Kyle J. Norton
Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.
At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including unintended weight loss, loss of appetite, fatigue, and tiredness, and gastrointestinal problems.
Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Metastasis is the process to induce the development of secondary malignant growths at a distance from primary cancer.
Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.
According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the prevention of metastasis in cancer, researchers examined the effects of Furanodiene, a bioactive compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin) on tumor metastatic activities.
According to the tested differentiation, low concentrations (5-25μM) of furanodiene inhibited adhesion, migration, and invasion of breast cancer cells, without inducing cytotoxicity, apoptosis and cell cycle arrest.
Furthermore, furanodiene also regulated the parameters such as the integrin αV expression, β-catenin expression, associated with the cell survival, migration, proliferation, differentiation, angiogenesis, and remodeling of the extracellular matrix in the modulation of the tumor metastasis process.
In MDA-MB-231 cells, furanodiene modulated the matrix metalloproteinase 9 (MMP-9) involved in tumor metastasis and cancer markers.
Based on the results Dr. Zhong Z, the lead scientist said, "furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer".
Taken together, turmeric processed with a high amount of bioactive compound furanodiene may be considered a supplement for the prevention of tumor metastasis, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro by Zhong Z1, Tan W1, Chen X2, Wang Y. (PubMed)
Thursday, 17 August 2023
#Lycopene Exerts Antioxidant Property Against the Initiation of Free Radical Chain Reaction, and Chelating Activity Against Chemical Toxins, Researchers Find
Kyle J. Norton
Natural toxins are toxic chemicals produced by living organisms with the aim to protect themselves from predators. Therefore, these types of toxins do not cause harm to the host but can be very deadly to other organisms if they are consumed.
The most common types of natural toxins produced by plants are alkaloids such as pyrrolizidine alkaloids and glycoalkaloids, cyanogenic glycosides, lectins, saponins, and antinutrients.
Chemical toxins are chemicals or substances that not only are harmful to the environment but a hazard to human health if inhaled, ingested, or absorbed through the skin.
The most common types of chemical toxins are inorganic compounds such as mercury and carbon monoxide, and organic compounds, such as methyl alcohol.
The Institute of Natural Medicine suggested that exposure to chemical and natural toxins may cause* Enzyme dysfunction, including antioxidant enzymes that prevent the free-radical damage that causes damage to protein, lipid, and cell DNA.
* Reduced mineral absorption that can induce bone disease.
* Damage to the organs, particularly in the detox organs, such as the liver and kidney
* Damage cells' DNA and modify genetic expressions of the host that initiates the onset of cancer.
* Alternation of the body's hormones by inducing, inhibiting, mimicking, and blocking hormone production.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to protect the body against environmental, occupational, and therapeutic toxins, researchers examined the lycopene anti-toxic agent's activity.
High intake of lycopene administration has been effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides.
Phytochemical carotenoids processed by abundantly bioactive compound lycopene have also been found to process antioxidative activity against long-term overexpression of free radicals, antiapoptotic activity against cancer cells, radical scavenging activity against the initiation of free radical chain reaction, and chelating activity against chemical toxins.
Furthermore, lycopene also played a critical role in the modulation of inflammatory pathways that facilitate the onset of protein, lipid, and cellular DNA damage.
Based on the results, researchers said, " This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants".
Taken together, lycopene found in carotenoids may be considered supplements for the prevention and treatment of diseases associated with chemical and natural toxins, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of lycopene against chemical and natural toxins: A review by Hedayati N1, Naeini MB2, Nezami A1, Hosseinzadeh H1,3, Wallace Hayes A4,5, Hosseini S1, Imenshahidi M1,3, Karimi G. (PubMed)
(2) How Toxins Cause Disease by The Institute of Natural Medicine
Natural toxins are toxic chemicals produced by living organisms with the aim to protect themselves from predators. Therefore, these types of toxins do not cause harm to the host but can be very deadly to other organisms if they are consumed.
The most common types of natural toxins produced by plants are alkaloids such as pyrrolizidine alkaloids and glycoalkaloids, cyanogenic glycosides, lectins, saponins, and antinutrients.
Chemical toxins are chemicals or substances that not only are harmful to the environment but a hazard to human health if inhaled, ingested, or absorbed through the skin.
The most common types of chemical toxins are inorganic compounds such as mercury and carbon monoxide, and organic compounds, such as methyl alcohol.
The Institute of Natural Medicine suggested that exposure to chemical and natural toxins may cause* Enzyme dysfunction, including antioxidant enzymes that prevent the free-radical damage that causes damage to protein, lipid, and cell DNA.
* Reduced mineral absorption that can induce bone disease.
* Damage to the organs, particularly in the detox organs, such as the liver and kidney
* Damage cells' DNA and modify genetic expressions of the host that initiates the onset of cancer.
* Alternation of the body's hormones by inducing, inhibiting, mimicking, and blocking hormone production.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to protect the body against environmental, occupational, and therapeutic toxins, researchers examined the lycopene anti-toxic agent's activity.
High intake of lycopene administration has been effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides.
Phytochemical carotenoids processed by abundantly bioactive compound lycopene have also been found to process antioxidative activity against long-term overexpression of free radicals, antiapoptotic activity against cancer cells, radical scavenging activity against the initiation of free radical chain reaction, and chelating activity against chemical toxins.
Furthermore, lycopene also played a critical role in the modulation of inflammatory pathways that facilitate the onset of protein, lipid, and cellular DNA damage.
Based on the results, researchers said, " This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants".
Taken together, lycopene found in carotenoids may be considered supplements for the prevention and treatment of diseases associated with chemical and natural toxins, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of lycopene against chemical and natural toxins: A review by Hedayati N1, Naeini MB2, Nezami A1, Hosseinzadeh H1,3, Wallace Hayes A4,5, Hosseini S1, Imenshahidi M1,3, Karimi G. (PubMed)
(2) How Toxins Cause Disease by The Institute of Natural Medicine
#CranberryJuices Inhibits Parameters and Markers Associated with the Risk of CardiovascularDisease, According to Studies
Kyle J. Norton
Cholesterol produced by the liver and from dietary sources is needed for the cell to build strong membranes, produce steroid hormone, bile acids, and vitamin D, and aid digestive functioning.
Most people with high blood cholesterol at the early do not experience any symptoms, however, as the levels of blood cholesterol continue to grow, at some points, patients may experience heart-related symptoms, including chest pain or angina, pain while walking caused by reduced blood flow to the legs.
In serious cases, elevated blood cholesterol can also induce symptoms of stroke and heart attack.
There are 2 types of blood cholesterol
* Low-density lipoprotein (LDL) also is known as “bad cholesterol”. Bad cholesterol is a major cause of plaque build-up in the arteries and a leading cause of coronary heart disease.
*High-density lipoprotein (HDL) is known as “good cholesterol”. HDL removes LDL cholesterol from your arteries back to the liver.
The healthy ratio of blood cholesterol is 4 LDL)/ 1HLD
Besides a high-fat diet, certain risk factors such as a family history of high cholesterol, being overweight or obese, physical inactivity, excessive alcohol intake, smoking and some health conditions including diabetes, kidney disease, and liver disease have been found to increase the risk of high blood cholesterol.
Epidemiological studies also suggested that a high level of blood cholesterol is associated with an increased risk of cardiovascular disease.
The endothelium is a thin membrane that lines the inside of the heart and blood vessels. The endothelium cells process an essential function in controlling vascular relaxation and contraction.
Furthermore, the endothelium cells also control enzymes associated with blood clotting, immune function, and platelet adhesion.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of prostate diseases, researchers examined the effect of chronic cranberry juice consumption on cholesterol profiles and vascular functions in an estrogen-deficient animal model.
The study included ovariectomized rats that were treated daily with commercial cranberry juice at 7 mg/kg for 8 weeks, and a dosage comparable to recent clinical studies.
According to the tested analysis, cranberry juice consumption reduced circulating levels of total cholesterol, triacylglycerols, HDL, nHDL, and nHDL/HDL ratio.
Furthermore, cranberry juice consumption improved endothelium-dependent relaxation in the aorta of ovariectomized rats by restoring p-eNOS level (endothelial nitric oxide synthase.
Overexpression of renin-angiotensin system markers (angiotensin-converting enzyme, angiotensin II, and angiotensin II type 1 receptor) associated with blood pressure was also inhibited by commercial cranberry juice.
Furthermore, commercial cranberry juice also normalizes the elevated NAD(P)H oxidase expression and oxidative stress involved in the increased levels of ROS.
Based on the findings, researchers concluded. " the novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles".
Taken together, cranberry may be considered a remedy for the prevention and treatment of cardiovascular disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats by Yung LM1, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Vanhoutte PM, Yao X, Huang Y. (PubMed)
Cholesterol produced by the liver and from dietary sources is needed for the cell to build strong membranes, produce steroid hormone, bile acids, and vitamin D, and aid digestive functioning.
Most people with high blood cholesterol at the early do not experience any symptoms, however, as the levels of blood cholesterol continue to grow, at some points, patients may experience heart-related symptoms, including chest pain or angina, pain while walking caused by reduced blood flow to the legs.
In serious cases, elevated blood cholesterol can also induce symptoms of stroke and heart attack.
There are 2 types of blood cholesterol
* Low-density lipoprotein (LDL) also is known as “bad cholesterol”. Bad cholesterol is a major cause of plaque build-up in the arteries and a leading cause of coronary heart disease.
*High-density lipoprotein (HDL) is known as “good cholesterol”. HDL removes LDL cholesterol from your arteries back to the liver.
The healthy ratio of blood cholesterol is 4 LDL)/ 1HLD
Besides a high-fat diet, certain risk factors such as a family history of high cholesterol, being overweight or obese, physical inactivity, excessive alcohol intake, smoking and some health conditions including diabetes, kidney disease, and liver disease have been found to increase the risk of high blood cholesterol.
Epidemiological studies also suggested that a high level of blood cholesterol is associated with an increased risk of cardiovascular disease.
The endothelium is a thin membrane that lines the inside of the heart and blood vessels. The endothelium cells process an essential function in controlling vascular relaxation and contraction.
Furthermore, the endothelium cells also control enzymes associated with blood clotting, immune function, and platelet adhesion.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of prostate diseases, researchers examined the effect of chronic cranberry juice consumption on cholesterol profiles and vascular functions in an estrogen-deficient animal model.
The study included ovariectomized rats that were treated daily with commercial cranberry juice at 7 mg/kg for 8 weeks, and a dosage comparable to recent clinical studies.
According to the tested analysis, cranberry juice consumption reduced circulating levels of total cholesterol, triacylglycerols, HDL, nHDL, and nHDL/HDL ratio.
Furthermore, cranberry juice consumption improved endothelium-dependent relaxation in the aorta of ovariectomized rats by restoring p-eNOS level (endothelial nitric oxide synthase.
Overexpression of renin-angiotensin system markers (angiotensin-converting enzyme, angiotensin II, and angiotensin II type 1 receptor) associated with blood pressure was also inhibited by commercial cranberry juice.
Furthermore, commercial cranberry juice also normalizes the elevated NAD(P)H oxidase expression and oxidative stress involved in the increased levels of ROS.
Based on the findings, researchers concluded. " the novel cardiovascular benefits of cranberry juice consumption in improving both vascular functions and cholesterol profiles".
Taken together, cranberry may be considered a remedy for the prevention and treatment of cardiovascular disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats by Yung LM1, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Vanhoutte PM, Yao X, Huang Y. (PubMed)
#Phytochemical #Sinigrin Stimulates a Protein and Gene Associated with A Reduced Risk of #LiverCancer, Researchers Say
Kyle J. Norton
Sinigrin may be the next-generation natural and bioactive compound processed an antiproliferative activity against the progression of cancer, according to studies.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
From the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
The programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dr. Albanes D, in the study of cell proliferation as a major risk factor for cancer, said, "Caloric restriction strongly inhibits the development of neoplasia in rodents, and there is evidence of a positive relationship between cancer and body weight in humans".
And, "A recent link between adult stature and cancer incidence similarly implicates a lasting effect for growth and possibly for early nutrition in carcinogenesis. It is postulated that cancer risk is proportional to the number of proliferating cells, which in turn depends on both the number of cells and the rate of cell division within the tissue".
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers on finding a bioactive compound for the treatment of liver cancer, one of the leading causes of cancer death worldwide. investigated the anti-proliferative activity of sinigrin, the major ingredient present in Brassica nigra.
In a model of carcinogen-induced hepatotoxicity in rats, the selected animals were orally administered with sinigrin on a daily basis for three months before sacrifice.
During the experiment, the injection of sinigrin significantly inhibited the proliferation of liver tumor cells, observed by the reduction of the number of surface tumors in the rat liver.
Sinigrin induced apoptosis of liver cancer cells by exhibiting the expression of a protein associated with tumor suppression in the host rats, namely, the p53.
Furthermore, the application of sinigrin-induced cancer apoptosis by stimulating the production of a protein involved in cell death programming and a gene involved in cellular differentiation.
Interestingly, in the additional analysis of the sinigrin anti-liver cancer activity, researchers showed that the bioactive compound not only inhibits cancer cells from proliferation through cell cycle arrest but also restores liver function without inducing liver toxicity.
The results strongly suggested that sinigrin processed significant anti-liver cancer properties via several genes and pathways.
Dr. Jie M, the lead scientist wrote in the final report, "Sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlights the potential of sinigrin as an anti-cancer agent for liver cancer".
Taken altogether, sinigrin found in Brassica nigra may be considered a functional supplement for the prevention and treatment of liver cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(2) Are cell number and cell proliferation risk factors for cancer? by Albanes D1, Winick M. (PubMed)
Sinigrin may be the next-generation natural and bioactive compound processed an antiproliferative activity against the progression of cancer, according to studies.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
From the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
The programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In phytochemicals, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dr. Albanes D, in the study of cell proliferation as a major risk factor for cancer, said, "Caloric restriction strongly inhibits the development of neoplasia in rodents, and there is evidence of a positive relationship between cancer and body weight in humans".
And, "A recent link between adult stature and cancer incidence similarly implicates a lasting effect for growth and possibly for early nutrition in carcinogenesis. It is postulated that cancer risk is proportional to the number of proliferating cells, which in turn depends on both the number of cells and the rate of cell division within the tissue".
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers on finding a bioactive compound for the treatment of liver cancer, one of the leading causes of cancer death worldwide. investigated the anti-proliferative activity of sinigrin, the major ingredient present in Brassica nigra.
In a model of carcinogen-induced hepatotoxicity in rats, the selected animals were orally administered with sinigrin on a daily basis for three months before sacrifice.
During the experiment, the injection of sinigrin significantly inhibited the proliferation of liver tumor cells, observed by the reduction of the number of surface tumors in the rat liver.
Sinigrin induced apoptosis of liver cancer cells by exhibiting the expression of a protein associated with tumor suppression in the host rats, namely, the p53.
Furthermore, the application of sinigrin-induced cancer apoptosis by stimulating the production of a protein involved in cell death programming and a gene involved in cellular differentiation.
Interestingly, in the additional analysis of the sinigrin anti-liver cancer activity, researchers showed that the bioactive compound not only inhibits cancer cells from proliferation through cell cycle arrest but also restores liver function without inducing liver toxicity.
The results strongly suggested that sinigrin processed significant anti-liver cancer properties via several genes and pathways.
Dr. Jie M, the lead scientist wrote in the final report, "Sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlights the potential of sinigrin as an anti-cancer agent for liver cancer".
Taken altogether, sinigrin found in Brassica nigra may be considered a functional supplement for the prevention and treatment of liver cancer, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(2) Are cell number and cell proliferation risk factors for cancer? by Albanes D1, Winick M. (PubMed)
#Phytochemical 3,3'-#Diindolylmethane Inhibits #GastrointestinalCancer by Acting Upon Several Cellular and Molecular Processes
Kyle J. Norton
Scientists may have found a bioactive ingredient for the treatment of gastrointestinal cancer with no side effects, according to studies.
Gastrointestinal (GI) cancer is a group of cancers, affecting the digestive system, including esophagus, gallbladder & biliary tract, liver, pancreas, stomach, small intestine, bowel, and anus
The digestive system consists of the gastrointestinal tract and other parts of the accessory organs of digestion including the tongue, salivary glands, pancreas, liver, and gallbladder), involved in the function of breaking down food into smaller and smaller components then absorbed before passing them as nutrients and fluids to the body.
Most cases of gastrointestinal cancer start in the cells on the surface of the inner lining tissues, depending on the location of the affected organs.
At the early stage, most patients are asymptomatic due to the small size of the tumor. However, at the later stage, after penetrating into deeper layers of the organ, cancer cells can travel through blood and fluids circulation to infect other healthy tissues or organs, leading to secondary metastasis.
At this stage, besides sharing the general symptoms of other types of cancer, gastrointestinal cancer also cause symptoms of severe pain and bleeding due to the overgrowth of tumor size that has suppressed the nearby blood vessels and nerve cells.
The exact causes of gastrointestinal cancer are not identified. However, genetic preposition, unhealthy lifestyle and medical conditions are some of the prevalent risks of the disease.
Some researchers suggested that a poor diet may have a strong implication on the incidence of gastrointestinal cancer.
Dr. Reilly T. Enos, the lead scientist said, "High-fat-diet (HFD) consumption is associated with colon cancer risk".
And, "HFDs with the highest SF content had the greatest concentration of Muc2. Our data suggest that high dietary SF is protective in the AOM/DSS model of colon cancer, which may be due, at least in part, to the ability of SF to maintain intestinal barrier integrity through increased colonic Muc2".
With an aim to find a natural compound for the treatment of gastrointestinal cancers, researchers examined the 3,3'-Diindolylmethane (DIM) activity against effective gastrointestinal cancers.
In vivo and vitro, injection of the DIM acted upon several cellular and molecular processes in gastrointestinal cancer cells.
In cancer cells apoptosis, DIM initiated production reactive oxygen species (ROS) in generating stress, triggering DNA damage by increasing the cytotoxicity.
In angiogenesis, DIM inhibited the protein associated with the generation of a new blood vessel for cell survival and proliferation.
In cell cycle regulation, DIM deactivated the expression of protein kinases which play critical roles in cancer cell division.
Furthermore, DIM triggers cellular endoplasmic reticulum (ER) stress and apoptosis within the cancer cells.
In autophagy, DIM inhibited autophagy that leads to cell death.
In metastasis, DIM inhibited the growth of human cancer cells by interfering with multiple signaling pathways, involved restraining invasion, migration, and promoting apoptosis.
Furthermore, DIM used combined with conventional chemo drugs or therapeutic chemicals increased the efficacy of other drugs for the treatment of gastrointestinal cancer.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of gastrointestinal cancers, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer by Kim SM. (PubMed)
Scientists may have found a bioactive ingredient for the treatment of gastrointestinal cancer with no side effects, according to studies.
Gastrointestinal (GI) cancer is a group of cancers, affecting the digestive system, including esophagus, gallbladder & biliary tract, liver, pancreas, stomach, small intestine, bowel, and anus
The digestive system consists of the gastrointestinal tract and other parts of the accessory organs of digestion including the tongue, salivary glands, pancreas, liver, and gallbladder), involved in the function of breaking down food into smaller and smaller components then absorbed before passing them as nutrients and fluids to the body.
Most cases of gastrointestinal cancer start in the cells on the surface of the inner lining tissues, depending on the location of the affected organs.
At the early stage, most patients are asymptomatic due to the small size of the tumor. However, at the later stage, after penetrating into deeper layers of the organ, cancer cells can travel through blood and fluids circulation to infect other healthy tissues or organs, leading to secondary metastasis.
At this stage, besides sharing the general symptoms of other types of cancer, gastrointestinal cancer also cause symptoms of severe pain and bleeding due to the overgrowth of tumor size that has suppressed the nearby blood vessels and nerve cells.
The exact causes of gastrointestinal cancer are not identified. However, genetic preposition, unhealthy lifestyle and medical conditions are some of the prevalent risks of the disease.
Some researchers suggested that a poor diet may have a strong implication on the incidence of gastrointestinal cancer.
Dr. Reilly T. Enos, the lead scientist said, "High-fat-diet (HFD) consumption is associated with colon cancer risk".
And, "HFDs with the highest SF content had the greatest concentration of Muc2. Our data suggest that high dietary SF is protective in the AOM/DSS model of colon cancer, which may be due, at least in part, to the ability of SF to maintain intestinal barrier integrity through increased colonic Muc2".
With an aim to find a natural compound for the treatment of gastrointestinal cancers, researchers examined the 3,3'-Diindolylmethane (DIM) activity against effective gastrointestinal cancers.
In vivo and vitro, injection of the DIM acted upon several cellular and molecular processes in gastrointestinal cancer cells.
In cancer cells apoptosis, DIM initiated production reactive oxygen species (ROS) in generating stress, triggering DNA damage by increasing the cytotoxicity.
In angiogenesis, DIM inhibited the protein associated with the generation of a new blood vessel for cell survival and proliferation.
In cell cycle regulation, DIM deactivated the expression of protein kinases which play critical roles in cancer cell division.
Furthermore, DIM triggers cellular endoplasmic reticulum (ER) stress and apoptosis within the cancer cells.
In autophagy, DIM inhibited autophagy that leads to cell death.
In metastasis, DIM inhibited the growth of human cancer cells by interfering with multiple signaling pathways, involved restraining invasion, migration, and promoting apoptosis.
Furthermore, DIM used combined with conventional chemo drugs or therapeutic chemicals increased the efficacy of other drugs for the treatment of gastrointestinal cancer.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of gastrointestinal cancers, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer by Kim SM. (PubMed)
#FermentedCucumbers Exhibit Probiotic Properties in the Improvement of the Digestive Health, Researchers Find
Kyle J. Norton
Scientists may have found a bioactive ingredient for the prevention and treatment of neurodegeneration with no side effects, according to studies.
Probiotics are live bacteria and yeasts that play an essential role in the improvement of digestive functioning.
In other words, probiotics balanced the ratio of the gut microbiota by improving the levels of healthy organisms in the gut, particularly in people who are taking antibiotics, leading to the optimization of the digestive system in the absorption of nutrients for the body's needs such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function.
Where gut microbiota is the complex community of microorganisms that live in our gastrointestinal tracts.
Microbial imbalance or dysbiosis-induced intestinal inflammation as a result of overexpression of bad organisms in the gut has been found to utilize a complex arsenal of virulence factors to colonize and persist in the intestine, implicating the development of intestinal diseases.
Some virulence factors such as the genotoxin colibactin, produced by overexpression of bad bacteria in the gut were found to promote colorectal cancer and chronic intestinal inflammatory diseases.
Dr. Yu-Jie Zhang, the lead scientist in the examined the importance of gut bacteria on Human Health wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells".
And, " they (imbalanced ratio of gut microbiota) can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find potential and natural compounds for the improvement of digestive health, researchers investigation the probiotic activity of cucumber.
According to the novel strain of lactic acid bacterium isolated from fermented cucumber, fermented carbohydrates such as sucrose, dextrose, and arabinose showed a significant gastroprotective effect against antibiotics, including ciprofloxacin, kanamycin, and vancomycin.
Furthermore, the isolate displayed potential probiotic properties in the improvement of the digestive health observed by hydrophobicity, autoaggregation, coaggregation, and in vitro cell adhesion ability.
Moreover, the isolate also exhibited resistance against bad bacteria and simulated gastric juice at pH 3.0.
Based on the findings researchers suggested that a novel strain of lactic acid bacterium isolated from fermented cucumber protected the digestive tract against the injection of antibiotics, inhibited the production of bad bacteria such as gram-positive bacterial and utilized the effects of prebiotics such as inulin and raffinose.
Dr. Shukla R, the lead scientist said, " These results indicate both probiotic property and the glucan-sucrase-producing ability of P. pentosaceus CRAG3".
In vitro, in the evaluation of the probiotic potentials of three Bacillus strains 437F, 1630F, and 1020G obtained from the traditional pickle researchers found that
* All strains only showed high acid, and bile tolerance but also exhibited antagonistic activity against various pathogens.
* All strains exhibited antioxidant activity, auto- and co-aggregation ability and surface hydrophobicity and attachment capacity against the Caco-2 cells were similar to those of well-known probiotic strains.
* All strains are safe without causing harm to healthy colon cells.
Based on the findings, researchers said, "With respect to their characteristics and safety aspect, these Bacillus species may have the potential to consider as probiotics for animal and/or human applications".
Taken altogether, cucumber may be considered supplements for the protection of digestive functioning, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Probiotic Potential of Pediococcus pentosaceus CRAG3: A New Isolate from Fermented Cucumber by Shukla R1, Goyal A. (PubMed)
(2) Three novel Bacillus strains from a traditional lacto-fermented pickle as potential probiotics by Talebi S1, Makhdoumi A1, Bahreini M1, Matin MM1,2, Moradi HS. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li1. (PubMed)
Scientists may have found a bioactive ingredient for the prevention and treatment of neurodegeneration with no side effects, according to studies.
Probiotics are live bacteria and yeasts that play an essential role in the improvement of digestive functioning.
In other words, probiotics balanced the ratio of the gut microbiota by improving the levels of healthy organisms in the gut, particularly in people who are taking antibiotics, leading to the optimization of the digestive system in the absorption of nutrients for the body's needs such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function.
Where gut microbiota is the complex community of microorganisms that live in our gastrointestinal tracts.
Microbial imbalance or dysbiosis-induced intestinal inflammation as a result of overexpression of bad organisms in the gut has been found to utilize a complex arsenal of virulence factors to colonize and persist in the intestine, implicating the development of intestinal diseases.
Some virulence factors such as the genotoxin colibactin, produced by overexpression of bad bacteria in the gut were found to promote colorectal cancer and chronic intestinal inflammatory diseases.
Dr. Yu-Jie Zhang, the lead scientist in the examined the importance of gut bacteria on Human Health wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells".
And, " they (imbalanced ratio of gut microbiota) can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find potential and natural compounds for the improvement of digestive health, researchers investigation the probiotic activity of cucumber.
According to the novel strain of lactic acid bacterium isolated from fermented cucumber, fermented carbohydrates such as sucrose, dextrose, and arabinose showed a significant gastroprotective effect against antibiotics, including ciprofloxacin, kanamycin, and vancomycin.
Furthermore, the isolate displayed potential probiotic properties in the improvement of the digestive health observed by hydrophobicity, autoaggregation, coaggregation, and in vitro cell adhesion ability.
Moreover, the isolate also exhibited resistance against bad bacteria and simulated gastric juice at pH 3.0.
Based on the findings researchers suggested that a novel strain of lactic acid bacterium isolated from fermented cucumber protected the digestive tract against the injection of antibiotics, inhibited the production of bad bacteria such as gram-positive bacterial and utilized the effects of prebiotics such as inulin and raffinose.
Dr. Shukla R, the lead scientist said, " These results indicate both probiotic property and the glucan-sucrase-producing ability of P. pentosaceus CRAG3".
In vitro, in the evaluation of the probiotic potentials of three Bacillus strains 437F, 1630F, and 1020G obtained from the traditional pickle researchers found that
* All strains only showed high acid, and bile tolerance but also exhibited antagonistic activity against various pathogens.
* All strains exhibited antioxidant activity, auto- and co-aggregation ability and surface hydrophobicity and attachment capacity against the Caco-2 cells were similar to those of well-known probiotic strains.
* All strains are safe without causing harm to healthy colon cells.
Based on the findings, researchers said, "With respect to their characteristics and safety aspect, these Bacillus species may have the potential to consider as probiotics for animal and/or human applications".
Taken altogether, cucumber may be considered supplements for the protection of digestive functioning, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Probiotic Potential of Pediococcus pentosaceus CRAG3: A New Isolate from Fermented Cucumber by Shukla R1, Goyal A. (PubMed)
(2) Three novel Bacillus strains from a traditional lacto-fermented pickle as potential probiotics by Talebi S1, Makhdoumi A1, Bahreini M1, Matin MM1,2, Moradi HS. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li1. (PubMed)
#Phytochemical #Lycopene Protects the Bone Density Against the Onset of Osteoporopsis, Researchers Find
Kyle J. Norton
The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone which leads to bone resorption.
In patients with osteoporosis, this balance shifts in favor of osteoclasts compared to those of osteoblasts.
In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.
Furthermore, the imbalance of osteoclasts and osteoblasts also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.
Osteoclastogenesis is a procedure that included many stages, that interferes with the specific stage of the process, diseases associated with imbalanced osteoclasts, and osteoblast that may be preventable in the future.
Dr. Tobias Braun wrote, "Bone loss in RA patients is a frequent and clinically serious event. Considering bone remodeling in general, the balance between bone formation and bone resorption determines the net effect. In the past decade, significant gains in knowledge about the role of bone resorption during chronic erosive arthritis have been made. There is good evidence that inflammation itself triggers bone resorption by osteoclasts ".
And, "Pro-inflammatory cytokines are potent mediators of bone loss. These cytokines act both, directly and indirectly, to enhance osteoclastogenesis in the inflamed joint and systemic bone: first, many pro-inflammatory cytokines can alter the RANKL/OPG ratio in mesenchymal cells, such as osteoblasts and fibroblasts; second, some cytokines, such as M-CSF and RANKL, also directly affect osteoclast differentiation, survival, and activity".
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a potential phytochemical to protect bone density, researchers examined the osteoclastogenetic effect of lycopene.
According to the tested differentiation
* The ingestion of lycopene-containing products such as tomato showed a significant effect on decreased osteoclast differentiation. In other words, lycopene protected bone density by inhibiting bone reabsorption.
* Lycopene not only did not affect cell density/survival but also protected the bone by decreasing the calcium-phosphate resorption.
* Lycopene also acted as an MEK signaling inhibitor to promote bone formation.
* Additionally, lycopene also promoted an anabolic state of bone metabolism, through the regulation of the protein kinase C pathway associated with osteoclast formation and function potentially.
Based on the findings, lycopene protects bone mineral density by inhibiting the expression of osteoclastogenesis.
Researchers after taking into account co and confounders said, "This information might be relevant for the prevention and delay in the progression of osteolytic bone conditions".
Taken together, lycopene found in tomatoes may be considered supplements for the promotion of osteoclastogenesis, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene by Costa-Rodrigues J1, Fernandes MH2, Pinho O3, Monteiro PRR. (PubMed)
(2) Lycopene treatment against loss of bone mass, microarchitecture, and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model by Ardawi MM1, Badawoud MH2, Hassan SM2, Rouzi AA3, Ardawi JMS4, AlNosani NM4, Qari MH5, Mousa SA6. (PubMed)
(3) Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis by Tobias Braun1 and Jochen Zwerina. (PMC)
The osteoclast is a type of cell differentiated from another type of cell called a macrophage that breaks down the bone which leads to bone resorption.
In patients with osteoporosis, this balance shifts in favor of osteoclasts compared to those of osteoblasts.
In other words, in osteoporotic patients, bone resorption is far more exceedingly to bone formation.
Furthermore, the imbalance of osteoclasts and osteoblasts also is found in patients with Paget's disease, rheumatoid arthritis, osteopetrosis, periodontal disease, and bone cancer metastases.
Osteoclastogenesis is a procedure that included many stages, that interferes with the specific stage of the process, diseases associated with imbalanced osteoclasts, and osteoblast that may be preventable in the future.
Dr. Tobias Braun wrote, "Bone loss in RA patients is a frequent and clinically serious event. Considering bone remodeling in general, the balance between bone formation and bone resorption determines the net effect. In the past decade, significant gains in knowledge about the role of bone resorption during chronic erosive arthritis have been made. There is good evidence that inflammation itself triggers bone resorption by osteoclasts ".
And, "Pro-inflammatory cytokines are potent mediators of bone loss. These cytokines act both, directly and indirectly, to enhance osteoclastogenesis in the inflamed joint and systemic bone: first, many pro-inflammatory cytokines can alter the RANKL/OPG ratio in mesenchymal cells, such as osteoblasts and fibroblasts; second, some cytokines, such as M-CSF and RANKL, also directly affect osteoclast differentiation, survival, and activity".
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a potential phytochemical to protect bone density, researchers examined the osteoclastogenetic effect of lycopene.
According to the tested differentiation
* The ingestion of lycopene-containing products such as tomato showed a significant effect on decreased osteoclast differentiation. In other words, lycopene protected bone density by inhibiting bone reabsorption.
* Lycopene not only did not affect cell density/survival but also protected the bone by decreasing the calcium-phosphate resorption.
* Lycopene also acted as an MEK signaling inhibitor to promote bone formation.
* Additionally, lycopene also promoted an anabolic state of bone metabolism, through the regulation of the protein kinase C pathway associated with osteoclast formation and function potentially.
Based on the findings, lycopene protects bone mineral density by inhibiting the expression of osteoclastogenesis.
Researchers after taking into account co and confounders said, "This information might be relevant for the prevention and delay in the progression of osteolytic bone conditions".
Taken together, lycopene found in tomatoes may be considered supplements for the promotion of osteoclastogenesis, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene by Costa-Rodrigues J1, Fernandes MH2, Pinho O3, Monteiro PRR. (PubMed)
(2) Lycopene treatment against loss of bone mass, microarchitecture, and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model by Ardawi MM1, Badawoud MH2, Hassan SM2, Rouzi AA3, Ardawi JMS4, AlNosani NM4, Qari MH5, Mousa SA6. (PubMed)
(3) Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis by Tobias Braun1 and Jochen Zwerina. (PMC)
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