#Furanodiene Isolated from #Turmeric Processes Anti-Metastatic Activity, Scientists Suggest

Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including unintended weight loss, loss of appetite, fatigue, and tiredness, and gastrointestinal problems.

Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.


Metastasis is the process to induce the development of secondary malignant growths at a distance from primary cancer.

Metastatic cancer also shares the characteristics of primary cancer. Breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer.

According to statistics, in 2018, approximately over1,700,000 cases of cancer were diagnosed worldwide. The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Believe it or not, some metastatic cancer may have an unknown primary origin or CUP, secondary cancer without a primary cancer site.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the prevention of metastasis in cancer, researchers examined the effects of Furanodiene, a bioactive compound isolated from Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin) on tumor metastatic activities.

According to the tested differentiation, low concentrations (5-25μM) of furanodiene inhibited adhesion, migration, and invasion of breast cancer cells, without inducing cytotoxicity, apoptosis and cell cycle arrest.

Furthermore, furanodiene also regulated the parameters such as the integrin αV expression, β-catenin expression, associated with the cell survival, migration, proliferation, differentiation, angiogenesis, and remodeling of the extracellular matrix in the modulation of the tumor metastasis process.

In MDA-MB-231 cells, furanodiene modulated the matrix metalloproteinase 9 (MMP-9) involved in tumor metastasis and cancer markers.

Based on the results Dr. Zhong Z, the lead scientist said, "furanodiene might be the primary contributor to the anti-cancer effects of volatile oil extracts, and it might be a good therapeutic target for highly metastatic breast cancer".

Taken together, turmeric processed with a high amount of bioactive compound furanodiene may be considered a supplement for the prevention of tumor metastasis, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro by Zhong Z1, Tan W1, Chen X2, Wang Y. (PubMed)