Kyle J. Norton
A chemosensitivity assay is a test that measures the number of tumor cells killed by chemotherapy.
The aim of the test is to find the best chemo drugs for the treatment of cancer.
Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissues and organs.
At the early stage due to the very small size of the tumor, most cancers are asymptomatic. However, at the advanced stage, cancer not only can induce general symptoms such as gastrointestinal discomfort, unintended weight loss, fatigue, and loss but also lead to specific symptoms, such as localized bleeding and pain, depending on the location of the cancer.
Also, at this stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis through the circulation of blood and fluids.
Some cancers can be slow-growth, including prostate and colon cancer. Primary cancer at stages 0 and 1 may not induce any symptoms.
According to the statistic provided by the American Cancer Society, in the US in 2019, approximately 1,762,450 new cancer cases will be diagnosed and 606,880 deaths are a result from cancer.
Furthermore, in the age perspective, older adults although accounted for only 8% of all cases diagnosed in the US, have a 17% mortality rate compared to other age groups.
As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.
The 5 years survival rate is totally depending on the stage of cancer diagnosed. The early diagnosed stage has the highest survival rate compared to other later stages.
Cisplatin is a chemotherapy drug given by Sclerotherapy used in conventional medicine for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors, and neuroblastoma.
Cisplatin has been found to induce adverse effects, including nausea and vomiting, diarrhea, temporary hair loss, loss inability to taste food, dry mouth, dark urine, and decreased sweating,
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
In finding a potential chemical compound with inhibition of chemotherapy side effects and chemosensitivity, researchers compared the effect of polymeric nanoparticles utilized to co-deliver a water-soluble CDDP derivative, poly(γ,l-glutamic acid)-CDDP conjugate and a naturally occurring compound derived from broccoli, sulforaphane (SFN) on chemo drug cisplatin (CDDP).
Compared with the combinational treatment of CDDP and SFN, the nanoparticles were more effectively internalized and significantly reduced GSH content in breast cancer cells, observed by the increase of DNA-bound Pt and DNA damage-induced apoptosis.
In other words, the combination is more effective than the use of the chemo drug alone due to its ability to penetrate deeper into the cancer cells.
Furthermore, in an orthotopic breast cancer model, the nanoparticles achieved a significantly higher tumor accumulation by enhancing the permeability and retention of EPR-mediated tumor targeting and exhibited a more powerful antitumor activity.
The nano-enhanced chemotherapy also showed higher content of GSH in the liver cancer model.
Collectively, researchers said, "this sulforaphane-based nano strategy holds great promise to enhance the sensitivity and therapeutic efficacy of Pt-based chemotherapy
Taken together, broccoli processed with a high amount of sulforaphane used in a combination of chemo drugs may be considered adjunct therapy for the treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of sulforaphane in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity by Xu Y1,2,3, Han X1,2,4, Li Y1,2, Min H1, Zhao X1,2, Zhang Y1,2, Qi Y5, Shi J1,2, Qi S6, Bao Y7, Nie G. (PubMed)
Tuesday, 8 August 2023
3,3'-Diindolylmethane Inhibits the Pathways and Promotes Antioxidant Enzymes Associated with a Reduced Risk of #ChronicLiverDisease
Kyle J. Norton
Chronic liver diseases are a medical condition that causes reduced function of the liver. In a serious case, chronic liver disease can lead to liver failure.
In other words, chronic liver diseases are liver diseases that last more than 6 months, including liver viral inflammation, liver cirrhosis, and hepatocellular carcinoma.
The liver is a large organ in the human body that filters out the blood which comes from the intestines before passing them to other parts of the body.
The largest organ also produces cholesterol to aid digestion, build a strong cell wall and produce steroids hormones and vitamin D.
According to the statistics provided by the UK, liver diseases are ranked as the fifth most common cause of death in the UK and have a steady tendency to increase over the years.
In the US, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease which affects over 100 100 million Americans.
Non-alcoholic fatty liver disease is a medical condition that caused fat accumulated in the liver over time probably due to poor diet and physical inactivity. The disease is one of the major causes of cirrhosis associated with liver cancer and liver failure.
The most common symptoms of chronic liver disease include loss of appetite, jaundice, persistent itching, fluid buildup in the belly, vomiting blood caused by the bleeding of often from bleeding in the esophagus.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
With an aim to discover a potent ingredient that processes liver protective effect, researchers investigated the effect of indoles, including indole-3-carbinol (I3C) and its derivatives I3C polymerizes into 3, 3- diindolylmethane (DIM) on chronic liver disease.
In vivo and vitro, indoles showed to regulate transcriptional factors and their respective signaling pathways associated with the production of proteins involved in the pro-inflammatory expression.
Furthermore, indoles also promoted the production of antioxidant enzymes against overexpression of levels of free radicals induced oxidative stress.
Moreover, the administration of indoles in vivo and in vitro also inhibited microRNA to influence the activation, proliferation, and apoptosis of target liver cells.
In other words, indoles protect the liver integrity by modulating the enzymes involved in hepatitis viral replication, lipogenesis, and the metabolism of ethanol and some hepatotoxicity.
Additionally, the bioactive compound was also found to process immunomodulatory biofunction in improving non-alcoholic steatohepatitis.
Overall, the indole liver-protective effects were attributed to its function as anti-inflammatory cytokines and chemokines to reduce microbial-induced liver injury inhibitors.
Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".
Taken altogether, indoles, including 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered supplements for the prevention and treatment of chronic liver disease pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance by Liu Y1, She W1, Wang F1, Li J2, Wang J1, Jiang W. (PubMed)
(2) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)
Chronic liver diseases are a medical condition that causes reduced function of the liver. In a serious case, chronic liver disease can lead to liver failure.
In other words, chronic liver diseases are liver diseases that last more than 6 months, including liver viral inflammation, liver cirrhosis, and hepatocellular carcinoma.
The liver is a large organ in the human body that filters out the blood which comes from the intestines before passing them to other parts of the body.
The largest organ also produces cholesterol to aid digestion, build a strong cell wall and produce steroids hormones and vitamin D.
According to the statistics provided by the UK, liver diseases are ranked as the fifth most common cause of death in the UK and have a steady tendency to increase over the years.
In the US, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease which affects over 100 100 million Americans.
Non-alcoholic fatty liver disease is a medical condition that caused fat accumulated in the liver over time probably due to poor diet and physical inactivity. The disease is one of the major causes of cirrhosis associated with liver cancer and liver failure.
The most common symptoms of chronic liver disease include loss of appetite, jaundice, persistent itching, fluid buildup in the belly, vomiting blood caused by the bleeding of often from bleeding in the esophagus.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
With an aim to discover a potent ingredient that processes liver protective effect, researchers investigated the effect of indoles, including indole-3-carbinol (I3C) and its derivatives I3C polymerizes into 3, 3- diindolylmethane (DIM) on chronic liver disease.
In vivo and vitro, indoles showed to regulate transcriptional factors and their respective signaling pathways associated with the production of proteins involved in the pro-inflammatory expression.
Furthermore, indoles also promoted the production of antioxidant enzymes against overexpression of levels of free radicals induced oxidative stress.
Moreover, the administration of indoles in vivo and in vitro also inhibited microRNA to influence the activation, proliferation, and apoptosis of target liver cells.
In other words, indoles protect the liver integrity by modulating the enzymes involved in hepatitis viral replication, lipogenesis, and the metabolism of ethanol and some hepatotoxicity.
Additionally, the bioactive compound was also found to process immunomodulatory biofunction in improving non-alcoholic steatohepatitis.
Overall, the indole liver-protective effects were attributed to its function as anti-inflammatory cytokines and chemokines to reduce microbial-induced liver injury inhibitors.
Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".
Taken altogether, indoles, including 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered supplements for the prevention and treatment of chronic liver disease pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance by Liu Y1, She W1, Wang F1, Li J2, Wang J1, Jiang W. (PubMed)
(2) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)
Vitex Negundo, a Five-Leaved Chaste Tree Extract Processes Anti-Lipase and Anti-Propionibacterium Acne Activity, According to Studies
Kyle J. Norton
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region. It has been used in herbal medicine for thousands of years as an aphrodisiac herb and is considered as Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time. There was a report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,
Propionibacterium acne is a type of acne due to infection of aerotolerant anaerobic, Gram-positive bacterium (rod) or as a result of chronic blepharitis and endophthalmitis.
Vitex agnus-castus has long been used for the treatment of hormonally induced acne in herbal medicine(1) with mild or no adverse side effects (2). Vitex negundo, a five-leaved chaste tree extract, according to the study by The Institute of Science, India, showed significant inhibition of lipase activity and a number of P. acne(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) The genus Vitex: A review by Rani A1, Sharma A2. (PubMed)
(2) Vitex agnus castus: a systematic review of adverse events by Daniele C1, Thompson Coon J, Pittler MH, Ernst E.(PubMed)
(3) Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants by Patil V1, Bandivadekar A, Debjani D.(PubMed)
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region. It has been used in herbal medicine for thousands of years as an aphrodisiac herb and is considered as Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time. There was a report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,
Propionibacterium acne is a type of acne due to infection of aerotolerant anaerobic, Gram-positive bacterium (rod) or as a result of chronic blepharitis and endophthalmitis.
Vitex agnus-castus has long been used for the treatment of hormonally induced acne in herbal medicine(1) with mild or no adverse side effects (2). Vitex negundo, a five-leaved chaste tree extract, according to the study by The Institute of Science, India, showed significant inhibition of lipase activity and a number of P. acne(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) The genus Vitex: A review by Rani A1, Sharma A2. (PubMed)
(2) Vitex agnus castus: a systematic review of adverse events by Daniele C1, Thompson Coon J, Pittler MH, Ernst E.(PubMed)
(3) Inhibition of Propionibacterium acnes lipase by extracts of Indian medicinal plants by Patil V1, Bandivadekar A, Debjani D.(PubMed)
#Herbal #Cinnamon and Its #EssentialOil Process a Strong Anti Fungal and Bacterial Infection Activties, According to Studies
Kyle J. Norton
The topical use of essential oil and intake of cinnamon in patients are found to express antimicrobial effects.
The essential oil found from cinnamomum zeylanicum, in influenza and post-influenza bacterial pneumonia infections resisted conventional antimicrobial agents and inhibited effectively against H1N1 and HSV1 viruses.
According to the study by the Kings and St Thomas's Hospital, natural essential oils extracted from cinnamon expressed antimicrobial activity among three oils against Escherichia coli, Staphylococcus aureus , Aspergillus oryzae , and Penicillium digitatum.
Cinnamon is a spice derived from the inner bark of the tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as an anti-fungal and bacterial levels, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
Dr. Liu Q, the lead author at the Liu Q, said," Cinnamon,... possessed significant antibacterial and antifungal activities against food spoilage bacteria like Bacillus subtilis and Pseudomonas fluorescens, pathogens like Staphylococcus aureus and Vibrio parahaemolyticus, harmful fungi like Aspergillus flavus".
In vitro, trans-cinnamaldehyde showed to inhibit Clostridium difficile infection in the spore-forming bacterium.
Cinnamon and its essential oil may be the natural agent in use for the prevention and treatment of microbial infection. Intake of whole herbs and supplements should be taken with care. Overdoses have been seen to induce toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Synergistic antimicrobial activities of natural essential oils with chitosan films by Wang L1, Liu F, Jiang Y, Chai Z, Li P, Cheng Y, Jing H, Leng X.(PubMed)
(2) Antibacterial and Antifungal Activities of Spices by Liu Q1, Meng X2, Li Y3, Zhao CN4, Tang GY5, Li HB6,7.(PubMed)
(3) Antimicrobial activity of natural products against Clostridium difficile in vitro by Roshan N1, Riley TV1,2,3,4, Hammer KA1.(PubMed)
(4) Antibacterial, antifungal, and antiviral effects of three essential oil blends by Brochot A1, Guilbot A1, Haddioui L2, Roques C2,3.(PubMed)
The topical use of essential oil and intake of cinnamon in patients are found to express antimicrobial effects.
The essential oil found from cinnamomum zeylanicum, in influenza and post-influenza bacterial pneumonia infections resisted conventional antimicrobial agents and inhibited effectively against H1N1 and HSV1 viruses.
According to the study by the Kings and St Thomas's Hospital, natural essential oils extracted from cinnamon expressed antimicrobial activity among three oils against Escherichia coli, Staphylococcus aureus , Aspergillus oryzae , and Penicillium digitatum.
Cinnamon is a spice derived from the inner bark of the tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as an anti-fungal and bacterial levels, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
Dr. Liu Q, the lead author at the Liu Q, said," Cinnamon,... possessed significant antibacterial and antifungal activities against food spoilage bacteria like Bacillus subtilis and Pseudomonas fluorescens, pathogens like Staphylococcus aureus and Vibrio parahaemolyticus, harmful fungi like Aspergillus flavus".
In vitro, trans-cinnamaldehyde showed to inhibit Clostridium difficile infection in the spore-forming bacterium.
Cinnamon and its essential oil may be the natural agent in use for the prevention and treatment of microbial infection. Intake of whole herbs and supplements should be taken with care. Overdoses have been seen to induce toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Synergistic antimicrobial activities of natural essential oils with chitosan films by Wang L1, Liu F, Jiang Y, Chai Z, Li P, Cheng Y, Jing H, Leng X.(PubMed)
(2) Antibacterial and Antifungal Activities of Spices by Liu Q1, Meng X2, Li Y3, Zhao CN4, Tang GY5, Li HB6,7.(PubMed)
(3) Antimicrobial activity of natural products against Clostridium difficile in vitro by Roshan N1, Riley TV1,2,3,4, Hammer KA1.(PubMed)
(4) Antibacterial, antifungal, and antiviral effects of three essential oil blends by Brochot A1, Guilbot A1, Haddioui L2, Roques C2,3.(PubMed)
#CruciferousVegetables Inversely Are Associated with the Risk of Total Mortality Rate in Patients with Cardiovascular Diseases
Kyle J. Norton
A cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.
The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
What causes plaques building up in the wall of the arteries is debatable.
Researchers do not why people who have the same health conditions, family history, and diet pattern, are susceptible to the early onset of cardiovascular disease while others do not.
According to the John Hopkins statistics, approximately 84 million people in the US suffer from some form of cardiovascular disease, causing about 2,200 deaths a day, averaging one death every 40 seconds.
Sadly to now that almost one out of every three deaths results from cardiovascular disease.
Epidemiologically, certain risk factors are found to associate with the onset of the condition, including lack of exercise, diabetes, use of tobacco, gender, genetic preposition, and excessive alcohol drinking.
One of the most common and preventable risk factors has been under intensified debate in the scientific community. If a poor diet pattern and lifestyle can facilitate the onset of the disease, then a healthy diet choice and lifestyle with moderate exercise should provide a strong effect in the prevention and treatment of cardiovascular disease.
In other words, by replacing the Western diet characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks and a dietary risk factor for CVD with the traditional diet characterized by high in fruits and vegetables and less in red meat and processed foods, cardiovascular disease is preventable.
Cardiovascular disease (CVD) is a leading disease to cause of death of 840,768 deaths (635,260 cardiac) in 2016 in the United States.
From 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for reducing the mortality rate of cardiovascular diseases, researchers compared cruciferous vegetables, noncruciferous vegetables, total vegetables, and total fruit intake with risk of all-cause and cause-specific mortality.
The study included a total of 134,796 Chinese adults who participated in 2 population-based, prospective cohort studies in the Shanghai Women's Health Study and the Shanghai Men's Health Study.
According to the validated food-frequency questionnaires, returned from the participants,
* Over the time of the study, 3442 deaths among women during a mean follow-up of 10.2 y and 1951 deaths among men during a mean follow-up of 4.6 y.
*Although fruit and vegetable intake was inversely associated with risk of total mortality in both women and men, and a dose-response pattern, cruciferous vegetable intake showed the most strong protective effects against mortality.
* The inverse associations of all fruits and vegetables intake primarily related only to cardiovascular disease mortality but not to cancer mortality.
Based on the results, researchers said, "Our findings support recommendations to increase consumption of vegetables, particularly cruciferous vegetables, and fruit to promote cardiovascular health and overall longevity".
Taken together, cruciferous vegetables may be considered functional remedies for the prevention of total and cardiovascular disease mortality, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality by Zhang X1, Shu XO, Xiang YB, Yang G, Li H, Gao J, Cai H, Gao YT,
Zheng W. (PubMed)
A cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.
The 3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
What causes plaques building up in the wall of the arteries is debatable.
Researchers do not why people who have the same health conditions, family history, and diet pattern, are susceptible to the early onset of cardiovascular disease while others do not.
According to the John Hopkins statistics, approximately 84 million people in the US suffer from some form of cardiovascular disease, causing about 2,200 deaths a day, averaging one death every 40 seconds.
Sadly to now that almost one out of every three deaths results from cardiovascular disease.
Epidemiologically, certain risk factors are found to associate with the onset of the condition, including lack of exercise, diabetes, use of tobacco, gender, genetic preposition, and excessive alcohol drinking.
One of the most common and preventable risk factors has been under intensified debate in the scientific community. If a poor diet pattern and lifestyle can facilitate the onset of the disease, then a healthy diet choice and lifestyle with moderate exercise should provide a strong effect in the prevention and treatment of cardiovascular disease.
In other words, by replacing the Western diet characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks and a dietary risk factor for CVD with the traditional diet characterized by high in fruits and vegetables and less in red meat and processed foods, cardiovascular disease is preventable.
Cardiovascular disease (CVD) is a leading disease to cause of death of 840,768 deaths (635,260 cardiac) in 2016 in the United States.
From 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential remedy for reducing the mortality rate of cardiovascular diseases, researchers compared cruciferous vegetables, noncruciferous vegetables, total vegetables, and total fruit intake with risk of all-cause and cause-specific mortality.
The study included a total of 134,796 Chinese adults who participated in 2 population-based, prospective cohort studies in the Shanghai Women's Health Study and the Shanghai Men's Health Study.
According to the validated food-frequency questionnaires, returned from the participants,
* Over the time of the study, 3442 deaths among women during a mean follow-up of 10.2 y and 1951 deaths among men during a mean follow-up of 4.6 y.
*Although fruit and vegetable intake was inversely associated with risk of total mortality in both women and men, and a dose-response pattern, cruciferous vegetable intake showed the most strong protective effects against mortality.
* The inverse associations of all fruits and vegetables intake primarily related only to cardiovascular disease mortality but not to cancer mortality.
Based on the results, researchers said, "Our findings support recommendations to increase consumption of vegetables, particularly cruciferous vegetables, and fruit to promote cardiovascular health and overall longevity".
Taken together, cruciferous vegetables may be considered functional remedies for the prevention of total and cardiovascular disease mortality, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality by Zhang X1, Shu XO, Xiang YB, Yang G, Li H, Gao J, Cai H, Gao YT,
Zheng W. (PubMed)
#GreenPeas Enhance the Digestive Function by Improving the Enzymatic Activity of Large Gut Microbiota in Flavors of the Good Bacteria
Kyle J. Norton
The digestive system including the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body's normal function by providing nutrients and fluids to the body and remove waste through the secretary system.
Digestion is a process of the digestive system by breaking out food after food intake through mechanical and enzymatic action.
Indigestion, on the other hand, is a symptom of another digestive disease, including GERD. Most cases of indigestion not caused by underlying diseases can be resolved quickly.
People with indigestion experience symptoms differently. Some may feel the symptoms of occasionally while others may feel often and daily.
There are a number of risk factors associated with digestive disorders including bacterial and/or viral infection, inflammation, lactase deficiency, anti-inflammatory drugs and certain conditions such as ruptured or perforated organs, muscle dysfunction, and gallstones.
However, some researchers suggested that there is a strong correlation between the risk of digestive disorders in obese patients.
Dr. Su Youn Nam, in the investigation of obesity-related digestive diseases, wrote, "Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett’s esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer".
And, "Although obesity-related esophageal diseases are associated with altered mechanical and humoral factors, other obesity-related digestive diseases seem to be associated with obesity-induced altered circulating levels of adipocytokines and insulin resistance".
The findings strongly indicated the risk of digestive disorder in obese is substantially higher compared to healthy weight individuals.
Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayas Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
On finding a potent ingredient for the treatment of digestive diseases, researchers investigated the effects of soybean meal (SBM) substitution by a mixture of rapeseed meal (RSM), white lupine seeds (WLS) and pea seeds (PS) on gastrointestinal function in Hyplus rabbits.
Selected Hyplus rabbits were fed either a control diet (SBM15) containing 15% SBM, or diet SBM7.5 containing 7.5% SBM, 5% RSM, 4% WLS and 3% PS. In diet SBM0 or diet SBM0, SBM completely was replaced by RSM, WLS, and PS (10%, 8%, and 6%, respectively).
Based on the tested analysis, the experimental diets did not cause significant differences in performance parameters evaluated in vivo and post-mortem, and in the nutrient and energy digestibility of nitrogen retention.
However, the change of enzymatic activity of large gut microbiota in flavors of the good bacteria was found to have a similar effect in the comparison of diet SBM and the mixture of RSM, WLS, and PS.
In other words, pea seeds (PS) used a combination with rapeseed meal (RSM) and lupine seeds (WLS) processes a significant effect in balancing the levels of microbiota in the promotion of digestive functioning.
Taken together, green peas used alone or combined with other healthy food may be considered a remedy for the promotion of gastrointestinal health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of rapeseed meal and legume seeds as substitutes for soybean meal on productivity and gastrointestinal function in rabbits by Gugołek A1, Juśkiewicz J2, Strychalski J1, Zwoliński C1, Żary-Sikorska E3, Konstantynowicz M. (PubMed)
(2) Obesity-Related Digestive Diseases and Their Pathophysiology by Su Youn Nam. (PMC)
The digestive system including the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body's normal function by providing nutrients and fluids to the body and remove waste through the secretary system.
Digestion is a process of the digestive system by breaking out food after food intake through mechanical and enzymatic action.
Indigestion, on the other hand, is a symptom of another digestive disease, including GERD. Most cases of indigestion not caused by underlying diseases can be resolved quickly.
People with indigestion experience symptoms differently. Some may feel the symptoms of occasionally while others may feel often and daily.
There are a number of risk factors associated with digestive disorders including bacterial and/or viral infection, inflammation, lactase deficiency, anti-inflammatory drugs and certain conditions such as ruptured or perforated organs, muscle dysfunction, and gallstones.
However, some researchers suggested that there is a strong correlation between the risk of digestive disorders in obese patients.
Dr. Su Youn Nam, in the investigation of obesity-related digestive diseases, wrote, "Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett’s esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer".
And, "Although obesity-related esophageal diseases are associated with altered mechanical and humoral factors, other obesity-related digestive diseases seem to be associated with obesity-induced altered circulating levels of adipocytokines and insulin resistance".
The findings strongly indicated the risk of digestive disorder in obese is substantially higher compared to healthy weight individuals.
Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayas Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
On finding a potent ingredient for the treatment of digestive diseases, researchers investigated the effects of soybean meal (SBM) substitution by a mixture of rapeseed meal (RSM), white lupine seeds (WLS) and pea seeds (PS) on gastrointestinal function in Hyplus rabbits.
Selected Hyplus rabbits were fed either a control diet (SBM15) containing 15% SBM, or diet SBM7.5 containing 7.5% SBM, 5% RSM, 4% WLS and 3% PS. In diet SBM0 or diet SBM0, SBM completely was replaced by RSM, WLS, and PS (10%, 8%, and 6%, respectively).
Based on the tested analysis, the experimental diets did not cause significant differences in performance parameters evaluated in vivo and post-mortem, and in the nutrient and energy digestibility of nitrogen retention.
However, the change of enzymatic activity of large gut microbiota in flavors of the good bacteria was found to have a similar effect in the comparison of diet SBM and the mixture of RSM, WLS, and PS.
In other words, pea seeds (PS) used a combination with rapeseed meal (RSM) and lupine seeds (WLS) processes a significant effect in balancing the levels of microbiota in the promotion of digestive functioning.
Taken together, green peas used alone or combined with other healthy food may be considered a remedy for the promotion of gastrointestinal health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of rapeseed meal and legume seeds as substitutes for soybean meal on productivity and gastrointestinal function in rabbits by Gugołek A1, Juśkiewicz J2, Strychalski J1, Zwoliński C1, Żary-Sikorska E3, Konstantynowicz M. (PubMed)
(2) Obesity-Related Digestive Diseases and Their Pathophysiology by Su Youn Nam. (PMC)
#Broccoli or #BroccoliSprouts' Sulforaphane Inhibits Oxidativestress but Not Affecting Thyroid Hormones or Thyroid Autoimmune Disease
Kyle J. Norton
Thyroid disease is a medical condition that causes a malfunction of the thyroid.
Hyperthyroidism is a condition in which the thyroid gland is overactive and produces too much thyroid hormones.
The most common symptoms of hyperthyroidism are excessive sweating, heat intolerance, increased bowel movements, shaking, nervousness, agitation, anxiety, rapid heart rate, palpitations, irregular heart rate, weight loss, fatigue, weakness...
Hypothyroidism is a condition in which the thyroid gland is underactive and produces very little thyroid hormones.
Symptoms of hypothyroidism are depended on the severe stage of the disease. As it progresses slowly over the years such as weight gain and fatigue, vitiligo and alopecia areata, chronic constipation, urticaria and puffiness of hands and feet, yellow ivory skin, coarse rough dry skin, alopecia periorbital edema, amenorrhea, dyspareunia, PCO, PMS and breast tenderness, menstrual irregularities and infertility,...
Thyroid toxicity that affects the function of the thyroid gland not only causes thyroid dysfunction but also induces thyroid autoimmune disease.
According to Dr. Catherine Sutcliffe, the lead scientist in the study of "Endocrine Disruption of Thyroid Function" wrote, "The common factor in the direct thyroid toxicity mechanisms so far outlined is the reduction of thyroid hormone production and secretion. The reduction of thyroid hormones (T4 or T3) results in compensatory increased secretion of TSH due to the concomitant diminution of feedback control (see Figure 11.3)".
And, "It is important to note that increased TSH stimulation of the thyroid produces the same histopathological effects irrespective of the mechanism by which TSH is increased including thyroid growth evidenced by increased size and weight".
There are a number of causes of thyroid toxicity including short and long-term intake of some medications (sunitinib has been found to cause thrombocytopenia and hypoglycemia in 62 patients) and xenobiotics.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
In finding thyroidal toxicity.of sulforaphane, a redox-active natural product present in cruciferous vegetables like broccoli. For broccoli sprouts, researchers examined the effect of the phytochemical sulforaphane effect on Nrf2 (NFE2-related factor 2) that leads to thyroid dysfunction or thyroid autoimmune disease.
According to the results of the biochemical measures of thyroid function and thyroid autoimmunity in 45 female participants in a randomized clinical trial at baseline and after 84 days of beverage administration, researchers found that
* Broccoli sprout-derived products show promising activity for the prevention of oxidative stress-related diseases.
* Sulforaphane did not affect the serum levels of thyroid-stimulating hormone, free thyroxine, and thyroglobulin.
* More importantly, sulforaphane does not affect thyroid autoimmunity status.
Based on the findings, researchers said, "These results provide evidence in favor of the safety of chemoprevention strategies that target the activation of Nrf2 to protect against environmental exposures and other oxidative stress-related pathologies".
Taken altogether, Broccoli sprouts may be safe for the prevention and treatment of oxidative stress-related diseases without causing thyroidal toxicity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial by Chartoumpekis DV1, Ziros PG2, Chen JG3, Groopman JD4, Kensler TW1, Sykiotis GP. (PubMed)
(2) Thyroid Toxicity (Science Direct)
Thyroid disease is a medical condition that causes a malfunction of the thyroid.
Hyperthyroidism is a condition in which the thyroid gland is overactive and produces too much thyroid hormones.
The most common symptoms of hyperthyroidism are excessive sweating, heat intolerance, increased bowel movements, shaking, nervousness, agitation, anxiety, rapid heart rate, palpitations, irregular heart rate, weight loss, fatigue, weakness...
Hypothyroidism is a condition in which the thyroid gland is underactive and produces very little thyroid hormones.
Symptoms of hypothyroidism are depended on the severe stage of the disease. As it progresses slowly over the years such as weight gain and fatigue, vitiligo and alopecia areata, chronic constipation, urticaria and puffiness of hands and feet, yellow ivory skin, coarse rough dry skin, alopecia periorbital edema, amenorrhea, dyspareunia, PCO, PMS and breast tenderness, menstrual irregularities and infertility,...
Thyroid toxicity that affects the function of the thyroid gland not only causes thyroid dysfunction but also induces thyroid autoimmune disease.
According to Dr. Catherine Sutcliffe, the lead scientist in the study of "Endocrine Disruption of Thyroid Function" wrote, "The common factor in the direct thyroid toxicity mechanisms so far outlined is the reduction of thyroid hormone production and secretion. The reduction of thyroid hormones (T4 or T3) results in compensatory increased secretion of TSH due to the concomitant diminution of feedback control (see Figure 11.3)".
And, "It is important to note that increased TSH stimulation of the thyroid produces the same histopathological effects irrespective of the mechanism by which TSH is increased including thyroid growth evidenced by increased size and weight".
There are a number of causes of thyroid toxicity including short and long-term intake of some medications (sunitinib has been found to cause thrombocytopenia and hypoglycemia in 62 patients) and xenobiotics.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
In finding thyroidal toxicity.of sulforaphane, a redox-active natural product present in cruciferous vegetables like broccoli. For broccoli sprouts, researchers examined the effect of the phytochemical sulforaphane effect on Nrf2 (NFE2-related factor 2) that leads to thyroid dysfunction or thyroid autoimmune disease.
According to the results of the biochemical measures of thyroid function and thyroid autoimmunity in 45 female participants in a randomized clinical trial at baseline and after 84 days of beverage administration, researchers found that
* Broccoli sprout-derived products show promising activity for the prevention of oxidative stress-related diseases.
* Sulforaphane did not affect the serum levels of thyroid-stimulating hormone, free thyroxine, and thyroglobulin.
* More importantly, sulforaphane does not affect thyroid autoimmunity status.
Based on the findings, researchers said, "These results provide evidence in favor of the safety of chemoprevention strategies that target the activation of Nrf2 to protect against environmental exposures and other oxidative stress-related pathologies".
Taken altogether, Broccoli sprouts may be safe for the prevention and treatment of oxidative stress-related diseases without causing thyroidal toxicity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial by Chartoumpekis DV1, Ziros PG2, Chen JG3, Groopman JD4, Kensler TW1, Sykiotis GP. (PubMed)
(2) Thyroid Toxicity (Science Direct)
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