Kyle J. Norton
Piperine, a phytochemical alkaloid in the class of organosulfur compound may have a significant effect in blocking the energy that is necessary for cancer cells proliferation and survival, some scientists suggested.
Angiogenesis is the formation of new blood vessels in the body for healing and reproduction.
However, in invasive cancers, the formation of a new blood vessel from pre-existing vessels stimulated by cancer chemicals may be deadly to the host.
These new blood vessels provide the nutrients and fluids for cancer growth and metastasis.
Cancer is a class of diseases, characterized by cell growth irregularly that starts in the surface of the inner lining of tissue or organs. Patients at the beginning of cancer onset do not experience any symptoms.
At the later stage of the progression, the cancerous cell may travel a distance away from the primary site to infect other healthy tissues and organs. If cancer has grown large enough, it may affect other nearby healthy tissue and nerve cells, causing localized symptoms and persistently severe pain.
Angiogenesis occurs totally depends on a net balance of angiogenic factors and antiangiogenic factors, which are secreted by both tumor cells and host-infiltrating cells. If the tumor's angiogenic factors win, the new blood vessels are formed.
Some researchers suggested if we can produce a drug that cuts off the forming of the new blood vessel which supplies energy to cancer, we may cure cancer.
However, according to the epidemiological studies, antiangiogenic therapy in the inhibition of the growth of the tumor works best in combination with conventional cytotoxic chemotherapy.
Dr. Roberta WC Pang, the lead author in the investigation "Clinical Implications of Angiogenesis in Cancers" wrote, "Recently, a monoclonal antibody against vascular endothelial growth factor, which is one of the most potent angiogenic factors, has been approved for clinical use in colorectal cancer patients after a clinical trial confirmed that combining the antibody with standard chemotherapy regimen could prolong patient survival".
We can only hope that in a distant future, a single miracle drug can have an antiangiogenic potency to block off all cancers proliferation.
Piperine is a phytochemical alkaloid in the class of organosulfur compounds, found abundantly in white and black pepper, long pepper, etc.
A research team at the Dalhousie University in the investigation of piperine, a major alkaloid constituent of black pepper physiological actions in inhibition of cancer cell proliferation including the killing of cancer cells launched a study to examine the angiogenetic effect of piperine in tumor progression.
Injection of piperine inhibited the proliferation and G(1)/S transition of human umbilical vein endothelial cells (HUVECs) without causing cell death.
In vitro, piperine also inhibited HUVEC migration and tubule formation and collagen-induced angiogenic activity in rat aorta explants and breast cancer cell-induced angiogenesis in chick embryos.
Importantly, piperine inhibited phosphorylation of Ser 473 and Thr 308 residues of Akt (protein kinase B), which is a key regulator in the induction of cancer cells survival and angiogenetic proliferation.
The findings reconfirmed the function of piperine as an angiogenesis inhibitor for use in cancer treatment.
Additionally, the finding of the phytochemical which processes a strong effect in improving the function of curcumin, in the suppression of angiogenesis by inhibiting the curcumin's lack of water solubility, and relatively low bioavailability.
After multiple approaches were sought to overcome these limitations, researchers finally discovered natural curcumin analogs, namely piperine.
Piperine in the co-administration with curcumin enhanced the functions of curcumin in the suppression of angiogenesis without reducing the antitumor activity.
Taken together, piperine may be considered a functional supplement used for the prevention of cancers and an adjunction therapy by cutting the supply of energy of cancer that is life and death for cancer colonization, depending on the further study of large sample size and multi-center in human consumption.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Piperine, a dietary phytochemical, inhibits angiogenesis by Doucette CD, Hilchie AL, Liwski R, Hoskin DW.(PubMed)
(3) Clinical Implications of Angiogenesis in Cancers by Roberta WC Pang1 and Ronnie TP Poon. (PMC)
Wednesday, 4 October 2023
#Herbal #Bilberry Combined with Other Antioxidants or Conventional Medicines in theTreatment for Peyronie's Disease #PD, According to Studies
Kyle J. Norton
Peyronie's disease is a rare condition caused by plaque, that forms inside the penis, leading to a bent erect penis, depending on where the plaque is located.
Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.
Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.
Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.
Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers to find a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment which significantly increase the likelihood of therapeutic success.
By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; and three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.
According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.
Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.
In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.
The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD.
Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."
Taken together, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rationale of combination therapy with antioxidants in the medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)
Peyronie's disease is a rare condition caused by plaque, that forms inside the penis, leading to a bent erect penis, depending on where the plaque is located.
Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.
Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.
Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.
Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers to find a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment which significantly increase the likelihood of therapeutic success.
By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; and three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.
According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.
Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.
In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.
The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD.
Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."
Taken together, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rationale of combination therapy with antioxidants in the medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)
Indole-3-carbinol Cyclic Tetrameric Derivative (#CTet) Processes Anti #BreastCancer Activity, Researchers Reveal
Kyle J. Norton
Indole-3-carbinol may be the pharmaceutical target in the search for a chemo drug doe the treatment of breast cancer, some scientists suggested.
As a phytochemical in the class of Indoles, Indole-3-carbinol processes a unique function by the breaking down of the glucosinolate glucobrassicin found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, in most cases, breast cancer starts in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage, breast cancer cells caused by the alternation of DNA can travel far away from the primary site to infect other healthy tissue and organs.
Most patients at the early may have a lump when touching with no symptoms.
Patients who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.
However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.
Dr. Harvie M, the lead scientist on the breast cancer program team at the University Hospital of South Manchester NHS Foundation Trust, said, " The World Cancer Research Fund (WCRF) and American Cancer Society (ACS) cancer prevention guidelines recommend maintaining a healthy weight, undertaking at least 150 minutes of moderate-intensity exercise per week, limiting alcohol consumption, and eating a plant-based" and "Lifestyle factors appear to modify risk among high-risk women with a family history and those with typical risk of the general population".
In Postmenopause, weight control is the major factor throughout life that appears to prevent breast cancer after menopause.
Daily physical activity and reduced intake of alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.
Interestingly, in the depth discussion of the diet pattern in the risk of breast cancer, researchers do not find a direct link to breast cancer risk.
These results suggested by actively following a healthy lifestyle and moderate exercise, the risk of breast cancer can be decreased substantially.
The team on the final report said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".
According to the statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
Dr. the lead author in the research team of the cancer program in the investigation to examine the effect of indole-3-carbinol cyclic tetrameric derivative (CTet) in breast cancer cell proliferation by endoplasmic reticulum stress and autophagy-related cell death induction conducted an experiment to evaluate the synergistic activity of CTet in combination with cisplatin and doxorubicin in triple-negative breast cancer cell lines.
In MDA included -MB-231 and BT-20 triple-negative breast cancer cells, CTet in combination with both cisplatin and doxorubicin synergistically inhibits cell viability and induces autophagy.
The efficacy of the CTet and combination exerted a strong anti-cancer effect as seen in the MAP1LC3B gene that is responsible for a normal physiological process in the body in dealing with the destruction of cells.
Pre-treated with cisplatin and doxorubicin demonstrated a strong cytotoxic activity of CTet in cells in the tested cancer cell lines.
The findings reaffirmed the potential of CTet as a chemopreventive agent or chemotherapeutic in combination with standard approaches for triple-negative breast cancer.
Furthermore, indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits breast cancer cell proliferation, researchers at the University of Urbino Carlo Bo conducted an investigation to examine the antitumoral activity of a mixture of tri- and tetrameric cyclic I3C derivatives (CTr/CTet) both in vitro (MCF-7 and MDA-MB-231 breast cancer cell lines.
Observation of the application on the tested cancer cell line suggested CTr/CTet mixture inhibits breast cancer cell proliferation (IC50 = 1.3 and 1.6 μg/ml in MCF-7 and MDAMB- 231, respectively) inducing the G0/1 cell cycle phase accumulation.
The efficacy was attributed to the mixture in activating the overexpression of p21, p27 and GADD45A, which are the cell cycle regulators, nuclear translocation of FOXO3ain the induction of cell apoptosis and inhibition of Akt activity, and downregulation of estrogen receptor.in stimulating cancer cell proliferation.
Moreover, in Vivo, the tumor growth of xenotransplanted was also inhibited by reducing the function of Cyclin E and its low molecular weight which is important in the transition from G1 to the S phase of the cell cycle that determines the initiation of DNA duplication.
Taken together, Indole-3-carbinol processed apoptotic and antiproliferative activity can be considered a functional supplement for the prevention and combined with primary medicine for the treatment of breast cancer.
However, further data collection large example size, and multi-center studies performed with human consumption of the phytochemical during the course of the disease will be necessary to complete the picture of Indole-3-carbinol anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines by De Santi M1, Galluzzi L, Duranti A, Magnani M, Brandi G.(PubMed)
(2) Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies by Brandi G1, Fraternale A, Lucarini S, Paiardini M, De Santi M, Cervasi B, Paoletti MF, Galluzzi L, Duranti A, Magnani M.(PubMed).
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)
Indole-3-carbinol may be the pharmaceutical target in the search for a chemo drug doe the treatment of breast cancer, some scientists suggested.
As a phytochemical in the class of Indoles, Indole-3-carbinol processes a unique function by the breaking down of the glucosinolate glucobrassicin found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, in most cases, breast cancer starts in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage, breast cancer cells caused by the alternation of DNA can travel far away from the primary site to infect other healthy tissue and organs.
Most patients at the early may have a lump when touching with no symptoms.
Patients who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.
However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.
Dr. Harvie M, the lead scientist on the breast cancer program team at the University Hospital of South Manchester NHS Foundation Trust, said, " The World Cancer Research Fund (WCRF) and American Cancer Society (ACS) cancer prevention guidelines recommend maintaining a healthy weight, undertaking at least 150 minutes of moderate-intensity exercise per week, limiting alcohol consumption, and eating a plant-based" and "Lifestyle factors appear to modify risk among high-risk women with a family history and those with typical risk of the general population".
In Postmenopause, weight control is the major factor throughout life that appears to prevent breast cancer after menopause.
Daily physical activity and reduced intake of alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.
Interestingly, in the depth discussion of the diet pattern in the risk of breast cancer, researchers do not find a direct link to breast cancer risk.
These results suggested by actively following a healthy lifestyle and moderate exercise, the risk of breast cancer can be decreased substantially.
The team on the final report said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".
According to the statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
Dr. the lead author in the research team of the cancer program in the investigation to examine the effect of indole-3-carbinol cyclic tetrameric derivative (CTet) in breast cancer cell proliferation by endoplasmic reticulum stress and autophagy-related cell death induction conducted an experiment to evaluate the synergistic activity of CTet in combination with cisplatin and doxorubicin in triple-negative breast cancer cell lines.
In MDA included -MB-231 and BT-20 triple-negative breast cancer cells, CTet in combination with both cisplatin and doxorubicin synergistically inhibits cell viability and induces autophagy.
The efficacy of the CTet and combination exerted a strong anti-cancer effect as seen in the MAP1LC3B gene that is responsible for a normal physiological process in the body in dealing with the destruction of cells.
Pre-treated with cisplatin and doxorubicin demonstrated a strong cytotoxic activity of CTet in cells in the tested cancer cell lines.
The findings reaffirmed the potential of CTet as a chemopreventive agent or chemotherapeutic in combination with standard approaches for triple-negative breast cancer.
Furthermore, indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits breast cancer cell proliferation, researchers at the University of Urbino Carlo Bo conducted an investigation to examine the antitumoral activity of a mixture of tri- and tetrameric cyclic I3C derivatives (CTr/CTet) both in vitro (MCF-7 and MDA-MB-231 breast cancer cell lines.
Observation of the application on the tested cancer cell line suggested CTr/CTet mixture inhibits breast cancer cell proliferation (IC50 = 1.3 and 1.6 μg/ml in MCF-7 and MDAMB- 231, respectively) inducing the G0/1 cell cycle phase accumulation.
The efficacy was attributed to the mixture in activating the overexpression of p21, p27 and GADD45A, which are the cell cycle regulators, nuclear translocation of FOXO3ain the induction of cell apoptosis and inhibition of Akt activity, and downregulation of estrogen receptor.in stimulating cancer cell proliferation.
Moreover, in Vivo, the tumor growth of xenotransplanted was also inhibited by reducing the function of Cyclin E and its low molecular weight which is important in the transition from G1 to the S phase of the cell cycle that determines the initiation of DNA duplication.
Taken together, Indole-3-carbinol processed apoptotic and antiproliferative activity can be considered a functional supplement for the prevention and combined with primary medicine for the treatment of breast cancer.
However, further data collection large example size, and multi-center studies performed with human consumption of the phytochemical during the course of the disease will be necessary to complete the picture of Indole-3-carbinol anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines by De Santi M1, Galluzzi L, Duranti A, Magnani M, Brandi G.(PubMed)
(2) Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies by Brandi G1, Fraternale A, Lucarini S, Paiardini M, De Santi M, Cervasi B, Paoletti MF, Galluzzi L, Duranti A, Magnani M.(PubMed).
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)
Tuesday, 3 October 2023
#Phytochemical #Polysulfides Inhibit Pathways Associated with the Onset of #SkinCancer, Reserachers Suggest
Kyle J. Norton
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and is often detected at an early stage.
In skin cancer progression, diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer, through inhibited cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis(1).
The study by the National Taiwan University, also showed that Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracted from crushed garlic, inhibited skin cancer cell growth through involvement in G(2)/M arrest and apoptosis via activation of the p53 pathway in response to the oxidative DNA damage(2).
The Chung Shan Medical University Hospital, study also insisted that DAS protects against ultraviolet B (UVB)-induced skin tumor formation through anti photocarcinogenesis effect accompanied by the down-regulation of cell-proliferative controls, involving thymine dimer, PCNA, apoptosis, transcription factors NF-κB, and of inflammatory responses involving COX-2, PGE2, and NO, and up-regulation of p53, p21/Cip1 to prevent DNA damage and facilitate DNA repair in hairless mice(3).
References
(1) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression by Wang HC1, Pao J, Lin SY, Sheen LY. (PubMed)
(2) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis By Wang HC1, Yang JH, Hsieh SC, Sheen LY. (PubMed)
(3) Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis by Cherng JM1, Tsai KD, Perng DS, Wang JS, Wei CC, Lin JC.(PubMed)
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and is often detected at an early stage.
In skin cancer progression, diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer, through inhibited cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis(1).
The study by the National Taiwan University, also showed that Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracted from crushed garlic, inhibited skin cancer cell growth through involvement in G(2)/M arrest and apoptosis via activation of the p53 pathway in response to the oxidative DNA damage(2).
The Chung Shan Medical University Hospital, study also insisted that DAS protects against ultraviolet B (UVB)-induced skin tumor formation through anti photocarcinogenesis effect accompanied by the down-regulation of cell-proliferative controls, involving thymine dimer, PCNA, apoptosis, transcription factors NF-κB, and of inflammatory responses involving COX-2, PGE2, and NO, and up-regulation of p53, p21/Cip1 to prevent DNA damage and facilitate DNA repair in hairless mice(3).
References
(1) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression by Wang HC1, Pao J, Lin SY, Sheen LY. (PubMed)
(2) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis By Wang HC1, Yang JH, Hsieh SC, Sheen LY. (PubMed)
(3) Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis by Cherng JM1, Tsai KD, Perng DS, Wang JS, Wei CC, Lin JC.(PubMed)
#Fennel Improves the Levels of Blood #Cholesterols, According to Studies
Kyle J. Norton
Scientists may have found a natural whole food with the potential to treat hyperlipidemia without inducing any side effects, some studies suggested.
Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.
The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have been found to increase blood cholesterol, and long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.
The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding an HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".
Hyperlipidemia is a lifelong condition that is treatable.
Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".
Therefore changing the diet pattern and engaging in regular physical exercise are the fundamental
options that not only can prevent the onset of the condition, particularly in people who are at a higher risk of hyperlipidemia but also treat high blood cholesterol in patients who already have the condition.
Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The plant has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS.
In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339-induced hyperlipidemia in mice.
Mice treated with the extract at different doses display a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.
Further analysis, the application also increased the levels of HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively
The Mashhad University of Medical Sciences also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.
Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.
At the end of 3 months, blood profiles withdrawn from the women suggested
* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.
* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.
In additional differentiation of the process of the double-blind, randomized, and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.
These results indicated that the intake of foods for the treatment of conditions or diseases must be on a long-term basis. The time of 3 months may be too short for foods to exert their potential effects.
Taken together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high-fat diet in rats by Amin KA1, Nagy M(PubMed)
Scientists may have found a natural whole food with the potential to treat hyperlipidemia without inducing any side effects, some studies suggested.
Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.
The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have been found to increase blood cholesterol, and long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.
The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding an HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".
Hyperlipidemia is a lifelong condition that is treatable.
Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".
Therefore changing the diet pattern and engaging in regular physical exercise are the fundamental
options that not only can prevent the onset of the condition, particularly in people who are at a higher risk of hyperlipidemia but also treat high blood cholesterol in patients who already have the condition.
Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The plant has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS.
In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339-induced hyperlipidemia in mice.
Mice treated with the extract at different doses display a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.
Further analysis, the application also increased the levels of HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively
The Mashhad University of Medical Sciences also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.
Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.
At the end of 3 months, blood profiles withdrawn from the women suggested
* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.
* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.
In additional differentiation of the process of the double-blind, randomized, and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.
These results indicated that the intake of foods for the treatment of conditions or diseases must be on a long-term basis. The time of 3 months may be too short for foods to exert their potential effects.
Taken together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high-fat diet in rats by Amin KA1, Nagy M(PubMed)
#Broccoli Protects the Liver Against Toxicity Induced by Vincristine (VCR), Researchers Say
Kyle J. Norton
The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.
The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.
Liver disease is a broad term that includes any problems that cause the reduced function of the liver.
There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.
There is no single cause of liver disease. Researchers suggested that viruses such as hepatitis A, B, and C, long-term excessive alcohol drinking, and genetic mutation inherited from the parents are the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obese and congenital diseases such as Hemochromatosis and Wilson’s disease also are prevalent risk factors for liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol, and Illegal drugs such as cocaine.
The most common symptoms of liver disease can be felt only after more than 75% of the liver is damaged, including persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankle swelling, itching, and pale color of stool.
The most common risk factors are genetic predisposition, viruses, and long-term excessive alcohol drinking.
According to the statistics, the mortality rate infected by viral hepatitis has increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of combined therapy with Indian mustard and broccoli on rats' liver-induced hepatotoxicity by long-term vincristine (VCR)
According to the results of rats selected for the study induced liver toxicity by
* Vincristine (VCR) treated group showed signs of hepatotoxicity, including altered liver architecture and higher serum levels of liver stress markers ALT and AST.
* Vincristine (VCR) treated group also showed an impaired antioxidant potential and higher mRNA levels of IL-12 and IL-4, which are markers of apoptosis in rat livers.
In other words, VCR treatment-induced hepatocyte apoptosis by stimulating the levels of apoptotic proteins and pathways.
Most importantly, the treatment of individual administration of mustard or broccoli partially ameliorated all these responses, compared to maximum improvement in the combined therapy of both extracts.
Based on the results, researchers wrote, " Thus, the long-term administration of VCR is hepatotoxic and induces apoptosis; however, the combined therapy of both extracts mitigated these effects"
Taken altogether, broccoli may be considered a liver protective supplement, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatotoxic effect of subacute vincristine administration activates necrosis and intrinsic apoptosis in rats: protective roles of broccoli and Indian mustard by Shati AA1, Elsaid FG. (PubMed)
The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.
The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.
Liver disease is a broad term that includes any problems that cause the reduced function of the liver.
There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.
There is no single cause of liver disease. Researchers suggested that viruses such as hepatitis A, B, and C, long-term excessive alcohol drinking, and genetic mutation inherited from the parents are the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obese and congenital diseases such as Hemochromatosis and Wilson’s disease also are prevalent risk factors for liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol, and Illegal drugs such as cocaine.
The most common symptoms of liver disease can be felt only after more than 75% of the liver is damaged, including persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankle swelling, itching, and pale color of stool.
The most common risk factors are genetic predisposition, viruses, and long-term excessive alcohol drinking.
According to the statistics, the mortality rate infected by viral hepatitis has increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of combined therapy with Indian mustard and broccoli on rats' liver-induced hepatotoxicity by long-term vincristine (VCR)
According to the results of rats selected for the study induced liver toxicity by
* Vincristine (VCR) treated group showed signs of hepatotoxicity, including altered liver architecture and higher serum levels of liver stress markers ALT and AST.
* Vincristine (VCR) treated group also showed an impaired antioxidant potential and higher mRNA levels of IL-12 and IL-4, which are markers of apoptosis in rat livers.
In other words, VCR treatment-induced hepatocyte apoptosis by stimulating the levels of apoptotic proteins and pathways.
Most importantly, the treatment of individual administration of mustard or broccoli partially ameliorated all these responses, compared to maximum improvement in the combined therapy of both extracts.
Based on the results, researchers wrote, " Thus, the long-term administration of VCR is hepatotoxic and induces apoptosis; however, the combined therapy of both extracts mitigated these effects"
Taken altogether, broccoli may be considered a liver protective supplement, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatotoxic effect of subacute vincristine administration activates necrosis and intrinsic apoptosis in rats: protective roles of broccoli and Indian mustard by Shati AA1, Elsaid FG. (PubMed)
Monday, 2 October 2023
#6-Gingerol Found in #Ginger Significantly Reduces Cell Viability of Human ColonCancer Cells, Reserachers Suggest
Kyle J. Norton
Scientists may have found a kitchen spice that has the potential to treat colon cancer, according to studies.
Colon cancer is a medicinal condition associated with irregular cell growth in the colon tissues.
According to the statistics provided by Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. Cancer is the third leading cause of death behind prostate and lung cancer.
Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Colon cancer is a slow-growth cancer, therefore, most colon cancer is detected in the later stage after experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.
The 5-year survival rate of localized-stage colorectal cancer is 90%.
The cause of colon cancer is a result of the alternation of cell DNA. Researchers do not why? people with the same health conditions and family history, are susceptible to the onset of the disease, while others do not.
Although there are many factors associated with the onset of colon cancer, aging may be one of the most prevalent risks. It probably is due to the disease taken over 10 to 15 years before the patients experience some related symptoms. In other words, according to epidemiological studies, the majority of colorectal cancers occur in people older than 50.
"70% of colorectal cancer is diagnosed in patients over 65. Evaluation of the influence of age and comorbidity on survival and cause of death in a non-selected population".
And, "In colon cancer patients age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis-defining illness in the majority of patients".
The result strongly suggested that colon cancer affects mostly the aging population over 65 years of age. The simultaneous presence of two chronic diseases or conditions in elderly patients is associated with a poor survival rate.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on the finding of a bioactive compound to replace the chemo medication which induces serious side effects to cancer patients examined 6-Gingerol, a natural component of ginger, anti-colon cancer activity.
Injection of 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.
Furthermore, 6-gingerol induced significant G2/M phase arrest and had a slight influence on the sub-G1 phase in LoVo cells, according to the flow cytometric analysis and observed by the reduced levels of a protein involved cancer cell cycle.
Moreover, 6-gingerol also induced cancer cell apoptosis by elevating the functions of levels of tumor-suppressive genes and exhibiting cytotoxicity through elevated intracellular reactive oxygen species (ROS).
These results strongly suggested that 6-gingerol should be beneficial to the treatment of colon cancer, according to Dr. Lin CB and colleagues.
In order to understand more the effect of ginger on colon cancer, researchers investigated a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS) against colon cancer.
GAS exerted enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. by suppressing the enzymes involved mediation of tumor repopulation.
Importantly, GAS was also able to survive stomach acid and decompose in intestinal linings or after absorption simultaneously release ASA and [6]-gingerol.
Dr. Yingdong Zhu, the lead scientist said in the final report, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Taken altogether, ginger processed as a highly active bio-compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of colon cancer with no side effects, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest by Lin CB1, Lin CC, Tsay GJ.(PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. (Scientific Report)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
Scientists may have found a kitchen spice that has the potential to treat colon cancer, according to studies.
Colon cancer is a medicinal condition associated with irregular cell growth in the colon tissues.
According to the statistics provided by Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. Cancer is the third leading cause of death behind prostate and lung cancer.
Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Colon cancer is a slow-growth cancer, therefore, most colon cancer is detected in the later stage after experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.
The 5-year survival rate of localized-stage colorectal cancer is 90%.
The cause of colon cancer is a result of the alternation of cell DNA. Researchers do not why? people with the same health conditions and family history, are susceptible to the onset of the disease, while others do not.
Although there are many factors associated with the onset of colon cancer, aging may be one of the most prevalent risks. It probably is due to the disease taken over 10 to 15 years before the patients experience some related symptoms. In other words, according to epidemiological studies, the majority of colorectal cancers occur in people older than 50.
"70% of colorectal cancer is diagnosed in patients over 65. Evaluation of the influence of age and comorbidity on survival and cause of death in a non-selected population".
And, "In colon cancer patients age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis-defining illness in the majority of patients".
The result strongly suggested that colon cancer affects mostly the aging population over 65 years of age. The simultaneous presence of two chronic diseases or conditions in elderly patients is associated with a poor survival rate.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on the finding of a bioactive compound to replace the chemo medication which induces serious side effects to cancer patients examined 6-Gingerol, a natural component of ginger, anti-colon cancer activity.
Injection of 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.
Furthermore, 6-gingerol induced significant G2/M phase arrest and had a slight influence on the sub-G1 phase in LoVo cells, according to the flow cytometric analysis and observed by the reduced levels of a protein involved cancer cell cycle.
Moreover, 6-gingerol also induced cancer cell apoptosis by elevating the functions of levels of tumor-suppressive genes and exhibiting cytotoxicity through elevated intracellular reactive oxygen species (ROS).
These results strongly suggested that 6-gingerol should be beneficial to the treatment of colon cancer, according to Dr. Lin CB and colleagues.
In order to understand more the effect of ginger on colon cancer, researchers investigated a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS) against colon cancer.
GAS exerted enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. by suppressing the enzymes involved mediation of tumor repopulation.
Importantly, GAS was also able to survive stomach acid and decompose in intestinal linings or after absorption simultaneously release ASA and [6]-gingerol.
Dr. Yingdong Zhu, the lead scientist said in the final report, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Taken altogether, ginger processed as a highly active bio-compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of colon cancer with no side effects, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest by Lin CB1, Lin CC, Tsay GJ.(PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. (Scientific Report)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
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