Kyle J. Norton
Bowel problems may be a condition associated with some underlying diseases or syndrome including bowel incontinence, IBS, Colitis, Crohn's, constipation, or other bowel conditions.
Bowel problems can be cured if the causes of the problem are found.
The most common syndrome that does not associate with the underlying disease is constipation, a condition that affects bowel movements.
According to the statistics in the US, constipation affects approximately 2% of the population and the condition is more common in women than men.
Patients with constipation may experience symptoms of abdominal pain, bloating, and the feeling of not completely passing the bowel movement.
Chronic constipation is one of the common causes of hemorrhoids, anal fissures or fecal impaction.
Conventionally, constipation in most cases is treated by the use of a laxative. However long-term use of laxatives may induce diarrhea, intestinal obstruction, and particularly unbalanced levels of salts and minerals in your body.
Therefore, if you currently use one of the over-counter laxatives for the treatment of constipation, please make you know all the side effects for preventive measures.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
In finding a natural compound with bowel health promotion activity, researchers compared the effects of probiotic-enriched artichokes on the treatment of the symptom profile and short-chain fatty acid (SCFA) production in constipated subjects with ordinary artichokes.
20 chronically constipated participants including 3 males and 17 female have selected to a double-blind method and a computer-generated randomization list.
Each patient consumed 180 g per day of ordinary artichokes or artichokes enriched with Lactobacillus paracasei IMPC 2.1 for 15 days.
According to the returned questionnaires, 80% of patients preferred probiotic-enriched artichokes compared to ordinary ones.
The satisfactory relief of symptoms was significantly higher in the probiotic-enriched artichoke compared to ordinary ones.
According to the Bristol stool scale the measurement of fecal retention was lower in the probiotic-enriched artichokes compared to higher in the artichoke group seconded to the control.
GSRS (Gastrointestinal Symptom Rating Scale) of constipation was significantly lower in the probiotic group compared with the baseline.
Furthermore, the short-chain fatty acid (SCFA) production and propionic acid were significantly higher in the probiotic group compared with the baseline.
In order to reveal more information on artichokes in the promotion of bowel health, researchers investigated the chemical compounds inulin and oligofructose, a class of fructans found in the Jerusalem artichoke.
Injection of inulin and oligofructose was found to stimulate the immune system of the body, decrease the pathogenic bacteria in the intestine, and relieve constipation.
Furthermore, inulin and oligofructose also displayed significant effects in the promotion of bowel health by protecting the colon against colon cancer.
Taken together, artichoke, particularly Jerusalem artichoke alone or combined with probiotics may be considered functional remedies for the improvement of bowel health, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Randomised clinical trial: efficacy of Lactobacillus paracasei-enriched artichokes in the treatment of patients with functional constipation--a double-blind, controlled, crossover study by Riezzo G1, Orlando A, D'Attoma B, Guerra V, Valerio F, Lavermicocca P, De Candia S, Russo F. (PubMed)
(2) Applications of inulin and oligofructose in health and nutrition by Kaur N1, Gupta AK. (PubMed)
Monday, 14 August 2023
#Bromelain Shows A Clinically Relevant Improvement in the WOMAC Disability Subscale in Osteoarthritis (OA) Similar to Those of Diclofenac with No Side Effects
By Kyle J. Norton
Osteoarthritis (OA), a form of arthritis, is a condition associated with aging-induced wear and tear on a joint or joint.
The condition is very common in older adults, affecting over 25 million people in the US with no sign of stopping.
According to the University of Porto Medical School, the differences in prevalence and incidence estimates of osteoarthritis (OA), according to the case definition, are in the knee, hip, and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty in moving the joint or joints(7). The pain usually gets worse in a change of weather, at night.
In advanced diseases, pain can occur even at rest(8).
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).
Some researchers suggested that OA is not simply a disease related to aging or mechanical stress of joints but rather a “metabolic disorder(70)(71)” interrelated to lipid, metabolic, and humoral mediators(70).
Indeed, OA has been linked not only to obesity(46)(47) but also to other cardiovascular risk factors(72)(73), namely, diabetes(74), dyslipidemia, hypertension, and insulin resistance(75).
More precisely, the majority of patients with OA also suffer from one or more of the below conditions
* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).
* Cardiovascular disease
According to Erasmus University Medical Centre, there is an association of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).
*Peripheral vascular disease
According to Himchan Hospital, patients with osteoarthritis are associated with a risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).
* Congestive heart failure
Hypertension, diabetes, and older age have been shown to increase the risk of Congestive heart failure modestly(81).
* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83).
6. Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).
* Respiratory disease
People with respiratory disease are also at a higher risk to develop osteoarthritis (OA), including chronic cough and bilateral infiltrates on chest roentgenogram(86).
* High serum of cholesterol
There is an association between high serum cholesterol levels and both knee and generalized OA, according to the study of 113 females and 133 males with average ages 46 14.2 and 51.54 16.0 years by King Khalid University Hospital(87).
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In finding a natural compound from healthy food for the treatment of inflammatory diseases, researchers examined the effects of bromelain on patients with osteoarthritis of the knee.
The randomized, double-blind placebo-controlled trial included 47 patients with a confirmed diagnosis of moderate to severe knee OA randomized to 12 weeks of bromelain 800 mg/day or placebo, with a 4-week follow-up.
According to the results from 31 patients who completed the trial, including 14 in the bromelain group and 17 in the placebo group, both treatment groups showed clinically relevant improvement in the WOMAC disability subscale only with a mild adverse outcome.
In order to reveal and confirm the effects of bromelain on OA, a joint randomized, single-blind, active-controlled pilot study. led by Mahidol University was conducted in patients with OA for 16 weeks.
40 knee OA patients enrolled in the study were randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).
According to the tested assays,
* At week 4, the improvement of total WOMAC and pain subscales from baseline was observed in both groups, however, two patients in the diclofenac treatment group showed adverse effects that lead to discontinuation of diclofenac.
* At week 16, the bromelain treatment group showed a significant improvement in all aspects, including total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4), compared to baseline values.
* Also compared to the based line, the bromelain-treated group also showed a decrease of plasma MDA and LPS-stimulated PGE2 production,
* Bromelain exerted a similar effect to those of diclofenac after 4 weeks.
Taken altogether, bromelain used alone may be considered supplements for the prevention and treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study by Brien S1, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. (PubMed)
(2) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: Diseases associated with Osteoarthritis by Kyle J. Norton
Osteoarthritis (OA), a form of arthritis, is a condition associated with aging-induced wear and tear on a joint or joint.
The condition is very common in older adults, affecting over 25 million people in the US with no sign of stopping.
According to the University of Porto Medical School, the differences in prevalence and incidence estimates of osteoarthritis (OA), according to the case definition, are in the knee, hip, and hand joints(3).
The characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty in moving the joint or joints(7). The pain usually gets worse in a change of weather, at night.
In advanced diseases, pain can occur even at rest(8).
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).
Some researchers suggested that OA is not simply a disease related to aging or mechanical stress of joints but rather a “metabolic disorder(70)(71)” interrelated to lipid, metabolic, and humoral mediators(70).
Indeed, OA has been linked not only to obesity(46)(47) but also to other cardiovascular risk factors(72)(73), namely, diabetes(74), dyslipidemia, hypertension, and insulin resistance(75).
More precisely, the majority of patients with OA also suffer from one or more of the below conditions
* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).
* Cardiovascular disease
According to Erasmus University Medical Centre, there is an association of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).
*Peripheral vascular disease
According to Himchan Hospital, patients with osteoarthritis are associated with a risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).
* Congestive heart failure
Hypertension, diabetes, and older age have been shown to increase the risk of Congestive heart failure modestly(81).
* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83).
6. Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).
* Respiratory disease
People with respiratory disease are also at a higher risk to develop osteoarthritis (OA), including chronic cough and bilateral infiltrates on chest roentgenogram(86).
* High serum of cholesterol
There is an association between high serum cholesterol levels and both knee and generalized OA, according to the study of 113 females and 133 males with average ages 46 14.2 and 51.54 16.0 years by King Khalid University Hospital(87).
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In finding a natural compound from healthy food for the treatment of inflammatory diseases, researchers examined the effects of bromelain on patients with osteoarthritis of the knee.
The randomized, double-blind placebo-controlled trial included 47 patients with a confirmed diagnosis of moderate to severe knee OA randomized to 12 weeks of bromelain 800 mg/day or placebo, with a 4-week follow-up.
According to the results from 31 patients who completed the trial, including 14 in the bromelain group and 17 in the placebo group, both treatment groups showed clinically relevant improvement in the WOMAC disability subscale only with a mild adverse outcome.
In order to reveal and confirm the effects of bromelain on OA, a joint randomized, single-blind, active-controlled pilot study. led by Mahidol University was conducted in patients with OA for 16 weeks.
40 knee OA patients enrolled in the study were randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day).
According to the tested assays,
* At week 4, the improvement of total WOMAC and pain subscales from baseline was observed in both groups, however, two patients in the diclofenac treatment group showed adverse effects that lead to discontinuation of diclofenac.
* At week 16, the bromelain treatment group showed a significant improvement in all aspects, including total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4), compared to baseline values.
* Also compared to the based line, the bromelain-treated group also showed a decrease of plasma MDA and LPS-stimulated PGE2 production,
* Bromelain exerted a similar effect to those of diclofenac after 4 weeks.
Taken altogether, bromelain used alone may be considered supplements for the prevention and treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study by Brien S1, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. (PubMed)
(2) Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis by Kasemsuk T1, Saengpetch N2, Sibmooh N1, Unchern S. (PubMed)
(3) Most Common Disease of Elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: Diseases associated with Osteoarthritis by Kyle J. Norton
Short-Chain Fructooligosaccharides (FOS) Found in #Herbal #Artichoke Health Benefits in the Inhibition of #Diabetes and #CardiovascularDisease
Kyle J. Norton
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Fructooligosaccharides (FOS), are oligosaccharides, a molecule made up of a small group of these sugar,
Due to its nature as a natural source of sugar and low in calories, FOS may be used as an alternative sweetener as intake of FOS does not cause a spike in blood sugar.
FOS are considered prebiotics. Intake of FOS can increase the levels of good bacteria in the intestine, leading to a healthy ratio of gut microbiota.
Digestively, FOS contains high levels of soluble fiber which has been found to improve bowel function. Consumption of FOS also increased fecal bolus and the frequency of depositions, while a dose of 4-15 g/day given to healthy subjects has been found to reduce constipation.
According to the study, FOS also showed anti-toxicity, carcinogenicity, and genotoxic effects.
FOS improved mineral absorption by decreasing levels of pH in the colon, thus facilitating the absorption of mineral ions from the intestine, mainly calcium and magnesium
Furthermore, FOS has also been found in studies to decrease levels of serum cholesterol, and triacylglycerols, the lead causes of cardiovascular diseases.
By modulating the levels of phospholipids, FOS lowers the risk of coronary heart disease, inflammation, or cancer, particularly colon cancer.
In foods, FOS are increasingly included in food products and infant formulas for their prebiotic effect in stimulating the growth of nonpathogenic intestinal microflora.
In the examined the effects of chronic ingestion of short-chain fructooligosaccharides (FOS), an indigestible carbohydrate, on hepatic glucose production, insulin-mediated glucose metabolism, erythrocyte insulin binding, and blood lipids in 12 healthy volunteers selected received either 20 g FOS/d or sucrose for 4 wk in a double-blind crossover design, researchers found that the mean (+/- SEM) basal hepatic glucose production was lower after FOS than after sucrose consumption, through the effects on insulin-stimulated glucose metabolism in healthy subjects.
Taken together, artichoke processes many health benefits that may be used as a functional remedy for disease prevention in healthy subjects, pending to the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Dietary fructooligosaccharides and potential benefits on health by Sabater-Molina M1, Larqué E, Torrella F, Zamora S. (PubMed)
(2) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism by Luo J1, Rizkalla SW, Alamowitch C, Boussairi A, Blayo A, Barry JL, Laffitte A, Guyon F, Bornet FR, Slama G. (PubMed)
(3) Fructooligosaccharides: a review by Fishbein L1, Kaplan M, Gough M. (PubMed)
(4) Fructooligosaccharides: Applications and Health benefits- a review by SHUBHANGI S. KHANVILKAR, Shalini S. Arya*
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Fructooligosaccharides (FOS), are oligosaccharides, a molecule made up of a small group of these sugar,
Due to its nature as a natural source of sugar and low in calories, FOS may be used as an alternative sweetener as intake of FOS does not cause a spike in blood sugar.
FOS are considered prebiotics. Intake of FOS can increase the levels of good bacteria in the intestine, leading to a healthy ratio of gut microbiota.
Digestively, FOS contains high levels of soluble fiber which has been found to improve bowel function. Consumption of FOS also increased fecal bolus and the frequency of depositions, while a dose of 4-15 g/day given to healthy subjects has been found to reduce constipation.
According to the study, FOS also showed anti-toxicity, carcinogenicity, and genotoxic effects.
FOS improved mineral absorption by decreasing levels of pH in the colon, thus facilitating the absorption of mineral ions from the intestine, mainly calcium and magnesium
Furthermore, FOS has also been found in studies to decrease levels of serum cholesterol, and triacylglycerols, the lead causes of cardiovascular diseases.
By modulating the levels of phospholipids, FOS lowers the risk of coronary heart disease, inflammation, or cancer, particularly colon cancer.
In foods, FOS are increasingly included in food products and infant formulas for their prebiotic effect in stimulating the growth of nonpathogenic intestinal microflora.
In the examined the effects of chronic ingestion of short-chain fructooligosaccharides (FOS), an indigestible carbohydrate, on hepatic glucose production, insulin-mediated glucose metabolism, erythrocyte insulin binding, and blood lipids in 12 healthy volunteers selected received either 20 g FOS/d or sucrose for 4 wk in a double-blind crossover design, researchers found that the mean (+/- SEM) basal hepatic glucose production was lower after FOS than after sucrose consumption, through the effects on insulin-stimulated glucose metabolism in healthy subjects.
Taken together, artichoke processes many health benefits that may be used as a functional remedy for disease prevention in healthy subjects, pending to the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Dietary fructooligosaccharides and potential benefits on health by Sabater-Molina M1, Larqué E, Torrella F, Zamora S. (PubMed)
(2) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism by Luo J1, Rizkalla SW, Alamowitch C, Boussairi A, Blayo A, Barry JL, Laffitte A, Guyon F, Bornet FR, Slama G. (PubMed)
(3) Fructooligosaccharides: a review by Fishbein L1, Kaplan M, Gough M. (PubMed)
(4) Fructooligosaccharides: Applications and Health benefits- a review by SHUBHANGI S. KHANVILKAR, Shalini S. Arya*
#Anthocyanin-rich #Bilberry Inhibits the Active-#UlcerativeColitis, through Its Antioxidative and Anti-Inflammatory Activity
Kyle J. Norton
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) caused by the inflammation associated with the colon and rectum.
Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus, persistent abdominal pain, rectal pain, and bleeding, particularly the inability to defecate despite the urgency.
Some patients with UC may also have symptoms of weight loss, and fatigue fever.
According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.
Depending on the location, the most common types of UC can be classified into
* Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, and fever.
* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.
* Proctosigmoiditis is an Inflammation involved in the rectum and sigmoid colon (lower end of the colon).
The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.
The most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.
Some researchers suggested that UC may be correlated with the increase of age as the disease affected 10–30% of the population older than 60 years.
Dr. Wei-Chen, the lead scientist wrote, " Elderly patients with UC will be seen more frequently with the aging of the population and increasing incidence of UC. The management of UC in the elderly population is more complex due to comorbidities and polypharmacy".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
In finding a natural compound or whole food for the treatment of ulcerative colitis (UC), as a significant fraction of patients with ulcerative colitis (UC) is not sufficiently controlled with conventional therapy or suffer from therapy-related side effects, researchers examined the anthocyanin-rich bilberry extract (ARBE) on the colon specimens obtained during an open pilot study using ARBE for the treatment of mild-to-moderate UC.
Pretreatment of ARBE inhibited the expression of IFN-γ-receptor 2 which plays a critical role in the regulation of mediated immune responses and organ-specific autoimmunity in human THP-1 monocytic cells.
After 6 weeks of treatment, ARBE treatment revealed reduced production of the pro-inflammatory cytokines including IFN-γ and TNF-α.
Furthermore, ARBE treatment featured enhanced levels of Th17-cell-specific cytokine IL-22 and immunoregulatory cytokine IL-10 by restoring the balance between Th17 and Treg cells and preventing the risk of chronic inflammation and pathogenesis of many autoimmune diseases.
Dr. Roth S, the lead scientist after taking other factors into account wrote, "a molecular mechanism underlying the anti-inflammatory effects of ARBE treatment in UC patients by modulating T-cell cytokine signaling and inhibiting IFN-γ signal transduction".
In order to reveal more information about the bilberry (Vaccinium myrtillus) property on UC, researchers analyzed the antioxidative and anti-inflammatory effects with an aim to explore the therapeutic potential of bilberries in the active UC.
The open pilot trial with a total follow-up of 9 weeks the effect of a daily standardized anthocyanin-rich bilberry preparation included 13 patients with mild to moderate UC.
At the end of the 6-week treatment interval, 63.4% of patients achieved remission, the primary endpoint, while 90.9% of patients showed a response.
In all patients, a decrease in total Mayo score was detected (mean: 6.5 and 3.6 at screening and week 7, respectively; p<0.001).
Fecal calprotectin levels significantly decreased during the treatment phase (baseline: mean 778 μg/g, range 192-1790 μg/g; end of treatment: mean 305 μg/g, range <30-1586 μg/g; p=0.049), including 4 patients achieving undetectable levels at end of treatment.
No serious adverse events were observed.
The finding strongly supports the regular use of standardized anthocyanin-rich bilberry preparation in UC in humans.
Dr. Biedermann L, said at the end of the experience, "These results clearly indicate a therapeutic potential of bilberries in UC. Further studies on mechanisms and randomized clinical trials are warranted".
Taken together, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of UC, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis by Roth S1, Spalinger MR1, Gottier C1, Biedermann L1, Zeitz J1, Lang S1, Weber A2, Rogler G1,3, Scharl M. (PubMed)
(2) Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study by Biedermann L1, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, Vavricka SR, Fried M, Weber A, Humpf HU, Peschke S, Jetter A, Krammer G, Rogler G. (PubMed)
(3) Ulcerative Colitis in Elderly People: An Emerging Issue by Wei-ChenLin, Ming-JenChen, Cheng-HsinChua, Tsang-EnWang, Horng-YuanWang, Chen-WangChang. (Science Direct)
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) caused by the inflammation associated with the colon and rectum.
Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus, persistent abdominal pain, rectal pain, and bleeding, particularly the inability to defecate despite the urgency.
Some patients with UC may also have symptoms of weight loss, and fatigue fever.
According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.
Depending on the location, the most common types of UC can be classified into
* Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, and fever.
* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.
* Proctosigmoiditis is an Inflammation involved in the rectum and sigmoid colon (lower end of the colon).
The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.
The most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.
Some researchers suggested that UC may be correlated with the increase of age as the disease affected 10–30% of the population older than 60 years.
Dr. Wei-Chen, the lead scientist wrote, " Elderly patients with UC will be seen more frequently with the aging of the population and increasing incidence of UC. The management of UC in the elderly population is more complex due to comorbidities and polypharmacy".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
In finding a natural compound or whole food for the treatment of ulcerative colitis (UC), as a significant fraction of patients with ulcerative colitis (UC) is not sufficiently controlled with conventional therapy or suffer from therapy-related side effects, researchers examined the anthocyanin-rich bilberry extract (ARBE) on the colon specimens obtained during an open pilot study using ARBE for the treatment of mild-to-moderate UC.
Pretreatment of ARBE inhibited the expression of IFN-γ-receptor 2 which plays a critical role in the regulation of mediated immune responses and organ-specific autoimmunity in human THP-1 monocytic cells.
After 6 weeks of treatment, ARBE treatment revealed reduced production of the pro-inflammatory cytokines including IFN-γ and TNF-α.
Furthermore, ARBE treatment featured enhanced levels of Th17-cell-specific cytokine IL-22 and immunoregulatory cytokine IL-10 by restoring the balance between Th17 and Treg cells and preventing the risk of chronic inflammation and pathogenesis of many autoimmune diseases.
Dr. Roth S, the lead scientist after taking other factors into account wrote, "a molecular mechanism underlying the anti-inflammatory effects of ARBE treatment in UC patients by modulating T-cell cytokine signaling and inhibiting IFN-γ signal transduction".
In order to reveal more information about the bilberry (Vaccinium myrtillus) property on UC, researchers analyzed the antioxidative and anti-inflammatory effects with an aim to explore the therapeutic potential of bilberries in the active UC.
The open pilot trial with a total follow-up of 9 weeks the effect of a daily standardized anthocyanin-rich bilberry preparation included 13 patients with mild to moderate UC.
At the end of the 6-week treatment interval, 63.4% of patients achieved remission, the primary endpoint, while 90.9% of patients showed a response.
In all patients, a decrease in total Mayo score was detected (mean: 6.5 and 3.6 at screening and week 7, respectively; p<0.001).
Fecal calprotectin levels significantly decreased during the treatment phase (baseline: mean 778 μg/g, range 192-1790 μg/g; end of treatment: mean 305 μg/g, range <30-1586 μg/g; p=0.049), including 4 patients achieving undetectable levels at end of treatment.
No serious adverse events were observed.
The finding strongly supports the regular use of standardized anthocyanin-rich bilberry preparation in UC in humans.
Dr. Biedermann L, said at the end of the experience, "These results clearly indicate a therapeutic potential of bilberries in UC. Further studies on mechanisms and randomized clinical trials are warranted".
Taken together, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of UC, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis by Roth S1, Spalinger MR1, Gottier C1, Biedermann L1, Zeitz J1, Lang S1, Weber A2, Rogler G1,3, Scharl M. (PubMed)
(2) Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study by Biedermann L1, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, Vavricka SR, Fried M, Weber A, Humpf HU, Peschke S, Jetter A, Krammer G, Rogler G. (PubMed)
(3) Ulcerative Colitis in Elderly People: An Emerging Issue by Wei-ChenLin, Ming-JenChen, Cheng-HsinChua, Tsang-EnWang, Horng-YuanWang, Chen-WangChang. (Science Direct)
#Herbal #Arnica Improves All Aspects of Symptoms of Osteoarthritis, Scientists Reveal
Kyle J. Norton
Arnica may have a substantial and positive effect on reduced risk and treatment of osteoarthritis, some scientists suggested.
Osteoarthritis (OA), a form of arthritis, is a chronic condition characterized by wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
The University of Porto Medical School suggested that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).
The most common symptoms of osteoarthritis are aching pain, stiffness, or difficulty moving the joint or joints.
The pain usually gets worse in the change of weather, at night and in the advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.
An unhealthy diet that causes nutrient deficiency and overload, damage of cartilage, a joint injury that did not heal properly, overuse, and autoimmune rheumatoid arthritis also have potential effects on the increased prevalence of osteoarthritis.
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is the process of repairing damage to the skin, tissues, organs, etc.
In a randomized, double-blind study of 204 patients to investigate the effect of ibuprofen (5%) and Arnica (50 g tincture/100 g, DER 1:20), as gel preparations in patients with radiologically confirmed and symptomatically active osteoarthritis of interphalangeal joints of hands, researchers found that after 21 days of treatment, group treated with Arnica exerted a significant effect in relieve and function of the joints of hands similar to group treated with the conventional medicine.
4.8% in the Arnica group reported some tolerate adverse effects compared to 6.1% in the group treated with ibuprofen.
After taking into account other co and con factors, Dr. the lead researcher said, "Our results confirm that this preparation of Arnica is not inferior to ibuprofen when treating osteoarthritis of the hands".
In other to confirm the effect of Arnica as a form of functional food for the treatment of osteoarthritis, scientists at the Valens Clinic for Rheumatism conducted a study of topical application of Arnica montana fresh plant gel twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee.
According to the study, treatment after 3 and 6 weeks demonstrated a strong improvement in the median total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), used by health professionals with a proprietary set of standardized questionnaires to evaluate the condition of patients with osteoarthritis, including knee and hip, including pain, stiffness, and physical functioning of the joints.
Furthermore, in regard to the symptoms expression of osteoarthritis, the application of the herbal preparation exerted a significant reduction of pain, and stiffness, observed by the pain and stiffness score.
A score of the mean of function subscales also showed significant reductions at these time points.
The physical function subscale found in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is considered more consistent with stronger test-retest reliability compared to the pain score with some inconsistencies across the studies.
However, local tolerate adverse effects were reported in 7.6 % of patients who attended the study with one patient with an allergic reaction.
Interestingly, at the end of the study, 87% rated the tolerability of the gel as "good" or "fairly good," and 76% would use it again.
These results indicated that topical application of Arnica montana gel for 6 weeks alleviated symptoms of osteoarthritis in all aspects and may be considered as a well-tolerated, and effective treatment of mild to moderate OA of the knee.
Taken together, as a topical herbal medicine, Arnica may be considered a functional food for attenuated symptoms and treatment of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomized, double-blind study by Widrig R1, Suter A, Saller R, Melzer J.(PubMed)
(2) Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial by Knuesel O1, Weber M, Suter A.(PubMed)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)
Arnica may have a substantial and positive effect on reduced risk and treatment of osteoarthritis, some scientists suggested.
Osteoarthritis (OA), a form of arthritis, is a chronic condition characterized by wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
The University of Porto Medical School suggested that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).
The most common symptoms of osteoarthritis are aching pain, stiffness, or difficulty moving the joint or joints.
The pain usually gets worse in the change of weather, at night and in the advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.
An unhealthy diet that causes nutrient deficiency and overload, damage of cartilage, a joint injury that did not heal properly, overuse, and autoimmune rheumatoid arthritis also have potential effects on the increased prevalence of osteoarthritis.
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is the process of repairing damage to the skin, tissues, organs, etc.
In a randomized, double-blind study of 204 patients to investigate the effect of ibuprofen (5%) and Arnica (50 g tincture/100 g, DER 1:20), as gel preparations in patients with radiologically confirmed and symptomatically active osteoarthritis of interphalangeal joints of hands, researchers found that after 21 days of treatment, group treated with Arnica exerted a significant effect in relieve and function of the joints of hands similar to group treated with the conventional medicine.
4.8% in the Arnica group reported some tolerate adverse effects compared to 6.1% in the group treated with ibuprofen.
After taking into account other co and con factors, Dr. the lead researcher said, "Our results confirm that this preparation of Arnica is not inferior to ibuprofen when treating osteoarthritis of the hands".
In other to confirm the effect of Arnica as a form of functional food for the treatment of osteoarthritis, scientists at the Valens Clinic for Rheumatism conducted a study of topical application of Arnica montana fresh plant gel twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee.
According to the study, treatment after 3 and 6 weeks demonstrated a strong improvement in the median total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), used by health professionals with a proprietary set of standardized questionnaires to evaluate the condition of patients with osteoarthritis, including knee and hip, including pain, stiffness, and physical functioning of the joints.
Furthermore, in regard to the symptoms expression of osteoarthritis, the application of the herbal preparation exerted a significant reduction of pain, and stiffness, observed by the pain and stiffness score.
A score of the mean of function subscales also showed significant reductions at these time points.
The physical function subscale found in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is considered more consistent with stronger test-retest reliability compared to the pain score with some inconsistencies across the studies.
However, local tolerate adverse effects were reported in 7.6 % of patients who attended the study with one patient with an allergic reaction.
Interestingly, at the end of the study, 87% rated the tolerability of the gel as "good" or "fairly good," and 76% would use it again.
These results indicated that topical application of Arnica montana gel for 6 weeks alleviated symptoms of osteoarthritis in all aspects and may be considered as a well-tolerated, and effective treatment of mild to moderate OA of the knee.
Taken together, as a topical herbal medicine, Arnica may be considered a functional food for attenuated symptoms and treatment of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomized, double-blind study by Widrig R1, Suter A, Saller R, Melzer J.(PubMed)
(2) Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial by Knuesel O1, Weber M, Suter A.(PubMed)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)
#Phytochemical #Quercetin Isolated from #Onion Inhibits the Expression of Enzymes and Proteins Associated with Cancer Development, Researchers Suggest
Kyle J. Norton
Oral cancer is a medical condition of malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).
The most common types of oral cancer are
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting for over 90% of all cases and arises from the squamous cell layer in the lining of the oral cavity and oropharynx.
* Verrucous carcinoma
The low-grade and rarely spread verrucous carcinoma is accounted for only approximately 5% of all cases. The cancer can spread deeply into the surrounding tissue.
* Minor salivary gland cancers
The cancer originated from the salivary gland and accounted for less than 1% of all cases.
According to the statistics, approximately, 53,000 Americans will be diagnosed with oral or oropharyngeal cancer in 2019.
The disease also causes the death of over 9,750 patients, roughly 1 person per hour, 24 hours per day.
The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The 5-year survival rate of the localized stage of oral cancer is 84%. However, If cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the overall 5-year survival rate is 65%.
The survival rate is even lower (39%) If cancer has spread to a distant part of the body,
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
In the urgency to find a potential compound for the treatment of oral cancer, researchers investigated the potential effects of quercetin, a principal flavonoid compound in onions' anti-oral cancer activities.
On SAS human oral cancer cells, quercetin significantly reduced wound closure of SAS cells in culture plates after 12- and 24-h treatments.
Quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 promotes cancer cell growth and proliferation and (MMP)-9 is involved in cancer cells' angiogenesis and metastasis.
Additionally, quercetin also inhibited the proteins associated with the promotion of forming new blood vessels in SAS human oral cancer cells.
Furthermore, quercetin also blocked the expression of enzymes associated with the pathogenesis of many solid tumors through its inflammatory activation.
Moreover, proteins involved in cellular interactions with the extracellular matrix that cause tumor initiation, progression, and metastasis were also inhibited by the injection of quercetin.
More importantly, quercetin also exhibited the gene expression of tumor suppression such as P53 and apoptosis.
In other words, quercetin protects the oral cells by blocking the proteins involved in the signaling expression of tumor initiation, progression, and metastasis such as Ras homolog gene family, member A (RhoA), and protein kinase C (PKC).
Taken altogether, onion may be considered a remedy for the prevention and treatment of oral cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)
(2) Mouth ( Oral Cancer) Cancer by Kyle J. Norton
Oral cancer is a medical condition of malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).
The most common types of oral cancer are
* Squamous cell carcinoma
Squamous cell carcinoma is one of the most common types of oral cancer accounting for over 90% of all cases and arises from the squamous cell layer in the lining of the oral cavity and oropharynx.
* Verrucous carcinoma
The low-grade and rarely spread verrucous carcinoma is accounted for only approximately 5% of all cases. The cancer can spread deeply into the surrounding tissue.
* Minor salivary gland cancers
The cancer originated from the salivary gland and accounted for less than 1% of all cases.
According to the statistics, approximately, 53,000 Americans will be diagnosed with oral or oropharyngeal cancer in 2019.
The disease also causes the death of over 9,750 patients, roughly 1 person per hour, 24 hours per day.
The grades of oral cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The 5-year survival rate of the localized stage of oral cancer is 84%. However, If cancer has spread to surrounding tissues or organs and/or the regional lymph nodes, the overall 5-year survival rate is 65%.
The survival rate is even lower (39%) If cancer has spread to a distant part of the body,
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
In the urgency to find a potential compound for the treatment of oral cancer, researchers investigated the potential effects of quercetin, a principal flavonoid compound in onions' anti-oral cancer activities.
On SAS human oral cancer cells, quercetin significantly reduced wound closure of SAS cells in culture plates after 12- and 24-h treatments.
Quercetin inhibited the expression and activity of matrix metalloproteinase (MMP)-2 promotes cancer cell growth and proliferation and (MMP)-9 is involved in cancer cells' angiogenesis and metastasis.
Additionally, quercetin also inhibited the proteins associated with the promotion of forming new blood vessels in SAS human oral cancer cells.
Furthermore, quercetin also blocked the expression of enzymes associated with the pathogenesis of many solid tumors through its inflammatory activation.
Moreover, proteins involved in cellular interactions with the extracellular matrix that cause tumor initiation, progression, and metastasis were also inhibited by the injection of quercetin.
More importantly, quercetin also exhibited the gene expression of tumor suppression such as P53 and apoptosis.
In other words, quercetin protects the oral cells by blocking the proteins involved in the signaling expression of tumor initiation, progression, and metastasis such as Ras homolog gene family, member A (RhoA), and protein kinase C (PKC).
Taken altogether, onion may be considered a remedy for the prevention and treatment of oral cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways by Lai WW1, Hsu SC, Chueh FS, Chen YY, Yang JS, Lin JP, Lien JC, Tsai CH, Chung JG. (PubMed)
(2) Mouth ( Oral Cancer) Cancer by Kyle J. Norton
#BlackBeans Improve Insulin Resistance and Enhance Anti Inflammatory Metabolic Syndrome Activity, Researchers Say
Kyle J. Norton
Inflammation is a natural response of the immune system to protect our body against injury and damage-induced infection.
Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was the first domesticated growth in South America.
Black or common beans with abundant phytochemicals may be considered functional foods in attenuated pro-inflammatory expression induced by immunity during injured, a respectable institute postulated.
In a randomized, controlled, crossover trial of 12 adults with metabolic syndrome (MetS) who consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) study, researchers found that blood sample collection before (fasting) and five hours after the meal, black bean intake group showed a significant expression of plasma antioxidant capacity and inflammatory cytokines in response to meals differences over time.
This result showed strong support for black bean intake reduced levels of oxidative stress-induced inflammation and enhanced production of antioxidants.
Dr. Reverri EJ the lead researcher said, " Inclusion of black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints".
In other words, adding a portion of black bean may improve insulin resistance and induce antioxidant activity to modify the risk and treatment of inflammatory metabolic syndrome.
In colon inflammation triggered by high-fat diet (HD)-induced obesity in mice, mice fed with black bean showed a remarkable effect in a reduced pro-inflammatory expression such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, by attenuating changes associated with HD-induced colon inflammation.
Additionally, black bean-fed mice also demonstrated a significant improvement of antioxidants through modulated colon mRNA expression and reduced macrophage infiltration into adipose tissue, causing inflammation.
Furthermore, Dr. the lead author expressed, " BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-κB to decrease the production of proinflammatory cytokines".
Another study in support of the efficacy of black beans in ameliorated inflammation suggested that bean diets reduced not only mRNA expression of exhibited production of colonic inflammatory cytokines (IL-6, IL-9, IFN-γ, and IL-17A) and increased anti-inflammatory IL-10 (P< 0·05), but also systemically reduced circulating cytokines (IL-1β, TNFα, IFNγ, and IL-17A, P< 0·05) and dextran sodium sulfate-induced oxidative stress and colitis in animal model.
The findings suggested that black beans may be used as a functional food for the prevention of inflammation after body injury or damage by reduced levels of pro-inflammatory and increased levels of anti-inflammatory cytokines.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,7.(PubMed)
(2) Black Adzuki Bean (Vigna angularis) Attenuates High-Fat Diet-Induced Colon Inflammation in Mice by Yook JS1, Kim KA2, Kim M1, Cha YS1.(PubMed)
(3) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA1. (PubMed)
Inflammation is a natural response of the immune system to protect our body against injury and damage-induced infection.
Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was the first domesticated growth in South America.
Black or common beans with abundant phytochemicals may be considered functional foods in attenuated pro-inflammatory expression induced by immunity during injured, a respectable institute postulated.
In a randomized, controlled, crossover trial of 12 adults with metabolic syndrome (MetS) who consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) study, researchers found that blood sample collection before (fasting) and five hours after the meal, black bean intake group showed a significant expression of plasma antioxidant capacity and inflammatory cytokines in response to meals differences over time.
This result showed strong support for black bean intake reduced levels of oxidative stress-induced inflammation and enhanced production of antioxidants.
Dr. Reverri EJ the lead researcher said, " Inclusion of black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints".
In other words, adding a portion of black bean may improve insulin resistance and induce antioxidant activity to modify the risk and treatment of inflammatory metabolic syndrome.
In colon inflammation triggered by high-fat diet (HD)-induced obesity in mice, mice fed with black bean showed a remarkable effect in a reduced pro-inflammatory expression such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, by attenuating changes associated with HD-induced colon inflammation.
Additionally, black bean-fed mice also demonstrated a significant improvement of antioxidants through modulated colon mRNA expression and reduced macrophage infiltration into adipose tissue, causing inflammation.
Furthermore, Dr. the lead author expressed, " BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-κB to decrease the production of proinflammatory cytokines".
Another study in support of the efficacy of black beans in ameliorated inflammation suggested that bean diets reduced not only mRNA expression of exhibited production of colonic inflammatory cytokines (IL-6, IL-9, IFN-γ, and IL-17A) and increased anti-inflammatory IL-10 (P< 0·05), but also systemically reduced circulating cytokines (IL-1β, TNFα, IFNγ, and IL-17A, P< 0·05) and dextran sodium sulfate-induced oxidative stress and colitis in animal model.
The findings suggested that black beans may be used as a functional food for the prevention of inflammation after body injury or damage by reduced levels of pro-inflammatory and increased levels of anti-inflammatory cytokines.
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Sources
(1) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,7.(PubMed)
(2) Black Adzuki Bean (Vigna angularis) Attenuates High-Fat Diet-Induced Colon Inflammation in Mice by Yook JS1, Kim KA2, Kim M1, Cha YS1.(PubMed)
(3) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA1. (PubMed)
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