#Healthy Food #Onion's #Quercetin and #OnioninA (ONA) Exert #Cardioprotection Against the Risk of #CardiovascularDisease, Researchers Say

Kyle J. Norton

Cardiovascular disease (CVD) is a class of diseases associated with blood vessels caused by narrowed or blocked blood vessels that can lead to a heart attack and stroke.

The heart formed part of the circulatory system is a muscular organ pumping blood through the blood vessels to nourish the cells, tissues, and organs in the body.

Heart disease is a class of conditions associated with reduced function of the heart due to damage to the structure, including the heart muscle.

According to the statistics provided by the WHO, CVD is the number 1 cause of death globally. In other words, 31% of all global deaths are CVD.

Stroke is an emergency event caused by a blood vessel in the brain ruptures that lead to deprive oxygen in the brain cells causing the death of neurons.

According to the statistics, stroke is a leading cause of serious, long-term disability in the United States. Every year, approximately 795,000 people suffer a stroke. About 600,000 of these are first attacks, and 185,000 are recurrent attacks.

Believe it or not, 3/4 cases of stroke are in patients over 65 years of age.

There is no single cause of CVD. The most prevalent factors associated with the risk of CVD are
aging, male gender, ethnicity, smoking, metabolic syndrome including high blood pressure, sugar, and cholesterol, physical inactivity, overweight, and obesity.

However, some researchers suggested that the increased metabolic syndrome at the alarming rate correlated to the high rate of CVD onset over the past few decades probably is associated with the promotion of the Western diet in the US.

Dr. Mirmiran P, the lead scientist wrote, " Two major dietary patterns, Western and traditional, were identified. During a mean of 4.7 ± 1.4 years of follow-up, 57 participants experienced CVD-related events... In the fully adjusted model, we observed an increased risk of CVD-related events in the highest compared to the lowest tertile category of Western dietary pattern score (HR = 2.07, 95% CI = 1.03-4.18, P for trend = 0.01)

And, " the Western dietary pattern, characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks, is a dietary risk factor for CVD in the Iranian population".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

In finding a potent ingredient that processes cardioprotection researchers examined the Allium species, their extracts, and the chemical constituents for possible effects on cardiovascular disease risk factors.

Quercetin, a type of flavonoid found in onion-induced cardioprotection against the risk factors of cardiovascular diseases, including ischemia-reperfusion injury, cardiotoxicity, and hypertension.

In patients with atherosclerotic disease, certain formulations of garlic and/or onion protected the arteries by inhibiting the formation of plaques, and other unfavorable parameters associated with the disease onset.

Garlic and onion also exerted a significant activity against blood coagulability, a condition found in patients with cardiovascular diseases.

Risk factors associated with metabolic syndromes such as hyperlipidemia, hypertension, and hyperglycemia were also inhibited by the administration of garlic and onion in vitro, vivo, and a number of small-size human studies.

However, acute and chronic ingestion of large amounts of these plants or their extracts may cause liver and kidney toxicity.

Taken altogether, onion processed with a higher amount of Onionin A (ONA) may be considered a remedy for the prevention and treatment of cardiovascular diseases, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cardiovascular Disease: A Target for the Pharmacological Effects of Quercetin by Gormaz JG, Quintremil S, Rodrigo R. (PubMed)
(2) Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease by Kendler BS. (PubMed)
(3) Western dietary pattern increases the risk of cardiovascular disease in Iranian adults: a prospective population-based study by Mirmiran P1, Bahadoran Z2, Vakili AZ3, Azizi F. (PubMed)

#Cucumber's Freeze-Dried Aqueous #Extract That inhibits Esophageal Cancer by Inducing Cell Cycle Arrest and Cytotoxicity, Acccording to Studies

Kyle J. Norton

Esophageal cancer is a chronic and medical condition arisen from the esophagus due to the alternation of cell DNA.

Most cases of esophageal cancer start in the cell on the surface of the inner lining of the esophagus between the throat and the stomach. At the early stage, due to the very small size of the tumor, most patients are asymptomatic.

As the tumor continues to grow, patients may experience symptoms of difficulty swallowing, persistent chest pain and pressure, pain-burning sensation, coughing or hoarseness, and heartburn.

If you persistently experience chronic acid reflux, accompanied by some of the aforementioned symptoms, you should check with your doctor immediately to rule out the possibility of esophageal cancer.

Some patients may also vomit blood if the tumor has pressed onto the nearby blood vessels.


At the advanced stage, the primary cancer cell can also travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

According to the statistics, in the US, approximately 17,650 adults (13,750 men and 3,900 women) in the United States will be diagnosed with esophageal cancer this year, accounting for 1% of cancers diagnosed.

Although there are many risk factors associated with the onset of the disease, some researchers suggested patients with chronic gastroesophageal reflux disease (GERD) are found to have a strong implication on the disease onset.

Dr. Shaheen N, the lead scientist at the University of North Carolina-Chapel Hil, wrote, "Gastroesophageal reflux disease (GERD) is a risk factor for adenocarcinoma of the esophagus, rare cancer whose incidence is increasing".

However, "Strong evidence supports the association of GERD and adenocarcinoma of the esophagus; however, the risk of cancer in any given individual with GERD is low".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to discover a potential ingredient for the treatment of esophageal cancer, researchers investigated the possible cytotoxic effect of freeze-dried aqueous extract of E. elaterium fruit on KYSE30 (human esophageal squamous cell carcinoma).

The study included the free dried aqueous extract of the fruits of E. elaterium incubated for 24, 48, and 72 h. on KYSE30 cancer cell lines.

The extracts showed a significant effect in the inhibition of KYSE30 cell line at IC(50) values at concentrations of 500, 150, and 125 μg/ml after 24, 48, and 72 h, respectively.


According to the EB/AO staining, the extract showed an increase in apoptotic cells of the KYSE30 cell line.

Furthermore, the free-dried aqueous extract of the fruits of E. elaterium exerted a significant increase in cell density at the G2/M phase before inducing cell cycle arrest, according to the cell cycle analysis.

Based on the findings, researchers suggested that the freeze-dried aqueous extract of E. elaterium fruit has a cytotoxic effect on esophageal cancer cell lines via the induction of apoptosis.

Dr. Bohlooli S, the lead scientist wrote, " It seems that several compounds are possibly responsible for the cytotoxic effect of the extract".

In other words, several compounds in the extract worked synergistically to exhibit cytotoxicity against the tested cancer cell line.

Taken together, cucumber may be considered supplements for the prevention and treatment of esophageal cancer, pending the confirmation of the larger sample size and multicenter human study.


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Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastric adenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines by Bohlooli S1, Jafari N, Jahed S. (PubMed)
(2) Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review by Shaheen N1, Ransohoff DF. (PubMed)

#Papaya's #Hexane #Extract and #Dichloromethane #Extract Process Anti-Hypertensive Activity, Researchers Show

Kyle J. Norton

Papaya may be considered a natural whole food for the prevention and treatment of hypertension, some scientists suggested.
Hypertension is another term for abnormally high blood pressure in the arteries.

Although h blood pressure usually does not cause symptoms some patients with the syndrome may experience dizziness and light head.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

Underlying medical conditions such as kidney disease and long-term stress are associated with high blood pressure. Epidemiological studies strongly suggested that poor lifestyle habits, such as an unhealthy diet, obesity, and lack of exercise, are some major risk factors that can contribute to the early onset of high blood pressure.

Some researchers also found that excessive energy intake and obesity are major causes of hypertension. Dr. Savica V, the lead author in the study "The effect of nutrition on blood pressure" wrote, "Obesity is associated with increased activity of the renin-angiotensin-aldosterone and sympathetic nervous systems, possibly other mineralocorticoid activity, insulin resistance, salt-sensitive hypertension, and excess salt intake, and reduced kidney function".

High sodium chloride intake strongly predisposes to hypertension".

"Increased alcohol consumption may acutely elevate blood pressure. High intakes of potassium, polyunsaturated fatty acids, and protein, along with exercise and possibly vitamin D, may reduce blood pressure".

In the review of all the causative risk factors, you may find that the only natural way to prevent and treat hypertension is to follow a diet with a high intake of fruits and vegetables and whole grains and less in saturated and trans fat, red meat and processed food accompanied with a healthy lifestyle and moderate exercise.

Conventional hypertensive medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.

If you currently taking hypertensive medicine, please make sure you know all the side effects of the preventive measure.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae, and is native to the tropics of the Americas, and was first cultivated in Mexico several centuries

Malaysian plants pucuk ubi (Manihot esculenta), pucuk betik (Carica papaya), Ulam Raja (Cosmos caudatus), pegaga (Centella asiatica) and kacang botol (Psophocarpus tetragonolobus) was selected to the examine their effects on key enzymes related to type 2 diabetes and hypertension.

The hexane extract of pucuk ubi (95.01%) and dichloromethane extract of kacang botol (38.94%) showed the highest inhibitory potential against alpha-glucosidase in the alpha-glucosidase inhibition assay.

Furthermore, in the iACE inhibition assay, the inhibitory potential was highest in the hexane extract of pegaga (48.45%) and dichloromethane extract of pucuk betik (59.77%).

These results suggested that papaya may have a nutraceutical potential for hyperglycemia and hypertension prevention associated with type 2 diabetes.

Male albino Wistar rats randomly were divided into three batches (15 rats per batch)-renal, DOCA-salt hypertensives, and normotensives in the study to examine the antihypertensive effect of crude ethanol extract from the unripened fruit of Carica papaya.

Each batch was further divided into three groups-the untreated, hydralazine, and extract-treated groups.


Before injection of crude ethanol extract, the basal (control) mean arterial blood pressure (MAP) was 93.8 +/- 4.5, 175.2 +/- 5. 1 and 181.3 +/- 6.2 mmHg in the normotensive, renal, and DOCA-salt hypertensives, respectively.
Groups treated with extract produced about 28% more depression of MAP than hydralazine in the hypertensive groups treated with hydralazine (200 microg/100 g i. v) and extract (20 mg/kg.i.v).

In vitro, using isolated rabbit arterial (aorta, renal and vertebral) strips showed that the papaya extract (10 microg/mL) produced relaxation of vascular muscle tone.

According to the findings, the fruit juice of C. papaya probably processes antihypertensive agent(s) which exhibits mainly alpha-adrenoceptor activity.

Taken together, the unripe fruit of papaya may have a significant effect in reducing the risk of hypertension and treatment of hypertension with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco, and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(1) In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension by Loh SP1, Hadira O.(PubMed)
(2) Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat by Eno AE1, Owo OI, Itam EH, Konya RS. (PubMed)
(3) The effect of nutrition on blood pressure by Savica V1, Bellinghieri G, Kopple JD(PubMed)

#Cucumber's Water/Ethanol #Extract and #Cucurbitacin B (CuB) Inhibit Pro-InflammatoryCytokines Against the Onset of Cardiovascular Disease (CVD)

Kyle J. Norton

Cardiovascular disease (CVD) is a class of diseases associated with blockage of blood vessels that heart disease and stroke, depending on the affected location.

Most cases of CVD are caused by reduced oxygen-rich blood inducing heart damage or the death of neurons in the brain.

In other words, if the reduced oxygen-rich blood flow occurs in the heart, it causes heart disease. On the other hand, if the reduced rich oxygen blood occurs in the brain, it causes a stroke.

Most cases of CVD in the Western world are coronary heart disease involved in plaque accumulated on the arterial wall due to an unhealthy diet with high saturated and trans fat and a lifestyle such as smoking accompanied by an overdose of the supplement of calcium.

According to US statistics, from 2006 to 2016, the US death rate from CVD decreased by 18.6% and from coronary heart disease by 31.8%.

Believe it or not, CVD has caused a significant burden in the US healthcare system with the annual total cost at $351.2 billion in 2014-2015, with $213.8 billion in direct cost, including 46% for inpatient care.

Some researchers suggested that the increase of CVD, particularly in coronary heart disease at the alarming rate in the US, is probably associated with the promotion of a high-fat diet over the past few decades, accompanied by a sedentary lifestyle.

Dr. Jane E Freedman wrote, "Over the past two decades, significant progress has been made in the treatment of acute and chronic cardiovascular disease".

And, "According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease".

Additionally, "Dietary intake of specific nutrients has been suggested as a means of modifying the progression of cardiovascular disease. One such example is the proposed use of foods rich in select vitamins or flavonoids. Epidemiologic studies have reported an inverse relationship between the total dietary intake of plant flavonoids and the incidence of cardiovascular disease".

In other words, if you follow a high-fat diet, you are at substantial risk of diseases associated with obesity, including CVD.

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

In finding a natural compound that has a potential effect on endothelium in the onset of cardiovascular diseases(CVD), researchers examined the water/ethanol extract of Cucumis sativus L. (CSE) fruit anti-CVD activity.

The study included water/ethanol extract of Cucumis sativus L. (CSE) fruit effect in the attenuation of the damaging effect of pro-inflammatory lipopolysaccharide (LPS) in vitro model of endothelial cells associated with the onset of CVD.

According to the tested assay, the administration of CSE reduced LPS-induced cytotoxicity and decreased cellular detachment, restoring the expression of tight junction ZO-1 in the contribution to barrier function.

In protein analysis, Cucumis sativus L. inhibited the early secretion of inflammatory IL-8 and Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inflammatory cytokines IL-6 and IL-1α occurred late at 7 and 24 h respectively.

Additionally, in the prevention of the overexpression of pro-inflammatory cytokines, CSE stimulated the secretion of anti-inflammatory IL-10 and increased the production of IL-18 and IFN-γ in the modulation of the immune response.

Furthermore, according to the tested doses differentiation, the angiogenetic activity induced by inflammatory LPS was also prevented by the injection of Cucumis sativus L. extract.

Dr. wrote, at the end of the experiment, " Our results have clearly demonstrated that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells (associated with the risk of CVD)".

Moreover, also in vivo, extracted the compounds of Cucumis melo L. protected the impairment of the endothelial barrier associated with the risk of CVD induced by intraperitoneal injection of a high dose of CuEC (2 mg/kg).

In other words, cucurbitacins at a higher dose can induce toxicity to the cells of the endothelium, however, at low doses, CuEC (1 mg/kg) can lead to a decline in systolic blood pressure (SBP) without causing toxicity in mice by suppressing the angiotensin II (Ang II)-induced SBP increase.

Interestingly, the efficacy of CuEC's antihypertensive property was involved in facilitating acetylcholine-mediated vasodilation in the mesenteric arteries of tested mice.

Researchers after taking into account co and con-founders said, " In vitro studies showed that CuEC induced vasodilation in a dose-dependent manner in mesenteric arteries of both mice and rats. Pretreatment with CuEC inhibited phenylephrine-mediated vasoconstriction".

Taken together, cucumber and its bioactive compound cucurbitacin B (CuB) at the lower dose may be used for the treatment of cardiovascular diseases, pending the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells by Bernardini C1, Zannoni A2, Bertocchi M2, Tubon I2, Fernandez M2, Forni M. (PubMed)
(2) Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao & Hu Xu. (Hypertensive Research)
(3) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (Journal of the American College of Cardiology)

#Broccoli' Sulforaphane (SF) Enhances Genes Associated with Xenobiotic Metabolism Against the Risk of #Cancer, According to Studies

Kyle J. Norton

Xenobiotic metabolism is an action that protects the host against chemicals that affect normal metabolism.
Other common metabolisms may include
* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides and also has been found to protect the gut mucosal barrier in preserving the ability to absorb nutrients.

* Drug metabolism is the process to alter chemicals of a drug that may cause harm to the body

The gut microbiota plays a critical role in regulating the systemic metabolism of the host including producing vitamins, synthesizing all essential and nonessential amino acids, and carrying out biotransformation of bile by interacting with other organs such as the intestine, liver, brain, and other organs through the host-microbiota and co-metabolism structure to form an ametabolic axis.

More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of dietary nutrients in the digestive system

* Gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.

* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestine in nutrient adsorption.

* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

The imbalance of the ratio of gut microbiota may have a negative impact on human health and diseases.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color, and the mass of flower heads surrounded by leaves evolved from a wild cabbage plant on the continent of Europe.

In finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF), the isothiocyanate derived from 4-methyl-sulphinyl butyl glucosinolate in broccoli induce-xenobiotic metabolizing.

The study included 16 subjects randomized, into a 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.

According to the results of the trial, consumption of high glucosinolate broccoli showed a strong effect in the improvement of several xenobiotics metabolizing genes, including thioredoxin reductase, Aldo-keto reductases, and glutamate-cysteine ligase modifier subunit.

Furthermore, the affected genes also have been found to be improved after exposure to SF, in cell and animal models.

Compared to phytochemical sulforaphane (SF) and sulforaphane (SF), only 1 such gene was affected in the consumption of standard broccoli.

Taken together, the consequences of these results suggest that the broccoli processes the potential anticarcinogenic activity by upregulating the gene associated with xenobiotic metabolism, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Consuming broccoli does not induce genes associated with xenobioticmetabolism and cell cycle control in human gastric mucosa by Gasper AV1, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barrett DA, Mithen RF. (PubMed)

#Healthyfood #Broccoli's #Sulforaphane (SFN) Inhibits Parameters Associated with the Onset of #DiabeticCardiomyopathy in #Diabetes

Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.

Cardiomyopathy is a disease associated with the heart muscle, leading to reduce functions of the heart to pump blood to the rest of the body.

Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased accumulation of fluid in the lungs.

Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, and heart rate.

* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of diabetic complications, researchers examined the effect of sulforaphane (SFN) on T2DM-induced cardiac lipid accumulation and subsequent cardiomyopathy.

The study included male C57BL/6J mice fed a high-fat diet for 3months to induce insulin resistance, followed by treatment with 100mg/kg body-weight streptozotocin to induce hyperglycemia as the T2DM mouse model compared to age-matched mice fed a normal diet as control.

According to the tested analysis,
* SFN treatment significantly attenuated cardiac remodeling and dysfunction induced by T2DM.

* SFN treatment also significantly inhibited cardiac lipid accumulation, measured by Oil Red O staining, and improved cardiac inflammation oxidative stress and fibrosis, shown by down-regulating diabetes-induced PAI-1, TNF-α, CTGF, TGF-β, 3-NT, and 4-HNE expression involved in oxidation.

* SFN upregulated the expression of the gene associated with the promotion of antioxidant enzymes and decreased the expression in enhancing the initiation of oxidative stress.

* SFN also reversed diabetes-induced inhibition of LKB1/AMPK and its downstream targets associated with the regulation of lipid, cholesterol, and glucose metabolism.

Based on the results, researchers wrote, " SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2DM-induced lipotoxicity and cardiomyopathy".

Taken together, broccoli processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of the LKB1/AMPK pathway by Zhang Z1, Wang S1, Zhou S1, Yan X2, Wang Y1, Chen J3, Mellen N3, Kong M4, Gu J5, Tan Y2, Zheng Y6, Cai L. (PubMed)

The Effects of #Herbal #Eyebright Single Dose #EyeDrops on #CatarrhalConjunctivitis, According to Studies

Kyle J. Norton

The eyes are a complex optical system that allows us to see by reacting to light.
There are many factors that can cause eye problems that disturb vision including
* Severe, sudden eye pain
* Recurrent pain in or around the eye
* Persistent eye itching, burning, or a heavy discharge in the eyes
* Sudden change in vision
* Unusual, even painful, sensitivity to light or glare
* Swollen, and red eyes

Eye diseases may induce symptoms of hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots, seeing rainbows or halos around lights, and severe onset of floaters.

Most cases of eye inflammation are caused by an infection by viruses or bacteria,

Treatment of eye inflammation is totally depending on which parts of the eye are affected. The condition has been found to progress to a severe form if untreated.

Uveitis is a form of eye inflammation that affects the middle layer of tissue in the eye wall (uvea), inducing symptoms of eye redness, pain, and blurred vision. The condition can affect one or both eyes

Pink eye or conjunctivitis is the inflammation or infection of the transparent membrane that lines your eyelid and eyeball

Conjunctivitis is most caused by commonly caused by a bacterial or viral infection, an allergic reaction, particularly in babies with an incompletely opened tear duct.

The most common symptoms of conjunctivitis are redness in one or both eyes, itchiness in one or both eyes, a gritty feeling in one or both eyes, a discharge in one or both eyes and tearing

On finding a natural ingredient for the prevention and treatment of eye diseases, scientists examined the efficacy of eye drops made from Euphrasia rostkoviana Hayne on patients with catarrhal conjunctivitis.

Eyebright is one of the species of flowering plants, genus Euphrasia, belonging to the family Orobanchaceae, native to Europe.

The plant has been used in traditional and herbal medicine to treat eye infections and to relieve inflammation caused by colds, coughs, sinus infections, sore throats, and hay fever.

The prospective, open-label, one-armed, multicentered, multinational cohort trial conducted by the Witwatersrand University included 12 experienced anthroposophical general practitioners and ophthalmologists in Germany and Switzerland and patients who were treated with one drop of Euphrasia single-dose eye drops 1-5 times a day.

According to the differentiation of all symptoms that were given for the right or left eye separately, the eye drop showed a complete recovery in 53 patients (81.5%) and a clear improvement in 11 patients (17.0%).

However, there was a slight worsening in 1 patient which could only be determined in the second week of treatment (1.5%).

No serious adverse events were observed during the entire trial.

The efficacy and tolerability were evaluated by the patients and doctors as "good" to "very good" in more than 85%.

Based on the results, researchers suggest, "Euphrasia single-dose eye drops can effectively and safely be used for various conjunctival conditions by general practitioners and ophthalmologists. A dosage of one drop three times a day seems to be the generally prescribed dosage".

Taken together, Eyebright may be considered a remedy for the treatment of catarrhal conjunctivitis, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Prospective cohort trial of Euphrasia single-dose eye drops in conjunctivitis by Stoss M1, Michels C, Peter E, Beutke R, Gorter RW. (PubMed)