural antibiotic due to the advent of antibiotic resistance in microbial pathogens, researchers reviewed articles outlined in publications regarding honey and wound healing that were published between June 2010 and August 2016.
The findings suggested that multiple types of honey demonstrate their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators.
In the evaluation to examine the healing effects of honey dressings compared to silver dressings for acute or chronic wounds, researchers launched a systematic review with meta-analysis consisting of six randomized controlled trial studies.
All studies showed that honey was more efficacious for wound healing than silver, as measured in the number of days needed for wounds to heal.
Honey turned out to have more antibacterial qualities than silver in-depth analysis.
Dr. Lindberg T, the lead scientist after taking into account co and confounders, said, "All the included studies based on burns showed the unequivocal result that honey had an even more positive effect than silver on wound healing".
The results pointed out that honey may have a potential effect in speeding up wound healing and protecting the wound against microorganism infection.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Honey and Wound Healing: An Update by Saikaly SK1, Khachemoune A2. (PubMed)
(2) A systematic review and meta-analysis of dressings used for wound healing: the efficiency of honey compared to silver on burns by Lindberg T1, Andersson O1, Palm M1, Fagerström C, (PubMed)
(3) Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis by Oryan A1, Alemzadeh E2, Moshiri A3. (PubMed)
(4) The Innate Immune System in Acute and Chronic Wounds by Amanda S. MacLeod1, and Jonathan N. Mansbridge. (PMC)
#Coffee Processes Anti Edema Activity through its Effects on Lipid Peroxidation (LPO) and Antioxidant Expression , According to Researchers
Kyle J. Norton
Good news for coffee drinkers, coffee may have a potential effect in reducing the risk and treatment of edema, a recent study suggested.
Edema is a condition characterized by excess fluid retained in the body's tissues, inducing swelling.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
According to the joint study led by Kyung Hee University, chlorogenic acid (CGA) isolated from coffee exerted protective effects of transient middle cerebral artery occlusion (tMCAo) rat model in ameliorated brain infarct volume and brain water content.
The protective effect in reduced ischemia-induced neuronal damage and brain edema.is attributed to dihydrocaffeic acid (DHCA, formed in the metabolism of CGA in inhibited enzymes involved in the degradation of the extracellular matrix, namely MMP2 and MMP-9. in providing structural and biochemical support to the surrounding cells.
In a rat model of transient middle cerebral artery occlusion, CGA directly showed significantly reduced brain water content, by the inhibitory effects on MMP-2 and MMP-9 activities.
The study also addressed that the attenuation of brain edema may also be affected by the chemical compound's anti-lipid peroxidation (LPO) activity through increased antioxidant expression.
In another study in the investigation of anti-inflammatory activity against carrageenan, PGE(2), and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, chlorogenic acid (CGA), researchers at the Gazi University postulated.
The findings suggested that coffee may be used as a functional and therapeutic beverage for reduced risk and treatment of edema, more studies are necessary to confirm the promising validity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwideKarate health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model by Lee K1, Lee BJ2, Bu Y3.(PubMed)
(2) Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia by Lee K1, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y.(PubMed)
(3) Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects by Küpeli Akkol E1, Bahadır Acıkara O, Süntar I, Ergene B, Saltan Çitoğlu G.(PubMed)
Good news for coffee drinkers, coffee may have a potential effect in reducing the risk and treatment of edema, a recent study suggested.
Edema is a condition characterized by excess fluid retained in the body's tissues, inducing swelling.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
According to the joint study led by Kyung Hee University, chlorogenic acid (CGA) isolated from coffee exerted protective effects of transient middle cerebral artery occlusion (tMCAo) rat model in ameliorated brain infarct volume and brain water content.
The protective effect in reduced ischemia-induced neuronal damage and brain edema.is attributed to dihydrocaffeic acid (DHCA, formed in the metabolism of CGA in inhibited enzymes involved in the degradation of the extracellular matrix, namely MMP2 and MMP-9. in providing structural and biochemical support to the surrounding cells.
In a rat model of transient middle cerebral artery occlusion, CGA directly showed significantly reduced brain water content, by the inhibitory effects on MMP-2 and MMP-9 activities.
The study also addressed that the attenuation of brain edema may also be affected by the chemical compound's anti-lipid peroxidation (LPO) activity through increased antioxidant expression.
In another study in the investigation of anti-inflammatory activity against carrageenan, PGE(2), and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, chlorogenic acid (CGA), researchers at the Gazi University postulated.
The findings suggested that coffee may be used as a functional and therapeutic beverage for reduced risk and treatment of edema, more studies are necessary to confirm the promising validity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwideKarate health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model by Lee K1, Lee BJ2, Bu Y3.(PubMed)
(2) Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia by Lee K1, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y.(PubMed)
(3) Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects by Küpeli Akkol E1, Bahadır Acıkara O, Süntar I, Ergene B, Saltan Çitoğlu G.(PubMed)
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