#Cranberry Inhibits Parameters Associated with the Onset of #CardiovascularDisease, According to Studies

Kyle J. Norton

Cardioprotection is an action that contributes to the protection of heart and blood vessels integrity against damage or injury, including heart diseases, and stroke.

In other words, cardioprotection is a process in which substances or medicines are used including an herbal remedy to protect heart muscle tissues against ischemic insult and deoxygenation injury.

Cardiovascular diseases (CVD) are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.

According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015 were in men, comapred to women.

Believe it or not, more than 63),000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.

On another hand, stroke is a medical condition caused by poor blood flow to the brain, leading to brain cell death in the affected region.

The most common types of stroke are ischemic stroke associated with the obstruction of a blood vessel supplying blood to the brain and hemorrhagic stroke associated with small blood vessel ruptures. The most common cause of stroke is unmanaged high blood pressure.

The US statistics indicate that stroke is the leading cause of long-term disability in the United States. Each year, more than 79o,000 people suffer a stroke, including 600,000 of first attacks, and 185,000 recurrent attacks.

Coronary artery disease caused by narrowing of the arteries, heart attack, abnormal heart rhythms, or arrhythmias and stroke is the most common type of cardiovascular disease found in the Western world.

The most common symptoms of CVD include persistent fatigue, shortness of breath, irregular heartbeat, chest pain, and fainting.

If you have some of the aforementioned symptoms, please make sure that you check with your doctor to rule out the CVD possibility.

The exact causes of cardiovascular diseases are unidentified. However, according to epidemiological studies, the most prevalent factor that causes an increased risk of CVD is an unhealthy lifestyle correlated to the promotion of the Western diet.

Dr. Oikonomou E and colleagues in the joint study led by the National and Kapodistrian University of Athens wrote, "... Western dietary pattern (increased intake of fat, red meat, and carbohydrates and minimal consumption of fruits and green leafy vegetables) was predictive of severe CAD (area under the curve: 0.73, 95% confidence intervals: 0.64-0.83, P < .001)".

And, "an unhealthy Western type of diet is associated with the severity of coronary artery lesions in patients with stable CAD. These findings highlight the role of dietary patterns when estimating cardiovascular risk for the management of patients with CAD".

The results strongly suggested that lifestyle change has a strong implication in the prevention of CVD.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of heart disease and stroke, researchers examined the efficacy of cranberry supplementation on cardiovascular disease metabolic risk factors in adult populations.

The systematic review is conducted by searching the databases of PubMed, Scopus, Web of Science, and Google Scholar up to June 2018, to identify randomized controlled trials investigating the effect of cranberry supplementation on cardiovascular metabolic risk factors.

According to the results from the review of the pooled effect size, cranberry administration decreased the risk of CVD by significantly reducing systolic blood pressure and body mass index.

However, other parameters associated with the metabolic risks such as triacylglycerol, total cholesterol, low-density lipoprotein, high-density lipoprotein, fasting plasma glucose, fasting insulin, homeostasis model assessment of insulin resistance, diastolic blood pressure, waist circumference, C-reactive protein, and intercellular adhesion molecule were not changed much after cranberry administration.

Furthermore, the reduction of SBP was more pronounced in patients with age ≥50 comapred to the younger age group.

Moreover, comapred to no change in supplemental administration, there was also a significant increase in high-density lipoprotein concentrations in subgroups with subjects <50 mean age and triacylglycerol levels in subsets with cranberry administered in juice form.

Based on the findings, researchers concluded. " cranberry supplementation may be effective in managing systolic blood pressure, body mass index, and high-density lipoprotein in younger adults. Further high-quality studies are needed to confirm these results.".

Taken together, cranberry may be considered a remedy for the prevention and treatment of CVD, pending the confirmation of the larger sample size and multicenter human study.


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How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of cranberry on cardiovascular metabolic risk factors: A systematic review and meta-analysis by Pourmasoumi M1, Hadi A2, Najafgholizadeh A3, Joukar F4, Mansour-Ghanaei F. (PubMed)
(2) Western Dietary Pattern Is Associated With Severe Coronary Artery Disease by Oikonomou E1, Psaltopoulou T2, Georgiopoulos G1, Siasos G1,3, Kokkou E1, Antonopoulos A1, Vogiatzi G1, Tsalamandris S1, Gennimata V1, Papanikolaou A1, Tousoulis D. (PubMed)

#Bromelain Inhibits Symptoms and Risk of #AcuteDiarrhea, Researchers Say

Kyle J. Norton

Diarrhea is an acute condition of loose, watery stools (bowel movements). In other words, if you have loose stools three or more times in one day, you are considered to have diarrhea.
Most cases of diarrhea are acute and last for a few days. However, chronic diarrhea that lasts for a long period of time is an indication of other medical conditions, including irritable bowel disorder, or inflammatory bowel disease.

Accompanied by loose and watery stool, patients with chronic diarrhea also experience abdominal cramps and pain, fever, blood, and mucus in the stool, bloating, nausea, and the urge for a bowel movement.

The most common cause of diarrhea is an infection caused by bacteria and viruses. Some medications such as antibiotics also have been found to induce acute diarrhea.

The condition in some cases can also be induced by lactose intolerance, fructose, artificial sweeteners, and other digestive disorder such as Crohn's disease, ulcerative colitis, and celiac disease.


Acute diarrhea can be treated successfully if the cause is found. Untreated diarrhea has been found to cause complications of dehydration, particularly in children, and a weakened immune system in older adults

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and for the treatment of pains, strains, muscle aches and pains and ease back pain chronic joint pain, skin diseases, etc.

On finding a natural compound for the treatment of diarrhea, researchers examined the effects of bromelain on K88-positive enterotoxigenic Escherichia coli (K88+ ETEC), an important cause of diarrhea in young piglets.

The study included bromelain (0, 12.5, or 125 mg) orally administered to just weaned piglets for 10 days followed by the commencement of bromelain treatment, piglets were challenged with K88+ ETEC (5 x 10(10) K88ac:0149) for seven days.

Injection of 12.5 or 125 mg showed a significant effect in reducing the incidence of K88+ ETEC diarrhea and protected piglets from a life-threatening disease.
Both doses of bromelain-treated pigs also had significantly increased weight gain compared to untreated pigs.

However, bromelain only temporarily inhibited K88+ ETEC receptor activity observed by the receptor activity being regenerated 30 hours following treatment, consistent with the regeneration of new enterocytes.

In other words, both doses of bromelain can only temporarily inactivate ETEC receptors in vivo and protect against ETEC-induced diarrhea.

These results strongly suggested that bromelain treatment prevented the attachment of K88+ ETEC to piglet small intestines which inhibits the risk of K88+ ETEC pathogenesis.

Based on the finding, Dr. Chandler DS, the lead scientist wrote, "Bromelain may, therefore, be an effective prophylaxis against ETEC infection".

Taken together, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of diarrhea, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain protects piglets from diarrhea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli by Chandler DS1, Mynott TL. (PubMed)

#Herbal #Ashwagandha Significantly Reduces Myocardial Injury, According to Studies

Kyle J. Norton

The circulatory system consists of the heart, blood vessels, and blood with the function of transport of nutrients, oxygen, and hormones to cells throughout the body and removal of metabolic wastes (carbon dioxide, nitrogenous wastes).

Cardiovascular disease is a class of chronic conditions associated with the heart and blood vessels.

According to the statistics cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.

Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease risk for them, according to Jean Hailes for Women Health in the article Cardiovascular Health.

Heart disease is a class of diseases associated with interruption of blood flow in the blood vessels or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

According to the statistics, heart disease is a leading cause of death in the US. Approximately 2,000 people in the general population die of heart disease every day.

Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.

The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.

In other words, high blood pressure, high blood cholesterol, smoking, diabetes, weight, depression, and family history associated with the early onset of plaques accumulated and impeding the function of the arteries are the prevalent risk factors of cardiovascular diseases.


The World Heart Foundation, in the investigation of CVD, suggested that CVD risk factors can be classified by
* Non-modified risk factors such as age, ethnic background,....... and family history. The risk that can not be controlled

* Modified risk factors such as smoking, high blood cholesterol, and pressure, diabetes physical inactivity,.... and overweight. These types of risks can be controlled by changing lifestyle and diet.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers It is considered  anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the promotion of cardio-functioning, researchers examined the efficacy of Withania somnifera (Ws) to limit myocardial injury after ischemia and reperfusion compared to that of Vit E,

The study included Wistar rats (150-200 g) that were divided into six groups and received orally saline (sham, control group), Ws-50/kg (Ws control and treated group), and Vit E-100 mg/kg (Vit E control and treated group) respectively for 1 month.

According to the results of the experiment of Vit E and Ws treated groups that were anesthetized and subjected to 45 min occlusion of the LAD coronary artery followed by 60 min reperfusion on the 31st day,

* Postischemic reperfusion rats showed significant cardiac necrosis, depression of left ventricular functions (MAP, LVEDP, (+) and (-)LVdP/dt), and a significant fall in GSH (p < 0.01), SOD, CAT (p < 0.05).

* Postischemic reperfusion rats also demonstrated a failure in LDH and increased cardio stress markers and levels of MDA, compared to the sham group.


* In comparison tested, Ws and Vit E favorably modulated most of the hemodynamic, biochemical, and histopathological parameters though no significant restoration in GSH, mean arterial pressure VAP.

* More importantly, chronic administration of Ws on markedly augmented antioxidants (GSH, GSHPx, SOD, CAT) compared to Vit E does not stimulate the synthesis of endogenous antioxidants compared to sham.

Based on the evidence, researchers said, "Ws significantly reduced myocardial injury and emphasize the beneficial action of Ws as a cardioprotective agent".


Taken together, Ashwagandha may be considered a supplement for the treatment of myocardial injury, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment by Gupta SK1, Mohanty I, Talwar KK, Dinda A, Joshi S, Bansal P, Saxena A, Arya DS. (PubMed)

#Herbal #Ashwagandha Processes a Strong Anti-Candida Albican Activity, Researchers Reveal

Kyle J. Norton

Fungal infection is a common disease caused by an overgrowth of fungus.
In other words, it is the condition in which the immune system that protects the body against microorganisms has been overwhelmed by the overgrowth of fungus.

Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeasts, fungi, and molds that live among the gut flora in the human mouth and gastrointestinal tract.


In fact, under normal circumstances, Candida albicans does not cause harmful effects, but overgrowth results in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population.


According to the joint study, in many cases, biofilm (microorganisms with cells sticking to each other on a surface) formation gene mutations are often associated with increased Candida resistance toward antifungal agents.

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

According to the statistics provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound that processes infectious diseases, researchers examined the effects of withanamides in W. somnifera anti-fungal activity on Candida albicans (C. albicans).

The study included 9 vaginal samples collected using the sterile swap and Falcon tube by the gynecological specialists.


Based on the results of the tested analysis, withanamides incubated with C. Albicans showed a minimum inhibitory concentration (MIC) against C. Albicans, equivalent to 50 ppm to 250 ppm.


In other words, withanamides extract isolated from W. somnifera exhibited strong activity against infectious disease caused by C. Albicans.

After taking into account of con and cofounders, researchers wrote, "The results of this study showed that the antifungal activity of wind cheese against C. Albicans is good, so it can be used as a drug to treat infections caused by C. Albicans".


Taken together, Ashwagandha processes abundantly withanamides may be considered a functional herb for the treatment of infectious diseases associated with C. Albicans, pending the result of a larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antifungal effects of the extract of the Withania somnifera on Candida albicans by ereshteh Javadian 1 Zahra Sepehri 2 Saeideh Saeidi 3 Mehdi Hassanshahian. (Advanced Herbal Medicine)
(2) The Holistic approach for Prevention, controlling and Treatment of Candida Albicans Overgrowth - The Effectiveness of Antifungal products by Kyle J. Norton

#Herbal Coltsfoot"s Antioxidants process Liver-Protective Activity, Researchers Say

Kyle J. Norton

The liver is the largest internal and only organ in the human body that can regenerate itself.
The liver is the first line of detoxing defense by filtering the blood that comes from the digestive tract, before passing them to other organs and tissues in the body.

The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.

The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.

Symptoms of liver diseases include jaundice, abdominal pain, swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.

There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.

In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.


Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches obstruction in the nasal passage, etc.

In finding a potential compound that processes a liver protective effect, researchers examined the highly active photocomposition (PC-1) containing oregano (Origanum vulgare), wild thyme (Thymus serpyllum), and coltsfoot (Tussilago farfara) aerial parts, valerian (Valeriana officinalis) leaves and little-leaf linden (Tilia cordata) flowers and PC-1 extract exhibited the strongest anti-lipid peroxidation (LPO)O and antihemolytic effects.

According to the tested results, PC-1 extract activated the Nrf2/antioxidant response is more effective comapred to the extracts of other photocomposition.

Furthermore, oral administration of PC-1 extract (100-200 mg/kg) markedly protected the rat liver injury acutely or chronically against intoxication by carbon tetrachloride.

The liver protective activity of PC-1 was attributed to the activation of the levels of antioxidant enzymes in the host and the improvement of liver histology, and blood chemistry parameters.

Moreover, the osmotic fragility test (OFT) also addressed that PC-1 extract inhibited the destruction of red blood cells in carbon tetrachloride-intoxicated rats.

Based on the findings, researchers said, "These data support the strategy of in-vitro plant selection for developing efficacious tissue-protective photocomposition".

Taken together, coltsfoot may be considered a liver protective remedy, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity by Aralbaeva AN1, Mamataeva AT1, Zhaparkulova NI2, Utegalieva RS1, Khanin M3, Danilenko M4, Murzakhmetova MK. (PubMed)

#Phytochemicals #PhyticAcid Inhibits Amyloid-β (Aβ) Pathology Associated with the Onset of #Alzheimer's disease (AD), According to Stdies

Kyle J. Norton

Phytic acid, a bioactive compound found mostly in seeds and beans may have a strong and profound effect in protecting the aging brain against the onset of Alzheimer's disease (AD), some scientists suggested.
Alzheimer's disease (AD) is a neurodegenerative disease that occurs mostly in the older population characterized by progressive brain cell death that happens over time.

Alzheimer's disease worsens over time and it is fatal.

As the disease progresses, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.

In the elderly, age-related changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulated of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.

Dr. Pini L and colleagues in the study "Brain atrophy in Alzheimer's Disease and Aging" said, "Disease progression has also been associated with changes in white matter tracts. Recent studies have investigated two areas often overlooked in AD, such as the striatum and basal forebrain, reporting significant atrophy".

The results suggested the loss of white matter tracts in the striatum and basal forebrain may be the culprits that brain shrinking in the aging population.


In the analysis of the free radical, researchers suggested that free radicals overexpression cause the reduced levels of antioxidant enzymes produced by the elderly initiates the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cells damage and development of AD.

Dr. Tuppo EE, the lead author in the study of oxidative stress and AD, said, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants" and "Evidence for oxidative damage has been obtained from postmortem brain tissue as well as from living patients with Alzheimer's disease. Antioxidants such as vitamin E show promise that they may help in treating the disease.

Phytic acid (Inositol hexaphosphate) are phytochemical of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be the next potential sources of new medications for the treatment of diseases with little or no side effects.

In the finding of a novel protective treatment for AD pathology, researchers at the Oregon Health & Science University, Portland conducted an investigation to evaluate the phytic acid(inositol hexakisphosphate), a phytochemical found in food grains and a key signaling molecule in mammalian cells.

The experiment is to examine the protective and beneficial effects of phytic acid against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model.


In MC65 cells, after 48-72-hour treatment with phytic acid researchers showed that phytic acid provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by reducing the levels of calcium present, free radicals, and plaques accumulation.

Furthermore, the injection of phytic acid significantly increased brain levels of cytochrome oxidase which is found in low levels in AD patients and decreased lipid peroxidation.

The phytic acid was well tolerated with little side effects.

Additionally, in finding a composition and method for the treatment of Alzheimer's disease, researchers showed that phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination administered to a person in an amount from about 0.5 grams to about 18.75 grams per day, demonstrated a potential effect in reducing amyloid plaque development.

At the experiment, researchers also discovered that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta-amyloid proteins as are commonly seen in the brains of Alzheimer's patients.

Taken together, the phytic acid found abundant in nuts and seeds may be considered a functional supplement for the prevention of AD and an adjunct therapy combined with conventional medicine for the treatment of neurodegenerative diseases.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)
(3) Brain atrophy in Alzheimer's Disease and aging by Pini L1, Pievani M2, Bocchetta M3, Altomare D1, Bosco P2, Cavedo E4, Galluzzi S2, Marizzoni M2, Frisoni GB. (PubMed)
(4) Free radical oxidative damage and Alzheimer's disease by Tuppo EE1, Forman LJ. (PubMed)

#BN999, a Fermentation Product of #Soybean, #Blackbean, and #Greenbean Mixture Inhibits the Growth of #BreastCancer Cells

Kyle J. Norton

The woman's breast is made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a woman's breast is totally determined by the amount of fat.

Breast cancer is a medical and chronic condition characterized by abnormal cell growth either in the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Most cases of breast cancer start in the cells on the surface of the inner lining tissues of the breast before growing into a tumor by invading the deeper layers of the organ.

According to the statistics, the lifetime risk of invasive breast cancer developing is 12%.

In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer diagnosed at the early stage is close to 100%.

Epidemiologically, there are several factors that can reduce the risk of breast cancer including breastfeeding, early age at first full-term pregnancy, an increasing number of births, preeclampsia, and longer duration of breastfeeding.

Believe it or not, in a new study, published in the journal Breast Cancer Research, women who drink five cups of coffee a day or more can reduce the risk of getting certain types of breast cancer. (How many women can do that without developing nervous tension).

Dr. Davaasambuu Ganmaa, the lead scientist said, "This was a prospective cohort study with 85,987 female participants in the Nurses’ Health Study".

And, "The multivariate relative risks (RRs) of breast cancer across categories of caffeinated coffee consumption were: 1.0 for <1cup/mo (reference category), 1.01 (95% confidence interval: 0.92–1.12) for 1/mo-4.9/wk, 0.92 (0.84–1.01) for 5/wk-1.9/d, 0.93 (0.85–1.02) for 2–3.9/d, 0.92 (0.82–1.03) for ≥4 cups per day (p for trend= 0.14)".


Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belongs to the family Fabaceae, and is native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

In finding a potent compound that processes anti-cancer activity, researchers examined BN999, a fermentation product of soybean, black bean, and green bean mixture in the inhibition of the growth of human breast cancer AU565 cells.

The application of the mixed product showed a significant effect on the induction of breast cancer cells apoptosis without affecting the health of normal human cells.

Furthermore, BN999 treatment also activated the protein calpain significantly associated with adverse breast cancer-specific survival of the inflammatory breast cancer at low levels.

Moreover, BN999 also promoted caspase proteins such as caspase-8, -9, and -3 in the induction of cancer cell apoptosis through several extrinsic pathways.

Based on the findings, researchers after taking into account co and confounder wrote, "these data suggest that BN999 has the potential to be used as cancer chemoprevention or therapeutic agent".

Taken together, green beans used combined with fermentation products of soybean, the black bean may be used as an adjunct therapy for the prevention and treatment of breast cancer, pending the confirmation of a larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB. (PubMed)
(2) Coffee, tea, caffeine, and risk of breast cancer: a twenty-two-year follow-up by Davaasambuu Ganmaa,1 Walter C. Willett,1,3 Tricia Y. Li,1 Diane Feskanich,3Rob M. van Dam,1 Esther Lopez-Garcia,1 David J. Hunter,1,2 and Michelle D. Holmes. (PMC)