Friday, 6 October 2023

#Honey Enhances the Immune Function in Speeding Up Wound Healing, Researchers Say

Kyle J. Norton

Honey may have a strong effect in speeding up wound healing, some scientists suggested.
Wound healing is the natural process of covering up the damage and injury of the body,

The process involves 4 phases
* The first phase of wound healing is to cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block drainage.

* In phase 2, the white blood cells activate the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.

* In phase 3, new blood vessels and tissues are formed in the damage and injury area.

* The recovery phase.

However, the healing process is easier said than done, the complex process in many cases are interrupted by local and systemic factors, including moisture, infection, age, and nutritional status.

Some researchers also indicated that in phase 2, due to overexpression of inflammatory cytokine, some patients may experience symptoms of localized redness, swelling, and fever.


And, the overexpression of inflammatory cytokines can also cause damage to the nearby healthy cells, leading to improper healing with the formation of large and irreversible scars.

However, people with a weakened immune system may compromise acute wound repair that promotes nonhealing wounds.


Dr. Amanda S. MacLeod, the lead author in the concerns of the immune responses to acute and chronic wounds said, "The innate immune system comprises a network of interacting mechanisms that provide a rapid response to clear microbial contamination upon skin injury" and "In the development of chronic wounds, this process stalls in the late inflammatory stage. The major defect in nonhealing wounds occurs at the phenotypic switch from inflammatory macrophages to an anti-inflammatory phenotype".

These results clearly, suggested, that the failure to switch from the phase of proinflammatory cytokines to the phase of anti-inflammatory cytokines due to the weakened immune system in the activation of p38, can lead to delayed wound healing and abnormalities in chronic wounds.


Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.

In the traditional use of honey for wound healing and an alternative natural antibiotic due to the advent of antibiotic resistance in microbial pathogens, researchers reviewed articles outlined in publications regarding honey and wound healing that were published between June 2010 and August 2016.
The findings suggested that multiple types of honey demonstrate their mechanisms of action as antimicrobial agents, immunologic modulators, and physiologic mediators.

In the evaluation to examine the healing effects of honey dressings compared to silver dressings for acute or chronic wounds, researchers launched a systematic review with meta-analysis consisting of six randomized controlled trial studies.

All studies showed that honey was more efficacious for wound healing than silver, as measured in the number of days needed for wounds to heal.

Honey turned out to have more antibacterial qualities than silver in-depth analysis.

Dr. Lindberg T, the lead scientist after taking into account co and confounders, said, "All the included studies based on burns showed the unequivocal result that honey had an even more positive effect than silver on wound healing".

The results pointed out that honey may have a potential effect in speeding up wound healing and protecting the wound against microorganism infection.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Honey and Wound Healing: An Update by Saikaly SK1, Khachemoune A2. (PubMed)
(2) A systematic review and meta-analysis of dressings used for wound healing: the efficiency of honey compared to silver on burns by Lindberg T1, Andersson O1, Palm M1, Fagerström C, (PubMed)
(3) Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis by Oryan A1, Alemzadeh E2, Moshiri A3. (PubMed)
(4) The Innate Immune System in Acute and Chronic Wounds by Amanda S. MacLeod1, and Jonathan N. Mansbridge. (PMC)

#Coffee Processes Anti Edema Activity through its Effects on Lipid Peroxidation (LPO) and Antioxidant Expression , According to Researchers

Kyle J. Norton

Good news for coffee drinkers, coffee may have a potential effect in reducing the risk and treatment of edema, a recent study suggested.
Edema is a condition characterized by excess fluid retained in the body's tissues, inducing swelling.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

According to the joint study led by Kyung Hee University, chlorogenic acid (CGA) isolated from coffee exerted protective effects of transient middle cerebral artery occlusion (tMCAo) rat model in ameliorated brain infarct volume and brain water content.

The protective effect in reduced ischemia-induced neuronal damage and brain edema.is attributed to dihydrocaffeic acid (DHCA, formed in the metabolism of CGA in inhibited enzymes involved in the degradation of the extracellular matrix, namely MMP2 and MMP-9. in providing structural and biochemical support to the surrounding cells.

In a rat model of transient middle cerebral artery occlusion, CGA directly showed significantly reduced brain water content, by the inhibitory effects on MMP-2 and MMP-9 activities.

The study also addressed that the attenuation of brain edema may also be affected by the chemical compound's anti-lipid peroxidation (LPO) activity through increased antioxidant expression.

In another study in the investigation of anti-inflammatory activity against carrageenan, PGE(2), and serotonin-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models, chlorogenic acid (CGA), researchers at the Gazi University postulated.


The findings suggested that coffee may be used as a functional and therapeutic beverage for reduced risk and treatment of edema, more studies are necessary to confirm the promising validity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwideKarate health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model by Lee K1, Lee BJ2, Bu Y3.(PubMed)
(2) Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia by Lee K1, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y.(PubMed)
(3) Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects by Küpeli Akkol E1, Bahadır Acıkara O, Süntar I, Ergene B, Saltan Çitoğlu G.(PubMed)

#Greentea Inhibits Parameter Associated with the Risk of Hypertension, Reserachers Suggest

Kyle J. Norton

Regular drinking of green tea may have a potential effect on maintaining normal blood pressure and reducing the risk of hypertension, a recent study suggested.
Hypertension is an abnormal high of blood pressure, one of the major risk factors in the contributed early onset of cardiovascular disease.

Green tea, considered a functional food, has a number of health benefits and has been reported by several renowned research and studies. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding one slice of ginger will do the trick of neutralization.

Hypertension of male Wistar rats induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20 mg/kg per day, orally, for 2 weeks], fed with green tea extract exhibited a strong effect in reduced hypertension (119 ± 1 mmHg) and higher renal sympathetic nerve activity (161 ± 12 spikes/s) than the control group (97 ± 2 spikes/s).
Green tea oral administration also showed a significant decrease in hypertensive parameters by amelioration. arterial baroreceptor function and vascular and systemic oxidative stress.

Furthermore, a total of 20 Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 13 weeks old with metabolic syndrome were randomized into a saline-treated group (OLETF; n = 10) and a group treated with decaffeinated-GTE (25 mg/kg/day) (GTE-OLETF; n = 10), group fed with decaffeinated-GTE significantly reduced BP (OLETF vs. GTE-OLETF; 130 ± 7 vs. 121 ± 3 mmHg, p = 0.01) in compared control fed with saline.

The study also suggested that fed mice with green tea also showed an antihypertensive effect in reduced vascular reactive oxygen species (ROS) formation and NADPH in the generation of ROS, as well as improving endothelium (cell lines the interior surface of blood vessels and lymphatic vessels)and lymphatic vessels dependent relaxation.

Dr. Ihm SH, the lead author said," (green tea extract) improved endothelial dysfunction and IR, and eventually lowered BP".

Taken together, there is no doubt that green tea processes a significant effect in reduced risk and treatment of hypertension through reduced oxidative stress and improved vascular relaxation as well as decreased metabolic syndrome in exaggerated hypertension.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) The antioxidant effects of green tea reduce blood pressure and sympathoexcitation in an experimental model of hypertension by Garcia ML1, Pontes RB, Nishi EE, Ibuki FK, Oliveira V, Sawaya AC, Carvalho PO, Nogueira FN Franco MD, Campos RR, Oyama LM, Bergamaschi CT.(PubMed)
(2) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)

#Ginger Exerts Anti-#Arteriosclerosis Activity By Inhibiting Pathways Associated with Cholesterol Synthesis and Lipid Accumulation

Kyle J. Norton

Scientists may have found a natural remedy that has the potential to treat chronic mild stress, according to studies.
Acute stress is a natural and emotional reaction that arises in response to a terrifying or traumatic event or witnessing a traumatic event. People react to acute stress differently depending on life experiences.

Chronic stress, a medical condition is a result of a person who can not respond to emotional pressure properly, leading to traumatic stress which he or she can not control.

Untreated ongoing chronic stress has been found to exacerbate many serious health conditions, including depression, anxiety, and personality disorders.


Epidemiological studies suggested that certain physical health problems are also associated with patients with long-term stress, including heart disease, high blood pressure, abnormal heart rhythms, heart attacks, and stroke.


There are many risk factors involving the onset of chronic stress. However, job-related chronic stress has been found in most American adults in the Western world.

The American Institute of Stress in examining the chronic stress in American adults wrote, "Numerous studies show that job stress is far and away from the major source of stress for American adults and that it has escalated progressively over the past few decades. Increased levels of job stress as assessed by the perception of having little control but lots of demands have been demonstrated to be associated with increased rates of heart attack, hypertension, and other disorders".

According to the American Workplace VII statistics, 80% of workers feel stress on the job, nearly half say they need help in learning how to manage stress and 42% say their coworkers need such help.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding natural ingredients or whole food for the treatment of chronic mild stress (CMS), a major contribution to atherosclerosis in the previous study examined the effects of 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale) anti-chronic stress activity.

6-gingerol (6-Gin) has long been found to process numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects, according to epidemiological studies.

CMS ApoE-/- mice used in the study were given a high-fat diet (HFD) to induce the development of atherosclerosis in-fed before administrating 6-Gin.



Mice were exposed to CMS for 20 weeks, at week 5, they were fed with a high-fat diet (HFD), then received 6-Gin (20 mg/kg/day, intragastrically) treatment.

CMS before application of a high-fat diet exerted a significant effect in reducing body weight gain, sucrose preference, and locomotor activity, the expression of some of the core symptoms of depression.


Furthermore, CMS mice fed with a high-fat diet (HFD) after week 5 also showed increased plaque formation, the elevation of plasma total cholesterol, triglyceride, low-density lipoprotein cholesterin, and proinflammatory cytokines including TNF-α, IL-1β, and IL-6, all indicated the development of atherosclerotic lesions.

However, the injection of 6-Gin not only reduced the expression induced by a high-fat diet but modulated the function of enzymes activated glucose and fatty acid uptake and oxidation, catalyzed the committed step in fatty acid synthesis, produced cholesterol, and other isoprenoids, particularly the lipid synthesis in the liver tissues.

These results suggested the role of ginger in alleviating atherosclerotic lesions and reversed the expression levels of lipid profiles and inflammatory cytokines in stressed mice.

Dr. Wang S, the lead scientist wrote, "The antiatherosclerotic effects of 6-Gin is mediated in part by the AMPK signaling pathway, which is closely associated with cholesterol synthesis and lipid accumulation".


Where AMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis, in response to low glucose, hypoxia, ischemia, and heat shock.

Additionally, CMS also showed an improvement in several aspects of chronic stress on the injection of 6-Gin.

The finding clearly suggested that 6-Gin attenuates arteriosclerosis in ApoE-/- mice exposed to CMS and HFD, and it may be a potential therapeutic agent for the treatment of atherosclerosis similar to that of conventional medicine.


Taken altogether, ginger-processed abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of chronic mild stress and atherosclerosis, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress by Wang S1, Tian M2, Yang R1, Jing Y1, Chen W1, Wang J1, Zheng X1, Wang F. (PubMed)
(2) Transforming stress through awareness, education, and collaboration by AIS

#ManukaHoney Eye Drops (Optimel, Melcare, Australia) in the Treatment of #OcularDemodex and #DryEye, Reserachers Say

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of Ocular Demodex and Dry-Eye, according to studies.

Believe it or not, the Demodex in eyelashes that cause the severity of ocular discomfort is quite common in the US. According to US Federal Science, over 70% of Americans suffer from the presence of Demodex without even noticing.

The increase in age, and patients with conjunctival papillary hypertrophy, are some most common Demodex risk factors.

Furthermore, methicillin-resistant Staphylococcus aureus (MRSA) was detected more often on eyelids with Demodex.


The finding strongly suggested that Demodex plays a pathogenic role in the ocular discomfort linked with aging.

Dry eye happens mostly in older adults is a condition in which a person doesn't have enough quality tears to clean and nourish the eye, leading to a chronic vision problem.

Dry eye, in most cases, is caused by the inadequate amount of tears due to lower than normal amount of tear production or tears evaporating too quickly from the eyes and poor quality of tears.

People with dry eyes may experience symptoms of irritation, gritty, scratchy or burning eyes; a feeling of something in their eyes; excess watering; and blurred vision.

Honey is a miraculous product made by bees using nectar from flowers.,

The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

Researchers with an aim to find a natural source for the treatment of vision problem compared the Manuka honey and tea tree oil against ocular Demodex.

The study included 53 viable Demodex mites acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Then, the viable mites were randomized to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment.

Compared to the results of four treatments, researchers found that the survival probabilities are lowest with 100% tea tree oil, and highest with cyclodextrin-complexed and uncomplexed Manuka Honey.

The finding clearly suggested that the efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex.

In order to reveal more information about honey anti-dry eye effects, researchers evaluated
the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia).

The study included 24 participants aged 20 to 55 years with contact lens-related dry eye randomized to two treatment groups with 20 completing the study.


One group received Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks while the other group completed the treatments in the reverse order.

The Optimal treatment exerted an improvement in Dry eye symptoms significantly and patients with more severe symptoms at baseline showed a greater improvement in symptoms.

Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.

However, due to the short duration of treatment, there were no significant differences observed in the objective signs of a dry eye.

Researchers at the experiment wrote in the final report, "Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use".

Taken together, honey, particularly Tualang honey may be considered a functional remedy for the prevention and treatment of ocular Demodex and dry eye, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.carights


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Comparing the in vitro effects of MGO™ Manuka honey and tea tree oil on ocularDemodex viability by Frame K1, Cheung IMY2, Wang MTM2, Turnbull PR1, Watters GA2, Craig JP. (PubMed)
(2) Treatment of contact lens related dry eye with antibacterial honey by Wong D1, Albietz JM1, Tran H1, Du Toit C1, Li AH1, Yun T1, Han J1, Schmid KL. (PubMed)

#Ginger Exerts Strong Cytotoxicity and Antioxidant Activities, According to Studies

Kyle J. Norton

Scientists may have found a kitchen spice that processes the potential to induce cancer cell death by cytotoxicity, according to studies.
Cytotoxicity is a process that stimulates the ability of certain chemicals or mediator cells to destroy living cells.

In herbal medicine, injection of plant extracts in some cases also induce cytotoxic effects to kill cancer cells without causing harm to nearby healthy cells through the protection of increased production of antioxidant enzymes.

In other words, the use of herbal medicine for the treatment of cancer can induce no side effects.

In cancer, the cytotoxic activity is carried out by the overexpression reactive oxygen activity, leading to cancer cell apoptosis through a number of mechanisms, including cell death programming and cell cycle arrest proteins.

In healthy cells, the ROS cytotoxic activity can also cause significant damage to the proteins, lipids, and DNA, leading to the onset of chronic diseases, including cancer.


Some researchers suggested that activating the expression gene associated with tumor suppression to prevent the damage of healthy cells during the injection of chemo drugs may provide a necessary step for the prevention of chemo side effects in cancer patients.

Dr. Chit Fang Cheok, in the differentiation of protecting normal cells from the cytotoxicity of chemotherapy, wrote, "The occurrence of intolerable side effects in patients undergoing chemotherapy is still a major clinical hurdle. Finding tumor-specific therapy and exploiting the differences between normal cells and tumor cells has led to strategies targeting oncogenic mutations or the deficiency of tumor suppressor pathways in cancers".

And, "The concept requires the use of two drugs, the first to arrest the normal cells and the second, to kill only cycling (tumor) cells".


More interestingly, "several recent studies demonstrate that p53 activation protects normal cells from the toxicity of drugs acting in the S-phase or M-phase, including Ara-C,2 taxol,3 Aurora kinase inhibitors4, and Polo-like kinase inhibitors".


These results strongly suggested the model provided by herbal medicine may some days be used by conventional medicine for the treatment of cancer without causing severe side effects.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers to find a natural ingredient for the treatment of cancer examined ginger's cytotoxic activity on cancer cells.

In vivo, researchers compared the anticancer effect of ginger in a total of 80 OV and nitrosamine (OV/ DMN)-induced CCA hamsters fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days vs control groups consisting of 10 hamsters for each group fed with 5-fluorouracil (positive control) or distilled water (untreated control).

Injection of crude ethanolic extracts of ginger at a dose of 10.95, 53.15, and 27.86 μg/ml with Median IC50 (concentration that inhibits cell growth by 50%) values exerted strong cytotoxicity and antioxidant activities.

The crude ethanolic extracts of ginger demonstrated a 7-9 fold in the function of genes associated with the transportation of the chemo drugs observed by the DNA fragments on the cancer cell line.

The extract also induced acute and subacute toxicity at the maximum dose of 5,000 mg/kg body weight.

Furthermore, the injection displayed a strong effect on the survival time and survival rate of the CCA-bearing hamsters compared to the control group (median of 54 vs 17 weeks.

Dr. Plengsuriyakarn T, the lead scientist said, "Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity".

Moreover, in the examined ginger anti-cancer activity, researchers investigated the cytotoxic and antitumor activity of ginger essential oil (GEO).
GEO showed potent in vitro cytotoxic activity against DLA and EAC cell lines. The IC50 values for the DLA cell line and EAC cell line were 18 μg/ml. were found to be 11 μg/ml and 18 μg/ml, respectively.

However, on L929 cell lines and to Vero cells, The IC50 of GEO was found to be 41 μg/ml and ˃100 ug/ml, respectively, significantly higher compared to the DLA cell line and EAC cell line.

Additionally, treatment with GEO (500 mg/kg and 1000 mg/kg body weight) significantly reduced the volume of solid tumor development by 54.4% and 62.4% respectively and the lifespan was increased up to 50% in 1000 mg/kg b. wt GEO treated ascites tumor-induced animals.


The findings once again, reconfirm the cytotoxic and antitumor effects of ginger.

Taken together, ginger, the kitchen, and pungent spice may be considered a functional food for the prevention and combined with primary therapy for the treatment of cancer with no or little side effects, pending the validity of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Cytotoxicity, toxicity, and anticancer activity of Zingiber officinale Roscoe against cholangiocarcinoma by Plengsuriyakarn T1, Viyanant V, Eursitthichai V, Tesana S, Chaijaroenkul W, Itharat A, Na-Bangchang K. (PubMed)
(2) Antitumor and cytotoxic activity of ginger essential oil (Zingiber officinale roscoe) by Jeena Kottarapat, Vijayasteltar B Liju, R. Kuttan. (Research Gate)
(3) Protecting normal cells from the cytotoxicity of chemotherapy by Chit Fang Cheok. (PMC)

#GreenTea Shows a Signoificant and Positive Effect on #MetabolicSyndrome, Reserachers Suggest

Kyle J. Norton

A recent study conducted by renowned institutes suggested that regular drinking of green tea may reduce the risk of prevalence of metabolic syndrome.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Metabolic syndrome is a biochemical and physiological factor associated with the risk of cardiovascular disease and type 2 diabetes.

In a cross-sectional population-based survey including 8,821 adults (51.4% female) conducted in Krakow, Poland., both coffee and tea drinkers showed a negative association with MetS (OR 0.75, 95% CI 0.66, 0.86 and OR 0.79, 95% CI 0.67, 0.92, respectively).

The study also found that high tea consumers had lower BMI, and waist circumference, but moderated decreased diastolic blood pressure, as well as negatively correlated central obesity and fasting plasma glucose in women, but not in men, compared to low drinkers,


Other, in the study of dietary polyphenols, a major compound found in green tea including 8821 adults (51.4 % female), using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database. conducted in Kraków, Poland, dietary polyphenol intake in the highest quartile was associated inversely to the development of MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively).
g
Dietary polyphenols in high quality showed a negative association of WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both genders.

Dr. Grosso G, the lead author said, "(Depending on types of polyphenols) phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose" and " Among specific subclasses of polyphenols, hydroxycinnamic acids, flavonols, and dihydrochalcones had the most relevant role."

In support of the role of used of polyphenols in the treatment of Metabolic syndrome, a total of 2725 participants free of hypertension at baseline tested for blood pressure or taking hypertensive medication within the last 2 weeks at 2-4-year follow-up visit was conducted by the Integrated Cancer Registry of Catania-Messina-Siracusa-Enna, researchers showed that diet of highest quartile of total polyphenol intake was associated with 31% decreased risk of hypertension compared with the lowest intake (OR 0.69, 95% CI 0.48, 0.98) in women with no significant association in men.

The study also stated that the most influential phytochemicals in reduced risk and treatment of metabolic syndrome ingredients are phenolic acids, and hydroxycinnamic acids as they showed independently associated with lower odds of hypertension (OR 0.66, 95% CI 0.47, 0.93) in comparison to others.

Taken together, green tea with major chemical compounds of polyphenol may be used as a functional food in the prevention and treatment of metabolic syndrome.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Sources
(1) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3. (PubMed)
(2) Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Stefler D4, Bobak M4, Pająk A3. (PubMed)
(3) Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Kozela M3, Stefler D4, Bobak M4, Pajak A3.(PubMed)