Kyle J. Norton
Scientists may have found a natural whole food with the potential to treat hyperlipidemia without inducing any side effects, some studies suggested.
Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.
The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have been found to increase blood cholesterol, and long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.
The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding an HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".
Hyperlipidemia is a lifelong condition that is treatable.
Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".
Therefore changing the diet pattern and engaging in regular physical exercise are the fundamental
options that not only can prevent the onset of the condition, particularly in people who are at a higher risk of hyperlipidemia but also treat high blood cholesterol in patients who already have the condition.
Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The plant has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS.
In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339-induced hyperlipidemia in mice.
Mice treated with the extract at different doses display a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.
Further analysis, the application also increased the levels of HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively
The Mashhad University of Medical Sciences also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.
Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.
At the end of 3 months, blood profiles withdrawn from the women suggested
* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.
* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.
In additional differentiation of the process of the double-blind, randomized, and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.
These results indicated that the intake of foods for the treatment of conditions or diseases must be on a long-term basis. The time of 3 months may be too short for foods to exert their potential effects.
Taken together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high-fat diet in rats by Amin KA1, Nagy M(PubMed)
Tuesday, 3 October 2023
#Broccoli Protects the Liver Against Toxicity Induced by Vincristine (VCR), Researchers Say
Kyle J. Norton
The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.
The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.
Liver disease is a broad term that includes any problems that cause the reduced function of the liver.
There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.
There is no single cause of liver disease. Researchers suggested that viruses such as hepatitis A, B, and C, long-term excessive alcohol drinking, and genetic mutation inherited from the parents are the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obese and congenital diseases such as Hemochromatosis and Wilson’s disease also are prevalent risk factors for liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol, and Illegal drugs such as cocaine.
The most common symptoms of liver disease can be felt only after more than 75% of the liver is damaged, including persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankle swelling, itching, and pale color of stool.
The most common risk factors are genetic predisposition, viruses, and long-term excessive alcohol drinking.
According to the statistics, the mortality rate infected by viral hepatitis has increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of combined therapy with Indian mustard and broccoli on rats' liver-induced hepatotoxicity by long-term vincristine (VCR)
According to the results of rats selected for the study induced liver toxicity by
* Vincristine (VCR) treated group showed signs of hepatotoxicity, including altered liver architecture and higher serum levels of liver stress markers ALT and AST.
* Vincristine (VCR) treated group also showed an impaired antioxidant potential and higher mRNA levels of IL-12 and IL-4, which are markers of apoptosis in rat livers.
In other words, VCR treatment-induced hepatocyte apoptosis by stimulating the levels of apoptotic proteins and pathways.
Most importantly, the treatment of individual administration of mustard or broccoli partially ameliorated all these responses, compared to maximum improvement in the combined therapy of both extracts.
Based on the results, researchers wrote, " Thus, the long-term administration of VCR is hepatotoxic and induces apoptosis; however, the combined therapy of both extracts mitigated these effects"
Taken altogether, broccoli may be considered a liver protective supplement, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatotoxic effect of subacute vincristine administration activates necrosis and intrinsic apoptosis in rats: protective roles of broccoli and Indian mustard by Shati AA1, Elsaid FG. (PubMed)
The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.
The liver also produces cholesterol, a waxy substance that aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.
Liver disease is a broad term that includes any problems that cause the reduced function of the liver.
There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.
There is no single cause of liver disease. Researchers suggested that viruses such as hepatitis A, B, and C, long-term excessive alcohol drinking, and genetic mutation inherited from the parents are the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obese and congenital diseases such as Hemochromatosis and Wilson’s disease also are prevalent risk factors for liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol, and Illegal drugs such as cocaine.
The most common symptoms of liver disease can be felt only after more than 75% of the liver is damaged, including persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankle swelling, itching, and pale color of stool.
The most common risk factors are genetic predisposition, viruses, and long-term excessive alcohol drinking.
According to the statistics, the mortality rate infected by viral hepatitis has increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of liver diseases, researchers examined the effect of combined therapy with Indian mustard and broccoli on rats' liver-induced hepatotoxicity by long-term vincristine (VCR)
According to the results of rats selected for the study induced liver toxicity by
* Vincristine (VCR) treated group showed signs of hepatotoxicity, including altered liver architecture and higher serum levels of liver stress markers ALT and AST.
* Vincristine (VCR) treated group also showed an impaired antioxidant potential and higher mRNA levels of IL-12 and IL-4, which are markers of apoptosis in rat livers.
In other words, VCR treatment-induced hepatocyte apoptosis by stimulating the levels of apoptotic proteins and pathways.
Most importantly, the treatment of individual administration of mustard or broccoli partially ameliorated all these responses, compared to maximum improvement in the combined therapy of both extracts.
Based on the results, researchers wrote, " Thus, the long-term administration of VCR is hepatotoxic and induces apoptosis; however, the combined therapy of both extracts mitigated these effects"
Taken altogether, broccoli may be considered a liver protective supplement, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatotoxic effect of subacute vincristine administration activates necrosis and intrinsic apoptosis in rats: protective roles of broccoli and Indian mustard by Shati AA1, Elsaid FG. (PubMed)
Monday, 2 October 2023
#6-Gingerol Found in #Ginger Significantly Reduces Cell Viability of Human ColonCancer Cells, Reserachers Suggest
Kyle J. Norton
Scientists may have found a kitchen spice that has the potential to treat colon cancer, according to studies.
Colon cancer is a medicinal condition associated with irregular cell growth in the colon tissues.
According to the statistics provided by Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. Cancer is the third leading cause of death behind prostate and lung cancer.
Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Colon cancer is a slow-growth cancer, therefore, most colon cancer is detected in the later stage after experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.
The 5-year survival rate of localized-stage colorectal cancer is 90%.
The cause of colon cancer is a result of the alternation of cell DNA. Researchers do not why? people with the same health conditions and family history, are susceptible to the onset of the disease, while others do not.
Although there are many factors associated with the onset of colon cancer, aging may be one of the most prevalent risks. It probably is due to the disease taken over 10 to 15 years before the patients experience some related symptoms. In other words, according to epidemiological studies, the majority of colorectal cancers occur in people older than 50.
"70% of colorectal cancer is diagnosed in patients over 65. Evaluation of the influence of age and comorbidity on survival and cause of death in a non-selected population".
And, "In colon cancer patients age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis-defining illness in the majority of patients".
The result strongly suggested that colon cancer affects mostly the aging population over 65 years of age. The simultaneous presence of two chronic diseases or conditions in elderly patients is associated with a poor survival rate.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on the finding of a bioactive compound to replace the chemo medication which induces serious side effects to cancer patients examined 6-Gingerol, a natural component of ginger, anti-colon cancer activity.
Injection of 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.
Furthermore, 6-gingerol induced significant G2/M phase arrest and had a slight influence on the sub-G1 phase in LoVo cells, according to the flow cytometric analysis and observed by the reduced levels of a protein involved cancer cell cycle.
Moreover, 6-gingerol also induced cancer cell apoptosis by elevating the functions of levels of tumor-suppressive genes and exhibiting cytotoxicity through elevated intracellular reactive oxygen species (ROS).
These results strongly suggested that 6-gingerol should be beneficial to the treatment of colon cancer, according to Dr. Lin CB and colleagues.
In order to understand more the effect of ginger on colon cancer, researchers investigated a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS) against colon cancer.
GAS exerted enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. by suppressing the enzymes involved mediation of tumor repopulation.
Importantly, GAS was also able to survive stomach acid and decompose in intestinal linings or after absorption simultaneously release ASA and [6]-gingerol.
Dr. Yingdong Zhu, the lead scientist said in the final report, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Taken altogether, ginger processed as a highly active bio-compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of colon cancer with no side effects, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest by Lin CB1, Lin CC, Tsay GJ.(PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. (Scientific Report)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
Scientists may have found a kitchen spice that has the potential to treat colon cancer, according to studies.
Colon cancer is a medicinal condition associated with irregular cell growth in the colon tissues.
According to the statistics provided by Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. Cancer is the third leading cause of death behind prostate and lung cancer.
Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Colon cancer is a slow-growth cancer, therefore, most colon cancer is detected in the later stage after experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.
The 5-year survival rate of localized-stage colorectal cancer is 90%.
The cause of colon cancer is a result of the alternation of cell DNA. Researchers do not why? people with the same health conditions and family history, are susceptible to the onset of the disease, while others do not.
Although there are many factors associated with the onset of colon cancer, aging may be one of the most prevalent risks. It probably is due to the disease taken over 10 to 15 years before the patients experience some related symptoms. In other words, according to epidemiological studies, the majority of colorectal cancers occur in people older than 50.
"70% of colorectal cancer is diagnosed in patients over 65. Evaluation of the influence of age and comorbidity on survival and cause of death in a non-selected population".
And, "In colon cancer patients age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis-defining illness in the majority of patients".
The result strongly suggested that colon cancer affects mostly the aging population over 65 years of age. The simultaneous presence of two chronic diseases or conditions in elderly patients is associated with a poor survival rate.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on the finding of a bioactive compound to replace the chemo medication which induces serious side effects to cancer patients examined 6-Gingerol, a natural component of ginger, anti-colon cancer activity.
Injection of 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.
Furthermore, 6-gingerol induced significant G2/M phase arrest and had a slight influence on the sub-G1 phase in LoVo cells, according to the flow cytometric analysis and observed by the reduced levels of a protein involved cancer cell cycle.
Moreover, 6-gingerol also induced cancer cell apoptosis by elevating the functions of levels of tumor-suppressive genes and exhibiting cytotoxicity through elevated intracellular reactive oxygen species (ROS).
These results strongly suggested that 6-gingerol should be beneficial to the treatment of colon cancer, according to Dr. Lin CB and colleagues.
In order to understand more the effect of ginger on colon cancer, researchers investigated a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS) against colon cancer.
GAS exerted enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. by suppressing the enzymes involved mediation of tumor repopulation.
Importantly, GAS was also able to survive stomach acid and decompose in intestinal linings or after absorption simultaneously release ASA and [6]-gingerol.
Dr. Yingdong Zhu, the lead scientist said in the final report, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Taken altogether, ginger processed as a highly active bio-compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of colon cancer with no side effects, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest by Lin CB1, Lin CC, Tsay GJ.(PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. (Scientific Report)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
#Red Beetroot Extract (Beta vulgaris L.) Processes Anti #ProstateCancer Activity, Scientists Suggest
Kyle J. Norton
The prostate gland is a male reproductive organ warped around the urethra located in front of the rectum and just below the bladder responsible for making some of the semen that carries sperm.
The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.
Prostate cancer is a medical and chronic condition characterized by abnormal cell growth in the tissues of the prostate.
Most cases of prostate cancer start in the cells on the surface of the inner lining tissue of the prostate, before penetrating into the deeper layers to colonizing the entire prostate through cell proliferation.
At the advanced stage, prostate cancer also can spread to distant parts of the body. Most prostate cancers are slow-growing. Enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.
According to the statistics provided by the Canadian Cancer Society, in Canada, 1 in 7 men will develop prostate cancer during their lifetime, and the mortality rate of men is 1 in 27.
In other words, 1 in 4 men diagnosed with prostate cancer will die because of the disease.
The exact causes of prostate cancer are unknown, Epidemiologically, researchers do know that the below are some factors that increase the prevalence of the diseases
* Age
The risk of developing prostate cancer increases with the age of over 45
* Family history
If one of your directed family members has prostate cancer, you are twice at risk of developing it.
* Race
Prostate cancer is more likely to strike black and white in the US.
* Heredity
Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in the pathology of prostate cancer.
* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk of developing prostate cancer.
* Excessive drinking
Excessive drinking not only increases the risk of liver cancer but is also associated with a higher risk of prostate cancer as it interferes with folate metabolism.
* Enlarged prostate
Men with an enlarged prostate are at high risk of developing prostate cancer.
* Sexual transmission diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of diseases.
* Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.
However, most people with some of the risk factors have never had developed prostate cancer
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of prostate cancer, researchers examined the effect of the red beetroot extract (Beta vulgaris L.), the FDA-approved red food color E162 on the development of multi-organ tumors in experimental animals.
In human androgen-independent, human prostate cancer cells (PC-3) researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (adriamycin),
* Both doxorubicin and the beetroot extract exhibited a dose-dependent cytotoxic effect in the PC3 cancer cell lines.
* Further analysis of the cytotoxic activity of beetroot extract, researchers found that although the cytotoxicity of the beetroot extract was significantly lower compared to doxorubicin, it continued to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) at the concentration of 29 µg/ml compared to those of doxorubicin which completely inhibited the growth of the PC-3 cells in three days at the same concentration level.
* According to the chemical differentiation, the efficacy of beetroot extract anti-prostate cancer activity was attributed to the major betacyanin constituent, which plays an important role in the cytotoxic exhibition.
In other words, all phytochemicals work synergistically to exert anti-prostate cancer property, particularly, betanin, the major ingredient of betacyanin.
Taken together, betacyanins used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(2) Prostate Cancer by Kyle J. Norton
The prostate gland is a male reproductive organ warped around the urethra located in front of the rectum and just below the bladder responsible for making some of the semen that carries sperm.
The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.
Prostate cancer is a medical and chronic condition characterized by abnormal cell growth in the tissues of the prostate.
Most cases of prostate cancer start in the cells on the surface of the inner lining tissue of the prostate, before penetrating into the deeper layers to colonizing the entire prostate through cell proliferation.
At the advanced stage, prostate cancer also can spread to distant parts of the body. Most prostate cancers are slow-growing. Enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.
According to the statistics provided by the Canadian Cancer Society, in Canada, 1 in 7 men will develop prostate cancer during their lifetime, and the mortality rate of men is 1 in 27.
In other words, 1 in 4 men diagnosed with prostate cancer will die because of the disease.
The exact causes of prostate cancer are unknown, Epidemiologically, researchers do know that the below are some factors that increase the prevalence of the diseases
* Age
The risk of developing prostate cancer increases with the age of over 45
* Family history
If one of your directed family members has prostate cancer, you are twice at risk of developing it.
* Race
Prostate cancer is more likely to strike black and white in the US.
* Heredity
Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in the pathology of prostate cancer.
* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk of developing prostate cancer.
* Excessive drinking
Excessive drinking not only increases the risk of liver cancer but is also associated with a higher risk of prostate cancer as it interferes with folate metabolism.
* Enlarged prostate
Men with an enlarged prostate are at high risk of developing prostate cancer.
* Sexual transmission diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of diseases.
* Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.
However, most people with some of the risk factors have never had developed prostate cancer
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of prostate cancer, researchers examined the effect of the red beetroot extract (Beta vulgaris L.), the FDA-approved red food color E162 on the development of multi-organ tumors in experimental animals.
In human androgen-independent, human prostate cancer cells (PC-3) researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (adriamycin),
* Both doxorubicin and the beetroot extract exhibited a dose-dependent cytotoxic effect in the PC3 cancer cell lines.
* Further analysis of the cytotoxic activity of beetroot extract, researchers found that although the cytotoxicity of the beetroot extract was significantly lower compared to doxorubicin, it continued to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) at the concentration of 29 µg/ml compared to those of doxorubicin which completely inhibited the growth of the PC-3 cells in three days at the same concentration level.
* According to the chemical differentiation, the efficacy of beetroot extract anti-prostate cancer activity was attributed to the major betacyanin constituent, which plays an important role in the cytotoxic exhibition.
In other words, all phytochemicals work synergistically to exert anti-prostate cancer property, particularly, betanin, the major ingredient of betacyanin.
Taken together, betacyanins used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(2) Prostate Cancer by Kyle J. Norton
#Turmeric Inhibits Proteins Associated with the Production of Pro-Inflammatory Cytokines, According to Studies
Kyle J. Norton
Anti-inflammatory activity is the process to reduce inflammation or swelling without affecting the function of the immune system.
In the acute phase of infection, the immune first line of defense, the white blood cells, macrophages stimulates the production of blood platelets to cover the wound or cut and proinflammatory cytokines to destroy all invaders.
Most cases of acute infection are stopped at this phase and the wound is healed itself quickly.
However, if the wound is too large, then the recovery may take a longer period and through 4 overlap recovery stages. Any interruption in the overlapped recovery stage may cause the formation of scars.
Moreover, overproduction of proinflammatory cytokines that kills harmful pathogens may cause damage and death of nearby healthy cells, leading to the formation of scars, such as scar in the liver caused by hepatitis infection.
Additionally, if the immune system can not destroy the invasive pathogens in a set of times, it will compromise, leading to low-grade inflammation. Prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines can result in serious and chronic diseases.
Diseases associated with chronic inflammation induced by protein, lipid, and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.
The results have been found to cause cell death and alternation of cell DNA.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient that processes anti-inflammatory property researchers examined the effects of curcumin on inflammatory cytokines expression.
According to the tested differentiation, curcumin showed strong anti-inflammatory properties by suppressing the many pro-inflammatory cytokines and chemokines in a number of cell types and pathologic conditions.
Protein such as interleukin-18 (IL-18) associated with the generation of Th1 in pro-inflammatory responses was also inhibited by the injection curcumin in vivo.
Furthermore, in E.coli LPS stimulated murine macrophage-like cells RAW264.7 induced the activation of pro-inflammatory cytokine IL-18 was also suppressed by curcumin in a concentration-dependent manner without inducing a cytotoxic effect on murine macrophage-like cells.
Based on the findings, researchers said, " Our findings suggest that curcumin may be used as a potential therapeutic agent for the treatment of inflammatory diseases.
Taken together, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention and treatment of inflammatory diseases. pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin Suppresses the Production of Pro-inflammatory Cytokine Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-Like Cell by Renu Yadav, Babban Jee, and Sudhir Kumar Awasthi. (PMC)
Anti-inflammatory activity is the process to reduce inflammation or swelling without affecting the function of the immune system.
In the acute phase of infection, the immune first line of defense, the white blood cells, macrophages stimulates the production of blood platelets to cover the wound or cut and proinflammatory cytokines to destroy all invaders.
Most cases of acute infection are stopped at this phase and the wound is healed itself quickly.
However, if the wound is too large, then the recovery may take a longer period and through 4 overlap recovery stages. Any interruption in the overlapped recovery stage may cause the formation of scars.
Moreover, overproduction of proinflammatory cytokines that kills harmful pathogens may cause damage and death of nearby healthy cells, leading to the formation of scars, such as scar in the liver caused by hepatitis infection.
Additionally, if the immune system can not destroy the invasive pathogens in a set of times, it will compromise, leading to low-grade inflammation. Prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines can result in serious and chronic diseases.
Diseases associated with chronic inflammation induced by protein, lipid, and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.
The results have been found to cause cell death and alternation of cell DNA.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient that processes anti-inflammatory property researchers examined the effects of curcumin on inflammatory cytokines expression.
According to the tested differentiation, curcumin showed strong anti-inflammatory properties by suppressing the many pro-inflammatory cytokines and chemokines in a number of cell types and pathologic conditions.
Protein such as interleukin-18 (IL-18) associated with the generation of Th1 in pro-inflammatory responses was also inhibited by the injection curcumin in vivo.
Furthermore, in E.coli LPS stimulated murine macrophage-like cells RAW264.7 induced the activation of pro-inflammatory cytokine IL-18 was also suppressed by curcumin in a concentration-dependent manner without inducing a cytotoxic effect on murine macrophage-like cells.
Based on the findings, researchers said, " Our findings suggest that curcumin may be used as a potential therapeutic agent for the treatment of inflammatory diseases.
Taken together, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention and treatment of inflammatory diseases. pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin Suppresses the Production of Pro-inflammatory Cytokine Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-Like Cell by Renu Yadav, Babban Jee, and Sudhir Kumar Awasthi. (PMC)
#Phytochemical #Polysulfides Inhibits #ColonCancer by Reducing Cell Viability, Cell Cycle Arrest, and Apoptosis, According to Studies
Kyle J. Norton
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. The bowel is divided into 2 parts, the first part of the bowel, the small bowel, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and the breaking down of certain materials in the feces into substances some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progresses cancer in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
According to the study of the University of the Saarland, coumarin polysulfides were shown to inhibit cell growth and induce apoptosis in HCT116 colon cancer cells, by regulating the phosphatase activity of the cell cycle regulating cdc25(Cell division cycle 25, a family of dual-specificity phosphatases) family members(1).
Diallyl sulfides, another family member of Garlic-derived organosulphur compounds, also inhibited HCT116 human colon cancer cells, through reduced cell viability, cell cycle arrest, and apoptosis(2) and colo 205 human colon cancer cells through affected resistant gene expression(3)
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods, and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Reference
(1) Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells by Saidu NE1, Valente S, Bana E, Kirsch G, Bagrel D, Montenarh M.(PubMed)
(2) Diallylpolysulfides induce growth arrest and apoptosis by Busch C1, Jacob C, Anwar A, Burkholz T, Aicha Ba L, Cerella C, Diederich M, Brandt W, Wessjohann L, Montenarh M.(PubMed)
(3). Diallyl sulfide, diallyl disulfide, and diallyl trisulfide affect drug-resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo by Lai KC1, Kuo CL, Ho HC, Yang JS, Ma CY, Lu HF, Huang HY, Chueh FS, Yu CC, Chung JG.(PubMed)
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. The bowel is divided into 2 parts, the first part of the bowel, the small bowel, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and the breaking down of certain materials in the feces into substances some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progresses cancer in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
According to the study of the University of the Saarland, coumarin polysulfides were shown to inhibit cell growth and induce apoptosis in HCT116 colon cancer cells, by regulating the phosphatase activity of the cell cycle regulating cdc25(Cell division cycle 25, a family of dual-specificity phosphatases) family members(1).
Diallyl sulfides, another family member of Garlic-derived organosulphur compounds, also inhibited HCT116 human colon cancer cells, through reduced cell viability, cell cycle arrest, and apoptosis(2) and colo 205 human colon cancer cells through affected resistant gene expression(3)
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods, and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Reference
(1) Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells by Saidu NE1, Valente S, Bana E, Kirsch G, Bagrel D, Montenarh M.(PubMed)
(2) Diallylpolysulfides induce growth arrest and apoptosis by Busch C1, Jacob C, Anwar A, Burkholz T, Aicha Ba L, Cerella C, Diederich M, Brandt W, Wessjohann L, Montenarh M.(PubMed)
(3). Diallyl sulfide, diallyl disulfide, and diallyl trisulfide affect drug-resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo by Lai KC1, Kuo CL, Ho HC, Yang JS, Ma CY, Lu HF, Huang HY, Chueh FS, Yu CC, Chung JG.(PubMed)
#Phytochemical #Polysulfides Exhibit Anti #BreastCancer Proliferative Activity, Researchers Reveal
Kyle J. Norton
Polysulfide, a bioactive and organic phytochemical found most in garlic and onion may have a strong effect in reducing the risk and treatment of breast cancer, some studies found.
Breast cancer is a medical condition characterized by irregular cell growth in the breast tissue. At the early stage, most breast cancer starts in the cell with alternated DNA on the surface of the breast's inner linings.
At the advanced stage, the breast cancer cell can travel a distance away from the original site to affect other healthy tissues and organs through the circulation of lymph and blood.
The exact causes of the alteration of breast cells' DNA are unknown. However, researchers do know that the genetic preposition of gene BRCA 1 and 2 are one of the major risk factors which are associated with 8% of breast cancer onset.
Unfortunately, women who carry the mutated genes BRCA 1 and 2 have a 60% increased risk of breast cancer.
Dr. Angèle S and colleagues in examining gene implication in the risk of breast cancer wrote, "Loss of heterozygosity in the region of the ATM gene on chromosome 11, has been found in about 40% of sporadic breast tumors. However, screening for ATM mutations in sporadic breast cancer cases, showing or no adverse effects to radiotherapy, has not revealed the magnitude of involvement of the ATM gene expected".
Furthermore, in the concerns of the unprecedented rise in obesity, and the health impact in elevated risk of chronic diseases, researchers at the joint study led by the Braman Family Breast Cancer Institute at Sylvester Comprehensive Cancer Center launched an investigation of "Obesity and adverse breast cancer risk and outcome".
The results were published in the medical literature online of the US National Library of Medicine and the National Institutes of Health.
In the final report, researchers wrote, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages." and "increased physical activity is associated with lower breast cancer risk and better outcomes. The effects of recent lifestyle interventions to decrease sex steroids, insulin/insulin‐like growth factor‐1 pathway activation, and inflammatory biomarkers associated with worse breast cancer outcomes".
According to the statistics, in 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2).
These results suggested, that following a healthy diet that has strong activity in promoting weight loss and a lifestyle with moderate exercise are the best methods to decrease the risk of breast cancer.
Early diagnosis with self-examination also reduced the risk of breast cancer onset and increased the rate of survival,
The 5 years survival rate of the early stage of breast cancer is 100%.
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
In the study to reaffirm the effects of organosulfur compounds (OSCs), naturally found in Allium vegetables, in suppressing the proliferation of various tumor cells, researchers at the Laboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique conducted an experiment to find the specific molecular mechanisms involved in OSC.
Polysulfides isolated from the organosulfur compounds demonstrated significant breast cancer antiproliferation.
The phytochemical also exerted an inhibitory activity through cell cycle arrest by targeting the cell division cycle (Cdc) 25 phosphatases which are crucial enzymes of the cell cycle.
The growth of both sensitive (MCF-7) and resistant (Vcr-R) human breast carcinoma cells was significantly decreased by polysulfides.
Furthermore, in the identification of agents that are non-toxic but can delay the onset and/or progression of breast cancer, by differentiating polysulfides, the garlic-derived organosulfur compounds (OSCs), a promising cancer chemopreventive constituent of garlic, on the growth of two cell lines respectively, MCF-7 human breast cancer cells and nontumorigenic MCF-12a mammary epithelial cells.
Application of garlic constituent polysulfides suppressed the viability of cultured MCF-7 and MCF-12a cells respectively by decreasing the percent of cells in G(2)/M and inducing apoptotic cell death.
Polysulfide-induced apoptosis was markedly elevated in MCF-7 cells compared with MCF-12a cells and this was correlated with elevated levels of cyclin B1, a program cell mediator.
Moreover, the application of the garlic-isolated compound also increased the expression of apoptotic and decreased the expression of proliferative enzymes and proteins in MCF-7 cells.
The results suggested that polysulfides displayed a strong anti-breast cancer effect through apoptotic and antiproliferative pathways.
Taken altogether, polysulfides including a class of chemical compounds containing chains of sulfur atoms may be considered a functional bioactive compound for the prevention of breast cancer and an adjunct supplement combined with primary treatment for breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases by Viry E1, Anwar A, Kirsch G, Jacob C, Diederich M, Bagrel D.(PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) The ATM gene and breast cancer: is it really a risk factor? by Angèle S1, Hall J.(PubMed)
(4) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, PhD, 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, PhD. (PMC)
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